NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2766762818|ref|WP_363777117|]
View 

ATP-binding protein, partial [Sphaerisporangium sp. NPDC051017]

Protein Classification

ATP-binding protein( domain architecture ID 10494905)

ATP-binding protein with a histidine kinase-like ATPase domain

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 250-353 1.28e-10

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


:

Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 58.15  E-value: 1.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2766762818 250 AVAELLDNAARHSQPNTSVEVSIRAMHNGAVIVIDDgGVGMHDQETRQATVLLSGEKAVDVTKLGdppkFGFPVVGLLAK 329
Cdd:pfam02518   9 VLSNLLDNALKHAAKAGEITVTLSEGGELTLTVEDN-GIGIPPEDLPRIFEPFSTADKRGGGGTG----LGLSIVRKLVE 83

                          90       100
                  ....*....|....*....|....
gi 2766762818 330 RYGFHASVDSaSPYGGVRAVVFLP 353
Cdd:pfam02518  84 LLGGTITVES-EPGGGTTVTLTLP 106
 
Name Accession Description Interval E-value
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 250-353 1.28e-10

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 58.15  E-value: 1.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2766762818 250 AVAELLDNAARHSQPNTSVEVSIRAMHNGAVIVIDDgGVGMHDQETRQATVLLSGEKAVDVTKLGdppkFGFPVVGLLAK 329
Cdd:pfam02518   9 VLSNLLDNALKHAAKAGEITVTLSEGGELTLTVEDN-GIGIPPEDLPRIFEPFSTADKRGGGGTG----LGLSIVRKLVE 83

                          90       100
                  ....*....|....*....|....
gi 2766762818 330 RYGFHASVDSaSPYGGVRAVVFLP 353
Cdd:pfam02518  84 LLGGTITVES-EPGGGTTVTLTLP 106
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
206-355 3.03e-09

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 57.22  E-value: 3.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2766762818 206 QRAACPVEDVVRGATSRIRDY---RRVRVHAQIDTAVVGRVVEPVVL--AVAELLDNAARHSQPNTSVEVSIRAMHNGAV 280
Cdd:COG2205    87 ELEPVDLAELLEEAVEELRPLaeeKGIRLELDLPPELPLVYADPELLeqVLANLLDNAIKYSPPGGTITISARREGDGVR 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2766762818 281 IVIDDGGVGMHDQEtrQATVLlsgEKAVDVTKLGDPPKFGfpvVGL-----LAKRYGFHASVDSaSPYGGVRAVVFLPNA 355
Cdd:COG2205   167 ISVSDNGPGIPEEE--LERIF---ERFYRGDNSRGEGGTG---LGLaivkrIVEAHGGTIWVES-EPGGGTTFTVTLPLA 237
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 250-353 4.33e-09

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 53.81  E-value: 4.33e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2766762818  250 AVAELLDNAARHSQPNTSVEVSIRAMHNGAVIVIDDGGVGMHDQEtrQATVLLSGEKAVDVTKLGDPPKFGFPVVGLLAK 329
Cdd:smart00387   9 VLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPED--LEKIFEPFFRTDKRSRKIGGTGLGLSIVKKLVE 86

                           90       100
                   ....*....|....*....|....
gi 2766762818  330 RYGFHASVDSaSPYGGVRAVVFLP 353
Cdd:smart00387  87 LHGGEISVES-EPGGGTTFTITLP 109
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 249-352 1.71e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 38.16  E-value: 1.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2766762818 249 LAVAELLDNAARHSQPNTSVEVSIRAmHNGAVIVIDDGGVGMHDQEtrQATVLlsgekavdvTKLGDPPK-------FGF 321
Cdd:cd16940    16 LLLRNLVDNAVRYSPQGSRVEIKLSA-DDGAVIRVEDNGPGIDEEE--LEALF---------ERFYRSDGqnyggsgLGL 83

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2766762818 322 PVVGLLAKRYGFHASVDSAsPYGGVRAVVFL 352
Cdd:cd16940    84 SIVKRIVELHGGQIFLGNA-QGGGLEAWVRL 113
 
Name Accession Description Interval E-value
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 250-353 1.28e-10

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 58.15  E-value: 1.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2766762818 250 AVAELLDNAARHSQPNTSVEVSIRAMHNGAVIVIDDgGVGMHDQETRQATVLLSGEKAVDVTKLGdppkFGFPVVGLLAK 329
Cdd:pfam02518   9 VLSNLLDNALKHAAKAGEITVTLSEGGELTLTVEDN-GIGIPPEDLPRIFEPFSTADKRGGGGTG----LGLSIVRKLVE 83

                          90       100
                  ....*....|....*....|....
gi 2766762818 330 RYGFHASVDSaSPYGGVRAVVFLP 353
Cdd:pfam02518  84 LLGGTITVES-EPGGGTTVTLTLP 106
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
206-355 3.03e-09

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 57.22  E-value: 3.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2766762818 206 QRAACPVEDVVRGATSRIRDY---RRVRVHAQIDTAVVGRVVEPVVL--AVAELLDNAARHSQPNTSVEVSIRAMHNGAV 280
Cdd:COG2205    87 ELEPVDLAELLEEAVEELRPLaeeKGIRLELDLPPELPLVYADPELLeqVLANLLDNAIKYSPPGGTITISARREGDGVR 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2766762818 281 IVIDDGGVGMHDQEtrQATVLlsgEKAVDVTKLGDPPKFGfpvVGL-----LAKRYGFHASVDSaSPYGGVRAVVFLPNA 355
Cdd:COG2205   167 ISVSDNGPGIPEEE--LERIF---ERFYRGDNSRGEGGTG---LGLaivkrIVEAHGGTIWVES-EPGGGTTFTVTLPLA 237
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 250-353 4.33e-09

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 53.81  E-value: 4.33e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2766762818  250 AVAELLDNAARHSQPNTSVEVSIRAMHNGAVIVIDDGGVGMHDQEtrQATVLLSGEKAVDVTKLGDPPKFGFPVVGLLAK 329
Cdd:smart00387   9 VLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPED--LEKIFEPFFRTDKRSRKIGGTGLGLSIVKKLVE 86

                           90       100
                   ....*....|....*....|....
gi 2766762818  330 RYGFHASVDSaSPYGGVRAVVFLP 353
Cdd:smart00387  87 LHGGEISVES-EPGGGTTFTITLP 109
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
212-355 1.80e-05

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 46.44  E-value: 1.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2766762818 212 VEDVVRGATSRIRDyRRVRVHAQIDTAVVGRVVEPVVL--AVAELLDNAARHSQPNTSVEVSIRAMHNGAVIVIDDGGVG 289
Cdd:COG0642   188 LEEVVELFRPLAEE-KGIELELDLPDDLPTVRGDPDRLrqVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPG 266

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2766762818 290 MHDQEtrQATVLLSGEKAVDVTK---LGdppkFGFPVVGLLAKRYGFHASVDSaSPYGGVRAVVFLPNA 355
Cdd:COG0642   267 IPPED--LERIFEPFFRTDPSRRgggTG----LGLAIVKRIVELHGGTIEVES-EPGKGTTFTVTLPLA 328
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
212-294 8.86e-05

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 44.54  E-value: 8.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2766762818 212 VEDVVRGATSRIRDyRRVRVHAQIDTAVVGRVVEPVVL--AVAELLDNAARHSQPNTSVEVSIRAMHNGAVIVIDDGGVG 289
Cdd:COG5002   246 LEEVVEELRPLAEE-KGIELELDLPEDPLLVLGDPDRLeqVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIG 324


                  ....*
gi 2766762818 290 MHDQE 294
Cdd:COG5002   325 IPEED 329
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 249-352 1.71e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 38.16  E-value: 1.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2766762818 249 LAVAELLDNAARHSQPNTSVEVSIRAmHNGAVIVIDDGGVGMHDQEtrQATVLlsgekavdvTKLGDPPK-------FGF 321
Cdd:cd16940    16 LLLRNLVDNAVRYSPQGSRVEIKLSA-DDGAVIRVEDNGPGIDEEE--LEALF---------ERFYRSDGqnyggsgLGL 83

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2766762818 322 PVVGLLAKRYGFHASVDSAsPYGGVRAVVFL 352
Cdd:cd16940    84 SIVKRIVELHGGQIFLGNA-QGGGLEAWVRL 113
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
249-290 1.81e-03

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 38.36  E-value: 1.81e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2766762818 249 LAVAELLDNAARHS---QPNTSVEVSIRAMHNGAVIVIDDGGVGM 290
Cdd:COG2172    37 LAVSEAVTNAVRHAyggDPDGPVEVELELDPDGLEIEVRDEGPGF 81
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 227-353 5.00e-03

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 39.06  E-value: 5.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2766762818 227 RRVRVHAQIDTAVVGRVVEPVVLA--VAELLDNAARHSQ----PNTSVEVSIRAMHNGAVIVIDDGGVGMHDQEtrQATV 300
Cdd:COG3290   260 RGIDLTIDIDSDLPDLPLSDTDLVtiLGNLLDNAIEAVEklpeEERRVELSIRDDGDELVIEVEDSGPGIPEEL--LEKI 337

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2766762818 301 LLSGEKavdvTKLGDPPKFGFPVVGLLAKRYGFHASVDSaSPYGGVRAVVFLP 353
Cdd:COG3290   338 FERGFS----TKLGEGRGLGLALVKQIVEKYGGTIEVES-EEGEGTVFTVRLP 385
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 254-352 6.76e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 36.84  E-value: 6.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2766762818 254 LLDNAARHSqpNTSVEVSIRAMHNGAVIVIDDGGVGMHDQEtRQAtVLLSGEKAvDVTKLGDppKFGFPVVGLLAKRYGF 333
Cdd:cd16954    45 LLDNACKWC--LEFVEVTARQTDGGLHLIVDDDGPGVPESQ-RSK-IFQRGQRL-DEQRPGQ--GLGLAIAKEIVEQYGG 117

                          90
                  ....*....|....*....
gi 2766762818 334 HASVDSaSPYGGVRAVVFL 352
Cdd:cd16954   118 ELSLSD-SPLGGARFEVVF 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH