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Conserved domains on  [gi|2768337613|ref|WP_365305606|]
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SMI1/KNR4 family protein [Streptomyces sp. NPDC051642]

Protein Classification

SMI1/KNR4 family protein( domain architecture ID 10627618)

SMI1/KNR4 family protein may be involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation

CATH:  3.40.1580.10
Gene Ontology:  GO:0042546
PubMed:  8289782
SCOP:  4002285

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WHH pfam14414
A nuclease of the HNH/ENDO VII superfamily with conserved WHH; WHH is a predicted nuclease of ...
 96-135 1.02e-11

A nuclease of the HNH/ENDO VII superfamily with conserved WHH; WHH is a predicted nuclease of the HNH/ENDO VII superfamily of the treble clef fold. The name is derived from the conserved motif WHH. It is found in bacterial polymorphic toxin systems and functions as a toxin module. WHH is the shortest version of HNH nuclease families. Like AHH and LHH, the WHH nuclease contains 4 conserved histidines of which the first one is predicted to bind a metal-ion and other three ones are involved in activation of water molecule for hydrolysis.


:

Pssm-ID: 433943  Cd Length: 43  Bit Score: 58.94  E-value: 1.02e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2768337613  96 ATPHGWTWHHVVGTRRLALVPVDVKALLRHHGGIATAAVD 135
Cdd:pfam14414   4 ATPKGYTWHHLDDTGTMQLVPEELHNATPHTGGVSLWKKG 43
SMI1_KNR4 pfam09346
SMI1 / KNR4 family (SUKH-1); Proteins in this family are involved in the regulation of 1, ...
 161-298 4.18e-09

SMI1 / KNR4 family (SUKH-1); Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation. Genome contextual information showed that SMI1 are primary immunity proteins in bacterial toxin systems.


:

Pssm-ID: 430545  Cd Length: 120  Bit Score: 53.98  E-value: 4.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2768337613 161 VTEAQVQGVEEDLGYRLPGAYRSFLKAAGGsapiGTALDAELGLLidqPFFTVRDE-AAVNDLVYINKCLRDHLTKDYLA 239
Cdd:pfam09346   2 ATEEEIQEFEKELGVKLPEDYREFLLKTNG----GGGLFEGLDLL---PLEEIEEEyEDLLAEDSLYFIREWGLPEGLIP 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2768337613 240 VGFVQGG-LLAVKVK-GQAIGSVWFCayddardldpsqapaDRVERLLLPAGDDFDQFLAR 298
Cdd:pfam09346  75 FADDGGGdYLCLDLRdGGEEGQVYFW---------------DEDDDELKLVADSFEEFLER 120
 
Name Accession Description Interval E-value
WHH pfam14414
A nuclease of the HNH/ENDO VII superfamily with conserved WHH; WHH is a predicted nuclease of ...
 96-135 1.02e-11

A nuclease of the HNH/ENDO VII superfamily with conserved WHH; WHH is a predicted nuclease of the HNH/ENDO VII superfamily of the treble clef fold. The name is derived from the conserved motif WHH. It is found in bacterial polymorphic toxin systems and functions as a toxin module. WHH is the shortest version of HNH nuclease families. Like AHH and LHH, the WHH nuclease contains 4 conserved histidines of which the first one is predicted to bind a metal-ion and other three ones are involved in activation of water molecule for hydrolysis.


Pssm-ID: 433943  Cd Length: 43  Bit Score: 58.94  E-value: 1.02e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2768337613  96 ATPHGWTWHHVVGTRRLALVPVDVKALLRHHGGIATAAVD 135
Cdd:pfam14414   4 ATPKGYTWHHLDDTGTMQLVPEELHNATPHTGGVSLWKKG 43
SMI1_KNR4 pfam09346
SMI1 / KNR4 family (SUKH-1); Proteins in this family are involved in the regulation of 1, ...
 161-298 4.18e-09

SMI1 / KNR4 family (SUKH-1); Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation. Genome contextual information showed that SMI1 are primary immunity proteins in bacterial toxin systems.


Pssm-ID: 430545  Cd Length: 120  Bit Score: 53.98  E-value: 4.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2768337613 161 VTEAQVQGVEEDLGYRLPGAYRSFLKAAGGsapiGTALDAELGLLidqPFFTVRDE-AAVNDLVYINKCLRDHLTKDYLA 239
Cdd:pfam09346   2 ATEEEIQEFEKELGVKLPEDYREFLLKTNG----GGGLFEGLDLL---PLEEIEEEyEDLLAEDSLYFIREWGLPEGLIP 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2768337613 240 VGFVQGG-LLAVKVK-GQAIGSVWFCayddardldpsqapaDRVERLLLPAGDDFDQFLAR 298
Cdd:pfam09346  75 FADDGGGdYLCLDLRdGGEEGQVYFW---------------DEDDDELKLVADSFEEFLER 120
SMI1_KNR4 smart00860
SMI1 / KNR4 family; Proteins in this family are involved in the regulation of 1,3-beta-glucan ...
 161-296 7.97e-07

SMI1 / KNR4 family; Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation.


Pssm-ID: 214864  Cd Length: 127  Bit Score: 47.64  E-value: 7.97e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2768337613  161 VTEAQVQGVEEDLGYRLPGAYRSFLKAAGGSAPIGTALDAELGLLIDQPFFTVRDEAAVNDLVYINKCLRDHLTKDYLAV 240
Cdd:smart00860   2 ATEEEIAELEKKLGIKLPEDYKEFLLLYNGGELGGSAELPLGGLSLLDLLELEAAIEDQEEIDSDIEEEEYALPGWLIFI 81

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2768337613  241 GFVQGGLLAV-KVKGQAIGSVWFCAYDDARDLDPSQAPAdrverlllpagDDFDQFL 296
Cdd:smart00860  82 ADGGGGGILIdLDDGPGGEGGEVGVILFGDDDDEKYVVA-----------DSFEEFL 127
 
Name Accession Description Interval E-value
WHH pfam14414
A nuclease of the HNH/ENDO VII superfamily with conserved WHH; WHH is a predicted nuclease of ...
 96-135 1.02e-11

A nuclease of the HNH/ENDO VII superfamily with conserved WHH; WHH is a predicted nuclease of the HNH/ENDO VII superfamily of the treble clef fold. The name is derived from the conserved motif WHH. It is found in bacterial polymorphic toxin systems and functions as a toxin module. WHH is the shortest version of HNH nuclease families. Like AHH and LHH, the WHH nuclease contains 4 conserved histidines of which the first one is predicted to bind a metal-ion and other three ones are involved in activation of water molecule for hydrolysis.


Pssm-ID: 433943  Cd Length: 43  Bit Score: 58.94  E-value: 1.02e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2768337613  96 ATPHGWTWHHVVGTRRLALVPVDVKALLRHHGGIATAAVD 135
Cdd:pfam14414   4 ATPKGYTWHHLDDTGTMQLVPEELHNATPHTGGVSLWKKG 43
Colicin-DNase pfam12639
DNase/tRNase domain of colicin-like bacteriocin; Colicin-like bacteriocins are complex ...
 37-127 2.33e-09

DNase/tRNase domain of colicin-like bacteriocin; Colicin-like bacteriocins are complex structures with an N-terminal beta-barrel translocation domain (pfam09000), a long double-alpha-helical receptor-binding domain (pfam11570) and this C-terminal RNAse/DNase domain with endonuclease activity. Their competitor bacteriocidal action is by a process that involves binding to a surface receptor, entering the cell, and, finally, killing it. The lethal action of colicin E3 is a specific cleavage in the ribosomal decoding A site. The crystal structure of colicin E3 reveals a Y-shaped molecule with the receptor binding domain forming a 100 Angstrom long stalk and the two globular heads of the translocation domain and this catalytic domain comprising the two arms.


Pssm-ID: 432688  Cd Length: 96  Bit Score: 54.01  E-value: 2.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2768337613  37 VRMDEHGYPDFSPYARAVAEIAEPpegFGVDEL-------RLTDYVSANAALAA--TGHELwDTVPAVATPHGWTWHHVV 107
Cdd:pfam12639   1 VGFDKEGFPDFSSVAKVQLPIELM---KASRDVqfkiankALKEEVANDPELANqfTKEQL-EGIENGKTPEGYTWHHHQ 76

                          90       100
                  ....*....|....*....|
gi 2768337613 108 GTRRLALVPVDVKALLRHHG 127
Cdd:pfam12639  77 DTGTMQLVPTEIHDKTGHTG 96
SMI1_KNR4 pfam09346
SMI1 / KNR4 family (SUKH-1); Proteins in this family are involved in the regulation of 1, ...
 161-298 4.18e-09

SMI1 / KNR4 family (SUKH-1); Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation. Genome contextual information showed that SMI1 are primary immunity proteins in bacterial toxin systems.


Pssm-ID: 430545  Cd Length: 120  Bit Score: 53.98  E-value: 4.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2768337613 161 VTEAQVQGVEEDLGYRLPGAYRSFLKAAGGsapiGTALDAELGLLidqPFFTVRDE-AAVNDLVYINKCLRDHLTKDYLA 239
Cdd:pfam09346   2 ATEEEIQEFEKELGVKLPEDYREFLLKTNG----GGGLFEGLDLL---PLEEIEEEyEDLLAEDSLYFIREWGLPEGLIP 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2768337613 240 VGFVQGG-LLAVKVK-GQAIGSVWFCayddardldpsqapaDRVERLLLPAGDDFDQFLAR 298
Cdd:pfam09346  75 FADDGGGdYLCLDLRdGGEEGQVYFW---------------DEDDDELKLVADSFEEFLER 120
SMI1_KNR4 smart00860
SMI1 / KNR4 family; Proteins in this family are involved in the regulation of 1,3-beta-glucan ...
 161-296 7.97e-07

SMI1 / KNR4 family; Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation.


Pssm-ID: 214864  Cd Length: 127  Bit Score: 47.64  E-value: 7.97e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2768337613  161 VTEAQVQGVEEDLGYRLPGAYRSFLKAAGGSAPIGTALDAELGLLIDQPFFTVRDEAAVNDLVYINKCLRDHLTKDYLAV 240
Cdd:smart00860   2 ATEEEIAELEKKLGIKLPEDYKEFLLLYNGGELGGSAELPLGGLSLLDLLELEAAIEDQEEIDSDIEEEEYALPGWLIFI 81

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2768337613  241 GFVQGGLLAV-KVKGQAIGSVWFCAYDDARDLDPSQAPAdrverlllpagDDFDQFL 296
Cdd:smart00860  82 ADGGGGGILIdLDDGPGGEGGEVGVILFGDDDDEKYVVA-----------DSFEEFL 127
SUKH_6 pfam14568
SMI1-KNR4 cell-wall; Members of this family are related to the SMI1/KNR4-like or SUKH ...
 163-267 4.49e-04

SMI1-KNR4 cell-wall; Members of this family are related to the SMI1/KNR4-like or SUKH superfamily of proteins.


Pssm-ID: 434043  Cd Length: 120  Bit Score: 39.28  E-value: 4.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2768337613 163 EAQVQGVEEDLGYRLPGAYRSFLKAAGGSAPIGTALDAELGLLI-DQPFFTVRDEAAVNDLVYINKClrDHLTKDYLAVG 241
Cdd:pfam14568   1 EEEIAEAEKKLGVKLPEDYKEFLKKYNGGYFGGNEFYGISEDSIvNDALANLLLEGILEDKELYIDE--DGLPEGLLPIA 78

                          90       100
                  ....*....|....*....|....*..
gi 2768337613 242 FVQGG-LLAVKVKGQAIGSVWFCAYDD 267
Cdd:pfam14568  79 DDGGGdYFCFDYGENGEPKVVFWDSEE 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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