|
Name |
Accession |
Description |
Interval |
E-value |
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
119-441 |
7.68e-55 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 185.50 E-value: 7.68e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 119 YLALSARLYGGRLTIARSRAEIEALQPVFLNILWISLLPTVLIALSGGLILARRSQRHVEVIRAALERITGGNLGARVVT 198
Cdd:COG0642 2 LLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 199 GKRWSDDLVRIGGAVNTMADAQERSVTALRQVSSDIAHDLKTPVQRVSLQLEALQEVVKETQAsELVAQTRAEVEGIASV 278
Cdd:COG0642 82 LLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQR-EYLETILRSADRLLRL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 279 FQSLLQLAQVENGALQAAFAPVDLAQLCLTMVDVYEPSAQNAGQTISCDVAPDV-QVMGEKNLLGQMIANLLENALRHSG 357
Cdd:COG0642 161 INDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLpTVRGDPDRLRQVLLNLLSNAIKYTP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 358 TGSKISLSLVCRAGTAELTVADTGPGIPEEERARVVQRLYRLDRSRNTPGNGLGLSLVDGVARLHGARLNFGDA-NPGLR 436
Cdd:COG0642 241 EGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGGTGLGLAIVKRIVELHGGTIEVESEpGKGTT 320
|
....*
gi 2769203217 437 VCVSF 441
Cdd:COG0642 321 FTVTL 325
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
103-426 |
5.55e-54 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 184.76 E-value: 5.55e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 103 FHIISLEEGRATLNGEYLALSARLYGGRLTIARSRAEIEALQPVFLNILWISLLPTVLIALSGGLILARRSQRHVE-VIR 181
Cdd:COG5002 33 LLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLaLLI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 182 AALERITGGNLGARVVTGKRWSDDLVRIGGAVNTMADAQERSVTALRQVS-------SDIAHDLKTPVQRVSLQLEALQE 254
Cdd:COG5002 113 LLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEqmrrefvANVSHELRTPLTSIRGYLELLLD 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 255 VVKET--QASELVAQTRAEVEGIASVFQSLLQLAQVENGALQAAFAPVDLAQLCLTMVDVYEPSAQNAGQTISCDVAPD- 331
Cdd:COG5002 193 GAADDpeERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDp 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 332 VQVMGEKNLLGQMIANLLENALRHSGTGSKISLSLVCRAGTAELTVADTGPGIPEEERARVVQRLYRLD--RSRNTPGNG 409
Cdd:COG5002 273 LLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDksRSRETGGTG 352
|
330
....*....|....*..
gi 2769203217 410 LGLSLVDGVARLHGARL 426
Cdd:COG5002 353 LGLAIVKHIVEAHGGRI 369
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
212-441 |
9.83e-51 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 171.63 E-value: 9.83e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 212 AVNTMADAQERSVTALRQVSSDIAHDLKTPVQRVSLQLEALQEVVKETQA--SELVAQTRAEVEGIASVFQSLLQLAQVE 289
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEerRELLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 290 NGALQAAFAPVDLAQLCLTMVDVYEPSAQNAGQTISCDVAPD-VQVMGEKNLLGQMIANLLENALRHSGTGSKISLSLVC 368
Cdd:COG2205 81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPElPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARR 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2769203217 369 RAGTAELTVADTGPGIPEEERARVVQRLYRLDRSRNTPGNGLGLSLVDGVARLHGARLNFGDA-NPGLRVCVSF 441
Cdd:COG2205 161 EGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEpGGGTTFTVTL 234
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
130-426 |
5.11e-40 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 149.07 E-value: 5.11e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 130 RLTIARSR-AEIEALQPVFLNILWISLLPTVLIALSGGLIlARRSQRHVEVIRAALERITGGNLGARVvTGKRWSDDLVR 208
Cdd:TIGR01386 145 QITVALDInAHTHLLDALRKWLILIAVLLVLLTALLGWWI-TRLGLEPLRRLSAVAARISPESLDQRL-DPSRAPAELRE 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 209 IGGAVNTMADAQERSVTALRQVSSDIAHDLKTPVQRVSLQLE-ALQEVVKETQASELVAQTRAEVEGIASVFQSLLQLAQ 287
Cdd:TIGR01386 223 LAQSFNAMLGRLEDAFQRLSQFSADLAHELRTPLTNLLGQTQvALSQPRTGEEYREVLESNLEELERLSRMVSDMLFLAR 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 288 VENGALQAAFAPVDLAQLCLTMVDVYEPSAQNAGQTIscDVAPDVQVMGEKNLLGQMIANLLENALRHSGTGSKISLSLV 367
Cdd:TIGR01386 303 ADNGQLALERVRLDLAAELAKVAEYFEPLAEERGVRI--RVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIE 380
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2769203217 368 CRAGTAELTVADTGPGIPEEERARVVQRLYRLD--RSRNTPGNGLGLSLVDGVARLHGARL 426
Cdd:TIGR01386 381 RRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDpaRSNSGEGTGLGLAIVRSIMEAHGGRA 441
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
114-434 |
1.74e-34 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 134.20 E-value: 1.74e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 114 TLNGEYLALSARL-----------------YGGR----LTIARSRAeieALQPvFLN-----ILWISLLPTVLIALSGGL 167
Cdd:PRK11100 126 TLRGEYGARSTREdpadpessvmyvaapirDGGRiigvLSVGKPNS---SMAP-FIKrserrILWAGALLLGIALLIGAG 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 168 ILA------RRSQRHVEVIRAaleritggnlGARVVTGKRWSDDLVRIGGAVNTMADAQ------ERSVTALrqvssdiA 235
Cdd:PRK11100 202 VVWwlnrsiRRLTRYADAVTE----------GKPVPLPKLGSSELRELAQALESMRVKLegkayvEQYVQTL-------T 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 236 HDLKTPVQRVSLQLEALQEVVKETQASELVAQTRAEVEGIASVFQSLLQLAQVENGALQAAFAPVDLAQLCLTMVDVYEP 315
Cdd:PRK11100 265 HELKSPLAAIRGAAELLQEDPPPEDRARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEAREA 344
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 316 SAQNAGQTISCDvAPDVQVMGEKNLLGQMIANLLENALRHSGTGSKISLSLVCRAGTAELTVADTGPGIPEEERARVVQR 395
Cdd:PRK11100 345 QAAAKGITLRLR-PDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFER 423
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 2769203217 396 LYRLDRSRNTP-GNGLGLSLVDGVARLHGARLNFGDANPG 434
Cdd:PRK11100 424 FYSLPRPANGRkSTGLGLAFVREVARLHGGEVTLRNRPEG 463
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
329-441 |
1.36e-31 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 116.74 E-value: 1.36e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 329 APDVQVMGEKNLLGQMIANLLENALRHSGTGSKISLSLVCRAGtAELTVADTGPGIPEEERARVVQRLYRLDrSRNTPGN 408
Cdd:cd16940 2 AADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDG-AVIRVEDNGPGIDEEELEALFERFYRSD-GQNYGGS 79
|
90 100 110
....*....|....*....|....*....|....
gi 2769203217 409 GLGLSLVDGVARLHGARLNFGDA-NPGLRVCVSF 441
Cdd:cd16940 80 GLGLSIVKRIVELHGGQIFLGNAqGGGLEAWVRL 113
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
152-441 |
3.19e-31 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 124.75 E-value: 3.19e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 152 WISLLPTVLIALSGGLILARRSQRHVEVIRAALERITGGNLGARVVTGKRwsDDLVRIGGAVNTMADAQERSVTALRQVS 231
Cdd:PRK10549 167 WLIVALSTLLAALATFLLARGLLAPVKRLVEGTHKLAAGDFTTRVTPTSR--DELGRLAQDFNQLASTLEKNEQMRRDFM 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 232 SDIAHDLKTPVQRVSLQLEALQEVVKETQAsELVAQTRAEVEGIASVFQSLLQLAQVENGALQAAFAPVDLAQLCLTMVD 311
Cdd:PRK10549 245 ADISHELRTPLAVLRGELEAIQDGVRKFTP-ESVASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKTPVDLVPLLEVAGG 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 312 VYEPSAQNAGQTISCDVAPDVQVMGEKNLLGQMIANLLENALRHSGTGSKISLSLVCRAGTAELTVADTGPGIPEEERAR 391
Cdd:PRK10549 324 AFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQK 403
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 2769203217 392 VVQRLYRLDRSRN--TPGNGLGLSLVDGVARLHGARLNfGDANP--GLRVCVSF 441
Cdd:PRK10549 404 LFERFYRTEGSRNraSGGSGLGLAICLNIVEAHNGRII-AAHSPfgGVSITVEL 456
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
229-425 |
2.01e-29 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 118.13 E-value: 2.01e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 229 QVSSDIAHDLKTPVQRVSLQLEALQ-----EVVKETQA--SELVAQTRAEVEGIASVFQSLLQLAQVENGALQAAFAPVD 301
Cdd:PRK09303 153 RVLAMLAHDLRTPLTAASLALETLElgqidEDTELKPAliEQLQDQARRQLEEIERLITDLLEVGRTRWEALRFNPQKLD 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 302 LAQLCLTMVDVYEPSAQNAGQTISCDVAPDV-QVMGEKNLLGQMIANLLENALRHSGTGSKISLSLVCRagTA---ELTV 377
Cdd:PRK09303 233 LGSLCQEVILELEKRWLAKSLEIQTDIPSDLpSVYADQERIRQVLLNLLDNAIKYTPEGGTITLSMLHR--TTqkvQVSI 310
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 2769203217 378 ADTGPGIPEEERARVVQRLYRLDRSRNTPGNGLGLSLVDGVARLHGAR 425
Cdd:PRK09303 311 CDTGPGIPEEEQERIFEDRVRLPRDEGTEGYGIGLSVCRRIVRVHYGQ 358
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
341-441 |
1.68e-28 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 108.07 E-value: 1.68e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 341 LGQMIANLLENALRHSGTGSKISLSLVCRAGTAELTVADTGPGIPEEERARVVQRLYRLDRSRNTPGNGLGLSLVDGVAR 420
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGGGTGLGLAIVRRIVE 80
|
90 100
....*....|....*....|..
gi 2769203217 421 LHGARLNFGDANP-GLRVCVSF 441
Cdd:cd00075 81 AHGGRITVESEPGgGTTFTVTL 102
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
152-423 |
4.75e-28 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 115.09 E-value: 4.75e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 152 WISLLPTVLIALSGGL---ILARRSQRHVEVIRAALERITGGNLGARVVTGKRWSddLVRIGGAVNTMADAQERSVTALR 228
Cdd:PRK10604 136 LLDIALLALIGLSLAFpvfLWMRPHWQDMLKLEAAAQRLGDGHLAERIHFDEGSS--LERLGVAFNQMADNINALIASKK 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 229 QVSSDIAHDLKTPVQRVSLQLEALqevvKETQASELVAQTRaEVEGIASVFQSLLQLAQVENGALQAAFAPVDLAQLCLT 308
Cdd:PRK10604 214 QLIDGIAHELRTPLVRLRYRLEMS----DNLSAAESQALNR-DIGQLEALIEELLTYARLDRPQNELHLSEPDLPAWLST 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 309 MVDVYEpsAQNAGQTISCDVAPDVQVMG-EKNLLGQMIANLLENALRHSGtgSKISLSLVCRAGTAELTVADTGPGIPEE 387
Cdd:PRK10604 289 HLADIQ--AVTPEKTVRLDTPHQGDYGAlDMRLMERVLDNLLNNALRYAH--SRVRVSLLLDGNQACLIVEDDGPGIPPE 364
|
250 260 270
....*....|....*....|....*....|....*...
gi 2769203217 388 ERARVVQRLYRLDRSRN--TPGNGLGLSLVDGVARLHG 423
Cdd:PRK10604 365 ERERVFEPFVRLDPSRDraTGGCGLGLAIVHSIALAMG 402
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
228-441 |
2.86e-27 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 111.60 E-value: 2.86e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 228 RQVSSDIAHDLKTPVQRVSLQLEaLQEVVKETQASELVAQtraeVEGIASVFQSLLQLAQVENGALQAAFAPVDLAQlcl 307
Cdd:PRK10755 138 RLFTADVAHELRTPLAGIRLHLE-LLEKQHHIDVAPLIAR----LDQMMHTVEQLLQLARAGQSFSSGHYQTVKLLE--- 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 308 tmvDVYEPS-------AQNAGQTIS-CDVAPDVQVMGEKNLLGQMIANLLENALRHSGTGSKISLSLVCRAGTAELTVAD 379
Cdd:PRK10755 210 ---DVILPSqdelsemLEQRQQTLLlPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVED 286
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2769203217 380 TGPGIPEEERARVVQRLYRLDRSRNtpGNGLGLSLVDGVARLHGARLNFGDAN--PGLRVCVSF 441
Cdd:PRK10755 287 EGPGIDESKCGELSKAFVRMDSRYG--GIGLGLSIVSRITQLHHGQFFLQNRQerSGTRAWVWL 348
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
228-434 |
3.90e-27 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 112.82 E-value: 3.90e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 228 RQVSSDIAHDLKTPVQRVSLQLEALQEVVKETQASE-LVAQTRAEVEGIASVFQSLLQLAQVENGALQAAFAPVDLAQLC 306
Cdd:PRK10337 238 RRFTSDAAHELRSPLAALKVQTEVAQLSDDDPQARKkALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLL 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 307 LTMV-DVYEPsAQNAGQTISCDV-APDVQVMGEKNLLGQMIANLLENALRHSGTGSKISLSLVCRagtaELTVADTGPGI 384
Cdd:PRK10337 318 QSAVmDIYHT-AQQAGIDVRLTLnAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNAR----NFTVRDNGPGV 392
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 2769203217 385 PEEERARVVQRLYRlDRSRNTPGNGLGLSLVDGVARLHGARLNFGDANPG 434
Cdd:PRK10337 393 TPEALARIGERFYR-PPGQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEG 441
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
131-441 |
5.43e-26 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 109.28 E-value: 5.43e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 131 LTIARSRAEIEALQPVFLNILWISLLPTVLIALSGGLILARRSQRHVEVIRAALERITGgnlgaRVVTgkrwSDDLVRig 210
Cdd:COG5000 123 LGIPLEELIGKPLEELLPELDLAELLREALERGWQEEIELTRDGRRTLLVRASPLRDDG-----YVIV----FDDITE-- 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 211 gavntMADAQERSvtALRQVSSDIAHDLKTPVQRVSLQLEALQEVVKETQASELVAQTRA------EVEGIASVFQSLLQ 284
Cdd:COG5000 192 -----LLRAERLA--AWGELARRIAHEIKNPLTPIQLSAERLRRKLADKLEEDREDLERAldtiirQVDRLKRIVDEFLD 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 285 LAQVEngalQAAFAPVDLAQLCLTMVDVYEPSAQNAGQTISCDVAPDV-QVMGEKNLLGQMIANLLENALRHSGTGSKIS 363
Cdd:COG5000 265 FARLP----EPQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLpEVLADRDQLEQVLINLLKNAIEAIEEGGEIE 340
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2769203217 364 LSLVCRAGTAELTVADTGPGIPEEERARVVQRLYrldrSRNTPGNGLGLSLVDGVARLHGARLNFGDANP-GLRVCVSF 441
Cdd:COG5000 341 VSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF----TTKPKGTGLGLAIVKKIVEEHGGTIELESRPGgGTTFTIRL 415
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
336-441 |
3.02e-25 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 99.26 E-value: 3.02e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 336 GEKNLLGQMIANLLENALRHSGTGSKISLSLVCRAGTAELTVADTGPGIPEEERARVVQRLYRLD-RSRNTPGNGLGLSL 414
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDkRSRKIGGTGLGLSI 80
|
90 100
....*....|....*....|....*...
gi 2769203217 415 VDGVARLHGARLNFGDANP-GLRVCVSF 441
Cdd:smart00387 81 VKKLVELHGGEISVESEPGgGTTFTITL 108
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
22-425 |
5.69e-25 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 107.18 E-value: 5.69e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 22 TVSLLSLAASYAFTRAAFEQSIRDDLAQDLAGFRAAPSARAVAVLVQAESADTDPGRLVLSYASPSGRIYGNGAVARDDE 101
Cdd:COG4251 80 LLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLL 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 102 gfhIISLEEGRATLNGEYLALSARLYGGRLTIARSRAEIEALQPVFLNILWISLLPTVLIALSGGLILARRSQRHVEVIR 181
Cdd:COG4251 160 ---LLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLV 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 182 AALERITGGNLGARVVTGKRWSDDLVRIGGAVNTMADAQERSVTALRQVSSDIAHDLKTPVQRVSLQLEALQEVVKET-- 259
Cdd:COG4251 237 LLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERSNEELEQFAYVASHDLREPLRKISGFSQLLEEDYGDKld 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 260 -QASELVAQTRAEVEGIASVFQSLLQLAQVENGALQaaFAPVDLAQLCLTMVDVYEPSAQNAGQTISCDVAPdvQVMGEK 338
Cdd:COG4251 317 eEGREYLERIRDAAERMQALIDDLLAYSRVGRQELE--FEPVDLNELLEEVLEDLEPRIEERGAEIEVGPLP--TVRGDP 392
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 339 NLLGQMIANLLENALRHSGTGS--KISLSLVCRAGTAELTVADTGPGIPEEERARVVQRLYRLDRSRNTPGNGLGLSLVD 416
Cdd:COG4251 393 TLLRQVFQNLISNAIKYSRPGEppRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEYEGTGIGLAIVK 472
|
....*....
gi 2769203217 417 GVARLHGAR 425
Cdd:COG4251 473 KIVERHGGR 481
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
222-441 |
2.60e-24 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 104.32 E-value: 2.60e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 222 RSVTALRQVS-------SDIAHDLKTPVQRVSLQLEALQEVVKETQASELVAQT-RAEVEGIASVFQSLLQLAQVENGAL 293
Cdd:PRK11006 192 RDVTQMHQLEgarrnffANVSHELRTPLTVLQGYLEMMQDQPLEGALREKALHTmREQTQRMEGLVKQLLTLSKIEAAPT 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 294 QAAFAPVDLAqlclTMVDVYEPSAQ---NAGQTISCDVAPDVQVMGEKNLLGQMIANLLENALRHSGTGSKISLSLVCRA 370
Cdd:PRK11006 272 IDLNEKVDVP----MMLRVLEREAQtlsQGKHTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVP 347
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2769203217 371 GTAELTVADTGPGIPEEERARVVQRLYRLD--RSRNTPGNGLGLSLVDGVARLHGARLNFgDANPGLRVCVSF 441
Cdd:PRK11006 348 QGAEFSVEDNGPGIAPEHIPRLTERFYRVDkaRSRQTGGSGLGLAIVKHALSHHDSRLEI-ESEVGKGTRFSF 419
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
105-434 |
9.28e-24 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 101.80 E-value: 9.28e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 105 IISLEEGRATLNGEYLALSARLYGGRLTIARSRAEIEALQPVFLNILWISLLPTVLIALSGGLILARRSQRHVEVIRAAL 184
Cdd:COG4191 4 LLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 185 ERITGGNLGARVVTGKRWSDDLVRIGGAVNTMADAQERSVTALR----------------QVSSDIAHDLKTPVQRVSLQ 248
Cdd:COG4191 84 LLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRelqeqlvqseklaalgELAAGIAHEINNPLAAILGN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 249 LEALQEVVKET----QASELVAQTRAEVEGIASVFQSLLQLAQVENGALQaafaPVDLAQLCLTMVDVYEPSAQNAGQTI 324
Cdd:COG4191 164 AELLRRRLEDEpdpeELREALERILEGAERAAEIVRSLRAFSRRDEEERE----PVDLNELIDEALELLRPRLKARGIEV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 325 SCDVAPDV-QVMGEKNLLGQMIANLLENALR--HSGTGSKISLSLVCRAGTAELTVADTGPGIPEEERARV--------- 392
Cdd:COG4191 240 ELDLPPDLpPVLGDPGQLEQVLLNLLINAIDamEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIfepffttkp 319
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 2769203217 393 VQRlyrldrsrntpGNGLGLSLVDGVARLHGARLNFgDANPG 434
Cdd:COG4191 320 VGK-----------GTGLGLSISYGIVEKHGGRIEV-ESEPG 349
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
153-422 |
2.04e-23 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 102.16 E-value: 2.04e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 153 ISLLPTVLIalsggLILARRSQRHVEVIRAALERITGGNLGARVvTGKRWSDDLVRIGGAVNTMADAQERSVTALRQVSS 232
Cdd:PRK09835 194 ISLLIVFIV-----LLAVHKGHAPIRSVSRQIQNITSKDLDVRL-DPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSA 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 233 DIAHDLKTPVQRVSLQLE-ALQEVVKETQASELVAQTRAEVEGIASVFQSLLQLAQVENGALQAAFAPVDLAQLCLTMVD 311
Cdd:PRK09835 268 DIAHEIRTPITNLITQTEiALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLADEVGKVFD 347
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 312 VYEPSAQNAGQTISCDVAPdVQVMGEKNLLGQMIANLLENALRHSGTGSKISLSLVCRAGTAELTVADTGPGIPEEERAR 391
Cdd:PRK09835 348 FFEAWAEERGVELRFVGDP-CQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPR 426
|
250 260 270
....*....|....*....|....*....|...
gi 2769203217 392 VVQRLYRLD--RSRNTPGNGLGLSLVDGVARLH 422
Cdd:PRK09835 427 LFDRFYRVDpsRQRKGEGSGIGLAIVKSIVVAH 459
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
301-441 |
2.71e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 91.92 E-value: 2.71e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 301 DLAQLCLTMVDVYepsaQNAGQTISCDVAPDVQVMGEKNLLGQMIANLLENALRHSGtgSKISLSLVCRAGTAELTVADT 380
Cdd:cd16954 2 LLDSLCSALNKVY----QRKGVSISLDISPELRFPGERNDLMELLGNLLDNACKWCL--EFVEVTARQTDGGLHLIVDDD 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2769203217 381 GPGIPEEERARVVQRLYRLDRSRntPGNGLGLSLVDGVARLHGARLNFGDANPG-LRVCVSF 441
Cdd:cd16954 76 GPGVPESQRSKIFQRGQRLDEQR--PGQGLGLAIAKEIVEQYGGELSLSDSPLGgARFEVVF 135
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
336-443 |
8.58e-21 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 87.04 E-value: 8.58e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 336 GEKNLLGQMIANLLENALRHSGTGSKISLSLVcRAGTAELTVADTGPGIPEEERARVVQRLYRLDrSRNTPGNGLGLSLV 415
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPFSTAD-KRGGGGTGLGLSIV 78
|
90 100
....*....|....*....|....*...
gi 2769203217 416 DGVARLHGARLNFGDAnPGLRVCVSFEP 443
Cdd:pfam02518 79 RKLVELLGGTITVESE-PGGGTTVTLTL 105
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-441 |
7.00e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 81.74 E-value: 7.00e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 341 LGQMIANLLENALRHSGTGSKISLSLVCRAGTAELTVADTGPGIPEEERARVVQRLYRLDRSRN--TPGNGLGLSLVDGV 418
Cdd:cd16946 5 LQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNraSGGSGLGLAICHNI 84
|
90 100
....*....|....*....|....*
gi 2769203217 419 ARLHGARLNFgDANP--GLRVCVSF 441
Cdd:cd16946 85 ALAHGGTISA-EHSPlgGLRLVLTL 108
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
347-434 |
7.28e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 78.63 E-value: 7.28e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 347 NLLENALRHSGtgSKISLSLVCRAGTAELTVADTGPGIPEEERARVVQRLYRLD--RSRNTPGNGLGLSLVDGVARLHGA 424
Cdd:cd16939 7 NLLRNALRYAH--RTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDpsRDRATGGFGLGLAIVHRVALWHGG 84
|
90
....*....|
gi 2769203217 425 RLNFGDANPG 434
Cdd:cd16939 85 HVECDDSELG 94
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
206-441 |
3.23e-17 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 83.53 E-value: 3.23e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 206 LVRiggAVNTMADAQERSVTALRQVSSDIAHDLKTPvqrvslqLEALQEVVKETQASELVAQTRAE---VEGIASVFQSL 282
Cdd:PRK10815 248 LVR---NLNRLLKNERERYTKYRTTLTDLTHSLKTP-------LAVLQSTLRSLRSGKQMSVEQAEpimLEQISRISQQI 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 283 ---LQLAQV--ENGALQAAFAPVD--LAQLCLTMVDVYepsaQNAGQTISCDVAPDVQVMGEKNLLGQMIANLLENALRH 355
Cdd:PRK10815 318 gyyLHRASMrsEHNLLSRELHSVAplLDNLTSALNKVY----QRKGVNITLDISPEITFVGEKNDFMEVMGNVLDNACKY 393
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 356 SGTGSKISlslVCRAGTA-ELTVADTGPGIPEEERARVVQRLYRLDRSRntPGNGLGLSLVDGVARLHGARLNFGDANP- 433
Cdd:PRK10815 394 CLEFVEIS---ARQTDEHlHIVVEDDGPGIPESKRELIFDRGQRADTLR--PGQGLGLSVAREITEQYEGKISAGDSPLg 468
|
....*...
gi 2769203217 434 GLRVCVSF 441
Cdd:PRK10815 469 GARMEVIF 476
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
144-422 |
3.31e-17 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 83.44 E-value: 3.31e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 144 QPVFLNIL----WISLLPTVLIALSGGLILARRSQRHVEVIRAALERITGGNLGA--RVVTGKRwsdDLVRIGGAVNTMA 217
Cdd:PRK09470 157 QSDFINLLfdrpLLLLLVTMLVSTPLLLWLAWSLAKPARKLKNAADEVAQGNLRQhpELETGPQ---EFRQAGASFNQMV 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 218 DAQERSVTALRQVSSDIAHDLKTPVQRvsLQLEALQEVVKETQASELvaqTRAEVEG--IASVFQSLLQLA--QVENGAL 293
Cdd:PRK09470 234 TALERMMTSQQRLLSDISHELRTPLTR--LQLATALLRRRQGESKEL---ERIETEAqrLDSMINDLLVLSrnQQKNHLE 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 294 QAAFAPVDLAQlcltmvDVYEPSAQNAGQ-----TISCDVAPDVqVMGEKNLLGQMIANLLENALRHSGtgSKISLSLVC 368
Cdd:PRK09470 309 RETFKANSLWS------EVLEDAKFEAEQmgkslTVSAPPGPWP-INGNPNALASALENIVRNALRYSH--TKIEVAFSV 379
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 2769203217 369 RAGTAELTVADTGPGIPEEERARVVQRLYRLD--RSRNTPGNGLGLSLVDGVARLH 422
Cdd:PRK09470 380 DKDGLTITVDDDGPGVPEEEREQIFRPFYRVDeaRDRESGGTGLGLAIVENAIQQH 435
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
340-434 |
1.58e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 74.80 E-value: 1.58e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 340 LLGQMIANLLENALRHSGTGSKISLSLVCRAGTAELTVADTGPGIPEEERARVVQRLYRLDRSRN-TPGNGLGLSLVDGV 418
Cdd:cd16945 4 LLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSgQKSTGLGLAFVQEV 83
|
90
....*....|....*.
gi 2769203217 419 ARLHGARLNFGDANPG 434
Cdd:cd16945 84 AQLHGGRITLRNRPDG 99
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-427 |
3.22e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 74.16 E-value: 3.22e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 345 IANLLENALRHSGTGSKISLSLVCRAGTAELTVADTGPGIPEEERARVVQRLYRLD--RSRNTPGNGLGLSLVDGVARLH 422
Cdd:cd16952 5 FSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDieRCRNTGGTGLGLAIVKHVMSRH 84
|
....*
gi 2769203217 423 GARLN 427
Cdd:cd16952 85 DARLL 89
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
226-440 |
4.17e-16 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 79.51 E-value: 4.17e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 226 ALRQVSSDIAHDLKTPVQRVSLQLEALQEVVKETQASELVAQTRAEVEGIASVFQSLLQLAQVEngalQAAFAPVDLAQL 305
Cdd:COG3852 134 AVGELAAGLAHEIRNPLTGIRGAAQLLERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPR----PPEREPVNLHEV 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 306 CLTMVDVYEPSAqNAGQTISCDVAPDV-QVMGEKNLLGQMIANLLENALRHSGTGSKISLSLVCRAGT----------AE 374
Cdd:COG3852 210 LERVLELLRAEA-PKNIRIVRDYDPSLpEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQVtlgglrprlyVR 288
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2769203217 375 LTVADTGPGIPEEERARVvqrlyrldrsrNTP-------GNGLGLSLVDGVARLHGARLNFgDANPGLRVCVS 440
Cdd:COG3852 289 IEVIDNGPGIPEEILDRI-----------FEPffttkekGTGLGLAIVQKIVEQHGGTIEV-ESEPGKGTTFR 349
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-437 |
4.98e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 73.51 E-value: 4.98e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 341 LGQMIANLLENALRHSGtgSKISLSLVCRAGTAELTVADTGPGIPEEERARVVQRLYRLD--RSRNTPGNGLGLSLVDGV 418
Cdd:cd16949 1 LARALENVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDsaRDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|
gi 2769203217 419 ARLHGARLNFGDANP-GLRV 437
Cdd:cd16949 79 IEQHGGKIKASNRKPgGLRV 98
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-427 |
4.89e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 70.49 E-value: 4.89e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 341 LGQMIANLLENALRHSGTGSKISLSLVCRAGTAELTVADTGPGIPEEERARVVQRLYRLDRSRNTPGNGLGLSLVDGVAR 420
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTEGAGLGLSIAKAIIE 80
|
....*..
gi 2769203217 421 LHGARLN 427
Cdd:cd16923 81 LHGGSAS 87
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
341-434 |
8.70e-15 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 70.21 E-value: 8.70e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 341 LGQMIANLLENALRHSGTGSKISLSL-VCRAGTAELTVADTGPGIPEEERARVVQRLYRL--DRSRNTPGNGLGLSLVDG 417
Cdd:cd16925 5 YERVVLNLLSNAFKFTPDGGRIRCILeKFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGdgSSTRAHGGTGLGLSIVKE 84
|
90
....*....|....*..
gi 2769203217 418 VARLHGARLNFGDANPG 434
Cdd:cd16925 85 FVELHGGTVTVSDAPGG 101
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
220-425 |
3.59e-13 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 71.54 E-value: 3.59e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 220 QERsVTALRQVSSDIAHDLKTPVQRVSLQLEALQEVVKETQASELVAQTRAEVEGIASVFQSLLQLAQVEngalQAAFAP 299
Cdd:PRK11360 384 QER-LAALGELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPR----ESQWQP 458
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 300 VDLAQLCLTMVDVYEPSAQNAGQTISCDVAPDV-QVMGEKNLLGQMIANLLENALRHSGTGSKISLSL-VCRAGTAELTV 377
Cdd:PRK11360 459 VSLNALVEEVLQLFQTAGVQARVDFETELDNELpPIWADPELLKQVLLNILINAVQAISARGKIRIRTwQYSDGQVAVSI 538
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 2769203217 378 ADTGPGIPEEERARVVQRLYrldrSRNTPGNGLGLSLVDGVARLHGAR 425
Cdd:PRK11360 539 EDNGCGIDPELLKKIFDPFF----TTKAKGTGLGLALSQRIINAHGGD 582
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-434 |
5.78e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 64.78 E-value: 5.78e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 341 LGQMIANLLENALRHSGTGSKISlSLVCRAGTAeLTVADTGPGIPEEERARVVQRLYRLDRSRNTPGNGLGLSLVDGVAR 420
Cdd:cd16950 1 LKRVLSNLVDNALRYGGGWVEVS-SDGEGNRTR-IQVLDNGPGIAPEEVDELFQPFYRGDNARGTSGTGLGLAIVQRISD 78
|
90
....*....|....
gi 2769203217 421 LHGARLNFGDANPG 434
Cdd:cd16950 79 AHGGSLTLANRAGG 92
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
233-442 |
1.50e-12 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 69.67 E-value: 1.50e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 233 DIAHDLKTPVQRVSLQLEALQEVVKETQASELVAQTRAEVEGIASVFQSLLQLAQVENGALQAAFAPVDLAQLC-LTMVD 311
Cdd:PRK15347 404 TISHEIRTPLNGVLGALELLQNTPLTAEQMDLADTARQCTLSLLAIINNLLDFSRIESGQMTLSLEETALLPLLdQAMLT 483
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 312 VYEPsAQNAGQTISCDVAPDV-QVMGEKNL-LGQMIANLLENALRHSGTGSkISLSLVCRAGTAELTVADTGPGIPEEER 389
Cdd:PRK15347 484 IQGP-AQSKSLTLRTFVGAHVpLYLHLDSLrLRQILVNLLGNAVKFTETGG-IRLRVKRHEQQLCFTVEDTGCGIDIQQQ 561
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 2769203217 390 ARVVQRLYRLDrsRNTPGNGLGLSLVDGVARLHGARLNFgDANPGLRVCVSFE 442
Cdd:PRK15347 562 QQIFTPFYQAD--THSQGTGLGLTIASSLAKMMGGELTL-FSTPGVGSCFSLV 611
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
143-441 |
1.96e-12 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 68.78 E-value: 1.96e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 143 LQPVFLNILWISLLptvliALSGGLILARRSQRHVEVIRAALERITGGNLGARVvtGKRWSDDLVRIGGAVNTMAdaqeR 222
Cdd:PRK09467 152 FSPLFRYTLAIGLL-----SVAGGWLFIRIQNRPLVALEHAALQVGKGEIPPPL--REYGASEVRSVTRAFNQMA----A 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 223 SVTALRQ----VSSDIAHDLKTPVQRVSLQLEALQE--------VVKETQaselvaqtraEVEGIASVFQSLLQLAQven 290
Cdd:PRK09467 221 GIKQLEDdrtlLMAGVSHDLRTPLTRIRLATEMMSEedgylaesINKDIE----------ECNAIIEQFIDYLRTGQ--- 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 291 galQAAFAPVDLAQLcltMVDVYEpSAQNAGQTISCDVAPdvqvmGEKNLLGQMIA------NLLENALRHsGTG----- 359
Cdd:PRK09467 288 ---EMPMEMADLNAL---LGEVIA-AESGYEREIETALQP-----GPIEVPMNPIAikralaNLVVNAARY-GNGwikvs 354
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 360 SKISLSLVCragtaeLTVADTGPGIPEEERARVVQRLYRLDRSRNTPGNGLGLSLVDGVARLHGARLNFGD-ANPGLRVC 438
Cdd:PRK09467 355 SGTEGKRAW------FQVEDDGPGIPPEQLKHLFQPFTRGDSARGSSGTGLGLAIVKRIVDQHNGKVELGNsEEGGLSAR 428
|
...
gi 2769203217 439 VSF 441
Cdd:PRK09467 429 AWL 431
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
330-419 |
2.94e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 63.30 E-value: 2.94e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 330 PD--VQVMGEKNLLGQMIANLLENALRHSGTGSKISLSLVCRAGTAELTVADTGPGIPEEERARVVQRLYRLDRSRNT-- 405
Cdd:cd16947 8 PDrpIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSak 87
|
90
....*....|....
gi 2769203217 406 PGNGLGLSLVDGVA 419
Cdd:cd16947 88 QGNGLGLTITKRLA 101
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
341-442 |
6.85e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 61.74 E-value: 6.85e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 341 LGQMIANLLENALRHSGTGSkISLSLVCRAGTAE-----LTVADTGPGIPEEERARVVQRLYRLDRS--RNTPGNGLGLS 413
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGE-VTLRVSLEEEEEDgvqlrFSVEDTGIGIPEEQQARLFEPFSQADSSttRKYGGTGLGLA 79
|
90 100
....*....|....*....|....*....
gi 2769203217 414 LVDGVARLHGARLNFgDANPGLRVCVSFE 442
Cdd:cd16922 80 ISKKLVELMGGDISV-ESEPGQGSTFTFT 107
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
234-426 |
7.66e-12 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 67.37 E-value: 7.66e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 234 IAHDLKTPVQRVSLQLEAL-QEVVKE-----TQASELvaqtRAEVEGIASVFQSLLQLAQVENGALQAAFAPVDLAQLCL 307
Cdd:PRK10490 671 LSHDLRTPLTVLFGQAEILtLDLASEgsphaRQASEI----RQQVLNTTRLVNNLLDMARIQSGGFNLRKEWLTLEEVVG 746
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 308 TMVDVYEPSAqnAGQTISCDVAPDVQ-VMGEKNLLGQMIANLLENALRHSGTGSKISLSLVCRAGTAELTVADTGPGIPE 386
Cdd:PRK10490 747 SALQMLEPGL--SGHPINLSLPEPLTlIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGERLQLDVWDNGPGIPP 824
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 2769203217 387 EERARVVQRLYRLDRSRNTPGNGLGLSLVDGVARLHGARL 426
Cdd:PRK10490 825 GQEQLIFDKFARGNKESAIPGVGLGLAICRAIVEVHGGTI 864
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
324-441 |
2.14e-11 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 65.26 E-value: 2.14e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 324 ISCDVAPDVQVMGEK---NLLGQMIANLLENALRHSGTGS----KISLSLVCRAGTAELTVADTGPGIPEEERARVVQRL 396
Cdd:COG3290 262 IDLTIDIDSDLPDLPlsdTDLVTILGNLLDNAIEAVEKLPeeerRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERG 341
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 2769203217 397 YrldRSRNTPGNGLGLSLVDGVARLHGARLNFGDANP-GLRVCVSF 441
Cdd:COG3290 342 F---STKLGEGRGLGLALVKQIVEKYGGTIEVESEEGeGTVFTVRL 384
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
223-435 |
2.85e-11 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 65.91 E-value: 2.85e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 223 SVTALRQVSSDIAHDLKTPVQRVSLQLEALQ-EVVKETQASELVAQTRAEVEGIASVFQSLLQLAQVENGALQAAFAPVD 301
Cdd:PRK09959 708 ATVAKSQFLATMSHEIRTPISSIMGFLELLSgSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVD 787
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 302 LAQLCLTMVDVYEPSAQNAGQTISCDVA-PDVQVMG-EKNLLGQMIANLLENALRHSGTGS-KISLSLVC---RAGTAEL 375
Cdd:PRK09959 788 IPTLVQNTCHSFGAIAASKSIALSCSSTfPDHYLVKiDPQAFKQVLSNLLSNALKFTTEGAvKITTSLGHiddNHAVIKM 867
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 376 TVADTGPGIPEEERARVVQRLYRLDRSRNTPGNGLGLSLVDGVARLHGARLNFgDANPGL 435
Cdd:PRK09959 868 TIMDSGSGLSQEEQQQLFKRYSQTSAGRQQTGSGLGLMICKELIKNMQGDLSL-ESHPGI 926
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
234-428 |
4.20e-10 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 61.53 E-value: 4.20e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 234 IAHDLKTPVQRVS--LQLeaLQEVVKETQAS--ELVaqtRAEVEGIASVFQSLLQLAQveNGALQaaFAPVDLAQLCLTM 309
Cdd:COG5809 277 IAHEIRNPLTSLKgfIQL--LKDTIDEEQKTylDIM---LSELDRIESIISEFLVLAK--PQAIK--YEPKDLNTLIEEV 347
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 310 VDVYEPSAQNAGQTISCDVAPDV-QVMGEKNLLGQMIANLLENALRHSGTGSKISLSLVCRAGTA-ELTVADTGPGIPEE 387
Cdd:COG5809 348 IPLLQPQALLKNVQIELELEDDIpDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDDDKvVISVTDEGCGIPEE 427
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 2769203217 388 ERARVVQRLYrldrSRNTPGNGLGLSLVDGVARLHGARLNF 428
Cdd:COG5809 428 RLKKLGEPFY----TTKEKGTGLGLMVSYKIIEEHGGKITV 464
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
343-434 |
8.87e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 55.54 E-value: 8.87e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 343 QMIANLLENALR--HSGTGSKISLSLVCRAGTAELTVADTGPGIPEEERARVVQRLYRLDRSRNtpGNGLGLSLVDGVAR 420
Cdd:cd16976 3 QVLMNLLQNALDamGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGK--GTGLGLSISYGIVE 80
|
90
....*....|....
gi 2769203217 421 LHGARLNFGDANPG 434
Cdd:cd16976 81 EHGGRLSVANEEGA 94
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
344-434 |
2.62e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 54.22 E-value: 2.62e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 344 MIANLLENAL----RHSGTGSKISLSLVCRAGTAELTVADTGPGIPEEERARVVQRLYrldRSRNTPGNGLGLSLVDGVA 419
Cdd:cd16915 4 IVGNLIDNALdalaATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGV---STKGQGERGIGLALVRQSV 80
|
90
....*....|....*
gi 2769203217 420 RLHGARLNFGDANPG 434
Cdd:cd16915 81 ERLGGSITVESEPGG 95
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
3-441 |
7.81e-09 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 57.61 E-value: 7.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 3 ALWRSMPLRLALVLVLLFGTVSLLSLAASYAFTRAAFEQSIRDDLAQDLAGFRAAPSARAVAVLVQAESADTDPGRLVLS 82
Cdd:COG3920 57 ALSAAALAAALAVALAAAVGAAAALLALLVLLLLLLLAAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLL 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 83 YASPSGRIYGNGAVARDDEGFHIISLEEGRATLNGEYLALSARLYGGRLTIARSRAEIEALQPVFLNILWISLLPTVLIA 162
Cdd:COG3920 137 LLLLLAILALAELAVALAELAAALLLLAEELAALRLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLL 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 163 LSGGLILARRSQRHVEVIRAALERITGGNLGARVVTGKRWSDDLVRIGGAVNTMADAQERSVTALRQVSSDIAHDLKtpv 242
Cdd:COG3920 217 LLLLALLLVLLAALLRLRAAVLEELERRRRARGLGRLLLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLE--- 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 243 qrvslQLEAL-QEV---------------------VKETQASELVAQTRAEVEGIASVFQSLLQlaqvengalQAAFAPV 300
Cdd:COG3920 294 -----EKELLlRELhhrvknnlqvvssllrlqarrADDPEAREALEESQNRIQALALVHELLYQ---------SEDWEGV 359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 301 DLAQLCLTMVDVYEPSAQNAGQTISCDVaPDVQVMGEKNL-LGqMIAN-LLENALRH---SGTGSKISLSLVCRAGTAEL 375
Cdd:COG3920 360 DLRDYLRELLEPLRDSYGGRGIRIELDG-PDVELPADAAVpLG-LILNeLVTNALKHaflSGEGGRIRVSWRREDGRLRL 437
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2769203217 376 TVADTGPGIPEEERARVvqrlyrldrsrntpGNGLGLSLVDGVARLHGARLNFgDANPGLRVCVSF 441
Cdd:COG3920 438 TVSDNGVGLPEDVDPPA--------------RKGLGLRLIRALVRQLGGTLEL-DRPEGTRVRITF 488
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
339-442 |
1.49e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 52.46 E-value: 1.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 339 NLLGQMIANLLENALRHSGTGSKISLSLVCRAGTAELTVADTGPGIPEEERARVVQRLYRLDRSRNTPGN-GLGLSLVDG 417
Cdd:cd16975 3 LLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGHyGMGLYIAKN 82
|
90 100
....*....|....*....|....*
gi 2769203217 418 VARLHGARLNFGDANPGlRVCVSFE 442
Cdd:cd16975 83 LVEKHGGSLIIENSQKG-GAEVTVK 106
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-441 |
4.22e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 50.79 E-value: 4.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 341 LGQMIANLLENALRHSGTGSKISLSLVCR--AGTAELTVADTGPGIPEEERARVVQRLYRLDRSRNTPGNGLGLSLVDGV 418
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEdvGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEYEGTGVGLAIVRKI 80
|
90 100
....*....|....*....|...
gi 2769203217 419 ARLHGARLnFGDANPGLRVCVSF 441
Cdd:cd16921 81 IERHGGRI-WLESEPGEGTTFYF 102
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
118-431 |
5.60e-08 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 54.64 E-value: 5.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 118 EYLALSARLYGGRLTIARSRAEIEALQPVFLNILWISLLPTVLIALSGGLILARRSQRHVEVIRAALERITGGNLGARVV 197
Cdd:COG2972 126 LIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVRLEV 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 198 TGKrwsDDLVRIGGAVNTMADAQERSVTALRQVSsdiahdlktpVQRVSLQLEALQevvketqaselvAQ---------- 267
Cdd:COG2972 206 SGN---DEIGILARSFNEMVERIKELIEEVYELE----------LEKKEAELKALQ------------AQinphflfntl 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 268 ----TRAEVEGIASVFQSLLQLAQVENGALQAAFAPVDLAQ---LC---LTMvdvyepsaQN--AGQ--TISCDVAPDvq 333
Cdd:COG2972 261 nsirWLAELEDPEEAEEMLEALSKLLRYSLSKGDELVTLEEeleLIksyLEI--------QKlrFGDrlEVEIEIDEE-- 330
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 334 vmgeknLLGQMIANLL-----ENALRH----SGTGSKISLSLVCRAGTAELTVADTGPGIPEEERARVVQRLyrldrSRN 404
Cdd:COG2972 331 ------LLDLLIPKLIlqplvENAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-----SSK 399
|
330 340
....*....|....*....|....*..
gi 2769203217 405 TPGNGLGLSLVDgvARLhgaRLNFGDA 431
Cdd:COG2972 400 GEGRGIGLRNVR--ERL---KLYYGEE 421
|
|
| nifL_nitrog |
TIGR02938 |
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ... |
219-442 |
5.75e-08 |
|
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]
Pssm-ID: 131984 [Multi-domain] Cd Length: 494 Bit Score: 54.91 E-value: 5.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 219 AQERSVTALRQVSSDIAHDLKTPVQRVSLQLEALQEVVKETQASELVAQTRaevEGIASVFQSLLQLAQVENGALQAAFA 298
Cdd:TIGR02938 268 AEEERLEAIRETLSAAIHRLQGPMNLISAAISVLQRRGDDAGNPASAAMLQ---QALSAGREHMEALRQVIPQSPQEIVV 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 299 PVDLAQLCLTMVDVYEPSAQNAGQTISCDVAPDV-QVMGEKNLLGQMIANLLENA---LRHSGTGSK-ISLSLVCRAGTA 373
Cdd:TIGR02938 345 PVNLNQILRDVITLSTPRLLAAGIVVDWQPAATLpAILGRELQLRSLFKALVDNAieaMNIKGWKRReLSITTALNGDLI 424
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 374 ELTVADTGPGIPEEERARVVQRLYRLDRSRNTpGNGLGLSLVDGVARLHGARLNFG-DANPGLRVCVSFE 442
Cdd:TIGR02938 425 VVSILDSGPGIPQDLRYKVFEPFFTTKGGSRK-HIGMGLSVAQEIVADHGGIIDLDdDYSEGCRIIVEFR 493
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-433 |
7.37e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 50.65 E-value: 7.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 341 LGQMIANLLENALRHS--GTGsKISLSLVCRAGTAELTVADTGPGIPEEERARVVQRLYRlDRSRNTP---GNGLGLSLV 415
Cdd:cd16953 1 LGQVLRNLIGNAISFSppDTG-RITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYT-ERPANEAfgqHSGLGLSIS 78
|
90
....*....|....*...
gi 2769203217 416 DGVARLHGARLNFGDANP 433
Cdd:cd16953 79 RQIIEAHGGISVAENHNQ 96
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
323-417 |
1.83e-07 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 53.44 E-value: 1.83e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 323 TISCDVAPDV--QVMGEKNLLGQMIANLLENALRHSGTGSkISLSLVCRAGTAELTVADTGPGIPEEERARVVQRLYRL- 399
Cdd:PRK10841 543 GLYCFIEPDVpvALNGDPMRLQQVISNLLSNAIKFTDTGC-IVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVg 621
|
90 100
....*....|....*....|....*.
gi 2769203217 400 -DRSRNTPGNGLGL-------SLVDG 417
Cdd:PRK10841 622 tGVQRNFQGTGLGLaicekliNMMDG 647
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
220-423 |
1.85e-07 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 53.25 E-value: 1.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 220 QERSVtALRQVSSDIAHDLKTPVQRVSLQLEALQEVVKE-TQASELVAQTRAEVEGIASVFQSLLQLAQVENGALQaafa 298
Cdd:PRK10364 231 KEKLV-ALGHLAAGVAHEIRNPLSSIKGLAKYFAERAPAgGEAHQLAQVMAKEADRLNRVVSELLELVKPTHLALQ---- 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 299 PVDLAQLCLTMVDVYEPSAQNAGQTISCDVAPDVQ-VMGEKNLLGQMIANLLENALRHSGTGSKISLSLVCRAGTAELTV 377
Cdd:PRK10364 306 AVDLNDLINHSLQLVSQDANSREIQLRFTANDTLPeIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISV 385
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 2769203217 378 ADTGPGIPEEERARVVQRLYrldrSRNTPGNGLGLSLVDGVARLHG 423
Cdd:PRK10364 386 TDSGKGIAADQLEAIFTPYF----TTKAEGTGLGLAVVHNIVEQHG 427
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
226-291 |
2.30e-07 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 47.59 E-value: 2.30e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2769203217 226 ALRQVSSDIAHDLKTPVQRVSLQLEALQEVVKETQASELVAQTRAEVEGIASVFQSLLQLAQVENG 291
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
229-441 |
2.79e-07 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 52.81 E-value: 2.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 229 QVSSDIAHDLKTPVQRVS--LQLeaLQeVVKETQaSELVAQTRAEVEGIASVFQSLLQLAQveNGALQaaFAPVDLAQLC 306
Cdd:COG5805 289 QLAAGIAHEIRNPLTSIKgfLQL--LQ-PGIEDK-EEYFDIMLSELDRIESIISEFLALAK--PQAVN--KEKENINELI 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 307 LTMVDVYEPSAQNAGQTISCDV-APDVQVMGEKNLLGQMIANLLENALRHSGTGSKISLSLVCRAGTAELTVADTGPGIP 385
Cdd:COG5805 361 QDVVTLLETEAILHNIQIRLELlDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIP 440
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2769203217 386 EEerarvvqRLYRLdrsrNTP-------GNGLGLSLVDGVARLHGARLNFgDANPGL--RVCVSF 441
Cdd:COG5805 441 EE-------RLKKL----GEPffttkekGTGLGLMVSYKIIENHNGTIDI-DSKVGKgtTFTITL 493
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
343-434 |
3.44e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 48.55 E-value: 3.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 343 QMIANLLEN---ALRHSGTGSKISLSLVCRAGTAELT--VADTGPGIPEEERARVVQRLYrldrSRNTPGNGLGLSLVDG 417
Cdd:cd16920 3 QVLINLVRNgieAMSEGGCERRELTIRTSPADDRAVTisVKDTGPGIAEEVAGQLFDPFY----TTKSEGLGMGLSICRS 78
|
90
....*....|....*..
gi 2769203217 418 VARLHGARLNFGDANPG 434
Cdd:cd16920 79 IIEAHGGRLSVESPAGG 95
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
153-413 |
8.57e-07 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 51.23 E-value: 8.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 153 ISLLPTVLIALSGGLILA-----RRSQRHVEVIRAALERITGGNLGARV-VTGKrwsDDLVRIGGAV------------- 213
Cdd:COG4192 326 ILLLAIALLSLLLAVLINyfyvrRRLVKRLNALSDAMAAIAAGDLDVPIpVDGN---DEIGRIARLLrvfrdqaiektqe 402
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 214 -NTMADAQERSVTALRQVSSD----------------IAHDLKTPVQRVSLQLEALQEVVKE---TQASELVAQTRAEVE 273
Cdd:COG4192 403 lETEIEERKRIEKNLRQTQDEliqaakmavvgqtmtsLAHELNQPLNAMSMYLFSAKKALEQenyAQLPTSLDKIEGLIE 482
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 274 GIASVFQSLLQLAQVENGALQaafaPVDLAQLCLTMVDVYEPSAQNagQTISCDVAPDVQVMGEKNLLGQMIANLLENAL 353
Cdd:COG4192 483 RMDKIIKSLRQFSRKSDTPLQ----PVDLRQVIEQAWELVESRAKP--QQITLHIPDDLMVQGDQVLLEQVLVNLLVNAL 556
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 354 RHSGTGSKISLSLVCRAGTAELTVADTGPGIPeeerarVVQRLYRLDRSRNTPGNGLGLS 413
Cdd:COG4192 557 DAVATQPQISVDLLSNAENLRVAISDNGNGWP------LVDKLFTPFTTTKEVGLGLGLS 610
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
221-435 |
1.00e-06 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 51.09 E-value: 1.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 221 ERSVTALRQVSSDIAHDLKTPVQRVSLQLEALQEVVKETQASELVAQTRAEVEGIASVFQSLLQLAQVENGALQAAFAPV 300
Cdd:PRK10618 444 EKNQQARKAFLQNIGDELKQPLQSLAQLAAQLRQTSDEEQQQPELDQLAEQSDVLVRLVDNIQLLNMLETQDWKPEQELF 523
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 301 DLAQLCLTMVDVYEPSAQNAGQT--ISCDVAPDVQVMGEKNLLGQMIANLLENALRHSGTGsKISLSlVCRAGTAE---- 374
Cdd:PRK10618 524 SLQDLIDEVLPEVLPAIKRKGLQllIHNHLKAEQLRIGDRDALRKILLLLLNYAITTTAYG-KITLE-VDQDESSPdrlt 601
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2769203217 375 LTVADTGPGIPEEERARVVQR-LYRLDRSRNTPGNGLGLSLVDGVARLHGARLNFgDANPGL 435
Cdd:PRK10618 602 IRILDTGAGVSIKELDNLHFPfLNQTQGDRYGKASGLTFFLCNQLCRKLGGHLTI-KSREGL 662
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
226-291 |
2.35e-06 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 44.86 E-value: 2.35e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2769203217 226 ALRQVSSDIAHDLKTPVQRVSLQLEALQEVVKETQASELVAQTRAEVEGIASVFQSLLQLAQVENG 291
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
315-412 |
2.57e-06 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 49.85 E-value: 2.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 315 PSAQNAGQTISCDVAPDV--QVMGEKNLLGQMIANLLENALRHSGTGSkISLSLVCRAGTA-----ELTVADTGPGIPEE 387
Cdd:PRK11107 381 HSAHEKGLELTLNIDPDVpdNVIGDPLRLQQIITNLVGNAIKFTESGN-IDILVELRALSNtkvqlEVQIRDTGIGISER 459
|
90 100
....*....|....*....|....*..
gi 2769203217 388 ERARVVQRLYRLDRS--RNTPGNGLGL 412
Cdd:PRK11107 460 QQSQLFQAFRQADASisRRHGGTGLGL 486
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-434 |
5.05e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 45.08 E-value: 5.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 341 LGQMIANLLENALRH-SGTGSKISLS---------------LVCRagtaeLTVADTGPGIPEEERARVvqrLYRLDRSRN 404
Cdd:cd16918 1 LIQVFLNLVRNAAQAlAGSGGEIILRtrtqrqvtlghprhrLALR-----VSVIDNGPGIPPDLQDTI---FYPMVSGRE 72
|
90 100 110
....*....|....*....|....*....|
gi 2769203217 405 TpGNGLGLSLVDGVARLHGARLNFgDANPG 434
Cdd:cd16918 73 N-GTGLGLAIAQNIVSQHGGVIEC-DSQPG 100
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
323-415 |
5.34e-06 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 48.76 E-value: 5.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 323 TISCDV----APDVQVMGEknlLGQMIANLLENALRH-SGTGSK-ISLSLVCRAGTAELTVADTGPGIPEEERARVVQRL 396
Cdd:PRK11086 415 IISEDSqlpdSGDEDQVHE---LITILGNLIENALEAvGGEEGGeISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKG 491
|
90
....*....|....*....
gi 2769203217 397 YrldrSRNTPGNGLGLSLV 415
Cdd:PRK11086 492 Y----STKGSNRGVGLYLV 506
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
344-415 |
1.05e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 44.20 E-value: 1.05e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2769203217 344 MIANLLENALRHSGTGSKISLSLVCRAGTAELTVADTGPGIPEEERARVVQRLYRLDRSRNTP-GNGLGLSLV 415
Cdd:cd16948 9 IIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQeSTGMGLYLV 81
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
234-426 |
2.24e-05 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 46.82 E-value: 2.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 234 IAHDLKTPVQRV--SLQLEALQEvvketqaseLVAQTRAEVEGIASVFQSLLQL-------AQVENGALQAAFA--PVDL 302
Cdd:PRK11466 451 MSHEIRTPLYGIlgTAQLLADNP---------ALNAQRDDLRAITDSGESLLTIlndildySAIEAGGKNVSVSdePFEP 521
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 303 AQLCLTMVDVYEPSAQNAGQTISCDVAPDV--QVMGEKNLLGQMIANLLENALRHSGTGSkISLSLVCRAGTAELTVADT 380
Cdd:PRK11466 522 RPLLESTLQLMSGRVKGRPIRLATDIADDLptALMGDPRRIRQVITNLLSNALRFTDEGS-IVLRSRTDGEQWLVEVEDS 600
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 2769203217 381 GPGIPEEERARVVQRLYRLDRSRNtpGNGLGLSLVDGVARLHGARL 426
Cdd:PRK11466 601 GCGIDPAKLAEIFQPFVQVSGKRG--GTGLGLTISSRLAQAMGGEL 644
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-441 |
4.63e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 41.77 E-value: 4.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 349 LENALRHSGtGSKISLSLVCRAGTAELTVADTGPGIPEEERARvvqrlyrldrsrnTPGNGLgLSLVDGVARLHGaRLNF 428
Cdd:cd16917 9 LTNALKHAG-ASRVRVTLSYTADELTLTVVDDGVGFDGPAPPG-------------GGGFGL-LGMRERAELLGG-TLTI 72
|
90
....*....|....
gi 2769203217 429 GDANP-GLRVCVSF 441
Cdd:cd16917 73 GSRPGgGTRVTARL 86
|
|
| PRK13560 |
PRK13560 |
hypothetical protein; Provisional |
219-385 |
7.21e-05 |
|
hypothetical protein; Provisional
Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 45.43 E-value: 7.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 219 AQERSVTALRQ---VSSDIAHDLKTPVQRVSLQLEALQEVVKETQASELVAQTRAEVEGIASVFQsllQLAQVENgalqa 295
Cdd:PRK13560 594 AEEKIKAALTEkevLLKEIHHRVKNNLQIISSLLDLQAEKLHDEEAKCAFAESQDRICAMALAHE---KLYQSED----- 665
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 296 aFAPVDLAQLCLTMVD-VYEPSAQNAGQtISCDVAPDVQVMGEKNLL--GQMIANLLENALRHS---GTGSKISLSLVCR 369
Cdd:PRK13560 666 -LADIDFLDYIESLTAhLKNSFAIDFGR-IDCKIDADDGCLDIDKAIpcGLIISELLSNALKHAfpdGAAGNIKVEIREQ 743
|
170
....*....|....*..
gi 2769203217 370 A-GTAELTVADTGPGIP 385
Cdd:PRK13560 744 GdGMVNLCVADDGIGLP 760
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
226-287 |
7.91e-05 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 40.66 E-value: 7.91e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2769203217 226 ALRQVSSDIAHDLKTPVQRVSLQLEALQE-VVKETQASELVAQTRAEVEGIASVFQSLLQLAQ 287
Cdd:cd00082 3 AKGEFLANVSHELRTPLTAIRGALELLEEeLLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
22-287 |
1.03e-04 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 44.63 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 22 TVSLLSLAASYAFTRAAFEQSIRDDLAQDLAGFRAAPSARAVAVLVQAESADTDPGRLVLSYASPSGRIYGNGAVARDDE 101
Cdd:COG0840 55 LLLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLAL 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 102 GFHIISLEEGRATLNGEYLALSARLYGGRLTIARSRAEIEALQPVFLNILWISLLPTVLIALSGGLILARRSQRHVEVIR 181
Cdd:COG0840 135 AALLALAALALALLALALLAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELL 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 182 AALERITGGNLGARVVTGKRwsDDLVRIGGAVNTMADAQERSVTALRQVSSDIAHdlktpvqrVSLQLEALQEVVKE--T 259
Cdd:COG0840 215 EVLERIAEGDLTVRIDVDSK--DEIGQLADAFNRMIENLRELVGQVRESAEQVAS--------ASEELAASAEELAAgaE 284
|
250 260
....*....|....*....|....*...
gi 2769203217 260 QASELVAQTRAEVEGIASVFQSLLQLAQ 287
Cdd:COG0840 285 EQAASLEETAAAMEELSATVQEVAENAQ 312
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
375-426 |
1.40e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 41.21 E-value: 1.40e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 2769203217 375 LTVADTGPGIPEEERARVVQRLYrldrsrNTP----GNGLGLSLVDGVARLHGARL 426
Cdd:cd16919 50 LEVSDTGSGMPAEVLRRAFEPFF------TTKevgkGTGLGLSMVYGFVKQSGGHL 99
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
340-434 |
1.48e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 40.98 E-value: 1.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 340 LLGQMIANLLENAL-----RHSGTGSKISLSLVCRAGTAELTVADTGPGIPEEERARVVQRlYRLDRSRntpGNGLGLSL 414
Cdd:cd16944 4 QISQVLTNILKNAAeaiegRPSDVGEVRIRVEADQDGRIVLIVCDNGKGFPREMRHRATEP-YVTTRPK---GTGLGLAI 79
|
90 100
....*....|....*....|
gi 2769203217 415 VDGVARLHGARLNFGDANPG 434
Cdd:cd16944 80 VKKIMEEHGGRISLSNREAG 99
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
348-420 |
5.62e-04 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 38.79 E-value: 5.62e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2769203217 348 LLENALRHSGTGSK---ISLSLVCRAGTAELTVADTGPGIPEEERArvvqrlyrlDRSRNTPGNGLGLSLVDGVAR 420
Cdd:cd16936 8 AVTNAVRHAYRHDGpgpVRLELDLDPDRLRVEVTDSGPGFDPLRPA---------DPDAGLREGGRGLALIRALMD 74
|
|
| HATPase_YpdA-like |
cd16955 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
344-438 |
7.28e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340431 [Multi-domain] Cd Length: 102 Bit Score: 38.98 E-value: 7.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 344 MIANLLENALRH----SGTGSKISLSL-VCRAGTAELTVADTGPGIPEEERARVvqrlyrldRSRNTPGNGLGLSLVDGV 418
Cdd:cd16955 5 MIQPLVENAIVHgiqeKKGKGVVKISVkKQLKNRLHIAVEDNGIGISPKVIERV--------EQDEMPGNKIGLLNVHQR 76
|
90 100
....*....|....*....|..
gi 2769203217 419 ARL-HGARLN-FGDANPGLRVC 438
Cdd:cd16955 77 LKLgYGEGLHiRSRPDPGTLIA 98
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
348-419 |
1.14e-03 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 38.74 E-value: 1.14e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2769203217 348 LLENALRHSGTGS---KISLSLVCRAGTAELTVADTGPGIPEEERArvvqrlyrlDRSRNTPGNGLGLSLVDGVA 419
Cdd:COG2172 42 AVTNAVRHAYGGDpdgPVEVELELDPDGLEIEVRDEGPGFDPEDLP---------DPYSTLAEGGRGLFLIRRLM 107
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
348-430 |
1.56e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 37.81 E-value: 1.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 348 LLENALRHS-----GTGsKISLSLVCRAGTAELTVADTGPGIPEeeraRVVQRLYRLDRsrntPGNGLGLSLVDgvarlH 422
Cdd:cd16924 9 LVENAIQHGlspltDKG-VVTISALKEDNHVMIEVEDNGRGIDP----KVLNILGKKPK----EGNGIGLYNVH-----Q 74
|
....*...
gi 2769203217 423 GARLNFGD 430
Cdd:cd16924 75 RLILLFGE 82
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
340-423 |
2.73e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 37.40 E-value: 2.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 340 LLGQMIANLLENALRHSGTGSKISLSLVCRAGTAELTVADTGPGIPEEERARVVQRLYRLDRSRNtpGNGLGLSLVDGVA 419
Cdd:cd16943 3 QLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE--GTGLGLSLSYRII 80
|
....
gi 2769203217 420 RLHG 423
Cdd:cd16943 81 QKHG 84
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
331-427 |
5.32e-03 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 39.28 E-value: 5.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 331 DVQVMGEKNLLGQMIANLLENALRHSGTGSKISLSLVCRAGTAE---------------LTVADTGPGIPEEERARVVQr 395
Cdd:PRK13837 551 PAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAKLRAPkvlshgvlppgryvlLRVSDTGAGIDEAVLPHIFE- 629
|
90 100 110
....*....|....*....|....*....|..
gi 2769203217 396 LYRLDRSRntpGNGLGLSLVDGVARLHGARLN 427
Cdd:PRK13837 630 PFFTTRAG---GTGLGLATVHGIVSAHAGYID 658
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
146-441 |
5.72e-03 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 38.45 E-value: 5.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 146 VFLNILWISLLPTVLIALSGGLILARRSQRHVEVIRAALERITggnlgarvvtgkrwsddlvriggavntMADAQERsvt 225
Cdd:COG4585 5 ALLGALALLVGALLGLLLALVLLRARRAERAAELERELAARAE---------------------------EAREEER--- 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 226 alRQVSSDIaHDlkTPVQRVS---LQLEALQEVVKE---------TQASELVAQTRAEVEGIASVfqslLQLAQVENGAL 293
Cdd:COG4585 55 --RRIAREL-HD--GVGQSLSaikLQLEAARRLLDAdpeaareelEEIRELAREALAELRRLVRG----LRPPALDDLGL 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2769203217 294 QAAfapvdLAQLCLTMvdvyepsAQNAGQTISCDVAPDVQVMGE--KNLLGQMIANLLENALRHSGtGSKISLSLVCRAG 371
Cdd:COG4585 126 AAA-----LEELAERL-------LRAAGIRVELDVDGDPDRLPPevELALYRIVQEALTNALKHAG-ATRVTVTLEVDDG 192
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2769203217 372 TAELTVADTGPGIPEEErarvvqrlyrldrsrnTPGNGLGLSLVDGVARLHGARLNFG-DANPGLRVCVSF 441
Cdd:COG4585 193 ELTLTVRDDGVGFDPEA----------------APGGGLGLRGMRERAEALGGTLTIGsAPGGGTRVRATL 247
|
|
| |
