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Conserved domains on  [gi|2770159030|ref|WP_366547477|]
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BrnA antitoxin family protein [Salmonella enterica]

Protein Classification

BrnA antitoxin family protein( domain architecture ID 10007504)

BrnA antitoxin family protein similar to type II toxin-antitoxin system antitoxin BrnA that neutralizes the toxin BrnT

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3514 COG3514
Uncharacterized conserved protein, DUF4415 family [Function unknown];
11-83 1.42e-28

Uncharacterized conserved protein, DUF4415 family [Function unknown];


:

Pssm-ID: 442736  Cd Length: 91  Bit Score: 98.19  E-value: 1.42e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2770159030 11 TWINPDDAPELDDAFFSAAdlydgeKLVRRGRPKAINPKVRVTFRCSPEVVDAFRATGSGWQTRMNAALKDWL 83
Cdd:COG3514   24 AAIDPSDAPELTDEFFARA------RKRRRGRPKAAPPKVQVTIRLDPDVLEWFKATGPGWQTRINAALRDYL 90
 
Name Accession Description Interval E-value
COG3514 COG3514
Uncharacterized conserved protein, DUF4415 family [Function unknown];
11-83 1.42e-28

Uncharacterized conserved protein, DUF4415 family [Function unknown];


Pssm-ID: 442736  Cd Length: 91  Bit Score: 98.19  E-value: 1.42e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2770159030 11 TWINPDDAPELDDAFFSAAdlydgeKLVRRGRPKAINPKVRVTFRCSPEVVDAFRATGSGWQTRMNAALKDWL 83
Cdd:COG3514   24 AAIDPSDAPELTDEFFARA------RKRRRGRPKAAPPKVQVTIRLDPDVLEWFKATGPGWQTRINAALRDYL 90
BrnA_antitoxin pfam14384
BrnA antitoxin of type II toxin-antitoxin system; BrnA is family of antitoxins that ...
 17-83 1.43e-22

BrnA antitoxin of type II toxin-antitoxin system; BrnA is family of antitoxins that neutralizes the toxin BrnT, pfam04365. It consists of 3 alpha-helices and a C-terminal ribbon-helix-helix DNA binding domain. As in other toxin-antitoxin systems, BrnA negatively autoregulates the brnTA operon and has higher affinity for the DNA operator when complexed with BrnT. It dimerizes with two molecules of its toxin BrnT.


Pssm-ID: 433924  Cd Length: 67  Bit Score: 82.34  E-value: 1.43e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2770159030 17 DAPELDDA-FFSAADLYDGEKLVRRGRPkAINPKVRVTFRCSPEVVDAFRATGSGWQTRMNAALKDWL 83
Cdd:pfam14384  1 DAPELTDEqWLARARPAKEALPRGRPRR-PLPPKKAVTIRLDADVLEAFKATGKGWQTRMNAALREAL 67
 
Name Accession Description Interval E-value
COG3514 COG3514
Uncharacterized conserved protein, DUF4415 family [Function unknown];
11-83 1.42e-28

Uncharacterized conserved protein, DUF4415 family [Function unknown];


Pssm-ID: 442736  Cd Length: 91  Bit Score: 98.19  E-value: 1.42e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2770159030 11 TWINPDDAPELDDAFFSAAdlydgeKLVRRGRPKAINPKVRVTFRCSPEVVDAFRATGSGWQTRMNAALKDWL 83
Cdd:COG3514   24 AAIDPSDAPELTDEFFARA------RKRRRGRPKAAPPKVQVTIRLDPDVLEWFKATGPGWQTRINAALRDYL 90
BrnA_antitoxin pfam14384
BrnA antitoxin of type II toxin-antitoxin system; BrnA is family of antitoxins that ...
 17-83 1.43e-22

BrnA antitoxin of type II toxin-antitoxin system; BrnA is family of antitoxins that neutralizes the toxin BrnT, pfam04365. It consists of 3 alpha-helices and a C-terminal ribbon-helix-helix DNA binding domain. As in other toxin-antitoxin systems, BrnA negatively autoregulates the brnTA operon and has higher affinity for the DNA operator when complexed with BrnT. It dimerizes with two molecules of its toxin BrnT.


Pssm-ID: 433924  Cd Length: 67  Bit Score: 82.34  E-value: 1.43e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2770159030 17 DAPELDDA-FFSAADLYDGEKLVRRGRPkAINPKVRVTFRCSPEVVDAFRATGSGWQTRMNAALKDWL 83
Cdd:pfam14384  1 DAPELTDEqWLARARPAKEALPRGRPRR-PLPPKKAVTIRLDADVLEAFKATGKGWQTRMNAALREAL 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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