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Conserved domains on  [gi|2774295347|ref|WP_367374467|]
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SAM-dependent methyltransferase [Pseudomonas lini]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10616068)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to Homo sapiens methyltransferase-like protein 25B

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168|GO:0032259|GO:0008757
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Methyltransf_32 pfam13679
Methyltransferase domain; This family appears to be a methyltransferase domain.
 167-303 7.45e-34

Methyltransferase domain; This family appears to be a methyltransferase domain.


:

Pssm-ID: 379330 [Multi-domain]  Cd Length: 138  Bit Score: 123.06  E-value: 7.45e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774295347 167 RKWKQINKFIEvFSHALTSSPLALDKPVRVADFGSGKGYLTFAIHDylrntLKAEGEVTGVELREDMVNLCNTAAAKLE- 245
Cdd:pfam13679   1 KKLHQVEHLAE-FIAPLLKELLDENGPITIVDHGAGKGYLGFILYY-----LKYGVRVYGIDTRAELVEKANALAQKLGf 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2774295347 246 HPGLVFKCGDVRSVAPSEL----DVMIALHACDIATDYAIHTGIRSGASIIMCSPCCHKQIR 303
Cdd:pfam13679  75 NKRMSFLEGTIAGSTPVELpdrvDVVTALHACDTATDDALRFALAKQARAIVLVPCCYHELA 136
 
Name Accession Description Interval E-value
Methyltransf_32 pfam13679
Methyltransferase domain; This family appears to be a methyltransferase domain.
 167-303 7.45e-34

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 379330 [Multi-domain]  Cd Length: 138  Bit Score: 123.06  E-value: 7.45e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774295347 167 RKWKQINKFIEvFSHALTSSPLALDKPVRVADFGSGKGYLTFAIHDylrntLKAEGEVTGVELREDMVNLCNTAAAKLE- 245
Cdd:pfam13679   1 KKLHQVEHLAE-FIAPLLKELLDENGPITIVDHGAGKGYLGFILYY-----LKYGVRVYGIDTRAELVEKANALAQKLGf 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2774295347 246 HPGLVFKCGDVRSVAPSEL----DVMIALHACDIATDYAIHTGIRSGASIIMCSPCCHKQIR 303
Cdd:pfam13679  75 NKRMSFLEGTIAGSTPVELpdrvDVVTALHACDTATDDALRFALAKQARAIVLVPCCYHELA 136
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 189-271 4.88e-06

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 45.39  E-value: 4.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774295347 189 ALDKPVRVADFGSGKGYLTFAihdylrntLKAEG-EVTGVELREDMVNLcntAAAKLEHPGLVFKCGDVRSVAPSE--LD 265
Cdd:COG2227    21 LLPAGGRVLDVGCGTGRLALA--------LARRGaDVTGVDISPEALEI---ARERAAELNVDFVQGDLEDLPLEDgsFD 89


                  ....*.
gi 2774295347 266 VMIALH 271
Cdd:COG2227    90 LVICSE 95
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 195-273 3.98e-05

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 42.42  E-value: 3.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774295347 195 RVADFGSGKGYLTFAIHDYLrntlkaEGEVTGVELREDMVNLCNTAAAKLEHPGLVFKCGDVRSV---APSELDVMIALH 271
Cdd:cd02440     1 RVLDLGCGTGALALALASGP------GARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELppeADESFDVIISDP 74


                  ..
gi 2774295347 272 AC 273
Cdd:cd02440    75 PL 76
 
Name Accession Description Interval E-value
Methyltransf_32 pfam13679
Methyltransferase domain; This family appears to be a methyltransferase domain.
 167-303 7.45e-34

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 379330 [Multi-domain]  Cd Length: 138  Bit Score: 123.06  E-value: 7.45e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774295347 167 RKWKQINKFIEvFSHALTSSPLALDKPVRVADFGSGKGYLTFAIHDylrntLKAEGEVTGVELREDMVNLCNTAAAKLE- 245
Cdd:pfam13679   1 KKLHQVEHLAE-FIAPLLKELLDENGPITIVDHGAGKGYLGFILYY-----LKYGVRVYGIDTRAELVEKANALAQKLGf 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2774295347 246 HPGLVFKCGDVRSVAPSEL----DVMIALHACDIATDYAIHTGIRSGASIIMCSPCCHKQIR 303
Cdd:pfam13679  75 NKRMSFLEGTIAGSTPVELpdrvDVVTALHACDTATDDALRFALAKQARAIVLVPCCYHELA 136
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 190-326 2.75e-06

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 46.64  E-value: 2.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774295347 190 LDKPVRVADFGSGKGYLTFAIHDYLRntlkAEGEVTGVELREDMVNLCNTAAAKLEHPGLVFKCGDV----RSVAPSELD 265
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEELG----PNAEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIeelpELLEDDKFD 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2774295347 266 VMIALHACDIATDYA-----IHTGIRSGASIIMCSPCCHKQIRLQIQSPALLKPMLQYGLHLGQQA 326
Cdd:pfam13847  77 VVISNCVLNHIPDPDkvlqeILRVLKPGGRLIISDPDSLAELPAHVKEDSTYYAGCVGGAILKKKL 142
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 189-271 4.88e-06

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 45.39  E-value: 4.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774295347 189 ALDKPVRVADFGSGKGYLTFAihdylrntLKAEG-EVTGVELREDMVNLcntAAAKLEHPGLVFKCGDVRSVAPSE--LD 265
Cdd:COG2227    21 LLPAGGRVLDVGCGTGRLALA--------LARRGaDVTGVDISPEALEI---ARERAAELNVDFVQGDLEDLPLEDgsFD 89


                  ....*.
gi 2774295347 266 VMIALH 271
Cdd:COG2227    90 LVICSE 95
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
192-271 6.74e-06

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 44.43  E-value: 6.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774295347 192 KPVRVADFGSGKGYLTFAIHDYLRNtlkaeGEVTGVELREDMVnlcntAAAKLEHPGLVFKCGDVRSVAPSE-LDVMI-- 268
Cdd:COG4106     1 PPRRVLDLGCGTGRLTALLAERFPG-----ARVTGVDLSPEML-----ARARARLPNVRFVVADLRDLDPPEpFDLVVsn 70


                  ....
gi 2774295347 269 -ALH 271
Cdd:COG4106    71 aALH 74
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 188-272 3.51e-05

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 43.44  E-value: 3.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774295347 188 LALDKPVRVADFGSGKGYLTFAIhdylrntLKAEGEVTGVELREDMVNLCNTAAAKlEHPGLVFKCGDVRS--VAPSELD 265
Cdd:COG2226    18 LGLRPGARVLDLGCGTGRLALAL-------AERGARVTGVDISPEMLELARERAAE-AGLNVEFVVGDAEDlpFPDGSFD 89


                  ....*..
gi 2774295347 266 VMIALHA 272
Cdd:COG2226    90 LVISSFV 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 195-273 3.98e-05

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 42.42  E-value: 3.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774295347 195 RVADFGSGKGYLTFAIHDYLrntlkaEGEVTGVELREDMVNLCNTAAAKLEHPGLVFKCGDVRSV---APSELDVMIALH 271
Cdd:cd02440     1 RVLDLGCGTGALALALASGP------GARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELppeADESFDVIISDP 74


                  ..
gi 2774295347 272 AC 273
Cdd:cd02440    75 PL 76
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 190-341 6.59e-05

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 43.75  E-value: 6.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774295347 190 LDKPVRVADFGSGKGYLTFAIHDYLRntlkaeGEVTGVELREDMVNLCNTAAAKLEHPGLVFKCGDVRSVAPSEL---DV 266
Cdd:COG0500    24 LPKGGRVLDLGCGTGRNLLALAARFG------GRVIGIDLSPEAIALARARAAKAGLGNVEFLVADLAELDPLPAesfDL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774295347 267 MIA---LHACDIATDYAIHTGIRS----GASIIMcspcchkqirlqiqSPALLKPMLQYGLHLGQQAEMVTDSLRALFLE 339
Cdd:COG0500    98 VVAfgvLHHLPPEEREALLRELARalkpGGVLLL--------------SASDAAAALSLARLLLLATASLLELLLLLRLL 163


                  ..
gi 2774295347 340 AC 341
Cdd:COG0500   164 AL 165
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 196-258 1.69e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 40.24  E-value: 1.69e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2774295347 196 VADFGSGKGYLTFAIHDYLrntlkaEGEVTGVELREDMVNLCNTAAAKlEHPGLVFKCGDVRS 258
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRG------GARVTGVDLSPEMLERARERAAE-AGLNVEFVQGDAED 56
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 195-267 4.12e-04

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 41.68  E-value: 4.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774295347 195 RVADFGSGKGYLTFaihdYLRNTLKAEGEVTGVELREDMVNLC--NTAAAKLeHPGLVFKCGDVRSVAPSE------LDV 266
Cdd:COG2519    94 RVLEAGTGSGALTL----ALARAVGPEGKVYSYERREDFAEIArkNLERFGL-PDNVELKLGDIREGIDEGdvdavfLDM 168


                  .
gi 2774295347 267 M 267
Cdd:COG2519   169 P 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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