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Conserved domains on  [gi|2774296510|ref|WP_367375630|]
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N-acetyltransferase family protein [Pseudomonas lini]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 11441181)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
1-171 4.90e-22

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


:

Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 86.97  E-value: 4.90e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774296510   1 MINIREATKADLDVLREVgcktYREHfsaiwSLAGMQDFLNRDFSPRALGQSLES--SASHLWLIAsDESGRVVGFCKVN 78
Cdd:COG1247     1 EMTIRPATPEDAPAIAAI----YNEA-----IAEGTATFETEPPSEEEREAWFAAilAPGRPVLVA-EEDGEVVGFASLG 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774296510  79 WSAPAPLTGEVgAELQkIYFLKSEAGRGYGKQLLRFICNRAIERGERLLWLDVLKTNSNARRFYEGFGFQKIGEIP--FK 156
Cdd:COG1247    71 PFRPRPAYRGT-AEES-IYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEVGTLPevGF 148

                         170
                  ....*....|....*
gi 2774296510 157 TDLAEIGMVVMACEL 171
Cdd:COG1247   149 KFGRWLDLVLMQKRL 163
 
Name Accession Description Interval E-value
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
1-171 4.90e-22

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 86.97  E-value: 4.90e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774296510   1 MINIREATKADLDVLREVgcktYREHfsaiwSLAGMQDFLNRDFSPRALGQSLES--SASHLWLIAsDESGRVVGFCKVN 78
Cdd:COG1247     1 EMTIRPATPEDAPAIAAI----YNEA-----IAEGTATFETEPPSEEEREAWFAAilAPGRPVLVA-EEDGEVVGFASLG 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774296510  79 WSAPAPLTGEVgAELQkIYFLKSEAGRGYGKQLLRFICNRAIERGERLLWLDVLKTNSNARRFYEGFGFQKIGEIP--FK 156
Cdd:COG1247    71 PFRPRPAYRGT-AEES-IYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEVGTLPevGF 148

                         170
                  ....*....|....*
gi 2774296510 157 TDLAEIGMVVMACEL 171
Cdd:COG1247   149 KFGRWLDLVLMQKRL 163
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 45-147 1.00e-12

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 61.38  E-value: 1.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774296510  45 SPRALGQSLESSASHLWLIASDesGRVVGFCKVNWSAPAPLTGEVGAelqkIYFLKSEAGRGYGKQLLRFICNRAIERGE 124
Cdd:pfam00583  20 PLDLLEDWDEDASEGFFVAEED--GELVGFASLSIIDDEPPVGEIEG----LAVAPEYRGKGIGTALLQALLEWARERGC 93

                          90       100
                  ....*....|....*....|...
gi 2774296510 125 RLLWLDVLKTNSNARRFYEGFGF 147
Cdd:pfam00583  94 ERIFLEVAADNLAAIALYEKLGF 116
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 59-154 5.97e-11

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 56.95  E-value: 5.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774296510  59 HLWLIASDESGRVVGFCKVNwsapaplTGEVGAELQKIYFLKSEAGRGYGKQLLRFICNRAIERGERLLWLDVLKTNSNA 138
Cdd:TIGR01575  30 HLCYLLARIGGKVVGYAGVQ-------IVLDEAHILNIAVKPEYQGQGIGRALLRELIDEAKGRGVNEIFLEVRVSNIAA 102

                          90
                  ....*....|....*.
gi 2774296510 139 RRFYEGFGFQKIGEIP 154
Cdd:TIGR01575 103 QALYKKLGFNEIAIRR 118
rimI PRK09491
ribosomal-protein-alanine N-acetyltransferase; Provisional
 104-147 3.23e-07

ribosomal-protein-alanine N-acetyltransferase; Provisional


Pssm-ID: 181904 [Multi-domain]  Cd Length: 146  Bit Score: 47.23  E-value: 3.23e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2774296510 104 GRGYGKQLLRFICNRAIERGERLLWLDVLKTNSNARRFYEGFGF 147
Cdd:PRK09491   77 RQGLGRALLEHLIDELEKRGVATLWLEVRASNAAAIALYESLGF 120
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 61-130 4.71e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 42.26  E-value: 4.71e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774296510  61 WLIASDEsGRVVGFCKVNWSAPAPLTGEVGAelqkIYFLKSEAGRGYGKQLLRFICNRAIERGERLLWLD 130
Cdd:cd04301     1 FLVAEDD-GEIVGFASLSPDGSGGDTAYIGD----LAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
Spm_actase_Thplmales NF041158
spermidine N(1)-acetyltransferase;
1-112 6.87e-03

spermidine N(1)-acetyltransferase;


Pssm-ID: 469070  Cd Length: 115  Bit Score: 34.90  E-value: 6.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774296510   1 MINIREATKADLDVLREVGCKTYREHFSAIWSLAGMQDFLNRDFSPRALGQSLESSASHLWLI--ASDESGRVVGFCKVN 78
Cdd:NF041158    1 MITIRKLSAEDVDALIEVARESWKWTYRDIYSNEFIESWISEKYSKEKLLNEIIRSQSNLDIIflGAFVNSALIGFIELK 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2774296510  79 WSAPApltgevgAELQKIYFLKSEAGRGYGKQLL 112
Cdd:NF041158   81 IIADK-------AELLRLYLKPEYTHRGIGKLLL 107
 
Name Accession Description Interval E-value
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
1-171 4.90e-22

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 86.97  E-value: 4.90e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774296510   1 MINIREATKADLDVLREVgcktYREHfsaiwSLAGMQDFLNRDFSPRALGQSLES--SASHLWLIAsDESGRVVGFCKVN 78
Cdd:COG1247     1 EMTIRPATPEDAPAIAAI----YNEA-----IAEGTATFETEPPSEEEREAWFAAilAPGRPVLVA-EEDGEVVGFASLG 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774296510  79 WSAPAPLTGEVgAELQkIYFLKSEAGRGYGKQLLRFICNRAIERGERLLWLDVLKTNSNARRFYEGFGFQKIGEIP--FK 156
Cdd:COG1247    71 PFRPRPAYRGT-AEES-IYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEVGTLPevGF 148

                         170
                  ....*....|....*
gi 2774296510 157 TDLAEIGMVVMACEL 171
Cdd:COG1247   149 KFGRWLDLVLMQKRL 163
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 91-172 8.88e-17

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 71.23  E-value: 8.88e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774296510  91 AELQKIYFLKSEAGRGYGKQLLRFICNRAIERGERLLWLDVLKTNSNARRFYEGFGFQKIGEIPfktDLAEIGMVVMACE 170
Cdd:COG0456    14 AEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGERP---NYYGDDALVMEKE 90


                  ..
gi 2774296510 171 LS 172
Cdd:COG0456    91 LA 92
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 62-157 1.69e-14

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 66.62  E-value: 1.69e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774296510  62 LIASDESGRVVGFCKVNwsapapLTGEVGAELQKIYFLKSEAGRGYGKQLLRFICNRAIERGERLLWLDVLKTNSNARRF 141
Cdd:COG0454    36 FIAVDDKGEPIGFAGLR------RLDDKVLELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTLDGNPAAIRF 109

                          90
                  ....*....|....*.
gi 2774296510 142 YEGFGFQKIGEIPFKT 157
Cdd:COG0454   110 YERLGFKEIERYVAYV 125
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 1-154 2.10e-14

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 66.95  E-value: 2.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774296510   1 MINIREATKADLDVLREVGC--KTYREHFSAIWSLAGMQDFLNRDFSPRALGQSLessashLWLIASDESGRVVGFCKVN 78
Cdd:COG1670     7 RLRLRPLRPEDAEALAELLNdpEVARYLPGPPYSLEEARAWLERLLADWADGGAL------PFAIEDKEDGELIGVVGLY 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2774296510  79 WSAPAPLTGEVGaelqkIYFLKSEAGRGYGKQLLRFICNRAIER-GERLLWLDVLKTNSNARRFYEGFGFQKIGEIP 154
Cdd:COG1670    81 DIDRANRSAEIG-----YWLAPAYWGKGYATEALRALLDYAFEElGLHRVEAEVDPDNTASIRVLEKLGFRLEGTLR 152
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
4-171 3.79e-14

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 65.88  E-value: 3.79e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774296510   4 IREATKADLDVLREVGCKTYREHFSAiwslagmqdflnrdfspRALGQSLESSASHLWLIASDEsGRVVGFCKVnwsAPA 83
Cdd:COG3153     1 IRPATPEDAEAIAALLRAAFGPGREA-----------------ELVDRLREDPAAGLSLVAEDD-GEIVGHVAL---SPV 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774296510  84 PLTGEVG-AELQKIYFLKSEAGRGYGKQLLRFICNRAIERGERLLWLDvlkTNSNARRFYEGFGFQKIGEIPFKTDLAEi 162
Cdd:COG3153    60 DIDGEGPaLLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLL---GDPSLLPFYERFGFRPAGELGLTLGPDE- 135


                  ....*....
gi 2774296510 163 gmVVMACEL 171
Cdd:COG3153   136 --VFLAKEL 142
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 2-152 1.00e-13

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 64.24  E-value: 1.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774296510   2 INIREATKADLDVLREvgcktyrehfsaiwslagmqdfLNRDFSpralgqsLESSASHLWLIasDESGRVVGFCKVnwsa 81
Cdd:COG1246     1 MTIRPATPDDVPAILE----------------------LIRPYA-------LEEEIGEFWVA--EEDGEIVGCAAL---- 45

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2774296510  82 pAPLTGEVgAELQKIYFLKSEAGRGYGKQLLRFICNRAIERGERLLWLDvlkTNSNARRFYEGFGFQKIGE 152
Cdd:COG1246    46 -HPLDEDL-AELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLL---TTSAAIHFYEKLGFEEIDK 111
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
70-155 1.75e-13

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 62.62  E-value: 1.75e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774296510  70 RVVGFCKVNWSAPApltgevGAELQKIYFLKSEAGRGYGKQLLRFICNRAIERGERLLWLDVLKTNSNARRFYEGFGFQK 149
Cdd:COG3393     1 ELVAMAGVRAESPG------VAEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLYVDADNPAARRLYERLGFRP 74


                  ....*.
gi 2774296510 150 IGEIPF 155
Cdd:COG3393    75 VGEYAT 80
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 45-147 1.00e-12

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 61.38  E-value: 1.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774296510  45 SPRALGQSLESSASHLWLIASDesGRVVGFCKVNWSAPAPLTGEVGAelqkIYFLKSEAGRGYGKQLLRFICNRAIERGE 124
Cdd:pfam00583  20 PLDLLEDWDEDASEGFFVAEED--GELVGFASLSIIDDEPPVGEIEG----LAVAPEYRGKGIGTALLQALLEWARERGC 93

                          90       100
                  ....*....|....*....|...
gi 2774296510 125 RLLWLDVLKTNSNARRFYEGFGF 147
Cdd:pfam00583  94 ERIFLEVAADNLAAIALYEKLGF 116
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 59-154 5.97e-11

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 56.95  E-value: 5.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774296510  59 HLWLIASDESGRVVGFCKVNwsapaplTGEVGAELQKIYFLKSEAGRGYGKQLLRFICNRAIERGERLLWLDVLKTNSNA 138
Cdd:TIGR01575  30 HLCYLLARIGGKVVGYAGVQ-------IVLDEAHILNIAVKPEYQGQGIGRALLRELIDEAKGRGVNEIFLEVRVSNIAA 102

                          90
                  ....*....|....*.
gi 2774296510 139 RRFYEGFGFQKIGEIP 154
Cdd:TIGR01575 103 QALYKKLGFNEIAIRR 118
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 58-149 1.18e-09

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 52.46  E-value: 1.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774296510  58 SHLWLIASDesGRVVGFCKVnwsapAPLTGEVGAELQKIYFLKSEAGRGYGKQLLRFICNRAIERGERLLWLDvlkTNSN 137
Cdd:pfam13508   3 GRFFVAEDD--GKIVGFAAL-----LPLDDEGALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELE---TTNR 72

                          90
                  ....*....|..
gi 2774296510 138 ARRFYEGFGFQK 149
Cdd:pfam13508  73 AAAFYEKLGFEE 84
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
53-172 2.36e-09

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 52.88  E-value: 2.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774296510  53 LESSASHLWLIasdESGRVVGFCKVNWSAPApltgevGAELQKIYFLKSEAGRGYGKQLLRFICNRAIERGERLLWLDVL 132
Cdd:COG2153    30 KDEDARHLLAY---DDGELVATARLLPPGDG------EAKIGRVAVLPEYRGQGLGRALMEAAIEEARERGARRIVLSAQ 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2774296510 133 KTnsnARRFYEGFGFQKIGEiPFktDLAEIGMVVMACELS 172
Cdd:COG2153   101 AH---AVGFYEKLGFVPVGE-EF--LEAGIPHIDMRKPLS 134
rimI PRK09491
ribosomal-protein-alanine N-acetyltransferase; Provisional
 104-147 3.23e-07

ribosomal-protein-alanine N-acetyltransferase; Provisional


Pssm-ID: 181904 [Multi-domain]  Cd Length: 146  Bit Score: 47.23  E-value: 3.23e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2774296510 104 GRGYGKQLLRFICNRAIERGERLLWLDVLKTNSNARRFYEGFGF 147
Cdd:PRK09491   77 RQGLGRALLEHLIDELEKRGVATLWLEVRASNAAAIALYESLGF 120
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 35-152 4.31e-06

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 43.80  E-value: 4.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774296510  35 GMQDFLNRdFSPRALGQSLESSASHLWliASDESGRVVGFCKVnwsapapltgevgAELQKIYFL---KSEAGRGYGKQL 111
Cdd:pfam13673   9 GIETFYEF-ISPEALRERIDQGEYFFF--VAFEGGQIVGVIAL-------------RDRGHISLLfvdPDYQGQGIGKAL 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2774296510 112 LRFICNRAIERGERLLWLDVlktNS--NARRFYEGFGFQKIGE 152
Cdd:pfam13673  73 LEAVEDYAEKDGIKLSELTV---NAspYAVPFYEKLGFRATGP 112
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 61-130 4.71e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 42.26  E-value: 4.71e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774296510  61 WLIASDEsGRVVGFCKVNWSAPAPLTGEVGAelqkIYFLKSEAGRGYGKQLLRFICNRAIERGERLLWLD 130
Cdd:cd04301     1 FLVAEDD-GEIVGFASLSPDGSGGDTAYIGD----LAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
 90-150 3.08e-05

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 40.78  E-value: 3.08e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2774296510  90 GAELQKIYFLKSEAGRGYGKQLLRFICNRAIERGERLLwLDVLKTNSNARRFYEGFGFQKI 150
Cdd:pfam08445  21 GGELGALQTLPEHRRRGLGSRLVAALARGIAERGITPF-AVVVAGNTPSRRLYEKLGFRKI 80
PRK10514 PRK10514
putative acetyltransferase; Provisional
 1-151 3.70e-03

putative acetyltransferase; Provisional


Pssm-ID: 182510 [Multi-domain]  Cd Length: 145  Bit Score: 36.13  E-value: 3.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774296510   1 MINIREATKADLDVLREvgcktyrehfsaIW--SLAGMQDFLNRDFSpRALGQSLESSASH--LWLiASDESGRVVGFCK 76
Cdd:PRK10514    1 MISIRRSRHEEGERLVA------------IWrrSVDATHDFLSAEDR-AEIEELVRSFLPEapLWV-AVDERDQPVGFML 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2774296510  77 VNwsapapltgevGAELQKIYFLKSEAGRGYGKQLLRFICNRAIErgerlLWLDVLKTNSNARRFYEGFGFQKIG 151
Cdd:PRK10514   67 LS-----------GGHMEALFVDPDVRGCGVGRMLVEHALSLHPE-----LTTDVNEQNEQAVGFYKKMGFKVTG 125
Spm_actase_Thplmales NF041158
spermidine N(1)-acetyltransferase;
1-112 6.87e-03

spermidine N(1)-acetyltransferase;


Pssm-ID: 469070  Cd Length: 115  Bit Score: 34.90  E-value: 6.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2774296510   1 MINIREATKADLDVLREVGCKTYREHFSAIWSLAGMQDFLNRDFSPRALGQSLESSASHLWLI--ASDESGRVVGFCKVN 78
Cdd:NF041158    1 MITIRKLSAEDVDALIEVARESWKWTYRDIYSNEFIESWISEKYSKEKLLNEIIRSQSNLDIIflGAFVNSALIGFIELK 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2774296510  79 WSAPApltgevgAELQKIYFLKSEAGRGYGKQLL 112
Cdd:NF041158   81 IIADK-------AELLRLYLKPEYTHRGIGKLLL 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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