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Conserved domains on  [gi|2775742966|ref|WP_367656805|]
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NlpC/P60 family protein, partial [Terrisporobacter glycolicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
43-189 9.51e-60

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 185.67  E-value: 9.51e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775742966  43 SSDYISKGGESSGGSEGSGGGSSETNNAQAIINIAKAQLGKPYVWGAEGPNSFDCSGLVYYVYGQHGIKMPRTSREQANV 122
Cdd:COG0791    73 AAAAAAAKAGSSAAKSAAGASAPPSSTAEAIVAAALSYLGTPYVWGGTSPSGFDCSGLVQYVYRQAGISLPRTSADQAAA 152

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2775742966 123 GTTVSQSQLQPGDLIFSSTDGsGGVNHVGIYIGNGQMIHAPKPGDVVKTTNINSSYWQNTYVKAKRV 189
Cdd:COG0791   153 GTPVSRSELQPGDLVFFRTGG-GGISHVGIYLGNGKFIHASSSGKGVRISSLDSPYWKSRYVGARRV 218
YgiM COG3103
Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family ...
 1-49 5.32e-14

Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family [General function prediction only];


:

Pssm-ID: 442337 [Multi-domain]  Cd Length: 119  Bit Score: 65.14  E-value: 5.32e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2775742966   1 RSGPSTSNSIVGKAYKGNTVDILSSSNGWYKVKLSNGQVGWGSSDYISK 49
Cdd:COG3103    17 RSGPGTSYRIVGTLPKGEKVTVLGRSGGWYKVRYSNGKTGWVSSRYLTV 65
 
Name Accession Description Interval E-value
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
43-189 9.51e-60

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 185.67  E-value: 9.51e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775742966  43 SSDYISKGGESSGGSEGSGGGSSETNNAQAIINIAKAQLGKPYVWGAEGPNSFDCSGLVYYVYGQHGIKMPRTSREQANV 122
Cdd:COG0791    73 AAAAAAAKAGSSAAKSAAGASAPPSSTAEAIVAAALSYLGTPYVWGGTSPSGFDCSGLVQYVYRQAGISLPRTSADQAAA 152

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2775742966 123 GTTVSQSQLQPGDLIFSSTDGsGGVNHVGIYIGNGQMIHAPKPGDVVKTTNINSSYWQNTYVKAKRV 189
Cdd:COG0791   153 GTPVSRSELQPGDLVFFRTGG-GGISHVGIYLGNGKFIHASSSGKGVRISSLDSPYWKSRYVGARRV 218
NLPC_P60 pfam00877
NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.
 82-188 3.78e-41

NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.


Pssm-ID: 395705 [Multi-domain]  Cd Length: 105  Bit Score: 134.72  E-value: 3.78e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775742966  82 GKPYVWGAEGPNSFDCSGLVYYVYGQHGIKMPRTSREQANVGT-TVSQSQLQPGDLIFssTDGSGGVNHVGIYIGNGQMI 160
Cdd:pfam00877   1 GVPYRWGGGSPSGFDCSGLVRYAFAKVGIELPRSSGQQYNAGKkTIPKSEPQRGDLVF--FGTGKGISHVGIYLGNGQML 78

                          90       100
                  ....*....|....*....|....*...
gi 2775742966 161 HAPkPGDVVKTTNINSSYWQNTYVKAKR 188
Cdd:pfam00877  79 HAS-TGGGVSISSLNGGYWQKRLVGVRR 105
PRK13914 PRK13914
invasion associated endopeptidase;
67-189 5.99e-32

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 119.91  E-value: 5.99e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775742966  67 TNNAQAIINIAKAQLGKPYVWGAEGPNSFDCSGLVYYVYGQHGIKMPRTSREQANVGTTVSQSQLQPGDLIFssTDGSGG 146
Cdd:PRK13914  363 NSSASAIIAEAQKHLGKAYSWGGNGPTTFDCSGYTKYVFAKAGISLPRTSGAQYASTTRISESQAKPGDLVF--FDYGSG 440

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2775742966 147 VNHVGIYIGNGQMIHAPKPGdvVKTTNINSSYWQNTYVKAKRV 189
Cdd:PRK13914  441 ISHVGIYVGNGQMINAQDNG--VKYDNIHGSGWGKYLVGFGRV 481
YgiM COG3103
Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family ...
 1-49 5.32e-14

Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family [General function prediction only];


Pssm-ID: 442337 [Multi-domain]  Cd Length: 119  Bit Score: 65.14  E-value: 5.32e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2775742966   1 RSGPSTSNSIVGKAYKGNTVDILSSSNGWYKVKLSNGQVGWGSSDYISK 49
Cdd:COG3103    17 RSGPGTSYRIVGTLPKGEKVTVLGRSGGWYKVRYSNGKTGWVSSRYLTV 65
SH3_3 pfam08239
Bacterial SH3 domain;
1-48 1.05e-11

Bacterial SH3 domain;


Pssm-ID: 462405 [Multi-domain]  Cd Length: 54  Bit Score: 57.26  E-value: 1.05e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2775742966   1 RSGPSTSNSIVGKAYKGNTVDILSSSNG-WYKVKLSNGQVGWGSSDYIS 48
Cdd:pfam08239   6 RSGPSTSSEVVGTLPKGEKVEVLEEQGGgWYKVRTYDGYEGWVSSSYLS 54
SH3b smart00287
Bacterial SH3 domain homologues;
1-41 2.80e-06

Bacterial SH3 domain homologues;


Pssm-ID: 214600 [Multi-domain]  Cd Length: 63  Bit Score: 43.09  E-value: 2.80e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2775742966    1 RSGPSTSNSIVGKAYKGNTVDILSSSN-GWYKVKLSNGQVGW 41
Cdd:smart00287  14 RTGPGTSSPIIGTLKKGDKVKVLGVDGqDWAKITYGSGQRGY 55
SH3_and_anchor TIGR04211
SH3 domain protein; Members of this protein family have a signal peptide, a strongly conserved ...
 1-48 1.15e-05

SH3 domain protein; Members of this protein family have a signal peptide, a strongly conserved SH3 domain, a variable region, and then a C-terminal hydrophobic transmembrane alpha helix region.


Pssm-ID: 275056 [Multi-domain]  Cd Length: 198  Bit Score: 43.84  E-value: 1.15e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2775742966   1 RSGPSTSNSIVGKAYKGNTVDILS-SSNGWYKVKLSNGQVGWGSSDYIS 48
Cdd:TIGR04211  11 RSGPGNQYRILGSLKSGTPVTVLErSEDGYSRVRTPKGREGWVLSRYLS 59
SH3_Nck_2 cd11766
Second Src Homology 3 domain of Nck adaptor proteins; Nck adaptor proteins regulate actin ...
 16-49 4.32e-03

Second Src Homology 3 domain of Nck adaptor proteins; Nck adaptor proteins regulate actin cytoskeleton dynamics by linking proline-rich effector molecules to protein tyrosine kinases and phosphorylated signaling intermediates. They contain three SH3 domains and a C-terminal SH2 domain. They function downstream of the PDGFbeta receptor and are involved in Rho GTPase signaling and actin dynamics. Vertebrates contain two Nck adaptor proteins: Nck1 (also called Nckalpha) and Nck2 (also called Nckbeta or Growth factor receptor-bound protein 4, Grb4), which show partly overlapping functions but also bind distinct targets. Their SH3 domains are involved in recruiting downstream effector molecules, such as the N-WASP/Arp2/3 complex, which when activated induces actin polymerization that results in the production of pedestals, or protrusions of the plasma membrane. The second SH3 domain of Nck appears to prefer ligands containing the APxxPxR motif. SH3 domains are protein interaction domains that usually bind to proline-rich ligands with moderate affinity and selectivity, preferentially a PxxP motif. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.


Pssm-ID: 212700 [Multi-domain]  Cd Length: 53  Bit Score: 34.16  E-value: 4.32e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2775742966  16 KGNTVDIL-SSSNGWYKVKLsNGQVGWGSSDYISK 49
Cdd:cd11766    20 KGDRVLVLeKSSDGWWRGEC-NGQVGWFPSNYVTE 53
 
Name Accession Description Interval E-value
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
43-189 9.51e-60

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 185.67  E-value: 9.51e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775742966  43 SSDYISKGGESSGGSEGSGGGSSETNNAQAIINIAKAQLGKPYVWGAEGPNSFDCSGLVYYVYGQHGIKMPRTSREQANV 122
Cdd:COG0791    73 AAAAAAAKAGSSAAKSAAGASAPPSSTAEAIVAAALSYLGTPYVWGGTSPSGFDCSGLVQYVYRQAGISLPRTSADQAAA 152

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2775742966 123 GTTVSQSQLQPGDLIFSSTDGsGGVNHVGIYIGNGQMIHAPKPGDVVKTTNINSSYWQNTYVKAKRV 189
Cdd:COG0791   153 GTPVSRSELQPGDLVFFRTGG-GGISHVGIYLGNGKFIHASSSGKGVRISSLDSPYWKSRYVGARRV 218
NLPC_P60 pfam00877
NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.
 82-188 3.78e-41

NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.


Pssm-ID: 395705 [Multi-domain]  Cd Length: 105  Bit Score: 134.72  E-value: 3.78e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775742966  82 GKPYVWGAEGPNSFDCSGLVYYVYGQHGIKMPRTSREQANVGT-TVSQSQLQPGDLIFssTDGSGGVNHVGIYIGNGQMI 160
Cdd:pfam00877   1 GVPYRWGGGSPSGFDCSGLVRYAFAKVGIELPRSSGQQYNAGKkTIPKSEPQRGDLVF--FGTGKGISHVGIYLGNGQML 78

                          90       100
                  ....*....|....*....|....*...
gi 2775742966 161 HAPkPGDVVKTTNINSSYWQNTYVKAKR 188
Cdd:pfam00877  79 HAS-TGGGVSISSLNGGYWQKRLVGVRR 105
PRK13914 PRK13914
invasion associated endopeptidase;
67-189 5.99e-32

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 119.91  E-value: 5.99e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775742966  67 TNNAQAIINIAKAQLGKPYVWGAEGPNSFDCSGLVYYVYGQHGIKMPRTSREQANVGTTVSQSQLQPGDLIFssTDGSGG 146
Cdd:PRK13914  363 NSSASAIIAEAQKHLGKAYSWGGNGPTTFDCSGYTKYVFAKAGISLPRTSGAQYASTTRISESQAKPGDLVF--FDYGSG 440

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2775742966 147 VNHVGIYIGNGQMIHAPKPGdvVKTTNINSSYWQNTYVKAKRV 189
Cdd:PRK13914  441 ISHVGIYVGNGQMINAQDNG--VKYDNIHGSGWGKYLVGFGRV 481
spr PRK10838
bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase;
82-190 9.47e-22

bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase;


Pssm-ID: 236773 [Multi-domain]  Cd Length: 190  Bit Score: 87.51  E-value: 9.47e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775742966  82 GKPYVWGAEGPNSFDCSGLVYYVY-GQHGIKMPRTSREQANVGTTVSQSQLQPGDLIFSSTdGSGGvNHVGIYIGNGQMI 160
Cdd:PRK10838   79 GVRYRLGGSTKKGIDCSAFVQRTFrEQFGLELPRSTYEQQEMGKSVSRSKLRTGDLVLFRA-GSTG-RHVGIYIGNNQFV 156

                          90       100       110
                  ....*....|....*....|....*....|
gi 2775742966 161 HAPKPGDVVkTTNINSSYWQNTYVKAKRVL 190
Cdd:PRK10838  157 HASTSSGVI-ISSMNEPYWKKRYNEARRVL 185
YgiM COG3103
Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family ...
 1-49 5.32e-14

Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family [General function prediction only];


Pssm-ID: 442337 [Multi-domain]  Cd Length: 119  Bit Score: 65.14  E-value: 5.32e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2775742966   1 RSGPSTSNSIVGKAYKGNTVDILSSSNGWYKVKLSNGQVGWGSSDYISK 49
Cdd:COG3103    17 RSGPGTSYRIVGTLPKGEKVTVLGRSGGWYKVRYSNGKTGWVSSRYLTV 65
SH3_3 pfam08239
Bacterial SH3 domain;
1-48 1.05e-11

Bacterial SH3 domain;


Pssm-ID: 462405 [Multi-domain]  Cd Length: 54  Bit Score: 57.26  E-value: 1.05e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2775742966   1 RSGPSTSNSIVGKAYKGNTVDILSSSNG-WYKVKLSNGQVGWGSSDYIS 48
Cdd:pfam08239   6 RSGPSTSSEVVGTLPKGEKVEVLEEQGGgWYKVRTYDGYEGWVSSSYLS 54
YraI COG4991
Uncharacterized conserved protein YraI [Function unknown];
1-49 3.15e-08

Uncharacterized conserved protein YraI [Function unknown];


Pssm-ID: 444015 [Multi-domain]  Cd Length: 92  Bit Score: 49.29  E-value: 3.15e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2775742966   1 RSGPSTSNSIVGKAYKGNTVDILS--SSNGWYKVKLsNGQVGWGSSDYISK 49
Cdd:COG4991    34 RSGPGTGYPVVGTLPAGATVTVLGctSGGGWCKVSY-GGQRGWVSARYLQV 83
YycO COG3863
Uncharacterized conserved protein YycO, NlpC/P60 family [Function unknown];
129-189 7.80e-07

Uncharacterized conserved protein YycO, NlpC/P60 family [Function unknown];


Pssm-ID: 443072  Cd Length: 166  Bit Score: 46.91  E-value: 7.80e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2775742966 129 SQLQPGDLIF--SSTDGSGGVNHVGIYIGNGQMIHAPKPGdvVKTTNINSsyWQNTYVKAKRV 189
Cdd:COG3863    26 APLQPGDILLtkSPSTLSGNHGHAGIYIGDGQVVEAVGDG--VRIIPLET--WLDRYDTVAVL 84
SH3b smart00287
Bacterial SH3 domain homologues;
1-41 2.80e-06

Bacterial SH3 domain homologues;


Pssm-ID: 214600 [Multi-domain]  Cd Length: 63  Bit Score: 43.09  E-value: 2.80e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2775742966    1 RSGPSTSNSIVGKAYKGNTVDILSSSN-GWYKVKLSNGQVGW 41
Cdd:smart00287  14 RTGPGTSSPIIGTLKKGDKVKVLGVDGqDWAKITYGSGQRGY 55
SH3_and_anchor TIGR04211
SH3 domain protein; Members of this protein family have a signal peptide, a strongly conserved ...
 1-48 1.15e-05

SH3 domain protein; Members of this protein family have a signal peptide, a strongly conserved SH3 domain, a variable region, and then a C-terminal hydrophobic transmembrane alpha helix region.


Pssm-ID: 275056 [Multi-domain]  Cd Length: 198  Bit Score: 43.84  E-value: 1.15e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2775742966   1 RSGPSTSNSIVGKAYKGNTVDILS-SSNGWYKVKLSNGQVGWGSSDYIS 48
Cdd:TIGR04211  11 RSGPGNQYRILGSLKSGTPVTVLErSEDGYSRVRTPKGREGWVLSRYLS 59
YgiM COG3103
Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family ...
 1-41 4.77e-05

Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family [General function prediction only];


Pssm-ID: 442337 [Multi-domain]  Cd Length: 119  Bit Score: 41.26  E-value: 4.77e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2775742966   1 RSGPSTSNSIVGKAYKGNTVDILSSSNGWYKVKLSNgqVGW 41
Cdd:COG3103    80 RAGPSTSSEVLGLLPKGETVTVLKKSGGWFKVGYRG--TGW 118
PRK11479 PRK11479
YaeF family permuted papain-like enzyme;
110-189 4.95e-05

YaeF family permuted papain-like enzyme;


Pssm-ID: 183157  Cd Length: 274  Bit Score: 42.54  E-value: 4.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2775742966 110 IKMPRTSREQANVGTTVSQSQLQPGDLIFSSTDG--SGG--------VNHVGIYIGNGQMIHAPKPGdvVKTTNINSSYW 179
Cdd:PRK11479   44 VKFQHQSSFTEQGIKEITAPDLKPGDLLFSSSLGvtSFGirvfstssVSHVAIYLGENNVAEATGAG--VQIVSLKKAIK 121

                          90
                  ....*....|
gi 2775742966 180 QNTYVKAKRV 189
Cdd:PRK11479  122 HSDKLFALRV 131
SH3_4 pfam06347
Bacterial SH3 domain; SH3 (src Homology-3) domains are small protein modules containing ...
 1-41 1.84e-03

Bacterial SH3 domain; SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues. They are found in a great variety of intracellular or membrane-associated proteins, in a variety of proteins with enzymatic activity, in adaptor proteins, such as fodrin and yeast actin binding protein ABP-1. The SH3 domain has a characteriztic fold which consists of five or six beta-strands arranged as two tightly packed anti-parallel beta sheets. The linker regions may contain short helices. The surface of the SH3-domain bears a flat, hydrophobic ligand-binding pocket which consists of three shallow grooves defined by conservative aromatic residues in which the ligand adopts an extended left-handed helical arrangement. The ligand binds with low affinity but this may be enhanced by multiple interactions. The region bound by the SH3 domain is in all cases proline-rich and contains PXXP as a core-conserved binding motif. The function of the SH3 domain is not well understood but they may mediate many diverse processes such as increasing local concentration of proteins, altering their subcellular location and mediating the assembly of large multiprotein complexes. This family consists of several hypothetical bacterial proteins of unknown function, but that contain an SH-3 region. Family members include probable invasion-associated protein p60 that are conceptually translated from iap genes. The iap gene, which is regarded as a virulence-associated gene in L. monocytogenes, codes for a gene product that has murein-lytic activity and is involved in cell division.


Pssm-ID: 428898 [Multi-domain]  Cd Length: 56  Bit Score: 35.40  E-value: 1.84e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2775742966   1 RSGPSTSNSIVGKAYKGNTVDILSSSNGWYKVKLSNGQVGW 41
Cdd:pfam06347   8 RRGPSDKAAVAAYLEAGVPVRVVACKDNWCRVRDADGAEGW 48
SH3_Nck_2 cd11766
Second Src Homology 3 domain of Nck adaptor proteins; Nck adaptor proteins regulate actin ...
 16-49 4.32e-03

Second Src Homology 3 domain of Nck adaptor proteins; Nck adaptor proteins regulate actin cytoskeleton dynamics by linking proline-rich effector molecules to protein tyrosine kinases and phosphorylated signaling intermediates. They contain three SH3 domains and a C-terminal SH2 domain. They function downstream of the PDGFbeta receptor and are involved in Rho GTPase signaling and actin dynamics. Vertebrates contain two Nck adaptor proteins: Nck1 (also called Nckalpha) and Nck2 (also called Nckbeta or Growth factor receptor-bound protein 4, Grb4), which show partly overlapping functions but also bind distinct targets. Their SH3 domains are involved in recruiting downstream effector molecules, such as the N-WASP/Arp2/3 complex, which when activated induces actin polymerization that results in the production of pedestals, or protrusions of the plasma membrane. The second SH3 domain of Nck appears to prefer ligands containing the APxxPxR motif. SH3 domains are protein interaction domains that usually bind to proline-rich ligands with moderate affinity and selectivity, preferentially a PxxP motif. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.


Pssm-ID: 212700 [Multi-domain]  Cd Length: 53  Bit Score: 34.16  E-value: 4.32e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2775742966  16 KGNTVDIL-SSSNGWYKVKLsNGQVGWGSSDYISK 49
Cdd:cd11766    20 KGDRVLVLeKSSDGWWRGEC-NGQVGWFPSNYVTE 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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