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Conserved domains on  [gi|2776880571|ref|WP_367881937|]
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transcription antiterminator [Anaerofustis stercorihominis]

Protein Classification

BglG family transcription antiterminator( domain architecture ID 11467243)

BglG family transcription antiterminator similar to Bacillus subtilis transcriptional regulator MtlR that positively regulates the expression of the mtlAFD operon, which is involved in the uptake and catabolism of mannitol

Gene Ontology:  GO:0006355|GO:0009401|GO:0008982
PubMed:  15802242|9305643

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BglG COG3711
Transcriptional antiterminator [Transcription];
8-622 1.33e-61

Transcriptional antiterminator [Transcription];


:

Pssm-ID: 442925 [Multi-domain]  Cd Length: 618  Bit Score: 216.26  E-value: 1.33e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571   8 ILEQLLYRGKNYKIEELAKYYDVSQKTLQNDFSDINTFLKEINIPqltVLKSGEIKLFDKKFDEYTIEKLNKLGNIQYIM 87
Cdd:COG3711     1 ILKILLKNNNVVTAKELAKKLNVSERTIRYDIKKINEWLKKNGLE---IISKKGIGFRLDIDDEQKEKLLQLLEKSEDPL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571  88 EKKERVNLIIIILLKESKFITMNQLAEKLCVTRITILNDMIEVNLKLNKYNIEVLSKPGKGIIAAYDEYDARCLITHLLF 167
Cdd:COG3711    78 SPKERVAYILLRLLLAGDPISLDDLAEELFVSRSTILNDLKKIEKILKKYGLTLERKPNYGIKLEGSELDIRKALAELLS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 168 DSYHSNERESNISNVYFiklikeieNNYTLESLKNILDEIIIDKKYDFRNRGYYAILFSLFVILNRRSNEITYIEENKRY 247
Cdd:COG3711   158 ELLSENDLLSLLLLKLI--------PEEDLELIEEIIEEAEKKLGIKLSDSIYINLTDHIAIAIKRIKKGKYIKLDNPLL 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 248 ----SNKEYDIAKEIYEILTKKLDIIPNKNDIHYLAG-FISNKDILKPLINVDDYVELHNTVATFLYKISEQLDISLYDE 322
Cdd:COG3711   230 weikKPKEYEIAKEILKLIEERLGISLPEDEIGYIALhLLGARLNNDNELSEIITLEITKLIKEIINIIEEELGIDLDED 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 323 YSLFEFLIKHLNAMAMRIKNEELLINPIYEQLKEKYDYVFKAVKENIRLIEDFYKLKIDKNELSYIVMHICAEIEREtTK 402
Cdd:COG3711   310 SLLYERLITHLKPAINRLKYGIPIRNPLLEEIKEKYPEAFELAKKIAKYLEKELGIEIPEDEIGYLTLHFGAALERQ-KE 388

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 403 MRKPSILIVCPESMAAGQLIAAQLEKYF-DFNIKAIITDS-YEISDNLNIDFIISTVVLPrlKYPVLIINTIIDAEDYNR 480
Cdd:COG3711   389 SKKKRVLVVCSSGIGTSRLLKSRLKKLFpEIEIIDVISYReLEEIDLEDYDLIISTVPLE--DKPVIVVSPLLTEEDIEK 466

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 481 IQTIIFSLIKDYKKLKKSIENKEsltlpgikhrlyQSINPSLIKITDDITSWEEVLRQGGDLLINAGYASKDFSDDLIKS 560
Cdd:COG3711   467 IRKFLKQIKKKLAKILFELLLLL------------LLLEEKEIIILLLLLLIEEALAADAIEELEEEEIEEELEEIIIII 534

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2776880571 561 ANLNGPYFVIRKGVGLAHALSKDSNYESAISLTVLKNGVKFNHPYNDPVKLLFSLVIKDSKS 622
Cdd:COG3711   535 VIAIPIIIIIIIAIIVLAAEEPGVIKLILVLLLLLILIILLEDDEALLVILLLLLLLIESSL 596
 
Name Accession Description Interval E-value
BglG COG3711
Transcriptional antiterminator [Transcription];
8-622 1.33e-61

Transcriptional antiterminator [Transcription];


Pssm-ID: 442925 [Multi-domain]  Cd Length: 618  Bit Score: 216.26  E-value: 1.33e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571   8 ILEQLLYRGKNYKIEELAKYYDVSQKTLQNDFSDINTFLKEINIPqltVLKSGEIKLFDKKFDEYTIEKLNKLGNIQYIM 87
Cdd:COG3711     1 ILKILLKNNNVVTAKELAKKLNVSERTIRYDIKKINEWLKKNGLE---IISKKGIGFRLDIDDEQKEKLLQLLEKSEDPL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571  88 EKKERVNLIIIILLKESKFITMNQLAEKLCVTRITILNDMIEVNLKLNKYNIEVLSKPGKGIIAAYDEYDARCLITHLLF 167
Cdd:COG3711    78 SPKERVAYILLRLLLAGDPISLDDLAEELFVSRSTILNDLKKIEKILKKYGLTLERKPNYGIKLEGSELDIRKALAELLS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 168 DSYHSNERESNISNVYFiklikeieNNYTLESLKNILDEIIIDKKYDFRNRGYYAILFSLFVILNRRSNEITYIEENKRY 247
Cdd:COG3711   158 ELLSENDLLSLLLLKLI--------PEEDLELIEEIIEEAEKKLGIKLSDSIYINLTDHIAIAIKRIKKGKYIKLDNPLL 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 248 ----SNKEYDIAKEIYEILTKKLDIIPNKNDIHYLAG-FISNKDILKPLINVDDYVELHNTVATFLYKISEQLDISLYDE 322
Cdd:COG3711   230 weikKPKEYEIAKEILKLIEERLGISLPEDEIGYIALhLLGARLNNDNELSEIITLEITKLIKEIINIIEEELGIDLDED 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 323 YSLFEFLIKHLNAMAMRIKNEELLINPIYEQLKEKYDYVFKAVKENIRLIEDFYKLKIDKNELSYIVMHICAEIEREtTK 402
Cdd:COG3711   310 SLLYERLITHLKPAINRLKYGIPIRNPLLEEIKEKYPEAFELAKKIAKYLEKELGIEIPEDEIGYLTLHFGAALERQ-KE 388

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 403 MRKPSILIVCPESMAAGQLIAAQLEKYF-DFNIKAIITDS-YEISDNLNIDFIISTVVLPrlKYPVLIINTIIDAEDYNR 480
Cdd:COG3711   389 SKKKRVLVVCSSGIGTSRLLKSRLKKLFpEIEIIDVISYReLEEIDLEDYDLIISTVPLE--DKPVIVVSPLLTEEDIEK 466

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 481 IQTIIFSLIKDYKKLKKSIENKEsltlpgikhrlyQSINPSLIKITDDITSWEEVLRQGGDLLINAGYASKDFSDDLIKS 560
Cdd:COG3711   467 IRKFLKQIKKKLAKILFELLLLL------------LLLEEKEIIILLLLLLIEEALAADAIEELEEEEIEEELEEIIIII 534

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2776880571 561 ANLNGPYFVIRKGVGLAHALSKDSNYESAISLTVLKNGVKFNHPYNDPVKLLFSLVIKDSKS 622
Cdd:COG3711   535 VIAIPIIIIIIIAIIVLAAEEPGVIKLILVLLLLLILIILLEDDEALLVILLLLLLLIESSL 596
PTS_EIIA_2 pfam00359
Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;
518-656 4.62e-23

Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;


Pssm-ID: 459780 [Multi-domain]  Cd Length: 139  Bit Score: 95.35  E-value: 4.62e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 518 INPSLIKITDDITSWEEVLRQGGDLLINAGYASKDFSDDLIKSANLNGPYFVIrkGVGLAHALSKDSNyESAISLTVLKN 597
Cdd:pfam00359   2 LDKELIFLNLEAKSKEEAIEFLADKLVEAGYVEPAYLEAILEREKEGSTGIGN--GIAIPHARSEAVK-KPGIAVLTLKE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 598 GVKFNHPYNDPVKLLFSLVIKDS-KSYLNIFNDVLKLSTNKDFTHGVINAKSEKEVYDII 656
Cdd:pfam00359  79 PVDFGSEDGKPVKLIFLLAAPDNeASHLKILSQLARLLQDEEFVEKLLKAKDPEEILEIL 138
cmtB PRK09854
PTS mannitol transporter subunit IIA;
513-658 7.11e-16

PTS mannitol transporter subunit IIA;


Pssm-ID: 182114 [Multi-domain]  Cd Length: 147  Bit Score: 75.03  E-value: 7.11e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 513 RLYQSINPSLIKITDDITSWEEVLRQGGDLLINAGYASKDFSDDLIKSANLNGPYFVIRKGVGLAHALSKDSNYESAISL 592
Cdd:PRK09854    2 RLSDYFPESSISVIHSAKDWQEAIDFSMVSLLDKNYISENYIQAIKDSTINNGPYYILAPGVAMPHARPECGALKTGMSL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2776880571 593 TVLKNGVKFnhPYND-PVKLLFSLVIKDSKSYLNIFNDVLKLSTNKDFTHGVINAKSEKEVYDIIVK 658
Cdd:PRK09854   82 TLLEQGVYF--PGNDePIKLLIGLSAADADSHIGAIQALSELLCEEEILEQLLTASSEKQLADIISR 146
PTS_IIB_bgl_like cd05568
PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory ...
 408-485 7.69e-13

PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved in sugar utilization. The domain architecture of the IIB-containing protein includes a region N-terminal to the IIB domain which is homologous to the BglG transcription antiterminator with an RNA-binding domain followed by two homologous domains, PRD1 and PRD2 (PTS Regulation Domains). C-terminal to the IIB domain is a domain similar to the PTS IIA domain. In this system, the BglG-like region and the IIB and IIA-like domains are all expressed together as a single multidomain protein. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include this sensory system with similarity to the bacterial bgl system, chitobiose/lichenan, ascorbate, lactose, galactitol, mannitol, and fructose systems.


Pssm-ID: 99910  Cd Length: 85  Bit Score: 64.45  E-value: 7.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 408 ILIVCPESMAAGQLIAAQLEKYFDFN--IKAIITDSYEISDNLNIDFIISTVVLPRLKYPVLIINTIIDAEDYNRIQTII 485
Cdd:cd05568     3 ALVVCPSGIGTSRLLKSKLKKLFPEIeiIDVISLRELEEVDLDDYDLIISTVPLEDTDKPVIVVSPILTEEDIKKIRKFI 82
 
Name Accession Description Interval E-value
BglG COG3711
Transcriptional antiterminator [Transcription];
8-622 1.33e-61

Transcriptional antiterminator [Transcription];


Pssm-ID: 442925 [Multi-domain]  Cd Length: 618  Bit Score: 216.26  E-value: 1.33e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571   8 ILEQLLYRGKNYKIEELAKYYDVSQKTLQNDFSDINTFLKEINIPqltVLKSGEIKLFDKKFDEYTIEKLNKLGNIQYIM 87
Cdd:COG3711     1 ILKILLKNNNVVTAKELAKKLNVSERTIRYDIKKINEWLKKNGLE---IISKKGIGFRLDIDDEQKEKLLQLLEKSEDPL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571  88 EKKERVNLIIIILLKESKFITMNQLAEKLCVTRITILNDMIEVNLKLNKYNIEVLSKPGKGIIAAYDEYDARCLITHLLF 167
Cdd:COG3711    78 SPKERVAYILLRLLLAGDPISLDDLAEELFVSRSTILNDLKKIEKILKKYGLTLERKPNYGIKLEGSELDIRKALAELLS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 168 DSYHSNERESNISNVYFiklikeieNNYTLESLKNILDEIIIDKKYDFRNRGYYAILFSLFVILNRRSNEITYIEENKRY 247
Cdd:COG3711   158 ELLSENDLLSLLLLKLI--------PEEDLELIEEIIEEAEKKLGIKLSDSIYINLTDHIAIAIKRIKKGKYIKLDNPLL 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 248 ----SNKEYDIAKEIYEILTKKLDIIPNKNDIHYLAG-FISNKDILKPLINVDDYVELHNTVATFLYKISEQLDISLYDE 322
Cdd:COG3711   230 weikKPKEYEIAKEILKLIEERLGISLPEDEIGYIALhLLGARLNNDNELSEIITLEITKLIKEIINIIEEELGIDLDED 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 323 YSLFEFLIKHLNAMAMRIKNEELLINPIYEQLKEKYDYVFKAVKENIRLIEDFYKLKIDKNELSYIVMHICAEIEREtTK 402
Cdd:COG3711   310 SLLYERLITHLKPAINRLKYGIPIRNPLLEEIKEKYPEAFELAKKIAKYLEKELGIEIPEDEIGYLTLHFGAALERQ-KE 388

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 403 MRKPSILIVCPESMAAGQLIAAQLEKYF-DFNIKAIITDS-YEISDNLNIDFIISTVVLPrlKYPVLIINTIIDAEDYNR 480
Cdd:COG3711   389 SKKKRVLVVCSSGIGTSRLLKSRLKKLFpEIEIIDVISYReLEEIDLEDYDLIISTVPLE--DKPVIVVSPLLTEEDIEK 466

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 481 IQTIIFSLIKDYKKLKKSIENKEsltlpgikhrlyQSINPSLIKITDDITSWEEVLRQGGDLLINAGYASKDFSDDLIKS 560
Cdd:COG3711   467 IRKFLKQIKKKLAKILFELLLLL------------LLLEEKEIIILLLLLLIEEALAADAIEELEEEEIEEELEEIIIII 534

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2776880571 561 ANLNGPYFVIRKGVGLAHALSKDSNYESAISLTVLKNGVKFNHPYNDPVKLLFSLVIKDSKS 622
Cdd:COG3711   535 VIAIPIIIIIIIAIIVLAAEEPGVIKLILVLLLLLILIILLEDDEALLVILLLLLLLIESSL 596
PTS_EIIA_2 pfam00359
Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;
518-656 4.62e-23

Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;


Pssm-ID: 459780 [Multi-domain]  Cd Length: 139  Bit Score: 95.35  E-value: 4.62e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 518 INPSLIKITDDITSWEEVLRQGGDLLINAGYASKDFSDDLIKSANLNGPYFVIrkGVGLAHALSKDSNyESAISLTVLKN 597
Cdd:pfam00359   2 LDKELIFLNLEAKSKEEAIEFLADKLVEAGYVEPAYLEAILEREKEGSTGIGN--GIAIPHARSEAVK-KPGIAVLTLKE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 598 GVKFNHPYNDPVKLLFSLVIKDS-KSYLNIFNDVLKLSTNKDFTHGVINAKSEKEVYDII 656
Cdd:pfam00359  79 PVDFGSEDGKPVKLIFLLAAPDNeASHLKILSQLARLLQDEEFVEKLLKAKDPEEILEIL 138
PtsN COG1762
Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate ...
 513-659 2.44e-22

Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 441368 [Multi-domain]  Cd Length: 150  Bit Score: 93.76  E-value: 2.44e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 513 RLYQSINPSLIKITDDITSWEEVLRQGGDLLINAGYAS--KDFSDDLIKSANLNGPYfvIRKGVGLAHALSKDSNyESAI 590
Cdd:COG1762     2 MLSDLLTPELILLDLEASSKEEAIEELAELLAEKGYVLdkEEYLEALLEREELGSTG--IGPGIAIPHARPEGVK-KPGI 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2776880571 591 SLTVLKNGVKFNHPYNDPVKLLFSLVI--KDSKSYLNIFNDVLKLSTNKDFTHGVINAKSEKEVYDIIVKE 659
Cdd:COG1762    79 AVARLKEPVDFGAMDGEPVDLVFLLAApeDDSEEHLKLLAELARLLSDEEFREKLLNAKSPEEILELLKEA 149
cmtB PRK09854
PTS mannitol transporter subunit IIA;
513-658 7.11e-16

PTS mannitol transporter subunit IIA;


Pssm-ID: 182114 [Multi-domain]  Cd Length: 147  Bit Score: 75.03  E-value: 7.11e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 513 RLYQSINPSLIKITDDITSWEEVLRQGGDLLINAGYASKDFSDDLIKSANLNGPYFVIRKGVGLAHALSKDSNYESAISL 592
Cdd:PRK09854    2 RLSDYFPESSISVIHSAKDWQEAIDFSMVSLLDKNYISENYIQAIKDSTINNGPYYILAPGVAMPHARPECGALKTGMSL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2776880571 593 TVLKNGVKFnhPYND-PVKLLFSLVIKDSKSYLNIFNDVLKLSTNKDFTHGVINAKSEKEVYDIIVK 658
Cdd:PRK09854   82 TLLEQGVYF--PGNDePIKLLIGLSAADADSHIGAIQALSELLCEEEILEQLLTASSEKQLADIISR 146
PRK10372 PRK10372
PTS ascorbate transporter subunit IIA;
523-656 4.42e-14

PTS ascorbate transporter subunit IIA;


Pssm-ID: 182417 [Multi-domain]  Cd Length: 154  Bit Score: 70.00  E-value: 4.42e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 523 IKITDDITSWEEVLRQGGDLLINAGYASKDFSDDLIKSANLNGPYFVIRKGVGLAHALSKDSNYESAISLTVLKNGVKFN 602
Cdd:PRK10372   13 IRLQAEAETWQEAVKIGVDLLVAADVVEPRYYQAILDGVEQFGPYFVIAPGLAMPHGRPEEGVKKTGFALVTLKKPLEFN 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2776880571 603 HPYNDPVKLLFSLVIKDSKSY--------LNIFNDvlklstNKDFTHgVINAKSEKEVYDII 656
Cdd:PRK10372   93 HEDNDPVDILITMAAVDANTHqevgimqiVNLFED------EANFDR-LRACRTEQEVLDLI 147
PTS_IIB_bgl_like cd05568
PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory ...
 408-485 7.69e-13

PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved in sugar utilization. The domain architecture of the IIB-containing protein includes a region N-terminal to the IIB domain which is homologous to the BglG transcription antiterminator with an RNA-binding domain followed by two homologous domains, PRD1 and PRD2 (PTS Regulation Domains). C-terminal to the IIB domain is a domain similar to the PTS IIA domain. In this system, the BglG-like region and the IIB and IIA-like domains are all expressed together as a single multidomain protein. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include this sensory system with similarity to the bacterial bgl system, chitobiose/lichenan, ascorbate, lactose, galactitol, mannitol, and fructose systems.


Pssm-ID: 99910  Cd Length: 85  Bit Score: 64.45  E-value: 7.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 408 ILIVCPESMAAGQLIAAQLEKYFDFN--IKAIITDSYEISDNLNIDFIISTVVLPRLKYPVLIINTIIDAEDYNRIQTII 485
Cdd:cd05568     3 ALVVCPSGIGTSRLLKSKLKKLFPEIeiIDVISLRELEEVDLDDYDLIISTVPLEDTDKPVIVVSPILTEEDIKKIRKFI 82
PRD pfam00874
PRD domain; The PRD domain (for PTS Regulation Domain), is the phosphorylatable regulatory ...
 307-392 5.41e-11

PRD domain; The PRD domain (for PTS Regulation Domain), is the phosphorylatable regulatory domain found in bacterial transcriptional antiterminator such as BglG, SacY and LicT, as well as in activators such as MtlR and LevR. The PRD is phosphorylated on one or two conserved histidine residues. PRD-containing proteins are involved in the regulation of catabolic operons in Gram+ and Gram- bacteria and are often characterized by a short N-terminal effector domain that binds to either RNA (CAT-RBD for antiterminators pfam03123) or DNA (for activators), and a duplicated PRD module which is phosphorylated by the sugar phosphotransferase system (PTS) in response to the availability of carbon source. The phosphorylations modify the conformation and stability of the dimeric proteins and thereby the RNA- or DNA-binding activity of the effector domain. The structure of the LicT PRD domains has been solved in both the active (pdb:1h99) and inactive state (pdb:1tlv), revealing massive structural rearrangements upon activation.


Pssm-ID: 459973 [Multi-domain]  Cd Length: 90  Bit Score: 59.19  E-value: 5.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 307 FLYKISEQLDISLYDEySLFEFLIKHLNAMAMRIKNEELLINPIYEQLKEKYDYVFKAVKENIRLIEDFYKLKIDKNELS 386
Cdd:pfam00874   3 IIELIEKKLGITFDDD-ILYIRLILHLAFAIERIKEGITIENPLLEEIKEKYPKEFEIAKKILEILEEELGIELPEDEIG 81


                  ....*.
gi 2776880571 387 YIVMHI 392
Cdd:pfam00874  82 YIALHF 87
MtlA2 COG4668
Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and ...
 518-659 7.54e-08

Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism];


Pssm-ID: 443705 [Multi-domain]  Cd Length: 143  Bit Score: 51.70  E-value: 7.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 518 INPSLIKITDDITSWEEVLRQGGDLLINAGYASKDFSDDLIKSANLNGPYfvIRKGVGLAHALSKDSNY--ESAISLTVL 595
Cdd:COG4668     4 LTKENIRLNASAANKEEAIRLAGQLLVEAGYVEPEYIDAMLEREAQVSTY--LGNGIAIPHGTNEAKDLvlKTGISVLQF 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2776880571 596 KNGVKFNHpyNDPVKLLFSLVIKdSKSYLNIFNDVLKLSTNKDFTHGVINAKSEKEVYDIIVKE 659
Cdd:COG4668    82 PDGVDWGD--GNTVYLVIGIAAK-SDEHLEILRQLARVLSDEENVEKLAKATDAEEILALLTGE 142
PTS_IIB cd00133
PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the ...
 408-485 7.99e-08

PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include chitobiose/lichenan, ascorbate, lactose, galactitol, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system. The PTS is found only in bacteria, where it catalyzes the transport and phosphorylation of numerous monosaccharides, disaccharides, polyols, amino sugars, and other sugar derivatives. The four proteins (domains) forming the PTS phosphorylation cascade (EI, HPr, EIIA, and EIIB), can phosphorylate or interact with numerous non-PTS proteins thereby regulating their activity.


Pssm-ID: 99904  Cd Length: 84  Bit Score: 49.95  E-value: 7.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 408 ILIVCPESMAAGQLIAAQLEKYF---DFNIKAIITDSYEISDNLNIDFIISTVVLPRLKY--PVLIINTIIDAEDYNRIQ 482
Cdd:cd00133     2 ILVVCGSGIGSSSMLAEKLEKAAkelGIEVKVEAQGLSEVIDLADADLIISTVPLAARFLgkPVIVVSPLLNEKDGEKIL 81


                  ...
gi 2776880571 483 TII 485
Cdd:cd00133    82 EKL 84
LevR COG3933
Transcriptional regulatory protein LevR, contains PRD, AAA+ and EIIA domains [Transcription];
178-412 2.49e-06

Transcriptional regulatory protein LevR, contains PRD, AAA+ and EIIA domains [Transcription];


Pssm-ID: 443134 [Multi-domain]  Cd Length: 916  Bit Score: 50.89  E-value: 2.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 178 NISNVYFIKLIKEIENNYTLESLKNILDEIIIDKKYDFRNR-----GYYAILFSLFVILNRRSNEITYIEENKRYSNKEY 252
Cdd:COG3933   327 LIKAAAAAALAKAIKEATIILRLLSKLLKLLLLLLLNERLLllelkILIEPLDIFFDSSASSDESDESEEDENLYEIIEI 406

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 253 DIAKEIYEILTKKLDIIPNKNDI-HYLAGFISNKDILKPLINVDDYV--ELHNTVATFLYKISEQLDISLYDeySLFEFL 329
Cdd:COG3933   407 KKKLLLELGIDEEEINIIIEIDIdVHLLKFIYDDNKNFNKEELAKIVdeDIINVVEEILELAEKKLGRKFSE--NFIYAL 484

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 330 IKHLNAMAMRIKNEELLINPIYEQLKEKYDYVFKAVKENIRLIEDFYKLKIDKNELSYIVMHICAEIERETTKmrKPSIL 409
Cdd:COG3933   485 SLHLSSFIERIKEGKEIINPNLNEIKKKYPKEFKVAKEIKELIEQELDIEIPEDEVGFLTLFLVSLNENNESG--KVGVI 562


                  ...
gi 2776880571 410 IVC 412
Cdd:COG3933   563 VLA 565
PspF COG1221
Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain ...
 251-438 6.81e-06

Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription, Signal transduction mechanisms];


Pssm-ID: 440834 [Multi-domain]  Cd Length: 835  Bit Score: 49.34  E-value: 6.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 251 EYDIAKEIYEILTKKLDIIPNK------------NDIH-YLAGFISNKDILKPLINVDDYVELHNTVATFLYKISEQLDI 317
Cdd:COG1221   406 EYELPYNFYEIIEDKYEELKSEglseeeinkiisKDIEsYFKKLIFKLDKSNISEELLLIVVDEVIVNVVEIFEEAEKKL 485

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 318 SLYDEYSLFEFLIKHLNAMAMRIKNEELLINPIYEQLKEKYDYVFKAVKENIRLIEDFYKLKIDKNELSYIVMHICAEIE 397
Cdd:COG1221   486 LRYNSSNLFIALSLHLLSTLLRIKKGKKIINPQLNEIKKKYYEEFILAAEAIKIIEEELKILIPDEEEGFILLLLIELKE 565

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2776880571 398 RETTKMRKPSILIVCPESMAAGQLIAAQLEKYFDFNIKAII 438
Cdd:COG1221   566 EKSLSENVIVVVVIAHGGAAASSSMAVVNLLLLEVAVAAID 606
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 94-149 2.71e-05

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 42.03  E-value: 2.71e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2776880571  94 NLIIIILLKESKFITMNQLAEKLCVTRITILNDMievnLKLNKYNIEVLSKPGKGI 149
Cdd:pfam08279   1 LQILQLLLEARGPISGQELAEKLGVSRRTIRRDI----KILEELGVPIEAEPGRGY 52
PRK09863 PRK09863
putative frv operon regulatory protein; Provisional
 22-485 1.93e-04

putative frv operon regulatory protein; Provisional


Pssm-ID: 182121 [Multi-domain]  Cd Length: 584  Bit Score: 44.46  E-value: 1.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571  22 EELAKYYDVSQKTLQNDFSDINTFLKEINIPQLTVLKsgeiklfdkkfdEYTIEKLNKLGNIQYIMEKKERVNLIIIILL 101
Cdd:PRK09863   21 GELAQQLGVSRRTIVRDIAYINFTLNGKAIGSISGSA------------KYHLEILNRRSLFQLLQKSDNEDRLLLLRLL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 102 KeSKFITMNQLAEKLCVTRITILNDMIEVNLKLNKYnIEVLSKPGKGIIAAYDEYDARCLITHLLFDSYHSNEresnisn 181
Cdd:PRK09863   89 L-NTFTPMAQLASALNLSRTWVAERLPRLNQRYERI-CCIASRPGLGHFIDETEEKRIDILANLIRKDPQLIP------- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 182 vyfiKLIKEIENnytLESLKNILDEIIidKKYDFRNRGYYAILFSLFVILnrrSNEITYIEENKRYSnkeydiakEIYEI 261
Cdd:PRK09863  160 ----KAGPTRDN---LQHLSRTACDNQ--HRWPLMQGDYLSSLILAIYAL---RNQLTDEWPQYPGD--------EIKQI 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 262 LTKKLDIIPNkNDIHYLAGFISNKDILKPLINVDDYVELHNTVATFLykiseQLDISlydEYSLFEFLIKHL--NAMAMR 339
Cdd:PRK09863  220 VEHSGLFLGD-NAVRTLTGLIEKQHQQAQVISADNVQQLLQRVPGIA-----SLNAI---DTQLVENIFGHLlrCLAFPV 290

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2776880571 340 IKNEELL--INPIYEQLKEKYDYVFKAVKEnirLIEDFYKLKIDKNelsYIVMHICAEIERETTKmRKPSILIVCPESMA 417
Cdd:PRK09863  291 WIAEHRQssINNLKAQNPAAFDMALHFITL---LREQLDIPLFDSD---LIALYFACALERHQNE-RVPILLLADQNSIA 363

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2776880571 418 A-GQLIAAQLEKYFDFNIKAIITDSYEISDNLNIDFIISTVVLPR-LKYPV---LIINTIIDAEDYNRIQTII 485
Cdd:PRK09863  364 TiNQLIIEQKVLNIRVIIVRSLSELEAIREEIEPLLIINNSHYLVdLQDAInfyITFKNVITAAGIEQLKHLL 436
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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