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Conserved domains on  [gi|2777341912|ref|WP_367887766|]
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NADPH-dependent F420 reductase [Pseudogemmatithrix spongiicola]

Protein Classification

NADPH-dependent F420 reductase( domain architecture ID 11449986)

NADPH-dependent F420 reductase may be part of a F420-dependent NADP oxidoreductase catalyzing the reduction of NADP(+) with F420H(2) via hydride transfer, as well as the reverse reaction, the reduction of F420 with NADPH

CATH:  3.40.50.720
EC:  1.-.-.-
Gene Ontology:  GO:0052851|GO:0016491|GO:0070967|GO:0016651
SCOP:  4000104

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG2085 COG2085
Predicted dinucleotide-binding enzyme [General function prediction only];
3-162 6.00e-51

Predicted dinucleotide-binding enzyme [General function prediction only];


:

Pssm-ID: 441688 [Multi-domain]  Cd Length: 205  Bit Score: 165.34  E-value: 6.00e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2777341912   3 IAILGAGKVGQTLGARFREVGHDVRYAVRNPADPKYAV--LGAAARPV--ADAVRDAELVLLATPWSAAEAAIVGAG-SL 77
Cdd:COG2085     1 IGIIGTGNIGSALARRLAAAGHEVVIGSRDPEKAAALAaeLGPGARAGtnAEAAAAADVVVLAVPYEAVPDVLESLGdAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2777341912  78 AGKILVDATNPIGA--GGVLTHGRDDSGAEQVARWAPGARVVKAFNTIGREVMAN-ATFQGRPAVLWLCGDDAAATRVVA 154
Cdd:COG2085    81 AGKIVIDATNPLPErdGFILDPPGGGSAAELVAALLPGARVVKAFNTIGAAVLADpARPAGGRRDVFVAGDDAEAKAVVA 160


                  ....*...
gi 2777341912 155 DLAAAIGF 162
Cdd:COG2085   161 ALIEDLGF 168
 
Name Accession Description Interval E-value
COG2085 COG2085
Predicted dinucleotide-binding enzyme [General function prediction only];
3-162 6.00e-51

Predicted dinucleotide-binding enzyme [General function prediction only];


Pssm-ID: 441688 [Multi-domain]  Cd Length: 205  Bit Score: 165.34  E-value: 6.00e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2777341912   3 IAILGAGKVGQTLGARFREVGHDVRYAVRNPADPKYAV--LGAAARPV--ADAVRDAELVLLATPWSAAEAAIVGAG-SL 77
Cdd:COG2085     1 IGIIGTGNIGSALARRLAAAGHEVVIGSRDPEKAAALAaeLGPGARAGtnAEAAAAADVVVLAVPYEAVPDVLESLGdAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2777341912  78 AGKILVDATNPIGA--GGVLTHGRDDSGAEQVARWAPGARVVKAFNTIGREVMAN-ATFQGRPAVLWLCGDDAAATRVVA 154
Cdd:COG2085    81 AGKIVIDATNPLPErdGFILDPPGGGSAAELVAALLPGARVVKAFNTIGAAVLADpARPAGGRRDVFVAGDDAEAKAVVA 160


                  ....*...
gi 2777341912 155 DLAAAIGF 162
Cdd:COG2085   161 ALIEDLGF 168
F420_oxidored pfam03807
NADP oxidoreductase coenzyme F420-dependent;
4-88 8.76e-12

NADP oxidoreductase coenzyme F420-dependent;


Pssm-ID: 397743 [Multi-domain]  Cd Length: 92  Bit Score: 59.94  E-value: 8.76e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2777341912   4 AILGAGKVGQTLGARFREVG-HDVRYA-VRNPAD-----PKYAVlGAAARPVADAVRDAELVLLATPWSAAEAAIVGA-G 75
Cdd:pfam03807   1 GFIGAGNMGEALARGLVAAGpHEVVVAnSRNPEKaeelaEEYGV-GATAVDNEEAAEEADVVFLAVKPEDAPDVLSELsD 79

                          90
                  ....*....|...
gi 2777341912  76 SLAGKILVDATNP 88
Cdd:pfam03807  80 LLKGKIVISIAAG 92
PRK06522 PRK06522
2-dehydropantoate 2-reductase; Reviewed
 1-34 1.65e-04

2-dehydropantoate 2-reductase; Reviewed


Pssm-ID: 235821 [Multi-domain]  Cd Length: 304  Bit Score: 42.15  E-value: 1.65e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2777341912   1 MHIAILGAGKVGQTLGARFREVGHDVRYAVRNPA 34
Cdd:PRK06522    1 MKIAILGAGAIGGLFGAALAQAGHDVTLVARRGA 34
 
Name Accession Description Interval E-value
COG2085 COG2085
Predicted dinucleotide-binding enzyme [General function prediction only];
3-162 6.00e-51

Predicted dinucleotide-binding enzyme [General function prediction only];


Pssm-ID: 441688 [Multi-domain]  Cd Length: 205  Bit Score: 165.34  E-value: 6.00e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2777341912   3 IAILGAGKVGQTLGARFREVGHDVRYAVRNPADPKYAV--LGAAARPV--ADAVRDAELVLLATPWSAAEAAIVGAG-SL 77
Cdd:COG2085     1 IGIIGTGNIGSALARRLAAAGHEVVIGSRDPEKAAALAaeLGPGARAGtnAEAAAAADVVVLAVPYEAVPDVLESLGdAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2777341912  78 AGKILVDATNPIGA--GGVLTHGRDDSGAEQVARWAPGARVVKAFNTIGREVMAN-ATFQGRPAVLWLCGDDAAATRVVA 154
Cdd:COG2085    81 AGKIVIDATNPLPErdGFILDPPGGGSAAELVAALLPGARVVKAFNTIGAAVLADpARPAGGRRDVFVAGDDAEAKAVVA 160


                  ....*...
gi 2777341912 155 DLAAAIGF 162
Cdd:COG2085   161 ALIEDLGF 168
F420_oxidored pfam03807
NADP oxidoreductase coenzyme F420-dependent;
4-88 8.76e-12

NADP oxidoreductase coenzyme F420-dependent;


Pssm-ID: 397743 [Multi-domain]  Cd Length: 92  Bit Score: 59.94  E-value: 8.76e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2777341912   4 AILGAGKVGQTLGARFREVG-HDVRYA-VRNPAD-----PKYAVlGAAARPVADAVRDAELVLLATPWSAAEAAIVGA-G 75
Cdd:pfam03807   1 GFIGAGNMGEALARGLVAAGpHEVVVAnSRNPEKaeelaEEYGV-GATAVDNEEAAEEADVVFLAVKPEDAPDVLSELsD 79

                          90
                  ....*....|...
gi 2777341912  76 SLAGKILVDATNP 88
Cdd:pfam03807  80 LLKGKIVISIAAG 92
COG5495 COG5495
Predicted oxidoreductase, contains short-chain dehydrogenase (SDR) and DUF2520 domains ...
 1-83 6.85e-10

Predicted oxidoreductase, contains short-chain dehydrogenase (SDR) and DUF2520 domains [General function prediction only];


Pssm-ID: 444246 [Multi-domain]  Cd Length: 286  Bit Score: 58.28  E-value: 6.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2777341912   1 MHIAILGAGKVGQTLGARFREVGHDVRYAV-RNPADPKYA---VLGAAARPVADAVRDAELVLLATPWSAAE---AAIVG 73
Cdd:COG5495     4 MKIGIIGAGRVGTALAAALRAAGHEVVGVYsRSPASAERAaalLGAVPALDLEELAAEADLVLLAVPDDAIAevaAGLAA 83

                          90
                  ....*....|.
gi 2777341912  74 AGSL-AGKILV 83
Cdd:COG5495    84 AGALrPGQLVV 94
PanE COG1893
Ketopantoate reductase [Coenzyme transport and metabolism]; Ketopantoate reductase is part of ...
 1-159 2.73e-06

Ketopantoate reductase [Coenzyme transport and metabolism]; Ketopantoate reductase is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 441497 [Multi-domain]  Cd Length: 305  Bit Score: 47.54  E-value: 2.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2777341912   1 MHIAILGAGKVGQTLGARFREVGHDVRYAVRNPA------------DPKYAVLGAAARPVADA--VRDAELVLLATPWSA 66
Cdd:COG1893     1 MKIAILGAGAIGGLLGARLARAGHDVTLVARGAHaealrenglrleSPDGDRTTVPVPAVTDPeeLGPADLVLVAVKAYD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2777341912  67 AEAAIVGAGSLAGK--ILVDATNPIGAggvlthgrddsgAEQVARWAPGARVVKAFNTIGREVMANATF-QGRPAVLWL- 142
Cdd:COG1893    81 LEAAAEALAPLLGPdtVVLSLQNGLGH------------EERLAEALGAERVLGGVVTIGATREEPGVVrHTGGGRLVLg 148

                         170       180
                  ....*....|....*....|
gi 2777341912 143 ---CGDDAAATRVVADLAAA 159
Cdd:COG1893   149 eldGGPSERLEALAELLEAA 168
TyrA COG0287
Prephenate dehydrogenase [Amino acid transport and metabolism]; Prephenate dehydrogenase is ...
 1-162 3.04e-05

Prephenate dehydrogenase [Amino acid transport and metabolism]; Prephenate dehydrogenase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440056 [Multi-domain]  Cd Length: 278  Bit Score: 44.35  E-value: 3.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2777341912   1 MHIAILGAGKVGQTLGARFREVGHDVR-YAV-RNPADPKYAV-LGA---AARPVADAVRDAELVLLATPWSAAEAAIVGA 74
Cdd:COG0287     2 MRIAIIGLGLIGGSLALALKRAGLAHEvVGVdRSPETLERALeLGVidrAATDLEEAVADADLVVLAVPVGATIEVLAEL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2777341912  75 GSLAGK--ILVDAT----------NPIGAGG---VLTH---GRDDSGAEQvarwapgarvvkafntigrevmANAT-FQG 135
Cdd:COG0287    82 APHLKPgaIVTDVGsvkgavveaaEALLPDGvrfVGGHpmaGTEKSGPEA----------------------ADADlFEG 139

                         170       180       190
                  ....*....|....*....|....*....|
gi 2777341912 136 RPAVlwLC---GDDAAATRVVADLAAAIGF 162
Cdd:COG0287   140 APYI--LTpteGTDPEALERVEELWEALGA 167
PRK06522 PRK06522
2-dehydropantoate 2-reductase; Reviewed
 1-34 1.65e-04

2-dehydropantoate 2-reductase; Reviewed


Pssm-ID: 235821 [Multi-domain]  Cd Length: 304  Bit Score: 42.15  E-value: 1.65e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2777341912   1 MHIAILGAGKVGQTLGARFREVGHDVRYAVRNPA 34
Cdd:PRK06522    1 MKIAILGAGAIGGLFGAALAQAGHDVTLVARRGA 34
PRK12921 PRK12921
oxidoreductase;
1-32 2.66e-04

oxidoreductase;


Pssm-ID: 183829 [Multi-domain]  Cd Length: 305  Bit Score: 41.38  E-value: 2.66e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2777341912   1 MHIAILGAGKVGQTLGARFREVGHDVRYAVRN 32
Cdd:PRK12921    1 MRIAVVGAGAVGGTFGGRLLEAGRDVTFLVRP 32
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
1-63 3.00e-04

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 41.21  E-value: 3.00e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2777341912   1 MHIAILGAGKVGQTLGARFREVGHDVRYAVRNPAD----------PKY---AVLGAAARPVAD---AVRDAELVLLATP 63
Cdd:PRK00094    2 MKIAVLGAGSWGTALAIVLARNGHDVTLWARDPEQaaeinadrenPRYlpgIKLPDNLRATTDlaeALADADLILVAVP 80
PRK07417 PRK07417
prephenate/arogenate dehydrogenase;
1-63 5.81e-04

prephenate/arogenate dehydrogenase;


Pssm-ID: 180970 [Multi-domain]  Cd Length: 279  Bit Score: 40.26  E-value: 5.81e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2777341912   1 MHIAILGAGKVGQTLGARFREVGHDVRYAVRNPADPKYAVlgaaARPVADAV-------RDAELVLLATP 63
Cdd:PRK07417    1 MKIGIVGLGLIGGSLGLDLRSLGHTVYGVSRRESTCERAI----ERGLVDEAstdlsllKDCDLVILALP 66
trkA PRK09496
Trk system potassium transporter TrkA;
1-64 1.31e-03

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 39.72  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2777341912   1 MHIAILGAGKVGQTLGARFREVGHDV---------------RYAVR----NPADPKyaVLGAAarpvadAVRDAELVLLA 61
Cdd:PRK09496    1 MKIIIVGAGQVGYTLAENLSGENNDVtvidtdeerlrrlqdRLDVRtvvgNGSSPD--VLREA------GAEDADLLIAV 72


                  ...
gi 2777341912  62 TPW 64
Cdd:PRK09496   73 TDS 75
MmsB COG2084
3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport ...
 1-86 2.30e-03

3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism];


Pssm-ID: 441687 [Multi-domain]  Cd Length: 285  Bit Score: 38.56  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2777341912   1 MHIAILGAGKVGQTLGARFREVGHDVRYAVRNPAdpKYAVLGAA-ARPV---ADAVRDAELVLLATPWSAA-EAAIVGAG 75
Cdd:COG2084     2 MKVGFIGLGAMGAPMARNLLKAGHEVTVWNRTPA--KAEALVAAgARVAaspAEAAAAADVVITMLPDDAAvEEVLLGED 79

                          90
                  ....*....|....*.
gi 2777341912  76 SLA-----GKILVDAT 86
Cdd:COG2084    80 GLLaalrpGAVVVDMS 95
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 1-63 4.70e-03

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 37.74  E-value: 4.70e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2777341912   1 MHIAILGAGKVGQTLGARFREVGHDV------RYAVRNPADPKYAVL-GAAARPVA--DA-VRDAELVLLATP 63
Cdd:COG0569    96 MHVIIIGAGRVGRSLARELEEEGHDVvvidkdPERVERLAEEDVLVIvGDATDEEVleEAgIEDADAVIAATG 168
NAD_Gly3P_dh_N pfam01210
NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent ...
 3-63 5.23e-03

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.


Pssm-ID: 395967 [Multi-domain]  Cd Length: 158  Bit Score: 36.79  E-value: 5.23e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2777341912   3 IAILGAGKVGQTLGARFREVGHDVRYAVRNPA----------DPKYA---VLGAAARPVAD---AVRDAELVLLATP 63
Cdd:pfam01210   2 IAVLGAGSWGTALAKVLADNGHEVRLWGRDEElieeinttheNVRYLpgiKLPENLKATTDlaeALKGADIIVIVVP 78
ApbA pfam02558
Ketopantoate reductase PanE/ApbA; This is a family of 2-dehydropantoate 2-reductases also ...
 3-34 6.21e-03

Ketopantoate reductase PanE/ApbA; This is a family of 2-dehydropantoate 2-reductases also known as ketopantoate reductases, EC:1.1.1.169. The reaction catalyzed by this enzyme is: (R)-pantoate + NADP(+) <=> 2-dehydropantoate + NADPH. AbpA catalyzes the NADPH reduction of ketopantoic acid to pantoic acid in the alternative pyrimidine biosynthetic (APB) pathway. ApbA and PanE are allelic. ApbA, the ketopantoate reductase enzyme is required for the synthesis of thiamine via the APB biosynthetic pathway.


Pssm-ID: 426831 [Multi-domain]  Cd Length: 147  Bit Score: 36.06  E-value: 6.21e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2777341912   3 IAILGAGKVGQTLGARFREVGHDVRYAVRNPA 34
Cdd:pfam02558   1 IAILGAGAIGSLLGARLAKAGHDVTLILRGAE 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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