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Conserved domains on  [gi|2786024015|ref|WP_369751177|]
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DNA cytosine methyltransferase [Pseudogulbenkiania sp. NH8B]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Dcm super family cl43082
DNA-cytosine methylase [Replication, recombination and repair];
116-182 1.06e-08

DNA-cytosine methylase [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG0270:

Pssm-ID: 440040 [Multi-domain]  Cd Length: 277  Bit Score: 53.27  E-value: 1.06e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2786024015 116 WRTICAVERDAYAAQVLaqRQNdgclpaFPIWS----DVCSFDGRPWRGLVDVVSGGFPCQDISAAGGGYG 182
Cdd:COG0270    25 FEVVFAVEIDPDACETY--RAN------FPEAKviegDIRDIDPEELIPDVDLLIGGPPCQPFSVAGKRKG 87
DUF1566 super family cl06585
Protein of unknown function (DUF1566); These proteins of unknown function are found in ...
 44-77 9.08e-04

Protein of unknown function (DUF1566); These proteins of unknown function are found in Leptospira interrogans and in several gamma proteobacteria.


The actual alignment was detected with superfamily member pfam07603:

Pssm-ID: 429556 [Multi-domain]  Cd Length: 117  Bit Score: 37.36  E-value: 9.08e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2786024015  44 PTQYSPNNAWNQNFDDGNQNNDHKDNQYRARAVR 77
Cdd:pfam07603  84 TSAGNPDYAWAVNFADGSVGYGNKSSGYYVRLVR 117
 
Name Accession Description Interval E-value
Dcm COG0270
DNA-cytosine methylase [Replication, recombination and repair];
116-182 1.06e-08

DNA-cytosine methylase [Replication, recombination and repair];


Pssm-ID: 440040 [Multi-domain]  Cd Length: 277  Bit Score: 53.27  E-value: 1.06e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2786024015 116 WRTICAVERDAYAAQVLaqRQNdgclpaFPIWS----DVCSFDGRPWRGLVDVVSGGFPCQDISAAGGGYG 182
Cdd:COG0270    25 FEVVFAVEIDPDACETY--RAN------FPEAKviegDIRDIDPEELIPDVDLLIGGPPCQPFSVAGKRKG 87
Cyt_C5_DNA_methylase cd00315
Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many ...
 119-178 1.23e-04

Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects on the mammalian genome. These effects include transcriptional repression via inhibition of transcription factor binding or the recruitment of methyl-binding proteins and their associated chromatin remodeling factors, X chromosome inactivation, imprinting and the suppression of parasitic DNA sequences. DNA methylation is also essential for proper embryonic development and is an important player in both DNA repair and genome stability.


Pssm-ID: 238192 [Multi-domain]  Cd Length: 275  Bit Score: 41.45  E-value: 1.23e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2786024015 119 ICAVERDAYAAQVLaqRQNdgclpaFPIWS---DVCSFDGRPWRGLVDVVSGGFPCQDISAAG 178
Cdd:cd00315    25 VAANEIDKSAAETY--EAN------FPNKLiegDITKIDEKDFIPDIDLLTGGFPCQPFSIAG 79
DUF1566 pfam07603
Protein of unknown function (DUF1566); These proteins of unknown function are found in ...
 44-77 9.08e-04

Protein of unknown function (DUF1566); These proteins of unknown function are found in Leptospira interrogans and in several gamma proteobacteria.


Pssm-ID: 429556 [Multi-domain]  Cd Length: 117  Bit Score: 37.36  E-value: 9.08e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2786024015  44 PTQYSPNNAWNQNFDDGNQNNDHKDNQYRARAVR 77
Cdd:pfam07603  84 TSAGNPDYAWAVNFADGSVGYGNKSSGYYVRLVR 117
DNA_methylase pfam00145
C-5 cytosine-specific DNA methylase;
118-178 1.14e-03

C-5 cytosine-specific DNA methylase;


Pssm-ID: 395093 [Multi-domain]  Cd Length: 324  Bit Score: 38.45  E-value: 1.14e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2786024015 118 TICAVERDAYAAQVLaqRQNdgcLPAFPIwSDVCSFDGRPWRGlVDVVSGGFPCQDISAAG 178
Cdd:pfam00145  24 CVAANEIDKSAAKTY--EAN---FPKVPI-GDITLIDIKDIPD-IDILTGGFPCQDFSIAG 77
 
Name Accession Description Interval E-value
Dcm COG0270
DNA-cytosine methylase [Replication, recombination and repair];
116-182 1.06e-08

DNA-cytosine methylase [Replication, recombination and repair];


Pssm-ID: 440040 [Multi-domain]  Cd Length: 277  Bit Score: 53.27  E-value: 1.06e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2786024015 116 WRTICAVERDAYAAQVLaqRQNdgclpaFPIWS----DVCSFDGRPWRGLVDVVSGGFPCQDISAAGGGYG 182
Cdd:COG0270    25 FEVVFAVEIDPDACETY--RAN------FPEAKviegDIRDIDPEELIPDVDLLIGGPPCQPFSVAGKRKG 87
Cyt_C5_DNA_methylase cd00315
Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many ...
 119-178 1.23e-04

Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects on the mammalian genome. These effects include transcriptional repression via inhibition of transcription factor binding or the recruitment of methyl-binding proteins and their associated chromatin remodeling factors, X chromosome inactivation, imprinting and the suppression of parasitic DNA sequences. DNA methylation is also essential for proper embryonic development and is an important player in both DNA repair and genome stability.


Pssm-ID: 238192 [Multi-domain]  Cd Length: 275  Bit Score: 41.45  E-value: 1.23e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2786024015 119 ICAVERDAYAAQVLaqRQNdgclpaFPIWS---DVCSFDGRPWRGLVDVVSGGFPCQDISAAG 178
Cdd:cd00315    25 VAANEIDKSAAETY--EAN------FPNKLiegDITKIDEKDFIPDIDLLTGGFPCQPFSIAG 79
DUF1566 pfam07603
Protein of unknown function (DUF1566); These proteins of unknown function are found in ...
 44-77 9.08e-04

Protein of unknown function (DUF1566); These proteins of unknown function are found in Leptospira interrogans and in several gamma proteobacteria.


Pssm-ID: 429556 [Multi-domain]  Cd Length: 117  Bit Score: 37.36  E-value: 9.08e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 2786024015  44 PTQYSPNNAWNQNFDDGNQNNDHKDNQYRARAVR 77
Cdd:pfam07603  84 TSAGNPDYAWAVNFADGSVGYGNKSSGYYVRLVR 117
DNA_methylase pfam00145
C-5 cytosine-specific DNA methylase;
118-178 1.14e-03

C-5 cytosine-specific DNA methylase;


Pssm-ID: 395093 [Multi-domain]  Cd Length: 324  Bit Score: 38.45  E-value: 1.14e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2786024015 118 TICAVERDAYAAQVLaqRQNdgcLPAFPIwSDVCSFDGRPWRGlVDVVSGGFPCQDISAAG 178
Cdd:pfam00145  24 CVAANEIDKSAAKTY--EAN---FPKVPI-GDITLIDIKDIPD-IDILTGGFPCQDFSIAG 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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