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Conserved domains on  [gi|2787014724|ref|WP_370171857|]
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MULTISPECIES: flavodoxin family protein [Hyphomonas]

Protein Classification

flavodoxin family protein( domain architecture ID 10002025)

flavodoxin family protein is an electron-transfer flavoprotein, such as Methanosarcina thermophila iron-sulfur flavoprotein (Isf) and Clostridium saccharobutylicum flavodoxin, which are [4Fe-4S] cluster-binding electron-transfer flavoproteins

CATH:  3.40.50.360
Gene Ontology:  GO:0009055|GO:0010181
SCOP:  4003377

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WrbA COG0655
Multimeric flavodoxin WrbA, includes NAD(P)H:quinone oxidoreductase [Energy production and ...
 3-190 1.02e-37

Multimeric flavodoxin WrbA, includes NAD(P)H:quinone oxidoreductase [Energy production and conversion];


:

Pssm-ID: 440420 [Multi-domain]  Cd Length: 181  Bit Score: 128.51  E-value: 1.02e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787014724   3 KIAIVYHS--GYGHTAKVAEHVRKGAASTGAEVTLYKAEDL------ASPESGP----------WDELNAADGIIFGAPT 64
Cdd:COG0655     1 KILVINGSprKNGNTAALAEAVAEGAEEAGAEVELIRLADLdikpciGCGGTGKcvikddmnaiYEKLLEADGIIFGSPT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787014724  65 YMGSASAQMKQFLDATSKAWF-TDAWKDKIAAGFTNSGSlaGDKSSTLNQFSTIAAQHGMVWVNFglksgfnasghdfag 143
Cdd:COG0655    81 YFGNMSAQLKAFIDRLYALWAkGKLLKGKVGAVFTTGGH--GGAEATLLSLNTFLLHHGMIVVGL--------------- 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2787014724 144 alnraGFYNGLATQAMTDLSAEEGpdasdLKTAELFGERVANATLRW 190
Cdd:COG0655   144 -----PPYGAVGGGGPGDVLDEEG-----LATARELGKRLAELAKKL 180
 
Name Accession Description Interval E-value
WrbA COG0655
Multimeric flavodoxin WrbA, includes NAD(P)H:quinone oxidoreductase [Energy production and ...
 3-190 1.02e-37

Multimeric flavodoxin WrbA, includes NAD(P)H:quinone oxidoreductase [Energy production and conversion];


Pssm-ID: 440420 [Multi-domain]  Cd Length: 181  Bit Score: 128.51  E-value: 1.02e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787014724   3 KIAIVYHS--GYGHTAKVAEHVRKGAASTGAEVTLYKAEDL------ASPESGP----------WDELNAADGIIFGAPT 64
Cdd:COG0655     1 KILVINGSprKNGNTAALAEAVAEGAEEAGAEVELIRLADLdikpciGCGGTGKcvikddmnaiYEKLLEADGIIFGSPT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787014724  65 YMGSASAQMKQFLDATSKAWF-TDAWKDKIAAGFTNSGSlaGDKSSTLNQFSTIAAQHGMVWVNFglksgfnasghdfag 143
Cdd:COG0655    81 YFGNMSAQLKAFIDRLYALWAkGKLLKGKVGAVFTTGGH--GGAEATLLSLNTFLLHHGMIVVGL--------------- 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2787014724 144 alnraGFYNGLATQAMTDLSAEEGpdasdLKTAELFGERVANATLRW 190
Cdd:COG0655   144 -----PPYGAVGGGGPGDVLDEEG-----LATARELGKRLAELAKKL 180
PRK03767 PRK03767
NAD(P)H:quinone oxidoreductase; Provisional
 1-184 1.29e-27

NAD(P)H:quinone oxidoreductase; Provisional


Pssm-ID: 179647  Cd Length: 200  Bit Score: 103.08  E-value: 1.29e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787014724   1 MAKIAIVYHSGYGHTAKVAEHVRKGAAS-TGAEVTLYKA---------------EDLASPESGPwDELNAADGIIFGAPT 64
Cdd:PRK03767    1 MAKVLVLYYSMYGHIETMAEAVAEGAREvAGAEVTIKRVpetvpeevakkaggkTDQAAPVATP-DELADYDAIIFGTPT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787014724  65 YMGSASAQMKQFLDATSKAWFTDAWKDKIAAGFTNSGSLAGDKSSTLNQFSTIAAQHGMVWVnfGLksgfnasGHDFAGA 144
Cdd:PRK03767   80 RFGNMAGQMRNFLDQTGGLWAKGALVGKVGSVFTSTGTQHGGQETTITSTHTTLLHHGMVIV--GL-------PYAFQGQ 150

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2787014724 145 LN----RAGFYNGLATQAMTDLSAEegPDASDLKTAELFGERVA 184
Cdd:PRK03767  151 MDvdevTGGSPYGATTIAGGDGSRQ--PSENELAGARYQGRHVA 192
flav_wrbA TIGR01755
NAD(P)H:quinone oxidoreductase, type IV; This model represents a protein, WrbA, related to and ...
 2-184 5.66e-26

NAD(P)H:quinone oxidoreductase, type IV; This model represents a protein, WrbA, related to and slightly larger than flavodoxin. It was just shown, in E. coli and Archaeoglobus fulgidus (and previously for some eukaryotic homologs) to act as fourth type of NAD(P)H:quinone oxidoreductase. In E. coli, this protein was earlier reported to be produced during stationary phase, bind to the trp repressor, and make trp operon repression more efficient. WrbA does not interact with the trp operator by itself. Members are found in species in which homologs of the E. coli trp operon repressor TrpR (SP:P03032) are not detected. [Energy metabolism, Electron transport]


Pssm-ID: 130816 [Multi-domain]  Cd Length: 197  Bit Score: 98.81  E-value: 5.66e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787014724   2 AKIAIVYHSGYGHTAKVAEHVRKGAAST-GAEVTLYKAEDLASPE-----------SGPW---DELNAADGIIFGAPTYM 66
Cdd:TIGR01755   1 VKVLVLYYSMYGHIETMARAVAEGAREVdGAEVVVKRVPETVPEEvaekshgktdqTAPVatpQELADYDAIIFGTPTRF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787014724  67 GSASAQMKQFLDATSKAWFTDAWKDKIAAGFTNSGSLAGDKSSTLNQFSTIAAQHGMVWVNFGLksgfnASGHDFAGALN 146
Cdd:TIGR01755  81 GNMASQMRNFLDQTGGLWASGALVGKVGSVFTSTGTQHGGQESTILSTWTTLLHHGMIIVPLPY-----AAQEQMGVDEV 155

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2787014724 147 RAGFYNGLATQAMTDLSAEegPDASDLKTAELFGERVA 184
Cdd:TIGR01755 156 RGGSPYGATTIAGGDGSRQ--PSAEELDIARYQGRHVA 191
FMN_red pfam03358
NADPH-dependent FMN reductase;
13-124 4.63e-13

NADPH-dependent FMN reductase;


Pssm-ID: 427259 [Multi-domain]  Cd Length: 152  Bit Score: 63.80  E-value: 4.63e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787014724  13 GHTAKVAEHVRKgAASTGAEVTL----------YKAEDLASPESGPW-----DELNAADGIIFGAPTYMGSASAQMKQFL 77
Cdd:pfam03358  14 SNTRKLARWAAE-LLEEGAEVELidladlilplCDEDLEEEQGDPDDvqelrEKIAAADAIIIVTPEYNGSVSGLLKNAI 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2787014724  78 DATSKAWFTDAWKDKIAAGFTNSGSLAGdKSSTLNQFSTIAAQHGMV 124
Cdd:pfam03358  93 DWLSRLRGGKELRGKPVAIVSTGGGRSG-GLRAVEQLRQVLAELGAI 138
 
Name Accession Description Interval E-value
WrbA COG0655
Multimeric flavodoxin WrbA, includes NAD(P)H:quinone oxidoreductase [Energy production and ...
 3-190 1.02e-37

Multimeric flavodoxin WrbA, includes NAD(P)H:quinone oxidoreductase [Energy production and conversion];


Pssm-ID: 440420 [Multi-domain]  Cd Length: 181  Bit Score: 128.51  E-value: 1.02e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787014724   3 KIAIVYHS--GYGHTAKVAEHVRKGAASTGAEVTLYKAEDL------ASPESGP----------WDELNAADGIIFGAPT 64
Cdd:COG0655     1 KILVINGSprKNGNTAALAEAVAEGAEEAGAEVELIRLADLdikpciGCGGTGKcvikddmnaiYEKLLEADGIIFGSPT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787014724  65 YMGSASAQMKQFLDATSKAWF-TDAWKDKIAAGFTNSGSlaGDKSSTLNQFSTIAAQHGMVWVNFglksgfnasghdfag 143
Cdd:COG0655    81 YFGNMSAQLKAFIDRLYALWAkGKLLKGKVGAVFTTGGH--GGAEATLLSLNTFLLHHGMIVVGL--------------- 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2787014724 144 alnraGFYNGLATQAMTDLSAEEGpdasdLKTAELFGERVANATLRW 190
Cdd:COG0655   144 -----PPYGAVGGGGPGDVLDEEG-----LATARELGKRLAELAKKL 180
PRK03767 PRK03767
NAD(P)H:quinone oxidoreductase; Provisional
 1-184 1.29e-27

NAD(P)H:quinone oxidoreductase; Provisional


Pssm-ID: 179647  Cd Length: 200  Bit Score: 103.08  E-value: 1.29e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787014724   1 MAKIAIVYHSGYGHTAKVAEHVRKGAAS-TGAEVTLYKA---------------EDLASPESGPwDELNAADGIIFGAPT 64
Cdd:PRK03767    1 MAKVLVLYYSMYGHIETMAEAVAEGAREvAGAEVTIKRVpetvpeevakkaggkTDQAAPVATP-DELADYDAIIFGTPT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787014724  65 YMGSASAQMKQFLDATSKAWFTDAWKDKIAAGFTNSGSLAGDKSSTLNQFSTIAAQHGMVWVnfGLksgfnasGHDFAGA 144
Cdd:PRK03767   80 RFGNMAGQMRNFLDQTGGLWAKGALVGKVGSVFTSTGTQHGGQETTITSTHTTLLHHGMVIV--GL-------PYAFQGQ 150

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2787014724 145 LN----RAGFYNGLATQAMTDLSAEegPDASDLKTAELFGERVA 184
Cdd:PRK03767  151 MDvdevTGGSPYGATTIAGGDGSRQ--PSENELAGARYQGRHVA 192
flav_wrbA TIGR01755
NAD(P)H:quinone oxidoreductase, type IV; This model represents a protein, WrbA, related to and ...
 2-184 5.66e-26

NAD(P)H:quinone oxidoreductase, type IV; This model represents a protein, WrbA, related to and slightly larger than flavodoxin. It was just shown, in E. coli and Archaeoglobus fulgidus (and previously for some eukaryotic homologs) to act as fourth type of NAD(P)H:quinone oxidoreductase. In E. coli, this protein was earlier reported to be produced during stationary phase, bind to the trp repressor, and make trp operon repression more efficient. WrbA does not interact with the trp operator by itself. Members are found in species in which homologs of the E. coli trp operon repressor TrpR (SP:P03032) are not detected. [Energy metabolism, Electron transport]


Pssm-ID: 130816 [Multi-domain]  Cd Length: 197  Bit Score: 98.81  E-value: 5.66e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787014724   2 AKIAIVYHSGYGHTAKVAEHVRKGAAST-GAEVTLYKAEDLASPE-----------SGPW---DELNAADGIIFGAPTYM 66
Cdd:TIGR01755   1 VKVLVLYYSMYGHIETMARAVAEGAREVdGAEVVVKRVPETVPEEvaekshgktdqTAPVatpQELADYDAIIFGTPTRF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787014724  67 GSASAQMKQFLDATSKAWFTDAWKDKIAAGFTNSGSLAGDKSSTLNQFSTIAAQHGMVWVNFGLksgfnASGHDFAGALN 146
Cdd:TIGR01755  81 GNMASQMRNFLDQTGGLWASGALVGKVGSVFTSTGTQHGGQESTILSTWTTLLHHGMIIVPLPY-----AAQEQMGVDEV 155

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2787014724 147 RAGFYNGLATQAMTDLSAEegPDASDLKTAELFGERVA 184
Cdd:TIGR01755 156 RGGSPYGATTIAGGDGSRQ--PSAEELDIARYQGRHVA 191
FMN_red pfam03358
NADPH-dependent FMN reductase;
13-124 4.63e-13

NADPH-dependent FMN reductase;


Pssm-ID: 427259 [Multi-domain]  Cd Length: 152  Bit Score: 63.80  E-value: 4.63e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787014724  13 GHTAKVAEHVRKgAASTGAEVTL----------YKAEDLASPESGPW-----DELNAADGIIFGAPTYMGSASAQMKQFL 77
Cdd:pfam03358  14 SNTRKLARWAAE-LLEEGAEVELidladlilplCDEDLEEEQGDPDDvqelrEKIAAADAIIIVTPEYNGSVSGLLKNAI 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 2787014724  78 DATSKAWFTDAWKDKIAAGFTNSGSLAGdKSSTLNQFSTIAAQHGMV 124
Cdd:pfam03358  93 DWLSRLRGGKELRGKPVAIVSTGGGRSG-GLRAVEQLRQVLAELGAI 138
FldA COG0716
Flavodoxin [Energy production and conversion]; Flavodoxin is part of the Pathway/BioSystem: ...
 4-126 1.20e-12

Flavodoxin [Energy production and conversion]; Flavodoxin is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440480 [Multi-domain]  Cd Length: 135  Bit Score: 62.23  E-value: 1.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787014724   4 IAIVYHSGYGHTAKVAEHVRKGAASTGaeVTLYKAEDLaspesgPWDELNAADGIIFGAPTYMGSASAQMKQFLDAtska 83
Cdd:COG0716     1 ILIVYGSTTGNTEKVAEAIAEALGAAG--VDLFEIEDA------DLDDLEDYDLLILGTPTWAGELPDDWEDFLEE---- 68

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2787014724  84 wFTDAWKDKIAAGF-TNSGSLAGDkssTLNQFSTIAAQHGMVWV 126
Cdd:COG0716    69 -LKEDLSGKKVALFgTGDSSGYGD---ALGELKELLEEKGAKVV 108
NorV COG0426
Flavorubredoxin [Energy production and conversion];
3-101 5.23e-12

Flavorubredoxin [Energy production and conversion];


Pssm-ID: 440195 [Multi-domain]  Cd Length: 390  Bit Score: 63.31  E-value: 5.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787014724   3 KIAIVYHSGYGHTAKVAEHVRKGAASTGAEVTLYKAEdlASPESGPWDELNAADGIIFGAPTYMGSASAQMKQFLDATSK 82
Cdd:COG0426   248 KVVIVYASMYGNTEKMAEAIAEGLTEEGVKVKLYDLE--KTDPSEIITEIFDAKGIVIGSPTYNGGAFPPIADLLGYLKG 325

                          90
                  ....*....|....*....
gi 2787014724  83 AWFtdawKDKIAAGFTNSG 101
Cdd:COG0426   326 LAP----KNKLAGAFGSYG 340
HemG COG4635
Protoporphyrinogen IX oxidase, menaquinone-dependent (flavodoxin domain) [Coenzyme transport ...
 2-79 3.93e-10

Protoporphyrinogen IX oxidase, menaquinone-dependent (flavodoxin domain) [Coenzyme transport and metabolism];


Pssm-ID: 443673  Cd Length: 179  Bit Score: 56.44  E-value: 3.93e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2787014724   2 AKIAIVYHSGYGHTAKVAEHVRKGAASTGAEVTLYKAEDLASPesgpwdELNAADGIIFGAPTYMGSASAQMKQFLDA 79
Cdd:COG4635     1 MKVLILYASRDGQTRKIAERIAEVLREAGHDVDLVDLEDAPDL------DLAGYDAVVIGASIRYGKWLPEAVRFVRR 72
Flavodoxin_5 pfam12724
Flavodoxin domain; This is a family of flavodoxins. Flavodoxins are electron transfer proteins ...
 6-114 7.30e-08

Flavodoxin domain; This is a family of flavodoxins. Flavodoxins are electron transfer proteins that carry a molecule of non-covalently bound FMN.


Pssm-ID: 463681 [Multi-domain]  Cd Length: 144  Bit Score: 49.57  E-value: 7.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787014724   6 IVYHSGYGHTAKVAEHVrkgAASTGAEVTLYkaeDLASPESGPWdeLNAADGIIFGAPTYMGSASAQMKQFLDAtskawF 85
Cdd:pfam12724   2 ILYSSRDGQTKKIAERI---AEELREEGELV---DVEDVEAGED--LSSYDAVVIGASIYYGKHLPELRQFVTK-----H 68

                          90       100       110
                  ....*....|....*....|....*....|
gi 2787014724  86 TDAWKDKIAAGFTNSGSLAGD-KSSTLNQF 114
Cdd:pfam12724  69 RDELSSKPVAFFSVNLTARKPeKNPYMRKF 98
SsuE COG0431
NAD(P)H-dependent FMN reductase [Energy production and conversion];
15-105 1.26e-07

NAD(P)H-dependent FMN reductase [Energy production and conversion];


Pssm-ID: 440200 [Multi-domain]  Cd Length: 162  Bit Score: 49.00  E-value: 1.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787014724  15 TAKVAEHVRKGAASTGAEVTLYKAEDLASP------ESGPWDE--------LNAADGIIFGAPTYMGSASAQMKQFLDAT 80
Cdd:COG0431    16 NRKLARAAAELAPAAGAEVELIDLRDLDLPlydedlEADGAPPavkalreaIAAADGVVIVTPEYNGSYPGVLKNALDWL 95

                          90       100
                  ....*....|....*....|....*
gi 2787014724  81 SKawftDAWKDKIAAGFTNSGSLAG 105
Cdd:COG0431    96 SR----SELAGKPVALVSTSGGARG 116
PRK05569 PRK05569
flavodoxin; Provisional
 1-117 1.81e-07

flavodoxin; Provisional


Pssm-ID: 135442 [Multi-domain]  Cd Length: 141  Bit Score: 48.29  E-value: 1.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787014724   1 MAKIAIVYHSGYGHTAKVAEHVRKGAASTGAEVTLYKAEDlASPEsgpwDELNaADGIIFGAPTYMGSASAQ--MKQFLD 78
Cdd:PRK05569    1 MKKVSIIYWSCGGNVEVLANTIADGAKEAGAEVTIKHVAD-AKVE----DVLE-ADAVAFGSPSMDNNNIEQeeMAPFLD 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2787014724  79 A--------------TSKAW----FTDAWKDKIAA-GFTNSGSLAGDKSSTLNQFSTI 117
Cdd:PRK05569   75 QfkltpnenkkcilfGSYGWdngeFMKLWKDRMKDyGFNVIGDLAVNESPNKEELNSA 132
flav_short TIGR01753
flavodoxin, short chain; Flavodoxins are small redox-active proteins with a flavin ...
 4-65 5.12e-07

flavodoxin, short chain; Flavodoxins are small redox-active proteins with a flavin mononucleotide (FMN) prosthetic group. They can act in nitrogen fixation by nitrogenase, in sulfite reduction, and light-dependent NADP+ reduction in during photosynthesis, among other roles. This model describes the short chain type. Many of these are involved in sulfite reduction. [Energy metabolism, Electron transport]


Pssm-ID: 273789 [Multi-domain]  Cd Length: 140  Bit Score: 46.95  E-value: 5.12e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2787014724   4 IAIVYHSGYGHTAKVAEHVRKGAASTGAEVTLYKAEDlASPEsgpwdELNAADGIIFGAPTY 65
Cdd:TIGR01753   1 ILIVYASMTGNTEEMANIIAEGLKEAGAEVDLLEVAD-ADAE-----DLLSYDAVLLGCSTW 56
Flavodoxin_1 pfam00258
Flavodoxin;
6-78 6.13e-07

Flavodoxin;


Pssm-ID: 425562 [Multi-domain]  Cd Length: 142  Bit Score: 46.98  E-value: 6.13e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2787014724   6 IVYHSGYGHTAKVAEHVRKGAASTGAEVTLYKAEDLASpesgPWDELNAADGIIFGAPTYM-GSASAQMKQFLD 78
Cdd:pfam00258   1 IFYGSQTGNTEKLAEAIAEGLGEAGFEVDVVDLDDVDE----TLSEIEEEDLLLVVVSTWGeGEPPDNAKPFVD 70
PRK05568 PRK05568
flavodoxin; Provisional
 1-83 1.34e-06

flavodoxin; Provisional


Pssm-ID: 235508 [Multi-domain]  Cd Length: 142  Bit Score: 45.96  E-value: 1.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787014724   1 MAKIAIVYHSGYGHTAKVAEHVRKGAASTGAEVTLYKAEDLASpesgpwDELNAADGIIFGAPTyMGS---ASAQMKQFL 77
Cdd:PRK05568    1 MKKINIIYWSGTGNTEAMANLIAEGAKENGAEVKLLNVSEASV------DDVKGADVVALGSPA-MGDevlEEGEMEPFV 73


                  ....*.
gi 2787014724  78 DATSKA 83
Cdd:PRK05568   74 ESISSL 79
Flavodoxin_2 pfam02525
Flavodoxin-like fold; This family consists of a domain with a flavodoxin-like fold. The family ...
 3-78 2.24e-06

Flavodoxin-like fold; This family consists of a domain with a flavodoxin-like fold. The family includes bacterial and eukaryotic NAD(P)H dehydrogenase (quinone) EC:1.6.99.2. These enzymes catalyze the NAD(P)H-dependent two-electron reductions of quinones and protect cells against damage by free radicals and reactive oxygen species. This enzyme uses a FAD co-factor. The equation for this reaction is:- NAD(P)H + acceptor <=> NAD(P)(+) + reduced acceptor. This enzyme is also involved in the bioactivation of prodrugs used in chemotherapy. The family also includes acyl carrier protein phosphodiesterase EC:3.1.4.14. This enzyme converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine residue from ACP. This family is related to pfam03358 and pfam00258.


Pssm-ID: 426816 [Multi-domain]  Cd Length: 193  Bit Score: 46.17  E-value: 2.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787014724   3 KIAIVY-H-SGYGHTAKVAEHVRKGAASTGAEVT---LYK----------AEDLASPESGPW-----DELNAADGIIFGA 62
Cdd:pfam02525   2 KILIINaHpRPGSFSSRLADALVEALKAAGHEVTvrdLYAlflpvldaedLADLTYPQGAADveseqEELLAADVIVFQF 81

                          90
                  ....*....|....*.
gi 2787014724  63 PTYMGSASAQMKQFLD 78
Cdd:pfam02525  82 PLYWFSVPALLKGWID 97
PRK06756 PRK06756
flavodoxin; Provisional
 1-65 2.28e-05

flavodoxin; Provisional


Pssm-ID: 168663 [Multi-domain]  Cd Length: 148  Bit Score: 42.56  E-value: 2.28e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2787014724   1 MAKIAIVYHSGYGHTAKVAEHVRKGAASTGAEVTLYKAEDlaSPESgpwDELNAADGIIFGAPTY 65
Cdd:PRK06756    1 MSKLVMIFASMSGNTEEMADHIAGVIRETENEIEVIDIMD--SPEA---SILEQYDGIILGAYTW 60
MdaB COG2249
Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction ...
 3-78 2.86e-05

Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only];


Pssm-ID: 441850 [Multi-domain]  Cd Length: 190  Bit Score: 42.90  E-value: 2.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787014724   3 KIAIVYhsgyGH------TAKVAEHVRKGAASTGAEVT---LY--------KAEDLASPESGP------WDELNAADGII 59
Cdd:COG2249     1 KILIIY----AHpdpssfNAALAEAAAEGLEAAGHEVTvhdLYaegfdpvlSAADFYRDGPLPidvaaeQELLLWADHLV 76

                          90
                  ....*....|....*....
gi 2787014724  60 FGAPTYMGSASAQMKQFLD 78
Cdd:COG2249    77 FQFPLWWYSMPALLKGWID 95
PRK09267 PRK09267
flavodoxin FldA; Validated
 1-87 1.77e-03

flavodoxin FldA; Validated


Pssm-ID: 236439 [Multi-domain]  Cd Length: 169  Bit Score: 37.50  E-value: 1.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787014724   1 MAKIAIVYHSGYGHTAKVAEHVRKGAASTGAEVTlykaeDLASPESgpwDELNAADGIIFGAPTY-MGSASAQMKQFLDA 79
Cdd:PRK09267    1 MAKIGIFFGSDTGNTEDIAKMIQKKLGKDVADVV-----DIAKASK---EDFEAYDLLILGIPTWgYGELQCDWDDFLPE 72


                  ....*...
gi 2787014724  80 TSKAWFTD 87
Cdd:PRK09267   73 LEEIDFSG 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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