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Conserved domains on  [gi|2787122232|ref|WP_370271128|]
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dihydrofolate reductase [Muribaculum sp.]

Protein Classification

M49 family metallopeptidase( domain architecture ID 140806)

M49 family metallopeptidase contains a dipeptidylpeptidase similar to Rattus norvegicus dipeptidyl-peptidase III that binds a single zinc ion by means of two histidine ligands within an HEXXXH motif, and releases N-terminal dipeptides sequentially from a peptide

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Peptidase_M49 super family cl20254
Peptidase family M49;
209-638 1.51e-44

Peptidase family M49;


The actual alignment was detected with superfamily member pfam03571:

Pssm-ID: 460976  Cd Length: 550  Bit Score: 167.66  E-value: 1.51e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787122232 209 SYGLNTRKTKVNGKVVEQPYkvgGLYSPAIERIVSELNKAAEYAENPAQKAYIKKLVEFYTTGDLKAFDDYSIMWAEETD 288
Cdd:pfam03571  80 EYPEELETGEFNGKKVTLTY---GDHSPELKKIVENLEKAKKYAANDTQKKMLEKYIESFETGSIEAHKDSQRHWVKDKG 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787122232 289 SQVDFINGFIETYDDPLGMTGSWESIVNFKNNEASARTETLSKNAQWFESHSPIDPRFRKEEVKG---VSAKVITaaiLA 365
Cdd:pfam03571 157 PVVETNIGFIETYRDPAGVRGEFEGFVAIVNKERSAKFGKLVDNAEKFIPLLPWPKDFEKDKFLKpdfTSLEVLT---FA 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787122232 366 GDSYPAtpiGINLPNANWIRAAHGSKSVTLENITQAydeashgDGFNEEF-VIDEPTRKLLDDYLFITDNLHTDLHECLG 444
Cdd:pfam03571 234 GSGIPA---GINIPNYDDIRQNEGFKNVSLGNVLSA-------KAPNEKItFISEEDQELYKKYRDPAFEVQVGLHELLG 303

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787122232 445 HGSGRIL----PGV---DPDALK-----------------------AHGSTLEEARADLFALYYLADPKLIE-LGLLDSP 493
Cdd:pfam03571 304 HGSGKLLqetaDGKfnfDKENPPnpltgkpitswykpgetwgsvfgSLASSYEECRAECVALYLSLNKEVLEiFGFTDKE 383

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787122232 494 DAYKAEYYKYML---NGLM--------TQLMRiepgkdveEAHMRNRKLIAEWVLEHGKADNV-VEYVTIDGKT-YIRIN 560
Cdd:pfam03571 384 EADDVIYVNWLQmarAGLLalefydpeTKKWG--------QAHMQARFAILKVLLEAGDAGFVkLEETKDEDSDlTIRLD 455

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787122232 561 DYKRM---RELIGQLLGEIQRIKSEGDYEAGRNLVEKYAvKVDP---KIHDEVLKRYahlsiAPYKGFVNPvyNLVKDAN 634
Cdd:pfam03571 456 RSKILtvgKPAIGDFLLKLQVYKSTADVEAGTEFYEDYT-TVDEeflKWRDIVLAKK-----QPRKVFVQA--NTVLNDG 527


                  ....
gi 2787122232 635 GNVT 638
Cdd:pfam03571 528 GKVE 531
 
Name Accession Description Interval E-value
Peptidase_M49 pfam03571
Peptidase family M49;
209-638 1.51e-44

Peptidase family M49;


Pssm-ID: 460976  Cd Length: 550  Bit Score: 167.66  E-value: 1.51e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787122232 209 SYGLNTRKTKVNGKVVEQPYkvgGLYSPAIERIVSELNKAAEYAENPAQKAYIKKLVEFYTTGDLKAFDDYSIMWAEETD 288
Cdd:pfam03571  80 EYPEELETGEFNGKKVTLTY---GDHSPELKKIVENLEKAKKYAANDTQKKMLEKYIESFETGSIEAHKDSQRHWVKDKG 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787122232 289 SQVDFINGFIETYDDPLGMTGSWESIVNFKNNEASARTETLSKNAQWFESHSPIDPRFRKEEVKG---VSAKVITaaiLA 365
Cdd:pfam03571 157 PVVETNIGFIETYRDPAGVRGEFEGFVAIVNKERSAKFGKLVDNAEKFIPLLPWPKDFEKDKFLKpdfTSLEVLT---FA 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787122232 366 GDSYPAtpiGINLPNANWIRAAHGSKSVTLENITQAydeashgDGFNEEF-VIDEPTRKLLDDYLFITDNLHTDLHECLG 444
Cdd:pfam03571 234 GSGIPA---GINIPNYDDIRQNEGFKNVSLGNVLSA-------KAPNEKItFISEEDQELYKKYRDPAFEVQVGLHELLG 303

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787122232 445 HGSGRIL----PGV---DPDALK-----------------------AHGSTLEEARADLFALYYLADPKLIE-LGLLDSP 493
Cdd:pfam03571 304 HGSGKLLqetaDGKfnfDKENPPnpltgkpitswykpgetwgsvfgSLASSYEECRAECVALYLSLNKEVLEiFGFTDKE 383

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787122232 494 DAYKAEYYKYML---NGLM--------TQLMRiepgkdveEAHMRNRKLIAEWVLEHGKADNV-VEYVTIDGKT-YIRIN 560
Cdd:pfam03571 384 EADDVIYVNWLQmarAGLLalefydpeTKKWG--------QAHMQARFAILKVLLEAGDAGFVkLEETKDEDSDlTIRLD 455

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787122232 561 DYKRM---RELIGQLLGEIQRIKSEGDYEAGRNLVEKYAvKVDP---KIHDEVLKRYahlsiAPYKGFVNPvyNLVKDAN 634
Cdd:pfam03571 456 RSKILtvgKPAIGDFLLKLQVYKSTADVEAGTEFYEDYT-TVDEeflKWRDIVLAKK-----QPRKVFVQA--NTVLNDG 527


                  ....
gi 2787122232 635 GNVT 638
Cdd:pfam03571 528 GKVE 531
PLN02791 PLN02791
Nudix hydrolase homolog
 234-601 1.67e-26

Nudix hydrolase homolog


Pssm-ID: 215425 [Multi-domain]  Cd Length: 770  Bit Score: 115.30  E-value: 1.67e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787122232 234 YSPAIERIVSELNKAAEYAENPAQKAYIKKLVEFYTTGDlkaFDDYSIMWAEeTDSQVDFINGFIETYDDPL-GMTGSWE 312
Cdd:PLN02791  393 YKPFLKKAAELLHKAGDCADSPSLKRLLKSKAEAFLSND---YYESDIAWME-LDSKLDVTIGPYETYEDGLfGYKATFE 468

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787122232 313 SIVNFKNNEASARTETLSKNAQWFESHSPIDPRFRKEEVKGVSAKVITAAILAGDSYPATPIGINLPNANWIRAAHGSKS 392
Cdd:PLN02791  469 AFIGIRDDKATAQLKLFGDNLQTLEDNLPLDDVYKSTNVSAAPIRVIQLLYNSGDVKGPQTVAFNLPNDERIVKERGTSM 548

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787122232 393 VTLENITQAydEASHGDGFNEEFVIDEPTRKLLDDYLFITdnlHTDLHECLgHGSGR---ILPG-----VDPDALKAHgS 464
Cdd:PLN02791  549 VMLKNVSEA--KFKHILKPIAEVCISEEQKGYVDFESFFT---HTICHECC-HGIGPhtiTLPDgqkstVRLELQEVH-S 621

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787122232 465 TLEEARAD---LFALYYLADPKLIELGLLDSpdaykaeYYKYMLNGLMTQlmrIEPGkdVEEAHMRNRKLIAEWVLEHGK 541
Cdd:PLN02791  622 ALEEAKADivgLWALHFLIDKGLLSKSLEKS-------MYVSFLAGCFRS---IRFG--LEEAHGKGQALQFNWLYEKGA 689

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787122232 542 ADnvveyVTIDGKTYIrinDYKRMRELIGQLLGEIQRIKSEGDYEAGRNLVEKYAVKVDP 601
Cdd:PLN02791  690 FV-----LHSDGTFSV---DFAKVEDAVESLSREILTIQAKGDKAAAISLLQKYATLTPP 741
 
Name Accession Description Interval E-value
Peptidase_M49 pfam03571
Peptidase family M49;
209-638 1.51e-44

Peptidase family M49;


Pssm-ID: 460976  Cd Length: 550  Bit Score: 167.66  E-value: 1.51e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787122232 209 SYGLNTRKTKVNGKVVEQPYkvgGLYSPAIERIVSELNKAAEYAENPAQKAYIKKLVEFYTTGDLKAFDDYSIMWAEETD 288
Cdd:pfam03571  80 EYPEELETGEFNGKKVTLTY---GDHSPELKKIVENLEKAKKYAANDTQKKMLEKYIESFETGSIEAHKDSQRHWVKDKG 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787122232 289 SQVDFINGFIETYDDPLGMTGSWESIVNFKNNEASARTETLSKNAQWFESHSPIDPRFRKEEVKG---VSAKVITaaiLA 365
Cdd:pfam03571 157 PVVETNIGFIETYRDPAGVRGEFEGFVAIVNKERSAKFGKLVDNAEKFIPLLPWPKDFEKDKFLKpdfTSLEVLT---FA 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787122232 366 GDSYPAtpiGINLPNANWIRAAHGSKSVTLENITQAydeashgDGFNEEF-VIDEPTRKLLDDYLFITDNLHTDLHECLG 444
Cdd:pfam03571 234 GSGIPA---GINIPNYDDIRQNEGFKNVSLGNVLSA-------KAPNEKItFISEEDQELYKKYRDPAFEVQVGLHELLG 303

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787122232 445 HGSGRIL----PGV---DPDALK-----------------------AHGSTLEEARADLFALYYLADPKLIE-LGLLDSP 493
Cdd:pfam03571 304 HGSGKLLqetaDGKfnfDKENPPnpltgkpitswykpgetwgsvfgSLASSYEECRAECVALYLSLNKEVLEiFGFTDKE 383

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787122232 494 DAYKAEYYKYML---NGLM--------TQLMRiepgkdveEAHMRNRKLIAEWVLEHGKADNV-VEYVTIDGKT-YIRIN 560
Cdd:pfam03571 384 EADDVIYVNWLQmarAGLLalefydpeTKKWG--------QAHMQARFAILKVLLEAGDAGFVkLEETKDEDSDlTIRLD 455

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787122232 561 DYKRM---RELIGQLLGEIQRIKSEGDYEAGRNLVEKYAvKVDP---KIHDEVLKRYahlsiAPYKGFVNPvyNLVKDAN 634
Cdd:pfam03571 456 RSKILtvgKPAIGDFLLKLQVYKSTADVEAGTEFYEDYT-TVDEeflKWRDIVLAKK-----QPRKVFVQA--NTVLNDG 527


                  ....
gi 2787122232 635 GNVT 638
Cdd:pfam03571 528 GKVE 531
PLN02791 PLN02791
Nudix hydrolase homolog
 234-601 1.67e-26

Nudix hydrolase homolog


Pssm-ID: 215425 [Multi-domain]  Cd Length: 770  Bit Score: 115.30  E-value: 1.67e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787122232 234 YSPAIERIVSELNKAAEYAENPAQKAYIKKLVEFYTTGDlkaFDDYSIMWAEeTDSQVDFINGFIETYDDPL-GMTGSWE 312
Cdd:PLN02791  393 YKPFLKKAAELLHKAGDCADSPSLKRLLKSKAEAFLSND---YYESDIAWME-LDSKLDVTIGPYETYEDGLfGYKATFE 468

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787122232 313 SIVNFKNNEASARTETLSKNAQWFESHSPIDPRFRKEEVKGVSAKVITAAILAGDSYPATPIGINLPNANWIRAAHGSKS 392
Cdd:PLN02791  469 AFIGIRDDKATAQLKLFGDNLQTLEDNLPLDDVYKSTNVSAAPIRVIQLLYNSGDVKGPQTVAFNLPNDERIVKERGTSM 548

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787122232 393 VTLENITQAydEASHGDGFNEEFVIDEPTRKLLDDYLFITdnlHTDLHECLgHGSGR---ILPG-----VDPDALKAHgS 464
Cdd:PLN02791  549 VMLKNVSEA--KFKHILKPIAEVCISEEQKGYVDFESFFT---HTICHECC-HGIGPhtiTLPDgqkstVRLELQEVH-S 621

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787122232 465 TLEEARAD---LFALYYLADPKLIELGLLDSpdaykaeYYKYMLNGLMTQlmrIEPGkdVEEAHMRNRKLIAEWVLEHGK 541
Cdd:PLN02791  622 ALEEAKADivgLWALHFLIDKGLLSKSLEKS-------MYVSFLAGCFRS---IRFG--LEEAHGKGQALQFNWLYEKGA 689

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2787122232 542 ADnvveyVTIDGKTYIrinDYKRMRELIGQLLGEIQRIKSEGDYEAGRNLVEKYAVKVDP 601
Cdd:PLN02791  690 FV-----LHSDGTFSV---DFAKVEDAVESLSREILTIQAKGDKAAAISLLQKYATLTPP 741
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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