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Conserved domains on  [gi|2788623028|ref|WP_370582494|]
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carbohydrate ABC transporter permease [Plantibacter sp. VKM Ac-2880]

Protein Classification

carbohydrate ABC transporter permease( domain architecture ID 10003067)

carbohydrate ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter responsible for the translocation across the membrane of one or more from a variety of carbohydrate substrates including trehalose, lactose, arabinose, and maltodextrin

Gene Ontology:  GO:0042626|GO:0140359|GO:0008643|GO:0055085
PubMed:  25750732|24638992|30626703
TCDB:  3.A.1.1.-

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
52-321 7.11e-71

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


:

Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 221.93  E-value: 7.11e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028  52 WPLIRVVLFSLQDYGLreiVSGDTNFNGGANYAEVFADPTLWTVVLpNTVFFAAAAVIGTVVLGTLVALLMaNLGSFWRT 131
Cdd:COG1175    37 YPLLYTLYLSFTDWNL---LGPPPEFVGLDNYARLFTDPRFWNALG-NTLLFTVVSVPLQLVLGLLLALLL-NRKLRGRG 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 132 IVGSAIMVAWAMPAVTGTYVWVWIFDADRGIVNQTLMGAGLmdEPFNWFTNQFT-FYGIALLNVIHhGFPFVAITVLAGL 210
Cdd:COG1175   112 FFRTLFFLPWVISPVVVALIWKWLFNPDYGLLNALLGALGL--EPINWLGDPSLaLPAVIIVTVWK-GTGFNMLIFLAGL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 211 LGVSKEMLEAAEMDGAGAFRRFFQITFPSLRQVFSVVIILSTIWDFKVFAQIYLMPGGsGSNREVLNLGVWSYVESFGQN 290
Cdd:COG1175   189 QSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVYVLTGG-GPGNSTTTLVLYIYQTAFQQF 267

                         250       260       270
                  ....*....|....*....|....*....|.
gi 2788623028 291 RYGFGSAIAVLLTLVLLGITIVYIRALMKED 321
Cdd:COG1175   268 DFGYASAIAVVLFLIILVLTLLQLRLLRRRE 298
 
Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
52-321 7.11e-71

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 221.93  E-value: 7.11e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028  52 WPLIRVVLFSLQDYGLreiVSGDTNFNGGANYAEVFADPTLWTVVLpNTVFFAAAAVIGTVVLGTLVALLMaNLGSFWRT 131
Cdd:COG1175    37 YPLLYTLYLSFTDWNL---LGPPPEFVGLDNYARLFTDPRFWNALG-NTLLFTVVSVPLQLVLGLLLALLL-NRKLRGRG 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 132 IVGSAIMVAWAMPAVTGTYVWVWIFDADRGIVNQTLMGAGLmdEPFNWFTNQFT-FYGIALLNVIHhGFPFVAITVLAGL 210
Cdd:COG1175   112 FFRTLFFLPWVISPVVVALIWKWLFNPDYGLLNALLGALGL--EPINWLGDPSLaLPAVIIVTVWK-GTGFNMLIFLAGL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 211 LGVSKEMLEAAEMDGAGAFRRFFQITFPSLRQVFSVVIILSTIWDFKVFAQIYLMPGGsGSNREVLNLGVWSYVESFGQN 290
Cdd:COG1175   189 QSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVYVLTGG-GPGNSTTTLVLYIYQTAFQQF 267

                         250       260       270
                  ....*....|....*....|....*....|.
gi 2788623028 291 RYGFGSAIAVLLTLVLLGITIVYIRALMKED 321
Cdd:COG1175   268 DFGYASAIAVVLFLIILVLTLLQLRLLRRRE 298
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 97-307 3.02e-13

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 67.30  E-value: 3.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028  97 LPNTVFFAAAAVIGTVVLGTLVALLMANLGSFWRTIVGSAIMVAWAMPAVTGTYVWVWIFDADRGIvnqtlmgaglmdep 176
Cdd:cd06261     1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGW-------------- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 177 fnWFTNQFTFYGIALLNVIHhgFPFVAITVLAGLLGVSKEMLEAAEMDGAGAFRRFFQITFPSLRQVFSVVIILSTIWDF 256
Cdd:cd06261    67 --GILPGLGLPALILALLLI--APFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARAL 142

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2788623028 257 KVFAQIYLMpggSGSNREVLNLGVWSYVESFGQNRYGFGSAIAVLLTLVLL 307
Cdd:cd06261   143 GEFALVSFL---GGGEAPGPGTGLLLIFAILFPGDLGVAAAVALILLLLSL 190
malF PRK10999
maltose ABC transporter permease MalF;
73-316 2.30e-11

maltose ABC transporter permease MalF;


Pssm-ID: 236816 [Multi-domain]  Cd Length: 520  Bit Score: 64.21  E-value: 2.30e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028  73 GDTNFNGGANYAEVFADPTL---------WTVVlpntvfFAAAAVIGTVVLGTLVALLMAnlgsfWRTIVGSAI-----M 138
Cdd:PRK10999  260 GFTVTIGWKNFTRVFTDEGIqkpfiaifiWTVV------FSLLTVVLTVAVGMVLACLVQ-----WEALKGKAVyrvllI 328

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 139 VAWAMPAvtgtYVWVWIFdadRGIVNQT-----LMGAGLMDEPFNWFTNQFTFYGIALLNVIHHGFPFVAITVLAGLLGV 213
Cdd:PRK10999  329 LPYAVPS----FISILIF---KGLFNQSfgeinMMLSALFGIKPAWFSDPTLAKTMILIVNTWLGYPYMMILCMGLLKAI 401

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 214 SKEMLEAAEMDGAGAFRRFFQITFPSLRQVFSVVIILSTIWDFKVFAQIYLMPGGsGSNRevlnLG----------VWSY 283
Cdd:PRK10999  402 PDDLYEASAMDGAGPFQNFFKITLPLLIKPLTPLMIASFAFNFNNFVLIQLLTNG-GPDM----IGtttpagytdlLVSY 476

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 2788623028 284 V-----ESFGQNRYGFGSAIAVLLTLVLLGITIVYIRA 316
Cdd:PRK10999  477 TyriafEGGGGQDFGLAAAIATLIFLLVGALAILNLKA 514
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 70-304 4.46e-11

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 63.55  E-value: 4.46e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028  70 IVSGDTNFNGGANYAEVFADPTLWTVVLpNTVFFAAAAVIGTVVLGTLVALLMAN----LGSFWRTIVGSAIMVAWAMPA 145
Cdd:TIGR03262  30 VYDSDGDFIGLANFAEYFATPGLLQSLG-NSLTVSAIVTAIVVPLAFAFAYALTRsripGKGAFRLVALLPLLAPSLLPA 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 146 VTGTYVWvwifdADRGIVNQTLMGAGLmdepfnwftnqFTFYGIaLLNVIHHGFPFVAITVLAGLLGVSKEMLEAAEMDG 225
Cdd:TIGR03262 109 ISLIYLF-----GNQGLLKGLLGGFSI-----------YGFWGI-VIGEVFYTFPHALMILVTALSLADGRLYEAARAMG 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 226 AGAFRRFFQITFPSLRQ----VFSVVIILsTIWDFKVfaqiylmPGGSGSNREVLNLGVWSYVesFGQNRYGFGSAIAVL 301
Cdd:TIGR03262 172 ASPWRTFFTVTLPGAKYglisAAFVVFTL-VITDFGV-------PKVIGGDYNVLATDIYKQV--IGQQNFPMGAVVGVL 241


                  ...
gi 2788623028 302 LTL 304
Cdd:TIGR03262 242 LLL 244
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 197-309 2.13e-04

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 41.52  E-value: 2.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 197 HGFPFVAITVLAGLLGVSKEMLEAAEMDGAGAFRRFFQITFPSLRQVFSVVIILSTIWDFKVFAQIYLMPGGSGSNREVL 276
Cdd:pfam00528  62 GWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLI 141

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2788623028 277 nLGVWSYVESFGQNRYGFGSAIAVLLTLVLLGI 309
Cdd:pfam00528 142 -EAILGYDYPEIQGPVLAAALILLLLNLLVDIL 173
 
Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
52-321 7.11e-71

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 221.93  E-value: 7.11e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028  52 WPLIRVVLFSLQDYGLreiVSGDTNFNGGANYAEVFADPTLWTVVLpNTVFFAAAAVIGTVVLGTLVALLMaNLGSFWRT 131
Cdd:COG1175    37 YPLLYTLYLSFTDWNL---LGPPPEFVGLDNYARLFTDPRFWNALG-NTLLFTVVSVPLQLVLGLLLALLL-NRKLRGRG 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 132 IVGSAIMVAWAMPAVTGTYVWVWIFDADRGIVNQTLMGAGLmdEPFNWFTNQFT-FYGIALLNVIHhGFPFVAITVLAGL 210
Cdd:COG1175   112 FFRTLFFLPWVISPVVVALIWKWLFNPDYGLLNALLGALGL--EPINWLGDPSLaLPAVIIVTVWK-GTGFNMLIFLAGL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 211 LGVSKEMLEAAEMDGAGAFRRFFQITFPSLRQVFSVVIILSTIWDFKVFAQIYLMPGGsGSNREVLNLGVWSYVESFGQN 290
Cdd:COG1175   189 QSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVYVLTGG-GPGNSTTTLVLYIYQTAFQQF 267

                         250       260       270
                  ....*....|....*....|....*....|.
gi 2788623028 291 RYGFGSAIAVLLTLVLLGITIVYIRALMKED 321
Cdd:COG1175   268 DFGYASAIAVVLFLIILVLTLLQLRLLRRRE 298
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 52-323 7.27e-33

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 122.95  E-value: 7.27e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028  52 WPLIRVVLFSLQDYGLREIVSGDTNFnggANYAEVFADPTLWTVVLpNTVFFAAAAVIGTVVLGTLVALLMANLGSFWRT 131
Cdd:COG1176    28 LPLLLLLVYSFTTRDPYGGVVPGFTL---ENYARLFTDPLYLKVLL-RTLWIALLTTLICLLLGYPIAYFLARAPPRWRN 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 132 IVGSAIMVAWAMPAVTGTYVWVWIFdADRGIVNQTLMGAGLMDEPFNWFTNQFTFYgIALlnvIHHGFPFVAITVLAGLL 211
Cdd:COG1176   104 LLLLLVILPFWTSFLVRTYAWIVLL-GRNGLLNSLLLALGLIDEPLRLLYTEFAVV-IGL---VYVYLPFMVLPLYAALE 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 212 GVSKEMLEAAEMDGAGAFRRFFQITFPSLRQVFSVVIILSTIWDFKVFAQIYLMPGGSgsnreVLNLGVWSYVESFGQNR 291
Cdd:COG1176   179 KIDPSLLEAARDLGASPWQTFRRVILPLSLPGIIAGSLLVFIPALGAFVTPALLGGGK-----VLMIGNLIYQQFLSALN 253

                         250       260       270
                  ....*....|....*....|....*....|..
gi 2788623028 292 YGFGSAIAVLLTLVLLGITIVYIRALMKEDEL 323
Cdd:COG1176   254 WPLAAALAVVLLLIVLLVLLLYLRLLRRRRLL 285
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
52-317 5.11e-24

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 102.16  E-value: 5.11e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028  52 WPLIRVVLFSLQDyglreivsgdtnfnGGANYAEVFADPTLWTVVLpNTVFFAAAAVIGTVVLGTLVALLMANLGSFWRT 131
Cdd:COG1178    26 LPLLALLLRAFTD--------------GLANFWALLSDPYLWRALG-NTLLLALLVTLLSLLLGVPLAWLLARTDFPGRR 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 132 IVGSAIMVAWAMPAVTGTYVWVWIFDAdRGIVNQTLMgaglmdEPFNW-FTNQFTFYGIALLNVIHHgFPFVAITVLAGL 210
Cdd:COG1178    91 LLRWLLLLPLALPPYVVALAWIALFGP-NGLLNTLLR------ALFGLePPDIYGLGGIILVLVLFN-YPYVYLLLRAAL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 211 LGVSKEMLEAAEMDGAGAFRRFFQITFPSLRQVFSVVIILSTIWDFKVFAQIYLMpggsGSNREVLNLGVwsYVESFGQN 290
Cdd:COG1178   163 RSIDASLEEAARSLGASPWRAFRRVTLPLLRPAIAAGALLVFLLCLADFGTPLVL----GGGYTTLTTAI--YQAWLGDF 236

                         250       260
                  ....*....|....*....|....*..
gi 2788623028 291 RYGFGSAIAVLLTLVLLGITIVYIRAL 317
Cdd:COG1178   237 DLGAAAALALVLLLLVLLLLLLERRLR 263
LplB COG4209
ABC-type polysaccharide transport system, permease component [Carbohydrate transport and ...
 77-314 1.19e-19

ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 443357 [Multi-domain]  Cd Length: 316  Bit Score: 87.45  E-value: 1.19e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028  77 FNGGANYAEVFADPTLWTVVLpNTVFFAAAAVIGTVVLGTLVALLMANLGSFW--RTIVGSAIM---VAWampaVTGTYV 151
Cdd:COG4209    69 WVGLKNFKFLFSSPDFWRVLR-NTLLISLLKLVFGFPLPIILALLLNELRSKRfkKTVQTISYLphfLSW----VVVAGI 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 152 WVWIFDADRGIVNQTLMGAGLmdEPFNWFTNQFTFYGIALLNVIHHGFPFVAITVLAGLLGVSKEMLEAAEMDGAGAFRR 231
Cdd:COG4209   144 VYQFLSPDTGLVNQLLRALGG--EPINFLTEPKYFRPIYVFSGIWKEAGWGSIIYLAAITGIDPELYEAAAIDGAGRWQQ 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 232 FFQITFPSLRQVFSVVIILSTIWDFKV-FAQIYLMpgGSGSNREVLN-LGVWSYVESFGQNRYGFGSAIAVLLTLVllGI 309
Cdd:COG4209   222 IWHITLPGIRPTIVILLILNIGNILNVgFEQIYLL--YNPLNYSTSDvIDTYVYRIGLQNGDYSYATAVGLFKSVV--GL 297


                  ....*
gi 2788623028 310 TIVYI 314
Cdd:COG4209   298 ILVLI 302
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 81-314 1.94e-14

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 72.05  E-value: 1.94e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028  81 ANYAEVFADPTLWTVVLpNTVFFAAAAVIGTVVLGTLVALLMANLGSFWRTIVGSAIMVAWAMPAVTGTYVWVWIFDAdr 160
Cdd:COG0395    61 ENYRAAFTDGPFGRYLL-NSLIVAVVSTVLSLLLSSLAAYALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQ-- 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 161 givnqtlmgAGLMDepfnwftnqfTFYGIALLNVIHhGFPFVAITVLAGLLGVSKEMLEAAEMDGAGAFRRFFQITFPSL 240
Cdd:COG0395   138 ---------LGLLN----------TYWGLILPYLAF-GLPFGIFLLRQFFRSIPRELEEAARIDGASEFRIFWRIVLPLS 197

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2788623028 241 RQVFSVVIILSTIW---DFkVFAQIYLmpggSGSNREVLNLGVWSYVESFGQNrYGFGSAIAVLLTLVLLgitIVYI 314
Cdd:COG0395   198 KPALATVAIFTFIGawnDF-LWPLILL----TSPDLRTLPVGLASFQGQYGTD-WGLLMAAAVIATLPVL---ILFL 265
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 97-307 3.02e-13

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 67.30  E-value: 3.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028  97 LPNTVFFAAAAVIGTVVLGTLVALLMANLGSFWRTIVGSAIMVAWAMPAVTGTYVWVWIFDADRGIvnqtlmgaglmdep 176
Cdd:cd06261     1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGW-------------- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 177 fnWFTNQFTFYGIALLNVIHhgFPFVAITVLAGLLGVSKEMLEAAEMDGAGAFRRFFQITFPSLRQVFSVVIILSTIWDF 256
Cdd:cd06261    67 --GILPGLGLPALILALLLI--APFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARAL 142

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2788623028 257 KVFAQIYLMpggSGSNREVLNLGVWSYVESFGQNRYGFGSAIAVLLTLVLL 307
Cdd:cd06261   143 GEFALVSFL---GGGEAPGPGTGLLLIFAILFPGDLGVAAAVALILLLLSL 190
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
81-317 3.72e-13

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 69.80  E-value: 3.72e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028  81 ANYAEVFADPTLWTVVLpNTVFFAAAAVIGTVVLGTLVALLMANLGSFWRTIVGSAIMVAWAMPavtgtyvwvwifdadr 160
Cdd:COG1178   325 DNYRFVLLDPSLLRALL-NSLLLALLAALLAVLLALLLAYLVRRRRGRLARLLDRLAMLPYAVP---------------- 387

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 161 GIVnqtlMGAGLMdEPFNWFTNQFTFYGIALL---NVIHHgFPFVAITVLAGLLGVSKEMLEAAEMDGAGAFRRFFQITF 237
Cdd:COG1178   388 GIV----LGLGLL-LLFNRPLPLLLYGTLAILvlaYVVRF-LPFALRSLEAALAQIDPSLEEAARSLGASPLRTLRRVTL 461

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 238 PSLRQVFSVVIILSTIWDFKVFAQIYLMpggSGSNREVLNLGVWSYVESFgqnRYGFGSAIAVLLTLVLLGITIVYIRAL 317
Cdd:COG1178   462 PLLRPGLLAAALLVFVTSMKELSATLLL---RPPGFETLAVLIYQLASSG---RYGEAAALALLLVLVSLLPVLLLERLL 535
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 53-241 9.24e-13

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 67.06  E-value: 9.24e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028  53 PLIRVVLFSLQDYGLREIVSGDTNFNggaNYAEVFADPTLWTVVLpNTVFFAAAAVIGTVVLGTLVALLMANLGSFWRTI 132
Cdd:COG1177    23 PILVLVLYSFNDSWFLTFPPEGFTLR---WYAELFSDPRLLDALL-NSLLIALLSTLLATVLGTPAALALARYRFRGRRL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 133 VGSAIMVAWAMPAVtgtyvwvwifdadrgivnqtLMGAGLMDEpFNWFTNQFTFYGIALLNVIHhGFPFVAITVLAGLLG 212
Cdd:COG1177    99 LLALLLLPLVVPGI--------------------VLGVALLLL-FSALGLSGGLWGLILAHVVF-TLPFVVLVVLARLQG 156

                         170       180
                  ....*....|....*....|....*....
gi 2788623028 213 VSKEMLEAAEMDGAGAFRRFFQITFPSLR 241
Cdd:COG1177   157 FDPSLEEAARDLGASPWQTFRRVTLPLIA 185
malF PRK10999
maltose ABC transporter permease MalF;
73-316 2.30e-11

maltose ABC transporter permease MalF;


Pssm-ID: 236816 [Multi-domain]  Cd Length: 520  Bit Score: 64.21  E-value: 2.30e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028  73 GDTNFNGGANYAEVFADPTL---------WTVVlpntvfFAAAAVIGTVVLGTLVALLMAnlgsfWRTIVGSAI-----M 138
Cdd:PRK10999  260 GFTVTIGWKNFTRVFTDEGIqkpfiaifiWTVV------FSLLTVVLTVAVGMVLACLVQ-----WEALKGKAVyrvllI 328

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 139 VAWAMPAvtgtYVWVWIFdadRGIVNQT-----LMGAGLMDEPFNWFTNQFTFYGIALLNVIHHGFPFVAITVLAGLLGV 213
Cdd:PRK10999  329 LPYAVPS----FISILIF---KGLFNQSfgeinMMLSALFGIKPAWFSDPTLAKTMILIVNTWLGYPYMMILCMGLLKAI 401

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 214 SKEMLEAAEMDGAGAFRRFFQITFPSLRQVFSVVIILSTIWDFKVFAQIYLMPGGsGSNRevlnLG----------VWSY 283
Cdd:PRK10999  402 PDDLYEASAMDGAGPFQNFFKITLPLLIKPLTPLMIASFAFNFNNFVLIQLLTNG-GPDM----IGtttpagytdlLVSY 476

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 2788623028 284 V-----ESFGQNRYGFGSAIAVLLTLVLLGITIVYIRA 316
Cdd:PRK10999  477 TyriafEGGGGQDFGLAAAIATLIFLLVGALAILNLKA 514
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 70-304 4.46e-11

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 63.55  E-value: 4.46e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028  70 IVSGDTNFNGGANYAEVFADPTLWTVVLpNTVFFAAAAVIGTVVLGTLVALLMAN----LGSFWRTIVGSAIMVAWAMPA 145
Cdd:TIGR03262  30 VYDSDGDFIGLANFAEYFATPGLLQSLG-NSLTVSAIVTAIVVPLAFAFAYALTRsripGKGAFRLVALLPLLAPSLLPA 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 146 VTGTYVWvwifdADRGIVNQTLMGAGLmdepfnwftnqFTFYGIaLLNVIHHGFPFVAITVLAGLLGVSKEMLEAAEMDG 225
Cdd:TIGR03262 109 ISLIYLF-----GNQGLLKGLLGGFSI-----------YGFWGI-VIGEVFYTFPHALMILVTALSLADGRLYEAARAMG 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 226 AGAFRRFFQITFPSLRQ----VFSVVIILsTIWDFKVfaqiylmPGGSGSNREVLNLGVWSYVesFGQNRYGFGSAIAVL 301
Cdd:TIGR03262 172 ASPWRTFFTVTLPGAKYglisAAFVVFTL-VITDFGV-------PKVIGGDYNVLATDIYKQV--IGQQNFPMGAVVGVL 241


                  ...
gi 2788623028 302 LTL 304
Cdd:TIGR03262 242 LLL 244
PRK15050 PRK15050
2-aminoethylphosphonate transport system permease PhnU; Provisional
 7-238 1.98e-09

2-aminoethylphosphonate transport system permease PhnU; Provisional


Pssm-ID: 237888 [Multi-domain]  Cd Length: 296  Bit Score: 57.71  E-value: 1.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028   7 PPVTREAPASrvAGGPSPKRLRllmRTRPWLLLTPALLILAVLLLWPLIRVVLFSLqdyglreivSGDTNFnGGANYAEV 86
Cdd:PRK15050    1 AAARVRASAA--AHAAAARRRR---RLRPLLWLLLPLLVLAPLVVYPLVRVVLQSL---------TGEHGL-GLATYRAV 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028  87 FADPTLWTVVLpNTVFFAAAAVIGTVVLGTLVALLMANLGSFWRTIVGSAIMVAWAMPAVTGTYVWVWIFDAdRGIVNQT 166
Cdd:PRK15050   66 LGSPDFRGALL-TTLQIAFASTAGCLVLGVLLALVLAFVPFPGASLVGRFIDTFVAFPSFLITLAFTFLYGS-AGSVNIA 143

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2788623028 167 LMGA-GLMDEPFNWFtnqFTFYGIALLNVIHHGfPFVAITVLAGLLGVSKEMLEAAEMDGAGAFRRFFQITFP 238
Cdd:PRK15050  144 LQRLfGLEAPPLDFL---YSPGGVILAEITFYT-PFVVRPLLAAFAQLDARQLEAAASLGASPWRVARRVILP 212
PRK10561 PRK10561
sn-glycerol-3-phosphate ABC transporter permease UgpA;
52-315 2.31e-08

sn-glycerol-3-phosphate ABC transporter permease UgpA;


Pssm-ID: 182550 [Multi-domain]  Cd Length: 280  Bit Score: 54.45  E-value: 2.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028  52 WPLIRVVLFSLQD---YGLreivsgDTNFNGGANYAEVFADP----TLWTVVLpntvFFAAAAVIGTVVLGTLVALL--M 122
Cdd:PRK10561   16 WPAGEALWYSLQSvdpFGF------SSQFVGLDNFVALFHDSyyldSFWTTIK----FSTLVTVSGLLVSLFFAALVdyV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 123 ANLGSFWRTIVGSAIMVAWAMPAVtgtyVWVWIFDADRGIVNQTLMGAGlmdepFNWFTNQFT---FYGIALLNV---IH 196
Cdd:PRK10561   86 VRGSRFYQTLMLLPYAVAPAVAAV----LWIFLFNPGRGLITHFLAEFG-----YDWNHAQNSgqaMFLVVFASVwkqIS 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 197 HGFPFVaitvLAGLLGVSKEMLEAAEMDGAGAFRRFFQITFPSLRQVFSVVIILSTIWD-FKVFAQIYLMPGGsGSNREV 275
Cdd:PRK10561  157 YNFLFF----FAALQSIPRSLVEAAAIDGAGPIRRFFKLALPLIAPVSFFLLVVNLVYAfFDTFPVIDAATSG-GPVQAT 231

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2788623028 276 LNLGVWSYVESFGQNRYGFGSAIAVLLTLVLLGITIVYIR 315
Cdd:PRK10561  232 TTLIYKIYREGFTGLDLSSSAAQSVVLMFLVIVLTVVQFR 271
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 79-241 5.67e-08

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 52.83  E-value: 5.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028  79 GGANYAEVFADPTLWTVVLpNTVFFAAAAVIGTVVLGTLVALLMANLGSFWRTIVGSAIMVAWAMP-AVTGtyVWVWIFD 157
Cdd:COG0555    39 GWAEFWAVLTSPRVLAALK-LSLGTALIAALINLVFGLPLAWVLVRYRFPGKRLVDALVDLPFALPtAVAG--IALLLLF 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 158 ADRGIVNQTLMGAGlmdepfnwFTNQFTFYGI--ALLNVihhGFPFVAITVLAGLLGVSKEMLEAAEMDGAGAFRRFFQI 235
Cdd:COG0555   116 GPNGWLGQLLAPLG--------IKVAFTPLGIvlAQTFV---SLPFVVRTVQPVLEELDPELEEAAATLGASRWQTFRRV 184


                  ....*.
gi 2788623028 236 TFPSLR 241
Cdd:COG0555   185 ILPLLL 190
potB PRK09497
spermidine/putrescine ABC transporter membrane protein; Reviewed
 82-316 3.44e-07

spermidine/putrescine ABC transporter membrane protein; Reviewed


Pssm-ID: 181910  Cd Length: 285  Bit Score: 50.84  E-value: 3.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028  82 NYAEVFaDPTLWTVVLpNTVFFAAAAVIGTVVLGTLVALLMANLGSFWRTIVGSAIMVAWAMPAVTGTYvWVWIFDADRG 161
Cdd:PRK09497   52 NYTRLL-DPLYAEVLL-HSLNMALIATLACLVLGYPFAWFLAKLPHKVRPLLLFLLIVPFWTNSLIRIY-GLKIFLSTKG 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 162 IVNQTLMGAGLMDEPFNWFTNQFTfygiALLNVIHHGFPFVAITVLAGLLGVSKEMLEAAEMDGAGAFRRFFQITFPSLR 241
Cdd:PRK09497  129 YLNEFLLWLGVIDTPIRIMFTESA----VIIGLVYILLPFMVLPLYSSIEKLDKPLLEAARDLGANKLQTFIRIIIPLTM 204

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2788623028 242 QVFSVVIILSTIWDFKVFAQIYLMPGGsgsnrEVLNLGVWSYVESFGQNRYGFGSAIAVLLTLVLLGITIVYIRA 316
Cdd:PRK09497  205 PGIIAGCLLVLLPAMGMFYVSDLLGGA-----KNLLIGNVIKSQFLNIRDWPFGAATSITLTIVMGLMLLVYYRA 274
cysT CHL00187
sulfate transport protein; Provisional
 100-240 1.21e-04

sulfate transport protein; Provisional


Pssm-ID: 214388 [Multi-domain]  Cd Length: 237  Bit Score: 42.69  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 100 TVFFAAAAVIGTVVLGTLVALLMANLGSFWRTIVGSAIMVAWAMPAVTGTYVWVWIFdADRGIVNQTLMGAGLmdepfnw 179
Cdd:CHL00187   60 TLSMALIAALINGFFGLLIAWVLVRYNFPGKRLLDAAVDLPFALPTSVAGLTLATVY-GDNGWIGHLLSHLGI------- 131

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2788623028 180 fTNQFTFYGIaLLNVIHHGFPFVAITVLAGLLGVSKEMLEAAEMDGAGAFRRFFQITFPSL 240
Cdd:CHL00187  132 -QIVFTKLGV-LLAMIFVSFPFVVRTIQPVLQEIEKELEEAAWSLGASPWQTFWKVIFPPL 190
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 213-314 1.33e-04

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 42.83  E-value: 1.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 213 VSKEMLEAAEMDGAGAFRRFFQITFPSLRQVFSVVIILSTIW---DFkVFAQIYLmpgGSGSNReVLNLGVWSYVESFGQ 289
Cdd:COG3833   169 IPKELDEAAKIDGASHFQIFFRIILPLAKPILAVVALLSFIGpwnDF-ILASVLL---RSPENY-TLAVGLYSFVSDQRN 243

                          90       100
                  ....*....|....*....|....*
gi 2788623028 290 NRYGFGSAIAVlltLVLLGITIVYI 314
Cdd:COG3833   244 TNWGVFAAGAV---LVAIPIVILFL 265
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 197-309 2.13e-04

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 41.52  E-value: 2.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 197 HGFPFVAITVLAGLLGVSKEMLEAAEMDGAGAFRRFFQITFPSLRQVFSVVIILSTIWDFKVFAQIYLMPGGSGSNREVL 276
Cdd:pfam00528  62 GWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLI 141

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2788623028 277 nLGVWSYVESFGQNRYGFGSAIAVLLTLVLLGI 309
Cdd:pfam00528 142 -EAILGYDYPEIQGPVLAAALILLLLNLLVDIL 173
modB PRK09421
molybdate ABC transporter permease subunit;
104-238 7.18e-03

molybdate ABC transporter permease subunit;


Pssm-ID: 181841  Cd Length: 229  Bit Score: 37.21  E-value: 7.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2788623028 104 AAAAVIGTVVLGTLVALLMANlGSFW-RTIVGSAIMVAWAMPAVTGTYVWVWIFdADRGIVNQTLmgaglmdepFNWFTN 182
Cdd:PRK09421   18 SSVAVLFSLPFGILVAWLLAR-CRFPgKSLLDSLLHLPLVLPPVVTGYLLLISM-GRRGFIGQWL---------YEWFGI 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2788623028 183 QFTF--YGIALLNVIHhGFPFVAITVLAGLLGVSKEMLEAAEMDGAGAFRRFFQITFP 238
Cdd:PRK09421   87 SFAFswRGAALAAAVM-AFPLMVRAIRLSLEAVDRKLEQAARTLGASPWRVFFTITLP 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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