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Conserved domains on  [gi|2789491660|ref|WP_370811238|]
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AraC family transcriptional regulator [Anaerobutyricum hallii]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 13466276)

AraC family transcriptional regulator containing an AraC family helix-turn-helix (HTH) DNA-binding domain, may regulate the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  8831795|2644244|10473770|15808743|9409145|33837749|11282467
SCOP:  4000332

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
198-281 4.87e-23

helix_turn_helix, arabinose operon control protein;


:

Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 89.92  E-value: 4.87e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660  198 NININDYAASRGMSVSWFIRNFKKYTGSTPMQFIVGIRINNAQMLLETTTYSINEISKIVGYDNQLYFSRLFHKLKGYSP 277
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 2789491660  278 REYR 281
Cdd:smart00342  81 SEYR 84
PRK10572 super family cl35928
arabinose operon transcriptional regulator AraC;
42-284 1.07e-20

arabinose operon transcriptional regulator AraC;


The actual alignment was detected with superfamily member PRK10572:

Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 89.26  E-value: 1.07e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660  42 RPRGRLDYqIIYITA-GCGHFHfdNVNNEMIVPAGNIVLYRPKELQkyeYYGEDKTEVYWIH--------------FTGS 106
Cdd:PRK10572   43 RPLGMKGY-ILNLTIrGQGVIF--NGGRAFVCRPGDLLLFPPGEIH---HYGRHPDSDEWYHqwvyfrpraywadwLNWP 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660 107 NVKNILRQYGFPDkERVFQvgtsnEYEQIFKRIIiELQRCQDNY-EEMLVLLlrhllisFHRELTREHILKNEYLDHEMD 185
Cdd:PRK10572  117 SIFAGVGRLRIPD-EALQP-----EFSDLFGQIE-QAGQSEGRYsELLAMNL-------LERLLLRCMEAIPESLHPPMD 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660 186 ----NAVTFFSENYNQNININDYAASRGMSVSWFIRNFKKYTGSTPMQFIVGIRINNAQMLLETTTYSINEISKIVGYDN 261
Cdd:PRK10572  183 prvrEACQYISDHLASEFDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQTTRMPIATIGRNVGYDD 262

                         250       260
                  ....*....|....*....|...
gi 2789491660 262 QLYFSRLFHKLKGYSPREYRKLR 284
Cdd:PRK10572  263 QLYFSRVFKKCTGASPSEFRARC 285
 
Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
198-281 4.87e-23

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 89.92  E-value: 4.87e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660  198 NININDYAASRGMSVSWFIRNFKKYTGSTPMQFIVGIRINNAQMLLETTTYSINEISKIVGYDNQLYFSRLFHKLKGYSP 277
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 2789491660  278 REYR 281
Cdd:smart00342  81 SEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
199-286 7.33e-23

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 94.85  E-value: 7.33e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660 199 ININDYAASRGMSVSWFIRNFKKYTGSTPMQFIVGIRINNAQMLLETTTYSINEISKIVGYDNQLYFSRLFHKLKGYSPR 278
Cdd:COG2207   169 LTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPS 248


                  ....*...
gi 2789491660 279 EYRKLRNK 286
Cdd:COG2207   249 EYRKRLRA 256
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
42-284 1.07e-20

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 89.26  E-value: 1.07e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660  42 RPRGRLDYqIIYITA-GCGHFHfdNVNNEMIVPAGNIVLYRPKELQkyeYYGEDKTEVYWIH--------------FTGS 106
Cdd:PRK10572   43 RPLGMKGY-ILNLTIrGQGVIF--NGGRAFVCRPGDLLLFPPGEIH---HYGRHPDSDEWYHqwvyfrpraywadwLNWP 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660 107 NVKNILRQYGFPDkERVFQvgtsnEYEQIFKRIIiELQRCQDNY-EEMLVLLlrhllisFHRELTREHILKNEYLDHEMD 185
Cdd:PRK10572  117 SIFAGVGRLRIPD-EALQP-----EFSDLFGQIE-QAGQSEGRYsELLAMNL-------LERLLLRCMEAIPESLHPPMD 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660 186 ----NAVTFFSENYNQNININDYAASRGMSVSWFIRNFKKYTGSTPMQFIVGIRINNAQMLLETTTYSINEISKIVGYDN 261
Cdd:PRK10572  183 prvrEACQYISDHLASEFDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQTTRMPIATIGRNVGYDD 262

                         250       260
                  ....*....|....*....|...
gi 2789491660 262 QLYFSRLFHKLKGYSPREYRKLR 284
Cdd:PRK10572  263 QLYFSRVFKKCTGASPSEFRARC 285
HTH_18 pfam12833
Helix-turn-helix domain;
204-282 9.17e-20

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 81.48  E-value: 9.17e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660 204 YAASRGMSVSWFIRNFKKYTGSTPMQFIVGIRINNA-QMLLETTTYSINEISKIVGYDNQLYFSRLFHKLKGYSPREYRK 282
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERArRLLLEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80
PRK10371 PRK10371
transcriptional regulator MelR;
188-283 6.69e-13

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 67.54  E-value: 6.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660 188 VTFFSENYNQNININDYAASRGMSVSWFIRNFKKYTGSTPMQFIVGIRINNAQMLLETTTYSINEISKIVGYDNQLYFSR 267
Cdd:PRK10371  197 LGFIAENYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTDKSILDIALTAGFRSSSRFYS 276

                          90
                  ....*....|....*.
gi 2789491660 268 LFHKLKGYSPREYRKL 283
Cdd:PRK10371  277 TFGKYVGMSPQQYRKL 292
AraC_binding pfam02311
AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization ...
 28-145 1.11e-08

AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH) DNA-binding motif pfam00165. This domain is distantly related to the Cupin domain pfam00190.


Pssm-ID: 396749 [Multi-domain]  Cd Length: 134  Bit Score: 52.82  E-value: 1.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660  28 GTYRLSRHPKLPTYRPRGRLDYQIIYITAGCGHFHFDNvnNEMIVPAGNIVLYRPKELQKYEYYGEDKTEVYWIHFTGSN 107
Cdd:pfam02311   3 GLEGIEARYPGHSFPPHVHDFYVIGYIERGVGRFRLNG--RTYHLGPGDLFLLPPGEPHDYEPESEDGWRYRWLYFEPEL 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2789491660 108 VKNILRQYGFPDKERVFQVGTSnEYEQIFKRIIIELQR 145
Cdd:pfam02311  81 LERILADISILAGGPLPLLRDP-ELAALLRALFRLLEE 117
cupin_MmsR-like_N cd06986
AraC/XylS family transcriptional regulators similar to MmsR, N-terminal cupin domain; This ...
 19-106 1.69e-06

AraC/XylS family transcriptional regulators similar to MmsR, N-terminal cupin domain; This family contains bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included is MmsR, a bacterial transcriptional regulator thought to positively regulate the expression of the mmsAB operon. The mmsAB operon contains two structural genes involved in valine metabolism: mmsA which encodes methylmalonate-semialdehyde dehydrogenase, and mmsB which encodes 3-hydroxyisobutyrate dehydrogenase. The cupin domain of members of this subfamily does not contain a metal binding site.


Pssm-ID: 380391 [Multi-domain]  Cd Length: 84  Bit Score: 45.17  E-value: 1.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660  19 SRPLIVGSCGTY-RLSRHPklptYRPRGRLDYQIIYITAGCGHFHFDNVNNEmiVPAGNIVLYRPKELQkyeYYGEDKT- 96
Cdd:cd06986     2 SSDLYLTDCGYEpCEPGHS----YGPAVRDYYILHYVLSGKGTFSVNGKTYH--LKAGQGFLIPPGEPH---SYGADEDd 72

                          90
                  ....*....|..
gi 2789491660  97 --EVYWIHFTGS 106
Cdd:cd06986    73 pwTYYWIGFSGS 84
 
Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
198-281 4.87e-23

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 89.92  E-value: 4.87e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660  198 NININDYAASRGMSVSWFIRNFKKYTGSTPMQFIVGIRINNAQMLLETTTYSINEISKIVGYDNQLYFSRLFHKLKGYSP 277
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 2789491660  278 REYR 281
Cdd:smart00342  81 SEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
199-286 7.33e-23

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 94.85  E-value: 7.33e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660 199 ININDYAASRGMSVSWFIRNFKKYTGSTPMQFIVGIRINNAQMLLETTTYSINEISKIVGYDNQLYFSRLFHKLKGYSPR 278
Cdd:COG2207   169 LTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPS 248


                  ....*...
gi 2789491660 279 EYRKLRNK 286
Cdd:COG2207   249 EYRKRLRA 256
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 187-282 6.39e-21

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 90.22  E-value: 6.39e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660 187 AVTFFSENYNQNININDYAASRGMSVSWFIRNFKKYTGSTPMQFIVGIRINNAQMLLETTTYSINEISKIVGYDNQLYFS 266
Cdd:COG4977   215 AQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGSASHFR 294

                          90
                  ....*....|....*.
gi 2789491660 267 RLFHKLKGYSPREYRK 282
Cdd:COG4977   295 RAFRRRFGVSPSAYRR 310
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
42-284 1.07e-20

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 89.26  E-value: 1.07e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660  42 RPRGRLDYqIIYITA-GCGHFHfdNVNNEMIVPAGNIVLYRPKELQkyeYYGEDKTEVYWIH--------------FTGS 106
Cdd:PRK10572   43 RPLGMKGY-ILNLTIrGQGVIF--NGGRAFVCRPGDLLLFPPGEIH---HYGRHPDSDEWYHqwvyfrpraywadwLNWP 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660 107 NVKNILRQYGFPDkERVFQvgtsnEYEQIFKRIIiELQRCQDNY-EEMLVLLlrhllisFHRELTREHILKNEYLDHEMD 185
Cdd:PRK10572  117 SIFAGVGRLRIPD-EALQP-----EFSDLFGQIE-QAGQSEGRYsELLAMNL-------LERLLLRCMEAIPESLHPPMD 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660 186 ----NAVTFFSENYNQNININDYAASRGMSVSWFIRNFKKYTGSTPMQFIVGIRINNAQMLLETTTYSINEISKIVGYDN 261
Cdd:PRK10572  183 prvrEACQYISDHLASEFDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQTTRMPIATIGRNVGYDD 262

                         250       260
                  ....*....|....*....|...
gi 2789491660 262 QLYFSRLFHKLKGYSPREYRKLR 284
Cdd:PRK10572  263 QLYFSRVFKKCTGASPSEFRARC 285
HTH_18 pfam12833
Helix-turn-helix domain;
204-282 9.17e-20

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 81.48  E-value: 9.17e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660 204 YAASRGMSVSWFIRNFKKYTGSTPMQFIVGIRINNA-QMLLETTTYSINEISKIVGYDNQLYFSRLFHKLKGYSPREYRK 282
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERArRLLLEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80
PRK10371 PRK10371
transcriptional regulator MelR;
188-283 6.69e-13

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 67.54  E-value: 6.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660 188 VTFFSENYNQNININDYAASRGMSVSWFIRNFKKYTGSTPMQFIVGIRINNAQMLLETTTYSINEISKIVGYDNQLYFSR 267
Cdd:PRK10371  197 LGFIAENYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTDKSILDIALTAGFRSSSRFYS 276

                          90
                  ....*....|....*.
gi 2789491660 268 LFHKLKGYSPREYRKL 283
Cdd:PRK10371  277 TFGKYVGMSPQQYRKL 292
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 187-284 1.01e-10

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 61.61  E-value: 1.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660 187 AVTFFSENYNQNININDYAASRGMSVSWFIRNFKKYTGSTPMQFIVGIRINNAQMLLETTTySINEISKIVGYDNQLYFS 266
Cdd:COG2169    89 ACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQTGL-SVTDAAYAAGFGSLSRFY 167

                          90
                  ....*....|....*...
gi 2789491660 267 RLFHKLKGYSPREYRKLR 284
Cdd:COG2169   168 EAFKKLLGMTPSAYRRGG 185
ftrA PRK09393
transcriptional activator FtrA; Provisional
 193-282 1.84e-10

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 60.36  E-value: 1.84e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660 193 ENYNQNININDYAASRGMSVSWFIRNFKKYTGSTPMQFIVGIRINNAQMLLETTTYSINEISKIVGYDNQLYFSRLFHKL 272
Cdd:PRK09393  229 AHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSALSIDQIAERAGFGSEESLRHHFRRR 308

                          90
                  ....*....|
gi 2789491660 273 KGYSPREYRK 282
Cdd:PRK09393  309 AATSPAAYRK 318
PRK10296 PRK10296
DNA-binding transcriptional regulator ChbR; Provisional
 209-282 1.87e-09

DNA-binding transcriptional regulator ChbR; Provisional


Pssm-ID: 182362 [Multi-domain]  Cd Length: 278  Bit Score: 57.07  E-value: 1.87e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2789491660 209 GMSVSWFIRNFKKYTGSTPMQFIVGIRINNAQMLLETTTYSINEISKIVGYDNQLYFSRLFHKLKGYSPREYRK 282
Cdd:PRK10296  199 GKSQEYLTRATRRYYGKTPMQIINEIRINFAKKQLEMTNYSVTDIAFEAGYSSPSLFIKTFKKLTSFTPGSYRK 272
AraC_binding pfam02311
AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization ...
 28-145 1.11e-08

AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH) DNA-binding motif pfam00165. This domain is distantly related to the Cupin domain pfam00190.


Pssm-ID: 396749 [Multi-domain]  Cd Length: 134  Bit Score: 52.82  E-value: 1.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660  28 GTYRLSRHPKLPTYRPRGRLDYQIIYITAGCGHFHFDNvnNEMIVPAGNIVLYRPKELQKYEYYGEDKTEVYWIHFTGSN 107
Cdd:pfam02311   3 GLEGIEARYPGHSFPPHVHDFYVIGYIERGVGRFRLNG--RTYHLGPGDLFLLPPGEPHDYEPESEDGWRYRWLYFEPEL 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 2789491660 108 VKNILRQYGFPDKERVFQVGTSnEYEQIFKRIIIELQR 145
Cdd:pfam02311  81 LERILADISILAGGPLPLLRDP-ELAALLRALFRLLEE 117
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
217-286 3.26e-07

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 50.44  E-value: 3.26e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660 217 RNFKKYTGSTPMQFIVGIRINNAQMLLETTTYSINEISKIVGYDNQLYFSRLFHKLKGYSPREYRKLRNK 286
Cdd:PRK13502  211 QQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVFTRETGMTPSQWRHLSNQ 280
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
219-282 4.94e-07

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 49.90  E-value: 4.94e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2789491660 219 FKKYTGSTPMQFIVGIRINNAQMLLETTTYSINEISKIVGYDNQLYFSRLFHKLKGYSPREYRK 282
Cdd:PRK13501  213 FRQQTGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFSAVFTREAGMTPRDYRQ 276
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
193-281 1.05e-06

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 46.46  E-value: 1.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660 193 ENYNQNININDYAASRGMSVSWFIRNFKKYTGSTPMQFIVGIRINNAQMLLETTTYSINEISKIVGYDNQLYFSRLFHKL 272
Cdd:PRK10219   16 EHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVFRRQ 95


                  ....*....
gi 2789491660 273 KGYSPREYR 281
Cdd:PRK10219   96 FDRTPSDYR 104
cupin_MmsR-like_N cd06986
AraC/XylS family transcriptional regulators similar to MmsR, N-terminal cupin domain; This ...
 19-106 1.69e-06

AraC/XylS family transcriptional regulators similar to MmsR, N-terminal cupin domain; This family contains bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included is MmsR, a bacterial transcriptional regulator thought to positively regulate the expression of the mmsAB operon. The mmsAB operon contains two structural genes involved in valine metabolism: mmsA which encodes methylmalonate-semialdehyde dehydrogenase, and mmsB which encodes 3-hydroxyisobutyrate dehydrogenase. The cupin domain of members of this subfamily does not contain a metal binding site.


Pssm-ID: 380391 [Multi-domain]  Cd Length: 84  Bit Score: 45.17  E-value: 1.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660  19 SRPLIVGSCGTY-RLSRHPklptYRPRGRLDYQIIYITAGCGHFHFDNVNNEmiVPAGNIVLYRPKELQkyeYYGEDKT- 96
Cdd:cd06986     2 SSDLYLTDCGYEpCEPGHS----YGPAVRDYYILHYVLSGKGTFSVNGKTYH--LKAGQGFLIPPGEPH---SYGADEDd 72

                          90
                  ....*....|..
gi 2789491660  97 --EVYWIHFTGS 106
Cdd:cd06986    73 pwTYYWIGFSGS 84
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
193-284 2.66e-06

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 47.75  E-value: 2.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660 193 ENYNQNININDYAASRGMSVSWFIRNFKKYTGSTPMQFIVGIRINNAQMLLETTTYSINEISKIVGYDNQLYFSRLFHKL 272
Cdd:PRK13503  182 DHFAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRHSDASVTDIAYRCGFGDSNHFSTLFRRE 261

                          90
                  ....*....|..
gi 2789491660 273 KGYSPREYRKLR 284
Cdd:PRK13503  262 FSWSPRDIRQGR 273
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 193-231 1.83e-05

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 40.99  E-value: 1.83e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2789491660 193 ENYNQNININDYAASRGMSVSWFIRNFKKYTGSTPMQFI 231
Cdd:pfam00165   3 ENLSTNLTIADIADELGFSRSYFSRLFKKYTGVTPSQYR 41
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 244-282 2.86e-04

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 37.52  E-value: 2.86e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2789491660 244 ETTTYSINEISKIVGYDnQLYFSRLFHKLKGYSPREYRK 282
Cdd:pfam00165   5 LSTNLTIADIADELGFS-RSYFSRLFKKYTGVTPSQYRH 42
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 164-280 1.96e-03

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 39.28  E-value: 1.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660 164 SFHRELTREHILKNEYldhemdnavTFFSENYNQNININDYAASRGMSVSWFIRNFKKYTGSTPmQFIVGIRINNAQMLL 243
Cdd:PRK15186  172 ALFRELSQNTLAENIY---------NIIISDISRKWALKDISDSLYMSCSTLKRKLKQENTSFS-EVYLNARMNKATKLL 241

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2789491660 244 ETTTYSINEISKIVGYDNQLYFSRLFHKLKGYSPREY 280
Cdd:PRK15186  242 RNSEYNITRVAYMCGYDSASYFTCVFKKHFKTTPSEF 278
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 201-285 2.72e-03

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 38.82  E-value: 2.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2789491660 201 INDYAASRGMSVSWFIRNFKKyTGSTPMQFIVGIRINNAQMLLETTTYSINEISKIVGYDNQLYFSRLFHKLKGYSPREY 280
Cdd:PRK15185  225 LTDVADHIFMSTSTLKRKLAE-EGTSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTPSTF 303


                  ....*
gi 2789491660 281 RKLRN 285
Cdd:PRK15185  304 IKMAN 308
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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