NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2791440095|ref|WP_371441152|]
View 

CRISPR-associated endonuclease Cas2 [Corynebacterium sp. HMSC061H03]

Protein Classification

CRISPR-associated endonuclease Cas2( domain architecture ID 10176714)

CRISPR-associated endonuclease Cas2 plays an essential part in the adaptation stage of CRISPR-Cas systems

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Cas2_I_II_III cd09725
CRISPR/Cas system-associated protein Cas2; CRISPR (Clustered Regularly Interspaced Short ...
 39-98 1.54e-23

CRISPR/Cas system-associated protein Cas2; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold


:

Pssm-ID: 187856  Cd Length: 79  Bit Score: 86.77  E-value: 1.54e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791440095  39 IIAYDIQNDRRRTKVAKTLESYGDRVQYSVFVIDIHPAALLRLKGEVRKIINDREDSILF 98
Cdd:cd09725     2 IVVYDISDDKRRNKVAKLLKKYLQRVQNSVFEGELTEAQLKKLKAELKKIIDPEEDSVRI 61
 
Name Accession Description Interval E-value
Cas2_I_II_III cd09725
CRISPR/Cas system-associated protein Cas2; CRISPR (Clustered Regularly Interspaced Short ...
 39-98 1.54e-23

CRISPR/Cas system-associated protein Cas2; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold


Pssm-ID: 187856  Cd Length: 79  Bit Score: 86.77  E-value: 1.54e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791440095  39 IIAYDIQNDRRRTKVAKTLESYGDRVQYSVFVIDIHPAALLRLKGEVRKIINDREDSILF 98
Cdd:cd09725     2 IVVYDISDDKRRNKVAKLLKKYLQRVQNSVFEGELTEAQLKKLKAELKKIIDPEEDSVRI 61
Cas2 COG1343
CRISPR/Cas system-associated endoribonuclease Cas2 [Defense mechanisms]; CRISPR/Cas ...
 37-102 2.76e-22

CRISPR/Cas system-associated endoribonuclease Cas2 [Defense mechanisms]; CRISPR/Cas system-associated endoribonuclease Cas2 is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 440954  Cd Length: 89  Bit Score: 83.72  E-value: 2.76e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2791440095  37 RTIIAYDIQNDRRRTKVAKTLESYGDRVQYSVFVIDIHPAALLRLKGEVRKIINDREDSILFCDLG 102
Cdd:COG1343     2 WVLVVYDIPDDKRRRKVAKLLKKYGFRVQYSVFEGELTEAELAELKKRLKKIIDPEEDSVRIYPLT 67
CRISPR_Cas2 pfam09827
CRISPR associated protein Cas2; This entry represents members of the family of Cas2, one of ...
 37-102 1.19e-21

CRISPR associated protein Cas2; This entry represents members of the family of Cas2, one of the first four protein families found to be associated with prokaryotic genomes containing multiple CRISPR elements. CRISPR systems protect against invasive nucleic acid sequences, including phage. Cas2 proteins have been characterized as either endoribonuclease (for ssRNA) or endodeoxyribonuclease (for dsDNA), depending on the system to which the Cas2 belongs. The cas genes usually are found near the palindromic repeats. The structural subunit of Cas2, belongs to the VapD family of interferases. The interferase catalytic site is intact in the majority of the Cas2 proteins but is disrupted in some, and is not required for spacer acquisition. This entry also includes the endoribonuclease VapD.


Pssm-ID: 462916  Cd Length: 72  Bit Score: 81.76  E-value: 1.19e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2791440095  37 RTIIAYDIQNDRRRTKVAKTLESYGDRVQYSVFVIDIHPAALLRLKGEVRKIINDREDSILFCDLG 102
Cdd:pfam09827   2 YVLVVYDISDRKRRRKVAKILKKYFQRVQNSVFEGELSEAQAEKLKKRLKKIIDPEEDSIRIYPLT 67
cas2 TIGR01573
CRISPR-associated endonuclease Cas2; This model describes most members of the family of Cas2, ...
 36-96 1.72e-08

CRISPR-associated endonuclease Cas2; This model describes most members of the family of Cas2, one of the first four protein families found to mark prokaryotic genomes that contain multiple CRISPR elements. CRISPR systems protect against invasive nucleic acid sequences, including phage. Cas2 proteins have been characterized as either endoribonuclease (for ssRNA) or endodeoxyribonuclease (for dsDNA), depending on the system to which the Cas2 belongs. CRISPR is an acronym for Clustered Regularly Interspaced Short Palindromic Repeats. The cas genes usually are found near the repeats. A distinct branch of the Cas2 family shows a very low level of sequence identity and is modeled by TIGR01873 instead of by this model (TIGR01573).


Pssm-ID: 273699  Cd Length: 95  Bit Score: 48.51  E-value: 1.72e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2791440095  36 RRTIIAYDIQND---RRRTKVAKTLESYGD-RVQYSVFVIDIHPAALLR-LKGEVRKIINDrEDSI 96
Cdd:TIGR01573   1 MLVLVVYDIPTDgerKRRRKLRKLLEKYGLqRVQYSVFEGILEPNQLARkLIERLKRIIPD-EGSI 65
 
Name Accession Description Interval E-value
Cas2_I_II_III cd09725
CRISPR/Cas system-associated protein Cas2; CRISPR (Clustered Regularly Interspaced Short ...
 39-98 1.54e-23

CRISPR/Cas system-associated protein Cas2; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold


Pssm-ID: 187856  Cd Length: 79  Bit Score: 86.77  E-value: 1.54e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791440095  39 IIAYDIQNDRRRTKVAKTLESYGDRVQYSVFVIDIHPAALLRLKGEVRKIINDREDSILF 98
Cdd:cd09725     2 IVVYDISDDKRRNKVAKLLKKYLQRVQNSVFEGELTEAQLKKLKAELKKIIDPEEDSVRI 61
Cas2 COG1343
CRISPR/Cas system-associated endoribonuclease Cas2 [Defense mechanisms]; CRISPR/Cas ...
 37-102 2.76e-22

CRISPR/Cas system-associated endoribonuclease Cas2 [Defense mechanisms]; CRISPR/Cas system-associated endoribonuclease Cas2 is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 440954  Cd Length: 89  Bit Score: 83.72  E-value: 2.76e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2791440095  37 RTIIAYDIQNDRRRTKVAKTLESYGDRVQYSVFVIDIHPAALLRLKGEVRKIINDREDSILFCDLG 102
Cdd:COG1343     2 WVLVVYDIPDDKRRRKVAKLLKKYGFRVQYSVFEGELTEAELAELKKRLKKIIDPEEDSVRIYPLT 67
CRISPR_Cas2 pfam09827
CRISPR associated protein Cas2; This entry represents members of the family of Cas2, one of ...
 37-102 1.19e-21

CRISPR associated protein Cas2; This entry represents members of the family of Cas2, one of the first four protein families found to be associated with prokaryotic genomes containing multiple CRISPR elements. CRISPR systems protect against invasive nucleic acid sequences, including phage. Cas2 proteins have been characterized as either endoribonuclease (for ssRNA) or endodeoxyribonuclease (for dsDNA), depending on the system to which the Cas2 belongs. The cas genes usually are found near the palindromic repeats. The structural subunit of Cas2, belongs to the VapD family of interferases. The interferase catalytic site is intact in the majority of the Cas2 proteins but is disrupted in some, and is not required for spacer acquisition. This entry also includes the endoribonuclease VapD.


Pssm-ID: 462916  Cd Length: 72  Bit Score: 81.76  E-value: 1.19e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2791440095  37 RTIIAYDIQNDRRRTKVAKTLESYGDRVQYSVFVIDIHPAALLRLKGEVRKIINDREDSILFCDLG 102
Cdd:pfam09827   2 YVLVVYDISDRKRRRKVAKILKKYFQRVQNSVFEGELSEAQAEKLKKRLKKIIDPEEDSIRIYPLT 67
Cas2_I_II_III cd09638
CRISPR/Cas system-associated protein Cas2; CRISPR (Clustered Regularly Interspaced Short ...
 36-96 1.34e-10

CRISPR/Cas system-associated protein Cas2; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas2 is present in majority of CRISPR/Cas systems along with Cas1; RNAse specific to U-rich regions; Possesses an RRM/ferredoxin fold


Pssm-ID: 187769  Cd Length: 90  Bit Score: 53.92  E-value: 1.34e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2791440095  36 RRTIIAYDIQND---RRRTKVAKTLESYG-DRVQYSVFVIDIHPAALLRLKGEVRKIINDrEDSI 96
Cdd:cd09638     1 MLVLVVYDIPEDterKRRRKLRKLLEKYGlFRVQYSVFEGILEPNLLASLIERLKKIIPD-EDSI 64
cas2 TIGR01573
CRISPR-associated endonuclease Cas2; This model describes most members of the family of Cas2, ...
 36-96 1.72e-08

CRISPR-associated endonuclease Cas2; This model describes most members of the family of Cas2, one of the first four protein families found to mark prokaryotic genomes that contain multiple CRISPR elements. CRISPR systems protect against invasive nucleic acid sequences, including phage. Cas2 proteins have been characterized as either endoribonuclease (for ssRNA) or endodeoxyribonuclease (for dsDNA), depending on the system to which the Cas2 belongs. CRISPR is an acronym for Clustered Regularly Interspaced Short Palindromic Repeats. The cas genes usually are found near the repeats. A distinct branch of the Cas2 family shows a very low level of sequence identity and is modeled by TIGR01873 instead of by this model (TIGR01573).


Pssm-ID: 273699  Cd Length: 95  Bit Score: 48.51  E-value: 1.72e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2791440095  36 RRTIIAYDIQND---RRRTKVAKTLESYGD-RVQYSVFVIDIHPAALLR-LKGEVRKIINDrEDSI 96
Cdd:TIGR01573   1 MLVLVVYDIPTDgerKRRRKLRKLLEKYGLqRVQYSVFEGILEPNQLARkLIERLKRIIPD-EGSI 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH