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Conserved domains on  [gi|2791517158|ref|WP_371514689|]
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MDR family MFS transporter [Kocuria sp. WRN011]

Protein Classification

MDR family MFS transporter( domain architecture ID 13025406)

MDR (multi-drug resistance) family major facilitator superfamily (MFS) transporter confers resistance to specific drugs/toxins through their active efflux from the cell

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  27052334|26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 31-490 5.51e-97

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 298.34  E-value: 5.51e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  31 LLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAAL 110
Cdd:cd17503     1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 111 SPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVLPIA 190
Cdd:cd17503    81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 191 VLALIIGltrlkdvgsrgdlrldvlsvvlsvfgfgllvhglstvgaggtqgddsdsfmgwatsagggavilmlgvllvaa 270
Cdd:cd17503   161 ILALLLA------------------------------------------------------------------------- 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 271 falrqlqlqrknnPFLDLRTFKHRDFTVSVALMAVAMMTLFGGVIVLPLYLQTIRGLDTLQTGLILLPGGLIMGLLGPVI 350
Cdd:cd17503   168 -------------PLLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLV 234

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 351 GRLFDAFGPRPLAVPGAALLTFVMFNFSRLQADTAVWWIVTLQIAMSVGLAMIFTPAFTSGLNPLPPKLYSHGSATLSTL 430
Cdd:cd17503   235 GRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTI 314

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2791517158 431 QQVAGAAGTALLVGIMQAGTT------VLQNPDGSTTTDAIPGVHAAFLTATALGVVAFVLTLFMR 490
Cdd:cd17503   315 RQLGGSIGTALLATLLTNRTQfhhsrlSELLAQQVQKQALIIAFNDAFLVSAILLLVGLLLALFLR 380
 
Name Accession Description Interval E-value
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 31-490 5.51e-97

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 298.34  E-value: 5.51e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  31 LLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAAL 110
Cdd:cd17503     1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 111 SPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVLPIA 190
Cdd:cd17503    81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 191 VLALIIGltrlkdvgsrgdlrldvlsvvlsvfgfgllvhglstvgaggtqgddsdsfmgwatsagggavilmlgvllvaa 270
Cdd:cd17503   161 ILALLLA------------------------------------------------------------------------- 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 271 falrqlqlqrknnPFLDLRTFKHRDFTVSVALMAVAMMTLFGGVIVLPLYLQTIRGLDTLQTGLILLPGGLIMGLLGPVI 350
Cdd:cd17503   168 -------------PLLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLV 234

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 351 GRLFDAFGPRPLAVPGAALLTFVMFNFSRLQADTAVWWIVTLQIAMSVGLAMIFTPAFTSGLNPLPPKLYSHGSATLSTL 430
Cdd:cd17503   235 GRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTI 314

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2791517158 431 QQVAGAAGTALLVGIMQAGTT------VLQNPDGSTTTDAIPGVHAAFLTATALGVVAFVLTLFMR 490
Cdd:cd17503   315 RQLGGSIGTALLATLLTNRTQfhhsrlSELLAQQVQKQALIIAFNDAFLVSAILLLVGLLLALFLR 380
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 30-452 3.48e-85

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 271.17  E-value: 3.48e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  30 VLLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAA 109
Cdd:TIGR00711   6 VLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCG 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 110 LSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVLPI 189
Cdd:TIGR00711  86 VAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPI 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 190 AVLALIIGLTRLKDVGSRGDLRLDVLSVVLSVFGFGLLVHGLSTVGAGGTQGDDsdsfmgwatsagggaVILMLGVLLVA 269
Cdd:TIGR00711 166 GIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSN---------------EILILSITGLV 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 270 AFALRQLQLQRKNNPFLDLRTFKHRDFTVSVALMAVAMMTLFGGVIVLPLYLQTIRGLDTLQTGLILLPGGLIMGLLGPV 349
Cdd:TIGR00711 231 AIIAFVVWELTDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPI 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 350 IGRLFDAFGPRPLAVPGAALLTFVMFNFS-RLQADTAVWWIVTLQIAMSVGLAMIFTPAFTSGLNPLPPKLYSHGSATLS 428
Cdd:TIGR00711 311 AGRMGDKIDPRKLVTIGLILYAVGFYWRAfTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSN 390

                         410       420
                  ....*....|....*....|....
gi 2791517158 429 TLQQVAGAAGTALLVGIMQAGTTV 452
Cdd:TIGR00711 391 FTRQLGGSIGTALITTILTNRTQF 414
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
18-437 9.65e-37

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 138.95  E-value: 9.65e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  18 PQTAPGAMGTIAVLLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLA 97
Cdd:COG2814     2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  98 MGSFALGTLLAALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHF 177
Cdd:COG2814    82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 178 PWRSIFWFVLPIAVLALIIGLTRLKDVGSRgdlrldvlsvvlsvfgfgllvhglstvgaggtqgddsdsfmgwatsaggg 257
Cdd:COG2814   162 GWRWVFLVNAVLALLALLLLLRLLPESRPA-------------------------------------------------- 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 258 avilmlgvllvaafalrqlqlQRKNNPFLDLRTFKHRDFTVSVALMAVAMMTLFGGVIVLPLYLQTIRGLDTLQTGLILL 337
Cdd:COG2814   192 ---------------------ARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLA 250

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 338 PGGLIMGLLGPVIGRLFDAFGPRPLAVPGAALLTFVMFNFSRLqadTAVWWIVTLQIAMSVGLAMIFTPAFTSGLNPLPP 417
Cdd:COG2814   251 LFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALA---GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPP 327

                         410       420
                  ....*....|....*....|
gi 2791517158 418 KLYSHGSATLSTLQQVAGAA 437
Cdd:COG2814   328 EARGRASGLYNSAFFLGGPL 347
PRK14995 PRK14995
SmvA family efflux MFS transporter;
27-401 5.16e-28

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 116.75  E-value: 5.16e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  27 TIAVLLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTL 106
Cdd:PRK14995    7 TLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 107 LAALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQR-RGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWF 185
Cdd:PRK14995   87 AAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFTEEKqRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLI 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 186 VLPIAVLALIIGLTRLKDVGSRGDLRLDVLSVVLSVFGFGLLVHGLSTVGAGGTqgddsdsfmgwatSAGGGAVILMLGV 265
Cdd:PRK14995  167 NVPIVLVVMGLTARYVPRQAGRRDQPLNLGHALMLIVAILLLVYSAKTALKGFL-------------SLWVTSLTLLTGA 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 266 LLVAAFALRQLqlqRKNNPFLDLRTFKHRDFTVSVALMAVAMMTLFGGVIVLPLYLQTIRGLDTLQTGLILLPGGLIMGL 345
Cdd:PRK14995  234 LLLGLFIRTQL---AASRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGF 310

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2791517158 346 LGPVIGRLFDAFGPRPLAVPGAALLTFVMFNFSRLQADTAVWWIVTLQIAMSVGLA 401
Cdd:PRK14995  311 SGPIAGILVSRLGLRLVATGGMALSALSFYGLAMTDFSTQQWQAWGLMALLGFSAA 366
MFS_1 pfam07690
Major Facilitator Superfamily;
31-439 6.29e-26

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 108.66  E-value: 6.29e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  31 LLIAAFVVILNETILNVALP-HLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAA 109
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 110 LSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVLPI 189
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 190 AVLALIIGLTRLKDVGSRGDLRLDvlsvvlsvfgfgllvhglstvgaggtqgddsdsfmgwatsagggavilmlgvllva 269
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAE-------------------------------------------------------- 184

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 270 afalrqlqlQRKNNPFLDLRTFKHRDFTVSVALMAVAMMTLFGGVIVLPLYlQTIRGLDTLQTGLILLPGGLIMGLLGPV 349
Cdd:pfam07690 185 ---------EARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLL 254

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 350 IGRLFDAFGPRPLAVPGAALLTFVMFNFSRLQADTAVWWIVTLQIAMSVGLAMIFTPAFTSGLNPLPPKLYSHGSATLST 429
Cdd:pfam07690 255 LGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNT 334

                         410
                  ....*....|
gi 2791517158 430 LQQVAGAAGT 439
Cdd:pfam07690 335 AGSLGGALGP 344
 
Name Accession Description Interval E-value
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 31-490 5.51e-97

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 298.34  E-value: 5.51e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  31 LLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAAL 110
Cdd:cd17503     1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 111 SPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVLPIA 190
Cdd:cd17503    81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 191 VLALIIGltrlkdvgsrgdlrldvlsvvlsvfgfgllvhglstvgaggtqgddsdsfmgwatsagggavilmlgvllvaa 270
Cdd:cd17503   161 ILALLLA------------------------------------------------------------------------- 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 271 falrqlqlqrknnPFLDLRTFKHRDFTVSVALMAVAMMTLFGGVIVLPLYLQTIRGLDTLQTGLILLPGGLIMGLLGPVI 350
Cdd:cd17503   168 -------------PLLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLV 234

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 351 GRLFDAFGPRPLAVPGAALLTFVMFNFSRLQADTAVWWIVTLQIAMSVGLAMIFTPAFTSGLNPLPPKLYSHGSATLSTL 430
Cdd:cd17503   235 GRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTI 314

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2791517158 431 QQVAGAAGTALLVGIMQAGTT------VLQNPDGSTTTDAIPGVHAAFLTATALGVVAFVLTLFMR 490
Cdd:cd17503   315 RQLGGSIGTALLATLLTNRTQfhhsrlSELLAQQVQKQALIIAFNDAFLVSAILLLVGLLLALFLR 380
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 30-452 3.48e-85

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 271.17  E-value: 3.48e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  30 VLLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAA 109
Cdd:TIGR00711   6 VLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCG 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 110 LSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVLPI 189
Cdd:TIGR00711  86 VAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPI 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 190 AVLALIIGLTRLKDVGSRGDLRLDVLSVVLSVFGFGLLVHGLSTVGAGGTQGDDsdsfmgwatsagggaVILMLGVLLVA 269
Cdd:TIGR00711 166 GIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSN---------------EILILSITGLV 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 270 AFALRQLQLQRKNNPFLDLRTFKHRDFTVSVALMAVAMMTLFGGVIVLPLYLQTIRGLDTLQTGLILLPGGLIMGLLGPV 349
Cdd:TIGR00711 231 AIIAFVVWELTDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPI 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 350 IGRLFDAFGPRPLAVPGAALLTFVMFNFS-RLQADTAVWWIVTLQIAMSVGLAMIFTPAFTSGLNPLPPKLYSHGSATLS 428
Cdd:TIGR00711 311 AGRMGDKIDPRKLVTIGLILYAVGFYWRAfTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSN 390

                         410       420
                  ....*....|....*....|....
gi 2791517158 429 TLQQVAGAAGTALLVGIMQAGTTV 452
Cdd:TIGR00711 391 FTRQLGGSIGTALITTILTNRTQF 414
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 31-490 5.84e-54

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 185.84  E-value: 5.84e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  31 LLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAAL 110
Cdd:cd17321     1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 111 SPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVLPIA 190
Cdd:cd17321    81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 191 VLALIIGltrlkdvgsrgdlrldvlsvvlsvfgfgllvhglstvgaggtqgddsdsfmgwatsagggavilmlgvllvaa 270
Cdd:cd17321   161 LVALLLA------------------------------------------------------------------------- 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 271 falrqlqlqrknnpfldlrtfkhRDFTVSVALMAVAMMTLFGGVIVLPLYLQTIRGLDTLQTGLILLPGGLIMGLLGPVI 350
Cdd:cd17321   168 -----------------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLA 224

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 351 GRLFDAFGPRPLAVPGAALLTFVMFNFSRLQADTAVWWIVTLQIAMSVGLAMIFTPAFTSGLNPLPPKLYSHGSATLSTL 430
Cdd:cd17321   225 GRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTA 304

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2791517158 431 QQVAGAAGTALLVGIMQAGTTV-LQNPDGSTTTDAIP-----GVHAAFLTATALGVVAFVLTLFMR 490
Cdd:cd17321   305 RQLGGALGVALLGALLTAGLSAnLGDSGVAALLSAAAaafaaGFHLAFLVAAALALLAALLALLLP 370
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
18-437 9.65e-37

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 138.95  E-value: 9.65e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  18 PQTAPGAMGTIAVLLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLA 97
Cdd:COG2814     2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  98 MGSFALGTLLAALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHF 177
Cdd:COG2814    82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 178 PWRSIFWFVLPIAVLALIIGLTRLKDVGSRgdlrldvlsvvlsvfgfgllvhglstvgaggtqgddsdsfmgwatsaggg 257
Cdd:COG2814   162 GWRWVFLVNAVLALLALLLLLRLLPESRPA-------------------------------------------------- 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 258 avilmlgvllvaafalrqlqlQRKNNPFLDLRTFKHRDFTVSVALMAVAMMTLFGGVIVLPLYLQTIRGLDTLQTGLILL 337
Cdd:COG2814   192 ---------------------ARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLA 250

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 338 PGGLIMGLLGPVIGRLFDAFGPRPLAVPGAALLTFVMFNFSRLqadTAVWWIVTLQIAMSVGLAMIFTPAFTSGLNPLPP 417
Cdd:COG2814   251 LFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALA---GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPP 327

                         410       420
                  ....*....|....*....|
gi 2791517158 418 KLYSHGSATLSTLQQVAGAA 437
Cdd:COG2814   328 EARGRASGLYNSAFFLGGPL 347
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 31-490 2.28e-36

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 138.48  E-value: 2.28e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  31 LLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAAL 110
Cdd:cd17504     1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 111 SPSFAILLVARVIQAFGSAiMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVLPIA 190
Cdd:cd17504    81 APNLPVLIAGRALQGIGGA-VFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 191 VLALIIgltrlkdvgsrgdlrldvlsvvlsvfgfgllvhglstvgaggtqgddsdsfmgwatsagggavilmlgvllvaa 270
Cdd:cd17504   160 VLLAAL-------------------------------------------------------------------------- 165

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 271 falrqlqlqrknNPFLDLRTFKHRDFTVSVALMAVAMMTLFGGVIVLPLYLQTIR----GLDTLQTGLILLPGGLIMGLL 346
Cdd:cd17504   166 ------------VPLIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTptgfGLGITEAGLLLLPGALVMLIA 233

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 347 GPVIGRLFDAFGPRPLAVPGAALLT--FVMFNFSRlqadTAVWWIVTLQIAMSVGLAMIFTPAFTSGLNPLPPKLYSHGS 424
Cdd:cd17504   234 GPLAGRLIARVGPRRVLLIGLVISAvgLLLLALLH----SSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIAT 309

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2791517158 425 ATLSTLQQVAGAAGTALLVGIMQAGTTVLQNPDGSTTTdaipGVHAAFLTATALGVVAFVLTLFMR 490
Cdd:cd17504   310 GMNTVLRTIGSAIGPAIAGAILTTYTVSITSGGVPTEG----AYVLAFLIGAALALAALLLSLLIP 371
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 31-490 4.18e-34

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 131.15  E-value: 4.18e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  31 LLIAAFVVILNETILNVALPHLMEDLHvDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAAL 110
Cdd:cd17502     1 LMLALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 111 SPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVLPIA 190
Cdd:cd17502    80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 191 VLALIIGLTrlkdvgsrgdlrldvlsvvlsvfgfgllvhglstvgaggtqgddsdsfmgwatsagggavilmlgvllvaa 270
Cdd:cd17502   160 GLALALLRT----------------------------------------------------------------------- 168

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 271 falrqlqlqrknnpfldlrtfkhrdFTVSVALMAVAMMTLFGGVIVLPLYLQTIRGLDTLQTGLILLPGGLIMGLLGPVI 350
Cdd:cd17502   169 -------------------------ILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIIS 223

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 351 GRLFDAFG-PRPLAVPGAALLTFVMFNFSRLQADTAVWWIVTLQIAMSVGLAMIFTPAFTSGLNPLPPKLYSHGSATLST 429
Cdd:cd17502   224 GALISKTGrYKPLIVIGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTF 303

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2791517158 430 LQQVAGAAGTALlvgimqagttvlqnpdgstttdaipgvHAAFLTATALGVVAFVLTLFMR 490
Cdd:cd17502   304 FRSLGGTLGVAI---------------------------TDVFLVALALAALAFLLSLFLP 337
PRK14995 PRK14995
SmvA family efflux MFS transporter;
27-401 5.16e-28

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 116.75  E-value: 5.16e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  27 TIAVLLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTL 106
Cdd:PRK14995    7 TLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 107 LAALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQR-RGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWF 185
Cdd:PRK14995   87 AAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFTEEKqRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLI 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 186 VLPIAVLALIIGLTRLKDVGSRGDLRLDVLSVVLSVFGFGLLVHGLSTVGAGGTqgddsdsfmgwatSAGGGAVILMLGV 265
Cdd:PRK14995  167 NVPIVLVVMGLTARYVPRQAGRRDQPLNLGHALMLIVAILLLVYSAKTALKGFL-------------SLWVTSLTLLTGA 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 266 LLVAAFALRQLqlqRKNNPFLDLRTFKHRDFTVSVALMAVAMMTLFGGVIVLPLYLQTIRGLDTLQTGLILLPGGLIMGL 345
Cdd:PRK14995  234 LLLGLFIRTQL---AASRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGF 310

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2791517158 346 LGPVIGRLFDAFGPRPLAVPGAALLTFVMFNFSRLQADTAVWWIVTLQIAMSVGLA 401
Cdd:PRK14995  311 SGPIAGILVSRLGLRLVATGGMALSALSFYGLAMTDFSTQQWQAWGLMALLGFSAA 366
MFS_1 pfam07690
Major Facilitator Superfamily;
31-439 6.29e-26

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 108.66  E-value: 6.29e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  31 LLIAAFVVILNETILNVALP-HLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAA 109
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 110 LSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVLPI 189
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 190 AVLALIIGLTRLKDVGSRGDLRLDvlsvvlsvfgfgllvhglstvgaggtqgddsdsfmgwatsagggavilmlgvllva 269
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAE-------------------------------------------------------- 184

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 270 afalrqlqlQRKNNPFLDLRTFKHRDFTVSVALMAVAMMTLFGGVIVLPLYlQTIRGLDTLQTGLILLPGGLIMGLLGPV 349
Cdd:pfam07690 185 ---------EARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLL 254

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 350 IGRLFDAFGPRPLAVPGAALLTFVMFNFSRLQADTAVWWIVTLQIAMSVGLAMIFTPAFTSGLNPLPPKLYSHGSATLST 429
Cdd:pfam07690 255 LGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNT 334

                         410
                  ....*....|
gi 2791517158 430 LQQVAGAAGT 439
Cdd:pfam07690 335 AGSLGGALGP 344
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 14-276 9.20e-25

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 104.12  E-value: 9.20e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  14 AEHPPQTAPGAMGTIAVLLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAV 93
Cdd:COG0477     2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  94 FGLAMGSFALGTLLAALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVI 173
Cdd:COG0477    82 LLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 174 LNHFPWRSIFWFVLPIAVLALIIGLTRLKDVGSRGDLRLDVLSVVLSVFGFGLLVHGLSTVGAGGTQGDDSDSFMGWATS 253
Cdd:COG0477   162 VAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLL 241

                         250       260
                  ....*....|....*....|...
gi 2791517158 254 AGGGAVILMLGVLLVAAFALRQL 276
Cdd:COG0477   242 LLALLLLALLLLLALLLLAALLL 264
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 31-490 4.60e-24

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 103.81  E-value: 4.60e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  31 LLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAAL 110
Cdd:cd17325     1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 111 SPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVLPIA 190
Cdd:cd17325    81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 191 VLALIIGLTRLKDVGSRGDLRLDVLSVVLSVfgfgllvhglstvgaggtqgddsdsfmgwatsagggavilmlgvllvaa 270
Cdd:cd17325   161 LLALVLALLLLPEPRPPPNKRAVSAARLRSG------------------------------------------------- 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 271 falrqlqlqrknnpfldLRTFKHRDFTVSVALMAVAMMTLFGGVI-VLPLYLQTIRGLDTLQTGLILLPGGLIMGLLGPV 349
Cdd:cd17325   192 -----------------LRLLLRDRRLLALFLAIFVLAFAFGALEpFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPP 254

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 350 IGRLFDAFGPRPLAVPGAALLTFVMFNFSRLqadTAVWWIVTLQIAMSVGLAMIFTPAFTSGLNPLPPKLYSHGSATLST 429
Cdd:cd17325   255 AGKLSDRIGRKPLILIGLLLSAVALLLLPLA---TSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNT 331

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2791517158 430 LQQVAGAAGTALLVGIMQAGttvlqnpdgstttdaipGVHAAFLTATALGVVAFVLTLFMR 490
Cdd:cd17325   332 AFSLGMVLGPLLGGFLYDAF-----------------GFATPFLAAAALLLLAAVLFLLLR 375
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 28-442 8.81e-24

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 103.04  E-value: 8.81e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  28 IAVLLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLL 107
Cdd:cd17320     1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 108 AALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVL 187
Cdd:cd17320    81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 188 PIAVLALIIGLTRLKDVGSRGDlRLDVLSVVLSVFGfgllvhglstvgaggtqgddsdsfmgwatsagggavilmlgvll 267
Cdd:cd17320   161 LLGLLLLLLVLLFLPETLPEEK-RKPLLSSLLRAYK-------------------------------------------- 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 268 vaafalrqlqlqrknnpfldlRTFKHRDFTVSVALMAVAMMTLFGGVIVLPLYLQTIRGLDTLQTGLILLPGGLIMGLLG 347
Cdd:cd17320   196 ---------------------RVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGS 254

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 348 PVIGRLFDAFGPRPLAVPGAALLTF--VMFNFSRLQADTAVWWIVTLQIAMSVGLAMIFTPAFTSGLNPLpPKLYSHGSA 425
Cdd:cd17320   255 LLNGRLVRRFGPRRLLRLGLLLLLAaaLVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPF-PHVAGTASA 333

                         410
                  ....*....|....*..
gi 2791517158 426 TLSTLQQVAGAAGTALL 442
Cdd:cd17320   334 LLGFLQFLIGALAGALV 350
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
28-495 2.75e-23

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 101.10  E-value: 2.75e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  28 IAVLLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLL 107
Cdd:COG2271    12 LALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 108 AALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVL 187
Cdd:COG2271    92 FGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILG 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 188 PIAVLALIIGLtrlkdvgsrgdlrldvlsvvlsvfgfgllvhglstvgaggtqgddsdsfmgwatsagggavilmlgVLL 267
Cdd:COG2271   172 LPGLLLALLRF------------------------------------------------------------------WLL 185

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 268 VAAFALrqlqlqrknnpfldlrtfkhrdftvsvalmavAMMTLFGGVIVLPLYLQTIRGLDTLQTGLILLPGGLIMGLLG 347
Cdd:COG2271   186 ALAYFL--------------------------------VYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGS 233

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 348 PVIGRLFDAFGPRPLAVPGAALLTFVMFNFSRLQADTaVWWIVTLQIAMSVGLAMIFTPAFTSGLNPLPPKLYSHGSATL 427
Cdd:COG2271   234 LLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPS-PALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLV 312

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2791517158 428 STLQQVAGAAGTALLVGIMQAGttvlqnpdgstttdaipGVHAAFLTATALGVVAFVLTLFMRKATPE 495
Cdd:COG2271   313 NTFGFLGGALGPLLVGYLLDAT-----------------GYQAAFLLLAALALLAALLALLLLRETRK 363
PRK10504 PRK10504
putative transporter; Provisional
 36-445 1.39e-22

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 100.58  E-value: 1.39e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  36 FVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAALSPSFA 115
Cdd:PRK10504   20 FMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLN 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 116 ILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVLPIAVLALI 195
Cdd:PRK10504  100 ELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAI 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 196 IGLTRLKDVGSRGDlRLDVLSVVLSVFGFGLLvhglsTVGAGGTQGDdsdsfmgwatsagGGAVILMLGVLLVAAFALRQ 275
Cdd:PRK10504  180 ATLMLMPNYTMQTR-RFDLSGFLLLAVGMATL-----TLALDGSKGL-------------GLSPLAIAGLVAVGVVALLL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 276 LQLQRKNNPF--LDLRTFKHRDFtvSVALMAVAMMTLFGGVI--VLPLYLQTIRGLDTLQTGLILLPggLIMGLLG--PV 349
Cdd:PRK10504  241 YLLHARNNNRalFSLKLFRTRTF--SLGLAGSFAGRIGSGMLpfMTPVFLQIGLGFSPFHAGLMMIP--MVLGSMGmkRI 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 350 IGRLFDAFGPRPLAVPGAALLTFVMFNFSRLQADTAVWWIVTLQIAMSVGLAMIFTPAFTSGLNPLPPKLYSHGSATLST 429
Cdd:PRK10504  317 VVQVVNRFGYRRVLVATTLGLALVSLLFMLVALLGWYYLLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSM 396

                         410
                  ....*....|....*....
gi 2791517158 430 LQQVAGAAGTA---LLVGI 445
Cdd:PRK10504  397 IMQLSMSIGVTiagLLLGL 415
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 30-239 8.62e-22

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 96.85  E-value: 8.62e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  30 VLLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAA 109
Cdd:cd17324     3 ALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 110 LSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVLPI 189
Cdd:cd17324    83 LAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVL 162

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2791517158 190 AVLALIIGLTRLKDVGSRGDLRLDVLSVVLSVFGFGLLVHGLSTVGAGGT 239
Cdd:cd17324   163 ALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFG 212
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 28-196 1.65e-19

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 90.32  E-value: 1.65e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  28 IAVLLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLL 107
Cdd:cd17474     1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 108 AALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNhFPWRSIFWFVL 187
Cdd:cd17474    81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLA 159


                  ....*....
gi 2791517158 188 PIAVLALII 196
Cdd:cd17474   160 ALIPVAFLA 168
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 29-445 4.45e-19

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 89.99  E-value: 4.45e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  29 AVLLIAAFVVILNETILNVALPHLMEDLHvDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLA 108
Cdd:cd06179     1 AALCLAYFAQLFGVTLPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 109 ALSPSFAILLVARVIQAFGSAImLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFP--WRSIFWFV 186
Cdd:cd06179    80 GTAKSVNMLIGGQALIGIGAGT-QGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAagWRWIFYIN 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 187 LPIAVLALIIGL--------TRLKDVGSRGDLR-LDVLSVVLSVFGFGLLVHGLSTvgaGGTQGddsdsfmgWATSAggg 257
Cdd:cd06179   159 AIFNALALILLFffyhppprPQLHGSSTRQKLKrLDWVGLFLLIAGLVLFLLGLSW---GGNPY--------PWSSA--- 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 258 AVI--LMLGVLLVAAFALRQLqLQRKNNPFLDLRTFKHRDFTVSVALMAVAMMTLFGGVIVLPLYLQTIRGLDTLQTGLI 335
Cdd:cd06179   225 HVIapLVIGGVLLIAFGLYEW-KGTKDGLLPPRLLFRGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLY 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 336 LLPGGLIMGLLGPVIGRLFDAFG-PRPLAVPGAALLTFVMFNFSRLQADTavwwiVTLQIAMSV----GLAMIFTPAFTS 410
Cdd:cd06179   304 QLPFGLGTLFGAILAGLLLTKIKhIKWQLVAGFVLFTAFLALLALITPDN-----KALAIAFSVlagiGIGGPLVLAIVI 378

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 2791517158 411 GLNPLPPKLYSHGSATLSTLQQVAGAAGTALLVGI 445
Cdd:cd06179   379 VQLSVPPEDIGTASGLLGSARALGGAVGTAIFTSI 413
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
22-491 2.51e-17

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 83.78  E-value: 2.51e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  22 PGAMGTIAVLLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSF 101
Cdd:COG2223     1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 102 ALGTLLAALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRS 181
Cdd:COG2223    81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 182 IFWFVLPIAVLALIIGLTRLKDVgsrgdlrldvlsvvlsvfgfgllvhglstvgAGGTQGDDSDSFMGWatsagggavil 261
Cdd:COG2223   161 AFLILGILLLVVAVLAWLFLRDP-------------------------------PAGAAAAAKASLRDQ----------- 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 262 mlgvllvaafalrqlqlqrknnpfldLRTFKHRDFTVSVALMAVAMMTLFGGVIVLPLYLQTIRGLDTLQTGLILLPGGL 341
Cdd:COG2223   199 --------------------------LEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFAL 252

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 342 IMGLLGPVIGRLFDAFGPRPLAVPGAALLTFVMFNFSrlQADTAVWWIVTLQIAMSVGLAMIFTPAFTSGLNPLPPKLYS 421
Cdd:COG2223   253 LGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLA--LALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAG 330

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 422 HGSATLSTLQQVAGAAGTALLvgimqagttvlqnpdgSTTTDAIPGVHAAFLTATALGVVAFVLTLFMRK 491
Cdd:COG2223   331 AVYGLVGAAGGLGGFLGPLLF----------------GALLDATGSYTAAFLVFAVLALVALVLTLLLYR 384
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 28-233 7.77e-17

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 81.85  E-value: 7.77e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  28 IAVLLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLL 107
Cdd:cd17319     5 IPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTAL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 108 AALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFvl 187
Cdd:cd17319    85 TGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII-- 162

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 2791517158 188 pIAVLALIIGLTRLKDVGSrgdlrldVLSVVLSVFGFGLLVHGLST 233
Cdd:cd17319   163 -EGLLGLLLAVLWWFYLRQ-------VWGLALGYFGINYALYGLLT 200
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 28-198 1.67e-15

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 78.00  E-value: 1.67e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  28 IAVLLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLL 107
Cdd:cd17323     1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 108 AALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVL 187
Cdd:cd17323    81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160

                         170
                  ....*....|.
gi 2791517158 188 PIAVLALIIGL 198
Cdd:cd17323   161 IISGFCLILIF 171
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 27-194 1.22e-14

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 75.50  E-value: 1.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  27 TIAVLLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTL 106
Cdd:TIGR00710   6 FALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 107 LAALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFV 186
Cdd:TIGR00710  86 GLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFL 165


                  ....*...
gi 2791517158 187 LPIAVLAL 194
Cdd:TIGR00710 166 SLAGILLS 173
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 31-241 1.33e-14

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 75.32  E-value: 1.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  31 LLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAAL 110
Cdd:cd17489     1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 111 SPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVLPIA 190
Cdd:cd17489    81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2791517158 191 VLALIIGLTRLKDVGSRGDLRLDVLSVVLSVFGFGLLVHGLSTVGAGGTQG 241
Cdd:cd17489   161 LLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYG 211
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 31-204 4.87e-13

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 70.53  E-value: 4.87e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  31 LLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAAL 110
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 111 SPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNH--FPWRSIFWFVLP 188
Cdd:cd06174    81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160

                         170
                  ....*....|....*.
gi 2791517158 189 IAVLALIIGLTRLKDV 204
Cdd:cd06174   161 LALLAAILLLLVVPDP 176
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
10-202 8.09e-13

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 69.90  E-value: 8.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  10 SGGTAEHPPQTAPGAMGTIAVLLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVS 89
Cdd:COG2807     2 STTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  90 TRAVFGLAMGSFALGTLLAALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKqRRGLVMGNVSIVISVAPALGPTI 169
Cdd:COG2807    82 LERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGL 160

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2791517158 170 SGVILNHFPWRSIFWFVLPIAVLALIIGLTRLK 202
Cdd:COG2807   161 TVPLAAALGWRGALAVWALLALLALLLWLPLLR 193
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 26-196 8.30e-13

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 69.91  E-value: 8.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  26 GTIAVLLIAAFVVILNETILNVALP-HLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALG 104
Cdd:cd17325   199 RRLLALFLAIFVLAFAFGALEPFLPlYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 105 TLLAALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFW 184
Cdd:cd17325   279 LLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFL 358

                         170
                  ....*....|..
gi 2791517158 185 FVLPIAVLALII 196
Cdd:cd17325   359 AAAALLLLAAVL 370
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 26-196 3.79e-12

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 67.60  E-value: 3.79e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  26 GTIAVLLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQK-VSTRAVFGLAMGSFALG 104
Cdd:cd17474   199 GLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALS 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 105 TLLAALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFW 184
Cdd:cd17474   279 LLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFL 358

                         170
                  ....*....|..
gi 2791517158 185 FVLPIAVLALII 196
Cdd:cd17474   359 VGAAIALAAAVL 370
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 5-198 2.36e-11

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 65.29  E-value: 2.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158   5 PSQPASGGTAEHPPQTAPGAMGTIAVLLIAAFVVILNETILNVALPHLMEDLH-VDAATVQWVATAFMLTMAVVIPTTGF 83
Cdd:cd17473   176 PARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGgGSAALIGLALAIASLAGAIGALLFGR 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  84 LLQKVSTRAVFGLAMGSFALGTLLAALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAP 163
Cdd:cd17473   256 LKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQ 335

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2791517158 164 ALGPTISGVILNHFPWRSIFWFVLPIAVLALIIGL 198
Cdd:cd17473   336 FLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVL 370
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
23-204 2.45e-11

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 65.28  E-value: 2.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  23 GAMGTIAVLLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKV--STRAVFGLAMGS 100
Cdd:COG2271   178 ALLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgrRRKLVLAIGLLL 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 101 FALGTLLAALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWR 180
Cdd:COG2271   258 AALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ 337

                         170       180
                  ....*....|....*....|....
gi 2791517158 181 SIFWFVLPIAVLALIIGLTRLKDV 204
Cdd:COG2271   338 AAFLLLAALALLAALLALLLLRET 361
2_A_01_02 TIGR00880
Multidrug resistance protein;
68-195 4.19e-11

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 60.74  E-value: 4.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  68 TAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQR 147
Cdd:TIGR00880   5 AGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEE 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2791517158 148 RGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVLPIAVLALI 195
Cdd:TIGR00880  85 RGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFI 132
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 27-196 8.60e-11

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 63.91  E-value: 8.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  27 TIAVLLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTL 106
Cdd:TIGR00895  18 AIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 107 LAALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWF- 185
Cdd:TIGR00895  98 LCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVg 177

                         170
                  ....*....|..
gi 2791517158 186 -VLPIAVLALII 196
Cdd:TIGR00895 178 gIAPLLLLLLLM 189
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
30-228 1.85e-10

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 62.56  E-value: 1.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  30 VLLIAAFVVI-LNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLA 108
Cdd:COG0738    11 IAIYLLFFLWgFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLF 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 109 ALSPSFAILLVARVIQAFGSAIMLPlLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNH---FPWRSIFWF 185
Cdd:COG0738    91 ALAPSYPLLLLALFLLGLGLGLLDV-AANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLI 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2791517158 186 V-LPIAVLALIIGLTRLKDVGSRGDLRLDVLSVVLSVFGFGLLV 228
Cdd:COG0738   170 LaVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLL 213
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 43-197 4.04e-10

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 61.45  E-value: 4.04e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  43 TILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAALSPSFAILLVARV 122
Cdd:cd17365    16 AVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRF 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2791517158 123 IQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWF--VLPIAVLALIIG 197
Cdd:cd17365    96 LTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLggVPPLILLPLLRG 172
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 31-196 6.85e-10

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 60.65  E-value: 6.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  31 LLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAAL 110
Cdd:cd17478     1 LSLGHFLNDFYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 111 SPSFAILLVARVIQAFGSAIMLPLLMtTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVLPIA 190
Cdd:cd17478    81 APNYWLLLLLVALAGIGSAAFHPEGA-RLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPG 159


                  ....*.
gi 2791517158 191 VLALII 196
Cdd:cd17478   160 LAVALL 165
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
28-198 8.17e-10

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 60.64  E-value: 8.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  28 IAVLLIAAFVVILNETILNVALP-HLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTL 106
Cdd:COG0738   212 LLLGGLAIFLYVGAEGAIGDWLPlYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLL 291

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 107 LAALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKqRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFV 186
Cdd:COG0738   292 LALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGK-RTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVP 370

                         170
                  ....*....|..
gi 2791517158 187 LPIAVLALIIGL 198
Cdd:COG0738   371 LVCYLLILLLAL 382
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 29-228 1.55e-09

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 59.58  E-value: 1.55e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  29 AVLLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLA 108
Cdd:cd17476     1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 109 ALSPSFAILLVARVIQAFGSAIMLPLLMTTI-LTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVL 187
Cdd:cd17476    81 GFSPNFIFFIICRALQGLGPAFLLPNAMALLgRTYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLA 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2791517158 188 PIAVLALIIGLTRLkdvgsRGDLRLDVLSVVLSVFGFGLLV 228
Cdd:cd17476   161 ILAAIVAVAAIFWT-----SPSFIAVLLAVFLGWASFGIWV 196
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
47-203 1.55e-09

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 59.65  E-value: 1.55e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  47 VALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAALSPSFAILLVARVIQAF 126
Cdd:PRK10473   24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2791517158 127 GSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVLPIAVLALIIGLTRLKD 203
Cdd:PRK10473  104 GAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSLFILKE 180
emrD PRK11652
multidrug transporter EmrD;
31-202 2.78e-09

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 59.15  E-value: 2.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  31 LLIAAFVVI--LNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLA 108
Cdd:PRK11652   11 FMLVLLVAVgqMAQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVA 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 109 ALSPSFAILLVARVIQAFGSAIMLPLLMTtiltlVPK---QRRGLVMGN--VSIVISVAPALGPTISGVILNHFPWRSIF 183
Cdd:PRK11652   91 LFAHSLTVLIAASAIQGLGTGVGGVMART-----LPRdlyEGTQLRHANslLNMGILVSPLLAPLIGGLLTTLFGWRACY 165

                         170
                  ....*....|....*....
gi 2791517158 184 WFVLPIAVLALIIGLTRLK 202
Cdd:PRK11652  166 LFLLLLGAGVTFSMARWMP 184
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 29-199 4.66e-09

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 58.40  E-value: 4.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  29 AVLLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLA 108
Cdd:cd17328     2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 109 ALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFP-WRSIFWFV- 186
Cdd:cd17328    82 SFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGgWRWAFRVTg 161

                         170
                  ....*....|...
gi 2791517158 187 LPIAVLALIIGLT 199
Cdd:cd17328   162 VLGVLLAILLLLF 174
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 33-203 1.30e-08

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 57.00  E-value: 1.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  33 IAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAALSP 112
Cdd:TIGR00881   2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 113 SFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILN-HFPWRSIFWFVLPIAV 191
Cdd:TIGR00881  82 SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAeLYSWHWVFIVPGIIAI 161

                         170
                  ....*....|..
gi 2791517158 192 LALIIGLTRLKD 203
Cdd:TIGR00881 162 IVSLICFLLLRD 173
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 31-194 1.59e-08

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 56.41  E-value: 1.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  31 LLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAAL 110
Cdd:cd17477     1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 111 SPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPtisgVILNHFPWRSIFWFVLPIA 190
Cdd:cd17477    81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGP----LLLALVGTAGALPFLIAAV 156


                  ....
gi 2791517158 191 VLAL 194
Cdd:cd17477   157 LLLL 160
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 1-198 3.26e-08

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 55.63  E-value: 3.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158   1 MPSSPSQPASGGTAEHPPQTAPGAMGTIAVLLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPT 80
Cdd:cd17324   174 LPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPL 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  81 TGFLLQKVSTRAVFGLAMGSFALGTLLAALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRrGLVMGNVSIVIS 160
Cdd:cd17324   254 AGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR-GLASSLYLAAYN 332

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2791517158 161 VAPALGPTISGVILNHFPWRSIFWFVLPIAVLALIIGL 198
Cdd:cd17324   333 LGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
30-177 5.61e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 54.91  E-value: 5.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  30 VLLIAAFVVILNETILNVALPHLMED-LHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLA 108
Cdd:COG2211   232 LLLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL 311

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2791517158 109 ALSP--SFAILLVARVIQAFGSAIMLPLLMTTILTLVP-------KQRRGLVMGNVSIVISVAPALGPTISGVILNHF 177
Cdd:COG2211   312 FFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLLALF 389
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 28-200 1.68e-07

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 53.39  E-value: 1.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  28 IAVLLIAAFVVILNETILNVALP-HLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTL 106
Cdd:cd06173   210 LRLLLLALALFALLGGALTVLLPlLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALL 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 107 LAALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFV 186
Cdd:cd06173   290 VLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLA 369

                         170
                  ....*....|....
gi 2791517158 187 LPIAVLALIIGLTR 200
Cdd:cd06173   370 GALLLLAALLLLLL 383
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 28-196 1.92e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 52.99  E-value: 1.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  28 IAVLLIAAFVVILNETILNVALPHLMEDLHVDAATVQ--WVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGT 105
Cdd:cd17316     1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQtgLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 106 LLAALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFP----WRS 181
Cdd:cd17316    81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWRI 160

                         170
                  ....*....|....*
gi 2791517158 182 IFWFVLPIAVLALII 196
Cdd:cd17316   161 LFLIGALPALLALLL 175
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 25-196 2.10e-07

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 52.97  E-value: 2.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  25 MGTIAVLLIAAFVVILNETILNVALPHLMED-LHVDAATVQWVATAFMLTMAVV-IPTTGFLLQKVSTRAVFGLAMGSFA 102
Cdd:cd17330   173 LPPLRRLLLVYFLIALAFAGLESVFSLFLKDrFGFSPSQIGLLLALVGIAGILAqLLLIPRLAKRLGERKLLRLGLLLAI 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 103 LGTLLAALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSI 182
Cdd:cd17330   253 IGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVP 332

                         170
                  ....*....|....
gi 2791517158 183 FWFVLPIAVLALII 196
Cdd:cd17330   333 FLLAAGLLLIALFL 346
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
48-202 3.62e-07

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 52.22  E-value: 3.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  48 ALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAALSPSFAILLVARVIQAFG 127
Cdd:PRK11102   13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2791517158 128 SAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVLPIAVLALIIGLTRLK 202
Cdd:PRK11102   93 AAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIP 167
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 93-204 7.98e-07

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 51.06  E-value: 7.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  93 VFGLAMgsFALGTLLAALSPSFAILLVARVIQafGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGV 172
Cdd:cd17472    66 LFGLLL--FIAGSLLAAYATSIYGLILGRALQ--GSGAISSVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPL 141

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2791517158 173 ILNHFPWRSIFWFVLPIAVLALIIGLTRLKDV 204
Cdd:cd17472   142 LAAHLGVSGLFLITAILSLVSLLILLFFVPDP 173
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 31-196 9.58e-07

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 51.07  E-value: 9.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  31 LLIAAFVVILNETILNVALP-HLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAA 109
Cdd:cd17329   205 FLLASFLISLIYFQLESTLPvYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLA 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 110 LSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVLPI 189
Cdd:cd17329   285 FANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAAL 364


                  ....*..
gi 2791517158 190 AVLALII 196
Cdd:cd17329   365 GLIAAAL 371
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 51-196 9.91e-07

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 51.00  E-value: 9.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  51 HLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAALSPSFAILLVARVIQAFGSAI 130
Cdd:cd17370   224 LRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGA 303

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2791517158 131 MLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVLPIAVLALII 196
Cdd:cd17370   304 QESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLL 369
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
54-195 1.41e-06

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 50.66  E-value: 1.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  54 EDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAALSPSFAILLVARVIQAFGSAIMLP 133
Cdd:PRK11043   34 ADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGVCSAAV 113

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2791517158 134 LLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVLPIAVLALI 195
Cdd:PRK11043  114 IWQALVIDRYPAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWQAIFATLFAITLLLIL 175
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 27-174 2.14e-06

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 49.88  E-value: 2.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  27 TIAVLLIAAFVVILNETILNVALPHLMED-----LHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSF 101
Cdd:cd17504   178 NVLLANITALLAGFGMFMVFQLLPQLLQLptptgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVIS 257

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2791517158 102 ALGTLLAALSP-SFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVIL 174
Cdd:cd17504   258 AVGLLLLALLHsSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAIL 331
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 30-195 2.65e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 49.49  E-value: 2.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  30 VLLIAAFVVILNETILNVALPHLMEDLH-VDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLA 108
Cdd:cd17473     3 TLLLASTLTVMAGAAIAPALPAIAQHFVpNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 109 ALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNhFPWRSIFW---F 185
Cdd:cd17473    83 LFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLvylL 161

                         170
                  ....*....|
gi 2791517158 186 VLPIAVLALI 195
Cdd:cd17473   162 ALPVLILVLL 171
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
244-490 4.19e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 49.13  E-value: 4.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 244 SDSFMGWATSAGGGAVILMLGVLLVAAFALRQLQLQRKNNPFLDL--RTFKHRDFTVSVALMAVAMMTLFGGVIVLPLYL 321
Cdd:COG2211   176 GDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESlkALLKNRPFLLLLLAYLLFFLALALVAALLLYYF 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 322 QTIRGLDTLQTGLILLPGGLIMGLLGPVIGRLFDAFGPRPLAVPGAALLTFVMFNFSRLQADTaVWWIVTLQIAMSVGLA 401
Cdd:COG2211   256 KYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGN-LWLLLVLAALAGIGLG 334

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 402 MIFTPAFTSGLNPLPPKLYSHG-------SATLSTLQQVAGAAGTALLVGIMQAGTTVLQNPDGSTTTDAIpgVHAAFLT 474
Cdd:COG2211   335 AILVLPWAMLADVVDYDEWKTGrrreglyFGIFTFAIKLGQALAGALAGLLLALFGYVAGAAQSPSALTGI--RLLFFLL 412

                         250
                  ....*....|....*.
gi 2791517158 475 ATALGVVAFVLTLFMR 490
Cdd:COG2211   413 PAVLLLLAALLLLFYP 428
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 50-198 8.60e-06

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 47.99  E-value: 8.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  50 PHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKV---STRAVFGLAMGSFAlgTLLAALSPSFAILLVARVIQAF 126
Cdd:cd17490   219 PLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYKKlgeRNTIIIGFLLLGAY--CFLIPFAPNLTLLYLLQALNGF 296

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2791517158 127 GSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVLPIAVLALIIGL 198
Cdd:cd17490   297 GTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSL 368
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 47-199 1.30e-05

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 47.16  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  47 VALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAALSPSFAILLVAR-VIQA 125
Cdd:cd17352    24 VLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYgVLGG 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2791517158 126 FGSAIMLPLLMTTILTLVPKqRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVLPIAVLALIIGLT 199
Cdd:cd17352   104 LGLGLIYSPAIVIVGQYFEK-KRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLL 176
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 82-199 2.62e-05

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 46.47  E-value: 2.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  82 GFLLQKVSTRAVFGLAMGSFALGTLLAALSPSFAILLVARVIQAFGSAIM--LPLLMTTILTLVPKQRRGLVMGNVSIVI 159
Cdd:cd17313   302 GKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATIniNPYPLVSDYHSESGRGQGTDTGLLNLAI 381

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2791517158 160 SVAPALGPTISGVILNHFPWRSIFWFVLPIAVLALIIGLT 199
Cdd:cd17313   382 SLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVGALF 421
MFS_ARN_like cd17322
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ...
 94-440 4.50e-05

Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340880 [Multi-domain]  Cd Length: 514  Bit Score: 46.15  E-value: 4.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  94 FGLAMGSFALGTLLAALSPSFAILLVARVIQAFGSAIMLpLLMTTILTLVPKQR-RGLVMGNVSIVISVAPALGPTISGV 172
Cdd:cd17322    70 FLVSLLLYVVGTIIMAASTNVQTYAAGSVFYNAGYTGLN-LLLTLILADFSSLKnRGFASAIPSLPYIITTWIGGNIAQA 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 173 ILNHFPWR---SIFWFVLPIAVLALIIGLT-------------RLKDVGSRGDLR------------LDVLSVVLSVFGF 224
Cdd:cd17322   149 ALPNSNWRwgyGMWAIILPLSSLPLVLCLLymqrkarkdgeikELKNQETEEQTGglsqnlvklfwkLDIFGVILLTAGL 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 225 GLLVHGLSTVGaGGTQGDDSDSFMGwatsagggavILMLGVLLVAAFALRQLQLQRknNPFLDLRTFKHRDFTVSVALMA 304
Cdd:cd17322   229 GLILVPLTLAG-GAKSKWKNSSIIA----------MIVLGGVLLVAFLLWEAKFAK--YPFLPFRLLKDRTILAACLIDF 295

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 305 VAMMTLFGGVIVLPLYLQTIRGLDTLQTGLILLPGGLIMGLLGPVIGRLFDAFG-PRPLAVPGAALLTFVMFNFSRL-QA 382
Cdd:cd17322   296 FYFFSYYIFSDYLYTVLQVAVGESITSATRITNLYSFVSTVAGIFVGFLIRKTRrYKVLVIIGVPLYIVGMGLLIRYrGG 375

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2791517158 383 DTAVWWIVTLQIAMSVGLAMIFTPAFTSGLNPLPPKLYSHGSATLSTLQQVAGAAGTA 440
Cdd:cd17322   376 SGSHGGIIGALILIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSIGGAVGAA 433
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 52-208 5.34e-05

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 45.34  E-value: 5.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  52 LMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAALSPS-FAILLVARVIQAFGSAI 130
Cdd:cd17355    29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSlWQLYLLWGLLGGGGAGT 108

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2791517158 131 MLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIF-WFVLPIAVLALIIGLTRLKDVGSRG 208
Cdd:cd17355   109 LAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALlVLALLALLVLVPVLLLLRRRPADLA 187
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 5-196 6.59e-05

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 45.23  E-value: 6.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158   5 PSQPASGGTAEHPPQTAPGAMGTIAVLLIAAFVVI-LNETILNVALP-HLMEDLHVdaaTVQWVATAFMLTMAVVIPT-- 80
Cdd:cd17471   177 PSVKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLfAANSMYIIAMPlYVTNELGG---SESWVGLLFGLAAALEIPIml 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  81 -TGFLLQKVSTRAVFGLAMGSFALGTLLAALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQrRGLVMGNVSIVI 159
Cdd:cd17471   254 lAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLMPGQ-PGLATTLYSNAS 332

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2791517158 160 SVAPALGPTISGVILNHFPWRSIFWFVLPIAVLALII 196
Cdd:cd17471   333 RIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVL 369
MFS_UhpC cd17488
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ...
 46-203 9.96e-05

Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341041 [Multi-domain]  Cd Length: 364  Bit Score: 44.70  E-value: 9.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  46 NVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAALSPSFAILLVARVIQA 125
Cdd:cd17488    23 NAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFSSSLWAFAVLWTLNA 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2791517158 126 FGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVLPIAVLALIIGLTRLKD 203
Cdd:cd17488   103 FFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGMYVPGIIAILMGIVLCWRLRD 180
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 44-195 9.97e-05

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 44.60  E-value: 9.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  44 ILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAALSPSFAILLVARVI 123
Cdd:cd17371    17 LLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRAL 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2791517158 124 QAFGSAIMLPLLMTTILTLVPKQRR----GLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWF-VLPIAVLALI 195
Cdd:cd17371    97 AGLGFGGEWAAGAALMAEYVPARHRgkalGYVQSGWAVGWLLATLLAALLFPLLPPEIAWRVLFLLgALPALLVLFI 173
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 63-196 1.26e-04

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 44.11  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  63 VQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAALSPSFAILLVARVIQAFGSAIMLPLLMTTILTL 142
Cdd:cd17317    27 VALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEI 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2791517158 143 VPKQRRGLvmgnVSIVISVAPALGPTISGVILNHFP-WRSIFWFV-LPIAVLALII 196
Cdd:cd17317   107 VGPKYRSF----VGILFGLFWALGYMLLALLAYLIRdWRWLQLAIsLPGLLFLLLL 158
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 45-203 1.69e-04

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 43.80  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  45 LNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAALSPSFAILLVARVIQ 124
Cdd:cd17312    22 FSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLN 101

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2791517158 125 AFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVLPIAVLALIIGLTRLKD 203
Cdd:cd17312   102 GLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRD 180
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
 5-196 2.21e-04

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 43.40  E-value: 2.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158   5 PSQPASGGTAEHPPQTAPGAMGTIAVLLI---AAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTT 81
Cdd:cd17393   176 PGTGEAAEDRPDGAGKPGFLLPNRLLLLLgllALAAALAEGAAADWSALYLRDVLGASAALAALGYAVFSLAMTVGRLFG 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  82 GFLLQKVSTRAVFGLAMGSFALGTLLAALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLvPKQRRGLVMGNVSIVISV 161
Cdd:cd17393   256 DRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAGAL-PGLAAGIAVARVATLGYL 334

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 2791517158 162 APALGPTISGVILNHFPWRSIFWFVLPIAVLALII 196
Cdd:cd17393   335 GFLVGPPLIGFLADATGLRTAFLVVALLALLVALL 369
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 31-196 2.42e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 43.37  E-value: 2.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  31 LLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAV-----FGLAMGSFALGT 105
Cdd:cd06173     4 LWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAVLAL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 106 LLAALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWF 185
Cdd:cd06173    84 LALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAI 163

                         170
                  ....*....|.
gi 2791517158 186 VLPIAVLALII 196
Cdd:cd06173   164 NALSFLLSALL 174
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 31-198 2.44e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 43.37  E-value: 2.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  31 LLIAAFVVILNETIL---NVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLL 107
Cdd:cd17353     5 VLLGAVLMHLILGYQyawSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFIL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 108 AALSPSFAIL-LVARVIQAFGSAIMLPLLMTTILTLVPkQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFwFV 186
Cdd:cd17353    85 SAFAISLPLLfLGYGVLGGIGAGIGYITPVSTAVKWFP-DKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTF-LI 162

                         170
                  ....*....|..
gi 2791517158 187 LPIAVLALIIGL 198
Cdd:cd17353   163 LGIIFLIIIVIG 174
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 31-205 2.46e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 43.34  E-value: 2.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  31 LLIAAFVVILNETILNVALPHLMEDLHVDAAT---VQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLL 107
Cdd:cd17330     1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASgyyVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 108 AALSPSFAILLVARVIQAFGSAiMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVL 187
Cdd:cd17330    81 LGLSRNLWLLFLARFLDGLTGG-NVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAA 159

                         170
                  ....*....|....*...
gi 2791517158 188 PIAVLALIIGLTRLKDVG 205
Cdd:cd17330   160 ALALLNLVLVLFFLPPLR 177
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 70-198 3.20e-04

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 43.02  E-value: 3.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  70 FMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAALSPS----FAILLVARVIQAFGSAIMLPLLMTTILTLVPK 145
Cdd:cd17476   221 MAIGGVLAAITVGFLIARLPPSYIMAISMVAFLVGPILFATMPVhqtyWAQAFPAMIVAPFGMDFSFPAATIIASNAVPR 300

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2791517158 146 QRRGLVMGNVSIVISVAPALGPTISGVILNHFP---------WRSIFWFVLPIAVLALIIGL 198
Cdd:cd17476   301 EYQGLAGSLVNTVVNYGISIGLGIAGTVETSVNedgadllkgYRAAWYLGIGLAALGLLISV 362
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 270-406 7.53e-04

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 41.74  E-value: 7.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 270 AFALRQLQLQRKNNPFLDLRTFKHRDFTVSVALMAVAMMTLFGGVIVLPLYLQTIRGLDTLQTGLILLPGGLIMGLLGPV 349
Cdd:cd17369   204 VFRRAKEAGQVVRAPLVEVLRRHWRALLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPL 283

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2791517158 350 IGRLFDAFGPRPLAVPGAALLTFVMFNFSRLQADTAVWWIV-TLQIAMSVGLAMIFTP 406
Cdd:cd17369   284 FGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGSTWLIVlAAVVVLGVLHGMMYGP 341
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 102-198 7.78e-04

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 41.82  E-value: 7.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 102 ALGTLLAALSPSFAILLVARVIQAFGSAiMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRS 181
Cdd:cd17490    73 VLASLIMILFPSPWGLLIARFLSGIAAA-TWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRA 151

                          90
                  ....*....|....*..
gi 2791517158 182 IFWFVLPIAVLALIIGL 198
Cdd:cd17490   152 PFLLAALAGVLGFILSL 168
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 47-196 8.42e-04

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 41.84  E-value: 8.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  47 VALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAALSPSFAILLVARVIQAF 126
Cdd:cd17475    17 ALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGA 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 127 GSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFWFVLPIAVLALII 196
Cdd:cd17475    97 GYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVL 166
MFS_NIMT_CynX_like cd17339
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ...
 28-202 1.08e-03

2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340897 [Multi-domain]  Cd Length: 374  Bit Score: 41.41  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  28 IAVLLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLL 107
Cdd:cd17339     1 ILGIVLIAFNLRPAITSVGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 108 AALSPSFAiLLVARVIQAFGSAIMLPLLMTTILTLVPKqRRGLVMGNVSIVISVAPALGPTISGVILNHFP--WR-SIFW 184
Cdd:cd17339    81 RSLGGIAL-LFLGTALAGAGIAVGNVLLPSLIKRDFPR-RVGLMTGLYTTSMNLGAALASGLSVPLAQALGggWRgALAI 158

                         170
                  ....*....|....*...
gi 2791517158 185 FVLPiAVLALIIGLTRLK 202
Cdd:cd17339   159 WALP-ALLALLIWLPQLR 175
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 82-197 2.17e-03

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 40.29  E-value: 2.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  82 GFLLQKVSTRAVFGLAMGSFALGTLL--AALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVI 159
Cdd:cd17318    77 GYLAEKYGAKRVLGYSILITALLTLLtpLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGS 156

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2791517158 160 SVAPALGPTISGVILNHFPWRSIF-------------WFVLPIAVLALIIG 197
Cdd:cd17318   157 QFGTVIAMPLSGFLCESLGWPSIFyifgglgllwcllWFFLVLPVWAIVVA 207
PRK03545 PRK03545
putative arabinose transporter; Provisional
 30-198 2.27e-03

putative arabinose transporter; Provisional


Pssm-ID: 179591 [Multi-domain]  Cd Length: 390  Bit Score: 40.26  E-value: 2.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  30 VLLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAA 109
Cdd:PRK03545   13 TLALAAFIFNTTEFVPVGLLSDIAQSFHMQTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGLFVLFIASHVLSA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 110 LSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWRSIFwfvLPI 189
Cdd:PRK03545   93 LAWNFTVLLISRIGIAFAHAIFWSITASLAIRVAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGWRTTF---LAI 169


                  ....*....
gi 2791517158 190 AVLALIIGL 198
Cdd:PRK03545  170 GGGALITLL 178
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 101-421 2.76e-03

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 40.07  E-value: 2.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 101 FALGTLLAALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISGVILNHFPWR 180
Cdd:PRK03893   95 FSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWR 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 181 SIFWF-VLPIAV-LALIIGLTRLKD----VGSRGDLR--LDVL--------SVVLSVFGFGLLVHglstvgaggtqgdds 244
Cdd:PRK03893  175 ALFFIgILPIIFaLWLRKNLPEAEDwkekHAGKAPVRtmVDILyrgehriiNILLTLAAAAALWF--------------- 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 245 dSFMGWATSaggGAVILMLGVLLVAAFALRQLQLQRKNNPfldlrtfkhrdftVSVALMAVAMMT-LFGGVI--VLPLYL 321
Cdd:PRK03893  240 -CFAGNLQN---AAIVAVLGLLCAAIFISFMVQSSGKRWP-------------TGVMLMVVVLFAfLYSWPIqaLLPTYL 302

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 322 QTIRGLDTLQTGLILLPGGLIMGLLGPVIGRLFDAFGPRPLAVPGAALLTFVMFNFSRLQADTAVWwivtlqiamsVGLA 401
Cdd:PRK03893  303 KTDLGYDPHTVANVLFFSGFGAAVGCCVGGFLGDWLGTRKAYVCSLLISQLLIIPVFAIGGANVWV----------LGLL 372

                         330       340
                  ....*....|....*....|
gi 2791517158 402 MIFTPAFTSGLNPLPPKLYS 421
Cdd:PRK03893  373 LFFQQMLGQGISGLLPKLIG 392
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 1-177 3.56e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 39.56  E-value: 3.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158   1 MPSSPSQPASGGTAEHPPQTAPGAMGT--IAVLLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVI 78
Cdd:cd17355   183 PADLALRAYDDASPASPGSTLKEALRSasFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGR 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  79 PTTGFLLQKVSTRAVFGLAMGSFALGT-LLAALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSI 157
Cdd:cd17355   263 LLSGWLGDRYSPRRLLAASYALRALGLaLLLLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFA 342

                         170       180
                  ....*....|....*....|
gi 2791517158 158 VISVAPALGPTISGVILNHF 177
Cdd:cd17355   343 PHQLGSALGPWLGGLLYDRT 362
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
 49-153 4.95e-03

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 39.21  E-value: 4.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  49 LPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAALSPSFAILLVARVIQAFGS 128
Cdd:cd06180    22 LPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAAS 101

                          90       100
                  ....*....|....*....|....*
gi 2791517158 129 AIMLPLLMTTILTLVPKQRRGLVMG 153
Cdd:cd06180   102 AFVFVFGSNLVLHHATAAGRGHLIG 126
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 300-498 6.82e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 38.71  E-value: 6.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 300 VALMAVAMMTLFGGVI-VLPLYLQTIrGLDTLQTGLILLPGGLIMGLLGPVIGRLFDAFGPRPLAVPGAALLTFVMFNFS 378
Cdd:cd17325     1 LSLALFLDMLGYGIIIpILPLYAESL-GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 379 rlqADTAVWWIVTLQIAMSVGLAMIFTPAFTsglnplppklYSHGSATLSTLQQVAGAAGTALLVGIMqAGTTVlqnpdG 458
Cdd:cd17325    80 ---FATSYWQLLLARFLQGLASAAVWPAAMA----------LIADIAPPEERGRAMGIFSSAIGLGFL-IGPLL-----G 140

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2791517158 459 STTTDAIpGVHAAFLTATALGVVAFVLTLFMRKATPENTR 498
Cdd:cd17325   141 GLLADAL-GYRAPFLVCAALALLALVLALLLLPEPRPPPN 179
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
48-200 7.16e-03

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 38.77  E-value: 7.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  48 ALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTRAVFGLAMGSFALGTLLAALSPSFAILLVARVIQAFG 127
Cdd:PRK15402   35 GMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIG 114

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2791517158 128 ----SAIMLPLLMTTILTLVPKQRRGLvMGNVSIVisvAPALGPTISGVILNHFPWRSIFWFvlpIAVLALI--IGLTR 200
Cdd:PRK15402  115 lcfiGAVGYAAIQESFEEADAIKITAL-MANVALL---APLLGPLVGAALIHVLPWRGMFVL---FAALAALsfFGLWR 186
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
303-502 7.89e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 38.73  E-value: 7.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 303 MAVAMMTLFGGVIvLPLYLQTIRGLDTLQTGLILLPGGLIMGLLGPVIGRLFDAFGPRP--------LAVPGAALLTFVM 374
Cdd:COG2211    20 LGLNLAFGLLSAY-LLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpwilIGAIPLALSFVLL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158 375 FNFSRLQADTAVWWIVTLQIAMSVGLAMIFTPaftsgLNPLPPKLYSHGS--ATLSTLQQVAGAAGTAllvgIMQAGTTV 452
Cdd:COG2211    99 FTAPDLSPTGKLIYALVTYLLLGLAYTLVNIP-----YSALGAELTPDYEerTRLSSWRFAFAGLGGL----LASVLPPP 169

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2791517158 453 LQNPDGSTTTDAIpgvhaaFLTATALGVVAFVLTLFMRKATPENTRVTVE 502
Cdd:COG2211   170 LVAAFGGDAALGY------RLTALIFAVLGLLAFLLTFFGTKERPVPEEE 213
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 12-196 8.24e-03

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 38.40  E-value: 8.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  12 GTAEHPPQTAPGAMGTIAVLLIAAFVVILNETILNVALPHLMEDLHVDAATVQWVATAFMLTMAVVIPTTGFLLQKVSTR 91
Cdd:PRK11551    1 MSTRTSSASSSRLALTIGLCFLVALLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2791517158  92 AVFGLAMGSFALGTLLAALSPSFAILLVARVIQAFGSAIMLPLLMTTILTLVPKQRRGLVMGNVSIVISVAPALGPTISG 171
Cdd:PRK11551   81 RILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGV 160

                         170       180
                  ....*....|....*....|....*..
gi 2791517158 172 VILNHFPWRSIFWF--VLPIAVLALII 196
Cdd:PRK11551  161 LAAGDAAWRHIFYVggVGPLLLVPLLM 187
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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