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Conserved domains on  [gi|2793906751|ref|WP_372081057|]
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IS66 family insertion sequence element accessory protein TnpB, partial [Vibrio sp. 10N.261.46.A3]

Protein Classification

transposase family protein( domain architecture ID 1000323)

transposase family protein may bind to the end of a transposon and catalyzes the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism; similar to IS66 family insertion sequence element accessory protein TnpB

Gene Ontology:  GO:0003677|GO:0032196|GO:0015074|GO:0006310|GO:0004803
PubMed:  20215432|11774877|20079432|11418571

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TnpB_IS66 super family cl29265
IS66 Orf2 like protein; This protein is found in insertion sequences related to IS66. The ...
 10-63 8.50e-25

IS66 Orf2 like protein; This protein is found in insertion sequences related to IS66. The function of these proteins is uncertain, but they are probably essential for transposition.


The actual alignment was detected with superfamily member NF033819:

Pssm-ID: 475172  Cd Length: 90  Bit Score: 87.54  E-value: 8.50e-25
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 2793906751 10 IYLYRESVDFRKSINGLAAIIESDTDLPLGSGALFLFTNKQRDKIKVLYWDKTG 63
Cdd:NF033819   1 IYLATGPTDMRKGIDGLAALVQEVLGLDPFSGHLFVFRNRRRDRLKILYWDGSG 54
 
Name Accession Description Interval E-value
IS66_TnpB NF033819
IS66 family insertion sequence element accessory protein TnpB; The IS66 family insertion ...
 10-63 8.50e-25

IS66 family insertion sequence element accessory protein TnpB; The IS66 family insertion sequence element encodes a DDE transposase TnpC, and two accessory proteins, TnpA and TnpB. It has been assumed that the TnpA, TnpB, and TnpC proteins are produced independently in appropriate amounts and form a complex, which acts as a transposase to promote the transposition of an IS66 family element.


Pssm-ID: 411392  Cd Length: 90  Bit Score: 87.54  E-value: 8.50e-25
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 2793906751 10 IYLYRESVDFRKSINGLAAIIESDTDLPLGSGALFLFTNKQRDKIKVLYWDKTG 63
Cdd:NF033819   1 IYLATGPTDMRKGIDGLAALVQEVLGLDPFSGHLFVFRNRRRDRLKILYWDGSG 54
TnpB_IS66 pfam05717
IS66 Orf2 like protein; This protein is found in insertion sequences related to IS66. The ...
 13-63 3.24e-22

IS66 Orf2 like protein; This protein is found in insertion sequences related to IS66. The function of these proteins is uncertain, but they are probably essential for transposition.


Pssm-ID: 461723  Cd Length: 96  Bit Score: 80.98  E-value: 3.24e-22
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 2793906751 13 YRESVDFRKSINGLAAIIESDTDLPLGSGALFLFTNKQRDKIKVLYWDKTG 63
Cdd:pfam05717  1 ATGPTDMRKGIDGLAALVQEALGLDPFSGHLFVFRNRRRDRIKILYWDGDG 51
COG3436 COG3436
Transposase [Mobilome: prophages, transposons];
15-63 7.04e-05

Transposase [Mobilome: prophages, transposons];


Pssm-ID: 442662 [Multi-domain]  Cd Length: 416  Bit Score: 38.09  E-value: 7.04e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2793906751  15 ESVDFRKsINGLAAIIESDT---DLPlgSGALFLFTNkQRDKIKVLYWDKTG 63
Cdd:COG3436    82 EPTDMRK-IDGLAAIGEEVSeelDLD--PGALFVFRN-RRDKYKCLYCDGTG 129
 
Name Accession Description Interval E-value
IS66_TnpB NF033819
IS66 family insertion sequence element accessory protein TnpB; The IS66 family insertion ...
 10-63 8.50e-25

IS66 family insertion sequence element accessory protein TnpB; The IS66 family insertion sequence element encodes a DDE transposase TnpC, and two accessory proteins, TnpA and TnpB. It has been assumed that the TnpA, TnpB, and TnpC proteins are produced independently in appropriate amounts and form a complex, which acts as a transposase to promote the transposition of an IS66 family element.


Pssm-ID: 411392  Cd Length: 90  Bit Score: 87.54  E-value: 8.50e-25
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 2793906751 10 IYLYRESVDFRKSINGLAAIIESDTDLPLGSGALFLFTNKQRDKIKVLYWDKTG 63
Cdd:NF033819   1 IYLATGPTDMRKGIDGLAALVQEVLGLDPFSGHLFVFRNRRRDRLKILYWDGSG 54
TnpB_IS66 pfam05717
IS66 Orf2 like protein; This protein is found in insertion sequences related to IS66. The ...
 13-63 3.24e-22

IS66 Orf2 like protein; This protein is found in insertion sequences related to IS66. The function of these proteins is uncertain, but they are probably essential for transposition.


Pssm-ID: 461723  Cd Length: 96  Bit Score: 80.98  E-value: 3.24e-22
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 2793906751 13 YRESVDFRKSINGLAAIIESDTDLPLGSGALFLFTNKQRDKIKVLYWDKTG 63
Cdd:pfam05717  1 ATGPTDMRKGIDGLAALVQEALGLDPFSGHLFVFRNRRRDRIKILYWDGDG 51
COG3436 COG3436
Transposase [Mobilome: prophages, transposons];
15-63 7.04e-05

Transposase [Mobilome: prophages, transposons];


Pssm-ID: 442662 [Multi-domain]  Cd Length: 416  Bit Score: 38.09  E-value: 7.04e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2793906751  15 ESVDFRKsINGLAAIIESDT---DLPlgSGALFLFTNkQRDKIKVLYWDKTG 63
Cdd:COG3436    82 EPTDMRK-IDGLAAIGEEVSeelDLD--PGALFVFRN-RRDKYKCLYCDGTG 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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