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Conserved domains on  [gi|2793953899|ref|WP_372116302|]
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IS66 family transposase zinc-finger binding domain-containing protein, partial [Vibrio sp. 10N.261.51.E5]

Protein Classification

IS66 family transposase( domain architecture ID 15980350)

IS66 family transposase binds to the end of a transposon and catalyze the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism

Gene Ontology:  GO:0004803|GO:0032196|GO:0003677
PubMed:  20615441|17165262|20079432

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
transpos_IS66 super family cl41296
IS66 family transposase; Members of this protein family are DDE transposases from the IS66 ...
 63-158 3.43e-28

IS66 family transposase; Members of this protein family are DDE transposases from the IS66 family insertion sequences, which typically consist of two accessary genes (TnpA and TnpB) and the third gene encoding the transposase.


The actual alignment was detected with superfamily member NF033517:

Pssm-ID: 468053 [Multi-domain]  Cd Length: 388  Bit Score: 107.28  E-value: 3.43e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793953899  63 PLPKTLPREVIELDVDdhekQCACCNHS-LHKIGEDRSEKLEFTPAVLKVLEYVRPKYACRQCEKtgdssrIVQKPSPQS 141
Cdd:NF033517   11 PLPDHLPREEVVHEPE----SCPCCGGAlLHRIGEEVSEQLEIIPAKFEVTEYVRPKYACRHCGT------VVQAPAPAR 80

                          90
                  ....*....|....*..
gi 2793953899 142 LIPKSFATESLLTNIIL 158
Cdd:NF033517   81 VIPKGQAGPRLLAHVAV 97
LZ_Tnp_IS66 pfam13007
Transposase C of IS166 homeodomain; This is a leucine-zipper-like or homeodomain-like region ...
 4-73 1.35e-03

Transposase C of IS166 homeodomain; This is a leucine-zipper-like or homeodomain-like region of transposase TnpC of insertion element IS66.


:

Pssm-ID: 463771 [Multi-domain]  Cd Length: 67  Bit Score: 35.32  E-value: 1.35e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793953899   4 LLEQLKLAFDRQFAKRSEALkpyDESQGDLFnEAECEAVKEDEVEVTTTTTTKKRGKRKPLPKTLPREVI 73
Cdd:pfam13007   2 LEEQLALLKRRLFGRSSEKL---DPEQLELA-LEELEAEEAEVEAEARASKKRKKPGRKPLPAHLPREEV 67
 
Name Accession Description Interval E-value
transpos_IS66 NF033517
IS66 family transposase; Members of this protein family are DDE transposases from the IS66 ...
 63-158 3.43e-28

IS66 family transposase; Members of this protein family are DDE transposases from the IS66 family insertion sequences, which typically consist of two accessary genes (TnpA and TnpB) and the third gene encoding the transposase.


Pssm-ID: 468053 [Multi-domain]  Cd Length: 388  Bit Score: 107.28  E-value: 3.43e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793953899  63 PLPKTLPREVIELDVDdhekQCACCNHS-LHKIGEDRSEKLEFTPAVLKVLEYVRPKYACRQCEKtgdssrIVQKPSPQS 141
Cdd:NF033517   11 PLPDHLPREEVVHEPE----SCPCCGGAlLHRIGEEVSEQLEIIPAKFEVTEYVRPKYACRHCGT------VVQAPAPAR 80

                          90
                  ....*....|....*..
gi 2793953899 142 LIPKSFATESLLTNIIL 158
Cdd:NF033517   81 VIPKGQAGPRLLAHVAV 97
COG3436 COG3436
Transposase [Mobilome: prophages, transposons];
1-158 6.56e-28

Transposase [Mobilome: prophages, transposons];


Pssm-ID: 442662 [Multi-domain]  Cd Length: 416  Bit Score: 107.04  E-value: 6.56e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793953899   1 RQSLLEQLKLAFDRQFAKRSEALKPYDESQGDLFNEAECEAVKEDEVEVTTTTTTKKRGKRKPLPKTLPREVIELDVDDH 80
Cdd:COG3436     7 LILLLLLLERLRLRRLRERESRLESQPELQLLELEEEAEEEEEAAEEAEAKTTKKKPKPGRKPMPEHLPREEVLHEPTDM 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2793953899  81 EKQcaccnHSLHKIGEDRSEKLEFTPAVLKVLEYVRPKYACRQCEKTGdssrIVQKPSPQSLIPKSFATESLLTNIIL 158
Cdd:COG3436    87 RKI-----DGLAAIGEEVSEELDLDPGALFVFRNRRDKYKCLYCDGTG----LVYAPAPAKRLEKGLAGPGLLAHILV 155
zf-IS66 pfam13005
zinc-finger binding domain of transposase IS66; This is a zinc-finger region of the N-terminus ...
 81-125 2.59e-15

zinc-finger binding domain of transposase IS66; This is a zinc-finger region of the N-terminus of the insertion element IS66 transposase.


Pssm-ID: 463770 [Multi-domain]  Cd Length: 46  Bit Score: 65.80  E-value: 2.59e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2793953899  81 EKQCACCNHSLHKIGEDR-SEKLEFTPAVLKVLEYVRPKYACRQCE 125
Cdd:pfam13005   1 ERVCPCCGGLLHPIGEDEvREELDIPPAKFRVIEHIRPKYACRHCE 46
LZ_Tnp_IS66 pfam13007
Transposase C of IS166 homeodomain; This is a leucine-zipper-like or homeodomain-like region ...
 4-73 1.35e-03

Transposase C of IS166 homeodomain; This is a leucine-zipper-like or homeodomain-like region of transposase TnpC of insertion element IS66.


Pssm-ID: 463771 [Multi-domain]  Cd Length: 67  Bit Score: 35.32  E-value: 1.35e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793953899   4 LLEQLKLAFDRQFAKRSEALkpyDESQGDLFnEAECEAVKEDEVEVTTTTTTKKRGKRKPLPKTLPREVI 73
Cdd:pfam13007   2 LEEQLALLKRRLFGRSSEKL---DPEQLELA-LEELEAEEAEVEAEARASKKRKKPGRKPLPAHLPREEV 67
 
Name Accession Description Interval E-value
transpos_IS66 NF033517
IS66 family transposase; Members of this protein family are DDE transposases from the IS66 ...
 63-158 3.43e-28

IS66 family transposase; Members of this protein family are DDE transposases from the IS66 family insertion sequences, which typically consist of two accessary genes (TnpA and TnpB) and the third gene encoding the transposase.


Pssm-ID: 468053 [Multi-domain]  Cd Length: 388  Bit Score: 107.28  E-value: 3.43e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793953899  63 PLPKTLPREVIELDVDdhekQCACCNHS-LHKIGEDRSEKLEFTPAVLKVLEYVRPKYACRQCEKtgdssrIVQKPSPQS 141
Cdd:NF033517   11 PLPDHLPREEVVHEPE----SCPCCGGAlLHRIGEEVSEQLEIIPAKFEVTEYVRPKYACRHCGT------VVQAPAPAR 80

                          90
                  ....*....|....*..
gi 2793953899 142 LIPKSFATESLLTNIIL 158
Cdd:NF033517   81 VIPKGQAGPRLLAHVAV 97
COG3436 COG3436
Transposase [Mobilome: prophages, transposons];
1-158 6.56e-28

Transposase [Mobilome: prophages, transposons];


Pssm-ID: 442662 [Multi-domain]  Cd Length: 416  Bit Score: 107.04  E-value: 6.56e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793953899   1 RQSLLEQLKLAFDRQFAKRSEALKPYDESQGDLFNEAECEAVKEDEVEVTTTTTTKKRGKRKPLPKTLPREVIELDVDDH 80
Cdd:COG3436     7 LILLLLLLERLRLRRLRERESRLESQPELQLLELEEEAEEEEEAAEEAEAKTTKKKPKPGRKPMPEHLPREEVLHEPTDM 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2793953899  81 EKQcaccnHSLHKIGEDRSEKLEFTPAVLKVLEYVRPKYACRQCEKTGdssrIVQKPSPQSLIPKSFATESLLTNIIL 158
Cdd:COG3436    87 RKI-----DGLAAIGEEVSEELDLDPGALFVFRNRRDKYKCLYCDGTG----LVYAPAPAKRLEKGLAGPGLLAHILV 155
zf-IS66 pfam13005
zinc-finger binding domain of transposase IS66; This is a zinc-finger region of the N-terminus ...
 81-125 2.59e-15

zinc-finger binding domain of transposase IS66; This is a zinc-finger region of the N-terminus of the insertion element IS66 transposase.


Pssm-ID: 463770 [Multi-domain]  Cd Length: 46  Bit Score: 65.80  E-value: 2.59e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2793953899  81 EKQCACCNHSLHKIGEDR-SEKLEFTPAVLKVLEYVRPKYACRQCE 125
Cdd:pfam13005   1 ERVCPCCGGLLHPIGEDEvREELDIPPAKFRVIEHIRPKYACRHCE 46
LZ_Tnp_IS66 pfam13007
Transposase C of IS166 homeodomain; This is a leucine-zipper-like or homeodomain-like region ...
 4-73 1.35e-03

Transposase C of IS166 homeodomain; This is a leucine-zipper-like or homeodomain-like region of transposase TnpC of insertion element IS66.


Pssm-ID: 463771 [Multi-domain]  Cd Length: 67  Bit Score: 35.32  E-value: 1.35e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793953899   4 LLEQLKLAFDRQFAKRSEALkpyDESQGDLFnEAECEAVKEDEVEVTTTTTTKKRGKRKPLPKTLPREVI 73
Cdd:pfam13007   2 LEEQLALLKRRLFGRSSEKL---DPEQLELA-LEELEAEEAEVEAEARASKKRKKPGRKPLPAHLPREEV 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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