|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
6-390 |
3.75e-100 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 302.65 E-value: 3.75e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 6 FPLLVWLGIGTLIISLGIRQSFGIFMMPISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGL 85
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 86 GLLLTSISTESSMLYVSLGALIGLGLSATSYVIVLGAVAKVvPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQS 165
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWW-FERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 166 AMQVFGVLCCLMISFALFMRAPKAASNKQAQA--EENQTLKEALSEAFAHKGYWLIHAGFFVCGFHVMFIATHLPSYLAD 243
Cdd:cd17355 160 ALLVLALLALLVLVPVLLLLRRRPADLALRAYddASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLAD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 244 KDLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIGAFVTLPVTESTAAIFGAAIGFCWLGTVPL 323
Cdd:cd17355 240 RGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPL 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2793981667 324 TSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVLAFAAALIHLPI 390
Cdd:cd17355 320 TAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
8-388 |
6.81e-50 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 172.76 E-value: 6.81e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 8 LLVWLGIGTLIISLGIRQSFGIFMMPISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGL 87
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 88 LLTSISTESSMLYVsLGALIGLGLsATSYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAM 167
Cdd:COG2223 85 LLLALAVSYWLLLL-LGLLLGIGG-GGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 168 QVFGVLCCLM-ISFALFMRAPKAASNKQAQAEENqtlkeALSEAFAHKGYWLIHAGFFVCGFHVMFIATHLPSYLADK-D 245
Cdd:COG2223 163 LILGILLLVVaVLAWLFLRDPPAGAAAAAKASLR-----DQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQfG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 246 LPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIGAFVTLPVTESTAAIFGAAIGFCWLGTVPLTS 325
Cdd:COG2223 238 LSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVF 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2793981667 326 GLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVLAFAAALIHL 388
Cdd:COG2223 318 ALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTL 380
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
7-386 |
5.81e-35 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 132.73 E-value: 5.81e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 7 PLLVWLGIGTLIISLGIRQSFGIFMMPISEHFGTGR--EFFSFSIALqnLLFGVFQPFVGMAADKWGARRIIIAGACAYG 84
Cdd:cd17353 2 RWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLasVALAFTLTI--VFLAISAPFAGRLVDRGGPRKAILIGGILFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 85 LGLLLTSISTESSMLYVSLGALIGLGLSATsYVIVLGAVAKVVPaEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQ 164
Cdd:cd17353 80 LGFILSAFAISLPLLFLGYGVLGGIGAGIG-YITPVSTAVKWFP-DKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 165 SAMQVFGVLCCLMISF-ALFMRAPK-----AASNKQAQAEENQTLKEALSEAFAHKGYWLIHAGFFVCGFHVMFIATHLP 238
Cdd:cd17353 158 TTFLILGIIFLIIIVIgAFLIRDPPkgwvpPGVDPLANNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 239 SYLADKD-LPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIGAFVTLPVTESTAAIFGAAIGFCW 317
Cdd:cd17353 238 PIGQEFAgLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCY 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2793981667 318 LGTVPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVLAFAAALI 386
Cdd:cd17353 318 GGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALA 386
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
16-388 |
1.18e-31 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 123.68 E-value: 1.18e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 16 TLIISLGIRQSFGIFMMPISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTE 95
Cdd:cd17314 11 LSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSYVFN 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 96 SSMLYVSLGALIGLGLSATsYVIVLGAVAKVVPaEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVLCC 175
Cdd:cd17314 91 SFPLSYACFVFIGAGTGIL-YGSAVLVTTQYFP-DTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGILAA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 176 LMISFALFMRaPKAASNKQAQAEENQTLKEALSEAFAHKGYWLIHA---GFFVCGFHVMFIATHLPSYLadKDLPASSAA 252
Cdd:cd17314 169 IVLSVVSLLG-FKEPPDNQARLHVQKKKTQTMGEIFRDKVFWILFIaifLVLIGGFLFIANMASLVRSL--QLDAPSFVT 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 253 MALAYVGIFNIFGSYFWGVMGDKFSKRHVM-SALYLVRTVVIGAFVT-LPVTESTAAIFGAAIGFCWLGTVPLTSGLVRQ 330
Cdd:cd17314 246 KLMSIYGLFNAFGRLLWGIVADFFGGRLSTlSILLTILGLGLCAFLFlLKMTPVGLVLTGSLLGFSYGGLFTVYPATVST 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 2793981667 331 IFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVLAFAAALIHL 388
Cdd:cd17314 326 VFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAILL 383
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
16-390 |
2.26e-31 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 122.28 E-value: 2.26e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 16 TLIISLGIRQSFGIFMMPISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTE 95
Cdd:cd17352 11 VNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATS 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 96 SSMLYVSLGALIGLGLS---ATSYVIVLGAVAKvvpaeHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGV 172
Cdd:cd17352 91 LWQLYLTYGVLGGLGLGliySPAIVIVGQYFEK-----KRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGG 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 173 LCCLMISFALFMRapkaasnkqaqaeenqtlkealseAFAHKGYWLIHAG--FFVCGFHVMFIatHLPSYLADKDLPASS 250
Cdd:cd17352 166 LCLNLCVCGLLLR------------------------LLKDPTFVLLALGvsFAMLGFFVPFV--YLPSYAKSLGIDESD 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 251 AAMALAYVGIFNIFGSYFWGVMGDK--FSKRHVMSALYLVRTVVIGAFvTLPVTESTAAIFGAAIGFCWLGTVPLTSGLV 328
Cdd:cd17352 220 AAFLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLILGLSLLAF-PLATTYVGLIVFSVLFGFCSGSYSSLTPVIL 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2793981667 329 RQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVLAFAAALIHLPI 390
Cdd:cd17352 299 ADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLL 360
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
4-390 |
3.17e-31 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 122.29 E-value: 3.17e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 4 FRFPLLVWLGIGTLIISLgIRQSFGIFMMPISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAY 83
Cdd:COG2271 7 YRWRILALLFLAYFLNYL-DRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 84 GLGLLLTSISTESSMLYVSLgALIGLGLSATsYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDW 163
Cdd:COG2271 86 GLATLLFGFATSFWQLLLLR-FLLGLGEAGF-FPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 164 QSAMQVFGVLCCLMISFALfmrapkaasnkqaqaeenqtlkealseafahkgyWLIHAGFFVCGFHVMFIATHLPSYLAD 243
Cdd:COG2271 164 RAAFLILGLPGLLLALLRF----------------------------------WLLALAYFLVYFALYGFLTWLPTYLVE 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 244 -KDLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRH--VMSALYLVRTVVIGAFVTLPvTESTAAIFGAAIGFCWLGT 320
Cdd:COG2271 210 vRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLP-SPALAIALLFLAGFGLGGA 288
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 321 VPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGsYEPIWWSTVVLAFAAALIHLPI 390
Cdd:COG2271 289 FGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLL 357
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
10-386 |
2.10e-30 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 120.36 E-value: 2.10e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 10 VWLGIGTLIISLGIR---QSFGIFMMPISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLG 86
Cdd:COG2807 17 WLLLLAIVLVALNLRpaiTSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 87 LLLTSISTESSMLYVSlGALIGLGLsATSYVIVLGAVAKVVPaEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSA 166
Cdd:COG2807 97 LLLRSLAPSVALLLAG-TALIGAGI-AVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 167 MQVFGVLCCL-MISFALFMRAPKAASNKQAQAeenqtlkEALSEAFAHKGYWLIHAGFFVCGFHVMFIATHLPSYLADKD 245
Cdd:COG2807 174 LAVWALLALLaLLLWLPLLRRRPAAAAAAPAA-------ASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 246 LPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVrtVVIGAFVTLPVTESTAAIFGAA-IGFCWLGTVPLT 324
Cdd:COG2807 247 LSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGL--LGLAGLLGLLLAPGSLPWLWAVlLGLGQGGLFPLA 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2793981667 325 SGLVRQIFG-ARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVLAFAAALI 386
Cdd:COG2807 325 LTLIGLRARtPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVA 387
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
4-352 |
1.38e-27 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 111.60 E-value: 1.38e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 4 FRFPLLVWLGIGTLIISLGIrQSFGIFMMPISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAY 83
Cdd:COG2814 7 RRWLALLALALGAFLSGLGI-GIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 84 GLGLLLTSISTESSMLYVsLGALIGLGlSATSYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDW 163
Cdd:COG2814 86 ALGSLLCALAPSLWLLLA-ARFLQGLG-AGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 164 QSAMQVFGVLCCLMISFALFMRapkaasnKQAQAEENQTLKEALSEAFAHKGYWLIHAGFFVCGFHVMFIATHLPSYLAD 243
Cdd:COG2814 164 RWVFLVNAVLALLALLLLLRLL-------PESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 244 K-DLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIGAFVTLPVTeSTAAIFGAAIGFCWLGTVP 322
Cdd:COG2814 237 VlGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSL-WLLLLALFLLGFGFGLLFP 315
|
330 340 350
....*....|....*....|....*....|
gi 2793981667 323 LTSGLVRQIFGARYLSTLYGLVFFTHQVGS 352
Cdd:COG2814 316 LLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
12-356 |
1.01e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 100.96 E-value: 1.01e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 12 LGIGTLIISLGIRQSFGIFMMPISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTS 91
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 92 ISTESSMLYVsLGALIGLGLSATsYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFG 171
Cdd:pfam07690 81 FASSLWLLLV-LRVLQGLGAGAL-FPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 172 VLCCLMISFALFMRAPKAASNKQAQAEENQTLKEALSEAFAHKGYWLIhAGFFVCGFHVMFIATHLPSYLADKDLPASSA 251
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLL-LALLLFGFAFFGLLTYLPLYQEVLGLSALLA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 252 AMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIGAFVTLPVTESTAAIFGAA--IGFCWLGTVPLTSGLVR 329
Cdd:pfam07690 238 GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALllLGFGFGLVFPALNALVS 317
|
330 340
....*....|....*....|....*..
gi 2793981667 330 QIFGARYLSTLYGLVFFTHQVGSFLGA 356
Cdd:pfam07690 318 DLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| 2A0111 |
TIGR00890 |
oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator ... |
7-390 |
1.26e-20 |
|
oxalate/formate antiporter family transporter; This subfamily belongs to the major facilitator family. Members include the oxalate/formate antiporter of Oxalobacter formigenes, where one substrate is decarboxylated in the cytosol into the other to consume a proton and drive an ion gradient. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273323 [Multi-domain] Cd Length: 377 Bit Score: 92.51 E-value: 1.26e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 7 PLLVWLGIGTLIISLGIRQSFGIFMMPISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLG 86
Cdd:TIGR00890 2 WWYVLVGTVIMCFTSGYVYTWTLLAPPLGRYFGVGVTAVAIWFTLLLIGLAMSMPVGGLLADKFGPRAVAMLGGILYGLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 87 LLLTSISTESSMLYVSLGaLIGLGLSATsYVIVLGAVAKVVPaEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSA 166
Cdd:TIGR00890 82 FTFYAIADSLAALYLTYG-LASAGVGIA-YGIALNTAVKWFP-DKRGLASGIIIGGYGLGSFILSPLITSVINLEGVPAA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 167 MQVFGVLCCLMISF-ALFMR-APKAASNKQAQAEENQTlkeALSEAFAHKGYWLIHAGFFVCGFHVMFIATHLPSYLADK 244
Cdd:TIGR00890 159 FIYMGIIFLLVIVLgAFLIGyPPGQLIKTNIEVSVKDY---TVWEMLRTPQFWVLYLSFFLNAVSGLLLIGLYKPYGQSL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 245 DLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIGAFVTLPVTESTAAIFG-AAIGFCWLGTVPL 323
Cdd:TIGR00890 236 GLSDGFLVLAVSISSIFNGGGRPFLGALSDKIGRQKTMSIVFGISAVGMAAMLFIPMLNDVLFLATvALVFFTWGGTISL 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2793981667 324 TSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGsyepiWWSTVVLAFAAALIHLPI 390
Cdd:TIGR00890 316 FPSLVSDIFGPANSAANYGFLYTAKAVAGIFGGLIASHALTEIG-----FEYTFIVTGAFALTSLAL 377
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
23-386 |
2.00e-20 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 92.10 E-value: 2.00e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 23 IRQSFGIFMMPISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVS 102
Cdd:cd06174 11 ARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 103 LgALIGLGlSATSYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMF--AVIPGAQYMLNEFDWQSAMQVFGVLCCLM-IS 179
Cdd:cd06174 91 R-FLLGLG-SGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGIlgPLLGGILASSLGFGWRAVFLIAAALALLAaIL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 180 FALFMRAPKAASNKQAQAEENQTLKEALSEAFAHKGYWLIHAGFFVCGFHVMFIATHLPSYLADK-DLPASSAAMALAYV 258
Cdd:cd06174 169 LLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLgGLSVAVAGLLLSLF 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 259 GIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIGAFVTLPVTESTAAIFGAAIGFCWLGTVPLTSGLVRQIFGARYLS 338
Cdd:cd06174 249 GLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRG 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 2793981667 339 TLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVLAFAAALI 386
Cdd:cd06174 329 TAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
58-388 |
3.52e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 91.10 E-value: 3.52e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 58 VFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVSLgALIGLGLSATSyVIVLGAVAKVVPAEHAAKAFG 137
Cdd:cd17325 46 LFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLAR-FLQGLASAAVW-PAAMALIADIAPPEERGRAMG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 138 LTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVLCCLMISFALFMRaPKAASNKQAQAEENQTLKEALSEAFAHKGYW 217
Cdd:cd17325 124 IFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLL-PEPRPPPNKRAVSAARLRSGLRLLLRDRRLL 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 218 LIHAGFFVCGFHVMFIATHLPSYLADK-DLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVrTVVIGAF 296
Cdd:cd17325 203 ALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLL-SAVALLL 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 297 VTLPVTESTAAIFGAAIGFCWLGTVPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWST 376
Cdd:cd17325 282 LPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAA 361
|
330
....*....|..
gi 2793981667 377 VVLAFAAALIHL 388
Cdd:cd17325 362 ALLLLAAVLFLL 373
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
5-390 |
9.76e-16 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 78.00 E-value: 9.76e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 5 RFPLLVWLGIGTlIISLGIRQSFGIFMMPISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYG 84
Cdd:cd17319 1 RWRIIPLLFLAY-VINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 85 LGLLLTSISTESSMLYVsLGALIGLGlSATSYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQ 164
Cdd:cd17319 80 LFTALTGFATSLTSLYV-LRFLLGVA-EAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 165 SAMQVFGVLCCLMISFALFMrapkaasnkqaqaeenqtlkealseafaHKGYWLIHAGFFVCGFHVMFIATHLPSYLAD- 243
Cdd:cd17319 158 WAFIIEGLLGLLLAVLWWFY----------------------------LRQVWGLALGYFGINYALYGLLTWLPTYLKQa 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 244 KDLPASSAAMALAYVGIFNIFGSYFWGVMGDKF---SKRHVMSALYLVRTVVIGAFVTLPVTESTAAIFGAAiGFCWLGT 320
Cdd:cd17319 210 RGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrgARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLA-GFGIGAA 288
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 321 VPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVLAFAAALIHLPI 390
Cdd:cd17319 289 SPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
33-388 |
1.47e-15 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 77.59 E-value: 1.47e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 33 PISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVsLGALIGLGLS 112
Cdd:cd17324 24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLL-ARALAGLAHG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 113 ATSYVIVlGAVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVLcCLMISFALFMRAPKAasn 192
Cdd:cd17324 103 GFWAIAA-AYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVL-ALLAALLLWRLLPSL--- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 193 kQAQAEENQTLKEALSEAFAHKGYWLIH-AGFFVCGFHVMFIaTHLPSYLADKD-LPASSAAMALAYVGIFNIFGSYFWG 270
Cdd:cd17324 178 -PPKKPGSLGLLSSLLLLLRNPRLRLAYlITFLLFGGFFALY-TYLAPFLTDVPgFSSSAIIGLLLLFGVAGVVGSPLAG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 271 VMGDKFSKRHVMSALYLVrtVVIGAFVTLPVTESTAAIFGAAI-GFCWLGTVPLTSGLVRQIfGARYLSTLYGLVFFTHQ 349
Cdd:cd17324 256 RLADRGGRRALLIALLLL--AAALLLLTLLGPSPLLLLVGLVLwGLGFFAAHSALQTRVLRL-APEARGLASSLYLAAYN 332
|
330 340 350
....*....|....*....|....*....|....*....
gi 2793981667 350 VGSFLGAWVGGRIYDYYGsYEPIWWSTVVLAFAAALIHL 388
Cdd:cd17324 333 LGGALGAALGGLVLDHGG-WAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
19-369 |
3.68e-14 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 73.19 E-value: 3.68e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 19 ISLGIRQSFGIFMMPISEHF--GTGREFFSFSIALQNLLFGvfQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTES 96
Cdd:cd17423 14 LVFGVLRSFGVFFVEFVEYFeeSAQRVSWITSIGLAVQQLA--SPVGSALSTRYGARPVVMLGGLLSSLGFLLASFATSL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 97 SMLYVSLGALIGLGLsATSYVIVLGAVAKVVPAEHAAkAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVLCCL 176
Cdd:cd17423 92 LHLYLCIGLLSGLGW-ALVFAPTMATVSRYFSRRRSL-ATGLALTGVGLSSFALSPLFQLLLDTYAWRGALLLLSALSLH 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 177 MISFALFMRAPkaasnkqAQAEENQTLKEALSEAFAHKgyWLIHAGFFVCGFHVMFIAT-------HLPSYLADKDLPAS 249
Cdd:cd17423 170 LVPCGALLRPL-------ALPGDPPAPPRSLSAAFGLS--LLTHRAFLRYALATTLINTgyfipyvHLVAHARALGLGEY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 250 SAAMALAYVGIFNIFGSYFWGVMGDKFSKRhVMSALYLVRTVVIGAFVTLPVTESTAAIFGAAI--GFCWLGTVPLTSGL 327
Cdd:cd17423 241 QAAFVVSVAAVADAVGRLFSGWLADLGPLR-LLHLLVLWTALTGLSLLLLPLAKVYGSLLALAVayGFCAGALAPLVFSV 319
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 2793981667 328 VRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSY 369
Cdd:cd17423 320 LPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDY 361
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
58-386 |
6.60e-13 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 69.57 E-value: 6.60e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 58 VFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVSL---GALIGLGLSATSYvivlgAVAKVVPAEHAAK 134
Cdd:cd17475 46 VSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLflvGAGYGSVQPGGGR-----AIMRWFPPRERGL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 135 AFGLTTAAGSFGMF---AVIPgaqYMLNEFDWQSAMQVFGVLCCLM-ISFALFMRAPKAASnkqAQAEENQTLKEALSEA 210
Cdd:cd17475 121 AMGIRQTGVPLGGAlaaALLP---PLALHYGWRAAFVVAGLVSILAaVLFWLFYREPPAAS---AATESASTLLRSLKEV 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 211 FAHKGYWLIH-AGFFVCGFHvMFIATHLPSYLADK-DLPASSAAMALAYVGIFNIFGSYFWGVMGDKF---SKRHVMSAL 285
Cdd:cd17475 195 LRNRDVWLIAiAGALLVAPQ-FALLTFLLLFLHDHlGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVfggRRRPVLVIT 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 286 YLVRTVVIGAFVTLPVTESTAAIFG--AAIGFCWLGTVPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIY 363
Cdd:cd17475 274 AAIAAAALLVLSLLSPGTPLWLLVLllILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLV 353
|
330 340
....*....|....*....|...
gi 2793981667 364 DYYGSYEPIWWSTVVLAFAAALI 386
Cdd:cd17475 354 DATHSYAPAWLALALLLVLAALL 376
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
11-385 |
5.05e-12 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 67.07 E-value: 5.05e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 11 WLGIGTLIISLGIRQSF----GIFMMPISEHFGTGREFFSF--SIALQNLLFGvfQPFVGMAADKWGARRIIIAGACAYG 84
Cdd:TIGR00892 18 WVVLGATFVSIGFSYAFpkavTVFFKELQQIFQATYSETAWisSIMLAVLYAG--GPISSILVNRFGCRPVVIAGGLLAS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 85 LGLLLTSISTESSMLYVSLGALIGLGL--SATSYVIVLGA--VAKVVPAEhaakafGLTTAAGSFGMFAVIPGAQYMLNE 160
Cdd:TIGR00892 96 LGMILASFSSNVIELYLTAGFITGLGLafNFQPSLTMLGKyfYRRRPLAN------GLAMAGSPVFLSTLAPLNQYLFES 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 161 FDWQSAMQVFGVL---CC----LMISFALFMRAPKAASNKQAQAEENQTLKEALSEA-----------FAHKGYWLIHAG 222
Cdd:TIGR00892 170 FGWRGSFLILGGLllhCCvcgaLMRPVGPSQRVSKSKSKEGLPPDGSTKKLSKKSTAekinrfldfslFTHRGFLVYLSG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 223 FFVCGFHVMFIATHLPSYLADKDLPASSAAMALAYVGIFNIFGSYFWGVM-GDKFSKRHV--MSALYLVRTVVIGAFVTL 299
Cdd:TIGR00892 250 NVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIaGLKWIRPHVqyLFSFALLFNGLTHLLCAL 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 300 PVTESTAAIFGAAIGFCWLGTVPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVL 379
Cdd:TIGR00892 330 AGDYTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYASGSI 409
|
....*.
gi 2793981667 380 AFAAAL 385
Cdd:TIGR00892 410 VVSAGL 415
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
58-367 |
8.81e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 66.46 E-value: 8.81e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 58 VFQPFVGMAAD----KWGARR-IIIAGACAYGLGLLLT----SISTESSMLYVsLGALIGLGLSATSYVIVLGA--VAKV 126
Cdd:COG2211 61 ITDPLIGALSDrtrtRWGRRRpWILIGAIPLALSFVLLftapDLSPTGKLIYA-LVTYLLLGLAYTLVNIPYSAlgAELT 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 127 VPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFD------WQSAMQVFGVLCCLMISFALFMrapkaASNKQAQAEEN 200
Cdd:COG2211 140 PDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGgdaalgYRLTALIFAVLGLLAFLLTFFG-----TKERPVPEEEK 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 201 QTLKEALSEAFAHKGYWLIHAGFFVCGFHVMFIATHLPSYLADK-DLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKR 279
Cdd:COG2211 215 VSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKK 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 280 HVMSALYLVRTVVIGAFVTLPVTESTAAIFGAAI-GFCWLGTVPLTSGLV-------RQIFGARYLSTLYGLVFFTHQVG 351
Cdd:COG2211 295 KAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALaGIGLGAILVLPWAMLadvvdydEWKTGRRREGLYFGIFTFAIKLG 374
|
330
....*....|....*.
gi 2793981667 352 SFLGAWVGGRIYDYYG 367
Cdd:COG2211 375 QALAGALAGLLLALFG 390
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
18-185 |
3.46e-11 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 64.07 E-value: 3.46e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 18 IISLGIRQSFGIFMMPISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESS 97
Cdd:cd17421 13 VLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSAGFLISIFATSVP 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 98 MLYVSLGALIGLGLSatsyviVLGAVAKVVPAEHAAKAFGLTTAAGSFGM---FAVIPGAQYMLNEFDWQSAMQVFGVLC 174
Cdd:cd17421 93 FLYVSMGLLVGLGFA------FLYQAAAVMTAKYFKKRLATAYAIARSGMgltFALAPFTQLLLDEYDWQGALLIFGGIM 166
|
170
....*....|.
gi 2793981667 175 CLMISFALFMR 185
Cdd:cd17421 167 LNLVASGMLLR 177
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-386 |
6.86e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 63.33 E-value: 6.86e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 1 MSIFRFPLLVWLGIGTLIISLGIRQSFGIFMMPISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGA 80
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 81 CAYGLGLLLTSISTESSMLyvsLGALIGLGLSATSYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLN- 159
Cdd:COG0738 81 LLMALGLLLFALAPSYPLL---LLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILl 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 160 --EFDWQSAMQVFGVLCCLMISFALFMRAPKAAsnkqAQAEENQTLKEALSEAFAHKGYWLIHAGFFVCGFHVMFIATHL 237
Cdd:COG0738 158 glSLSWHLPYLILAVLLLLLALLFLRSKLPEIE----EEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 238 PSYLAD-KDLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIGAFVTLPvTESTAAIFGAAIGFC 316
Cdd:COG0738 234 PLYLKDvLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAP-GPWLALIGLALVGLG 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 317 WLGTVPLTSGLVRQIFGaRYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGsyepIWWSTVVLAFAAALI 386
Cdd:COG0738 313 LSLMFPTIFSLALDGLG-KRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFG----LRAAFLVPLVCYLLI 377
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
45-360 |
7.75e-10 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 60.06 E-value: 7.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 45 FSFSIALQNLLFGVFqpFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVsLGALIGLGLSATsYVIVLGAVA 124
Cdd:TIGR00895 56 FLFSAGLIGMAFGAL--FFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLI-LRFLAGLGLGGL-MPNLNALVS 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 125 KVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVLCCLMISFALF----------------MRAPK 188
Cdd:TIGR00895 132 EYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRflpesidflvskrpetVRRIV 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 189 AASNKQAQAEENQTLKEALSEAFAHKGYW-------------LIHAGFFVCGFHVMFIATHLPSYLADKDLPASSAAMAL 255
Cdd:TIGR00895 212 NAIAPQMQAEAQSALPEQKSTQGTKRSVFkalfqgktaritvLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGG 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 256 AYVGIFNIFGSYFWGVMGDKFSKRHVMSALYL--VRTVVIGAFVTLPvteSTAAIFGAAIGFCWLGTVPLTSGLVRQIFG 333
Cdd:TIGR00895 292 ALFNFGGVIGSIIFGWLADRLGPRVTALLLLLgaVFAVLVGSTLFSP---TLLLLLGAIAGFFVNGGQSGLYALMALFYP 368
|
330 340
....*....|....*....|....*..
gi 2793981667 334 ARYLSTLYGLVFFTHQVGSFLGAWVGG 360
Cdd:TIGR00895 369 TAIRATGVGWAIGIGRLGAIIGPILAG 395
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
34-388 |
1.32e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 59.12 E-value: 1.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 34 ISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLyVSLGALIGLGLSA 113
Cdd:cd17474 25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALL-LAGRALQGIGAAG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 114 TSyVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMfAVIPGAQYMLNEFDWQSAMQVFGVLCCLMISFALFMRAPKAASNK 193
Cdd:cd17474 104 LG-PLALTLIGDLFEGGERAKAMGLYEAALGLGI-AVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 194 QAQAeenqTLKEALSEAFAHKGYWLIHAGFFVCGFHVMFIATHLPSYLADK-DLPASSAAMALAYVGIFNIFGSYFWG-V 271
Cdd:cd17474 182 SSSA----TKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLyGISPIIIGLLFAGWSVLLALGSLFVGrL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 272 MGDKFSKRHVM---SALYLVRTVVIGAFVTLPVTESTAAIFGAAIGfcwlGTVPLTSGLVRQIFGARYLSTLYGLVFFTH 348
Cdd:cd17474 258 LKKRFGARRILvigLLLYALSLLLLGFVPSLALLLIAIVLFGLGLG----LNLPLLTTLVTELAPEEERGTASSLYNFVR 333
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 2793981667 349 QVGSFLGAWVGGRIYDYYGSYEPIWWSTVVLAFAAALIHL 388
Cdd:cd17474 334 FLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
47-385 |
1.96e-09 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 58.75 E-value: 1.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 47 FSIALQNLLFGVFqpFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLyVSLGALIGLGLSAT-SYVIVLgaVAK 125
Cdd:cd17365 40 GSAALFGMAIGAL--LAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQL-ALLRFLTGLGLGAAmPNAITL--VSE 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 126 VVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVLCCLmisFALFMRApkaasnkqaqaeenqTLke 205
Cdd:cd17365 115 YAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLI---LLPLLRG---------------TL-- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 206 alseafahkgywLIHAGFFVCGFHVMFIATHLPSYLADKDLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSAL 285
Cdd:cd17365 175 ------------LLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALF 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 286 YLVRTVVIGAFVTLPVTESTAAIFGAAIGFCWLGTVPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDY 365
Cdd:cd17365 243 FALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAA 322
|
330 340
....*....|....*....|
gi 2793981667 366 YGSYEPIWWSTVVLAFAAAL 385
Cdd:cd17365 323 GLGPESVFLALAIPAALGAL 342
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
18-370 |
5.00e-09 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 57.53 E-value: 5.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 18 IISLGIRQSFGIFMMPISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESS 97
Cdd:cd17429 13 ILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSLGWVLSAYATNVH 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 98 MLYVSLGALIGLGlSATSYVIVLGAVAKVVPAEHAAkAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVfgvlcclm 177
Cdd:cd17429 93 YLFISFGVTAGIG-SGMAYLPAVVMVGQYFQKRRAL-AQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAMFI-------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 178 isfalfmrapkaasnkQAQAEENQTLKEALSEAFAHKGY--WLIHAGFFVCGFHVMFIatHLPSYLADKDLPASSAAMAL 255
Cdd:cd17429 163 ----------------QGAVSLNLCVCGALMRLFTNKVFvaFIFWALFAYCSFVIPFI--HLPEIVKLYGLSEQNDKFPL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 256 -AYVGIFNIFGSYFWGVMGDkFSKRHVMSALYLVRTVVIGAFVTLPV--TESTAAIFGAAIGFCwLGTVPLTSGLVRQIF 332
Cdd:cd17429 225 tSIIAIVHIFGKVILGIICD-LPCISVWNVFILANFTLGVCILILPLmhTYTGLAIVCALIGFS-SGYFSLMPVVTEDLV 302
|
330 340 350
....*....|....*....|....*....|....*...
gi 2793981667 333 GARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYE 370
Cdd:cd17429 303 GIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYD 340
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
69-386 |
7.61e-09 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 56.93 E-value: 7.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 69 KWGARRIIIAGACAYGLGLLLTSISTeSSMLYVSLGALIGLGlSATSYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMF 148
Cdd:cd06180 60 RGRARRLIRGGLLLTVLLLAAMALTS-GFAALLALRFLAGAA-SAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIA 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 149 ----AVIPGAQYMLNefdWQSAMQVFGVL--CCLMISFALFMRAPKAasnkqaqaeeNQTLKEALSEAFAHKGYWLIHAG 222
Cdd:cd06180 138 lsglLVPAGLGGGLS---WRAGWLALALLsaVLLLLSFLLLRRGPSA----------PTEASAAESAPGLNRPLWRLALA 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 223 FFVCGFHVMFIATHLPSYLADKDLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIGAFVTLPvT 302
Cdd:cd06180 205 YGLFGFGYIITATFLPLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSP-G 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 303 ESTAAIFGAAIGFCWLGTVPLTSGLVRQIFGARYLSTLyGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVLAFA 382
Cdd:cd06180 284 PAGLVLSAVLFGGTFMAITALVMALARELAPPAAPRAL-ALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVV 362
|
....
gi 2793981667 383 AALI 386
Cdd:cd06180 363 AALL 366
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
18-369 |
9.49e-09 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 56.74 E-value: 9.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 18 IISLGIRQSFGIFMMPISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESS 97
Cdd:cd17424 13 VCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLASTGLILSSFATSLE 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 98 MLYVSLGALIGLGLsATSYVIVLGAVAKVVpAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVLCCLM 177
Cdd:cd17424 93 YLYLTLGVLTGLGF-ALCYSPAIAMVGKYF-HKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 178 ISFALFMRapkaasnkqaqaeenqtlkealseafahkgyWLIHAGFFVCGFHVMFIA-------THLPSYLADKDLPASS 250
Cdd:cd17424 171 CVCGALMR-------------------------------FLLMPDFLVLAVSVLFLAygcsppfVYLVPYALSVGVSHQQ 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 251 AAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIG-AFVTLPVTESTAAI--FGAAIGFCWLGTVPLTSGL 327
Cdd:cd17424 220 AAFLMSILGVIDIIGNITFGWLTDRRCLKKYRYFCYLFAVGMDGlCCLFLPILKTFPLLvpFSFTFGYFDGAYVALIPVV 299
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 2793981667 328 VRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSY 369
Cdd:cd17424 300 TSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTY 341
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
61-385 |
1.51e-08 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 56.04 E-value: 1.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 61 PFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVSLGALIGLGLsATSYVIVLGAVAKVVPAEHAAkAFGLTT 140
Cdd:cd17426 56 PISSILVNKYGSRPIMIAGGCLSGAGLIAASFCNTVEGLYFCVGVVGGLGL-AFNLNPALTMIGKYFYKKRPL-ANGLAM 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 141 AAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVL---CCLMISfalFMR--APKAASNKQaqaeenqtlkealseAFAHKG 215
Cdd:cd17426 134 AGSPVFLSTLAPLNQWFFDIFGWRGSFLILGGLllnCCVAGS---LMRpiGPKPFLDLT---------------LFTHRG 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 216 YWLIHAGFFVCGFHVMFIATHLPSYLADKDLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIGA 295
Cdd:cd17426 196 FLLYLSGNVIMFFGLFAPLVFLSNYAKSKQISNESAAFLLSILAFVDMVARPSMGIVANTKWVRPRIQYFFAASVLYNGV 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 296 ---FVTLPVTESTAAIFGAAIGFC--WLGTVPLTSglVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYE 370
Cdd:cd17426 276 chlLAPLSTSYVGFCIYAIFFGFAfgWLSSVLFET--LMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYK 353
|
330
....*....|....*
gi 2793981667 371 PIWWSTVVLAFAAAL 385
Cdd:cd17426 354 YTYWACGIVLIISSI 368
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
5-190 |
2.07e-08 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 55.66 E-value: 2.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 5 RFPLLVWLGIGTLIISLGIRQSFGIFMMpisEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYG 84
Cdd:COG2223 206 RFWLLSLLYFGTFGSFIGFSSWLPPYLV---DQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMA 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 85 LGLLLTSISTESSMLYVSLGALIGLGLSATSyVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEF-DW 163
Cdd:COG2223 283 LGLLLLALALGSLWLFLVLFLLLGLALGGGN-GAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSY 361
|
170 180
....*....|....*....|....*..
gi 2793981667 164 QSAMQVFGVLCCLMISFALFMRAPKAA 190
Cdd:COG2223 362 TAAFLVFAVLALVALVLTLLLYRRPRR 388
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
49-386 |
2.94e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 55.29 E-value: 2.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 49 IALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVSLgALIGLGLSATSYVIVLGaVAKVVP 128
Cdd:cd17489 37 VGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLR-LIHGIGWGAFTTAAATL-VADIIP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 129 AEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVLCCLMISFALFMRAPKAAsnkqaqAEENQTLKEALS 208
Cdd:cd17489 115 PSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPV------AAEEAEAGTRAF 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 209 EAFAHKGYWLIHAGFFVCGFHVMFIATHLPSYLAdkDLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLV 288
Cdd:cd17489 189 RRLVEKKVLPPALILFLASIAYGAISTFLPLYAA--ERGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 289 RT---VVIGAFVTLPVTESTAAIFGAAIGFCWLGTVPLTSGLVRQIFGARYLSTLYGLVffthQVGSFLGAWVGGRIYDY 365
Cdd:cd17489 267 LAlglLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFF----DLGIGLGGLLLGLVAEL 342
|
330 340
....*....|....*....|.
gi 2793981667 366 YGsYEPIWWSTVVLAFAAALI 386
Cdd:cd17489 343 FG-YRAMFLLAAVVVLLALVL 362
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
58-388 |
8.23e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 53.77 E-value: 8.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 58 VFQPFVGMAADKWGARRIIIAGACAYGL---GLLLTSISTESSMLYVSLGALIGLGLSATSYVIVLGAVAKVVPAEHAAK 134
Cdd:cd06173 49 LFSPFAGVLADRFDRRRLLILADLLRALlaaVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVR 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 135 AFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVLCCLMISFALFMRAPKAASNKQAQAEENQTLKEALSEAFAHK 214
Cdd:cd06173 129 ANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSP 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 215 GYWLIHAGFFVCGFHVMFIATHLPSYLADK-DLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVI 293
Cdd:cd06173 209 LLRLLLLALALFALLGGALTVLLPLLAKEVlGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLAL 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 294 GAFVTLPVTESTAAIFgAAIGFCWLGTVPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIW 373
Cdd:cd06173 289 LVLGLSPSLWLLLAAL-FLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFL 367
|
330
....*....|....*
gi 2793981667 374 WSTVVLAFAAALIHL 388
Cdd:cd06173 368 LAGALLLLAALLLLL 382
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
34-313 |
1.09e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 53.35 E-value: 1.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 34 ISEHFGTGREFF-SFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVSLgALIGLGLS 112
Cdd:cd17473 25 IAQHFVPNSELLvPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASR-ALLGIGVA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 113 ATsYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFG--MFAVIPGAqymLNEFDWQSAMQVFGVLCCLMISFALFMRAPKAA 190
Cdd:cd17473 104 GI-MTLATALIGDYFEGEERAKMLGLQSAAMSLGgvVFLLLGGA---LAEIGWRAPFLVYLLALPVLILVLLFLPEPARK 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 191 SnkqaqaEENQTLKEALSEAFAHKGYWLIHAGFFVCGFHVMFIATHLPSYLADKDL-PASSAAMALAYVGIFNIFGSYFW 269
Cdd:cd17473 180 S------KSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGgSAALIGLALAIASLAGAIGALLF 253
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 2793981667 270 GVMGDKFSKRHVMSALYLvrtVVIGAFVTLPVTESTAAIFGAAI 313
Cdd:cd17473 254 GRLKRRLGKRRLLAIGFA---LMALGFLLLALASGLWVVLLGAI 294
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
49-386 |
2.46e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 52.17 E-value: 2.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 49 IALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVSLgALIGLGLSAtsYVIVLGAVAKVVP 128
Cdd:cd17478 37 VSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV-ALAGIGSAA--FHPEGARLASQAA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 129 AEHAAKAFGLTTAAGSFGmFAVIPGAQYMLNEFDWQSAMQVFGVLcCLMISFALFMRAPKAASNKQAQAEENQTLKEALS 208
Cdd:cd17478 114 GGRRGLAMSIFSVGGNLG-FALGPLIAAALVALFGGLGLLILLII-PGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLK 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 209 EAFahKGYWLIHAGFFVCGFHVMFIATHLPSYLADKDLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLV 288
Cdd:cd17478 192 GVW--RALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 289 RTVVIGAFVTLPVTESTAAIFgaAIGFCWLGTVPLTSGLVRQIFgARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGS 368
Cdd:cd17478 270 AAPFLLLFLLTPGIWSYILLV--LAGFLLFASFPVTVVLAQELL-PGNVGLASGLMMGLSFGLGGIGAPVLGALADAFGL 346
|
330
....*....|....*...
gi 2793981667 369 YEPIWWSTVVLAFAAALI 386
Cdd:cd17478 347 ESVLLILALLPLLGALLA 364
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
8-386 |
2.73e-07 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 52.28 E-value: 2.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 8 LLVWLGIGTLIISlgiRQSFGIFMMPISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGL 87
Cdd:cd17312 6 LGVFLGYAAYYVC---RKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALAN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 88 LLTSISTESSMLYVSLGaLIGLGLSATSYVIVLGAVAKVVPAEHAAKaFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAM 167
Cdd:cd17312 83 IFMGFSTSLWFFAVLWG-LNGLFQSMGWPPCVKLLGNWFSKKERGTV-YGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 168 QVFGVLCCLMISFALFMrapkaasnkqaQAEENQTLkealseafahkgyWLIHAGFFVCGFHVMFIATHLPSYLADKDlp 247
Cdd:cd17312 161 LVPGIVGLVVAIILFFF-----------LRDSPPYV-------------WVLSLAYAFVYIVRYACLDWGPLYLYEVK-- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 248 ASSAAMALAYVGIFN---IFGSYFWGVMGDKF--SKRHVMSALYLV-RTVVIGAFVTLPVTESTAAIFGAAIGFCWLGTV 321
Cdd:cd17312 215 GYSLIDAGWFSSLYEvggIAGTILAGLLSDKLfgGRRAPIAVIYMLlMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPI 294
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2793981667 322 PLTSGLVRQIFGARY-LSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGsyepiwWSTVVLAFAAALI 386
Cdd:cd17312 295 NLIGGAAAQDIGRKEaAGTATGFVGLFGYLGASLAGLPLGYIIDHYG------WSTVFYFLISAAL 354
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
61-386 |
3.05e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 51.79 E-value: 3.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 61 PFVGMAADKWGARRIIIAGACAYGLGLLLTSISTeSSMLYVSLGALIGLGLsATSYVIVLGAVAKVVPAEHAAKAFGLTT 140
Cdd:cd17477 49 PLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD-SPWVWFLLRFVMGIGL-AGLFVVSESWLNALATNENRGRVLGLYS 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 141 AAGSFGMFAvipgAQYMLNEFDWQSAMQVFGVLCCLMISFALFMRAPKAAsnKQAQAEENQTLKEALSEAfahkgyWLIH 220
Cdd:cd17477 127 TVLGLGFAL----GPLLLALVGTAGALPFLIAAVLLLLALVPLLLTRRAA--PEIEEAESISLRRLLRIA------PLAL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 221 AGFFVCGFHVMFIATHLPSYLADKDLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIGAFVTLP 300
Cdd:cd17477 195 LGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVP 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 301 VTESTAAIFGAAIGFCWLGTVPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVLA 380
Cdd:cd17477 275 GLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVAL 354
|
....*.
gi 2793981667 381 FAAALI 386
Cdd:cd17477 355 LFLLFL 360
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
62-319 |
5.09e-07 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 51.15 E-value: 5.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 62 FVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVsLGALIGLGLsATSYVIVLGAVAKVVPAEHAAKAFGLTTA 141
Cdd:cd17371 53 LGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLI-LRALAGLGF-GGEWAAGAALMAEYVPARHRGKALGYVQS 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 142 AGSFGMFAVIPGA----QYMLNEFDWQsAMQVFGVLCCLMIsfaLFMR--APKAASNKQAQAEENQTLKEALSEAFAHKG 215
Cdd:cd17371 131 GWAVGWLLATLLAallfPLLPPEIAWR-VLFLLGALPALLV---LFIRrfVKEPPQWQAARAARRHFADRPSLRELFSPP 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 216 YW--LIHAGFFVCGFHVMF--IATHLPSYL-ADKDLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRT 290
Cdd:cd17371 207 LLrtTLLASLLATGALGGYygITTWLPSYLtGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSA 286
|
250 260
....*....|....*....|....*....
gi 2793981667 291 VVIGAFVTLPVTESTAAIFGAAIGFCWLG 319
Cdd:cd17371 287 ISILLYFFLPLSPTLILILGFPLGFFASG 315
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
23-367 |
6.74e-07 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 50.84 E-value: 6.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 23 IRQSFGIFMMPISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTeSSMLYVS 102
Cdd:TIGR00881 10 VRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST-SLWVMAA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 103 LGALIGLgLSATSYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEF-DWQSAMQVFGvLCCLMISFA 181
Cdd:TIGR00881 89 LWALNGI-FQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELySWHWVFIVPG-IIAIIVSLI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 182 LF-----------------MRAPKAASNKQAQAEENQTLKEALSEAFAHKGYWLIHAGFFVCGFHVMFIATHLPSYLADK 244
Cdd:TIGR00881 167 CFlllrdspqscglppaeeMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQE 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 245 ---DLPASSAAMALAYVGifNIFGSYFWGVMGDKF--SKRHVMSALY--LVRTVVIGAFVTLPVTESTAAIFGAAIGFCW 317
Cdd:TIGR00881 247 kgfSKEKASWAFTLYELG--GLVGTLLAGWLSDKLfnGRRGPLAVFFmaLIIVSLLVYWLNPAANPLMDLICLFALGFLV 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 2793981667 318 LGTVPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYG 367
Cdd:TIGR00881 325 YGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
2-187 |
1.61e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 49.87 E-value: 1.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 2 SIFRFPLLVWLGIGTLIISLGIRQSFGIFMMPI-SEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGA 80
Cdd:COG2271 174 GLLLALLRFWLLALAYFLVYFALYGFLTWLPTYlVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAI 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 81 CAYGLGLLLTSISTESSMLYVSLGALIGLGLSATSYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNE 160
Cdd:COG2271 254 GLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDA 333
|
170 180
....*....|....*....|....*..
gi 2793981667 161 FDWQSAMQVFGVLCCLMISFALFMRAP 187
Cdd:COG2271 334 TGYQAAFLLLAALALLAALLALLLLRE 360
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
62-386 |
5.33e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 47.98 E-value: 5.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 62 FVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVsLGALIGLGLSAtSYVIVLGAVAKVVPAEHAAKAFGLTTA 141
Cdd:cd17316 55 LFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLV-LRFLQGIGIGG-EYPGASTYVAEFAPSKRRGFALGLLQS 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 142 AGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVLCCLMISFALFMRapkaasnkqaqaeenqtlkealseafahKGYWLIHA 221
Cdd:cd17316 133 GWALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLALLLR----------------------------RRTLLLIL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 222 GFFVCGFHVMFIATHLPSYL-ADKDLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTV-VIGAFVTL 299
Cdd:cd17316 185 LWFFISFGYYGLTTFLPTYLqTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGIlALPLFYLL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 300 PVTESTAAIFGAAIGFCWLGTVPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVL 379
Cdd:cd17316 265 SGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALL 344
|
....*..
gi 2793981667 380 AFAAALI 386
Cdd:cd17316 345 AIVALIV 351
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
54-367 |
7.18e-06 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 47.62 E-value: 7.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 54 LLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVsLGALIGLGLSatSYVIVLGAV-AKVVPAEHA 132
Cdd:cd17328 45 ISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLL-FRALVGIGEA--SYSPIAPTIiADLFPKEKR 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 133 AKAFGLTTAAGSFG-MFAVIPGAQYMLNEFDWQSA---MQVFGVLCCLMISFALFMRAPKAASNKQAQAEENQTLKEALS 208
Cdd:cd17328 122 TRALGVFYFAIPLGsGLGYVVGGLVAQATGGWRWAfrvTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADLK 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 209 EAFAHKGYWLIHAGF----FVCGFHVMFIATHLPSYLADKDLPASSAAMAL-AYVGIFNIFGSYFWGVMGDKFSKRHV-- 281
Cdd:cd17328 202 ALAKNPSFILSTLGFtavsFVTGALAFWAPTFFLRAFGVGDLSSADVGLIFgAITCIAGVLGVLLGGILADRLRRKTPra 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 282 -----MSALYLVRTVVIGAFVTLPVTESTAAIFGAAIGFCWLGTVPLTSGLVRQIFGARYLSTLYGL-VFFTHQVGSFLG 355
Cdd:cd17328 282 dplvcAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIqILLSHLLGDAGS 361
|
330
....*....|..
gi 2793981667 356 AWVGGRIYDYYG 367
Cdd:cd17328 362 PYLIGLISDLLR 373
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
14-385 |
8.21e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 47.64 E-value: 8.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 14 IGTLIISLGIRQSFGIFMMPISEHFGTGREFFSF----SIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLL 89
Cdd:cd17391 3 LGNFFTGIGFSLIAPFLPLYIEQLGVTSGGLVELwsglAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 90 TSISTEssmLYVSLGALIGLGLSATSYVIVLGAVAKVVPAEHAAKAFG-LTTAAGSFGMFAVIPGAqYMLNEFDWQSAMQ 168
Cdd:cd17391 83 MAFVTN---VWQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGtLSTGVVAGTLIGPLLGG-FLADLFGIRNVFF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 169 VFGVLccLMISFALFMRAPKAASnKQAQAEENQTLKEALSEAFAHKGYWLIHAGFFVCGFHVMFIATHLPSYLADKDLPA 248
Cdd:cd17391 159 ITGGL--LFLAFLLTLFFVKEDF-KPVEKKKMVSTKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQLMGDA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 249 SSAA----MALAYVGIFNIFGSYFWGVMGDKFSKRHVM--SALYLVRTVVIGAFVTlpvTESTAAIFGAAIGFCWLGTVP 322
Cdd:cd17391 236 SNLAfisgLVFSATGVSSLLSAPRLGKLGDRIGHHRILlgALLASALLYIPQAFVQ---TPWQLGILRFLLGLATGGLLP 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2793981667 323 LTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGsYEPIWWSTVVLAFAAAL 385
Cdd:cd17391 313 AINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFG-YRAVFVVTALLVLLNAI 374
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
217-386 |
1.03e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 47.28 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 217 WLIHAGFFVCGFHVMFIATHLPSYLADKDLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIGAF 296
Cdd:COG2814 13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 297 VTLPvTESTAAIFGAAIGFCWLGTVPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGsYEPIWWST 376
Cdd:COG2814 93 ALAP-SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-WRWVFLVN 170
|
170
....*....|
gi 2793981667 377 VVLAFAAALI 386
Cdd:COG2814 171 AVLALLALLL 180
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
44-362 |
3.48e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 45.69 E-value: 3.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 44 FFSFSIALQNLLFGVF-------QPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSM-LYVSLGALIGLGLSAT- 114
Cdd:cd17318 50 EFDWSEKTQGIILSSFfygyiltQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYgALIVLRILQGLAQGVTf 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 115 --SYVIVlgavAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVLCCLMISFALFMRAPkaasn 192
Cdd:cd17318 130 paMHALW----AKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLVLP----- 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 193 kqaqaeenqtlkealseafahkgYWLIHAGFFVCGFHVMFIATHLPSYLAD---KDLPASSAAMALAYVGIfnIFGSYFW 269
Cdd:cd17318 201 -----------------------VWAIVVAHFGHNWGFYTLLTELPTYMSDvlhFNIKSNGFLSSLPYLAM--WICSIVG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 270 GVMGDKFSKRHVMS----------------ALYLVRTVVIGAFVTLPVTESTAAIfgAAIGFCWLGtvPLTSGLVrqiFG 333
Cdd:cd17318 256 GYLADWLRSRGILStttvrklftsigflgpGVFLIALGYLGSNATLAVVFLTLSV--GLSGACYSG--FLVNHLD---LA 328
|
330 340
....*....|....*....|....*....
gi 2793981667 334 ARYLSTLYGLVFFTHQVGSFLGAWVGGRI 362
Cdd:cd17318 329 PNYAGTLMGITNTAATIAGIISPLIVGAI 357
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
222-399 |
3.49e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.49 E-value: 3.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 222 GFFVCGFHVMFIATHLPSYLA-DKDLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVrTVVIGAFVTLP 300
Cdd:pfam07690 4 AAFLAALGRSLLGPALPLLLAeDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLL-FALGLLLLLFA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 301 VTESTAAIFGAAIGFCWLGTVPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVLA 380
Cdd:pfam07690 83 SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSL 162
|
170
....*....|....*....
gi 2793981667 381 FAAALIHLPINDKPIERLK 399
Cdd:pfam07690 163 LAAVLLLLPRPPPESKRPK 181
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
47-113 |
3.69e-05 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 45.32 E-value: 3.69e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 47 FSIALQNLLFGVFQPFV-GMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVSL--GALIGLGLSA 113
Cdd:cd17388 246 LSLAVFGLLHALFQAFVtGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILilLALGGIAGPA 315
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
11-385 |
4.14e-05 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 45.19 E-value: 4.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 11 WLGIGTLIISLGIRQSF----GIFMMPISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLG 86
Cdd:cd17427 2 WAVVFGAFISIGFSYAFpkaiTVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 87 LLLTSISTESSMLYVSLGALIGLGLS---ATSYVIVLGAVAKVVPAehaakAFGLTTAAGSFGMFAVIPGAQYMLNEFDW 163
Cdd:cd17427 82 MISASFCNSVMQLYLCIGVIGGLGLAfnlQPALTIIGKYFYKKRPI-----ANGLAMAGSPVFLSTLAPLNQFLFNQFGW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 164 QSAMQVFGVL---CCLMISfalfmrapkaasnkqaqaeenqtLKEALSEAFAHKGYWLIHAGFFVCGFHVMFIATHLPSY 240
Cdd:cd17427 157 RGSFLILGGLllnCCVAGS-----------------------LMRPLGPLFKHRGFLIYLSGNVIMFLGFFAPIVFLAPY 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 241 LADKDLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIG-AFVTLPVTESTAA--IFGAAIGFCW 317
Cdd:cd17427 214 AKHMGIDEYSAAFLLSILAFVDMFARPSMGLVANSKWIRPRIQYFFSFAVMYNGvCHLLCPLAEDYTGlvIYAVFFGFAF 293
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2793981667 318 LGTVPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVLAFAAAL 385
Cdd:cd17427 294 GMVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIVASI 361
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
64-388 |
4.25e-05 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 45.24 E-value: 4.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 64 GMAADKWGARRIIIAGACAYGLGLLLTSISTESSM--LYVS---LGALIGLGLSATSYVIvlgavAKVVPAEHAAKAFGL 138
Cdd:cd17380 55 GYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLplLILSrilLGLGEGVHFPSMTSLF-----SRWVPVSERSRAVSI 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 139 TTAAGSFG-MFAVIPGAqYMLNEFDWQSAMQVFGVLCclmISFALFMRapkaasnkqaqaeenqtlkealseaFAHKGYW 217
Cdd:cd17380 130 VTAGSYLGtLLGGLIGP-LLLEYYGWPSVFYFFGLLG---LLWALVWL-------------------------IYLPPVW 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 218 LIHAGFFVCGFHVMFIATHLPSYLADKDLPASSAAMALAYVGIFNIFGSYFWGVMGDKF--------SKRHVMSALYLVR 289
Cdd:cd17380 181 AIIVAHFCMNWGFYILLSWLPTYFHEVLVPLAKGWVFNVVPWLVMFPSSNVAGWLADHLisrgwtvtSVRKLMQSIGFLG 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 290 TVVIGAFVTLPVTESTAAIF-GAAIGFCWLGTVPLTSGLvrQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGS 368
Cdd:cd17380 261 PALFLLLLSHTDSFSLALLCmSVALGLSAFSSSGVLVNH--QDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEATGS 338
|
330 340
....*....|....*....|
gi 2793981667 369 YEPIWWSTVVLAFAAALIHL 388
Cdd:cd17380 339 WSLVFVLAAVVNLVGAVVFL 358
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
9-385 |
5.16e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.91 E-value: 5.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 9 LVWLGIGTLIISLGIrqSFGIFMMPI--SEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLG 86
Cdd:cd17329 1 LWVLLIGSFLNRLGF--FMVWPFMAIylHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 87 LLLTSIStESSMLYVSLGALIGLGlSATSYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMF--AVIPGAQYMLNeFDWq 164
Cdd:cd17329 79 FALLGFA-HSPWLFAIALVLTGFG-GGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAigPLLGGLLLLYS-FRL- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 165 samqVFGVLCCLMISFALFMRAPKAASNKQAQAEENQTLKEALSEAFAHKGYWLIHAGFFVCGFHVMFIATHLPSYLAD- 243
Cdd:cd17329 155 ----LFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEi 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 244 KDLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVvigAFVTLPVTESTAAIFGAAIgFCWLGTV-- 321
Cdd:cd17329 231 LGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAI---GFAVLAFANTLAVLILAMI-VLTLGEMlv 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2793981667 322 -PLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVLAFAAAL 385
Cdd:cd17329 307 fPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAAL 371
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
5-190 |
8.46e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 44.03 E-value: 8.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 5 RFPLLVWLGIGTLIISLGIrQSFGIFMMPISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYG 84
Cdd:COG0477 12 RRRALLALALGTFLEGLDF-TIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 85 LGLLLTSISTESSMLYVsLGALIGLGLSATsYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQ 164
Cdd:COG0477 91 LASLLCGLAPSPELLIA-ARALQGIGAGGL-MPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWR 168
|
170 180
....*....|....*....|....*.
gi 2793981667 165 SAMQVFGVLCCLMISFALFMRAPKAA 190
Cdd:COG0477 169 WIFLINAPLGLLALVLRLRLPESRGL 194
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
34-385 |
1.69e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 43.33 E-value: 1.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 34 ISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVsLGALIGLGLSA 113
Cdd:cd17320 25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLI-ARFLQGLGAAA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 114 TSyVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMfAVIPGA-QYMLNEFDWQSAMQVFGVLcCLMISFALFMRAPKAASN 192
Cdd:cd17320 104 GS-VVARAIVRDLYSGAELAKIFSLLMMILAIAP-ALAPLLgGLLLLFFGWRAIFVFLALL-GLLLLLLVLLFLPETLPE 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 193 KQAQAEENQTLKeALSEAFAHKGYWLiHAGFFVCGFHVMFIATHLPSYLADKDLPASSAAMALAYV--GIFNIFGSYFWG 270
Cdd:cd17320 181 EKRKPLLSSLLR-AYKRVLKNRRFLG-YALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFAlnAIALILGSLLNG 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 271 VMGDKFSKRHVM------SALYLVRTVVIGAFVTLPVTESTAAIFGAAIGFCWLGTVPLTSGLVRQIFGARYLSTLYGLV 344
Cdd:cd17320 259 RLVRRFGPRRLLrlglllLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLGFL 338
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 2793981667 345 FFthqVGSFLGAWVGGRIYDyyGSYEPIWWSTVVLAFAAAL 385
Cdd:cd17320 339 QF---LIGALAGALVGLLPN--GTALPMGLLILVLGLLALL 374
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
50-184 |
1.93e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 43.30 E-value: 1.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 50 ALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVSLgALIGLGLSATSyVIVLGAVAKVVPA 129
Cdd:cd17370 241 ALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGF-ILWGLYMGAQE-SIERAAVADLVPA 318
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 2793981667 130 EHAAKAFGLTTAAGSFGMFA--VIPGAQYmlnefDWQSAMQVFGVLCCLMISFALFM 184
Cdd:cd17370 319 ELRGTAYGLFNTVVGIGWLLasLIAGYLW-----DLISPSAAFLFSAVLALIALLLL 370
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
222-399 |
2.15e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 43.18 E-value: 2.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 222 GFFVCGFHVMFIATHLPSYLADKDLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLVRTVVIGAFvTLPV 301
Cdd:cd06174 4 GFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF-AFAP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 302 TESTAAIFGAAIGFCWLGTVPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDY--YGSYEPIWWSTVVL 379
Cdd:cd06174 83 SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALA 162
|
170 180
....*....|....*....|
gi 2793981667 380 AFAAALIHLPINDKPIERLK 399
Cdd:cd06174 163 LLAAILLLLVVPDPPESARA 182
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
44-385 |
2.26e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.95 E-value: 2.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 44 FFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVslgALIGLGLSATSYVIVLGAV 123
Cdd:cd17330 35 YVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFL---ARFLDGLTGGNVSVAQAYI 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 124 AKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVLCCLMISFALFMRAPkaasnkqaqaeenqtl 203
Cdd:cd17330 112 ADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPP---------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 204 kealseafahkgYWLIHAGFFVCGFHVMFIATHLPSYLADK-DLPASSAAMALAYVGIFNIFGSYF-WGVMGDKFSKRHV 281
Cdd:cd17330 176 ------------LRRLLLVYFLIALAFAGLESVFSLFLKDRfGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 282 MSALYLVrtVVIGAFVTLPVTESTAAIFGAAI-GFCWLGTVPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGG 360
Cdd:cd17330 244 LRLGLLL--AIIGLLLLPFASSVPLLVLAAAIlAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAG 321
|
330 340
....*....|....*....|....*
gi 2793981667 361 RIYDYYGSYEPIWWSTVVLAFAAAL 385
Cdd:cd17330 322 PLYSFLGPGVPFLLAAGLLLIALFL 346
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
217-386 |
2.30e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.92 E-value: 2.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 217 WLIHAGFFVCG-FHVMFIATHLpsyladKDLPASSAAMALAYVgIFNIF---GSYFWGVMGDKFSKRHVMSALYLVrtVV 292
Cdd:cd17370 205 YLLAVALFALGnFSFAFLILRA------QELGLSAALIPLLYA-LFNLVyalAAYPAGRLSDRIGRKKLLILGYLS--LA 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 293 IGAFVTLPVTESTAAIFGAAIGFCWLGTV-PLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEP 371
Cdd:cd17370 276 LAYLGFALGSSLWLLLLGFILWGLYMGAQeSIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAA 355
|
170
....*....|....*
gi 2793981667 372 IWWSTVVLAFAAALI 386
Cdd:cd17370 356 FLFSAVLALIALLLL 370
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
1-184 |
3.88e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 42.15 E-value: 3.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 1 MSIFRFPLLVWLGIGTLIISLGIrQSFGIFMMPISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGA 80
Cdd:cd17352 177 LRLLKDPTFVLLALGVSFAMLGF-FVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIF 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 81 CAYGLGLLLTSIST-ESSMLYVSLGALIGLGLSATSYVIVLgAVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLN 159
Cdd:cd17352 256 TLLILGLSLLAFPLaTTYVGLIVFSVLFGFCSGSYSSLTPV-ILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRD 334
|
170 180
....*....|....*....|....*
gi 2793981667 160 EFDWQSAMQVFGVLCCLMISFALFM 184
Cdd:cd17352 335 YTGDYDAAFYFCGACLLLSGVLLFL 359
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
2-147 |
5.10e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.20 E-value: 5.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 2 SIFRFPLLVWLGIGTLIISLGIRQSFGIFMMPISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGAC 81
Cdd:COG2211 223 ALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLL 302
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2793981667 82 AYGLGLLLTS-ISTESSMLYVSLGALIGLGLSATsYVIVLGAVAKVVPAEH-------AAKAFGLTTAAGSFGM 147
Cdd:COG2211 303 LAALGLLLLFfLGPGNLWLLLVLAALAGIGLGAI-LVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQ 375
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
61-382 |
8.92e-04 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 41.25 E-value: 8.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 61 PFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVSLGALIGLGLSAT--SYVIVLGAVAKvvpaEHAAKAFGL 138
Cdd:cd17430 56 PLCSILVNRFGCRPVMLVGGLLASLGMILASFCTSIIQLYLTAGVITGLGLALNfqPSLIMLGRYFD----KRRPLANGL 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 139 TTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVL---CClmiSFALFMRAPKAAsnkqaqaeenqtlkealseAFAHKG 215
Cdd:cd17430 132 AAAGSPVFLSALSPLGQILLEEYGWRGGFLILGGLllnCC---TCGAVMRPLDFS-------------------VFRDRG 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 216 Y--WLIHAGFFVCGFHVMFIAthLPSYLADKDLPASSAAMALAYVGIFNIFGSYFWGVM-GDKFSKRHVMsalYLVRTVV 292
Cdd:cd17430 190 FviYTIAKFIMVLGLFVPPIF--VVNYAKDIGVPDTEAAFLLSILGFIDIFARPACGVVaGLKWVRPRVV---YLFSFAM 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 293 IGAFVTlPVTESTAAIFGAAIGFCWL-----GTV-PLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYY 366
Cdd:cd17430 265 LFNGLT-DLCSATAADYGGLVVFCVFfgisyGMVgALQFEVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDAT 343
|
330 340
....*....|....*....|....
gi 2793981667 367 GSYEPIWW--------STVVLAFA 382
Cdd:cd17430 344 KNYELIFYlagsevvlSALFLALG 367
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
1-147 |
1.06e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 41.02 E-value: 1.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 1 MSIFRFPLLVWLGIGTLIISLGIRQSFGIFMMPISEHFGTGREFFSFSIALQNLLFGV----FQPFVGMAADKWGARRII 76
Cdd:cd17504 171 LRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALvmliAGPLAGRLIARVGPRRVL 250
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2793981667 77 IAGACAYGLGLLLTSISTESSMLYVSLGALIGLGLSATsYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGM 147
Cdd:cd17504 251 LIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLA-FASLPNIVVESVPPDRTGIATGMNTVLRTIGS 320
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
22-185 |
1.26e-03 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 40.50 E-value: 1.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 22 GIRQSFGIFMMPISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYV 101
Cdd:cd17422 17 GVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISLGMITASFASSIVEMYL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 102 SLGALIGLGLSATsyviVLGAVAKVvpAEHAAKAFGLTTAAGS----FGMFAVIPGAQYMLNEFDWQSAMQVFGVLCCLM 177
Cdd:cd17422 97 TIGIISGLGYCFT----FLPTVTIL--SQYFKKRRSLVTAIAStgecFAVFAFAPAFTALKESIGWRYCLLVVGALQLNI 170
|
....*...
gi 2793981667 178 ISFALFMR 185
Cdd:cd17422 171 VVCGALLR 178
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
62-386 |
2.16e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 39.93 E-value: 2.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 62 FVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVSLGALIGLGLsaTSYVIVLGAVAKVVPAEHAAKAFGLTTA 141
Cdd:cd17341 53 PYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSSYWGLLVLGFLLGFAG--ANFASGQPWASFWFPKEKIGGAAGGIAG 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 142 AGSFG-------MFAVIPGAQYMLNEFDWQSAMQVFGVLCCLM-ISFALFMRAPKAASNKQAQaeenqtLKEALSEAFAH 213
Cdd:cd17341 131 AGNMGvavsqllAPLIAGAIVFDGGFVGWRNAFFVPGILLAIAaVLVLLFGDDLPTGKASALE------FLKVQLAVLKN 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 214 KGYWLIHAGFFVCGFHVMFIATHLPSYLadKDLPASSAAMALAYVGIF---NIFGSYFWGVMGDKFSKRHVMSALYLVRT 290
Cdd:cd17341 205 YRTWILSLLYGVTFGSFVGFSNVLPTYF--KTRFGLPLVTAGILAALFplaGALARPAGGWLSDRFGGRRRLWWLFIVMT 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 291 VVIGAFVTLPVTESTAAIFGAAIGFCWLGTVPLTSGLVRQIFGARYLSTL---YGLVFFTHQVGSFLGAWVGGRIYDYYG 367
Cdd:cd17341 283 IGAALLSLSLPTSGTNLVLFLALFVALGLGAGAGNGSVFRMVPFIFRRELgavTGLVGAIGGLGGFFLPLLFGSSALMTG 362
|
330
....*....|....*....
gi 2793981667 368 SYEPIWWSTVVLAFAAALI 386
Cdd:cd17341 363 SGVGAFSLFGVLAVACTLL 381
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
221-397 |
2.26e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 39.87 E-value: 2.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 221 AGFFVCGFHVMFIATHLPSYLADKDLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVM---SALYLVRTVVIGAFV 297
Cdd:cd17325 3 LALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLllgLLLLAVSTLLFAFAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 298 TLPVTESTAAIFGAAIGFCWlgtvPLTSGLVRQIFGARYLSTLYGLVFFTHQVGSFLGAWVGGRIYDYYGSYEPIWWSTV 377
Cdd:cd17325 83 SYWQLLLARFLQGLASAAVW----PAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAA 158
|
170 180
....*....|....*....|
gi 2793981667 378 VLAFAAALIHLPINDKPIER 397
Cdd:cd17325 159 LALLALVLALLLLPEPRPPP 178
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
54-147 |
2.66e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.46 E-value: 2.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 54 LLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLYVSLGALIGLGL-SATSYVIVLGAVAKVVPAEHA 132
Cdd:cd17321 215 LAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLgLGLFATPLTNAALSSVPKEKA 294
|
90
....*....|....*
gi 2793981667 133 AKAFGLTTAAGSFGM 147
Cdd:cd17321 295 GAASGILNTARQLGG 309
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
53-313 |
2.73e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.46 E-value: 2.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 53 NLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTESSMLyvsLGALIGLGLSATSYVIVLGA-VAKVVPAEH 131
Cdd:cd17321 41 LLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL---IAARALQGIGAAAIMPASLAlIAATFPGER 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 132 AAKAFGL--TTAAGSFGMFAVIPGAqyMLNEFDWQSAMQVFGVLCCLMIsfalfmrapkaasnkqaqaeenqtlkealse 209
Cdd:cd17321 118 RGRALGLwgAVVGIGAALGPLLGGL--LLELFGWRWIFLINVPIGLVAL------------------------------- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 210 aFAHKGYWLIHAGFFVCGFHVMFIATHLPSYLAD-KDLPASSAAMALAYVGIFNIFGSYFWGVMGDKFSKRHVMSALYLV 288
Cdd:cd17321 165 -LLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGvLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLL 243
|
250 260
....*....|....*....|....*
gi 2793981667 289 RTVVIGAFVTLPVTESTAAIFGAAI 313
Cdd:cd17321 244 TAVGLLLLALLGADSSVWLLLPGLV 268
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
2-183 |
5.29e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 38.56 E-value: 5.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 2 SIFRFPLLVWLGIGTLIISLGIRQSFGIFMMPISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGAC 81
Cdd:cd06174 198 RVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 82 AYGLGLLLTSISTESSMLYVSLGALIGLGLSATsYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEF 161
Cdd:cd06174 278 LLMALGLALLLLAPSLLLLLLLLLLLGFGLGGL-LPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAT 356
|
170 180
....*....|....*....|..
gi 2793981667 162 DWQSAMQVFGVLCCLMISFALF 183
Cdd:cd06174 357 FGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
10-149 |
6.39e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.55 E-value: 6.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 10 VWLGIGTLIISLGIRQSFGIFMMPISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGL-- 87
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAAlg 281
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2793981667 88 LLTSISTESSMLYVSLGALIGLGLSATsYVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMFA 149
Cdd:pfam07690 282 LLLLSLTLSSLWLLLALLLLGFGFGLV-FPALNALVSDLAPKEERGTASGLYNTAGSLGGAL 342
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
16-176 |
7.70e-03 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 38.21 E-value: 7.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 16 TLIISLGIRQSFGIFMMPISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSISTE 95
Cdd:cd17425 11 VQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGVGMVASSFSHS 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 96 SSMLYVSLGALIGLGL--SATSYVIVLGAVAkvvpAEHAAKAFGLTTAAGSFGMFAVIPGAQYMLNEFDWQSAMQVFGVL 173
Cdd:cd17425 91 IVQLYFTAGFITGLGFcfSFQSSVTVLGFYF----VRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSFLVFGGV 166
|
....*.
gi 2793981667 174 ---CCL 176
Cdd:cd17425 167 llnCCV 172
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
33-117 |
9.25e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 37.99 E-value: 9.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 33 PISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTSIsTESSMLYVSLGALIGLGLS 112
Cdd:cd17313 271 AASSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMAL-VHNVTVALVLFALGGIGWA 349
|
....*
gi 2793981667 113 ATSYV 117
Cdd:cd17313 350 TININ 354
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
28-380 |
9.40e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 38.07 E-value: 9.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 28 GIFMMPISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGLGLLLTsISTESSMLYVSLGALI 107
Cdd:cd17333 16 GILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALI-FATPSIYLFVVLMFLA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 108 GLGLSATsyVIVLGAVAKVVPAEHAAKAFGLTTAAGSFGMFAVIPGAQYML-NEFDWQSAMQVFGVLCCLMISFALFMRA 186
Cdd:cd17333 95 GLGAGIL--DTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLtSELSWSWAYLIIGLIYLLLAILILLTLF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 187 PKAASNKQAQAEENQtLKEALSEAFAHKGYWLIHAGFFVCGFHVMFIATHLPSYLADKDLPasSAAMALAYVGIFniFGS 266
Cdd:cd17333 173 PELPSARNPQQSVGA-FSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHV--SDGLAGYLLSGF--WVG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 267 YFWGVMGDKFSKRHVMSALYLVRTVVIG--AFVTLPVTESTAAIF--GAAIGFCWLGTVPLTSGLVRQIFGARYLSTLYG 342
Cdd:cd17333 248 ITIGRLLGGPISRRIKPHTLLVLSGSGAllGLLILLLAPTLVVGLvaTALLGLFMAALFPTILSLGISNLPYAKGKGTSV 327
|
330 340 350
....*....|....*....|....*....|....*...
gi 2793981667 343 LVFFThQVGSFLGAWVGGRIYDYYGSYEPIWWSTVVLA 380
Cdd:cd17333 328 LLAAG-SIGGAIIPFIMGFIAEAVGIQTAMLLITILYA 364
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|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
7-111 |
9.44e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 37.89 E-value: 9.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2793981667 7 PLLVWLGIGTLIISLGIRQSFGIFMMP-ISEHFGTGREFFSFSIALQNLLFGVFQPFVGMAADKWGARRIIIAGACAYGL 85
Cdd:cd17369 227 WRALLLAIGLRLAENVLFYLFTTFALSyATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAAL 306
|
90 100
....*....|....*....|....*...
gi 2793981667 86 GL--LLTSISTESSMLYVsLGALIGLGL 111
Cdd:cd17369 307 FAfpFFWLLDTGSTWLIV-LAAVVVLGV 333
|
|
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