|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
5-471 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 712.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 5 LRKTKIVTTLGPSTDKGNVLEEIIKAGANIVRMNFSHGTSDDHIQRAEKVRTIAKRHGTQIAILGDLQGPKIRVSTFKDG 84
Cdd:PRK05826 3 LRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKEG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 85 KIQLAVGDLFTLDSSLGlGEGNQEAVGLDYKELPNDVSAGDILLLDDGRVQLKVTKVEGCRVHTEVIIGGPLSNNKGINK 164
Cdd:PRK05826 83 KITLKTGDKFTLDTDQK-EEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGINI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 165 KGGGLSAEALTEKDKRDIVTAAQIKVDYLAVSFPRNGEDMHYARQLAREAGLE-AHLVAKVERAETVatvENMDDIIMAS 243
Cdd:PRK05826 162 PGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPhAKIIAKIERAEAV---DNIDEIIEAS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 244 DVVMVARGDLGVEIGDPELVGVQKQLIRRARALNRTVITATQMMESMISAPMPTRAEVMDVANAVLDGTDAVMLSGETAA 323
Cdd:PRK05826 239 DGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAA 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 324 GDYPVETVKSMAEVCIGAEKMAgINNQSNYRIDRTFVTAEETVSMATIYSANHMEGIKGVVTLTESGRTALMMSRLSADM 403
Cdd:PRK05826 319 GKYPVEAVEAMARICKGAEKEF-SINLSKHRLDRQFDRIDEAIAMSAMYAANHLKGVKAIVALTESGRTARLISRFRPGA 397
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2794280068 404 PIYALSRNEGTLNRCTLYRGVTPIYFETEAeDSFDIALSTLTCLKEKGHLKFGDLVIVTQGDIMDVAG 471
Cdd:PRK05826 398 PIFAVTRDEKTQRRLALYRGVYPVLFDSAA-DTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAG 464
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
5-481 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 705.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 5 LRKTKIVTTLGPSTDKGNVLEEIIKAGANIVRMNFSHGTSDDHIQRAEKVRTIAKRHGTQIAILGDLQGPKIRVSTFKDG 84
Cdd:COG0469 2 MRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 85 KIQLAVGDLFTLDSslGLGEGNQEAVGLDYKELPNDVSAGDILLLDDGRVQLKVTKVEGCRVHTEVIIGGPLSNNKGINK 164
Cdd:COG0469 82 PVELKKGDTFTLTT--DDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 165 KGGGLSAEALTEKDKRDIVTAAQIKVDYLAVSFPRNGEDMHYARQLAREAGLEAHLVAKVERAETVatvENMDDIIMASD 244
Cdd:COG0469 160 PGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAV---ENLDEIIEASD 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 245 VVMVARGDLGVEIGDPELVGVQKQLIRRARALNRTVITATQMMESMISAPMPTRAEVMDVANAVLDGTDAVMLSGETAAG 324
Cdd:COG0469 237 GIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVG 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 325 DYPVETVKSMAEVCIGAEKMAGINNQSNYRIDRTFVTAEETVSMATIYSANHMeGIKGVVTLTESGRTALMMSRLSADMP 404
Cdd:COG0469 317 KYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDL-GAKAIVAFTESGSTARRISRYRPKVP 395
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2794280068 405 IYALSRNEGTLNRCTLYRGVTPIYFE--TEAEDSFDIALSTltcLKEKGHLKFGDLVIVTQGDIMDVAGSTNCMRILPV 481
Cdd:COG0469 396 ILALTPNERTARRLALVWGVYPVLVDdvESTDEMIEEAVEA---LLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
5-481 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 587.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 5 LRKTKIVTTLGPSTDKGNVLEEIIKAGANIVRMNFSHGTSDDHIQRAEKVRTIAKRHGTQIAILGDLQGPKIRVSTFKDG 84
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 85 -KIQLAVGDLFTLDSSLGLGEGNQEAVGLDYKELPNDVSAGDILLLDDGRVQLKVTKVEGCR-VHTEVIIGGPLSNNKGI 162
Cdd:cd00288 81 kDISLKAGDKFLVTTDPAAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGGVLGSRKGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 163 NKKGGGLSAEALTEKDKRDIVTAAQIKVDYLAVSFPRNGEDMHYARQLAREAGLEAHLVAKVERAETVatvENMDDIIMA 242
Cdd:cd00288 161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGV---NNFDEILEA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 243 SDVVMVARGDLGVEIGDPELVGVQKQLIRRARALNRTVITATQMMESMISAPMPTRAEVMDVANAVLDGTDAVMLSGETA 322
Cdd:cd00288 238 SDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 323 AGDYPVETVKSMAEVCIGAEKMAGINNQSNyRIDRTF---VTAEETVSMATIYSANHMeGIKGVVTLTESGRTALMMSRL 399
Cdd:cd00288 318 KGKYPVEAVKAMARICLEAEKALSHRVLFN-EMRRLTprpTSTTEAVAMSAVRAAFEL-GAKAIVVLTTSGRTARLVSKY 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 400 SADMPIYALSRNEGTLNRCTLYRGVTPIYFE----TEAEDSFDIALSTLTCLKEKGHLKFGDLVIVTQGDIMdVAGSTNC 475
Cdd:cd00288 396 RPNAPIIAVTRNEQTARQLHLYRGVYPVLFEepkpGWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPV-GSGSTNT 474
|
....*.
gi 2794280068 476 MRILPV 481
Cdd:cd00288 475 MRILTV 480
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
6-478 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 576.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 6 RKTKIVTTLGPSTDKGNVLEEIIKAGANIVRMNFSHGTSDDHIQRAEKVRTIAKRHGTQIAILGDLQGPKIRVSTFKDGK 85
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 86 IQLAVGDLFTLDSSLGLGEGNQEAVGLDYKELPNDVSAGDILLLDDGRVQLKVTKVEGCRVHTEVIIGGPLSNNKGINKK 165
Cdd:TIGR01064 81 VKLKKGDKVIITTDDIKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 166 GGGLSAEALTEKDKRDIVTAAQIKVDYLAVSFPRNGEDMHYARQLAREAGLE-AHLVAKVERAEtvaTVENMDDIIMASD 244
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKdVKIIAKIENQE---GVDNIDEIAEASD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 245 VVMVARGDLGVEIGDPELVGVQKQLIRRARALNRTVITATQMMESMISAPMPTRAEVMDVANAVLDGTDAVMLSGETAAG 324
Cdd:TIGR01064 238 GIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 325 DYPVETVKSMAEVCIGAEKMAGINNQSNYRIDRT--FVTAEETVSMATIYSANHMeGIKGVVTLTESGRTALMMSRLSAD 402
Cdd:TIGR01064 318 KYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDpkPSTITEAIALSAVEAAEKL-DAKAIVVLTESGRTARLLSKYRPN 396
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2794280068 403 MPIYALSRNEGTLNRCTLYRGVTPIYFETEAEDSFDIALSTLTCLKEKGHLKFGDLVIVTQGDIMDVAGSTNCMRI 478
Cdd:TIGR01064 397 APIIAVTPNERVARQLALYWGVFPFLVDEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
5-344 |
4.96e-155 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 444.12 E-value: 4.96e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 5 LRKTKIVTTLGPSTDKGNVLEEIIKAGANIVRMNFSHGTSDDHIQRAEKVRTIAKRHGTQIAILGDLQGPKIRVSTFKDG 84
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 85 K--IQLAVGD--LFTLDSSLGlGEGNQEAVGLDYKELPNDVSAGDILLLDDGRVQLKVT-KVEGCRVHTEVIIGGPLSNN 159
Cdd:pfam00224 81 KkdIELKAGDemIVSTDAKYK-GACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLsKDDDKTLVVEVLNGGVIGSR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 160 KGINKKGGGLSAEALTEKDKRDIVTAAQIKVDYLAVSFPRNGEDMHYARQLAREAGLEAHLVAKVERAETVAtveNMDDI 239
Cdd:pfam00224 160 KGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVN---NFDEI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 240 IMASDVVMVARGDLGVEIGDPELVGVQKQLIRRARALNRTVITATQMMESMISAPMPTRAEVMDVANAVLDGTDAVMLSG 319
Cdd:pfam00224 237 LEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSG 316
|
330 340
....*....|....*....|....*
gi 2794280068 320 ETAAGDYPVETVKSMAEVCIGAEKM 344
Cdd:pfam00224 317 ETAKGNYPVEAVRMMHEICLEAEKA 341
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
5-471 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 712.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 5 LRKTKIVTTLGPSTDKGNVLEEIIKAGANIVRMNFSHGTSDDHIQRAEKVRTIAKRHGTQIAILGDLQGPKIRVSTFKDG 84
Cdd:PRK05826 3 LRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKEG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 85 KIQLAVGDLFTLDSSLGlGEGNQEAVGLDYKELPNDVSAGDILLLDDGRVQLKVTKVEGCRVHTEVIIGGPLSNNKGINK 164
Cdd:PRK05826 83 KITLKTGDKFTLDTDQK-EEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGINI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 165 KGGGLSAEALTEKDKRDIVTAAQIKVDYLAVSFPRNGEDMHYARQLAREAGLE-AHLVAKVERAETVatvENMDDIIMAS 243
Cdd:PRK05826 162 PGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPhAKIIAKIERAEAV---DNIDEIIEAS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 244 DVVMVARGDLGVEIGDPELVGVQKQLIRRARALNRTVITATQMMESMISAPMPTRAEVMDVANAVLDGTDAVMLSGETAA 323
Cdd:PRK05826 239 DGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAA 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 324 GDYPVETVKSMAEVCIGAEKMAgINNQSNYRIDRTFVTAEETVSMATIYSANHMEGIKGVVTLTESGRTALMMSRLSADM 403
Cdd:PRK05826 319 GKYPVEAVEAMARICKGAEKEF-SINLSKHRLDRQFDRIDEAIAMSAMYAANHLKGVKAIVALTESGRTARLISRFRPGA 397
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2794280068 404 PIYALSRNEGTLNRCTLYRGVTPIYFETEAeDSFDIALSTLTCLKEKGHLKFGDLVIVTQGDIMDVAG 471
Cdd:PRK05826 398 PIFAVTRDEKTQRRLALYRGVYPVLFDSAA-DTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAG 464
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
5-481 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 705.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 5 LRKTKIVTTLGPSTDKGNVLEEIIKAGANIVRMNFSHGTSDDHIQRAEKVRTIAKRHGTQIAILGDLQGPKIRVSTFKDG 84
Cdd:COG0469 2 MRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 85 KIQLAVGDLFTLDSslGLGEGNQEAVGLDYKELPNDVSAGDILLLDDGRVQLKVTKVEGCRVHTEVIIGGPLSNNKGINK 164
Cdd:COG0469 82 PVELKKGDTFTLTT--DDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 165 KGGGLSAEALTEKDKRDIVTAAQIKVDYLAVSFPRNGEDMHYARQLAREAGLEAHLVAKVERAETVatvENMDDIIMASD 244
Cdd:COG0469 160 PGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAV---ENLDEIIEASD 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 245 VVMVARGDLGVEIGDPELVGVQKQLIRRARALNRTVITATQMMESMISAPMPTRAEVMDVANAVLDGTDAVMLSGETAAG 324
Cdd:COG0469 237 GIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVG 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 325 DYPVETVKSMAEVCIGAEKMAGINNQSNYRIDRTFVTAEETVSMATIYSANHMeGIKGVVTLTESGRTALMMSRLSADMP 404
Cdd:COG0469 317 KYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDL-GAKAIVAFTESGSTARRISRYRPKVP 395
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2794280068 405 IYALSRNEGTLNRCTLYRGVTPIYFE--TEAEDSFDIALSTltcLKEKGHLKFGDLVIVTQGDIMDVAGSTNCMRILPV 481
Cdd:COG0469 396 ILALTPNERTARRLALVWGVYPVLVDdvESTDEMIEEAVEA---LLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
5-481 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 587.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 5 LRKTKIVTTLGPSTDKGNVLEEIIKAGANIVRMNFSHGTSDDHIQRAEKVRTIAKRHGTQIAILGDLQGPKIRVSTFKDG 84
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 85 -KIQLAVGDLFTLDSSLGLGEGNQEAVGLDYKELPNDVSAGDILLLDDGRVQLKVTKVEGCR-VHTEVIIGGPLSNNKGI 162
Cdd:cd00288 81 kDISLKAGDKFLVTTDPAAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGGVLGSRKGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 163 NKKGGGLSAEALTEKDKRDIVTAAQIKVDYLAVSFPRNGEDMHYARQLAREAGLEAHLVAKVERAETVatvENMDDIIMA 242
Cdd:cd00288 161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGV---NNFDEILEA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 243 SDVVMVARGDLGVEIGDPELVGVQKQLIRRARALNRTVITATQMMESMISAPMPTRAEVMDVANAVLDGTDAVMLSGETA 322
Cdd:cd00288 238 SDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 323 AGDYPVETVKSMAEVCIGAEKMAGINNQSNyRIDRTF---VTAEETVSMATIYSANHMeGIKGVVTLTESGRTALMMSRL 399
Cdd:cd00288 318 KGKYPVEAVKAMARICLEAEKALSHRVLFN-EMRRLTprpTSTTEAVAMSAVRAAFEL-GAKAIVVLTTSGRTARLVSKY 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 400 SADMPIYALSRNEGTLNRCTLYRGVTPIYFE----TEAEDSFDIALSTLTCLKEKGHLKFGDLVIVTQGDIMdVAGSTNC 475
Cdd:cd00288 396 RPNAPIIAVTRNEQTARQLHLYRGVYPVLFEepkpGWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPV-GSGSTNT 474
|
....*.
gi 2794280068 476 MRILPV 481
Cdd:cd00288 475 MRILTV 480
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
6-478 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 576.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 6 RKTKIVTTLGPSTDKGNVLEEIIKAGANIVRMNFSHGTSDDHIQRAEKVRTIAKRHGTQIAILGDLQGPKIRVSTFKDGK 85
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 86 IQLAVGDLFTLDSSLGLGEGNQEAVGLDYKELPNDVSAGDILLLDDGRVQLKVTKVEGCRVHTEVIIGGPLSNNKGINKK 165
Cdd:TIGR01064 81 VKLKKGDKVIITTDDIKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 166 GGGLSAEALTEKDKRDIVTAAQIKVDYLAVSFPRNGEDMHYARQLAREAGLE-AHLVAKVERAEtvaTVENMDDIIMASD 244
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKdVKIIAKIENQE---GVDNIDEIAEASD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 245 VVMVARGDLGVEIGDPELVGVQKQLIRRARALNRTVITATQMMESMISAPMPTRAEVMDVANAVLDGTDAVMLSGETAAG 324
Cdd:TIGR01064 238 GIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 325 DYPVETVKSMAEVCIGAEKMAGINNQSNYRIDRT--FVTAEETVSMATIYSANHMeGIKGVVTLTESGRTALMMSRLSAD 402
Cdd:TIGR01064 318 KYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDpkPSTITEAIALSAVEAAEKL-DAKAIVVLTESGRTARLLSKYRPN 396
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2794280068 403 MPIYALSRNEGTLNRCTLYRGVTPIYFETEAEDSFDIALSTLTCLKEKGHLKFGDLVIVTQGDIMDVAGSTNCMRI 478
Cdd:TIGR01064 397 APIIAVTPNERVARQLALYWGVFPFLVDEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
5-344 |
4.96e-155 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 444.12 E-value: 4.96e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 5 LRKTKIVTTLGPSTDKGNVLEEIIKAGANIVRMNFSHGTSDDHIQRAEKVRTIAKRHGTQIAILGDLQGPKIRVSTFKDG 84
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 85 K--IQLAVGD--LFTLDSSLGlGEGNQEAVGLDYKELPNDVSAGDILLLDDGRVQLKVT-KVEGCRVHTEVIIGGPLSNN 159
Cdd:pfam00224 81 KkdIELKAGDemIVSTDAKYK-GACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLsKDDDKTLVVEVLNGGVIGSR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 160 KGINKKGGGLSAEALTEKDKRDIVTAAQIKVDYLAVSFPRNGEDMHYARQLAREAGLEAHLVAKVERAETVAtveNMDDI 239
Cdd:pfam00224 160 KGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVN---NFDEI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 240 IMASDVVMVARGDLGVEIGDPELVGVQKQLIRRARALNRTVITATQMMESMISAPMPTRAEVMDVANAVLDGTDAVMLSG 319
Cdd:pfam00224 237 LEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSG 316
|
330 340
....*....|....*....|....*
gi 2794280068 320 ETAAGDYPVETVKSMAEVCIGAEKM 344
Cdd:pfam00224 317 ETAKGNYPVEAVRMMHEICLEAEKA 341
|
|
| PRK06247 |
PRK06247 |
pyruvate kinase; Provisional |
5-478 |
5.01e-146 |
|
pyruvate kinase; Provisional
Pssm-ID: 180487 [Multi-domain] Cd Length: 476 Bit Score: 426.26 E-value: 5.01e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 5 LRKTKIVTTLGPSTDKGNVLEEIIKAGANIVRMNFSHGTSDDHIQRAEKVRTIAKRHGTQIAILGDLQGPKIRVSTFKDG 84
Cdd:PRK06247 4 NRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFADG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 85 KIQLAVGDLFTLDSSLGlgEGNQEAVGLDYKELPNDVSAGDILLLDDGRVQLKVTKVEGCRVHTEVIIGGPLSNNKGINK 164
Cdd:PRK06247 84 KVQLANGQTFRLDVDDA--PGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGVSL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 165 KGGGLSAEALTEKDKRDIVTAAQIKVDYLAVSFPRNGEDMHYARQLAREaglEAHLVAKVERAETVatvENMDDIIMASD 244
Cdd:PRK06247 162 PGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGG---RVPVMAKIEKPQAI---DRLEAIVEASD 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 245 VVMVARGDLGVEIGDPELVGVQKQLIRRARALNRTVITATQMMESMISAPMPTRAEVMDVANAVLDGTDAVMLSGETAAG 324
Cdd:PRK06247 236 AIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASG 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 325 DYPVETVKSMAEVCIGAEkmaginNQSNYR--IDRTFVTAEETVSMATIYSANHMEGI---KGVVTLTESGRTALMMSRL 399
Cdd:PRK06247 316 KYPVEAVRTMARIIRQVE------RDPTYPplIHAQRPQPEATKRDAISYAARDIAERldlAALVAYTSSGDTALRAARE 389
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2794280068 400 SADMPIYALSRNEGTLNRCTLYRGVTPIYFEtEAEDSFDIALSTLTCLKEKGHLKFGDLVIVTQGDIMDVAGSTNCMRI 478
Cdd:PRK06247 390 RPPLPILALTPNPETARRLALTWGVHCVVVD-DARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGTPGSTNMLRI 467
|
|
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
6-478 |
4.07e-144 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 425.49 E-value: 4.07e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 6 RKTKIVTTLGPSTDKGNVLEEIIKAGANIVRMNFSHGTSDDHIQRAEKVRTIAKRHGTQIAILGDLQGPKIRVSTFKDGK 85
Cdd:PRK06354 8 RRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFEDGP 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 86 IQLAVGDLFTLDSSLGlgEGNQEAVGLDYKELPNDVSAGDILLLDDGRVQLKVTKVEGC--RVHTEVIIGGPLSNNKGIN 163
Cdd:PRK06354 88 IELKTGDEFILTSREV--LGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKAdgELHCKVLVGGVLSNKKGVN 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 164 KKGGGLSAEALTEKDKRDIVTAAQIKVDYLAVSFPRNGEDMHYARQL-AREAGLEAHLVAKVERAETVatvENMDDIIMA 242
Cdd:PRK06354 166 FPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELiEEHNGKHIPIIAKIEKQEAI---DNIDAILEL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 243 SDVVMVARGDLGVEIGDPELVGVQKQLIRRARALNRTVITATQMMESMISAPMPTRAEVMDVANAVLDGTDAVMLSGETA 322
Cdd:PRK06354 243 CDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETA 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 323 AGDYPVETVKSMAEVCIGAEK-MAGINNQSNYRIDRTFVTaeETVSMATIYSANHMeGIKGVVTLTESGRTALMMSRLSA 401
Cdd:PRK06354 323 AGDYPVEAVQTMATIAVRIEKdLPYRDILSKRPEFTTTIT--NAISQAVSHIALQL-DAAAIVTLTKSGATARNVSKYRP 399
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2794280068 402 DMPIYALSRNEGTLNRCTLYRGVTPIYFETEA--EDSFDIALSTltcLKEKGHLKFGDLVIVTQGDIMDVAGSTNCMRI 478
Cdd:PRK06354 400 KTPILAVTPNESVARRLQLVWGVTPLLVLDAPstDETFDAAINV---AQESGLLKQGDLVVITAGTLVGESGSTDLMKV 475
|
|
| PRK09206 |
PRK09206 |
pyruvate kinase PykF; |
5-474 |
1.33e-115 |
|
pyruvate kinase PykF;
Pssm-ID: 181699 [Multi-domain] Cd Length: 470 Bit Score: 348.20 E-value: 1.33e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 5 LRKTKIVTTLGPSTDKGNVLEEIIKAGANIVRMNFSHGTSDDHIQRAEKVRTIAKRHGTQIAILGDLQGPKIRVSTFKDG 84
Cdd:PRK09206 1 MKKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKLEGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 85 K-IQLAVGDLFTL--DSSLglgEGNQEAVGLDYKELPNDVSAGDILLLDDGRVQLKVTKVEGCRVHTEVIIGGPLSNNKG 161
Cdd:PRK09206 81 NdVSLKAGQTFTFttDKSV---VGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGENKG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 162 INKKGGGLSAEALTEKDKRDIVTAAQIKVDYLAVSFPRNGEDMHYARQLAREAGLE-AHLVAKVERAETVatvENMDDII 240
Cdd:PRK09206 158 VNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGEnIQIISKIENQEGL---NNFDEIL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 241 MASDVVMVARGDLGVEIGDPELVGVQKQLIRRARALNRTVITATQMMESMISAPMPTRAEVMDVANAVLDGTDAVMLSGE 320
Cdd:PRK09206 235 EASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGE 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 321 TAAGDYPVETVKSMAEVCIGAEKMagINNQSNYRIDRTFVTAEETVSMATIYSANHMEGiKGVVTLTESGRTALMMSRLS 400
Cdd:PRK09206 315 SAKGKYPLEAVSIMATICERTDRV--MNSRLESNNDNRKLRITEAVCRGAVETAEKLDA-PLIVVATQGGKSARSVRKYF 391
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2794280068 401 ADMPIYALSRNEGTLNRCTLYRGVTPIYFETEA--EDSFDIALSTltcLKEKGHLKFGDLVIVTQGDIMDvAGSTN 474
Cdd:PRK09206 392 PDATILALTTNEKTARQLVLSKGVVPQLVKEIAstDDFYRLGKEL---ALQSGLAQKGDVVVMVSGALVP-SGTTN 463
|
|
| PLN02461 |
PLN02461 |
Probable pyruvate kinase |
7-460 |
1.48e-100 |
|
Probable pyruvate kinase
Pssm-ID: 215255 [Multi-domain] Cd Length: 511 Bit Score: 310.76 E-value: 1.48e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 7 KTKIVTTLGPSTDKGNVLEEIIKAGANIVRMNFSHGTSDDHIQRAEKVRTIAKRHGTQIAILGDLQGPKIRVSTFKDGK- 85
Cdd:PLN02461 22 KTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTGFLKDGKp 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 86 IQLAVGDLFTL--DSSLglgEGNQEAVGLDYKELPNDVSAGDILLLDDGRVQLKV--TKVEG----CRVHTEVIIGgpls 157
Cdd:PLN02461 102 VQLKQGQEITIttDYSI---KGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVlsCDVEAgtvrCRCENSAMLG---- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 158 NNKGINKKGGGLSAEALTEKDKRDIVT-AAQIKVDYLAVSFPRNGEDMHYARQLAREAGLEAHLVAKVERAETVAtveNM 236
Cdd:PLN02461 175 ERKNVNLPGVVVDLPTLTEKDKEDILQwGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLD---NF 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 237 DDIIMASDVVMVARGDLGVEIGDPELVGVQKQLIRRARALNRTVITATQMMESMISAPMPTRAEVMDVANAVLDGTDAVM 316
Cdd:PLN02461 252 DDILAESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVM 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 317 LSGETAAGDYPVETVKSMAEVCIGAEkmAGINNQSNYR--IDRTFV--TAEETVSMATIYSANHMeGIKGVVTLTESGRT 392
Cdd:PLN02461 332 LSGETAAGAYPELAVKTMARICREAE--ASLDYGALFKeiMRSAPLpmSPLESLASSAVRTANKV-KASLIVVLTRGGTT 408
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 393 ALMMSRLSADMPIYAL-------------SRNEGTLNRCTLYRGVTPIYFETEAEDSfdIALSTLTCL-------KEKGH 452
Cdd:PLN02461 409 ARLVAKYRPAVPILSVvvpeittdsfdwsCSDEAPARHSLIYRGLIPVLAEGSAKAT--DSESTEEILeaaiehaKKKGL 486
|
....*...
gi 2794280068 453 LKFGDLVI 460
Cdd:PLN02461 487 CKPGDSVV 494
|
|
| PTZ00066 |
PTZ00066 |
pyruvate kinase; Provisional |
6-481 |
6.32e-98 |
|
pyruvate kinase; Provisional
Pssm-ID: 173361 [Multi-domain] Cd Length: 513 Bit Score: 304.38 E-value: 6.32e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 6 RKTKIVTTLGPSTDKGNVLEEIIKAGANIVRMNFSHGTSDDHIQRAEKVR-TIAKRHGTQIAILGDLQGPKIRVSTFKDG 84
Cdd:PTZ00066 38 KKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVReAAKARPNANLGILLDTKGPEIRTGFLKNH 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 85 K-IQLAVGDLFTLDSSLGLgEGNQEAVGLDYKELPNDVSAGDILLLDDGRVQLKVTKVEGCRVHTEVIIGGPLSNNKGIN 163
Cdd:PTZ00066 118 KpITLKEGQTLKITTDYTF-LGDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGERKNMN 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 164 KKGGGLSAEALTEKDKRDIVT-AAQIKVDYLAVSFPRNGEDMHYARQLAREAGLEAHLVAKVERAETVAtveNMDDIIMA 242
Cdd:PTZ00066 197 LPGVKVELPVIGEKDKNDILNfAIPMGCDFIALSFVQSADDVRLCRQLLGERGRHIKIIPKIENIEGLI---NFDEILAE 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 243 SDVVMVARGDLGVEIgDPELVGV-QKQLIRRARALNRTVITATQMMESMISAPMPTRAEVMDVANAVLDGTDAVMLSGET 321
Cdd:PTZ00066 274 SDGIMVARGDLGMEI-PPEKVFLaQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGET 352
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 322 AAGDYPVETVKSMAEVCIGAEkmaginNQSNYRI--------DRTFVTAEETVSMATIYSANHMEGiKGVVTLTESGRTA 393
Cdd:PTZ00066 353 ANGKFPVEAVNIMAKICFEAE------TCIDYRVlyhaihlaVPTPVSVQEAVARSAVETAEDINA-KLIIALTETGNTA 425
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 394 LMMSRLSADMPIYALSRNEGTLNRCTLYRGVTPIYFETEAEDSFDIAlSTLTCLKEKGHLKFGDLVIVTQGDIMDVAGST 473
Cdd:PTZ00066 426 RLISKYRPSCTILALSASPSVVKSLSVARGVTTYVVNSFQGTDVVIR-NAIALAKERGLVESGDSAIAVHGVKEEVAGSS 504
|
....*...
gi 2794280068 474 NCMRILPV 481
Cdd:PTZ00066 505 NLMKVVKI 512
|
|
| PLN02623 |
PLN02623 |
pyruvate kinase |
6-463 |
1.94e-88 |
|
pyruvate kinase
Pssm-ID: 215334 [Multi-domain] Cd Length: 581 Bit Score: 281.82 E-value: 1.94e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 6 RKTKIVTTLGPSTDKGNVLEEIIKAGANIVRMNFSHGTSDDHIQRAEKVRTI-AKRHGTQIAILGDLQGPKIRVSTFKDg 84
Cdd:PLN02623 110 RKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYnAQSKDNVIAIMLDTKGPEVRSGDLPQ- 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 85 KIQLAVGDLFTLdsSLGLGEGNQEAVGLDYKELPNDVSAGDILLLDDGRVQLKVTKVEGCRVHTEVIIGGPLSNNKGINK 164
Cdd:PLN02623 189 PIMLEEGQEFTF--TIKRGVSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKCEVVDGGELKSRRHLNV 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 165 KGGGLSAEALTEKDKRDIVTAAQIKVDYLAVSFPRNGEDMHYARQLAREAGLEAHLVAKVERAETVAtveNMDDIIMASD 244
Cdd:PLN02623 267 RGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNADIHVIVKIESADSIP---NLHSIITASD 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 245 VVMVARGDLGVEIGDPELVGVQKQLIRRARALNRTVITATQMMESMISAPMPTRAEVMDVANAVLDGTDAVMLSGETAAG 324
Cdd:PLN02623 344 GAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHG 423
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 325 DYPVETVKSMAEVCIGAEKMAgINNQSNYRIDRTFVT--AEETVSMATIYSANHMEGIkgvVTLTESGRTALMMSRLSAD 402
Cdd:PLN02623 424 KFPLKAVKVMHTVALRTEATL-PEGTTPPNLGQAFKNhmSEMFAFHATMMANTLGTSI---IVFTRTGFMAILLSHYRPS 499
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2794280068 403 MPIYALSRNEGTLNRCTLYRGVTPIY--FETEAEDSFDIALSTltcLKEKGHLKFGDLVIVTQ 463
Cdd:PLN02623 500 GTIFAFTNEKRIQQRLALYQGVCPIYmqFSDDAEETFARALSL---LLNKGMVKEGEEVALVQ 559
|
|
| PRK06739 |
PRK06739 |
pyruvate kinase; Validated |
11-342 |
4.09e-86 |
|
pyruvate kinase; Validated
Pssm-ID: 180676 [Multi-domain] Cd Length: 352 Bit Score: 268.35 E-value: 4.09e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 11 VTTLGPSTDKGNVLEEIIKAGANIVRMNFSHGTSDDHIQRAEKVRTIakrhGTQIAILGDLQGPKIRVSTFKDGKIQLAV 90
Cdd:PRK06739 6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSL----DDSIKILGDVQGPKIRLGEIKGEQITLQA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 91 GDLFTLDSSLGlgEGNQEAVGLDYKELPNDVSAGDILLLDDGRVQLKVTKVEGCRVHTEVIIGGPLSNNKGINKKGGGLS 170
Cdd:PRK06739 82 GDSFILHTQPV--TGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHKGVNLPGAIVR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 171 AEALTEKDKRDIVTAAQIKVDYLAVSFPRNGEDMHYARQLAREAGLEA-HLVAKVEraeTVATVENMDDIIMASDVVMVA 249
Cdd:PRK06739 160 LPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSpNLIAKIE---TMEAIENFQDICKEADGIMIA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 250 RGDLGVEIGDPELVGVQKQLIRRARALNRTVITATQMMESMISAPMPTRAEVMDVANAVLDGTDAVMLSGETAAGDYPVE 329
Cdd:PRK06739 237 RGDLGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIE 316
|
330
....*....|...
gi 2794280068 330 TVKSMAEVCIGAE 342
Cdd:PRK06739 317 SVSTLRLVSEFAE 329
|
|
| PTZ00300 |
PTZ00300 |
pyruvate kinase; Provisional |
33-482 |
9.37e-82 |
|
pyruvate kinase; Provisional
Pssm-ID: 140321 [Multi-domain] Cd Length: 454 Bit Score: 260.75 E-value: 9.37e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 33 NIVRMNFSHGTSDDHIQRAEKVRTIAKRHGTQIAILGDLQGPKIRVSTFKDGKIQLAVGD--LFTLDSSLGlGEGNQEAV 110
Cdd:PTZ00300 2 SVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGGEAVMERGAtcYVTTDPAFA-DKGTKDKF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 111 GLDYKELPNDVSAGDILLLDDGRVQLKVTKVEG-----CRV---HTeviiggpLSNNKGINKKGGGLSAEALTEKDKRDI 182
Cdd:PTZ00300 81 YIDYQNLSKVVRPGGYIYIDDGILILHVQSHEDeqtlkCTVtnaHT-------ISDRRGVNLPGCDVDLPAVSAKDCADL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 183 VTAAQIKVDYLAVSFPRNGEDMHYARQLAREAGLEAHLVAKVERAETVatvENMDDIIMASDVVMVARGDLGVEIGDPEL 262
Cdd:PTZ00300 154 QFGVEQGVDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGV---QNIDSIIEESDGIMVARGDLGVEIPAEKV 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 263 VGVQKQLIRRARALNRTVITATQMMESMISAPMPTRAEVMDVANAVLDGTDAVMLSGETAAGDYPVETVKSMAEVCIgaE 342
Cdd:PTZ00300 231 VVAQKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICL--E 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 343 KMAGINN----QSNYRIDRTFVTAEETVSMATIYSANHMEGiKGVVTLTESGRTALMMSRLSADMPIYALSRNEGTLNRC 418
Cdd:PTZ00300 309 AQSAVNEyvffNSIKKLQPIPMSAEEAVCSSAVNSVYETKA-KALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQL 387
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2794280068 419 TLYRGVTPIYFETEA----EDSFDIALSTLTCLKEKGHLKFGDLVIVTQGDiMDVAGSTNCMRILPVT 482
Cdd:PTZ00300 388 NITQGVESVFFDAERlghdEGKEQRVAMGVGFAKSKGYVQSGDLMVVVHAD-HKVKGYANQTRIILVS 454
|
|
| PLN02762 |
PLN02762 |
pyruvate kinase complex alpha subunit |
5-461 |
6.65e-67 |
|
pyruvate kinase complex alpha subunit
Pssm-ID: 215407 [Multi-domain] Cd Length: 509 Bit Score: 223.08 E-value: 6.65e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 5 LRKTKIVTTLGPSTDKGNVLEEIIKAGANIVRMNFSHGTSDDHIQRAEKVRTIAKRHGTQIAILGDLQGPKIRVSTF--- 81
Cdd:PLN02762 24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEIHMGDLgga 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 82 -----KDGKIQLavgdlFT---LDSSLglgegNQEAVGLDYKELPNDVSAGDILLLDDGRVQLKVTKVEGCRVHTEVIIG 153
Cdd:PLN02762 104 ssakaEDGEEWT-----FTvrkFDGSR-----PEFTIQVNYDGFAEDVKVGDELVVDGGMVRFEVIEKIGPDVKCKCTDP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 154 GPL---------SNNKGINKKGGGLSAeaLTEKDKRDIVTAAQIKVDYLAVSFPRNGEDMHYARQL--AREAGLEAHLVA 222
Cdd:PLN02762 174 GLLlpranltfwRDGSLVRERNAMLPT--ISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYiaARSRDSDIGVIA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 223 KVERAETVatvENMDDIIMASDVVMVARGDLGVEIGDPELVGVQKQLIRRARALNRTVITATQMMESMISAPMPTRAEVM 302
Cdd:PLN02762 252 KIESLDSL---KNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVA 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 303 DVANAVLDGTDAVMLSGETAAGDYP------VETVKSMAEVCIGAEKMAGINNQSNYRIDRTFVTAEETVSMATiYSANH 376
Cdd:PLN02762 329 DVSEAVRQRADALMLSGESAMGLYPekalsvLRSVSLRMELWSREEKRHEALELPQLSSSLSDRISEEICNSAA-KMANN 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 377 MeGIKGVVTLTESGRTALMMSRLSADMPIYALSRNEGTLNRCTLYRGVTPIYFEtEAEDSFDIALSTLTCLKEKGHLKFG 456
Cdd:PLN02762 408 L-GVDAIFVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLD-FSDDMESNLNKTFSLLKARGMIKSG 485
|
....*
gi 2794280068 457 DLVIV 461
Cdd:PLN02762 486 DLVIA 490
|
|
| PLN02765 |
PLN02765 |
pyruvate kinase |
8-465 |
1.50e-63 |
|
pyruvate kinase
Pssm-ID: 215409 [Multi-domain] Cd Length: 526 Bit Score: 214.92 E-value: 1.50e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 8 TKIVTTLGPSTDKGNVLEEIIKAGANIVRMNFSHGTSDDHIQRAEKVRTIAKRHGTQIAILGDLQGPKIRVSTFKDGKIQ 87
Cdd:PLN02765 30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQVINKTEKPIS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 88 LAVGDLFTLDSSLGLgEGNQEAVGLDYKELPNDVSAGDILLL--------DDGRVQLKVTKVEG----CRVHTEVIIGGP 155
Cdd:PLN02765 110 LKAGNTVTLTPDQSK-EASSEVLPINFPGLAKAVKPGDTIFVgqylftgsETTSVWLEVDEVKGddvvCTVKNSATLAGS 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 156 L----SNNKGInkkggglSAEALTEKDKRDIVT-AAQIKVDYLAVSFPRNGEDMHYARQLAREAGL-EAHLVAKVERAET 229
Cdd:PLN02765 189 LftlhVSQVRI-------DLPTLSEKDKEVISTwGVPNKIDFLSLSYTRHAEDVREAREFLSSLGLsQTQIFAKIENVEG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 230 VAtveNMDDIIMASDVVMVARGDLGVEIgDPELVGV-QKQLIRRARALNRTVITaTQMMESMISAPMPTRAEVMDVANAV 308
Cdd:PLN02765 262 LT---HFDEILQEADGIILSRGNLGIDL-PPEKVFLfQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAV 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 309 LDGTDAVMLSGETAAGDYPVETVKSMAEVCIGAEKMagINNQSNYRIDRTFV----TAEETVSMATIYSANHMeGIKGVV 384
Cdd:PLN02765 337 LDGADAILLGAETLRGLYPVETISTVGRICAEAEKV--FNQDLYFKKTVKYVgepmSHLESIASSAVRAAIKV-KASVII 413
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 385 TLTESGRTALMMSRLSADMPIYA-----LSRN------EGTLN--RCTLYRGVTPIYFETEAEDS---------FDIALS 442
Cdd:PLN02765 414 VFTSSGRAARLIAKYRPTMPVLSvviprLKTNqlkwsfTGAFQarQCLIVRGLFPMLADPRHSAEstsatnesvLKVALD 493
|
490 500
....*....|....*....|....*
gi 2794280068 443 TltcLKEKGHLKFGDLVIVTQ--GD 465
Cdd:PLN02765 494 H---GKAAGVIKSHDRVVVCQkvGD 515
|
|
| PK_C |
pfam02887 |
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ... |
364-479 |
1.50e-36 |
|
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.
Pssm-ID: 460738 [Multi-domain] Cd Length: 114 Bit Score: 130.68 E-value: 1.50e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 364 ETVSMATIYSANHMeGIKGVVTLTESGRTALMMSRLSADMPIYALSRNEGTLNRCTLYRGVTPIYFEtEAEDSFDIALST 443
Cdd:pfam02887 1 EAIAHAAVEAAEEL-GAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFD-EAETTDEMLRRA 78
|
90 100 110
....*....|....*....|....*....|....*.
gi 2794280068 444 LTCLKEKGHLKFGDLVIVTQGDIMDVAGSTNCMRIL 479
Cdd:pfam02887 79 VKVAKEAGLVKKGDLVVITAGVPFGVSGTTNTLKVI 114
|
|
| PRK08187 |
PRK08187 |
pyruvate kinase; Validated |
4-337 |
9.59e-35 |
|
pyruvate kinase; Validated
Pssm-ID: 236178 Cd Length: 493 Bit Score: 135.91 E-value: 9.59e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 4 ELRKTKIVTTLgPS---TDKGNVLEeIIKAGANIVRMNFSHGTSDDHIQRAEKVRTIAKRHGTQIAILGDLQGPKIRVST 80
Cdd:PRK08187 131 AARRTRIMVTL-PSeaaDDPDFVLR-LAERGMDCARINCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRTGA 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 81 F--KDGKIQLAVGDLFTLDSSLGLGEGNQE--AVGLDYKELPNDVSAGDILLLDDGRVQLKVTKVEGCRVHTEVIIGGP- 155
Cdd:PRK08187 209 VagPLGKTRLYTGDRLALVAQGPPRRIDEEhfQVTCTLPEILARLAVGARVWIDDGKLGARVERVGPGGALLEVTHARPk 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 156 ---LSNNKGINKKGGGLSAEALTEKDKRDIVTAAQiKVDYLAVSFPRNGEDMH-YARQLAREAGLEAHLVAKVERAETVA 231
Cdd:PRK08187 289 glkLKPEKGLNFPDTALDLPALTEKDRADLDFVAR-HADLVGYSFVQSPGDVEaLQAALAARRPDDWRKLGLVLKIETPR 367
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 232 TVENMDDIIMASD-----VVMVARGDLGVEIGDPELVGVQKQLIRRARALNRTVITATQMMESMISAPMPTRAEVMDVAN 306
Cdd:PRK08187 368 AVANLPELIVQAAgrqpfGVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDAAM 447
|
330 340 350
....*....|....*....|....*....|.
gi 2794280068 307 AvlDGTDAVMLSgetaAGDYPVETVKSMAEV 337
Cdd:PRK08187 448 A--ARAECVMLN----KGPYLVEAVTFLDDL 472
|
|
| PykA2 |
COG3848 |
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms]; |
279-481 |
1.64e-34 |
|
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
Pssm-ID: 443058 Cd Length: 321 Bit Score: 131.56 E-value: 1.64e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 279 TVITATQMMESMISAPMPTRAEVMDVANAVLDGTDAVMLSGETAAGDYPVETVKSMAEVCIGAEKMAGINNQSNYRIDRT 358
Cdd:COG3848 8 PVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYREQRVPRAKES 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 359 FVTAEETVSMATIYSANHMeGIKGVVTLTESGRTALMMSRLSADMPIYALSRNEGTLNRCTLYRGVTPIYFE--TEAEDS 436
Cdd:COG3848 88 STTITDAISHAVATTAADL-GAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVEesASTDEM 166
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 2794280068 437 FDIALSTLTclkEKGHLKFGDLVIVTQGDIMDVAGSTNCMRILPV 481
Cdd:COG3848 167 FAVAVALAL---EAGLVKDGDLVVITAGVPVGVSGTTNLLKVHVV 208
|
|
| PRK14725 |
PRK14725 |
pyruvate kinase; Provisional |
81-332 |
2.08e-30 |
|
pyruvate kinase; Provisional
Pssm-ID: 237804 Cd Length: 608 Bit Score: 124.68 E-value: 2.08e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 81 FKDGKIQLAVGDLFTLDSSL-----GLGEGNQEAVGLDYKELPNDVSAGDILLLDDGRVQLKVTKVEGCRVHTEVIIGGP 155
Cdd:PRK14725 328 PVEQKLRLKVGDRLVLTRDDapgdpAQGDAPPARISCTLPEAFRAARVGERVWFDDGKIGAVVVKVEADEVELRITHARP 407
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 156 ----LSNNKGINKKGGGLSAEALTEKDKRDIVTAAQIkVDYLAVSFPRNGEDMHYARQ-LAREAGLEAHLVAKVEraeTV 230
Cdd:PRK14725 408 ggskLKAGKGINLPDSHLPLPALTDKDLEDLAFVAKH-ADIVALSFVRSPEDVRLLLDaLEKLGADDLGVVLKIE---TR 483
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2794280068 231 ATVENMDDIIMAS----DV-VMVARGDLGVEIGDPELVGVQKQLIRRARALNRTVITATQMMESMISAPMPTRAEVMDVA 305
Cdd:PRK14725 484 RAFENLPRILLEAmrhpRFgVMIARGDLAVEVGFERLAEVQEEILWLCEAAHVPVIWATQVLESLAKKGLPSRAEITDAA 563
|
250 260
....*....|....*....|....*..
gi 2794280068 306 NAVLdgTDAVMLSgetaAGDYPVETVK 332
Cdd:PRK14725 564 MALR--AECVMLN----KGPHIVEAVR 584
|
|
| |
