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Conserved domains on  [gi|2796385883|ref|WP_373116668|]
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nucleotide exchange factor GrpE [Holdemania massiliensis]

Protein Classification

nucleotide exchange factor GrpE( domain architecture ID 1562)

nucleotide exchange factor GrpE functions as a nucleotide exchange factor for DnaK and participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may also function as a thermosensor

CATH:  3.90.20.20|2.30.22.10
Gene Ontology:  GO:0000774|GO:0051087|GO:0006457|GO:0042803
SCOP:  4003783|4002724

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GrpE super family cl03075
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 35-191 1.28e-62

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


The actual alignment was detected with superfamily member PRK14140:

Pssm-ID: 446000 [Multi-domain]  Cd Length: 191  Bit Score: 192.14  E-value: 1.28e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  35 SKKNEIEELKTRISELEGENVRLKNEYLKAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERALAIEPTPE-T 113
Cdd:PRK14140   34 SEAELLDEEQAKIAELEAKLDELEERYLRLQADFENYKRRIQKENEAAEKYRAQSLASDLLPALDNFERALQIEADDEqT 113

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2796385883 114 ESYRKGVEMIYQQLIHALTKEGVSEIEALGKEFDPNFHQALMMEAVEGAEPNHVVEVLQKGYLLKDRILRAAMVKVSE 191
Cdd:PRK14140  114 KSLLKGVEMVHRQLLEALKKEGVEVIEAVGEQFDPNLHQAVMQDEDEDFESNEVVEELQKGYKLKDRVIRPSMVKVNQ 191
 
Name Accession Description Interval E-value
PRK14140 PRK14140
heat shock protein GrpE; Provisional
 35-191 1.28e-62

heat shock protein GrpE; Provisional


Pssm-ID: 237622 [Multi-domain]  Cd Length: 191  Bit Score: 192.14  E-value: 1.28e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  35 SKKNEIEELKTRISELEGENVRLKNEYLKAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERALAIEPTPE-T 113
Cdd:PRK14140   34 SEAELLDEEQAKIAELEAKLDELEERYLRLQADFENYKRRIQKENEAAEKYRAQSLASDLLPALDNFERALQIEADDEqT 113

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2796385883 114 ESYRKGVEMIYQQLIHALTKEGVSEIEALGKEFDPNFHQALMMEAVEGAEPNHVVEVLQKGYLLKDRILRAAMVKVSE 191
Cdd:PRK14140  114 KSLLKGVEMVHRQLLEALKKEGVEVIEAVGEQFDPNLHQAVMQDEDEDFESNEVVEELQKGYKLKDRVIRPSMVKVNQ 191
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 48-191 2.17e-62

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 189.98  E-value: 2.17e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  48 SELEGENVRLKNEYLKAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERAL-AIEPTPETESYRKGVEMIYQQ 126
Cdd:COG0576     2 EELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALaAAEEDEDVKSLLEGVEMTLKQ 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2796385883 127 LIHALTKEGVSEIEALGKEFDPNFHQALMMEAVEGAEPNHVVEVLQKGYLLKDRILRAAMVKVSE 191
Cdd:COG0576    82 LLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVLRPAMVVVAK 146
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 57-189 6.47e-61

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 185.79  E-value: 6.47e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  57 LKNEYLKAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERALAIEPT-PETESYRKGVEMIYQQLIHALTKEG 135
Cdd:cd00446     3 LKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKeEELKNLLEGVEMTLKQLLKVLEKHG 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2796385883 136 VSEIEALGKEFDPNFHQALMMEAVEGAEPNHVVEVLQKGYLLKDRILRAAMVKV 189
Cdd:cd00446    83 VEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
36-191 2.99e-58

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 180.11  E-value: 2.99e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  36 KKNEIEELKTRISELEGENVRLKNEYLKAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERALAIEPTPET-E 114
Cdd:pfam01025   9 LTDEIESLEEEIEELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSAPENEDvK 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2796385883 115 SYRKGVEMIYQQLIHALTKEGVSEIEALGKEFDPNFHQALMMEAVEGAEPNHVVEVLQKGYLLKDRILRAAMVKVSE 191
Cdd:pfam01025  89 SLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLHDRVLRPAMVVVSK 165
 
Name Accession Description Interval E-value
PRK14140 PRK14140
heat shock protein GrpE; Provisional
 35-191 1.28e-62

heat shock protein GrpE; Provisional


Pssm-ID: 237622 [Multi-domain]  Cd Length: 191  Bit Score: 192.14  E-value: 1.28e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  35 SKKNEIEELKTRISELEGENVRLKNEYLKAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERALAIEPTPE-T 113
Cdd:PRK14140   34 SEAELLDEEQAKIAELEAKLDELEERYLRLQADFENYKRRIQKENEAAEKYRAQSLASDLLPALDNFERALQIEADDEqT 113

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2796385883 114 ESYRKGVEMIYQQLIHALTKEGVSEIEALGKEFDPNFHQALMMEAVEGAEPNHVVEVLQKGYLLKDRILRAAMVKVSE 191
Cdd:PRK14140  114 KSLLKGVEMVHRQLLEALKKEGVEVIEAVGEQFDPNLHQAVMQDEDEDFESNEVVEELQKGYKLKDRVIRPSMVKVNQ 191
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 48-191 2.17e-62

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 189.98  E-value: 2.17e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  48 SELEGENVRLKNEYLKAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERAL-AIEPTPETESYRKGVEMIYQQ 126
Cdd:COG0576     2 EELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALaAAEEDEDVKSLLEGVEMTLKQ 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2796385883 127 LIHALTKEGVSEIEALGKEFDPNFHQALMMEAVEGAEPNHVVEVLQKGYLLKDRILRAAMVKVSE 191
Cdd:COG0576    82 LLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVLRPAMVVVAK 146
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 57-189 6.47e-61

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 185.79  E-value: 6.47e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  57 LKNEYLKAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERALAIEPT-PETESYRKGVEMIYQQLIHALTKEG 135
Cdd:cd00446     3 LKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKeEELKNLLEGVEMTLKQLLKVLEKHG 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2796385883 136 VSEIEALGKEFDPNFHQALMMEAVEGAEPNHVVEVLQKGYLLKDRILRAAMVKV 189
Cdd:cd00446    83 VEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
36-191 2.99e-58

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 180.11  E-value: 2.99e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  36 KKNEIEELKTRISELEGENVRLKNEYLKAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERALAIEPTPET-E 114
Cdd:pfam01025   9 LTDEIESLEEEIEELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSAPENEDvK 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2796385883 115 SYRKGVEMIYQQLIHALTKEGVSEIEALGKEFDPNFHQALMMEAVEGAEPNHVVEVLQKGYLLKDRILRAAMVKVSE 191
Cdd:pfam01025  89 SLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLHDRVLRPAMVVVSK 165
PRK14162 PRK14162
heat shock protein GrpE; Provisional
 36-191 4.29e-45

heat shock protein GrpE; Provisional


Pssm-ID: 237631 [Multi-domain]  Cd Length: 194  Bit Score: 147.67  E-value: 4.29e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  36 KKNEIEELKTRISELEGENVRLKNEYLKAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERALAIEPTPE-TE 114
Cdd:PRK14162   37 KQNPVEDLEKEIADLKAKNKDLEDKYLRSQAEIQNMQNRYAKERAQLIKYESQSLAKDVLPAMDNLERALAVKADDEaAK 116

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2796385883 115 SYRKGVEMIYQQLIHALTKEGVSEIEALGKEFDPNFHQALMMEAVEGAEP-NHVVEVLQKGYLLKDRILRAAMVKVSE 191
Cdd:PRK14162  117 QLKKGVQMTLDHLVKALKDHGVTEIKADGEKFDPTLHQAVQTVAAENDDQkDHVVQVLQKGYQYKDRTLRPAMVVVAQ 194
PRK14139 PRK14139
heat shock protein GrpE; Provisional
 38-190 2.98e-44

heat shock protein GrpE; Provisional


Pssm-ID: 237621 [Multi-domain]  Cd Length: 185  Bit Score: 145.12  E-value: 2.98e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  38 NEIEELKTRISELEGENVRLKNEYLKAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERALAIEpTPETESYR 117
Cdd:PRK14139   32 DAAPALEAELAEAEAKAAELQDSFLRAKAETENVRRRAQEDVAKAHKFAIESFAESLLPVKDSLEAALADE-SGDLEKLR 110

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2796385883 118 KGVEMIYQQLIHALTKEGVSEIEALGKEFDPNFHQALMMEAVEGaEPNHVVEVLQKGYLLKDRILRAAMVKVS 190
Cdd:PRK14139  111 EGVELTLKQLTSAFEKGRVVEINPVGEKFDPHQHQAISMVPAEQ-EPNTVVAVLQKGYTIADRVLRPALVTVA 182
PRK14150 PRK14150
heat shock protein GrpE; Provisional
 40-190 8.83e-37

heat shock protein GrpE; Provisional


Pssm-ID: 184539 [Multi-domain]  Cd Length: 193  Bit Score: 126.19  E-value: 8.83e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  40 IEELKTRISELEGENvrlKNEYLKAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERALAIEPT--PETESYR 117
Cdd:PRK14150   43 IAELEAQLAEAQAEE---RDSVLRARAEVENIRRRAEQDVEKAHKFALEKFANELLPVIDNLERALQAADKenEALKALI 119

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2796385883 118 KGVEMIYQQLIHALTKEGVSEIEALGKEFDPNFHQALMMEAVEGAEPNHVVEVLQKGYLLKDRILRAAMVKVS 190
Cdd:PRK14150  120 EGVELTLKSLLDTVAKFGVEVVGPVGEPFNPEVHQAISMQESEDHEPNTVMMVMQKGYTLNGRLLRPAMVMVS 192
PRK14151 PRK14151
heat shock protein GrpE; Provisional
 41-190 8.70e-36

heat shock protein GrpE; Provisional


Pssm-ID: 172640 [Multi-domain]  Cd Length: 176  Bit Score: 123.35  E-value: 8.70e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  41 EELKTRISELEGENVRLKNEYLKAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERALAIEpTPETES---YR 117
Cdd:PRK14151   23 DDLTARVQELEEQLAAAKDQSLRAAADLQNVRRRAEQDVEKAHKFALEKFAGDLLPVVDSLERGLELS-SADDEAikpMR 101

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2796385883 118 KGVEMIYQQLIHALTKEGVSEIEALGKEFDPNFHQALMMEAVEGAEPNHVVEVLQKGYLLKDRILRAAMVKVS 190
Cdd:PRK14151  102 EGVELTLKMFQDTLKRYQLEAVDPHGEPFNPEHHQAMAMQESADVEPNSVLKVFQKGYLLNGRLLRPAMVVVS 174
PRK14141 PRK14141
heat shock protein GrpE; Provisional
 50-190 4.86e-35

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 122.47  E-value: 4.86e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  50 LEGENVRLKNEYLKAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERAL-AI------EPTPETESYRKGVEM 122
Cdd:PRK14141   43 LKAENAELKDRMLRLAAEMENLRKRTQRDVADARAYGIAGFARDMLSVSDNLRRALdAIpaearaAADAGLKALIEGVEM 122

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2796385883 123 IYQQLIHALTKEGVSEIEALGKEFDPNFHQAlMMEAVEGAEPNH-VVEVLQKGYLLKDRILRAAMVKVS 190
Cdd:PRK14141  123 TERAMLNALERHGVKKLDPEGQKFDPNFHQA-MFEVPNPDVPNNtVVQVVQAGYTIGERVLRPAMVGVA 190
PRK14147 PRK14147
heat shock protein GrpE; Provisional
 39-191 2.85e-33

heat shock protein GrpE; Provisional


Pssm-ID: 237625 [Multi-domain]  Cd Length: 172  Bit Score: 116.59  E-value: 2.85e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  39 EIEELKTRISELEGENVRLKNEYLKAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERALAI---EPTPetes 115
Cdd:PRK14147   19 ETDPLKAEVESLRSEIALVKADALRERADLENQRKRIARDVEQARKFANEKLLGELLPVFDSLDAGLTAagtEPSP---- 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2796385883 116 YRKGVEMIYQQLIHALTKEGVSEIEALGKEFDPNFHQALMMEAVEGAEPNHVVEVLQKGYLLKDRILRAAMVKVSE 191
Cdd:PRK14147   95 LRDGLELTYKQLLKVAADNGLTLLDPVGQPFNPEHHQAISQGEAEGVAPGHVVQVFQKGYLLNERLLRPALVVVAK 170
PRK14155 PRK14155
heat shock protein GrpE; Provisional
 39-190 1.25e-32

heat shock protein GrpE; Provisional


Pssm-ID: 237627 [Multi-domain]  Cd Length: 208  Bit Score: 116.22  E-value: 1.25e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  39 EIEELKTRISELEGENVRLKNEYLKAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERALAIEPTPETESYRK 118
Cdd:PRK14155   14 EADDAAQEIEALKAEVAALKDQALRYAAEAENTKRRAEREMNDARAYAIQKFARDLLGAADNLGRATAASPKDSADPAVK 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2796385883 119 ----GVEMIYQQLIHALTKEGVSEIE-ALGKEFDPNFHQALMMEAVEGAEPNHVVEVLQKGYLLKDRILRAAMVKVS 190
Cdd:PRK14155   94 nfiiGVEMTEKELLGAFERNGLKKIDpAKGDKFDPHLHQAMMEQPSTEVAAGGVLQVMQAGYELMGRLVRPAMVAVA 170
PRK14143 PRK14143
heat shock protein GrpE; Provisional
 41-190 1.35e-32

heat shock protein GrpE; Provisional


Pssm-ID: 237624 [Multi-domain]  Cd Length: 238  Bit Score: 116.75  E-value: 1.35e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  41 EELKTRISELEGENVRLKNEYLKAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERALA-IEP-TPETESYRK 118
Cdd:PRK14143   70 AQLEQELESLKQELEELNSQYMRIAADFDNFRKRTSREQEDLRLQLKCNTLSEILPVVDNFERARQqLKPeGEEAQALHR 149

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2796385883 119 GVEMIYQQLIHALTKEGVSEIEALGKEFDPNFHQALMMEAVEGAEPNHVVEVLQKGYLLKDRILRAAMVKVS 190
Cdd:PRK14143  150 SYQGLYKQLVDVLKRLGVSPMRVVGQEFDPNLHEAVLREPSDEHPEDVVLEELQRGYHLGGRVLRHAMVKVS 221
PRK14145 PRK14145
heat shock protein GrpE; Provisional
 38-191 4.08e-32

heat shock protein GrpE; Provisional


Pssm-ID: 184536 [Multi-domain]  Cd Length: 196  Bit Score: 114.63  E-value: 4.08e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  38 NEIEELKTRISELEGEnvrlKNEYL----KAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERALAIEPtpET 113
Cdd:PRK14145   45 DEIEELKQKLQQKEVE----AQEYLdiaqRLKAEFENYRKRTEKEKSEMVEYGKEQVILELLPVMDNFERALASSG--DY 118

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2796385883 114 ESYRKGVEMIYQQLIHALTKEGVSEIEALGKEFDPNFHQALMMEAVEGAEPNHVVEVLQKGYLLKDRILRAAMVKVSE 191
Cdd:PRK14145  119 NSLKEGIELIYRQFKKILDKFGVKEIEAEGQIFDPYKHHAVMQEEVEGKQPNEIIEVFQKGYYLKDKVIRPSLVKVAK 196
PRK14156 PRK14156
heat shock protein GrpE; Provisional
 39-191 6.67e-32

heat shock protein GrpE; Provisional


Pssm-ID: 237628 [Multi-domain]  Cd Length: 177  Bit Score: 113.39  E-value: 6.67e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  39 EIEELKTRISELEGENVR---LKNEYLKAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERALAIEPTpeTES 115
Cdd:PRK14156   25 EVVEETPEKSELELANERadeFENKYLRAHAEMQNIQRRANEERQQLQRYRSQDLAKAILPSLDNLERALAVEGL--TDD 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2796385883 116 YRKGVEMIYQQLIHALTKEGVSEIEAlgKEFDPNFHQALM-MEAVEGAEPNHVVEVLQKGYLLKDRILRAAMVKVSE 191
Cdd:PRK14156  103 VKKGLEMVQESLIQALKEEGVEEVAV--DSFDHNLHMAVQtLPADDEHPADSIAQVFQKGYKLHERLLRPAMVVVYN 177
PRK14158 PRK14158
heat shock protein GrpE; Provisional
 35-190 2.47e-31

heat shock protein GrpE; Provisional


Pssm-ID: 172646 [Multi-domain]  Cd Length: 194  Bit Score: 112.33  E-value: 2.47e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  35 SKKNEIEELKTRISELEGENVRLKNEYLKAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERALAIEPTPETE 114
Cdd:PRK14158   37 AAADRIKELEEALAAKEAEAAANWDKYLRERADLENYRKRVQKEKEELLKYGNESLILEILPAVDNMERALDHADEESMS 116

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2796385883 115 SYRKGVEMIYQQLIHALTKEGVSEIEA-LGKEFDPNFHQALMMEAVEGAEPNHVVEVLQKGYLLKDRILRAAMVKVS 190
Cdd:PRK14158  117 AIIEGIRMTLSMLLSTLKKFGVTPVEAeKGTPFDPAYHQAMCQVESAEQEPNTVVAVFQKGYLLNERLLRPAMVSVA 193
PRK14160 PRK14160
heat shock protein GrpE; Provisional
 35-190 9.05e-30

heat shock protein GrpE; Provisional


Pssm-ID: 237629 [Multi-domain]  Cd Length: 211  Bit Score: 108.69  E-value: 9.05e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  35 SKKNEIEELKTRISELEGENVRLKNEY-------LKAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERALAI 107
Cdd:PRK14160   51 SNEVKIEELKDENNKLKEENKKLENELealkdrlLRTVAEYDNYRKRTAKEKEGIYSDACEDVLKELLPVLDNLERAAAV 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883 108 EPTpeTESYRKGVEMIYQQLIHALTKEGVSEIEALGkEFDPNFHQALMMEAVEGAEPNHVVEVLQKGYLLKDRILRAAMV 187
Cdd:PRK14160  131 EGS--VEDLKKGIEMTVKQFKTSLEKLGVEEISTEG-EFDPNLHNAVMHVEDENYGENEIVEVFQKGYKRGDKVIRYSMV 207


                  ...
gi 2796385883 188 KVS 190
Cdd:PRK14160  208 KVA 210
PRK14149 PRK14149
heat shock protein GrpE; Provisional
 36-189 6.71e-29

heat shock protein GrpE; Provisional


Pssm-ID: 184538 [Multi-domain]  Cd Length: 191  Bit Score: 106.11  E-value: 6.71e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  36 KKNEIEElktrisELEGENVRLKNEYLKAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERAL-AIEPTPETE 114
Cdd:PRK14149   40 KEGEIKE------DFELKYKEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGALkSAAEVDKES 113

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2796385883 115 SYRKGVEMIYQQLIHALTKEGVSEIEALGkEFDPNFHQALMMEAVEGAEPNHVVEVLQKGYLLKDRILRAAMVKV 189
Cdd:PRK14149  114 ALTKGLELTMEKLHEVLARHGIEGIECLE-EFDPNFHNAIMQVKSEEKENGKIVQVLQQGYKYKGRVLRPAMVSI 187
PRK14144 PRK14144
heat shock protein GrpE; Provisional
 62-190 9.00e-29

heat shock protein GrpE; Provisional


Pssm-ID: 184535 [Multi-domain]  Cd Length: 199  Bit Score: 105.96  E-value: 9.00e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  62 LKAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERALAIEPTPETESYRKGVEMIYQQLIHALTKEGVSEIEA 141
Cdd:PRK14144   69 VRALAELENVRRRMEREVANAHKYGVEKLISALLPVVDSLEQALQLADKNSDPSMHEGLELTMKLFLDALQKFDVEQIDP 148

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2796385883 142 LGKEFDPNFHQALMMEAVEGAEPNHVVEVLQKGYLLKDRILRAAMVKVS 190
Cdd:PRK14144  149 LGQTFDPQQHEAMSMQPAPGAPPNSVITVFQKGYKLSDRVIRPARVIVS 197
PRK14148 PRK14148
heat shock protein GrpE; Provisional
 34-189 4.25e-27

heat shock protein GrpE; Provisional


Pssm-ID: 172637 [Multi-domain]  Cd Length: 195  Bit Score: 101.37  E-value: 4.25e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  34 FSKKNEIEELKTRISELEGENVRLKNEYLKAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERALAIE-PTPE 112
Cdd:PRK14148   36 LSVEEQLERAKDTIKELEDSCDQFKDEALRAKAEMENIRKRAERDVSNARKFGIEKFAKELLPVIDSIEQALKHEvKLEE 115

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2796385883 113 TESYRKGVEMIYQQLIHALTKEGVSEIEALGKEFDPNFHQALMMEAVEGAEPNHVVEVLQKGYLLKDRILRAAMVKV 189
Cdd:PRK14148  116 AIAMKEGIELTAKMLVDILKKNGVEELDPKGEKFDPNLHEAMAMIPNPEFEDNTIFDVFQKGYMLNGRIVRAAKVVI 192
PRK14153 PRK14153
heat shock protein GrpE; Provisional
 47-190 7.25e-27

heat shock protein GrpE; Provisional


Pssm-ID: 184540 [Multi-domain]  Cd Length: 194  Bit Score: 100.69  E-value: 7.25e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  47 ISELEGENVRLKNEYLKAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERAL-AIEPTPETESYRKGVEMIYQ 125
Cdd:PRK14153   42 TEKCREEIESLKEQLFRLAAEFDNFRKRTAREMEENRKFVLEQVLLDLLEVTDNFERALeSARTAEDMNSIVEGIEMVSK 121

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2796385883 126 QLIHALTKEGVSEIEALGKEFDPNFHQALM-MEAVEGAEpNHVVEVLQKGYLLKDRILRAAMVKVS 190
Cdd:PRK14153  122 QFFSILEKYGLERIECEGEEFDPHRHEAMMhVETSEVPD-NTIVDVCKPGYALNSKVIRPAMVSVA 186
PRK10325 PRK10325
heat shock protein GrpE; Provisional
 41-191 3.55e-26

heat shock protein GrpE; Provisional


Pssm-ID: 182379 [Multi-domain]  Cd Length: 197  Bit Score: 99.36  E-value: 3.55e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  41 EELKTRISELEGENVRLKNEYLKAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERALAI--EPTPETESYRK 118
Cdd:PRK10325   42 EKIANLEAQLAEAQTRERDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVadKANPDMSAMVE 121

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2796385883 119 GVEMIYQQLIHALTKEGVSEIEALGKEFDPNFHQALMMEAVEGAEPNHVVEVLQKGYLLKDRILRAAMVKVSE 191
Cdd:PRK10325  122 GIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAK 194
PRK14159 PRK14159
heat shock protein GrpE; Provisional
 36-191 3.69e-25

heat shock protein GrpE; Provisional


Pssm-ID: 172647 [Multi-domain]  Cd Length: 176  Bit Score: 95.91  E-value: 3.69e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  36 KKNEIEELKTRISELegenvrlKNEYLKAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERALAIEPTPETE- 114
Cdd:PRK14159   28 EDVEQNKLQKDYDEL-------KDKYMRANAEFENIKKRMEKEKLSAMAYANESFAKDLLDVLDALEAAVNVECHDEISl 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2796385883 115 SYRKGVEMIYQQLIHALTKEGVSEIEAlGKEFDPNFHQALMMEAVEGAEPNHVVEVLQKGYLLKDRILRAAMVKVSE 191
Cdd:PRK14159  101 KIKEGVQNTLDLFLKKLEKHGVALIKE-EKEFDPNLHEAMFHVDSENHQSGEVVQVLQKGYKIADRVIRPTKVSVAK 176
PRK14154 PRK14154
heat shock protein GrpE; Provisional
 41-190 2.39e-23

heat shock protein GrpE; Provisional


Pssm-ID: 237626 [Multi-domain]  Cd Length: 208  Bit Score: 92.18  E-value: 2.39e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  41 EELKTRISELEGENVRLKNEYLKAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERALAIEPT--PETESYRK 118
Cdd:PRK14154   55 EKLEGQLTRMERKVDEYKTQYLRAQAEMDNLRKRIEREKADIIKFGSKQLITDLLPVADSLIHGLESPASedPQVKSMRD 134

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2796385883 119 GVEMIYQQLIHALTKEGVSEIEA-LGKEFDPNFHQALMMEAVEGAEPNHVVEVLQKGYLLKDRILRAAMVKVS 190
Cdd:PRK14154  135 GMSLTLDLLHNTLAKHGVQVINPnPGDPFDPALHEAMSVQAVPDAKPDTIIQVLQKGYQLNGRVLRAARVIVA 207
PRK14161 PRK14161
heat shock protein GrpE; Provisional
 39-191 1.82e-22

heat shock protein GrpE; Provisional


Pssm-ID: 237630 [Multi-domain]  Cd Length: 178  Bit Score: 88.88  E-value: 1.82e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  39 EIEELKTRISELegenvrlKNEYLKAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERALAIEPTP---ETES 115
Cdd:PRK14161   27 EITALKAEIEEL-------KDKLIRTTAEIDNTRKRLEKARDEAKDYAIATFAKELLNVSDNLSRALAHKPANsdvEVTN 99

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2796385883 116 YRKGVEMIYQQLIHALTKEGVSEIE-ALGKEFDPNFHQALMMEAVEGAEPNHVVEVLQKGYLLKDRILRAAMVKVSE 191
Cdd:PRK14161  100 IIAGVQMTKDELDKVFHKHHIEEIKpEIGSMFDYNLHNAISQIEHPDHAPNSIITLMQSGYKIRDRLLRPATVQVVK 176
PRK14146 PRK14146
heat shock protein GrpE; Provisional
 43-189 5.68e-17

heat shock protein GrpE; Provisional


Pssm-ID: 172635 [Multi-domain]  Cd Length: 215  Bit Score: 75.54  E-value: 5.68e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  43 LKTRISELEGENVRLKNEYLKAYADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERALAIE-PTPETESYRKGVE 121
Cdd:PRK14146   59 LQKELDNAKKEIESLKDSWARERAEFQNFKRRSAQEFVSIRKEAVKSLVSGFLNPIDNLERVGATQnQSEELKPFVEGVK 138

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2796385883 122 MIYQQLIHALTKEGVSEIEALGKEFDPNFHQALMMEAVEGAEPNHVVEVLQKGYLLKD----RILRAAMVKV 189
Cdd:PRK14146  139 MILKEFYSVLEKSNVIRFDPKGEPFDPMSMEALSSEEGDQYSEETVIDVYQAGYYYKEnedkFTLRPARVRI 210
PRK14163 PRK14163
heat shock protein GrpE; Provisional
 39-191 3.15e-14

heat shock protein GrpE; Provisional


Pssm-ID: 184546 [Multi-domain]  Cd Length: 214  Bit Score: 68.23  E-value: 3.15e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  39 EIEELKTRISELEGENVRLKNEYlkayadtENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERAlaieptPETESYRK 118
Cdd:PRK14163   48 QLDQVRTALGERTADLQRLQAEY-------QNYRRRVERDRVTVKEIAVANLLSELLPVLDDVGRA------REHGELVG 114

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2796385883 119 GVEMIYQQLIHALTKEGVSEIEALGKEFDPNFHQALMMEAVEGAEPNHVVEVLQKGYLLKDRILRAAMVKVSE 191
Cdd:PRK14163  115 GFKSVAESLETTVAKLGLQQFGKEGEPFDPTIHEALMHSYAPDVTETTCVAILQPGYRIGERTIRPARVAVAE 187
PRK14157 PRK14157
heat shock protein GrpE; Provisional
 60-190 3.24e-11

heat shock protein GrpE; Provisional


Pssm-ID: 184543 [Multi-domain]  Cd Length: 227  Bit Score: 59.97  E-value: 3.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  60 EYLKAY----ADTENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLERalaIEPTPETESYRKGVEmiyQQLIHALTKEG 135
Cdd:PRK14157   95 EYLEALqrerAEFINYRNRTQKEQDRFRQHGIIDVLTALLPALDDIDR---IREHSEMDDSFKAVA---AKIDKAFEKFG 168

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2796385883 136 VSEIEALGKEFDPNFHQALMMEAVEGAEPNHVVEVLQKGYLLKDRILRAAMVKVS 190
Cdd:PRK14157  169 VEKFGEKGEDFDPTKHDAILHKPDPDAEKETVDTVVEAGYRIGDRVIRAARVVVA 223
PRK14142 PRK14142
heat shock protein GrpE; Provisional
 66-189 6.59e-10

heat shock protein GrpE; Provisional


Pssm-ID: 237623  Cd Length: 223  Bit Score: 56.16  E-value: 6.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  66 ADTENTRRRL---QQEAEQTRKYRIQSfalDILPVLDNLERALA---IEPTPetesyrkgVEMIYQQLIHALTKEGVSEI 139
Cdd:PRK14142   61 ADFANYRKRAlrdQQAAADRAKASVVS---QLLGVLDDLERARKhgdLESGP--------LKSVADKLDSALTGLGLVAF 129

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2796385883 140 EALGKEFDPNFHQALMMEAVEGAEPNHVV-EVLQKGYLLKDRILRAAMVKV 189
Cdd:PRK14142  130 GAEGEDFDPVLHEAVQHEGDGGQGSKPVIgTVMRQGYQLGEQVLRHALVGV 180
PRK14164 PRK14164
heat shock protein GrpE; Provisional
 41-187 1.01e-09

heat shock protein GrpE; Provisional


Pssm-ID: 237632 [Multi-domain]  Cd Length: 218  Bit Score: 55.58  E-value: 1.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796385883  41 EELKTRISELEgenvRLKNEYlkayadtENTRRRLQQEAEQTRKYRIQSFALDILPVLDNLEraLAIEPTPETESYRKGv 120
Cdd:PRK14164   84 AQLAERTEDLQ----RVTAEY-------ANYRRRTERERQAIIETAKAGVATDLLPILDDLD--LAEQHGDLNEGPLKA- 149

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2796385883 121 emIYQQLIHALTKEGVSEIEALGKEFDPNFHQALMmEAVEGAEpNHVVEVLQKGYLLKDRILRAAMV 187
Cdd:PRK14164  150 --FSDKLTNVLAGLKVEKFGEEGDAFDPEIHEAVQ-DLSSGDE-KVLGTVLRKGYRMGDRVLRTAMV 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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