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Conserved domains on  [gi|2796504284|ref|WP_373199112|]
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ATP-binding protein [Collinsella aerofaciens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 117-212 1.03e-13

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


:

Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 67.29  E-value: 1.03e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284  117 VIREIVENFIHAHFAEPIISI---LDGGD-TIRFADQGPGI--DDKERAFDFGVTSANSkmKRYIRGTGAGFPMVQEYLE 190
Cdd:smart00387   9 VLSNLLDNAIKYTPEGGRITVtleRDGDHvEITVEDNGPGIppEDLEKIFEPFFRTDKR--SRKIGGTGLGLSIVKKLVE 86

                           90       100
                   ....*....|....*....|..
gi 2796504284  191 NAGGAVSIEDNMGNGTVVTVSL 212
Cdd:smart00387  87 LHGGEISVESEPGGGTTFTITL 108
PABP-1234 super family cl31127
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 151-327 9.65e-07

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


The actual alignment was detected with superfamily member TIGR01628:

Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 51.35  E-value: 9.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284 151 PGIDD---KERAFDFG-VTSANSKMKRYIRGTGAGFPMVQEYlENAGGAVS-IEDNMGNGTVVTVSLNPKRVQEIERAGG 225
Cdd:TIGR01628 295 DTVTDeklRELFSECGeITSAKVMLDEKGVSRGFGFVCFSNP-EEANRAVTeMHGRMLGGKPLYVALAQRKEQRRAHLQD 373

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284 226 RGAAVRPETEQPTY--PLPGAFAQQPMAT----QQMQP-PVGQMQQPGMLPTQEPQAASmsmTPNMPEAMPLADQDAAAM 298
Cdd:TIGR01628 374 QFMQLQPRMRQLPMgsPMGGAMGQPPYYGqgpqQQFNGqPLGWPRMSMMPTPMGPGGPL---RPNGLAPMNAVRAPSRNA 450

                         170       180
                  ....*....|....*....|....*....
gi 2796504284 299 QQATGAPGGQQMGYQPYQRGYPYQQMSPL 327
Cdd:TIGR01628 451 QNAAQKPPMQPVMYPPNYQSLPLSQDLPQ 479
COG4742 super family cl34811
Predicted transcriptional regulator, contains HTH domain [Transcription];
427-472 4.16e-04

Predicted transcriptional regulator, contains HTH domain [Transcription];


The actual alignment was detected with superfamily member COG4742:

Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 42.19  E-value: 4.16e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2796504284 427 TDLARAFGNSAPTWSRTLNDLAQAGLVIKHGQKYHLTELGAARVRA 472
Cdd:COG4742    33 SELAESLDVSRSTILRQLKELEERGLIERDDGEYELTTLGRLVVEE 78
 
Name Accession Description Interval E-value
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 117-212 1.03e-13

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 67.29  E-value: 1.03e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284  117 VIREIVENFIHAHFAEPIISI---LDGGD-TIRFADQGPGI--DDKERAFDFGVTSANSkmKRYIRGTGAGFPMVQEYLE 190
Cdd:smart00387   9 VLSNLLDNAIKYTPEGGRITVtleRDGDHvEITVEDNGPGIppEDLEKIFEPFFRTDKR--SRKIGGTGLGLSIVKKLVE 86

                           90       100
                   ....*....|....*....|..
gi 2796504284  191 NAGGAVSIEDNMGNGTVVTVSL 212
Cdd:smart00387  87 LHGGEISVESEPGGGTTFTITL 108
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 117-212 1.10e-11

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 61.23  E-value: 1.10e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284 117 VIREIVEN-FIHAHFAEPI-ISILDGGD-TIRFADQGPGIDDKERAFDFGVTSanSKMKRYIRGTGAGFPMVQEYLENAG 193
Cdd:pfam02518   9 VLSNLLDNaLKHAAKAGEItVTLSEGGElTLTVEDNGIGIPPEDLPRIFEPFS--TADKRGGGGTGLGLSIVRKLVELLG 86

                          90
                  ....*....|....*....
gi 2796504284 194 GAVSIEDNMGNGTVVTVSL 212
Cdd:pfam02518  87 GTITVESEPGGGTTVTLTL 105
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
75-212 2.09e-11

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 64.93  E-value: 2.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284  75 DDML------STPRVIVIDPQDVRTYLEETTNTVYQCMKEQGGHISLMV-------------IREIVENFIH--AHFAEP 133
Cdd:COG0642   162 NDLLdlsrleAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLpddlptvrgdpdrLRQVLLNLLSnaIKYTPE 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284 134 ----IISILDGGDTIRF--ADQGPGI--DDKERAFDFGVTSANSkmkRYIRGTGAGFPMVQEYLENAGGAVSIEDNMGNG 205
Cdd:COG0642   242 ggtvTVSVRREGDRVRIsvEDTGPGIppEDLERIFEPFFRTDPS---RRGGGTGLGLAIVKRIVELHGGTIEVESEPGKG 318


                  ....*..
gi 2796504284 206 TVVTVSL 212
Cdd:COG0642   319 TTFTVTL 325
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 139-212 7.24e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 53.06  E-value: 7.24e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2796504284 139 DGGD-TIRFADQGPGI--DDKERAFDFGVTSANSKmkryirGTGAGFPMVQEYLENAGGAVSIEDNMGNGTVVTVSL 212
Cdd:cd16915    33 EGDDlVIEVRDTGPGIapELRDKVFERGVSTKGQG------ERGIGLALVRQSVERLGGSITVESEPGGGTTFSIRI 103
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 151-327 9.65e-07

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 51.35  E-value: 9.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284 151 PGIDD---KERAFDFG-VTSANSKMKRYIRGTGAGFPMVQEYlENAGGAVS-IEDNMGNGTVVTVSLNPKRVQEIERAGG 225
Cdd:TIGR01628 295 DTVTDeklRELFSECGeITSAKVMLDEKGVSRGFGFVCFSNP-EEANRAVTeMHGRMLGGKPLYVALAQRKEQRRAHLQD 373

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284 226 RGAAVRPETEQPTY--PLPGAFAQQPMAT----QQMQP-PVGQMQQPGMLPTQEPQAASmsmTPNMPEAMPLADQDAAAM 298
Cdd:TIGR01628 374 QFMQLQPRMRQLPMgsPMGGAMGQPPYYGqgpqQQFNGqPLGWPRMSMMPTPMGPGGPL---RPNGLAPMNAVRAPSRNA 450

                         170       180
                  ....*....|....*....|....*....
gi 2796504284 299 QQATGAPGGQQMGYQPYQRGYPYQQMSPL 327
Cdd:TIGR01628 451 QNAAQKPPMQPVMYPPNYQSLPLSQDLPQ 479
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
427-472 4.16e-04

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 42.19  E-value: 4.16e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2796504284 427 TDLARAFGNSAPTWSRTLNDLAQAGLVIKHGQKYHLTELGAARVRA 472
Cdd:COG4742    33 SELAESLDVSRSTILRQLKELEERGLIERDDGEYELTTLGRLVVEE 78
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 217-420 4.60e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 42.72  E-value: 4.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284 217 VQEIEraggrgAAVRPETEQPTYPLPGAFAQQPMATQQMQPPVGQMQQPGMLPTQEPQAASMSMTPNMPEAMPLAD---Q 293
Cdd:pfam09770 196 LEEVE------AAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTIlqrP 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284 294 DAAAMQQATGAPGGQQmgyQPYQRGYPYQQMSPLGYGQQFPqqyqqgyqqpyqqmpqqqynpwAQQMPLQPYQQWPQSFQ 373
Cdd:pfam09770 270 QSPQPDPAQPSIQPQA---QQFHQQPPPVPVQPTQILQNPN----------------------RLSAARVGYPQNPQPGV 324

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2796504284 374 QQMPPMQSSQQPAAQmmyPNAANQYAQPQPDVFVSDRGNAAlgYLAQ 420
Cdd:pfam09770 325 QPAPAHQAHRQQGSF---GRQAPIITHPQQLAQLSEEEKAA--YLDE 366
HTH_ICLR smart00346
helix_turn_helix isocitrate lyase regulation;
409-468 8.56e-04

helix_turn_helix isocitrate lyase regulation;


Pssm-ID: 214629 [Multi-domain]  Cd Length: 91  Bit Score: 38.33  E-value: 8.56e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2796504284  409 DRGNAALGYLA-QNQACGATDLARAFGNSAPTWSRTLNDLAQAGLVIKHGQ--KYHLT----ELGAA 468
Cdd:smart00346   5 ERGLAVLRALAeEPGGLTLAELAERLGLSKSTAHRLLNTLQELGYVEQDGQngRYRLGpkvlELGQS 71
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
 139-215 1.02e-03

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 41.36  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284 139 DGGD--TIRFADQGPGIDD--KERAFDFGVTSANSKMKRYirgtGAGFPMVQEYLENAGGAVSIEDNMGNGTVVTVSLnP 214
Cdd:PRK15053  464 DEGDdvVIEVADQGCGVPEslRDKIFEQGVSTRADEPGEH----GIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFI-P 538


                  .
gi 2796504284 215 K 215
Cdd:PRK15053  539 K 539
PRK11050 PRK11050
manganese-binding transcriptional regulator MntR;
418-472 2.20e-03

manganese-binding transcriptional regulator MntR;


Pssm-ID: 182927 [Multi-domain]  Cd Length: 152  Bit Score: 38.45  E-value: 2.20e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2796504284 418 LAQNQACGATDLARAFGNSAPTWSRTLNDLAQAGLVIKhgQKYH---LTELG---AARVRA 472
Cdd:PRK11050   46 IAEVGEARQVDIAARLGVSQPTVAKMLKRLARDGLVEM--RPYRgvfLTPEGeklAQESRE 104
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 415-474 3.71e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 36.12  E-value: 3.71e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2796504284 415 LGYLAQNQACgATDLARAFGNSAPTWSRTLNDLAQAGLVIKHGQK----YHLTELGAARVRAQS 474
Cdd:cd00090    13 LRLLLEGPLT-VSELAERLGLSQSTVSRHLKKLEEAGLVESRREGrrvyYSLTDAERLLALLES 75
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 413-455 4.99e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 35.26  E-value: 4.99e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2796504284 413 AALGYLAQNQACGATDLARAFGNSAPTWSRTLNDLAQAGLVIK 455
Cdd:pfam12802   9 RVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVER 51
 
Name Accession Description Interval E-value
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 117-212 1.03e-13

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 67.29  E-value: 1.03e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284  117 VIREIVENFIHAHFAEPIISI---LDGGD-TIRFADQGPGI--DDKERAFDFGVTSANSkmKRYIRGTGAGFPMVQEYLE 190
Cdd:smart00387   9 VLSNLLDNAIKYTPEGGRITVtleRDGDHvEITVEDNGPGIppEDLEKIFEPFFRTDKR--SRKIGGTGLGLSIVKKLVE 86

                           90       100
                   ....*....|....*....|..
gi 2796504284  191 NAGGAVSIEDNMGNGTVVTVSL 212
Cdd:smart00387  87 LHGGEISVESEPGGGTTFTITL 108
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 117-212 1.10e-11

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 61.23  E-value: 1.10e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284 117 VIREIVEN-FIHAHFAEPI-ISILDGGD-TIRFADQGPGIDDKERAFDFGVTSanSKMKRYIRGTGAGFPMVQEYLENAG 193
Cdd:pfam02518   9 VLSNLLDNaLKHAAKAGEItVTLSEGGElTLTVEDNGIGIPPEDLPRIFEPFS--TADKRGGGGTGLGLSIVRKLVELLG 86

                          90
                  ....*....|....*....
gi 2796504284 194 GAVSIEDNMGNGTVVTVSL 212
Cdd:pfam02518  87 GTITVESEPGGGTTVTLTL 105
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
75-212 2.09e-11

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 64.93  E-value: 2.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284  75 DDML------STPRVIVIDPQDVRTYLEETTNTVYQCMKEQGGHISLMV-------------IREIVENFIH--AHFAEP 133
Cdd:COG0642   162 NDLLdlsrleAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLpddlptvrgdpdrLRQVLLNLLSnaIKYTPE 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284 134 ----IISILDGGDTIRF--ADQGPGI--DDKERAFDFGVTSANSkmkRYIRGTGAGFPMVQEYLENAGGAVSIEDNMGNG 205
Cdd:COG0642   242 ggtvTVSVRREGDRVRIsvEDTGPGIppEDLERIFEPFFRTDPS---RRGGGTGLGLAIVKRIVELHGGTIEVESEPGKG 318


                  ....*..
gi 2796504284 206 TVVTVSL 212
Cdd:COG0642   319 TTFTVTL 325
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
84-212 2.61e-09

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 57.61  E-value: 2.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284  84 IVIDPQDVRTYLEETTNTVYQCMKEQGGHISLMV-------------IREIVENFIH--AHFAEP----IISILDGGDTI 144
Cdd:COG2205    86 LELEPVDLAELLEEAVEELRPLAEEKGIRLELDLppelplvyadpelLEQVLANLLDnaIKYSPPggtiTISARREGDGV 165

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2796504284 145 RF--ADQGPGI--DDKERAFDFGVTSANSkmkRYIRGTGAGFPMVQEYLENAGGAVSIEDNMGNGTVVTVSL 212
Cdd:COG2205   166 RIsvSDNGPGIpeEELERIFERFYRGDNS---RGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 117-218 4.40e-09

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 58.32  E-value: 4.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284 117 VIREIVENFIHA----HFAEPIISIL---DGGD-TIRFADQGPGIDD--KERAFDFGVTSANSKmkryirGTGAGFPMVQ 186
Cdd:COG3290   285 ILGNLLDNAIEAveklPEEERRVELSirdDGDElVIEVEDSGPGIPEelLEKIFERGFSTKLGE------GRGLGLALVK 358

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2796504284 187 EYLENAGGAVSIEDNMGNGTVVTVSLnPKRVQ 218
Cdd:COG3290   359 QIVEKYGGTIEVESEEGEGTVFTVRL-PKEGE 389
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 139-212 7.24e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 53.06  E-value: 7.24e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2796504284 139 DGGD-TIRFADQGPGI--DDKERAFDFGVTSANSKmkryirGTGAGFPMVQEYLENAGGAVSIEDNMGNGTVVTVSL 212
Cdd:cd16915    33 EGDDlVIEVRDTGPGIapELRDKVFERGVSTKGQG------ERGIGLALVRQSVERLGGSITVESEPGGGTTFSIRI 103
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 117-212 5.53e-08

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 54.97  E-value: 5.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284 117 VIREIVENFIHAHFAEPIISI----LDGGDTIRFADQGPGI--DDKERAFDFGVTSanskmKRyiRGTGAGFPMVQEYLE 190
Cdd:COG5000   321 VLINLLKNAIEAIEEGGEIEVstrrEDGRVRIEVSDNGPGIpeEVLERIFEPFFTT-----KP--KGTGLGLAIVKKIVE 393

                          90       100
                  ....*....|....*....|..
gi 2796504284 191 NAGGAVSIEDNMGNGTVVTVSL 212
Cdd:COG5000   394 EHGGTIELESRPGGGTTFTIRL 415
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 121-212 1.84e-07

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 52.88  E-value: 1.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284 121 IVENFIHA--HFAEPIISI---LDGGD-TIRFADQGPGIDD--KERAFD-FgVTSanskmKRYIRGTGAGFPMVQEYLEN 191
Cdd:COG4191   264 LLINAIDAmeEGEGGRITIstrREGDYvVISVRDNGPGIPPevLERIFEpF-FTT-----KPVGKGTGLGLSISYGIVEK 337

                          90       100
                  ....*....|....*....|.
gi 2796504284 192 AGGAVSIEDNMGNGTVVTVSL 212
Cdd:COG4191   338 HGGRIEVESEPGGGTTFTITL 358
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 113-212 5.48e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 48.17  E-value: 5.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284 113 ISLMViREIVENFIHAHFAEPIISIL---DGGDTIRFADQGPGIDDKERAFDFgvtsanskmKRYIR-------GTGAGF 182
Cdd:cd16940    14 LFLLL-RNLVDNAVRYSPQGSRVEIKlsaDDGAVIRVEDNGPGIDEEELEALF---------ERFYRsdgqnygGSGLGL 83

                          90       100       110
                  ....*....|....*....|....*....|
gi 2796504284 183 PMVQEYLENAGGAVSIEDNMGNGTVVTVSL 212
Cdd:cd16940    84 SIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 151-327 9.65e-07

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 51.35  E-value: 9.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284 151 PGIDD---KERAFDFG-VTSANSKMKRYIRGTGAGFPMVQEYlENAGGAVS-IEDNMGNGTVVTVSLNPKRVQEIERAGG 225
Cdd:TIGR01628 295 DTVTDeklRELFSECGeITSAKVMLDEKGVSRGFGFVCFSNP-EEANRAVTeMHGRMLGGKPLYVALAQRKEQRRAHLQD 373

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284 226 RGAAVRPETEQPTY--PLPGAFAQQPMAT----QQMQP-PVGQMQQPGMLPTQEPQAASmsmTPNMPEAMPLADQDAAAM 298
Cdd:TIGR01628 374 QFMQLQPRMRQLPMgsPMGGAMGQPPYYGqgpqQQFNGqPLGWPRMSMMPTPMGPGGPL---RPNGLAPMNAVRAPSRNA 450

                         170       180
                  ....*....|....*....|....*....
gi 2796504284 299 QQATGAPGGQQMGYQPYQRGYPYQQMSPL 327
Cdd:TIGR01628 451 QNAAQKPPMQPVMYPPNYQSLPLSQDLPQ 479
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
75-212 1.65e-06

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 50.32  E-value: 1.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284  75 DDML------STPRVIVIDPQDVRTYLEETTNTVYQCMKEQGGHISL-------MV------IREIVENFIH--AHFAEP 133
Cdd:COG5002   220 NDLLdlsrleSGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELdlpedplLVlgdpdrLEQVLTNLLDnaIKYTPE 299

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284 134 ----IISILDGGDTIRFA--DQGPGI--DDKERAFD--FGVTSANSkmkRYIRGTGAGFPMVQEYLENAGGAVSIEDNMG 203
Cdd:COG5002   300 ggtiTVSLREEDDQVRISvrDTGIGIpeEDLPRIFErfYRVDKSRS---RETGGTGLGLAIVKHIVEAHGGRIWVESEPG 376


                  ....*....
gi 2796504284 204 NGTVVTVSL 212
Cdd:COG5002   377 KGTTFTITL 385
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
144-212 3.40e-06

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 49.07  E-value: 3.40e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2796504284 144 IRFADQGPGIDD--KERAFDFGVTSansKMKryirGTGAGFPMVQEYLENAGGAVSIEDNMGNGTVVTVSL 212
Cdd:COG3852   289 IEVIDNGPGIPEeiLDRIFEPFFTT---KEK----GTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYL 352
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 116-213 6.68e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 41.89  E-value: 6.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284 116 MVIREIVENFIHAHFAEPIISI----LDGGDTIRFADQGPGIDDKE--RAFDFGVTSANSKmkRYIRGTGAGFPMVQEYL 189
Cdd:cd16948     8 FIIGQIVSNALKYSKQGGKIEIysetNEQGVVLSIKDFGIGIPEEDlpRVFDKGFTGENGR--NFQESTGMGLYLVKKLC 85

                          90       100
                  ....*....|....*....|....
gi 2796504284 190 ENAGGAVSIEDNMGNGTVVTVSLN 213
Cdd:cd16948    86 DKLGHKIDVESEVGEGTTFTITFP 109
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
427-472 4.16e-04

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 42.19  E-value: 4.16e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2796504284 427 TDLARAFGNSAPTWSRTLNDLAQAGLVIKHGQKYHLTELGAARVRA 472
Cdd:COG4742    33 SELAESLDVSRSTILRQLKELEERGLIERDDGEYELTTLGRLVVEE 78
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 144-224 4.46e-04

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 42.65  E-value: 4.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284 144 IRFADQGPGIDDK--ERAFD-FGVTsansKMKryirGTGAGFPMVQEYLENAGGAVSIEDNMGNGTVVTVSLnPKRVQEI 220
Cdd:COG5809   415 ISVTDEGCGIPEErlKKLGEpFYTT----KEK----GTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITL-PIKLSEQ 485


                  ....
gi 2796504284 221 ERAG 224
Cdd:COG5809   486 VSMN 489
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 217-420 4.60e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 42.72  E-value: 4.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284 217 VQEIEraggrgAAVRPETEQPTYPLPGAFAQQPMATQQMQPPVGQMQQPGMLPTQEPQAASMSMTPNMPEAMPLAD---Q 293
Cdd:pfam09770 196 LEEVE------AAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTIlqrP 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284 294 DAAAMQQATGAPGGQQmgyQPYQRGYPYQQMSPLGYGQQFPqqyqqgyqqpyqqmpqqqynpwAQQMPLQPYQQWPQSFQ 373
Cdd:pfam09770 270 QSPQPDPAQPSIQPQA---QQFHQQPPPVPVQPTQILQNPN----------------------RLSAARVGYPQNPQPGV 324

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2796504284 374 QQMPPMQSSQQPAAQmmyPNAANQYAQPQPDVFVSDRGNAAlgYLAQ 420
Cdd:pfam09770 325 QPAPAHQAHRQQGSF---GRQAPIITHPQQLAQLSEEEKAA--YLDE 366
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
414-472 4.92e-04

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 40.34  E-value: 4.92e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2796504284 414 ALGYLAQNQACGATDLARAFGNSAPTWSRTLNDLAQAGLVIKH-------GQKYHLTELGAARVRA 472
Cdd:COG1846    43 VLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREpdpedrrAVLVRLTEKGRALLEE 108
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 69-213 5.61e-04

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 40.79  E-value: 5.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284  69 ARIAVYDDMLSTPRVIVIDPQDVRTYLEETtntvyqcmkeqggHISLMvIREIVENFIHA---------HFAEPIISILD 139
Cdd:cd16929    13 ARVLCDDYYLSSPELEIEGDPSIRFPYVPS-------------HLYYI-LFELLKNAMRAtveshgddsDDLPPIKVTVA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284 140 GGD---TIRFADQGPGI--DDKERAFDFGVTSANSKMKRYIR------------GTGAGFPMVQEYLENAGGAVSIEDNM 202
Cdd:cd16929    79 KGDedlTIKISDRGGGIprEDLARLFSYMYSTAPQPSLDDFSdlisgtqpsplaGFGYGLPMSRLYAEYFGGDLDLQSME 158

                         170
                  ....*....|.
gi 2796504284 203 GNGTVVTVSLN 213
Cdd:cd16929   159 GYGTDVYIYLK 169
HTH_ICLR smart00346
helix_turn_helix isocitrate lyase regulation;
409-468 8.56e-04

helix_turn_helix isocitrate lyase regulation;


Pssm-ID: 214629 [Multi-domain]  Cd Length: 91  Bit Score: 38.33  E-value: 8.56e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2796504284  409 DRGNAALGYLA-QNQACGATDLARAFGNSAPTWSRTLNDLAQAGLVIKHGQ--KYHLT----ELGAA 468
Cdd:smart00346   5 ERGLAVLRALAeEPGGLTLAELAERLGLSKSTAHRLLNTLQELGYVEQDGQngRYRLGpkvlELGQS 71
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
427-471 9.89e-04

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 39.42  E-value: 9.89e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2796504284 427 TDLARAFGNSAPTWSRTLNDLAQAGLVIK-HGQKYHLTELG---AARVR 471
Cdd:COG1321    28 SDIAERLGVSPPSVTEMLKKLEEKGLVEYePYGGITLTEEGrelALRIV 76
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
 139-215 1.02e-03

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 41.36  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284 139 DGGD--TIRFADQGPGIDD--KERAFDFGVTSANSKMKRYirgtGAGFPMVQEYLENAGGAVSIEDNMGNGTVVTVSLnP 214
Cdd:PRK15053  464 DEGDdvVIEVADQGCGVPEslRDKIFEQGVSTRADEPGEH----GIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFI-P 538


                  .
gi 2796504284 215 K 215
Cdd:PRK15053  539 K 539
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
417-473 1.34e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 37.19  E-value: 1.34e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2796504284  417 YLAQNQACgATDLARAFGNSAPTWSRTLNDLAQAGLV--IKHGQK--YHLTELGAARVRAQ 473
Cdd:smart00418   5 LLAEGELC-VCELAEILGLSQSTVSHHLKKLREAGLVesRREGKRvyYSLTDEKVADLLEE 64
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
144-224 1.50e-03

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 40.93  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284 144 IRFADQGPGI--DDKERAFDFGVTSANskmkryiRGTGAGFPMVQEYLENAGGAVSIEDNMGNGTVVTVSLnPKRVQEIE 221
Cdd:PRK10364  383 ISVTDSGKGIaaDQLEAIFTPYFTTKA-------EGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWL-PVNITRRD 454


                  ...
gi 2796504284 222 RAG 224
Cdd:PRK10364  455 PQG 457
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
148-237 1.87e-03

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 40.87  E-value: 1.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284  148 DQGPGIDDKERAFDFGVTSANSKmKRYIRGTGAGFPMVQEYLENAGGAVSIEDNMGNGTVVTVSLNPKRVQEIeraggrg 227
Cdd:PRK09959   871 DSGSGLSQEEQQQLFKRYSQTSA-GRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPVEISQQV------- 942

                           90
                   ....*....|
gi 2796504284  228 AAVRPETEQP 237
Cdd:PRK09959   943 ATVEAKAEQP 952
PRK11050 PRK11050
manganese-binding transcriptional regulator MntR;
418-472 2.20e-03

manganese-binding transcriptional regulator MntR;


Pssm-ID: 182927 [Multi-domain]  Cd Length: 152  Bit Score: 38.45  E-value: 2.20e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2796504284 418 LAQNQACGATDLARAFGNSAPTWSRTLNDLAQAGLVIKhgQKYH---LTELG---AARVRA 472
Cdd:PRK11050   46 IAEVGEARQVDIAARLGVSQPTVAKMLKRLARDGLVEM--RPYRgvfLTPEGeklAQESRE 104
HATPase_RsbT-like cd16934
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ...
 117-210 2.56e-03

Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.


Pssm-ID: 340411 [Multi-domain]  Cd Length: 117  Bit Score: 37.73  E-value: 2.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284 117 VIREIVENFI-HAHFAEPIISILDGGDT----IRFADQGPGIDDKERAFDFGVTSANskmkryirGTGAGFPMVQEylen 191
Cdd:cd16934    29 AVTELARNLLkHAGGGQVLLEVVAEGGRvaleILAVDQGPGIADVDEALRDGFSTGG--------GLGLGLGGVRR---- 96

                          90
                  ....*....|....*....
gi 2796504284 192 AGGAVSIEDNMGNGTVVTV 210
Cdd:cd16934    97 LADEFDLHSAPGRGTVVVA 115
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 143-212 2.56e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 37.31  E-value: 2.56e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2796504284 143 TIRFADQGPGIDDKE-----RAFdFGVTSANSKMKryiRGTGAGFPMVQEYLENAGGAVSIEDNMGNGTVVTVSL 212
Cdd:cd16949    32 TITITDDGPGVPEDQleqifLPF-YRVDSARDRES---GGTGLGLAIAERAIEQHGGKIKASNRKPGGLRVRIWL 102
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
409-468 2.85e-03

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 39.42  E-value: 2.85e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2796504284 409 DRGNAALGYLAQN-QACGATDLARAFGNSAPTWSRTLNDLAQAGLVIK--HGQKYHLT----ELGAA 468
Cdd:COG1414     9 ERALAILEALAEAgGGLSLSELARRLGLPKSTVHRLLATLEEEGYVERdpEGGRYRLGprllELGSA 75
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 415-474 3.71e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 36.12  E-value: 3.71e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2796504284 415 LGYLAQNQACgATDLARAFGNSAPTWSRTLNDLAQAGLVIKHGQK----YHLTELGAARVRAQS 474
Cdd:cd00090    13 LRLLLEGPLT-VSELAERLGLSQSTVSRHLKKLEEAGLVESRREGrrvyYSLTDAERLLALLES 75
HTH_CRP smart00419
helix_turn_helix, cAMP Regulatory protein;
428-463 3.79e-03

helix_turn_helix, cAMP Regulatory protein;


Pssm-ID: 128696 [Multi-domain]  Cd Length: 48  Bit Score: 35.49  E-value: 3.79e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2796504284  428 DLARAFGNSAPTWSRTLNDLAQAGLVIKHGQKYHLT 463
Cdd:smart00419  13 EIAELLGLTRETVSRTLKRLEKEGLISREGGRIVIL 48
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 135-215 3.96e-03

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 39.71  E-value: 3.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796504284 135 ISILDGGDT--IRFADQGPGIDdKERAFDFGVTSANSKMKryirGTGAGFPMVQEYLENAGGAVSIEDNMGNGTVVTVSL 212
Cdd:COG5805   419 IHTEEEDNSviIRVIDEGIGIP-EERLKKLGEPFFTTKEK----GTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITL 493


                  ...
gi 2796504284 213 nPK 215
Cdd:COG5805   494 -PL 495
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 413-455 4.99e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 35.26  E-value: 4.99e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2796504284 413 AALGYLAQNQACGATDLARAFGNSAPTWSRTLNDLAQAGLVIK 455
Cdd:pfam12802   9 RVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVER 51
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 147-212 7.14e-03

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 36.59  E-value: 7.14e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2796504284 147 ADQGPGIDD--KERAFD-FGVTsanskmKRYIRGTGAGFPMVQEYLENAGGAVSIEDNMGNGTVVTVSL 212
Cdd:cd16919    53 SDTGSGMPAevLRRAFEpFFTT------KEVGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYL 115
HTH_CRP cd00092
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
 410-460 9.25e-03

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


Pssm-ID: 238044 [Multi-domain]  Cd Length: 67  Bit Score: 34.95  E-value: 9.25e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2796504284 410 RGNAALGYLAQNQACGAT--------DLARAFGNSAPTWSRTLNDLAQAGLVIKHGQKY 460
Cdd:cd00092     4 RLASFLLNLSLRYGAGDLvqlpltrqEIADYLGLTRETVSRTLKELEEEGLISRRGRGK 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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