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Conserved domains on  [gi|2796900831|ref|WP_373287565|]
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MFS transporter [Streptomyces purpureus]

Protein Classification

MFS transporter( domain architecture ID 12947616)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 35-412 5.43e-41

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 149.69  E-value: 5.43e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831  35 TAVTSLADGVMKTTLPFLAAQLTDSPSQVTAVSLTLTLPWLLIALHIGVLVDRFDRRLLLWGANGMRLAAMGWLTASALG 114
Cdd:cd06173     8 QLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 115 GGVTLTHLFAAGAILGVADVLASTSAAALVPAAVPATARERANAWMLGAETVGFEFAGPFIGGLLLAAGAGLALGATSAS 194
Cdd:cd06173    88 GSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALS 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 195 YAVAALVLVLLVGRFQAArpvPGAAPASVGSRIAEGLRFIWQNRVLRTLMLVVSVLNATWGAWLALLPLYAKETLGLGPQ 274
Cdd:cd06173   168 FLLSALLLLFIRRPPPAA---PGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAA 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 275 EYGIALSALGIGGLTGALVVTRVNRLLGARGAMFADLIATITMVALPALTTSVWSIAVGAFLGGMGGTLWTVNSRTIAQR 354
Cdd:cd06173   245 GYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQL 324

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2796900831 355 LVPDEMLGRFNATFRFFAFGALPLGAGLVGLLAELADSRLAFGVFAVATTATVVPFLR 412
Cdd:cd06173   325 RVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
 
Name Accession Description Interval E-value
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 35-412 5.43e-41

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 149.69  E-value: 5.43e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831  35 TAVTSLADGVMKTTLPFLAAQLTDSPSQVTAVSLTLTLPWLLIALHIGVLVDRFDRRLLLWGANGMRLAAMGWLTASALG 114
Cdd:cd06173     8 QLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 115 GGVTLTHLFAAGAILGVADVLASTSAAALVPAAVPATARERANAWMLGAETVGFEFAGPFIGGLLLAAGAGLALGATSAS 194
Cdd:cd06173    88 GSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALS 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 195 YAVAALVLVLLVGRFQAArpvPGAAPASVGSRIAEGLRFIWQNRVLRTLMLVVSVLNATWGAWLALLPLYAKETLGLGPQ 274
Cdd:cd06173   168 FLLSALLLLFIRRPPPAA---PGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAA 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 275 EYGIALSALGIGGLTGALVVTRVNRLLGARGAMFADLIATITMVALPALTTSVWSIAVGAFLGGMGGTLWTVNSRTIAQR 354
Cdd:cd06173   245 GYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQL 324

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2796900831 355 LVPDEMLGRFNATFRFFAFGALPLGAGLVGLLAELADSRLAFGVFAVATTATVVPFLR 412
Cdd:cd06173   325 RVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
2A0121 TIGR00900
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
 31-388 1.87e-30

H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 162098 [Multi-domain]  Cd Length: 365  Bit Score: 120.50  E-value: 1.87e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831  31 LVGFTAVTSLADGVMKTTLPFLAAQLTDSPSQVTAVSLTLTLPWLLIALHIGVLVDRFDRRLLLWGANGMRLAAMGWLTA 110
Cdd:TIGR00900   4 LFAAQLISLIGTAITQVALPLYVLAGTGSASVLSLAALAGMLPYVVLSPIAGALADRYDRKKVMIGADLIRAVLVAVLPF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 111 SALGGGVTLTHLFAAGAILGVADVLASTSAAALVPAAVPATARERANAwMLGAETVGFEFAGPFIGGLLLAAGAGLALGA 190
Cdd:TIGR00900  84 VALLGGLNIWQVYVLAGILAIAQAFFTPAYQAMLPDLVPEEQLTQANS-LSQAVRSLFYIVGPGIGGLMYATLGIKWAIW 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 191 TSA-SYAVAALVLVLLVGRFQAARPVPGAAPASVgSRIAEGLRFIWQNRVLRTLMLVVSVLNATW-GAWLALLPLYAKET 268
Cdd:TIGR00900 163 VDAvGFAISALLIVSVRIPELAASEIQALSNAVL-RDTREGIKFVLKNPLLRTLLLLALLFNLVFaPAIVALFPYVQSKY 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 269 LGLGPQEYGIALSALGIGGLTGALVVTRVNRLLGARGAM-FADLIATITMVALPALTTSVWSIAVGAFLGGMGGTLWTVN 347
Cdd:TIGR00900 242 LGRGSTHYGWVLAAFGLGALLGALLLGLLGRYFKRMALMtGAIFVIGLAILVVGLTPPNFPLFLVLWFAIGVGYGPINVP 321

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 2796900831 348 SRTIAQRLVPDEMLGRFNATFRFFAFGALPLGAGLVGLLAE 388
Cdd:TIGR00900 322 QGTLLQRRVPAELLGRVFGAQFSLSHAAWPLGLILAGPLAD 362
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
18-378 1.30e-18

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 86.57  E-value: 1.30e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831  18 APQAATGRRNTAVLVGFTAVTSLADGVMKTTLPFLAAQLTDSPSQVTAVSLTLTLPWLLIALHIGVLVDRFDRRLLLwga 97
Cdd:COG2814     2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVL--- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831  98 ngmrLAAMGWLTASALGGGV--TLTHLFAAGAILGVADVLASTSAAALVPAAVPATARERANAWMLGAETVGFeFAGPFI 175
Cdd:COG2814    79 ----LLGLLLFALGSLLCALapSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGP-ALGPLL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 176 GGLLLAAGAGLALGATSASYAVAALVLvllvgrfqAARPVPGAAPASvGSRIAEGLRFIWQNRVLRTLMLVVSVLNATWG 255
Cdd:COG2814   154 GGLLADLFGWRWVFLVNAVLALLALLL--------LLRLLPESRPAA-RARLRGSLRELLRRPRLLLLLLLAFLLGFGFF 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 256 AWLALLPLYAKETLGLGPQEYGIALSALGIGGLTGALVVTRVNRLLGARGAMFADLIATITMVALPALTTSVWSIAVGAF 335
Cdd:COG2814   225 ALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALF 304

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 2796900831 336 LGGMGGTLWTVNSRTIAQRLVPDEMLGRFNATFRFFAFGALPL 378
Cdd:COG2814   305 LLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_3 pfam05977
Transmembrane secretion effector; This is a family of transport proteins. Members of this ...
 51-412 1.39e-15

Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.


Pssm-ID: 399164 [Multi-domain]  Cd Length: 523  Bit Score: 78.64  E-value: 1.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831  51 FLAAQLTDSPSQVTAVSLTLTLPWLLIALHIGVLVDRFDRRLLLWGANGMRLAAMGWLTASALGGGVTLTHLFAAGAILG 130
Cdd:pfam05977  35 WLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLALVSTLLTLLAGLGLLSPWLLLGLTFLGG 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 131 VADVLasTSAAALVPAAVPATARERANAWMLgaETVGFEFA---GPFIGGLLLAAGAGLALGATSASYAVAALVLVLLVG 207
Cdd:pfam05977 115 IGTAL--MDPAWQASVPELVPRRDLPAAVAL--NSVGYNIArsvGPALGGVLLAAFGPAFTFALNALSYFAVIAALWRWK 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 208 RFQAARPVPgaaPASVGSRIAEGLRFIWQNRVLRTLMLVVSVLNATWGAWLALLPLYAKETLGLGPQEYGIALSALGIGG 287
Cdd:pfam05977 191 RAAPASPLP---RERIFGAVRAGLRFTAMSRELRSVLVRAFAFGLSASAVWALLPLVARDLLDGDAIFYGILLGAVGVGA 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 288 LTGALVVTRVNRLLGARGAMFADLIATITMVALPALTTSVWSIAVGAFLGGMG--GTLWTVNsrTIAQRLVPDEMLGRFN 365
Cdd:pfam05977 268 ILGALSLPRLRERLGSDRLVLLASVVTALVLLSLALAPNLWLAIPVLLLGGAAwiTALTTLN--VAVQLSVPRWVRGRAL 345

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 2796900831 366 ATFRFFAFGALPLGAGLVGLLAELADSRLAFGVFAVATTATVVPFLR 412
Cdd:pfam05977 346 AVYQTVFFGGMAAGSWLWGAVAEALSVTGALLGAAAALLAGAAAGLR 392
PRK10489 PRK10489
enterobactin transporter EntS;
214-411 2.26e-09

enterobactin transporter EntS;


Pssm-ID: 236700 [Multi-domain]  Cd Length: 417  Bit Score: 58.84  E-value: 2.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 214 PVPGAAPASVGSRIAEGLRFIWQNRVLRTLMLVVSVLNATwGAWLALLPLYAKETLGLGPQEYGIALSALGIGGLTGALV 293
Cdd:PRK10489  200 PPPPQPREHPLRSLLAGFRFLLASPVVGGIALLGGLLTMA-SAVRVLYPALADEVWQMGAAQIGLLYAAVPLGAALGALT 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 294 VTRVNRLLGARGAMFADLIATITMVALPALTTSVWSIAVGAFLGGMGGTLWTVNSRTIAQRLVPDEMLGRFNATFRFFAF 373
Cdd:PRK10489  279 SGWLAHSARPGLLMLLSTLGSFLAVGLFGLMPMWILAVLCLALFGYLSAISSLLQYTLLQTQTPDEMLGRINGLWTAQNV 358

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2796900831 374 GALPLGAGLVGLLAELADSRLAFGVFAVATTATVVPFL 411
Cdd:PRK10489  359 TGDAIGAALLGGLGAMMTPVASASASGFGLLIIGVLLL 396
 
Name Accession Description Interval E-value
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 35-412 5.43e-41

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 149.69  E-value: 5.43e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831  35 TAVTSLADGVMKTTLPFLAAQLTDSPSQVTAVSLTLTLPWLLIALHIGVLVDRFDRRLLLWGANGMRLAAMGWLTASALG 114
Cdd:cd06173     8 QLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 115 GGVTLTHLFAAGAILGVADVLASTSAAALVPAAVPATARERANAWMLGAETVGFEFAGPFIGGLLLAAGAGLALGATSAS 194
Cdd:cd06173    88 GSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALS 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 195 YAVAALVLVLLVGRFQAArpvPGAAPASVGSRIAEGLRFIWQNRVLRTLMLVVSVLNATWGAWLALLPLYAKETLGLGPQ 274
Cdd:cd06173   168 FLLSALLLLFIRRPPPAA---PGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAA 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 275 EYGIALSALGIGGLTGALVVTRVNRLLGARGAMFADLIATITMVALPALTTSVWSIAVGAFLGGMGGTLWTVNSRTIAQR 354
Cdd:cd06173   245 GYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQL 324

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2796900831 355 LVPDEMLGRFNATFRFFAFGALPLGAGLVGLLAELADSRLAFGVFAVATTATVVPFLR 412
Cdd:cd06173   325 RVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
2A0121 TIGR00900
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
 31-388 1.87e-30

H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 162098 [Multi-domain]  Cd Length: 365  Bit Score: 120.50  E-value: 1.87e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831  31 LVGFTAVTSLADGVMKTTLPFLAAQLTDSPSQVTAVSLTLTLPWLLIALHIGVLVDRFDRRLLLWGANGMRLAAMGWLTA 110
Cdd:TIGR00900   4 LFAAQLISLIGTAITQVALPLYVLAGTGSASVLSLAALAGMLPYVVLSPIAGALADRYDRKKVMIGADLIRAVLVAVLPF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 111 SALGGGVTLTHLFAAGAILGVADVLASTSAAALVPAAVPATARERANAwMLGAETVGFEFAGPFIGGLLLAAGAGLALGA 190
Cdd:TIGR00900  84 VALLGGLNIWQVYVLAGILAIAQAFFTPAYQAMLPDLVPEEQLTQANS-LSQAVRSLFYIVGPGIGGLMYATLGIKWAIW 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 191 TSA-SYAVAALVLVLLVGRFQAARPVPGAAPASVgSRIAEGLRFIWQNRVLRTLMLVVSVLNATW-GAWLALLPLYAKET 268
Cdd:TIGR00900 163 VDAvGFAISALLIVSVRIPELAASEIQALSNAVL-RDTREGIKFVLKNPLLRTLLLLALLFNLVFaPAIVALFPYVQSKY 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 269 LGLGPQEYGIALSALGIGGLTGALVVTRVNRLLGARGAM-FADLIATITMVALPALTTSVWSIAVGAFLGGMGGTLWTVN 347
Cdd:TIGR00900 242 LGRGSTHYGWVLAAFGLGALLGALLLGLLGRYFKRMALMtGAIFVIGLAILVVGLTPPNFPLFLVLWFAIGVGYGPINVP 321

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 2796900831 348 SRTIAQRLVPDEMLGRFNATFRFFAFGALPLGAGLVGLLAE 388
Cdd:TIGR00900 322 QGTLLQRRVPAELLGRVFGAQFSLSHAAWPLGLILAGPLAD 362
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
18-378 1.30e-18

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 86.57  E-value: 1.30e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831  18 APQAATGRRNTAVLVGFTAVTSLADGVMKTTLPFLAAQLTDSPSQVTAVSLTLTLPWLLIALHIGVLVDRFDRRLLLwga 97
Cdd:COG2814     2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVL--- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831  98 ngmrLAAMGWLTASALGGGV--TLTHLFAAGAILGVADVLASTSAAALVPAAVPATARERANAWMLGAETVGFeFAGPFI 175
Cdd:COG2814    79 ----LLGLLLFALGSLLCALapSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGP-ALGPLL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 176 GGLLLAAGAGLALGATSASYAVAALVLvllvgrfqAARPVPGAAPASvGSRIAEGLRFIWQNRVLRTLMLVVSVLNATWG 255
Cdd:COG2814   154 GGLLADLFGWRWVFLVNAVLALLALLL--------LLRLLPESRPAA-RARLRGSLRELLRRPRLLLLLLLAFLLGFGFF 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 256 AWLALLPLYAKETLGLGPQEYGIALSALGIGGLTGALVVTRVNRLLGARGAMFADLIATITMVALPALTTSVWSIAVGAF 335
Cdd:COG2814   225 ALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALF 304

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 2796900831 336 LGGMGGTLWTVNSRTIAQRLVPDEMLGRFNATFRFFAFGALPL 378
Cdd:COG2814   305 LLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_3 pfam05977
Transmembrane secretion effector; This is a family of transport proteins. Members of this ...
 51-412 1.39e-15

Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.


Pssm-ID: 399164 [Multi-domain]  Cd Length: 523  Bit Score: 78.64  E-value: 1.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831  51 FLAAQLTDSPSQVTAVSLTLTLPWLLIALHIGVLVDRFDRRLLLWGANGMRLAAMGWLTASALGGGVTLTHLFAAGAILG 130
Cdd:pfam05977  35 WLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLALVSTLLTLLAGLGLLSPWLLLGLTFLGG 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 131 VADVLasTSAAALVPAAVPATARERANAWMLgaETVGFEFA---GPFIGGLLLAAGAGLALGATSASYAVAALVLVLLVG 207
Cdd:pfam05977 115 IGTAL--MDPAWQASVPELVPRRDLPAAVAL--NSVGYNIArsvGPALGGVLLAAFGPAFTFALNALSYFAVIAALWRWK 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 208 RFQAARPVPgaaPASVGSRIAEGLRFIWQNRVLRTLMLVVSVLNATWGAWLALLPLYAKETLGLGPQEYGIALSALGIGG 287
Cdd:pfam05977 191 RAAPASPLP---RERIFGAVRAGLRFTAMSRELRSVLVRAFAFGLSASAVWALLPLVARDLLDGDAIFYGILLGAVGVGA 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 288 LTGALVVTRVNRLLGARGAMFADLIATITMVALPALTTSVWSIAVGAFLGGMG--GTLWTVNsrTIAQRLVPDEMLGRFN 365
Cdd:pfam05977 268 ILGALSLPRLRERLGSDRLVLLASVVTALVLLSLALAPNLWLAIPVLLLGGAAwiTALTTLN--VAVQLSVPRWVRGRAL 345

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 2796900831 366 ATFRFFAFGALPLGAGLVGLLAELADSRLAFGVFAVATTATVVPFLR 412
Cdd:pfam05977 346 AVYQTVFFGGMAAGSWLWGAVAEALSVTGALLGAAAALLAGAAAGLR 392
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 37-412 3.44e-14

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 73.38  E-value: 3.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831  37 VTSLADGVMKTTLPFLAAQLTDSPSQVTAVSLTLTLPWLLIALHIGVLVDRFDRRLLLWGANGMRLAAMGwltasALGGG 116
Cdd:cd17325     7 LDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTL-----LFAFA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 117 VTLTHLFAAGAILGVADVLASTSAAALVPAAVPATARERANAWMLGAETVGFeFAGPFIGGLLLAAGAGLALGATSAsya 196
Cdd:cd17325    82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGF-LIGPLLGGLLADALGYRAPFLVCA--- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 197 VAALVLVLLVGRFQAARPVPGAAPASVGSRIAEGLRFIWQNRVLRTLMLVVSVLNATWGAWLALLPLYAKETLGLGPQEY 276
Cdd:cd17325   158 ALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQI 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 277 GIALSALGIGGLTGALVVTRVNRLLGARGAMFADLIATITMVALPALTTSVWSIAVGAFLGGMGGTLWTVNSRTIAQRLV 356
Cdd:cd17325   238 GLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIV 317

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2796900831 357 PDEMLGRFNATFRFFAFGALPLGAGLVGLLAELADSRLAFGVFAVATTATVVPFLR 412
Cdd:cd17325   318 PPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 31-402 4.72e-13

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 70.15  E-value: 4.72e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831  31 LVGFTAVTSLADGVMKTTLPFLAAQLTDSPSQVTAVSLTLTLPWLLIALHIGVLVDRFDRRLLLWGANGMRLAAmgwltA 110
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALG-----A 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 111 SALGGGVTLTHLFAAGAILGVADVLASTSAAALVPAAVPATARERANAWMLGAETVGFEFAGPFIGGLLLAAGAGLALGA 190
Cdd:cd06174    76 LLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVF 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 191 TSASYAVAALVLVLLVGRFQAARPVPGAAPASVGSRIAEGLRFIWQNRVLRTLMLVVSVLNATWGAWLALLPLYAKETLG 270
Cdd:cd06174   156 LIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGG 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 271 LGPQEYGIALSALGIGGLTGALVVTRV-NRLLGARGAMFADLIATITMVALPALTTSVWSIAVGAFLGGMGGTLWTVNSR 349
Cdd:cd06174   236 LSVAVAGLLLSLFGLAGALGSLLLGLLsDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSF 315

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2796900831 350 TIAQRLVPDEMLGRFNATFRFFAFGALPLGAGLVGLLAELADS-RLAFGVFAVA 402
Cdd:cd06174   316 ALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGlTGAFLVLAVL 369
PRK10489 PRK10489
enterobactin transporter EntS;
214-411 2.26e-09

enterobactin transporter EntS;


Pssm-ID: 236700 [Multi-domain]  Cd Length: 417  Bit Score: 58.84  E-value: 2.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 214 PVPGAAPASVGSRIAEGLRFIWQNRVLRTLMLVVSVLNATwGAWLALLPLYAKETLGLGPQEYGIALSALGIGGLTGALV 293
Cdd:PRK10489  200 PPPPQPREHPLRSLLAGFRFLLASPVVGGIALLGGLLTMA-SAVRVLYPALADEVWQMGAAQIGLLYAAVPLGAALGALT 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 294 VTRVNRLLGARGAMFADLIATITMVALPALTTSVWSIAVGAFLGGMGGTLWTVNSRTIAQRLVPDEMLGRFNATFRFFAF 373
Cdd:PRK10489  279 SGWLAHSARPGLLMLLSTLGSFLAVGLFGLMPMWILAVLCLALFGYLSAISSLLQYTLLQTQTPDEMLGRINGLWTAQNV 358

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 2796900831 374 GALPLGAGLVGLLAELADSRLAFGVFAVATTATVVPFL 411
Cdd:PRK10489  359 TGDAIGAALLGGLGAMMTPVASASASGFGLLIIGVLLL 396
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
235-422 7.96e-09

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 56.91  E-value: 7.96e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 235 WQNRVLRTLMLVVSVLNATWGAWLALLPLYAKEtLGLGPQEYGIALSALGIGGLTGALVVTRVNRLLGARGAMFADLIAT 314
Cdd:COG2814     7 RRWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 315 ITMVALPALTTSVWSIAVGAFLGGMGGTLWTVNSRTIAQRLVPDEMLGRFNATFRFFAFGALPLGAGLVGLLAELADSRL 394
Cdd:COG2814    86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165

                         170       180
                  ....*....|....*....|....*...
gi 2796900831 395 AFGVFAVATTATVVPFLRNITHSALESR 422
Cdd:COG2814   166 VFLVNAVLALLALLLLLRLLPESRPAAR 193
MFS_1 pfam07690
Major Facilitator Superfamily;
243-412 2.59e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 55.12  E-value: 2.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 243 LMLVVSVLNATWGAWLALLPLYAKETLGLGPQEYGIALSALGIGGLTGALVVTRVNRLLGARGAMFADLIATITMVALPA 322
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 323 LTTSVWSIAVGAFLGGMGGTLWTVNSRTIAQRLVPDEMLGRFNATFRFFAFGALPLGAGLVGLLAELADSRLAFGVFAVA 402
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170
                  ....*....|
gi 2796900831 403 TTATVVPFLR 412
Cdd:pfam07690 161 SLLAAVLLLL 170
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
243-412 1.01e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 53.72  E-value: 1.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 243 LMLVVSVLNATWGAWLALLPLYAKETLGLGPQEYGIALSALGIGGLTGALVVTRVNRLLGARGAMFADLIATITMVAL-- 320
Cdd:COG2271   185 LALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALll 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 321 PALTTSVWSIAVGAFLGGMGGTLWTVNSRTIAQRLVPDEMLGRFNATFRFFAFGALPLGAGLVGLLAELADSRLAFGVFA 400
Cdd:COG2271   265 LALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLA 344

                         170
                  ....*....|..
gi 2796900831 401 VATTATVVPFLR 412
Cdd:COG2271   345 ALALLAALLALL 356
MFS_1 pfam07690
Major Facilitator Superfamily;
50-380 5.09e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 51.26  E-value: 5.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831  50 PFLAAQLTDSPSQVTAVSLTLTLPWLLIALHIGVLVDRFDRRLLLWGANGMRLAAMGWLTASAlgggvTLTHLFAAGAIL 129
Cdd:pfam07690  21 LLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS-----SLWLLLVLRVLQ 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 130 GVADVLASTSAAALVPAAVPATARERANAWMLGAETVGFEFAGPFIGGLLLAAGAGLALGATSASYAVAALVLVLLVGRF 209
Cdd:pfam07690  96 GLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPP 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 210 QAARPVPGAApasVGSRIAEGLRFIWQNRVLRtLMLVVSVLNATWGAWLALLPLYAkETLGLGPQEYGIALSALGIGGLT 289
Cdd:pfam07690 176 ESKRPKPAEE---ARLSLIVAWKALLRDPVLW-LLLALLLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGAI 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 290 GALVVTRVNRLLGARGAMFADLIATIT---MVALPALTTSVWSIAVGAFLGGMGGTLWTVNSRTIAQRLVPDEMLGRFNA 366
Cdd:pfam07690 251 GRLLLGRLSDRLGRRRRLLLALLLLILaalGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASG 330

                         330
                  ....*....|....
gi 2796900831 367 TFRFFAFGALPLGA 380
Cdd:pfam07690 331 LYNTAGSLGGALGP 344
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
236-412 6.35e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 51.01  E-value: 6.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 236 QNRVLRTLMLVVSVLNATWGA----WLALLPlYAKETLGLGPQEYGIALSALGIGGLTGALVVTRVNRLLGARGAMFADL 311
Cdd:COG0738     2 SKKNYRRALIAIYLLFFLWGFatalWGPLIP-ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 312 IATITMVALPALTTSVWSIAVGAFLGGMGGTLWTVNSRTIAQRLVPDEMLGRFNATFRFFAFGALpLGAGLVGLLAELAD 391
Cdd:COG0738    81 LLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGAL-LGPLLGGLLILLGL 159

                         170       180
                  ....*....|....*....|....
gi 2796900831 392 S---RLAFGVFAVATTATVVPFLR 412
Cdd:COG0738   160 SlswHLPYLILAVLLLLLALLFLR 183
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 75-401 1.03e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 50.30  E-value: 1.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831  75 LLIALHIGVLVDRFDRRLLLWGANGMRLAAMGWLTASAlgggvTLTHLFAAGAILGVADVLASTSAAALVPAAVPATARE 154
Cdd:cd17329    49 IVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAH-----SPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRT 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 155 RANA---WMLGAETVgfefAGPFIGGLLLAAGAGLALGATSASYAVAALVLVLLVGRFQAARPVPGAAPasvgsrIAEGL 231
Cdd:cd17329   124 RAFSllyWAINLGVA----IGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTE------ILRGY 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 232 RFIWQNRVLRTLMLVVSVLNATWGAWLALLPLYAKETLGLGPQEYGIALSALGIGGLTGALVVTR-VNRLLGARGAMFAD 310
Cdd:cd17329   194 KIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARlVERFRLRKILMIGI 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 311 LIATITMVALpALTTSVWSIAVGAFLGGMGGTLWTVNSRTIAQRLVPDEMLGRFNATFRFFAFGALPLGAGLVGLLAELA 390
Cdd:cd17329   274 LLFAIGFAVL-AFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLL 352

                         330
                  ....*....|.
gi 2796900831 391 DSRLAFGVFAV 401
Cdd:cd17329   353 GPGLPWLILAA 363
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
25-402 1.07e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 50.62  E-value: 1.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831  25 RRNTAVLVGFTAVTSLADGVMKTTLPFLAAQLTDSPSQVTAVSLTLTLPWLLIALHIGVLVDRFDRRLLLWGAngmrlAA 104
Cdd:COG0738     7 RRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLG-----LL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 105 MGWLTASALGGGVTLTHLFAAGAILGVADVLASTSAAALVPAAVPATARERAN----AWMLGAetvgfeFAGPFIGGLLL 180
Cdd:COG0738    82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNllhaFFSLGA------LLGPLLGGLLI 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 181 AAGAGLAlgaTSASYAVAALVLVLLVGRFQAARPVPGAAPASVGSRIAEGLRFIWQNRVLRTLMLVVSVLNATWGAWLAL 260
Cdd:COG0738   156 LLGLSLS---WHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDW 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 261 LPLYAKETLGLGPQEYGIALSALGIGGLTGALVVTRVNRLLGARGAMFADLIATITMVALPALTTSVWSIAVGAFLGGMG 340
Cdd:COG0738   233 LPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLG 312

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2796900831 341 -GTLW-TVNSrtIAQRLVPDEMLGRFNATFRFFAFGALpLGAGLVGLLAELADSRLAFGVFAVA 402
Cdd:COG0738   313 lSLMFpTIFS--LALDGLGKRTAAAVSAVLIMGIVGGA-IGPPLIGFLADAFGLRAAFLVPLVC 373
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
218-390 1.40e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 50.29  E-value: 1.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 218 AAPASVGSRIAEGLRFIWQNRVLRTLMLVVSVLNATWGAWLALLPLYAKETLGLGPQEYGIALSALGIGGLTGALVVTRV 297
Cdd:COG2211   208 PVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRL 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 298 NRLLGARGAMFADLIATITMVALPAL--TTSVWSIAVGAFLGGMGGTLWTVNSRTIAQRLVPDEML-------GRFNATF 368
Cdd:COG2211   288 AKRFGKKKAFIIGLLLAALGLLLLFFlgPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWktgrrreGLYFGIF 367

                         170       180
                  ....*....|....*....|..
gi 2796900831 369 RFFAFGALPLGAGLVGLLAELA 390
Cdd:COG2211   368 TFAIKLGQALAGALAGLLLALF 389
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 47-408 1.27e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 46.82  E-value: 1.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831  47 TTLPFLAAQLTDSPSQVTAVSLTLTLPWLLIALHIGVLVDRFDRR-LLLWGANGMRLAAMGWLTASALGGgvtlthLFAA 125
Cdd:cd17489    17 PVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKrLLLIGLLIFALATLLYLLATSVAL------LLVL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 126 GAILGVADVLASTSAAALVPAAVPATARERANAWMLGAETVGFEFaGPFIGGLLLAAGAGLALGATSAsyavaalvlVLL 205
Cdd:cd17489    91 RLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMAL-GPALGLFLYQHLGFAVLFIVAA---------VLA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 206 VGRFQAARPVPGAAPASVGSRIAEGLRFIW-QNRVLRTLMLVVSVLNATWGAWLALLPLYAKEtlgLGPQEYGIALSALG 284
Cdd:cd17489   161 LLALLLVFLVKDPPPVAAEEAEAGTRAFRRlVEKKVLPPALILFLASIAYGAISTFLPLYAAE---RGISNAGLFFTVYA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 285 IGGLTGALVVTRVNRLLGARGAMFADLIATITMVALPALTTSVWSIAVGAFLGGMGGTLWTVNSRTIAQRLVPDEMLGRF 364
Cdd:cd17489   238 IALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAA 317

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 2796900831 365 NATfrFFAFGALPLGAG--LVGLLAELADSRLAFGVFAVATTATVV 408
Cdd:cd17489   318 NGT--FFIFFDLGIGLGglLLGLVAELFGYRAMFLLAAVVVLLALV 361
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 208-401 1.65e-05

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 46.68  E-value: 1.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 208 RFQAARPVPGAAPASVGSRIAEGLRFIWQNRVLRTLMLVVSVLNATWGAWLALLPLYAKETLGLGPQEYGIALSALGIGG 287
Cdd:COG2270   208 RPRPGPAPPRGAVRAGFRELRRTLRELRRYRDLLRFLLAYFFYRDGVQTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVA 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 288 LTGALVVTRVNRLLGARGAMFADLIATITMVALPALTTSVWSI-AVGAFLGGMGGTLWTVnSRTIAQRLVPDEMLGRF-- 364
Cdd:COG2270   288 ALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFwILGLLIGLVMGGIQAL-SRSLLARLIPPGREAEFfg 366

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2796900831 365 --NATFRFFAFgalpLGAGLVGLLAELADS-RLAFGVFAV 401
Cdd:COG2270   367 lyALSGKAASF----LGPLLFGLVTQLTGSqRLGILSLIV 402
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 224-419 2.29e-05

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 46.84  E-value: 2.29e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831  224 GSRIAEGLRFIWQNRVLrtlMLVVSVLNATWGA---WLALLPLYAKETLGLGPQE---YGIALSALGIGGltGALVVTRV 297
Cdd:PRK08633   218 PKLLWRNLKLLRSDRVL---WLAIIGLSYFWFIsqlAQANFPAYAKEVLGLDNTFqvqYLLAASAIGIGI--GSLLAGRL 292

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831  298 NRL--------LGARGAmfadliaTITMVALPALTtSVWSIAVGAFLGGMGGTLWTVNSRTIAQRLVPDEMLGRFNATFR 369
Cdd:PRK08633   293 SGRhielglvpLGALGL-------ALSLFLLPTAP-SLASVLVLFFLFGFSAGLFIVPLNALIQFRAPEKELGKVLAANN 364

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2796900831  370 FFAFGALPLGAGLVGLLAELADSRLA-FGVFAVATTATVVPFLRNITHSAL 419
Cdd:PRK08633   365 FLQNVGMLLFLALTTLFSGLGLSPAGlFYLIALVTLIGTLYTLLLLPDSLL 415
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 35-408 8.56e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 44.48  E-value: 8.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831  35 TAVTSLADGVMKTTLPFLAAQLTDSPSQVTAVSLTLTLPWLLIALHIGVLVDRFDRRLLLwgangmrLAAMGWLTASALG 114
Cdd:cd17474     8 TLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVL-------LPGLLLFGIGGLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 115 GGVT--LTHLFAAGAILGVADVLASTSAAALVPAAVPATARERA---NAWMLGAETVGFEFAGPFIGGLLLAAGAGLALG 189
Cdd:cd17474    81 CGLSdsFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAmglYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 190 ATSASYAVAALVLvllvgrfqaarPVPGAAPASVGSRIAEGLRFIWQNRVLRTLMLVVSVLNATWGAWLALLPLYAKETL 269
Cdd:cd17474   161 LIPVAFLAILFLL-----------PEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLY 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 270 GLGPQEYGIALSALGIGGLTGALVVTRVNRL-LGARGAMFADLIATITMVALPALTTSVWSIAVGAFLGGMGGTLWTVNS 348
Cdd:cd17474   230 GISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLL 309

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 349 RTIAQRLVPDEMLGRFNATFRFFAFGALPLGAGLVGLLAELADSRLAFGVFAVATTATVV 408
Cdd:cd17474   310 TTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAV 369
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 210-362 2.44e-04

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 42.98  E-value: 2.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 210 QAARPVPGAAPASVGSRIAEGLRFIWQNRVLRTLMLVVSVLNATWGAWLALLPLYAKETLGLGPQEYGIALSALGIGGL- 288
Cdd:cd17331   179 SKREKEAKESASPPSVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMv 258

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2796900831 289 TGALVVTRVNRLLGARGAMFADLIATITMVALPALTTSVWSIAVGAFLGGMGGTLWTVNSRTIAQRLVPDEMLG 362
Cdd:cd17331   259 VQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTG 332
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 238-419 2.74e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 42.93  E-value: 2.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 238 RVLRTLMLVVSVLNATWGAWLALLPLYAKETLGLGPQEYGIALSALGIGGLTGALVVTRVNRLLGARGAMFADLIATITM 317
Cdd:cd17321   168 RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVG 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 318 VALPALT---TSVWSIAVGAFLGGMG-GTLWTVNSRTIAQRlVPDEMLGRFNATFRFFAFGALPLGAGLVG-LLAELADS 392
Cdd:cd17321   248 LLLLALLgadSSVWLLLPGLVLLGLGlGLFATPLTNAALSS-VPKEKAGAASGILNTARQLGGALGVALLGaLLTAGLSA 326

                         170       180
                  ....*....|....*....|....*..
gi 2796900831 393 RLAFGVFAVATTATVVPFLRNITHSAL 419
Cdd:cd17321   327 NLGDSGVAALLSAAAAAFAAGFHLAFL 353
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 231-403 2.75e-04

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 42.94  E-value: 2.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 231 LRFIWQNRVLRTLMLVVSVLNATWGAWLAL--LPLYAKETLGLGPQEYGIALSALGIGGLTGALVVTRVN--RLLGARGA 306
Cdd:cd17319   170 LAVLWWFYLRQVWGLALGYFGINYALYGLLtwLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSdrLLRGARRL 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 307 M-FADLIATITMVALPALTTSVWSIAVGAFLGGMGGTLWTVNSRTIAQRLVPDEMLGRFNATFRFFAFGALPLGAGLVGL 385
Cdd:cd17319   250 ViIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGY 329

                         170
                  ....*....|....*....
gi 2796900831 386 LAELADS-RLAFGVFAVAT 403
Cdd:cd17319   330 LVDATGSyTAAFLFLAAVA 348
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 236-371 4.67e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 42.18  E-value: 4.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 236 QNRVLRTLMLVVSVLNATWGAWLALLPLYAKETLGLGPQEYGIALSALGIGGLTGALVVTRVNRLLGARGAMFADLI--- 312
Cdd:cd17503   176 KDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLlla 255

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2796900831 313 ATITMVALPALTTSVWSIAVGAFLGGMGGTLWTVNSRTIAQRLVPDEMLGRFNATFRFF 371
Cdd:cd17503   256 LGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTI 314
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 243-408 5.43e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.81  E-value: 5.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 243 LMLVVSVLNATWGAWLALLPLYAKEtLGLGPQEYGIALSALGIGGLTGALVVTRVNRLLGARGAMFADLIATITMVALPA 322
Cdd:cd17489     1 ILLANFFFFLSFYLLLPVLPLYAHD-LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 323 LTTSVWSIAVGAFLGGMGGTLWTVNSRTIAQRLVPDEMLGRFNATFRFFAFGALPLGAGLVGLLAELADSRLAFGVFAVA 402
Cdd:cd17489    80 LATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVL 159


                  ....*.
gi 2796900831 403 TTATVV 408
Cdd:cd17489   160 ALLALL 165
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 255-408 7.74e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 41.39  E-value: 7.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 255 GAWLALLPLYAKEtLGLGPQEYGIALSALGIGGLTGALVVT----RVNRLLGARGAMfadLIATITMVALPALTTSVWSI 330
Cdd:cd17477   205 GAFYSLLPLYGLR-LGLSVAQAALLLAAFVLGGLLLQWPLGwladRFDRRRVLLGCA---LLGALAALLLPLVPGLPLAL 280

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2796900831 331 AVGAFL-GGMGGTLWTVNSRTIAQRLVPDEMLGRFNATFRFFAFGALpLGAGLVGLLAELADSRLAFGVFAVATTATVV 408
Cdd:cd17477   281 LVLLFLwGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSV-IGPLLAGALMDAFGPHGLFLFLAAVALLFLL 358
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 243-411 8.30e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 41.39  E-value: 8.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 243 LMLVVSVLNATWGAWLALLPLYAKEtLGLGPQEYGIALSALGIGGLTGALVVTRVNRLLGARGAMFADLIATITMVALPA 322
Cdd:cd17477     1 LLLSVALLGLGSGLLLPLLSLRLER-EGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 323 LTTSVWSIAVGAFLGGMGGTLWTVNSRTIAQRLVPDEMLGRFNATFRFFAFGALPLGAGLVGLLAELADsrLAFGVFAVA 402
Cdd:cd17477    80 LTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGA--LPFLIAAVL 157


                  ....*....
gi 2796900831 403 TTATVVPFL 411
Cdd:cd17477   158 LLLALVPLL 166
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 216-405 1.09e-03

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 41.02  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 216 PGAAPASVGSRIAEGLRFIWQNRVLRTLMLVVSVLNATWGAWLALLPLYAKETLGLGPQEYGIALSALGIGGLTGALVVT 295
Cdd:cd17320   179 PEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNG 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 296 RVNRLLGAR----GAMFADLIATITMVALPALTT-SVWSIAVGAFL--GGMGGTLWTVNSRTIAQRlvpDEMLGRFNATF 368
Cdd:cd17320   259 RLVRRFGPRrllrLGLLLLLAAALVLLLAALLGGlSLWPLVAPLFLifFGFGLIFPNATSLALEPF---PHVAGTASALL 335

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2796900831 369 RFFAFGALPLGAGLVGLLAELADSRLAFGVFAVATTA 405
Cdd:cd17320   336 GFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLA 372
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
243-411 1.84e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 40.24  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 243 LMLVVSVLNATWGAWLALLPLYAKEtLGLGPQEYGIALSALGIGGLTGALVVTRVNRLLGARGAMFADLIATITMVALPA 322
Cdd:COG2807    23 IVLVALNLRPAITSVGPLLPEIRAD-LGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRS 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 323 LTTSVWSIAVGAFLGGMGGTLWTVNSRTIAQRLVPDE---MLGRFNATFRFFAFgalpLGAGLVGLLAELADSRLAFGVF 399
Cdd:COG2807   102 LAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRvglMTGLYTAAMGLGAA----LAAGLTVPLAAALGWRGALAVW 177

                         170
                  ....*....|..
gi 2796900831 400 AVATTATVVPFL 411
Cdd:COG2807   178 ALLALLALLLWL 189
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 259-412 1.98e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 40.23  E-value: 1.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 259 ALLPLYAKEtLGLGPQEYGIALSALGIGGLTGALVVTRVNRLLGARGAMFADLIATITMVALPALTTSVWSIAVGAFLGG 338
Cdd:cd17324    20 GLLPDIARD-FGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAG 98

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2796900831 339 MGGTLWTVNSRTIAQRLVPDEMLGRFNATFRFFAFGALPLGAGLVGLLAELADSRLAFGVFAVATTATVVPFLR 412
Cdd:cd17324    99 LAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWR 172
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 261-406 2.05e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 40.25  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 261 LPLYAKETLGLGPQEYGIALSALGIGGLTGALVVTRVNRLLGARGAMFADLIATITMVALPALTTSVWSIAVGAFLGGMG 340
Cdd:cd17473   220 LPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLG 299

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 341 GTLWTVNSRTIAQRLVPDEMLGR---FNATFRFFAFGALPLGAGLVGLLAE-LADSRLAFGVFAVATTAT 406
Cdd:cd17473   300 FGLLLPTLNSWAMSLVPPELRGRamgIVTSAFFLGQFLSPLVLGPLVNLTGgLSGAFLILGVLALVLAIV 369
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 238-367 2.93e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 39.48  E-value: 2.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 238 RVLRTLMLVVSVLNATWGAWLALLPLYAKETLGLGPQEYGIALSALGIGG-LTGALVVTRVNRLLGARGAMFADLIATIT 316
Cdd:cd17330   174 PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGiLAQLLLIPRLAKRLGERKLLRLGLLLAII 253

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2796900831 317 MVALPALTTSVWSIAVGAFLGGMGGTLWTVNSRTIAQRLVPDEMLGRFNAT 367
Cdd:cd17330   254 GLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGI 304
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 243-414 3.15e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 39.33  E-value: 3.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 243 LMLVVSVLNATWGAWLALLPLYAKEtLGLGPQEYGIALSALGIGGLTGALVVTRVNRLLGARGAMFADLIATITMVALPA 322
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQS-FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2796900831 323 LTTSVWSIAVGAFLGGMGGTLWTVNSRTIAQRLVPDEMLGRFNATFRFFAFGALPLGAGLVGLLAE--LADSRLAFGVFA 400
Cdd:cd06174    80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAA 159

                         170
                  ....*....|....
gi 2796900831 401 VATTATVVPFLRNI 414
Cdd:cd06174   160 ALALLAAILLLLVV 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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