|
Name |
Accession |
Description |
Interval |
E-value |
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
5-1298 |
0e+00 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 2887.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 5 QKLTFTALQQRLDSLMLRDRLRFSRRLHGVKKVKNPDAQQAIFQEMAKEIDQAAGKVLLREAARPEITYPDNLPVSQKKQ 84
Cdd:PRK11131 1 MKLTLTALQQQLDELMLRDRQRLSRRLHGAKKIKNPDAQQAIFQEIAKEIAQAAQRVLLREAARPEITYPENLPVSQKKQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 85 DILEAIRDHQVVIVAGETGSGKTTQLPKICMELGRGIKGLIGHTQPRRLAARTVANRIAEELKTEPGGCIGYKVRFSDHV 164
Cdd:PRK11131 81 DILEAIRDHQVVIVAGETGSGKTTQLPKICLELGRGVKGLIGHTQPRRLAARTVANRIAEELETELGGCVGYKVRFNDQV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 165 SDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLKELLPRRPDLKIIITSATIDPERFSRHFNNA 244
Cdd:PRK11131 161 SDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLKVIITSATIDPERFSRHFNNA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 245 PIIEVSGRTYPVEVRYRPIVEEADDTERDQLQAIFDAVDELSQESPGDILIFMSGEREIRDTADALNKLNLRHTEILPLY 324
Cdd:PRK11131 241 PIIEVSGRTYPVEVRYRPIVEEADDTERDQLQAIFDAVDELGREGPGDILIFMSGEREIRDTADALNKLNLRHTEILPLY 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 325 ARLSNSEQNRVFQSHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVS 404
Cdd:PRK11131 321 ARLSNSEQNRVFQSHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVS 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 405 EGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTTLGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAITTDEQASAY 484
Cdd:PRK11131 401 EGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAITTDEQASAY 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 485 KLTPLGRQLSQLPVDPRLARMVLEAQKHGCVREAMIITSALSIQDPRERPMDKQQASDEKHRRFHDKESDFLAFVNLWNY 564
Cdd:PRK11131 481 KLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRERPMDKQQASDEKHRRFADKESDFLAFVNLWNY 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 565 LGEQQKALSSNAFRRLCRTDYLNYLRVREWQDIYTQLRQVVKELGIPVNSEPAEYREIHIALLTGLLSHIGMKDADKQEY 644
Cdd:PRK11131 561 LQEQQKALSSNQFRRLCRTDYLNYLRVREWQDIYTQLRQVVKELGIPVNSEPAEYREIHTALLTGLLSHIGMKDAEKQEY 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 645 TGARNARFSIFPGSGLFKKPPKWVMVAELVETSRLWGRIAARIDPEWVEPVAQHLIKRTYSEPHWERAQGAVMATEKVTV 724
Cdd:PRK11131 641 TGARNARFSIFPGSGLFKKPPKWVMVAELVETSRLWGRIAARIEPEWIEPLAQHLIKRSYSEPHWEKAQGAVMATEKVTL 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 725 YGLPIVAARKVNYSQIDPALCRELFIRHALVEGDWQTRHAFFRENLKLRAEVEELEHKSRRRDILVDDETLFEFYDQRIS 804
Cdd:PRK11131 721 YGLPIVAARKVNYGQIDPALCRELFIRHALVEGDWQTRHAFFRENLKLRAEVEELEHKSRRRDILVDDETLFEFYDQRIG 800
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 805 HDVISARHFDSWWKKVSRETPDLLNFEKSMLIKEGAEKISKLDYPNFWHQGNLKLRLSYQFEPGADADGVTVHIPLPLLN 884
Cdd:PRK11131 801 HDVVSARHFDSWWKKASRETPELLNFEKSMLIKEGAEKVSKLDYPNFWHQGNLKLRLSYQFEPGADADGVTVHIPLPLLN 880
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 885 QVEESGFEWQIPGLRRELVIALIKSLPKPVRRNFVPAPNYAEAFLGRVKPLELPLLDSLERELRRMTGVTVDREDWHWDQ 964
Cdd:PRK11131 881 QVEESGFDWQIPGLRRELVIALIKSLPKPVRRNFVPAPNYAEAFLGRVTPLELPLLDSLERELRRMTGVTVDREDWQWDQ 960
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 965 VPDHLKITFRVVDDKNKKLKEGRSLQDLKDALKGKVQETLSAVADDGIEQSGLHIWSFGQLPESYEQKRGNYKVKAWPAL 1044
Cdd:PRK11131 961 VPDHLKITFRVVDDKNKKLAEGKDLQELKDALKGKVQETLSAVADDGIEQSGLHIWSFGELPESYEQKRGGYKVKAYPAL 1040
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 1045 VDERDSVAIKLFDNPLEQKQAMWNGLRRLLLLNIPSPIKYLHEKLPNKAKLGLYFNPYGKVLELIDDCISCGVDQLIDAN 1124
Cdd:PRK11131 1041 VDEKDSVAIKLFDTELEQQQAMWQGLRRLLLLNIPSPIKYLHEKLPNKAKLGLYFNPYGKVLDLIDDCIACGVDKLIDEN 1120
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 1125 GGPVWTEEGFAALHEKVRAELNDTVVDIAKQVEQILTAVFNINKRLKGRVDMTMALGLSDIKAQMGGLVYRGFVTGNGFK 1204
Cdd:PRK11131 1121 GGPVWTEEGFAALHEKVRAELNDTVVDIAKQVEQILTAVFNINKRLKGRVDMTMALALSDIKAQMGGLVYRGFVTGNGWK 1200
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 1205 RLGDTLRYLQAIEKRLEKLAVDPHRDRAQMLKVENVQQAWQQWINKLPPARREDEAVKEIRWMIEELRVSYFAQQLGTPY 1284
Cdd:PRK11131 1201 RLGDTLRYLQAIEKRLEKLAVDPHRDRAQMLKVESVQQAWQQWLNKLPPARREDEDVKEIRWMIEELRVSYFAQQLGTPY 1280
|
1290
....*....|....
gi 2755933196 1285 PISDKRILQAMEQI 1298
Cdd:PRK11131 1281 PISDKRILQAMEQI 1294
|
|
| DEAH_box_HrpA |
TIGR01967 |
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ... |
12-1297 |
0e+00 |
|
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273900 [Multi-domain] Cd Length: 1283 Bit Score: 2331.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 12 LQQRLDSLMLRDRLRFSRRLHGVKKVKNPDAQQAIFQEMAKEIDQAAGKVLLREAARPEITYPDNLPVSQKKQDILEAIR 91
Cdd:TIGR01967 1 LAEDLDHTMIRDRHRLRRRLHKLRKDHDQDRAIAALAKFRERIDAACDKVEARRQAVPEIRYPDNLPVSAKREDIAEAIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 92 DHQVVIVAGETGSGKTTQLPKICMELGRGIKGLIGHTQPRRLAARTVANRIAEELKTEPGGCIGYKVRFSDHVSDNTMVK 171
Cdd:TIGR01967 81 ENQVVIIAGETGSGKTTQLPKICLELGRGSHGLIGHTQPRRLAARTVAQRIAEELGTPLGEKVGYKVRFHDQVSSNTLVK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 172 LMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLKELLPRRPDLKIIITSATIDPERFSRHFNNAPIIEVSG 251
Cdd:TIGR01967 161 LMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKIIITSATIDPERFSRHFNNAPIIEVSG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 252 RTYPVEVRYRPIVEEADDTERDQLQAIFDAVDELSQESPGDILIFMSGEREIRDTADALNKLNLRHTEILPLYARLSNSE 331
Cdd:TIGR01967 241 RTYPVEVRYRPLVEEQEDDDLDQLEAILDAVDELFAEGPGDILIFLPGEREIRDAAEILRKRNLRHTEILPLYARLSNKE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 332 QNRVFQSHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRL 411
Cdd:TIGR01967 321 QQRVFQPHSGRRIVLATNVAETSLTVPGIHYVIDTGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 412 YSEDDFLSRPEFTDPEILRTNLASVILQMTTLGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAITTDEQAsaYKLTPLGR 491
Cdd:TIGR01967 401 YSEEDFNSRPEFTDPEILRTNLASVILQMLALRLGDIAAFPFIEAPDPRAIRDGFRLLEELGALDDDEAE--PQLTPIGR 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 492 QLSQLPVDPRLARMVLEAQKHGCVREAMIITSALSIQDPRERPMDKQQASDEKHRRFHDKESDFLAFVNLWNYLGEQQKA 571
Cdd:TIGR01967 479 QLAQLPVDPRLARMLLEAHRLGCLQEVLIIASALSIQDPRERPMEKQQAADQAHARFKDPRSDFLSRVNLWRHIEEQRQA 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 572 LSSNAFRRLCRTDYLNYLRVREWQDIYTQLRQVVKELGIPVNSEPAEYREIHIALLTGLLSHIGMKDAdKQEYTGARNAR 651
Cdd:TIGR01967 559 LSANQFRNACRKQYLNYLRVREWQDIYRQLTQVVKELGLKLNEEPADYDAIHKALLSGLLSQIGMKDE-KHEYDGARGRK 637
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 652 FSIFPGSGLFKKPPKWVMVAELVETSRLWGRIAARIDPEWVEPVAQHLIKRTYSEPHWERAQGAVMATEKVTVYGLPIVA 731
Cdd:TIGR01967 638 FHIFPGSPLFKKPPKWVMAAELVETSKLYARLVAKIEPEWVEPVAGHLIKKNYFEPHWEKKRGQVMAYEKVTLYGLTLVA 717
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 732 ARKVNYSQIDPALCRELFIRHALVEGDWQTRHAFFRENLKLRAEVEELEHKSRRRDILVDDETLFEFYDQRISHDVISAR 811
Cdd:TIGR01967 718 RRSVPYGPIDPADAREMFIRHALVEGEWQTRAAFFQANRALLEEVEELEHKARRRDILVDEQTLFDFYDGRLPEDINNAR 797
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 812 HFDSWWKKVSRETPDLLNFEKSMLIKEGAEKISKLDYPNFWHQGNLKLRLSYQFEPGADADGVTVHIPLPLLNQVEESGF 891
Cdd:TIGR01967 798 HFDSWWKKASRKQPDLLDFPKEVLFQRRANVISAAQFPDHWHKGDLRLALSYHFEPGHGDDGVTVHIPLPLLNQLDTEDF 877
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 892 EWQIPGLRRELVIALIKSLPKPVRRNFVPAPNYAEAFLGRVKPLELPLLDSLERELRRMTGVTVDREDWHWDQVPDHLKI 971
Cdd:TIGR01967 878 DWLVPGLREEKVVALIKSLPKALRRNFVPAPDFAKACLARLPPNQGPLTDALARELRRMTGERVNPEDWDWEQLPDHLQM 957
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 972 TFRVVDDKNKKLKEGRSLQDLKDALKGKVQETLSAVADDGIEQSGLHIWSFGQLPESYEQKRGNYKVKAWPALVDERDSV 1051
Cdd:TIGR01967 958 NFRIVDDKGKVLAQGRDLALLKERLAGDVRAALSAVADVGIEKSGLTNWSFGPLPERMEQKTGNYKVTAYPALVDDGGSV 1037
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 1052 AIKLFDNPLEQKQAMWNGLRRLLLLNIPSPIKYLHEKLPNKAKLGLYFNPYGKVLELIDDCISCGVDQLIDANGGPVWTE 1131
Cdd:TIGR01967 1038 AIKLFDTQAEAEAAHRAGLRRLLLLQIPSPVKMLQGKLPNKAKLALYYNPLGRVEVLVDDILHAAVDRLIFENGGQVRTQ 1117
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 1132 EGFAALHEKVRAELNDTVVDIAKQVEQILTAVFNINKRLKGRVDMTMALGLSDIKAQMGGLVYRGFVTGNGFKRLGDTLR 1211
Cdd:TIGR01967 1118 ADFAALLAQVRAELAPEVERIAKQLEEILVLFGNIRKRLKGKIDPTQAKALSDIKAQLDKLVYQGFVRTTGPQRLSHLPR 1197
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 1212 YLQAIEKRLEKLAVDPHRDRAQMLKVENVQQAWQQWINKLPPARREDEAVKEIRWMIEELRVSYFAQQLGTPYPISDKRI 1291
Cdd:TIGR01967 1198 YLKAMELRLEKLRVDPGRDRERQAEISNVQEAYDARLAKLPHERRLPAALVEIRWMIEEYRVSLFAQQLGTAYPISDKRI 1277
|
....*.
gi 2755933196 1292 LQAMEQ 1297
Cdd:TIGR01967 1278 LKYYRQ 1283
|
|
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
71-934 |
0e+00 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 1150.98 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 71 ITYPDNLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICMELGRGIKGLIGHTQPRRLAARTVANRIAEELKTEP 150
Cdd:COG1643 4 ITYPPDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAGGRIGMLEPRRLAARAAAERMAEELGEPV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 151 GGCIGYKVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLKELLPR-RPDLKIIITS 229
Cdd:COG1643 84 GETVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPAlRPDLKLLVMS 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 230 ATIDPERFSRHFNNAPIIEVSGRTYPVEVRYRPIVEEaddtERDQLQAIFDAVDELSQESPGDILIFMSGEREIRDTADA 309
Cdd:COG1643 164 ATLDAERFARLLGDAPVIESSGRTYPVEVRYRPLPAD----ERDLEDAVADAVREALAEEPGDILVFLPGEREIRRTAEA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 310 LNKLNLRHTEILPLYARLSNSEQNRVFQS--HSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEP 387
Cdd:COG1643 240 LRGRLPPDTEILPLYGRLSAAEQDRAFAPapHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTER 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 388 ISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTTLGLGDIAAFPFVEAPDKRNIQDGVR 467
Cdd:COG1643 320 ISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPARAIADARA 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 468 LLEELGAITTDeqasaYKLTPLGRQLSQLPVDPRLARMVLEAQKHGCVREAMIITSALSIQDPRerpmdKQQASdekhrr 547
Cdd:COG1643 400 LLQELGALDAD-----GRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPR-----RGAAG------ 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 548 fhdkeSDFLAFVNLWNYLGEQQKAlssnafrrlcrtdYLNYLRVREWQDIYTQLRQVVKElgiPVNSEPAEYREIHIALL 627
Cdd:COG1643 464 -----SDLLARLNLWRRLREQQRE-------------FLSYLRLREWRDLARQLRRLLGE---GANEEPADYEAIGLLLA 522
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 628 TGLLSHIGMKDADKQEYTGARNARFSIFPGSGLFKKPpkWVMVAELVETSR-LWGRIAARIDPEWVEPVAQHLIKRtYSE 706
Cdd:COG1643 523 LAYPDRIARRRGEGGRYLLARGRGAALFPGSPLAKKE--WLVAAELVGGAAeARIRLAAPIDPEWLEELAAHLIKR-YSE 599
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 707 PHWERAQGAVMATEKVTVYGLPIVAARKvnySQIDPALCRELFIRHALVEGDwqTRHAFFRENLKLRAEVEELEHKS--R 784
Cdd:COG1643 600 PHWDKKRGRVVARERVRLGALVLVSRPL---PGPDPEAAREALLRALRREGL--DLLPWSKAARQLRARVEFLERKLgeR 674
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 785 RRDilVDDETLfefydqrishdvisARHFDSWWKKVSRETPDLLNFEKSMLIKE-----GAEKISKLD--YPNFWHQ-GN 856
Cdd:COG1643 675 WPD--VSDEAL--------------LATLEDWLAPYLTGVRSLKDLKRLDLLAAlrallPWEQQQRLDelAPTHLTVpSG 738
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 857 LKLRLSY-------------QF----EPGAdADGvTVHIPLPLLNQV-EESGFEWQIPGLRRELVIALIKSLPKPVRRNF 918
Cdd:COG1643 739 SRLPLDYsadgppvavrlqeLFglaeTPGV-ADG-RVPVPLHLLSPAgRPLQVTWDLPGFWRGSYAEVRKELRGRYPKHP 816
|
890
....*....|....*...
gi 2755933196 919 VpaPNYA--EAFLGRVKP 934
Cdd:COG1643 817 W--PDDPaaAAPTRRTKR 832
|
|
| DUF3418 |
pfam11898 |
Domain of unknown function (DUF3418); This presumed domain is functionally uncharacterized. ... |
713-1295 |
0e+00 |
|
Domain of unknown function (DUF3418); This presumed domain is functionally uncharacterized. This domain is found in bacteria. This domain is typically between 582 to 594 amino acids in length. This domain is found associated with pfam07717, pfam00271, pfam04408.
Pssm-ID: 463389 Cd Length: 587 Bit Score: 898.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 713 QGAVMATEKVTVYGLPIVAARKVNYSQIDPALCRELFIRHALVEGDWQTRHAFFRENLKLRAEVEELEHKSRRRDILVDD 792
Cdd:pfam11898 2 RGAVMAYERVTLYGLPIVARRRVNYGRIDPEEAREIFIRHALVEGEWRTRHTFFAHNRKLLEEVEELEHKARRRDILVDD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 793 ETLFEFYDQRISHDVISARHFDSWWKKVSRETPDLLNFEKSMLIKEGAEKISKLDYPNFWHQGNLKLRLSYQFEPGADAD 872
Cdd:pfam11898 82 ETLFDFYDARLPADVVSGRHFDKWWKKARREDPDLLDLTREDLLRHEADAVTEEDFPDTWGLGGLRLPLSYRFEPGAEDD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 873 GVTVHIPLPLLNQVEESGFEWQIPGLRRELVIALIKSLPKPVRRNFVPAPNYAEAFLGRV---KPLELPLLDSLERELRR 949
Cdd:pfam11898 162 GVTVTVPLALLNQVSPERFDWLVPGLLEEKVTALIKSLPKALRRNFVPAPDFARAALARLerePPGDGPLLDALARALRR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 950 MTGVTVDREDWHWDQVPDHLKITFRVVDDKNKKLKEGRSLQDLKDALKGKVQETLSAVADDGIEQSGLHIWSFGQLPESY 1029
Cdd:pfam11898 242 LTGVRVPPDDWDLDALPPHLRMNFRVVDDRGKVLAEGRDLAALKARLAGQARAAFAAAAAASLERTGLTSWDFGDLPETV 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 1030 EQKRGNYKVKAWPALVDERDSVAIKLFDNPLEQKQAMWNGLRRLLLLNIPSPIKYLHEKLPNKAKLGLYFNPYGKVLELI 1109
Cdd:pfam11898 322 ELKRGGQEVTGYPALVDEGDSVALRLFDTPAEAAAAHRAGVRRLLLLALPSPVKYLEKNLPNLQKLALAYNPLGSVEALV 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 1110 DDCISCGVDQLIDANGGPVWTEEGFAALHEKVRAELNDTVVDIAKQVEQILTAVFNINKRLKGRVDMTMALGLSDIKAQM 1189
Cdd:pfam11898 402 DDLIAAALDRLFLEPVPLPRDEAAFEALLEEVRARLPDTAQEVARLVEEILAAYQALRKRLKGKKSLALAAALADIRAQL 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 1190 GGLVYRGFVTGNGFKRLGDTLRYLQAIEKRLEKLAVDPHRDRAQMLKVENVQQAWQQWINKLPPARREDEAVKEIRWMIE 1269
Cdd:pfam11898 482 DRLVPPGFVAATPWERLAHLPRYLKAIELRLEKLPADPARDRQRMAEVAPLEQRYQALLAKLPAGRPDPEELEEFRWMLE 561
|
570 580
....*....|....*....|....*.
gi 2755933196 1270 ELRVSYFAQQLGTPYPISDKRILQAM 1295
Cdd:pfam11898 562 ELRVSLFAQELGTPYPVSEKRLEKAW 587
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
77-249 |
2.54e-117 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 362.54 E-value: 2.54e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICMELGRGIKGLIGHTQPRRLAARTVANRIAEELKTEPGGCIGY 156
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLELGRGIRGLIGHTQPRRLAARSVAERIAEELKTELGGAVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 157 KVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLKELLPRRPDLKIIITSATIDPER 236
Cdd:cd17989 81 KVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSATIDAER 160
|
170
....*....|...
gi 2755933196 237 FSRHFNNAPIIEV 249
Cdd:cd17989 161 FSRHFNNAPIIEV 173
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
77-525 |
2.85e-99 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 336.13 E-value: 2.85e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPkicMEL--GRGIKGLIGHTQPRRLAARTVANRIAEELKTEPGGCI 154
Cdd:PRK11664 4 LPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLP---LQLlqHGGINGKIIMLEPRRLAARNVAQRLAEQLGEKPGETV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 155 GYKVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLKEL---LprRPDLKIIITSAT 231
Cdd:PRK11664 81 GYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVqqgL--RDDLKLLIMSAT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 232 IDPERFSRHFNNAPIIEVSGRTYPVEVRYRPIveeaddTERDQL-QAIFDAVDELSQESPGDILIFMSGEREIRDTADAL 310
Cdd:PRK11664 159 LDNDRLQQLLPDAPVIVSEGRSFPVERRYQPL------PAHQRFdEAVARATAELLRQESGSLLLFLPGVGEIQRVQEQL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 311 NKLNLRHTEILPLYARLSNSEQNRVFQ-SHSGRR-IVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPI 388
Cdd:PRK11664 233 ASRVASDVLLCPLYGALSLAEQQKAILpAPAGRRkVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQRI 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 389 SQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTTLGLGDIAAFPFVEAPDKRNIQDGVRL 468
Cdd:PRK11664 313 SQASMTQRAGRAGRLEPGICLHLYSKEQAERAAAQSEPEILHSDLSGLLLELLQWGCHDPAQLSWLDQPPAAALAAAKRL 392
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 2755933196 469 LEELGAITTDEQasaykLTPLGRQLSQLPVDPRLARMVLEAQKHGcvrEAMIITSAL 525
Cdd:PRK11664 393 LQQLGALDGQGR-----LTARGRKMAALGNDPRLAAMLVAAKEDD---EAALATAAK 441
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
93-249 |
1.47e-78 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 255.46 E-value: 1.47e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 93 HQVVIVAGETGSGKTTQLPKICME--LGRGIKGLIGHTQPRRLAARTVANRIAEELKTEPGGCIGYKVRFSDHVSDNTMV 170
Cdd:cd17917 1 NQVVVIVGETGSGKTTQVPQFLLEdgLAKGGKGRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKTRI 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2755933196 171 KLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLKELLPRRPDLKIIITSATIDPERFSRHFNNAPIIEV 249
Cdd:cd17917 81 KFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGGAPVIHI 159
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
77-247 |
6.24e-64 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 214.91 E-value: 6.24e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICMELGRGIKGLIGHTQPRRLAARTVANRIAEELKTEPGGCIGY 156
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFARGGMIGITQPRRVAAVSVAKRVAEEMGVELGQLVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 157 KVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLKELLPRR-----PDLKIIITSAT 231
Cdd:cd17978 81 SVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRkeqklSPLKVIIMSAT 160
|
170
....*....|....*.
gi 2755933196 232 IDPERFSRHFNNAPII 247
Cdd:cd17978 161 LDADLFSEYFNGAPVL 176
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
254-412 |
8.92e-64 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 213.93 E-value: 8.92e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 254 YPVEVRYRPIVEEA-----DDTERDQLQAIFDAVDELSQ-ESPGDILIFMSGEREIRDTADALNKL----NLRHTEILPL 323
Cdd:cd18791 1 FPVEVYYLEDILELlgissEKEDPDYVDAAVRLILQIHRtEEPGDILVFLPGQEEIERLCELLREEllspDLGKLLVLPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 324 YARLSNSEQNRVFQSHSG--RRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCG 401
Cdd:cd18791 81 HSSLPPEEQQRVFEPPPPgvRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAG 160
|
170
....*....|.
gi 2755933196 402 RVSEGICIRLY 412
Cdd:cd18791 161 RTRPGKCYRLY 171
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
77-249 |
1.03e-62 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 211.17 E-value: 1.03e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICMELGRGIKGLIGHTQPRRLAARTVANRIAEELKTEPGGCIGY 156
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGYTDYGMIGCTQPRRVAAMSVAKRVSEEMGVELGEEVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 157 KVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLKELLPRRPDLKIIITSATIDPER 236
Cdd:cd17983 81 AIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVTSATMDADK 160
|
170
....*....|...
gi 2755933196 237 FSRHFNNAPIIEV 249
Cdd:cd17983 161 FADFFGNVPIFTI 173
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
77-249 |
3.31e-61 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 207.27 E-value: 3.31e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICME--LGRGIKGLIGHTQPRRLAARTVANRIAEELKTEPGGCI 154
Cdd:cd17973 13 LPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDdeLPHQPKKLVACTQPRRVAAMSVAQRVAEEMDVKLGEEV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 155 GYKVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLKELLPRRPDLKIIITSATIDP 234
Cdd:cd17973 93 GYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPDLKLIVMSATLDA 172
|
170
....*....|....*
gi 2755933196 235 ERFSRHFNNAPIIEV 249
Cdd:cd17973 173 GKFQKYFDNAPLLKV 187
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
75-249 |
1.27e-60 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 205.41 E-value: 1.27e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 75 DNLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICMELGRGIKGLIGHTQPRRLAARTVANRIAEELKTEPGGCI 154
Cdd:cd17971 4 ESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYTSRGKIGCTQPRRVAAMSVAKRVAEEFGCCLGQEV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 155 GYKVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLKELLPRRPDLKIIITSATIDP 234
Cdd:cd17971 84 GYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLIVTSATLDA 163
|
170
....*....|....*
gi 2755933196 235 ERFSRHFNNAPIIEV 249
Cdd:cd17971 164 VKFSQYFYEAPIFTI 178
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
77-249 |
1.79e-57 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 196.18 E-value: 1.79e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICMELGRGIKGL-IGHTQPRRLAARTVANRIAEELKTEPGGCIG 155
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYTKGGGkIGCTQPRRVAAMSVAARVAEEMGVKLGNEVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 156 YKVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLKELLPRRPDLKIIITSATIDPE 235
Cdd:cd17974 81 YSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLISSATMDAE 160
|
170
....*....|....
gi 2755933196 236 RFSRHFNNAPIIEV 249
Cdd:cd17974 161 KFSAFFDDAPIFRI 174
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
77-249 |
7.86e-57 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 194.88 E-value: 7.86e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICMELGRGIK-----GLIGHTQPRRLAARTVANRIAEELkTEPG 151
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPesdnpGMIGITQPRRVAAVSMAKRVAEEL-NVFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 152 GCIGYKVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLKELLPRRPD--------- 222
Cdd:cd17982 80 KEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKlylqdqtvk 159
|
170 180 190
....*....|....*....|....*....|..
gi 2755933196 223 -LKIIITSATIDPERFS---RHFNNAP-IIEV 249
Cdd:cd17982 160 pLKLVIMSATLRVEDFTenkLLFPRPPpVIKV 191
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
77-249 |
3.19e-53 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 184.29 E-value: 3.19e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICMELGRGIKGLIGHTQPRRLAARTVANRIAEELKTEPGGCIGY 156
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHGMIGVTQPRRVAAISVAQRVAEEMKCTLGSKVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 157 KVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLKELLP-----RRPDLKIIITSAT 231
Cdd:cd17984 81 QVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQekspnRKEHLKVVVMSAT 160
|
170
....*....|....*...
gi 2755933196 232 IDPERFSRHFNNAPIIEV 249
Cdd:cd17984 161 LELAKLSAFFGNCPVFDI 178
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
77-249 |
1.12e-52 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 182.26 E-value: 1.12e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICMELGRGikgLIGHTQPRRLAARTVANRIAEELKTEPGGCIGY 156
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFR---HIACTQPRRIACISLAKRVAFESLNQYGSKVAY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 157 KVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLKELLPRRPDLKIIITSATIDPER 236
Cdd:cd17979 78 QIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSATINIEL 157
|
170
....*....|...
gi 2755933196 237 FSRHFNNAPIIEV 249
Cdd:cd17979 158 FSGYFEGAPVVQV 170
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
77-242 |
3.48e-51 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 178.43 E-value: 3.48e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICMELGRGIKG-LIGHTQPRRLAARTVANRIAEELKTEPGGCIG 155
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAGWTAGGrVVGCTQPRRVAAVTVAGRVAEEMGAVLGHEVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 156 YKVRFSDHVSD-NTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLKELLPRRPDLKIIITSATIDP 234
Cdd:cd17980 81 YCIRFDDCTDPqATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVASATLDA 160
|
....*...
gi 2755933196 235 ERFSRHFN 242
Cdd:cd17980 161 EKFRDFFN 168
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
77-249 |
3.36e-48 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 170.10 E-value: 3.36e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICME-----LGRGIKGLIGHTQPRRLAARTVANRIAEELKTE-- 149
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEdlllnGGTAQKCNIVCTQPRRISAMSLATRVCEELGCEsg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 150 PGG----CiGYKVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLKELLPRRPDLKI 225
Cdd:cd17975 81 PGGknslC-GYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHL 159
|
170 180
....*....|....*....|....
gi 2755933196 226 IITSATIDPERFSRHFNNAPIIEV 249
Cdd:cd17975 160 ILMSATVDCEKFSSYFTHCPILRI 183
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
77-249 |
2.77e-44 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 158.47 E-value: 2.77e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKIC----MELGRGIKGLIGHTQPRRLAARTVANRIAEElKTEP-- 150
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFIlddaIERGKGSSCRIVCTQPRRISAISVAERVAAE-RAEScg 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 151 -GGCIGYKVRFSDHVSDN-TMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLKELLPRRPDLKIIIT 228
Cdd:cd17981 80 lGNSTGYQIRLESRKPRKqGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILM 159
|
170 180
....*....|....*....|.
gi 2755933196 229 SATIDPERFSRHFNNAPIIEV 249
Cdd:cd17981 160 SATLNAEKFSDYFNNCPMIHI 180
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
77-249 |
7.15e-44 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 157.30 E-value: 7.15e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICME--LGRGIKGLIGHTQPRRLAARTVANRIAEELKTEPGGCI 154
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDdcYANGIPCRIFCTQPRRLAAIAVAERVAAERGEKIGQTV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 155 GYKVRFSDHVSDNTMVKLMTDGILLAEIQQ-DRLLMQYDTIIIDEAHERSLNIDFLLGYLKELLPRRPDLKIIITSATID 233
Cdd:cd17987 81 GYQIRLESRVSPKTLLTFCTNGVLLRTLMAgDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILSSAALD 160
|
170
....*....|....*.
gi 2755933196 234 PERFSRHFNNAPIIEV 249
Cdd:cd17987 161 VNLFIRYFGSCPVIYI 176
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
77-249 |
7.44e-42 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 151.33 E-value: 7.44e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICMELGRGIKGLIGHTQPRRLAARTVANRIAEELKTEPGGCIGY 156
Cdd:cd17990 1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAGGKIIVLEPRRVAARAAARRLATLLGEAPGETVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 157 KVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLKELLP-RRPDLKIIITSATIDPE 235
Cdd:cd17990 81 RVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQlLRDDLRLLAMSATLDGD 160
|
170
....*....|....
gi 2755933196 236 RFSRHFNNAPIIEV 249
Cdd:cd17990 161 GLAALLPEAPVVES 174
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
77-249 |
3.17e-41 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 149.94 E-value: 3.17e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICME----LGRGIKGLIGHTQPRRLAARTVANRIAEELKTEPGG 152
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEdyvlRGRGARCNVVITQPRRISAVSVAQRVAHELGPNLRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 153 CIGYKVRF-SDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLKELLPRRPDLKIIITSAT 231
Cdd:cd17976 81 NVGYQVRLeSRPPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMSAT 160
|
170
....*....|....*...
gi 2755933196 232 IDPERFSRHFNNAPIIEV 249
Cdd:cd17976 161 GDNQRLSRYFGGCPVVRV 178
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
77-249 |
2.14e-40 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 147.29 E-value: 2.14e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICME--LGRGIKGL--IGHTQPRRLAARTVANRIAEELKTEPGG 152
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDnsLQGPPLPVanIICTQPRRISAISVAERVAQERAERVGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 153 CIGYKVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLKELLPRRPDLKIIITSATI 232
Cdd:cd17985 81 SVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILMSATL 160
|
170
....*....|....*..
gi 2755933196 233 DPERFSRHFNNAPIIEV 249
Cdd:cd17985 161 NAELFSDYFNSCPVIHI 177
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
77-249 |
2.32e-38 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 141.49 E-value: 2.32e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICME--LGRGIKGLIGHTQPRRLAARTVANRIAEELKTEPGGCI 154
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDhyYKRGKYCNIVVTQPRRIAAISIARRVSQEREWTLGSLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 155 GYKVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLKELLPRRPD-LKIIITSATID 233
Cdd:cd17988 81 GYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSRhVKIILMSATIS 160
|
170 180
....*....|....*....|
gi 2755933196 234 PERFSRHF----NNAPIIEV 249
Cdd:cd17988 161 CKEFADYFttpnNPAYVFEV 180
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
77-249 |
1.14e-36 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 138.81 E-value: 1.14e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICMEL----GRGIKGLIGHTQPRRLAARTVANRIAEELKTEPGG 152
Cdd:cd17972 59 LPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDDfiqnDRAAECNIVVTQPRRISAVSVAERVAFERGEEVGK 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 153 CIGYKVRFsDHVSDNTMVKLM--TDGILLAEIQQDrlLMQYDTIIIDEAHERSLNIDFLLGYLKELLPRRPDLKIIITSA 230
Cdd:cd17972 139 SCGYSVRF-ESVLPRPHASILfcTVGVLLRKLEAG--IRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPDLRVILMSA 215
|
170
....*....|....*....
gi 2755933196 231 TIDPERFSRHFNNAPIIEV 249
Cdd:cd17972 216 TIDTSMFCEYFFNCPVIEV 234
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
77-249 |
1.90e-33 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 127.25 E-value: 1.90e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 77 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICMELGRGIK---GLIGHTQPRRLAARTVANRIAEELKTEPGGC 153
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYCLSAHyqhGVVVCTQVHKQTAVWLALRVADEMDVNIGHE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 154 IGYKVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLKELLPRRPDLKIIITSATID 233
Cdd:cd17977 81 VGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKLVIITCPHL 160
|
170
....*....|....*.
gi 2755933196 234 PERFSRHFNNAPIIEV 249
Cdd:cd17977 161 SSKLLSYYGNVPLIEV 176
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
77-249 |
2.29e-31 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 121.54 E-value: 2.29e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 77 LPVSQKKQDILEAIRDHQ-VVIVAGETGSGKTTQLPKICME--LGRGI-KGLIGHTQPRRLAARTVANRIAEELKTEPGG 152
Cdd:cd17986 1 LPIWAAKFTFLEQLESPSgIVLVSGEPGSGKSTQVPQWCAEfaLSRGFqKGQVTVTQPHPLAARSLALRVADEMDLNLGH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 153 CIGYKVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLKELLPRRPDLKIIITSATI 232
Cdd:cd17986 81 EVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRVVVVTSPA 160
|
170
....*....|....*..
gi 2755933196 233 DPERFSRHFNNAPIIEV 249
Cdd:cd17986 161 LEPKLRAFWGNPPVVHV 177
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
471-559 |
2.20e-27 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 106.58 E-value: 2.20e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 471 ELGAITTDEQasaykLTPLGRQLSQLPVDPRLARMVLEAQKHGCVREAMIITSALSIQDPRERpmDKQQASDEKHRRFHD 550
Cdd:smart00847 1 ELGALDDDGR-----LTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPRPK--EKREDADAARRRFAD 73
|
....*....
gi 2755933196 551 KESDFLAFV 559
Cdd:smart00847 74 PESDHLTLL 82
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
86-261 |
1.61e-23 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 99.87 E-value: 1.61e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 86 ILEAIRDHQVVIVAGETGSGKTTQLPKICMELGR---GIKGLIghTQPRRLAARTVANRIAEELKTEPGGCIGY------ 156
Cdd:smart00487 17 IEALLSGLRDVILAAPTGSGKTLAALLPALEALKrgkGGRVLV--LVPTRELAEQWAEELKKLGPSLGLKVVGLyggdsk 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 157 KVRFSDHVSDNTMVKLMTDGILLAEIQQDRL-LMQYDTIIIDEAHERS--LNIDFLLGYLKELlprRPDLKIIITSATI- 232
Cdd:smart00487 95 REQLRKLESGKTDILVTTPGRLLDLLENDKLsLSNVDLVILDEAHRLLdgGFGDQLEKLLKLL---PKNVQLLLLSATPp 171
|
170 180 190
....*....|....*....|....*....|
gi 2755933196 233 -DPERFSRHFNNAPIIEVSGRTYPVEVRYR 261
Cdd:smart00487 172 eEIENLLELFLNDPVFIDVGFTPLEPIEQF 201
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
466-558 |
8.91e-22 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 91.14 E-value: 8.91e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 466 VRLLEELGAITTDEQasaykLTPLGRQLSQLPVDPRLARMVLEAQKHGCVREAMIITSALSIQDPRERPMDKQQASDEKH 545
Cdd:pfam04408 2 LELLYYLGALDEDGE-----LTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFLDPRSAAKA 76
|
90 100
....*....|....*....|....*...
gi 2755933196 546 RR---------------FHDKESDFLAF 558
Cdd:pfam04408 77 ARrrrraadekarakfaRLDLEGDHLTL 104
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
622-699 |
1.39e-17 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 78.45 E-value: 1.39e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 622 IHIALLTGLLSHIGMKDADKQEYTGAR-NARFSIFPGSGLF---KKPPKWVMVAELVETSRLWGRIAARIDPEWVEPVAQ 697
Cdd:pfam07717 1 LRAALAAGLYPNVARRDPKGKGYTTLSdNQRVFIHPSSVLFnekTFPPEWVVYQELVETTKVYIRTVTAISPEWLLLFAP 80
|
..
gi 2755933196 698 HL 699
Cdd:pfam07717 81 HI 82
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
78-415 |
5.56e-12 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 70.39 E-value: 5.56e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 78 PVSQKKqdILEAIRDHQVVIVAGETGSGKTTQLPKICM---ELGRGIKGL-----------IGHTQPRRLAARTVANRIa 143
Cdd:PHA02653 166 PDVQLK--IFEAWISRKPVVLTGGTGVGKTSQVPKLLLwfnYLFGGFDNLdkidpnfierpIVLSLPRVALVRLHSITL- 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 144 eeLKTepggcIGYK--------VRFSDHVSDNTMVKLMTDGILLAeiqQDRL----LMQYDTIIIDEAHERSLNIDFLLG 211
Cdd:PHA02653 243 --LKS-----LGFDeidgspisLKYGSIPDELINTNPKPYGLVFS---THKLtlnkLFDYGTVIIDEVHEHDQIGDIIIA 312
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 212 YLKELLPRRPDLkiIITSATI--DPERFSRHFNNAPIIEVSGRT-YPV-EV----RYRPI--VEEADDTERDQLQAIFDA 281
Cdd:PHA02653 313 VARKHIDKIRSL--FLMTATLedDRDRIKEFFPNPAFVHIPGGTlFPIsEVyvknKYNPKnkRAYIEEEKKNIVTALKKY 390
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 282 VDElsQESPGdiLIFMSGEREIRDTADALnklnlrhTEILPLYA------RLSNSEQ--NRVfQSHSGRRIVLATNVAET 353
Cdd:PHA02653 391 TPP--KGSSG--IVFVASVSQCEEYKKYL-------EKRLPIYDfyiihgKVPNIDEilEKV-YSSKNPSIIISTPYLES 458
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2755933196 354 SLTVPGIKYVIDpgTARISRYSYRTKVQRLpiepISQASANQRKGRCGRVSEGICIRLYSED 415
Cdd:PHA02653 459 SVTIRNATHVYD--TGRVYVPEPFGGKEMF----ISKSMRTQRKGRVGRVSPGTYVYFYDLD 514
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
311-402 |
4.55e-11 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 59.92 E-value: 4.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 311 NKLNLRHTEILPLYARLSNSEQNRVFQS--HSGRRIVLATNVAETSLTVPGIKYVIDPGTarisrysyrtkvqrlpiePI 388
Cdd:smart00490 5 ELLKELGIKVARLHGGLSQEEREEILDKfnNGKIKVLVATDVAERGLDLPGVDLVIIYDL------------------PW 66
|
90
....*....|....
gi 2755933196 389 SQASANQRKGRCGR 402
Cdd:smart00490 67 SPASYIQRIGRAGR 80
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
282-403 |
3.51e-10 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 58.38 E-value: 3.51e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 282 VDELSQESPGDILIFMSGereiRDTADALNKLNLRHTEILPLYARLSNSEQNRVFQS--HSGRRIVLATNVAETSLTVPG 359
Cdd:pfam00271 7 LELLKKERGGKVLIFSQT----KKTLEAELLLEKEGIKVARLHGDLSQEEREEILEDfrKGKIDVLVATDVAERGLDLPD 82
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 2755933196 360 IKYVIDpgtarisrYSYrtkvqrlpiePISQASANQRKGRCGRV 403
Cdd:pfam00271 83 VDLVIN--------YDL----------PWNPASYIQRIGRAGRA 108
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
84-509 |
6.03e-10 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 63.38 E-value: 6.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 84 QDILEA-IRDHQVVIVAGETGSGKTT--QLPkICMELGRGIKGLIghtqprrLAA-RTVANRIAEELKT--EPGGcIGYK 157
Cdd:COG1204 28 AEALEAgLLEGKNLVVSAPTASGKTLiaELA-ILKALLNGGKALY-------IVPlRALASEKYREFKRdfEELG-IKVG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 158 VRFSDHVSDNTMVK-----LMT----DGILLAEIqqdRLLMQYDTIIIDEAH-----ERSLNIDFLLGYLKEllpRRPDL 223
Cdd:COG1204 99 VSTGDYDSDDEWLGrydilVATpeklDSLLRNGP---SWLRDVDLVVVDEAHliddeSRGPTLEVLLARLRR---LNPEA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 224 KIIITSATID-PERFSRHFnNAPIIEVSGRtyPVE----VRYRPIVEEADDTERDQLQAIFDAVDELSQEspGDILIFMS 298
Cdd:COG1204 173 QIVALSATIGnAEEIAEWL-DAELVKSDWR--PVPlnegVLYDGVLRFDDGSRRSKDPTLALALDLLEEG--GQVLVFVS 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 299 GEREIRDTADAL-NKLNLRHT-----EILPLYARLSNSEQ-------------NRVFQSHSG-----RRIV--------- 345
Cdd:COG1204 248 SRRDAESLAKKLaDELKRRLTpeereELEELAEELLEVSEethtnekladcleKGVAFHHAGlpselRRLVedafregli 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 346 ---LATnvaeTSLT----VPgIKYVIdpgtarISRYsYRTKVQRLPIEPISQASanqrkGRCGRVS-----EGICIRLYS 413
Cdd:COG1204 328 kvlVAT----PTLAagvnLP-ARRVI------IRDT-KRGGMVPIPVLEFKQMA-----GRAGRPGydpygEAILVAKSS 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 414 EDD-------FLSRPE-----FTDPEILRTNLASVILQMTTLGLGDIAAF--------PFVEAPDKRNIQDGVRLLEELG 473
Cdd:COG1204 391 DEAdelferyILGEPEpirskLANESALRTHLLALIASGFANSREELLDFlentfyayQYDKGDLEEVVDDALEFLLENG 470
|
490 500 510
....*....|....*....|....*....|....*.
gi 2755933196 474 AITtdEQASAYKLTPLGRQLSQLPVDPRLARMVLEA 509
Cdd:COG1204 471 FIE--EDGDRLRATKLGKLVSRLYIDPLTAAELVDG 504
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
84-235 |
1.22e-07 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 52.63 E-value: 1.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 84 QDILEAIRDHQVVIVAGETGSGKTT--QLP--KICMELGRGIKGLIghTQPRR-LAartvaNRIAEELKtEPGGCIGYKV 158
Cdd:pfam00270 5 AEAIPAILEGRDVLVQAPTGSGKTLafLLPalEALDKLDNGPQALV--LAPTReLA-----EQIYEELK-KLGKGLGLKV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 159 R--FSDHVSDNTMVKL-------MTDGILLAEIQQDRLLMQYDTIIIDEAHeRSLNIDF--LLGYLKELLPrrPDLKIII 227
Cdd:pfam00270 77 AslLGGDSRKEQLEKLkgpdilvGTPGRLLDLLQERKLLKNLKLLVLDEAH-RLLDMGFgpDLEEILRRLP--KKRQILL 153
|
....*...
gi 2755933196 228 TSATIDPE 235
Cdd:pfam00270 154 LSATLPRN 161
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
96-231 |
3.52e-05 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 45.09 E-value: 3.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 96 VIVAGETGSGKTT--QLPKICMELGRGIKGLIghTQPRrlaaRTVANRIAEELKTE--PGGCIGYKVRFSDhVSDNTMVK 171
Cdd:cd00046 4 VLITAPTGSGKTLaaLLAALLLLLKKGKKVLV--LVPT----KALALQTAERLRELfgPGIRVAVLVGGSS-AEEREKNK 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 172 LMTDGILLAEIQQDRLLMQ---------YDTIIIDEAHERSLNIDF-LLGYLKELLPRRPDLKIIITSAT 231
Cdd:cd00046 77 LGDADIIIATPDMLLNLLLredrlflkdLKLIIVDEAHALLIDSRGaLILDLAVRKAGLKNAQVILLSAT 146
|
|
| PRK01172 |
PRK01172 |
ATP-dependent DNA helicase; |
83-512 |
4.11e-05 |
|
ATP-dependent DNA helicase;
Pssm-ID: 100801 [Multi-domain] Cd Length: 674 Bit Score: 47.96 E-value: 4.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 83 KQDILEAIRDHQVVIVAGETGSGKT-TQLPKICMELGRGIKGLigHTQPrrlaARTVANRIAEELKTEPGgcIGYKVRFS 161
Cdd:PRK01172 27 QRMAIEQLRKGENVIVSVPTAAGKTlIAYSAIYETFLAGLKSI--YIVP----LRSLAMEKYEELSRLRS--LGMRVKIS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 162 --DHVSDNTMVKlMTDGILLAEIQQDRLlMQYD--------TIIIDEAH-----ERSLNIDFLLGYLKELlprRPDLKII 226
Cdd:PRK01172 99 igDYDDPPDFIK-RYDVVILTSEKADSL-IHHDpyiindvgLIVADEIHiigdeDRGPTLETVLSSARYV---NPDARIL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 227 ITSATIDPERFSRHFNNAPIIEVSGRTYPVEV----RYRPIVEEADDTERDQLQAIFDAVDElsqesPGDILIFMSGERE 302
Cdd:PRK01172 174 ALSATVSNANELAQWLNASLIKSNFRPVPLKLgilyRKRLILDGYERSQVDINSLIKETVND-----GGQVLVFVSSRKN 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 303 IRDTADALNKL-----NLRHT------------EILPL-----YARLSNSEQNRVFQSHSGRRI--VLATNVAETSLTVP 358
Cdd:PRK01172 249 AEDYAEMLIQHfpefnDFKVSsennnvyddslnEMLPHgvafhHAGLSNEQRRFIEEMFRNRYIkvIVATPTLAAGVNLP 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 359 GiKYVIdpgTARISRYSyrtkvqRLPIEPISQASANQRKGRCGRV---SEGICIrLYSED--------DFLS-RPEFTD- 425
Cdd:PRK01172 329 A-RLVI---VRDITRYG------NGGIRYLSNMEIKQMIGRAGRPgydQYGIGY-IYAASpasydaakKYLSgEPEPVIs 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 426 ----PEILRTNLASVILQMTTLGLGDIAAF---------PFVEAPDKRnIQDGVRLLEELGAIttdEQASAYKLTPLGRQ 492
Cdd:PRK01172 398 ymgsQRKVRFNTLAAISMGLASSMEDLILFynetlmaiqNGVDEIDYY-IESSLKFLKENGFI---KGDVTLRATRLGKL 473
|
490 500
....*....|....*....|
gi 2755933196 493 LSQLPVDPRLARMVLEAQKH 512
Cdd:PRK01172 474 TSDLYIDPESALILKSAFDH 493
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
95-412 |
6.24e-05 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 46.65 E-value: 6.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 95 VVIVAgETGSGKTT-QLPKICMELGRGIKGLIGHTQPRRLAARTVANRIAEELKTEPGGCIGYKVRFSDHVSDN------ 167
Cdd:cd09639 2 LVIEA-PTGYGKTEaALLWALHSLKSQKADRVIIALPTRATINAMYRRAKEAFGETGLYHSSILSSRIKEMGDSeefehl 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 168 ------TMVKLMTDGILLAEIQQ-----DRLLMQYDT---------IIIDEAH----ERSLNIDFLLGYLKELlprrpDL 223
Cdd:cd09639 81 fplyihSNDTLFLDPITVCTIDQvlksvFGEFGHYEFtlasianslLIFDEVHfydeYTLALILAVLEVLKDN-----DV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 224 KIIITSATIdPERFSRHF-NNAPIIEVSGRTY-PVEVRYRPIVEEADDTERDQLQAIFDAVDElsqesPGDILIFMSGER 301
Cdd:cd09639 156 PILLMSATL-PKFLKEYAeKIGYVEENEPLDLkPNERAPFIKIESDKVGEISSLERLLEFIKK-----GGSVAIIVNTVD 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 302 EIRDTADALNKLNlRHTEILPLYARLSNS------EQNRVFQSHSGRRIVLATNVAETSLTVPGIKYVIDPGtarisrys 375
Cdd:cd09639 230 RAQEFYQQLKEKG-PEEEIMLIHSRFTEKdrakkeAELLLEFKKSEKFVIVATQVIEASLDISVDVMITELA-------- 300
|
330 340 350
....*....|....*....|....*....|....*..
gi 2755933196 376 yrtkvqrlpiePISqaSANQRKGRCGRVSEGICIRLY 412
Cdd:cd09639 301 -----------PID--SLIQRLGRLHRYGEKNGEEVY 324
|
|
| cas3_core |
TIGR01587 |
CRISPR-associated helicase Cas3; This model represents the highly conserved core region of an ... |
95-407 |
8.05e-05 |
|
CRISPR-associated helicase Cas3; This model represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by pfam00270 (DEAD/DEAH box helicase) and pfam00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (pfam01966) that is not included within this model.
Pssm-ID: 273707 [Multi-domain] Cd Length: 359 Bit Score: 46.29 E-value: 8.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 95 VVIVAgETGSGKTT-QLPKICMELGRGIKGLIGHTQPRRLAARTVANRIAEELKTEPGGCIGYKV--RFSDHVSDNTMVK 171
Cdd:TIGR01587 2 LVIEA-PTGYGKTEaALLWALHSIKSQKADRVIIALPTRATINAMYRRAKELFGSELVGLHHSSSfsRIKEMGDSEEFEH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 172 LMT-----------DGILLAEIQQ-----DRLLMQYDT---------IIIDEAH----ERSLNIDFLLGYLKELlprrpD 222
Cdd:TIGR01587 81 LFPlyihsndklflDPITVCTIDQvlksvFGEFGHYEFtlasianslLIFDEVHfydeYTLALILAVLEVLKDN-----D 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 223 LKIIITSATIdPERFSRHF-NNAPIIEVSGRTYPVEVRYR----PIVEEADDTERDQLQAIFDAVDElsqesPGDILIFM 297
Cdd:TIGR01587 156 VPILLMSATL-PKFLKEYAeKIGYVEFNEPLDLKEERRFEnhrfILIESDKVGEISSLERLLEFIKK-----GGSIAIIV 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 298 SGEREIRDTADALNKLNlrHTEILPLY---------ARLSNSEQNRVFQSHSGRRIVlATNVAETSLTVPGIKYVIDPGt 368
Cdd:TIGR01587 230 NTVDRAQEFYQQLKEKA--PEEEIILYhsrftekdrAKKEAELLREMKKSNEKFVIV-ATQVIEASLDISADVMITELA- 305
|
330 340 350
....*....|....*....|....*....|....*....
gi 2755933196 369 arisrysyrtkvqrlpiePISqaSANQRKGRCGRVSEGI 407
Cdd:TIGR01587 306 ------------------PID--SLIQRLGRLHRYGRKI 324
|
|
| DEXHc_viral_Ns3 |
cd17931 |
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ... |
94-250 |
6.65e-04 |
|
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350689 [Multi-domain] Cd Length: 151 Bit Score: 41.77 E-value: 6.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 94 QVVIVAGETGSGKTTQ-LPKICMELGR-GIKGLIghtqprrLA-ARTVANRIAEELKTEPggcIGYK--VRFSDHvSDNT 168
Cdd:cd17931 2 QLTVLDLHPGAGKTTRvLPQIIREAIKkRLRTLV-------LApTRVVAAEMYEALRGLP---IRYRtgAVKEEH-GGNE 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 169 MVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLKELLpRRPDLKIIITSATIDPERFSRHFNNAPIIE 248
Cdd:cd17931 71 IVDYMCHGTFTCRLLSPKRVPNYNLIIMDEAHFTDPASIAARGYIHTRV-EMGEAAVIFMTATPPGTVTPFPQSNHPIED 149
|
..
gi 2755933196 249 VS 250
Cdd:cd17931 150 FE 151
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
84-364 |
2.07e-03 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 42.32 E-value: 2.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 84 QDILEAIRDH------QVVIVAGeTGSGKTTQLPKICMELGRGIKGLIghtqprrLAARTV-ANRIAEELKTEPGGCIGY 156
Cdd:COG1061 86 QEALEALLAAlergggRGLVVAP-TGTGKTVLALALAAELLRGKRVLV-------LVPRRElLEQWAEELRRFLGDPLAG 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 157 kvrfSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIdfllgyLKELLPRRPDLKIIITSATidPER 236
Cdd:COG1061 158 ----GGKKDSDAPITVATYQSLARRAHLDELGDRFGLVIIDEAHHAGAPS------YRRILEAFPAAYRLGLTAT--PFR 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 237 -------FSRHFN---NAPIIEVSGRTYPVEVRYRPI----------VEEADDTERDQL----QAIFDAVDELSQESPGD 292
Cdd:COG1061 226 sdgreilLFLFDGivyEYSLKEAIEDGYLAPPEYYGIrvdltderaeYDALSERLREALaadaERKDKILRELLREHPDD 305
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2755933196 293 --ILIFMSGEREIRDTADALNKLNLRhteILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVI 364
Cdd:COG1061 306 rkTLVFCSSVDHAEALAELLNEAGIR---AAVVTGDTPKKEREEILEafRDGELRILVTVDVLNEGVDVPRLDVAI 378
|
|
| DEAHc_XPD-like |
cd17915 |
DEAH-box helicase domain of XPD family DEAD-like helicases; The xeroderma pigmentosum group D ... |
102-247 |
6.42e-03 |
|
DEAH-box helicase domain of XPD family DEAD-like helicases; The xeroderma pigmentosum group D (XPD)-like family members are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350673 [Multi-domain] Cd Length: 138 Bit Score: 38.57 E-value: 6.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 102 TGSGKTTQLPKICMELGRGikgligHTQPRRL-AARTVAN--RIAEELKTEPGGcigYKVRFSDHVSDNTMVKLMTDGIL 178
Cdd:cd17915 10 TGSGKTLSLLCSALSYQRE------FHKTKVLyCSRTHSQieQIIRELRKLLEK---RKIRALALSSRDADIVVLPYPYL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2755933196 179 L-AEIQQ--DRLLMQYdTIIIDEAHerslNIDFLlgylkellprrpdlKIIITSATIDP-ERFSRHFNNAPII 247
Cdd:cd17915 81 LdARIREfiGIDLREQ-VVIIDEAH----NLDER--------------SVIITSGTLSPlDIYSKILGIRNML 134
|
|
| AAA |
smart00382 |
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
93-229 |
7.38e-03 |
|
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.
Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 38.51 E-value: 7.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2755933196 93 HQVVIVAGETGSGKTTQLPKICMELGRGIKGLIghtqprRLAARTVANRIAEELKTEPGGcigykvrfsdhvsdntMVKL 172
Cdd:smart00382 2 GEVILIVGPPGSGKTTLARALARELGPPGGGVI------YIDGEDILEEVLDQLLLIIVG----------------GKKA 59
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90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2755933196 173 MTDGILLAEIQQDRLL-MQYDTIIIDEAH------ERSLNIDFLLGYLKELLPRRPDLKIIITS 229
Cdd:smart00382 60 SGSGELRLRLALALARkLKPDVLILDEITslldaeQEALLLLLEELRLLLLLKSEKNLTVILTT 123
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