|
Name |
Accession |
Description |
Interval |
E-value |
| tegu_FGAM_synt |
TIGR01739 |
herpesvirus tegument protein/v-FGAM-synthase; This model describes a family of large proteins ... |
93-1290 |
0e+00 |
|
herpesvirus tegument protein/v-FGAM-synthase; This model describes a family of large proteins of herpesvirues. The protein is described variably as tegument protein or phosphoribosylformylglycinamidine synthase (FGAM-synthase). Most of the length of the protein shows homology to eukaryotic FGAM-synthase. Functional characterizations were not verified during construction of this model.
Pssm-ID: 273784 [Multi-domain] Cd Length: 1202 Bit Score: 1559.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 93 RVVSFGYGPNINHRPTTLSTELGVLLRELGLQEWARVEVGRHLVSKITQTLLEP---HPPQFIRAFTQNTDLVPYEGLEV 169
Cdd:TIGR01739 1 RTLDFMYGPNLQGRPTTFSRELVDLLGTLGLTYPIRVEIGRHLTFILTHELKDIakrHIELLYKFLCNKETLVTYLVIPQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 170 PE---------GPQPVARPHIEDDVIMQAVMISLGADLLPLAVQASTG-DNYNVARYFVIPGRCTMERWPWNCARQAFGI 239
Cdd:TIGR01739 81 DErfenfegsvGPPLVDPLPIPPDGLEQGIGYSSGGDRDLVAVAASVFaELDNVSIYPTAVDTWTSWDSTNMMYDTRETI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 240 HGAYTHVHSSV--QRGIRGLGNLLFHSTLFPGGQTQGALTGLYATEPALGPR-AHSRFRRIFAKGVQ-QAEMLQGAGVPT 315
Cdd:TIGR01739 161 EVGTGFLHANAniQPPGNQLENLRFLSSWLPGVMPVASQLGLYYQTPALTGEqDLPLSRKMSTAMLQaQASALRASGVPT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 316 LGGFLKTVRT---IATTPGNALAVCSISTTTSKECISLRRMIPQQTVVCLGRFEPTDGPDTYPNLYRDSSDNAVRILETL 392
Cdd:TIGR01739 241 CGGFIRLISKnklSLPTPYTPTYNTSILDRLCHVTINTADEPPGQDIVALGQFEPSLLPDTPPLLYADSPLDVNKILTAL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 393 KLVQRLAKGPIFSGLNRSHDPAPVVRHLQALAPRTGLELFVSKLPDEVRAHLPADPAAGPDAVEAAVAEHFLNVYCSLVF 472
Cdd:TIGR01739 321 ALLTDDVKTPCIVGSIRPLGPCSVKEHLTALLPPCGAELDLSNLPDEVVAALARSSPANRVENEKMVKQYFLNVVCSVVF 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 473 AVVAESGAVPGDLGETPLEVLQRAARLCACQITVLGRTSEQPGIRIVDDLTGETTRVFSVDQPSSTPPSPWLALSDGVRV 552
Cdd:TIGR01739 401 LTVKNTPHNTGTEGVTPLERLKTACRMFGCPVKVLGKLVPLPGLHIVSDLFNPVPTYPTFDFTSFTPTSPLLPLGGPEPV 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 553 S-----GHPEDVDWGLFATGSTIHQLLRHATVGSKEFFTRHMDRCSNGLIAQQAGVGPLDIPVSDYHLVLHSSmlaerva 627
Cdd:TIGR01739 481 SrtrpmFLDESLNWQTLNLRSTILKILSHPTVGSKEFIVRHIDRCGNGRVAQQQGVGPLDLPVSDYSLVLHNL------- 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 628 PRVPDTVEAITPSMANLLHKDFETWVKALPQELLPVPAWRGQAMAMGEQAYKMATNVSTGATYAITEALTNLMFSPVSKL 707
Cdd:TIGR01739 554 SRPTDTTEVTYSENAMDLILDPDSWLYSWENEVLENPALSCVCSALGEQTYKVQADPKRGATYAITEALLNLSLSPWNTL 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 708 QDVVLTGAVAWSPEDHQAGLLQECLFACKEFCRELGVALSISSAASSPTLSERHVritqqqetvevlPFNSVVFTSWAEV 787
Cdd:TIGR01739 634 EDVIITLSVTWSPTDHVYSLLKDALRACKDFCEELGVSFTVTSAASSPTQDSGSA------------PFMSIVFSASCPV 701
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 788 KGSRYRVTPDVKVEGNALVYLAVNQSCLIAGSTFEHNFLASRHPIPPLNPSTVASLFMLVKYLMSKRLIVSGHDIGDGGL 867
Cdd:TIGR01739 702 LLSAKKITPDLKSHGSHLIWLSLHPSYTLAGSIFEQILGLSFIRLPALSPVSLKKLLSALQTLVKEGVIVSGHDVSDGGL 781
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 868 LPSAIEMALAGCRGLQLSLPAHPNPLELMVSETPGALVEVPQVHLSEVLRAARDYRCVAHPLGTVGPEGQGNNVTVLQNE 947
Cdd:TIGR01739 782 VACVAEMALSGGKGVRITLPHGTDPLEFLCSETPGVVIEVDPSSMYAVLQFLRSEGLVFQVIGRVGESGPSPTFSVVHNS 861
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 948 TVVFQETLTSLQVSWTSFSDEMWNLVTPPLHPLEdMHRKDLGRLEHHLGSLRAMCLGSQLRLFSCPTSPRRVAALVLPGS 1027
Cdd:TIGR01739 862 TVLFQEPLSLLQGTWRSFSDEENTLLCPNLEPRE-MHVLDYGYNEMDFGGVPKGLPLSPLRFFTCPDPRHQVAVLLLPGQ 940
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 1028 SAPYALMAALQNTGFEVATVTVEELKRGQSLSGFSGLITCLRTGCQASYASARGWVLALCNDPTCASTLTEFLNRPDTFS 1107
Cdd:TIGR01739 941 SVPHGLLAALTNAGFDPRIVSITELKKTDFLDTFSGLIIGGASGTLDSEVGARALAAALLRNQAFLRDLLTFLNRPDTFS 1020
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 1108 ICCGEVGFQLLVALGVVGRSESSPYTYGPTPPQRwAVNLETNVSKLYDSHWLNIQIPQNTKSVFLRVLRGTVLPSWAQGE 1187
Cdd:TIGR01739 1021 LGFGELGCQLLLALNIVGYTQSSPFITVPTEVQE-PPRLEKNASGLYESRWLNFYIPETTKSVFLRPLRGSVLPCWAQGT 1099
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 1188 YLGVRYEQDALEYILRQRGEITLTYHGNAADETLPARHYPRNPTGNSTVAGLTSSDGRHAALIIDPSLMFHPWQWQHVPP 1267
Cdd:TIGR01739 1100 HLGLYHPDDGVEEELENSGQIASTFHGNSPSSGLPATNYPRNPSGGSNVAGLCSADGRHLALLIDPSLSFFPWQWQHVPP 1179
|
1210 1220
....*....|....*....|...
gi 2749266474 1268 DLTPLSMSPWAMAFQSIYLWSVK 1290
Cdd:TIGR01739 1180 NNPPLQVSPWKLMFQRLHLWSLA 1202
|
|
| PHA03366 |
PHA03366 |
FGAM-synthase; Provisional |
1-1293 |
0e+00 |
|
FGAM-synthase; Provisional
Pssm-ID: 223058 [Multi-domain] Cd Length: 1304 Bit Score: 1558.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 1 MAYDVTGLWLESDLTADEEAFVSFYTSRTGTLTLVPGGTGGYYLLWITFRRPPTSREERERRDVEIQTVLAVLSPLLGYP 80
Cdd:PHA03366 4 PFQLTLLFFADADLSPEEERLVALLLDRPGPLTLISGPLQSEHLLLVTVRGSASDPRPRRQRREELALILALLSPLLEYT 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 81 HVIRRSPPRGSERVVSFGYGPNINHRPTTLSTELGVLLRELGLQEWARVEVGRHLVSKITQTLLEPHPPQFIRAFTQNTD 160
Cdd:PHA03366 84 PLTTESRGKGGSRTLSFSYGPDLNRRPTTFSRELVALLQTLGLREVLRIELGRHLTFKLLQSPLEHHMDQLLEALLLPDS 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 161 LVPY--EGLEV------PEGPQPVARP-HIEDDVIMQAVM--ISLGADLLPLAVQASTG-DNYNVARYFVIPGRCTMERw 228
Cdd:PHA03366 164 LLRPyiEGQESrglvtaPLAPPALTAPlSDPLDKVCNGVMgdLPLGGDALPVAIQASSPlPGYTVAYYLSLTPTCTSVR- 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 229 PWNCARQAFGIHGAYTHVHSSVQRGIRGLGNLLFHSTLFPGGQTQGALTGLYATEPAL-GPRAHSRFRRIFAKGVQQAEM 307
Cdd:PHA03366 243 SNYLTRGAHSVETGFLHTHGSIQTMGPQLTGLLFQPSLLPGGLPRASALGWYVTTPSGgGPLSPLAPRQIAETLEAQARS 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 308 LQGAGVPTLGGFLKTVRT----IATTPGNALAVCSISTTTSKECISLRRMIPQQTVVCLGRFEPTDGPDTYPNLYRDSSD 383
Cdd:PHA03366 323 LNCSGVPVVGGFLRTIPTtlalISPLPNNMLTFTSLLSTISTIALDTARYRPGQYIVALGSFEPSSGPDTPPYLYRDSGL 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 384 NAVRILETLKLVQRLAKGPIFSGLNRSHDPAPVVRHLQALAPRTGLELFVSKLPDEVRAHLPADPAAGPDAVEAAVAEHF 463
Cdd:PHA03366 403 EANKILQALKLFYSLLPGPCISGSSRPLGPASVLEHLLALCPPGGLLLFLSALPEDVVSGLKPFSASNRETNEEIVKQYF 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 464 LNVYCSLVFAVVAESGavPGDLGETPLEVLQRAARLCACQITVLGRTSEQPGIRIVDDLTGETTRVFSVDQPSSTPPSPW 543
Cdd:PHA03366 483 LNVYCSVVFLVIKNTH--EGGEGVTPLDALKRACRLAGCPVHILGRTVPLPGIHFVNDLGNPVYGELRDDQFKPTFPLQP 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 544 L-------ALSDGVRVSGHPEDVDWGLFATGSTIHQLLRHATVGSKEFFTRHMDRCSNGLIAQQAGVGPLDIPVSDYHLV 616
Cdd:PHA03366 561 SrplspvsATSEDTRPSPQDESIDWALFNLNSTLLQILSHPTVGSKEYIVRHIDRCGNGRVAQQPGVGPLDLPVSDYSIV 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 617 LHSSMLAERVaPRVPDTVEAITPSMANLLHKDFETWVKALPQELLPvPAWRGQAMAMGEQAYKMATNVSTGATYAITEAL 696
Cdd:PHA03366 641 VHSSVKTRRA-IETPSSTEDLTYQEADELINSPLTWFDPDDESVLH-PAVPGTCSALGEQGYKVQLDPILGAKYAIVEAL 718
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 697 TNLMFSPVSKLQDVVLTGAVAWSPEDHQAGLLQECLFACKEFCRELGVALSISSAASSPTlserhvritQQQETVEVLPF 776
Cdd:PHA03366 719 TNLMLAPVANLEDITITLSVTWPPTDQAASELYRALAACKEFCRELGVNFTFTSASSSPR---------QDQPPQPGPLF 789
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 777 NSVVFTSWAEVKGSRYRVTPDVKVEGNALVYLAVNQSCLIAGSTFEHNFLASRHPIPPLNPSTVASLFMLVKYLMSKRLI 856
Cdd:PHA03366 790 NTIVFTASAPVPSSTPRLTPDLKKPGSALVHLSISPEYTLAGSVFEQIFGLKSGTLPDISPSYLKNLFRAVQHLISEGLV 869
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 857 VSGHDIGDGGLLPSAIEMALAGCRGLQLSLPAHPNPLELMVSETPGALVEVPQVHLSEVLRAARDYRCVAHPLGTVGPEG 936
Cdd:PHA03366 870 VSGHDVSDGGLIACLAEMALAGGRGVTITVPAGEDPLQFLFSETPGVVIEVPPSHLSAVLTRLRSRNIICYPIGTVGPSG 949
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 937 QGNNVTVLQNETVVFQETLTSLQVSWTSFSDEMWNLVTPPLHpLEDMHRKDLGRLEHHLGSLRAMCLGSQLRLFSCPTSP 1016
Cdd:PHA03366 950 PSNTFSVSHNGTVLFRESLSSLRSTWRSFSDEQFELLRPDLT-EESMYRKDYGNNEVDLGPLEEGLTTSPLRLYTCPDKR 1028
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 1017 RRVAALVLPGSSAPYALMAALQNTGFEVATVTVEELKRGQSLSGFSGLITCLRTGCQASYASARGWVLALCNDPTCASTL 1096
Cdd:PHA03366 1029 HRVAVLLLPGCPGPHALLAAFTNAGFDPYPVSIEELKDGTFLDEFSGLVIGGSSGAEDSYTGARAAVAALLSNPAVRDAL 1108
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 1097 TEFLNRPDTFSICCGEVGFQLLVALGVVGRSESSPYTYGPTPPQrWAVNLETNVSKLYDSHWLNIQIPQNTKSVFLRVLR 1176
Cdd:PHA03366 1109 LRFLNRPDTFSLGCGELGCQILFALKAVGSTAPSPVPGTETEEQ-WPITLEPNASGLYESRWLNFYIPETTKSVALRPLR 1187
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 1177 GTVLPSWAQGEYLGVRYEQDALEYILRQRGEITLTYHGNAADETLPARHYPRNPTGNSTVAGLTSSDGRHAALIIDPSLM 1256
Cdd:PHA03366 1188 GSVLPCWAQGTHLGFRYPNDGMEYILRNSGQIAATFHGADVDPGNPARHYPRNPTGNSNVAGLCSADGRHLALLFDPSLS 1267
|
1290 1300 1310
....*....|....*....|....*....|....*..
gi 2749266474 1257 FHPWQWQHVPPDLTPLSMSPWAMAFQSIYLWSVKKIN 1293
Cdd:PHA03366 1268 FHPWQWQHVPPENGPLKVSPWKLMFQDLHLWCLKHRH 1304
|
|
| Tegument_dsDNA |
pfam12818 |
dsDNA viral tegument protein; This is a family of tegument proteins from double-stranded DNA ... |
239-516 |
9.45e-141 |
|
dsDNA viral tegument protein; This is a family of tegument proteins from double-stranded DNA herpesvirus and related viral species.
Pssm-ID: 289579 Cd Length: 277 Bit Score: 429.18 E-value: 9.45e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 239 IHGAYTHVHSSVQRGIRGLGNLLFHSTLFPGGQTQGALTGLYATEPAL-GPRAHSRFRRIFAKGVQQAEMLQGAGVPTLG 317
Cdd:pfam12818 1 VHYAITHVHSSLQFMGQQLDGLRFHSSLLPFGNTLASALGAYVTTPAGnGRQAYAVMRRIYASLMAQAECLNRAGVPVVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 318 GFLKTVRTIATTPGNALAVCSISTTTSKECISLRRMIPQQTVVCLGRFEPTDGPDTYPNLYRDSSDNAVRILETLKLVQR 397
Cdd:pfam12818 81 GFLRTICTNATLKGNPLLYESHLATSSGSNLKTARFRPGQYLVALGQFYPTSGPDTPPYLYRDSSDDYNRVVQALNLFYC 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 398 LAKGPIFSGLNRSHDPAPVVRHLQALAPRTGLELFVSKLPDEVRAHLPADPAAGPDAVEAAVAEHFLNVYCSLVFAVVAE 477
Cdd:pfam12818 161 TVTSPCVSGYLRDLGPASVKQHLGALLPRGGANLYISKLPDEVVYQLRRIPATEEDSLEALVSVYFLNVYCSQVFLVVKD 240
|
250 260 270
....*....|....*....|....*....|....*....
gi 2749266474 478 SGAVPGdlGETPLEVLQRAARLCACQITVLGRTSEQPGI 516
Cdd:pfam12818 241 TGEKIG--GTTPLEILQRAARLCGCQVYVLGRTVDQIGI 277
|
|
| PurL1 |
COG0046 |
Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and ... |
493-964 |
6.43e-35 |
|
Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain is part of the Pathway/BioSystem: Purine biosynthesis
Pssm-ID: 439816 [Multi-domain] Cd Length: 747 Bit Score: 144.04 E-value: 6.43e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 493 LQRAARLCA---CQITVLGRTSEQPGIRI-----------VDDLTGETtrvfsvdqPSSTPPSPWLALSDGVRVsghPED 558
Cdd:COG0046 334 LEEFEAIFErwrLPAAVIGEVTDDGRLVVtdhgetvadlpLDFLAGGA--------PKYHRPAKRPAYLEPLDL---PEP 402
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 559 VDWGlfatgSTIHQLLRHATVGSKEFFTRHMDRCSNGLIAqqagVGPldiPVSDyhlvlhSSMLaervapRVPDTveait 638
Cdd:COG0046 403 IDLE-----EALLRLLSSPNVASKEWLYRQYDREVGGNTV----RDP---GVAD------AAVV------RVDGT----- 453
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 639 psmanllhkdfetwvkalpqellpvpaWRGQAMAMGEQAYKMATNVSTGATYAITEALTNLMFSPVSKLqDVVLT---Ga 715
Cdd:COG0046 454 ---------------------------YKGLAMSTGENPRYALLDPYAGARMAVAEAARNLAAVGAEPL-AITDClnwG- 504
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 716 vawSPED-HQAGLLQECLFACKEFCRELGValsissaassPtlserhvrIT---------QQQETVEVLPfnSVVFTSWA 785
Cdd:COG0046 505 ---NPEKpEEMAQLVEAVKGLADACRALGI----------P--------VPsgnvslyneTKDGKVAIPP--TPVIGAVG 561
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 786 EVKGSRYRVTPDVKVEGNALVYLAVNQSCLiAGSTF--EHNFLASRhpIPPLNPSTVASLFMLVKYLMSKRLIVSGHDIG 863
Cdd:COG0046 562 LVDDVRKTVTPDLKKEGDLLYLIGETKNEL-GGSEYaqVLGQLGGE--PPDVDLEAEKALFEAVQELIREGLILAAHDVS 638
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 864 DGGLLPSAIEMALAGCRGLQLSLPAHPN--PLELMVSETPG-ALVEVPQVHLSEVLRAARDYRCVAHPLGTVGPEGQgnn 940
Cdd:COG0046 639 DGGLAVALAEMAFAGGLGADIDLDALGDlrPDAALFSESQGrAVVQVAPEDAEAVEALLAEAGLPAHVIGTVTGDDR--- 715
|
490 500
....*....|....*....|....
gi 2749266474 941 VTVLQNETVVFQETLTSLQVSWTS 964
Cdd:COG0046 716 LVIRRGGETLLSLSLAELRDAWEE 739
|
|
| PurL_repeat2 |
cd02204 |
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. ... |
661-932 |
2.12e-26 |
|
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100035 [Multi-domain] Cd Length: 264 Bit Score: 109.93 E-value: 2.12e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 661 LPVPAWRGQAMAMGEQAYKMATNVSTGATYAITEALTNLMFSPVSKLqDVVLTGAVAWsPEDHQA--GLLQECLFACKEF 738
Cdd:cd02204 7 IPGETDKGLAMSTGENPRYSLLDPYAGAALAVAEAVRNLVAVGADPL-AITDCLNFGN-PEKPEGemGQLVEAVLGLGDA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 739 CRELGValsissaassP------TLSerhvritQQQETVEVLPfnSVVFTSWAEVKGSRYRVTPDVKVEGNALVYLAVNQ 812
Cdd:cd02204 85 CRALGT----------PviggkdSLY-------NETEGVAIPP--TLVIGAVGVVDDVRKIVTLDFKKEGDLLYLIGETK 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 813 SCLIAGSTFEHNFLASRHPIPPLNPSTVASLFMLVKYLMSKRLIVSGHDIGDGGLLPSAIEMALAGCRGLQLSLPAHPNP 892
Cdd:cd02204 146 DELGGSEYALAYHGLGGGAPPLVDLEREKALFDAVQELIKEGLVLSAHDVSDGGLAVALAEMAFAGGLGAEVDLSKDDAE 225
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 2749266474 893 LELMVSETPGA-LVEVPQVHLSEVLRAARDYRCvaHPLGTV 932
Cdd:cd02204 226 DELLFSESLGRvLVEVKPENEEVFEAEEAGVPA--TVIGTV 264
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| tegu_FGAM_synt |
TIGR01739 |
herpesvirus tegument protein/v-FGAM-synthase; This model describes a family of large proteins ... |
93-1290 |
0e+00 |
|
herpesvirus tegument protein/v-FGAM-synthase; This model describes a family of large proteins of herpesvirues. The protein is described variably as tegument protein or phosphoribosylformylglycinamidine synthase (FGAM-synthase). Most of the length of the protein shows homology to eukaryotic FGAM-synthase. Functional characterizations were not verified during construction of this model.
Pssm-ID: 273784 [Multi-domain] Cd Length: 1202 Bit Score: 1559.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 93 RVVSFGYGPNINHRPTTLSTELGVLLRELGLQEWARVEVGRHLVSKITQTLLEP---HPPQFIRAFTQNTDLVPYEGLEV 169
Cdd:TIGR01739 1 RTLDFMYGPNLQGRPTTFSRELVDLLGTLGLTYPIRVEIGRHLTFILTHELKDIakrHIELLYKFLCNKETLVTYLVIPQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 170 PE---------GPQPVARPHIEDDVIMQAVMISLGADLLPLAVQASTG-DNYNVARYFVIPGRCTMERWPWNCARQAFGI 239
Cdd:TIGR01739 81 DErfenfegsvGPPLVDPLPIPPDGLEQGIGYSSGGDRDLVAVAASVFaELDNVSIYPTAVDTWTSWDSTNMMYDTRETI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 240 HGAYTHVHSSV--QRGIRGLGNLLFHSTLFPGGQTQGALTGLYATEPALGPR-AHSRFRRIFAKGVQ-QAEMLQGAGVPT 315
Cdd:TIGR01739 161 EVGTGFLHANAniQPPGNQLENLRFLSSWLPGVMPVASQLGLYYQTPALTGEqDLPLSRKMSTAMLQaQASALRASGVPT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 316 LGGFLKTVRT---IATTPGNALAVCSISTTTSKECISLRRMIPQQTVVCLGRFEPTDGPDTYPNLYRDSSDNAVRILETL 392
Cdd:TIGR01739 241 CGGFIRLISKnklSLPTPYTPTYNTSILDRLCHVTINTADEPPGQDIVALGQFEPSLLPDTPPLLYADSPLDVNKILTAL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 393 KLVQRLAKGPIFSGLNRSHDPAPVVRHLQALAPRTGLELFVSKLPDEVRAHLPADPAAGPDAVEAAVAEHFLNVYCSLVF 472
Cdd:TIGR01739 321 ALLTDDVKTPCIVGSIRPLGPCSVKEHLTALLPPCGAELDLSNLPDEVVAALARSSPANRVENEKMVKQYFLNVVCSVVF 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 473 AVVAESGAVPGDLGETPLEVLQRAARLCACQITVLGRTSEQPGIRIVDDLTGETTRVFSVDQPSSTPPSPWLALSDGVRV 552
Cdd:TIGR01739 401 LTVKNTPHNTGTEGVTPLERLKTACRMFGCPVKVLGKLVPLPGLHIVSDLFNPVPTYPTFDFTSFTPTSPLLPLGGPEPV 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 553 S-----GHPEDVDWGLFATGSTIHQLLRHATVGSKEFFTRHMDRCSNGLIAQQAGVGPLDIPVSDYHLVLHSSmlaerva 627
Cdd:TIGR01739 481 SrtrpmFLDESLNWQTLNLRSTILKILSHPTVGSKEFIVRHIDRCGNGRVAQQQGVGPLDLPVSDYSLVLHNL------- 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 628 PRVPDTVEAITPSMANLLHKDFETWVKALPQELLPVPAWRGQAMAMGEQAYKMATNVSTGATYAITEALTNLMFSPVSKL 707
Cdd:TIGR01739 554 SRPTDTTEVTYSENAMDLILDPDSWLYSWENEVLENPALSCVCSALGEQTYKVQADPKRGATYAITEALLNLSLSPWNTL 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 708 QDVVLTGAVAWSPEDHQAGLLQECLFACKEFCRELGVALSISSAASSPTLSERHVritqqqetvevlPFNSVVFTSWAEV 787
Cdd:TIGR01739 634 EDVIITLSVTWSPTDHVYSLLKDALRACKDFCEELGVSFTVTSAASSPTQDSGSA------------PFMSIVFSASCPV 701
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 788 KGSRYRVTPDVKVEGNALVYLAVNQSCLIAGSTFEHNFLASRHPIPPLNPSTVASLFMLVKYLMSKRLIVSGHDIGDGGL 867
Cdd:TIGR01739 702 LLSAKKITPDLKSHGSHLIWLSLHPSYTLAGSIFEQILGLSFIRLPALSPVSLKKLLSALQTLVKEGVIVSGHDVSDGGL 781
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 868 LPSAIEMALAGCRGLQLSLPAHPNPLELMVSETPGALVEVPQVHLSEVLRAARDYRCVAHPLGTVGPEGQGNNVTVLQNE 947
Cdd:TIGR01739 782 VACVAEMALSGGKGVRITLPHGTDPLEFLCSETPGVVIEVDPSSMYAVLQFLRSEGLVFQVIGRVGESGPSPTFSVVHNS 861
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 948 TVVFQETLTSLQVSWTSFSDEMWNLVTPPLHPLEdMHRKDLGRLEHHLGSLRAMCLGSQLRLFSCPTSPRRVAALVLPGS 1027
Cdd:TIGR01739 862 TVLFQEPLSLLQGTWRSFSDEENTLLCPNLEPRE-MHVLDYGYNEMDFGGVPKGLPLSPLRFFTCPDPRHQVAVLLLPGQ 940
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 1028 SAPYALMAALQNTGFEVATVTVEELKRGQSLSGFSGLITCLRTGCQASYASARGWVLALCNDPTCASTLTEFLNRPDTFS 1107
Cdd:TIGR01739 941 SVPHGLLAALTNAGFDPRIVSITELKKTDFLDTFSGLIIGGASGTLDSEVGARALAAALLRNQAFLRDLLTFLNRPDTFS 1020
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 1108 ICCGEVGFQLLVALGVVGRSESSPYTYGPTPPQRwAVNLETNVSKLYDSHWLNIQIPQNTKSVFLRVLRGTVLPSWAQGE 1187
Cdd:TIGR01739 1021 LGFGELGCQLLLALNIVGYTQSSPFITVPTEVQE-PPRLEKNASGLYESRWLNFYIPETTKSVFLRPLRGSVLPCWAQGT 1099
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 1188 YLGVRYEQDALEYILRQRGEITLTYHGNAADETLPARHYPRNPTGNSTVAGLTSSDGRHAALIIDPSLMFHPWQWQHVPP 1267
Cdd:TIGR01739 1100 HLGLYHPDDGVEEELENSGQIASTFHGNSPSSGLPATNYPRNPSGGSNVAGLCSADGRHLALLIDPSLSFFPWQWQHVPP 1179
|
1210 1220
....*....|....*....|...
gi 2749266474 1268 DLTPLSMSPWAMAFQSIYLWSVK 1290
Cdd:TIGR01739 1180 NNPPLQVSPWKLMFQRLHLWSLA 1202
|
|
| PHA03366 |
PHA03366 |
FGAM-synthase; Provisional |
1-1293 |
0e+00 |
|
FGAM-synthase; Provisional
Pssm-ID: 223058 [Multi-domain] Cd Length: 1304 Bit Score: 1558.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 1 MAYDVTGLWLESDLTADEEAFVSFYTSRTGTLTLVPGGTGGYYLLWITFRRPPTSREERERRDVEIQTVLAVLSPLLGYP 80
Cdd:PHA03366 4 PFQLTLLFFADADLSPEEERLVALLLDRPGPLTLISGPLQSEHLLLVTVRGSASDPRPRRQRREELALILALLSPLLEYT 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 81 HVIRRSPPRGSERVVSFGYGPNINHRPTTLSTELGVLLRELGLQEWARVEVGRHLVSKITQTLLEPHPPQFIRAFTQNTD 160
Cdd:PHA03366 84 PLTTESRGKGGSRTLSFSYGPDLNRRPTTFSRELVALLQTLGLREVLRIELGRHLTFKLLQSPLEHHMDQLLEALLLPDS 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 161 LVPY--EGLEV------PEGPQPVARP-HIEDDVIMQAVM--ISLGADLLPLAVQASTG-DNYNVARYFVIPGRCTMERw 228
Cdd:PHA03366 164 LLRPyiEGQESrglvtaPLAPPALTAPlSDPLDKVCNGVMgdLPLGGDALPVAIQASSPlPGYTVAYYLSLTPTCTSVR- 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 229 PWNCARQAFGIHGAYTHVHSSVQRGIRGLGNLLFHSTLFPGGQTQGALTGLYATEPAL-GPRAHSRFRRIFAKGVQQAEM 307
Cdd:PHA03366 243 SNYLTRGAHSVETGFLHTHGSIQTMGPQLTGLLFQPSLLPGGLPRASALGWYVTTPSGgGPLSPLAPRQIAETLEAQARS 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 308 LQGAGVPTLGGFLKTVRT----IATTPGNALAVCSISTTTSKECISLRRMIPQQTVVCLGRFEPTDGPDTYPNLYRDSSD 383
Cdd:PHA03366 323 LNCSGVPVVGGFLRTIPTtlalISPLPNNMLTFTSLLSTISTIALDTARYRPGQYIVALGSFEPSSGPDTPPYLYRDSGL 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 384 NAVRILETLKLVQRLAKGPIFSGLNRSHDPAPVVRHLQALAPRTGLELFVSKLPDEVRAHLPADPAAGPDAVEAAVAEHF 463
Cdd:PHA03366 403 EANKILQALKLFYSLLPGPCISGSSRPLGPASVLEHLLALCPPGGLLLFLSALPEDVVSGLKPFSASNRETNEEIVKQYF 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 464 LNVYCSLVFAVVAESGavPGDLGETPLEVLQRAARLCACQITVLGRTSEQPGIRIVDDLTGETTRVFSVDQPSSTPPSPW 543
Cdd:PHA03366 483 LNVYCSVVFLVIKNTH--EGGEGVTPLDALKRACRLAGCPVHILGRTVPLPGIHFVNDLGNPVYGELRDDQFKPTFPLQP 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 544 L-------ALSDGVRVSGHPEDVDWGLFATGSTIHQLLRHATVGSKEFFTRHMDRCSNGLIAQQAGVGPLDIPVSDYHLV 616
Cdd:PHA03366 561 SrplspvsATSEDTRPSPQDESIDWALFNLNSTLLQILSHPTVGSKEYIVRHIDRCGNGRVAQQPGVGPLDLPVSDYSIV 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 617 LHSSMLAERVaPRVPDTVEAITPSMANLLHKDFETWVKALPQELLPvPAWRGQAMAMGEQAYKMATNVSTGATYAITEAL 696
Cdd:PHA03366 641 VHSSVKTRRA-IETPSSTEDLTYQEADELINSPLTWFDPDDESVLH-PAVPGTCSALGEQGYKVQLDPILGAKYAIVEAL 718
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 697 TNLMFSPVSKLQDVVLTGAVAWSPEDHQAGLLQECLFACKEFCRELGVALSISSAASSPTlserhvritQQQETVEVLPF 776
Cdd:PHA03366 719 TNLMLAPVANLEDITITLSVTWPPTDQAASELYRALAACKEFCRELGVNFTFTSASSSPR---------QDQPPQPGPLF 789
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 777 NSVVFTSWAEVKGSRYRVTPDVKVEGNALVYLAVNQSCLIAGSTFEHNFLASRHPIPPLNPSTVASLFMLVKYLMSKRLI 856
Cdd:PHA03366 790 NTIVFTASAPVPSSTPRLTPDLKKPGSALVHLSISPEYTLAGSVFEQIFGLKSGTLPDISPSYLKNLFRAVQHLISEGLV 869
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 857 VSGHDIGDGGLLPSAIEMALAGCRGLQLSLPAHPNPLELMVSETPGALVEVPQVHLSEVLRAARDYRCVAHPLGTVGPEG 936
Cdd:PHA03366 870 VSGHDVSDGGLIACLAEMALAGGRGVTITVPAGEDPLQFLFSETPGVVIEVPPSHLSAVLTRLRSRNIICYPIGTVGPSG 949
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 937 QGNNVTVLQNETVVFQETLTSLQVSWTSFSDEMWNLVTPPLHpLEDMHRKDLGRLEHHLGSLRAMCLGSQLRLFSCPTSP 1016
Cdd:PHA03366 950 PSNTFSVSHNGTVLFRESLSSLRSTWRSFSDEQFELLRPDLT-EESMYRKDYGNNEVDLGPLEEGLTTSPLRLYTCPDKR 1028
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 1017 RRVAALVLPGSSAPYALMAALQNTGFEVATVTVEELKRGQSLSGFSGLITCLRTGCQASYASARGWVLALCNDPTCASTL 1096
Cdd:PHA03366 1029 HRVAVLLLPGCPGPHALLAAFTNAGFDPYPVSIEELKDGTFLDEFSGLVIGGSSGAEDSYTGARAAVAALLSNPAVRDAL 1108
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 1097 TEFLNRPDTFSICCGEVGFQLLVALGVVGRSESSPYTYGPTPPQrWAVNLETNVSKLYDSHWLNIQIPQNTKSVFLRVLR 1176
Cdd:PHA03366 1109 LRFLNRPDTFSLGCGELGCQILFALKAVGSTAPSPVPGTETEEQ-WPITLEPNASGLYESRWLNFYIPETTKSVALRPLR 1187
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 1177 GTVLPSWAQGEYLGVRYEQDALEYILRQRGEITLTYHGNAADETLPARHYPRNPTGNSTVAGLTSSDGRHAALIIDPSLM 1256
Cdd:PHA03366 1188 GSVLPCWAQGTHLGFRYPNDGMEYILRNSGQIAATFHGADVDPGNPARHYPRNPTGNSNVAGLCSADGRHLALLFDPSLS 1267
|
1290 1300 1310
....*....|....*....|....*....|....*..
gi 2749266474 1257 FHPWQWQHVPPDLTPLSMSPWAMAFQSIYLWSVKKIN 1293
Cdd:PHA03366 1268 FHPWQWQHVPPENGPLKVSPWKLMFQDLHLWCLKHRH 1304
|
|
| Tegument_dsDNA |
pfam12818 |
dsDNA viral tegument protein; This is a family of tegument proteins from double-stranded DNA ... |
239-516 |
9.45e-141 |
|
dsDNA viral tegument protein; This is a family of tegument proteins from double-stranded DNA herpesvirus and related viral species.
Pssm-ID: 289579 Cd Length: 277 Bit Score: 429.18 E-value: 9.45e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 239 IHGAYTHVHSSVQRGIRGLGNLLFHSTLFPGGQTQGALTGLYATEPAL-GPRAHSRFRRIFAKGVQQAEMLQGAGVPTLG 317
Cdd:pfam12818 1 VHYAITHVHSSLQFMGQQLDGLRFHSSLLPFGNTLASALGAYVTTPAGnGRQAYAVMRRIYASLMAQAECLNRAGVPVVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 318 GFLKTVRTIATTPGNALAVCSISTTTSKECISLRRMIPQQTVVCLGRFEPTDGPDTYPNLYRDSSDNAVRILETLKLVQR 397
Cdd:pfam12818 81 GFLRTICTNATLKGNPLLYESHLATSSGSNLKTARFRPGQYLVALGQFYPTSGPDTPPYLYRDSSDDYNRVVQALNLFYC 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 398 LAKGPIFSGLNRSHDPAPVVRHLQALAPRTGLELFVSKLPDEVRAHLPADPAAGPDAVEAAVAEHFLNVYCSLVFAVVAE 477
Cdd:pfam12818 161 TVTSPCVSGYLRDLGPASVKQHLGALLPRGGANLYISKLPDEVVYQLRRIPATEEDSLEALVSVYFLNVYCSQVFLVVKD 240
|
250 260 270
....*....|....*....|....*....|....*....
gi 2749266474 478 SGAVPGdlGETPLEVLQRAARLCACQITVLGRTSEQPGI 516
Cdd:pfam12818 241 TGEKIG--GTTPLEILQRAARLCGCQVYVLGRTVDQIGI 277
|
|
| GATase_5 |
pfam13507 |
CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not ... |
1018-1287 |
6.89e-52 |
|
CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not found in pfam00310, pfam07685 and pfam13230.
Pssm-ID: 463904 [Multi-domain] Cd Length: 260 Bit Score: 183.47 E-value: 6.89e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 1018 RVAALVLPGSSAPYALMAALQNTGFEVATVTVEELKRGQ-SLSGFSGLITClrTGcqASYA----SARGWVLALCNDPTC 1092
Cdd:pfam13507 3 RVAILREPGTNGEYEMAAAFERAGFDAVDVHMSDLLSGRvSLDDFQGLAAP--GG--FSYGdvlgSGKGWAASILFNPKL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 1093 ASTLTEFLNRPDTFSICCGEvGFQLLVALGVVgrsessPYTyGPTPPQRWaVNLETNVSKLYDSHWLNIQIPQNTKSVFL 1172
Cdd:pfam13507 79 RDAFEAFFNRPDTFSLGICN-GCQLLSKLGLI------PGG-EGDLAERW-PTLTRNDSGRFESRWVNVKISEKSPSVFL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 1173 RVLRGTVLPsWAQGEyLGVRYEQDALEYILRQRGEITLTYHGNAADetlPARHYPRNPTGnST--VAGLTSSDGRHAALI 1250
Cdd:pfam13507 150 RGMDGSGLP-VAHGE-GRFVFRSEEVLARLEANGQVALRYVDNAGN---PTEEYPFNPNG-SPlgIAGICSPDGRVLGLM 223
|
250 260 270
....*....|....*....|....*....|....*..
gi 2749266474 1251 IDPSLMFHPWQWQHVPPDLTPlSMSPWAMAFQSIYLW 1287
Cdd:pfam13507 224 PHPERVFRPWQWPHWPPGEWE-EVSPWLRLFRNARKW 259
|
|
| PLN03206 |
PLN03206 |
phosphoribosylformylglycinamidine synthase; Provisional |
567-1287 |
3.03e-51 |
|
phosphoribosylformylglycinamidine synthase; Provisional
Pssm-ID: 178745 [Multi-domain] Cd Length: 1307 Bit Score: 198.45 E-value: 3.03e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 567 GSTIHQLLRHATVGSKEFFTRHMDRCSNGLIAQQAGVGPLDIPVSDYHLVLHSsmlaervaprvpdtveaitpsmanllH 646
Cdd:PLN03206 641 MDALKRVLRLPSVCSKRFLTTKVDRCVTGLVAQQQTVGPLQIPLADVAVIAQT--------------------------H 694
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 647 KDFEtwvkalpqellpvpawrGQAMAMGEQAYKMATNVSTGATYAITEALTNLMFSPVSKLQDVVLTG--AVAWSPEDHQ 724
Cdd:PLN03206 695 TGLT-----------------GGACAIGEQPIKGLVDPKAMARLAVGEALTNLVWAKVTALSDVKASGnwMYAAKLDGEG 757
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 725 AGLLQECLfACKEFCRELGVALSISSAasspTLSerhVRITQQQETVEVlPFNsVVFTSWAEVKGSRYRVTPDVKVEGNA 804
Cdd:PLN03206 758 ADMYDAAV-ALRDAMIELGVAIDGGKD----SLS---MAAQAGGEVVKA-PGN-LVISAYVTCPDITKTVTPDLKLGDDG 827
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 805 ---LVYLAVNQSCLiAGSTFEHNFLASRHPIPPL-NPSTVASLFMLVKYLMSKRLIVSGHDIGDGGLLPSAIEMALAGCR 880
Cdd:PLN03206 828 vllHVDLGKGKRRL-GGSALAQAYDQIGDDCPDLdDVAYLKKAFEATQDLIAKRLISAGHDISDGGLVVTLLEMAFAGNC 906
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 881 GLQLSLPAH-PNPLELMVSETPGALVEVPQVHLSEVLRAARDYRCVAHPLGTVGPEGQgnnVTVLQNETVVFQETLTSLQ 959
Cdd:PLN03206 907 GINVDLPSSgHSAFETLFAEELGLVLEVSRKNLDAVMEKLAAAGVTAEVIGQVTASPL---IEVKVDGATCLSEKTASLR 983
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 960 VSW--TSFSdemwnlvtpplhpLEDMHR-KDLGRLEHH-LGSLRAmclgSQLRLFSCP----------TSPRRVAALVLP 1025
Cdd:PLN03206 984 DMWeeTSFQ-------------LEKLQRlESCVAQEKEgLKSRKA----PTWKLSFTPaftdkkimnaTSKPKVAIIREE 1046
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 1026 GSSAPYALMAALQNTGFEVATVTVEELKRGQ-SLSGFSGLITClrTGcqASYA----SARGWVLAL-CNDPTcASTLTEF 1099
Cdd:PLN03206 1047 GSNGDREMAAAFYAAGFEPWDVTMSDLLNGRiSLDDFRGIVFV--GG--FSYAdvldSAKGWAGSIrFNEPL-LQQFQEF 1121
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 1100 LNRPDTFS--ICCGevgFQLLVALGVV-GRSESSPYTYGPTPPQRWAVNletNVSKLYDSHWLNIQIpQNTKSVFLRVLR 1176
Cdd:PLN03206 1122 YNRPDTFSlgVCNG---CQLMALLGWVpGPQVGGGLGAGGDPSQPRFVH---NESGRFECRFTSVTI-EDSPAIMLKGME 1194
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 1177 GTVLPSW-AQGEylGVRYEQDA--LEYILrQRGEITLTYHGNAADetlPARHYPRNPTGNST-VAGLTSSDGRHAALIID 1252
Cdd:PLN03206 1195 GSTLGVWaAHGE--GRAYFPDEsvLDEVL-KSNLAPVRYCDDDGE---PTEQYPFNPNGSPLgIAALCSPDGRHLAMMPH 1268
|
730 740 750
....*....|....*....|....*....|....*..
gi 2749266474 1253 PSLMFHPWQWQHVPPD--LTPLSMSPWAMAFQSIYLW 1287
Cdd:PLN03206 1269 PERCFLMWQFPWYPKEwgVDPAGPSPWLKMFQNAREW 1305
|
|
| PRK05297 |
PRK05297 |
phosphoribosylformylglycinamidine synthase; Provisional |
570-1287 |
4.84e-49 |
|
phosphoribosylformylglycinamidine synthase; Provisional
Pssm-ID: 235394 [Multi-domain] Cd Length: 1290 Bit Score: 191.17 E-value: 4.84e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 570 IHQLLRHATVGSKEFFTRHMDRCSNGLIAQQAGVGPLDIPVSDYhlvlhssmlaervaprvpdtveAITPSmanllhkDF 649
Cdd:PRK05297 632 VERVLRLPTVASKSFLITIGDRSVTGLVARDQMVGPWQVPVADC----------------------AVTAA-------SY 682
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 650 ETWvkalpqellpvpawRGQAMAMGEQAYKMATNVSTGATYAITEALTNLMFSPVSKLQDVVLTG---AVAWSP-EDhqA 725
Cdd:PRK05297 683 DGY--------------AGEAMAMGERTPVALLDAAASARMAVGEALTNIAAAPIGDLKRIKLSAnwmAAAGHPgED--A 746
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 726 GLLQeclfACK----EFCRELGVALsissaassPT----LSERhvriTQQQETVE----VLPFnSVVFTSWAEVKGSRYR 793
Cdd:PRK05297 747 RLYD----AVKavgmELCPALGITI--------PVgkdsLSMK----TKWQEGGEdkevTSPL-SLIISAFAPVEDVRKT 809
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 794 VTPD-VKVEGNALVY--LAVNQSCLiAGSTFE--HNFLASRhpIPPL-NPSTVASLFMLVKYLMSKRLIVSGHDIGDGGL 867
Cdd:PRK05297 810 LTPQlRTDKDTALLLidLGRGKNRL-GGSALAqvYNQLGDK--APDVdDAEDLKGFFNAIQALVAEGLLLAYHDRSDGGL 886
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 868 LPSAIEMALAGCRGLQLSLPA-HPNPLELMVSETPGALVEVPQVHLSEV---LRAARDYRCVaHPLGTVGPEGQgnnVTV 943
Cdd:PRK05297 887 LTTLAEMAFAGHCGLDIDLDAlGDDALAALFNEELGAVIQVRAADRDAVeaiLAEHGLSDCV-HVIGKPNAGDR---IVI 962
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 944 LQNETVVFQETLTSLQVSWTSFSdemwnlvtpplhpledmhrkdlgrleHHLGSLRAM--CLGSQLRLFSCPTSPRRVAA 1021
Cdd:PRK05297 963 TRNGKTVFSESRTELRRWWSETS--------------------------YQMQRLRDNpeCADQEFDAILDQADPGLNVK 1016
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 1022 L---VLPGSSAPYAL--------------------MA-ALQNTGFEVATVTVEELKRGQ-SLSGFSGLITClrTGcqASY 1076
Cdd:PRK05297 1017 LtfdPNEDIAAPFIAtgarpkvailreqgvnshveMAaAFDRAGFDAIDVHMSDLLAGRvTLEDFKGLVAC--GG--FSY 1092
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 1077 A----SARGWVLALCNDPTCASTLTEFLNRPDTFS--IC--CgevgfQLLVALGVV--GrSESSPytygptppqrwavNL 1146
Cdd:PRK05297 1093 GdvlgAGEGWAKSILFNPRLRDQFEAFFARPDTFAlgVCngC-----QMMSNLKEIipG-AEHWP-------------RF 1153
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 1147 ETNVSKLYDSHWLNIQIPQNtKSVFLRVLRGTVLPSW-AQGEylG-VRYEQDALEYILrQRGEITLTY---HGNAADetl 1221
Cdd:PRK05297 1154 VRNRSEQFEARFSLVEVQES-PSIFLQGMAGSRLPIAvAHGE--GrAEFPDAHLAALE-AKGLVALRYvdnHGQVTE--- 1226
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2749266474 1222 parHYPRNPTGNST-VAGLTSSDGRHAALIIDPSLMFHPWQWQHVPPDLTPLsmSPWAMAFQSIYLW 1287
Cdd:PRK05297 1227 ---TYPANPNGSPNgITGLTTADGRVTIMMPHPERVFRTVQNSWHPEEWGED--SPWMRMFRNARKW 1288
|
|
| PurL1 |
COG0046 |
Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and ... |
493-964 |
6.43e-35 |
|
Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain is part of the Pathway/BioSystem: Purine biosynthesis
Pssm-ID: 439816 [Multi-domain] Cd Length: 747 Bit Score: 144.04 E-value: 6.43e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 493 LQRAARLCA---CQITVLGRTSEQPGIRI-----------VDDLTGETtrvfsvdqPSSTPPSPWLALSDGVRVsghPED 558
Cdd:COG0046 334 LEEFEAIFErwrLPAAVIGEVTDDGRLVVtdhgetvadlpLDFLAGGA--------PKYHRPAKRPAYLEPLDL---PEP 402
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 559 VDWGlfatgSTIHQLLRHATVGSKEFFTRHMDRCSNGLIAqqagVGPldiPVSDyhlvlhSSMLaervapRVPDTveait 638
Cdd:COG0046 403 IDLE-----EALLRLLSSPNVASKEWLYRQYDREVGGNTV----RDP---GVAD------AAVV------RVDGT----- 453
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 639 psmanllhkdfetwvkalpqellpvpaWRGQAMAMGEQAYKMATNVSTGATYAITEALTNLMFSPVSKLqDVVLT---Ga 715
Cdd:COG0046 454 ---------------------------YKGLAMSTGENPRYALLDPYAGARMAVAEAARNLAAVGAEPL-AITDClnwG- 504
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 716 vawSPED-HQAGLLQECLFACKEFCRELGValsissaassPtlserhvrIT---------QQQETVEVLPfnSVVFTSWA 785
Cdd:COG0046 505 ---NPEKpEEMAQLVEAVKGLADACRALGI----------P--------VPsgnvslyneTKDGKVAIPP--TPVIGAVG 561
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 786 EVKGSRYRVTPDVKVEGNALVYLAVNQSCLiAGSTF--EHNFLASRhpIPPLNPSTVASLFMLVKYLMSKRLIVSGHDIG 863
Cdd:COG0046 562 LVDDVRKTVTPDLKKEGDLLYLIGETKNEL-GGSEYaqVLGQLGGE--PPDVDLEAEKALFEAVQELIREGLILAAHDVS 638
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 864 DGGLLPSAIEMALAGCRGLQLSLPAHPN--PLELMVSETPG-ALVEVPQVHLSEVLRAARDYRCVAHPLGTVGPEGQgnn 940
Cdd:COG0046 639 DGGLAVALAEMAFAGGLGADIDLDALGDlrPDAALFSESQGrAVVQVAPEDAEAVEALLAEAGLPAHVIGTVTGDDR--- 715
|
490 500
....*....|....*....|....
gi 2749266474 941 VTVLQNETVVFQETLTSLQVSWTS 964
Cdd:COG0046 716 LVIRRGGETLLSLSLAELRDAWEE 739
|
|
| PurL_repeat2 |
cd02204 |
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. ... |
661-932 |
2.12e-26 |
|
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100035 [Multi-domain] Cd Length: 264 Bit Score: 109.93 E-value: 2.12e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 661 LPVPAWRGQAMAMGEQAYKMATNVSTGATYAITEALTNLMFSPVSKLqDVVLTGAVAWsPEDHQA--GLLQECLFACKEF 738
Cdd:cd02204 7 IPGETDKGLAMSTGENPRYSLLDPYAGAALAVAEAVRNLVAVGADPL-AITDCLNFGN-PEKPEGemGQLVEAVLGLGDA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 739 CRELGValsissaassP------TLSerhvritQQQETVEVLPfnSVVFTSWAEVKGSRYRVTPDVKVEGNALVYLAVNQ 812
Cdd:cd02204 85 CRALGT----------PviggkdSLY-------NETEGVAIPP--TLVIGAVGVVDDVRKIVTLDFKKEGDLLYLIGETK 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 813 SCLIAGSTFEHNFLASRHPIPPLNPSTVASLFMLVKYLMSKRLIVSGHDIGDGGLLPSAIEMALAGCRGLQLSLPAHPNP 892
Cdd:cd02204 146 DELGGSEYALAYHGLGGGAPPLVDLEREKALFDAVQELIKEGLVLSAHDVSDGGLAVALAEMAFAGGLGAEVDLSKDDAE 225
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 2749266474 893 LELMVSETPGA-LVEVPQVHLSEVLRAARDYRCvaHPLGTV 932
Cdd:cd02204 226 DELLFSESLGRvLVEVKPENEEVFEAEEAGVPA--TVIGTV 264
|
|
| GATase1_FGAR_AT |
cd01740 |
Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ... |
1019-1285 |
1.05e-15 |
|
Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase (FGAR-AT). FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, Pi, and glutamate in the fourth step of the purine biosynthetic pathway. FGAR-AT is a glutamine amidotransferase. Glutamine amidotransferase activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate. FGAR-AT belongs to the triad family of amidotransferases having a conserved Cys-His-Glu catalytic triad in the glutaminase active site
Pssm-ID: 153211 [Multi-domain] Cd Length: 238 Bit Score: 78.04 E-value: 1.05e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 1019 VAALVLPGSS----APYALMAAlqntGFEVATVTVEELKRG-QSLSGFSGLITC--------LRtgcqasyaSARGWVLA 1085
Cdd:cd01740 1 VAVLRFPGSNcdrdMAYAFELA----GFEAEDVWHNDLLAGrKDLDDYDGVVLPggfsygdyLR--------AGAIAAAS 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 1086 lcndPTCASTLTEFlNRPDTFS--ICCGevgFQLLVALGVVgrsessPYTygptppqrwavnLETNVSKLYDSHWLNIQI 1163
Cdd:cd01740 69 ----PLLMEEVKEF-AERGGLVlgICNG---FQILVELGLL------PGA------------LIRNKGLKFICRWQNRFV 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 1164 ---PQNTKSVFLR-VLRGTVLPSW-AQGEylGvRY--EQDALEYILRQRGEITLTYHGNAADETlparhYPRNPTGnST- 1235
Cdd:cd01740 123 tlrVENNDSPFTKgYMEGEVLRIPvAHGE--G-RFyaDDETLAELEENGQIAQYVDDDGNVTER-----YPANPNG-SLd 193
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 2749266474 1236 -VAGLTSSDGRHAALIIDPSLMFHPWQWQHVPPDltplsmSPWAMAFQSIY 1285
Cdd:cd01740 194 gIAGICNEDGRVLGMMPHPERAVEPWQWERLLGG------SDGLKLFRNAV 238
|
|
| AIRS_C |
pfam02769 |
AIR synthase related protein, C-terminal domain; This family includes Hydrogen expression ... |
801-936 |
6.79e-13 |
|
AIR synthase related protein, C-terminal domain; This family includes Hydrogen expression/formation protein HypE, AIR synthases EC:6.3.3.1, FGAM synthase EC:6.3.5.3 and selenide, water dikinase EC:2.7.9.3. The function of the C-terminal domain of AIR synthase is unclear, but the cleft formed between N and C domains is postulated as a sulphate binding site.
Pssm-ID: 460684 [Multi-domain] Cd Length: 152 Bit Score: 67.76 E-value: 6.79e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 801 EGNALVYLavnqscliaGSTFEH--NFLASRHPI--PPLNPSTVASLFMLVKYLMSKR-------LIVSGHDIGDGGLLP 869
Cdd:pfam02769 2 PGDVLILL---------GSSGLHgaGLSLSRKGLedSGLAAVQLGDPLLEPTLIYVKLllaalggLVKAMHDITGGGLAG 72
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2749266474 870 SAIEMALAGCRGLQLSLPAHP------NPLELMVSETPG-ALVEVPQVHLSEVLRAARDYRCVAHPLGTVGPEG 936
Cdd:pfam02769 73 ALAEMAPASGVGAEIDLDKVPifeelmLPLEMLLSENQGrGLVVVAPEEAEAVLAILEKEGLEAAVIGEVTAGG 146
|
|
| PRK01213 |
PRK01213 |
phosphoribosylformylglycinamidine synthase subunit PurL; |
787-953 |
1.22e-12 |
|
phosphoribosylformylglycinamidine synthase subunit PurL;
Pssm-ID: 234921 [Multi-domain] Cd Length: 724 Bit Score: 72.44 E-value: 1.22e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 787 VKGSRYRVTPDVKVEGNALVYLAVNQSCLiAGSTFE---HNFLAsrHPIPPLNPSTVASLFMLVKYLMSKRLIVSGHDIG 863
Cdd:PRK01213 546 IDDVSKRTTSGFKKEGDLIYLLGETKDEL-GGSEYLkviHGHVG--GRPPKVDLEAEKRLQELVREAIREGLVTSAHDVS 622
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 864 DGGLLPSAIEMALAGCRGLQLSLPAHPNPLELMVSETPG-ALVEVPQVHLSEVLRAARDYRCVAHPLGTVGpegqGNNVT 942
Cdd:PRK01213 623 EGGLAVALAEMAIAGGLGAEVDLSDGLRPDALLFSESQGrYVVSVPPENEEAFEALAEAAGVPATRIGVVG----GDALK 698
|
170
....*....|.
gi 2749266474 943 VLQNETVVFQE 953
Cdd:PRK01213 699 VKGNDTESLEE 709
|
|
| PurL |
cd02193 |
Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent ... |
668-932 |
9.03e-08 |
|
Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100029 [Multi-domain] Cd Length: 272 Bit Score: 55.00 E-value: 9.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 668 GQAMAMGEQAYKMATNVSTGATYAITEALTNLMFSPVSKLQDVVLTGAVAWSPEDHQAGLLQECLFACKEFCRELGVALs 747
Cdd:cd02193 2 GEAMKIEEHNHPAAIDPAAGAATGVGGAIRDIAATGIDAKPIALSANWMASAGHPGEDAILYDAVKGVAELCNQLGLPI- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 748 issaassPTLSERHVRITQQQETVEVLPFNS---VVFTSWAEVKGSRYrVTPDVKVEGNALVYLAVNQSCL-IAGSTFEH 823
Cdd:cd02193 81 -------PVGKDRMSMKTRWQEGNEQREMTHppsLVISAFGRVRDDRH-TLPQLSTEGNALLLIGGGKGHNgLGGTALAS 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 824 NFLASRH----PIPPLNPSTVASLFMLVKYLMSKRLIVSGHDIGDGGLLPSAIEMALAGCRGLQLSLPA----HPN--PL 893
Cdd:cd02193 153 VALSYRQlgdkSAQVRDPAQEKGFYEAMQALVAAGKLLAWHDRGAGGLLVALAELVFAGHCGVQVDLAAlgddEPDmePL 232
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 2749266474 894 ELMVSETP--GALVEVPQvHLSEVLRAARDYRCVAHPLGTV 932
Cdd:cd02193 233 EIALFESQerGVIQVRAE-DRDAVEEAQYGLADCVHVLGQA 272
|
|
| PurL_repeat1 |
cd02203 |
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. ... |
850-951 |
1.51e-07 |
|
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100034 [Multi-domain] Cd Length: 313 Bit Score: 54.79 E-value: 1.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 850 LMSKRLIVSGHDIGDGGLLPSAIEMALAGCRGLQLSLPAHP------NPLELMVSET-PGALVEVPQVHLSEVLRAARDY 922
Cdd:cd02203 206 ARETGLIVGIQDLGAGGLSSAVSEMAAKGGLGAEIDLDKVPlrepgmSPWEIWISESqERMLLVVPPEDLEEFLAICKKE 285
|
90 100
....*....|....*....|....*....
gi 2749266474 923 RCVAHPLGTVGPEGqgnNVTVLQNETVVF 951
Cdd:cd02203 286 DLEAAVIGEVTDDG---RLRLYYKGEVVA 311
|
|
| PurL1 |
COG0046 |
Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and ... |
850-950 |
5.26e-06 |
|
Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain is part of the Pathway/BioSystem: Purine biosynthesis
Pssm-ID: 439816 [Multi-domain] Cd Length: 747 Bit Score: 50.82 E-value: 5.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 850 LMSKRLIVSGHDIGDGGLLPSAIEMALAGCRGLQLSLPAHPN------PLELMVSEtpgA----LVEVPQVHLSEVLRAA 919
Cdd:COG0046 265 LGDTGLIVGIQDMGAGGLSSASSEMAAKGGLGAEIDLDKVPLrepgmsPYEIWLSE---SqermLLVVKPEKLEEFEAIF 341
|
90 100 110
....*....|....*....|....*....|.
gi 2749266474 920 RDYRCVAHPLGTVGPEGQgnnVTVLQNETVV 950
Cdd:COG0046 342 ERWRLPAAVIGEVTDDGR---LVVTDHGETV 369
|
|
| FGAM_synth_II |
TIGR01736 |
phosphoribosylformylglycinamidine synthase II; Phosphoribosylformylglycinamidine synthase is a ... |
687-969 |
5.50e-06 |
|
phosphoribosylformylglycinamidine synthase II; Phosphoribosylformylglycinamidine synthase is a single, long polypeptide in most Proteobacteria and eukarotes. Three proteins are required in Bacillus subtilis and many other species. This is the longest of the three and is designated PurL, phosphoribosylformylglycinamidine synthase II, or FGAM synthase II. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 273781 [Multi-domain] Cd Length: 715 Bit Score: 50.76 E-value: 5.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 687 GATYAITEALTNLmfspvsklqdvVLTGAVAW---------SPEDHQA-GLLQECLFACKEFCRELGValsissaassPT 756
Cdd:TIGR01736 451 GAAGAVAEAYRNL-----------AAVGAEPLaavdclnfgNPERPEVyWQFVEAVKGLGDACRALGT----------PV 509
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 757 LSErHVRITQQQETVEVLPfnSVVFTSWAEVKGSRYRVTPDVKVEGNAlVYLaVNQSCL-IAGSTFEHN-FLASRHPIPP 834
Cdd:TIGR01736 510 VGG-NVSLYNETNGVPIAP--TPTIGMVGLVEDVEKLLTSNFKKEGDA-IYL-IGETKDeLGGSEYLRViHGIVSGQVPA 584
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 835 LNPSTVASLFMLVKYLMSKRLIVSGHDIGDGGLLPSAIEMALAGCRGLQLSLPAHP--NPLELMVSETPG-ALVEVP--- 908
Cdd:TIGR01736 585 VDLEEEKELADAVREAIRAGLVSAAHDVSRGGLAVALAEMAAASGIGAEVDIDEIAsaRPDELLFSESNGrAIVAVPeek 664
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2749266474 909 --QVHLSEVLRAARdyrcvahpLGTVGpegqGNNVTVLQNETVVfQETLTSLQVSWTSFSDEM 969
Cdd:TIGR01736 665 aeEAVKSKGVPAKV--------IGKTG----GDRLTIKTGDDTI-SVSVKELRDAWEEALPEY 714
|
|
| PRK01175 |
PRK01175 |
phosphoribosylformylglycinamidine synthase I; Provisional |
1016-1261 |
4.14e-04 |
|
phosphoribosylformylglycinamidine synthase I; Provisional
Pssm-ID: 234913 [Multi-domain] Cd Length: 261 Bit Score: 43.60 E-value: 4.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 1016 PRRVAALVLPGSSAPYALMAALQNTGFEVATVTVEELKRGQ-SLSGFSGLItcLRTGCQA-SYASArGWVLALCNDPTCA 1093
Cdd:PRK01175 3 SIRVAVLRMEGTNCEDETVKAFRRLGVEPEYVHINDLAAERkSVSDYDCLV--IPGGFSAgDYIRA-GAIFAARLKAVLR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 1094 STLTEFLN--RPdTFSICCgevGFQLLVALGVV-GRSESSpytygptppQRWAVNLETNVSKLYDSHWLNIQIpQNTKSV 1170
Cdd:PRK01175 80 KDIEEFIDegYP-IIGICN---GFQVLVELGLLpGFDEIA---------EKPEMALTVNESNRFECRPTYLKK-ENRKCI 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 1171 FLRVLRGTV--LPSwAQGEYLGVRYEQDALEYILrQRGEITLTY---HGNAAdetlparHYPRNPTGN-STVAGLTSSDG 1244
Cdd:PRK01175 146 FTKLLKKDVfqVPV-AHAEGRVVFSEEEILERLI-ENDQIVFRYvdeNGNYA-------GYPWNPNGSiYNIAGITNEKG 216
|
250
....*....|....*..
gi 2749266474 1245 RHAALIIDPSLMFHPWQ 1261
Cdd:PRK01175 217 NVIGLMPHPERAFYGYQ 233
|
|
| FGAM_synth_II |
TIGR01736 |
phosphoribosylformylglycinamidine synthase II; Phosphoribosylformylglycinamidine synthase is a ... |
850-936 |
1.36e-03 |
|
phosphoribosylformylglycinamidine synthase II; Phosphoribosylformylglycinamidine synthase is a single, long polypeptide in most Proteobacteria and eukarotes. Three proteins are required in Bacillus subtilis and many other species. This is the longest of the three and is designated PurL, phosphoribosylformylglycinamidine synthase II, or FGAM synthase II. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 273781 [Multi-domain] Cd Length: 715 Bit Score: 43.06 E-value: 1.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2749266474 850 LMSKRLIVSGHDIGDGGLLPSAIEMALAGCRGLQLSLPAHP------NPLELMVSETPG-ALVEVPQVHLSEVLRAARDY 922
Cdd:TIGR01736 241 AVDTGLVKGIKDLGAAGLTSASSEMAAKGGLGAEIYLDKVPlrepgmTPYEIMLSESQErMLLVVAPEDVEEVLEIFEKY 320
|
90
....*....|....
gi 2749266474 923 RCVAHPLGTVGPEG 936
Cdd:TIGR01736 321 ELPASVIGEVTDEG 334
|
|
| |
