|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07726 |
PRK07726 |
DNA topoisomerase 3; |
1-670 |
0e+00 |
|
DNA topoisomerase 3;
Pssm-ID: 236078 [Multi-domain] Cd Length: 658 Bit Score: 651.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 1 MRLFIAEKPSLAKAIFEGLggnPNTEKKNGYFEHGSDVVTWCYGHMLELYDPEDYDEKYSNWRFSDLPIksvYPP--QYK 78
Cdd:PRK07726 1 MRLFIAEKPSVGRDIADVL---KPHKKGDGYIEGNGYIVTWAIGHLLELAEPEAYDERYKRWRLEDLPI---IPEkwKLV 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 79 IKPESEAQTRIILSLIDKADNIVHAGDPDEEGCLLVDEILGYAKNTKSVYRLLVRDLNLAPVQKALTDLQPNDKFRGMTL 158
Cdd:PRK07726 75 VKKKTAKQFNVVKKLLKQATEIVIATDADREGELIAREILDYCGVRKPIKRLWISSLTDKAIKRAFANLKPGKETIPLYY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 159 SALARSLCDQGFGYNMTRGCTLKGREKGYDGVLNVGRVQSAVLGLVNMRtlanQNHTESF----YYDVFASLLMNGHLiK 234
Cdd:PRK07726 155 SALARSRADWLVGINMTRAYTLLGRKAGYNGVLSVGRVQTPTLALVVRR----DEEIENFvpkpYWEVEAHLTPGERF-T 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 235 AKYQTTDDDQiDEKKRLISEAQAAHIAGRVTGKDAVVTIATTKPENTKPPLPLNLSTLQQLCAKRFGYSAKDTLDVMQGL 314
Cdd:PRK07726 230 AKWQPSEPYQ-DEEGRLLDRPLAEQVVARIQGQPAKVTEVETKRKKEYAPLLYDLSELQIDANKRFGLSAKETLDIAQSL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 315 YETHKLLTYPRSDNRYLSDEHYYQAGDIATAIAATVPELASAIADMDKSQKHKAFNASKIEAHHAIIPTTKSGAGIQLNE 394
Cdd:PRK07726 309 YETHKLITYPRTDSRYLPEDMVATLPEVLNAISKVDPYLLLAPPVLDPSIRSRAWNDKKVTAHHAIIPTEQPPNLSKLSE 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 395 KERNVYNLVSVYFIGLFYPDAIRNKTKIHFDIKGDTFTATQSVLVQKGW-EALGKDNDDEDETEDagtdgfdLSSLKFND 473
Cdd:PRK07726 389 DERKVYDLIARRYLAQFLPPAEYDKTTIELEIAGGTFIAKGKQVVEAGWkALLGKKEEDEEKEQP-------LPVLAKGD 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 474 SGLCESADVDKKKTNPPRYFTASTLLAAMTSAAKFIDDPALRKALeakdegsEDRGSIGTEATRAGILEKLaANTGLisI 553
Cdd:PRK07726 462 ELKVEKGEVKEGQTQPPKRFTEGTLLSAMENIARFVQDKELKKTL-------KETDGLGTEATRAGIIEKL-FKRGY--L 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 554 EKEKGYselVWKTTKqGQEFCAALPPEITKPDISALWAEKQSQIKAGELTVEEFIKENDEYVQGLIDELERNGVSISSN- 632
Cdd:PRK07726 532 EKKGKY---IHATDK-GKQLIDALPEELTSPDMTAKWEQALDQISEGQLSYQDFMQPLKQWLKQLVEQAKQSSEKYKFDn 607
|
650 660 670 680
....*....|....*....|....*....|....*....|
gi 2785401644 633 --ATPCPVCnNGFLRKRKGQNGFFWGCSCYPECKTTFPDK 670
Cdd:PRK07726 608 ltGPKCPDC-GKPMLKVKGKNGKMLVCQDRECGKRKNVSK 646
|
|
| topB |
TIGR01056 |
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase ... |
1-664 |
0e+00 |
|
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273419 [Multi-domain] Cd Length: 660 Bit Score: 532.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 1 MRLFIAEKPSLAKAIFEGLggnPNTEKKNGYFEHG-SDVVTWCYGHMLELYDPEDYDEKYSNWRFSDLPIKSvYPPQYKI 79
Cdd:TIGR01056 1 MTLVLCEKPSQARDLATVL---AKKKKGNGYLEIGvGGFVTWAVGHLVELAEPEEYDEKYKNWRTYDLPLEP-EDWQLVV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 80 KPESEAQTRIILSLI--DKADNIVHAGDPDEEGCLLVDEILGYAKNTKS--VYRLLVRDLNLAPVQKALTDLQPNDKFRG 155
Cdd:TIGR01056 77 SDKTKKQFNVIKRILkeNKVDEVVIATDPDREGELIAREILDYLKVTDKvtIKRLWISSLVDSSIRKAFKNLRPKSETEG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 156 MTLSALARSLCDQGFGYNMTRGCTLKGREKGYDGVLNVGRVQSAVLGLVNMRTLANQNHTESFYYDVFASLLMNGHLIKA 235
Cdd:TIGR01056 157 LYKSGVARARADWLVGINLTRAFTKLGREAGNDGVLSVGRVQTPTLAMVVKRENEIKNFVGKPFYEVSATINKDEQEFTT 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 236 KYQttddDQIDEKKRLISEAQAAHIAGRVTGKDAVVTIATTKPENTKPPLPLNLSTLQQLCAKRFGYSAKDTLDVMQGLY 315
Cdd:TIGR01056 237 EWQ----PYKDEEERELHEFLAENVVTDLTQKPALVTDIEKERKKTSAPLFYDLSALQEDANKRFGISAKRTLDIAQKLY 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 316 ETHKLLTYPRSDNRYLSDEHYYQAGDIATAIAATVPELASaIADMDKSQKHKAFNASKIEAHHAIIPTTKSGAGIQLNEK 395
Cdd:TIGR01056 313 ETHKLITYPRTDSRYLPEDEKEMLLEVLDALKVITPALLP-IKKRDELTNNRLWNDKKIEDHHAIIPTGNDFNLSDLSEE 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 396 ERNVYNLVSVYFIGLFYPDAIRNKTKIHFDIKGDTFTATQSVLVQKGWEAL-GKDNDDEDetedagTDGFDLSSLKFNDS 474
Cdd:TIGR01056 392 ERNVYKLIAQNYLMQFMPKEEYETTTIEIAIGKLMFEAKGKILQDNGWKALlGKQEEDEE------TEDTTLPAFQKGDE 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 475 GLCESADVDKKKTNPPRYFTASTLLAAMTSAAKFIDDPALRKALEAKDegsedrgSIGTEATRAGILEKLaANTGLISIE 554
Cdd:TIGR01056 466 LDVETLELLEKQTKPPARYTEGTLLSAMTNPAAFVQDKGLKKTLKETK-------GLGTEATRADIIENL-FKRGFIQKK 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 555 KEKGYSelvwktTKQGQEFCAALPPEITKPDISALWAEKQSQIKAGELTVEEFIKENDEYVQGLIDELERNGVSISS-NA 633
Cdd:TIGR01056 538 KNKIYI------TKNGKLLCLLLPELLTKPDLTAQWEQYLNGISAGEKDDDDFINTINEMIKQTINEEKKNPETIQKvAK 611
|
650 660 670
....*....|....*....|....*....|.
gi 2785401644 634 TPCPvCNNGFLRKRKgQNGFFWGCSCYPECK 664
Cdd:TIGR01056 612 EPVS-CGGIAKCPAK-DNGRLIDCKKFPECT 640
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
1-620 |
9.84e-109 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 342.46 E-value: 9.84e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 1 MRLFIAEKPSLAKAIFEGLGgnpntekkNGYfehgsdVVTWCYGHMLELYDPE-DYDEKYsNWRfsdlpiksvypPQYKI 79
Cdd:COG0550 1 KKLVIVESPAKAKTIAKYLG--------KDY------VVTASVGHLRDLPKPElDVDVEN-DFE-----------PKYEV 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 80 KPESEAQTRIILSLIDKADNIVHAGDPDEEGCLLVDEILGYAKNTKSVYRLLVRDLNLAPVQKALTDLQPNDkfRGMTLS 159
Cdd:COG0550 55 IPGKKKQVKELKKLAKKADEVILATDPDREGEAIAWHLLELLGDKKPVKRVVFNEITKKAIKEAFKNPRDID--MNLVDA 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 160 ALARSLCDQGFGYNMTRGCTLKGREKgydgvLNVGRVQSAVLGLVNMRTLANQNHTESFYYDVFASLLMNGHLIKAKYQT 239
Cdd:COG0550 133 QQARRILDRLVGYNLSPLLWKKVKRG-----LSAGRVQSPALRLIVEREREIEAFVPEEYWTIEATFKTGGGEFTAKLVK 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 240 TDddqideKKRLISEAQAAHIAGRVTGKDAVVTIATTKPENTKPPLPLNLSTLQQLCAKRFGYSAKDTLDVMQGLYEThK 319
Cdd:COG0550 208 ID------GKKILDEEEAEAILAALKGKTFTVTSVEKKPKKRNPPPPFTTSTLQQEASRKLGFSAKKTMSIAQRLYEV-G 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 320 LLTYPRSDNRYLSDEhyyqagdiataIAATVPELASAIADMD-KSQKHKAFNASK--IEAHHAIIPTTKSGAGIQLNEKE 396
Cdd:COG0550 281 LITYMRTDSVRLSED-----------AVAAAREYIEALYGKEyLPEKPRVYKTSKnaQEAHEAIRPTGVTRTPESLSGDE 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 397 RNVYNLVSVYFIGLFYPDAIRNKTKIHFDIKGDTFTATQSVLVQKGWEALgkdnDDEDETEDAGTDGFDLSSLKFNDSGL 476
Cdd:COG0550 350 FKLYDLIWKRFLASQMPPAEYETTTVTIEVGGEEFRASGKVIKFPGFLKV----YGEGKDDEEEEEEKRLPPLKEGEKLK 425
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 477 CESADVDKKKTNPPRYFTASTLLAAMtsaakfiddpalrkaleakdegsEDRGsIGTEATRAGILEKLaANTGLISIEKe 556
Cdd:COG0550 426 LKKIEPEQHFTKPPPRYTEASLVKAM-----------------------EELG-IGRPSTYASIIETL-QDRGYVEREG- 479
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2785401644 557 kgySELVwkTTKQGQEFCAALP---PEITKPDISALWAEKQSQIKAGELTVEEFIKENDEYVQGLID 620
Cdd:COG0550 480 ---KRLV--PTELGFIVIDLLEehfPDLVDYEFTAKMEEKLDEIAEGKLDWKDVLEEFYKPFKELVE 541
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
151-609 |
1.22e-90 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 290.68 E-value: 1.22e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 151 DKFRGMTLSALARSLCDQGFGYNMTRGCTLKgreKGYDGVLNVGRVQSAVLGLVNMRTLANQNHTESFYYDVFASLLMNG 230
Cdd:pfam01131 1 EIDENLVDAQLARRELDWLIGFNLSRLLTLK---LKGNKLLSAGRVQTPTLALIVEREREIENFVPEPYWTIEATLKDGG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 231 HLIKAKYqttdddqiDEKKRLISEAQAAHIAGRVTGKDAVVTIATTKPENTKPPLPLNLSTLQQLCAKRFGYSAKDTLDV 310
Cdd:pfam01131 78 GVFANAK--------WKRGRIFDKEEAEAILEKLKKGTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSI 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 311 MQGLYETHKLLTYPRSDNRYLSDEhyYQAGDIATAIAATVPELASAIADMDKSQKHKA-FNASKIEAHHAIIPTTKSGAG 389
Cdd:pfam01131 150 AQKLYEKHGLITYPRTDSTYLSDD--ATLKAILEYLTKNYGKYLPYAPRLLKKTKGKLtVGNAKVTAHEAIRPTGDIPVL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 390 IQLNEKERNVYNLVSVYFIGLFYPDAIRNKTKIHFDIKGDTFTATQSVLVQKGWEALGKDNDDEdetedagtDGFDLSSL 469
Cdd:pfam01131 228 PELSDDERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVYPYEKKE--------DEEELPEL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 470 KFNDSGLCESADVDKKKTNPPRYFTASTLLAAMtsaakfiddpalrkaleakdegsEDRGsIGTEATRAGILEKLaantg 549
Cdd:pfam01131 300 KEGEELKVTQVEVEEKKTKPPPRYTEASLIKAM-----------------------EKAG-IGTPATRATIIETL----- 350
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2785401644 550 lisieKEKGYSELVWKT---TKQGQEFCAALP--PEITKPDISALWAEKQSQIKAGELTVEEFIK 609
Cdd:pfam01131 351 -----LERGYVERKKKSlvpTELGKALVEALEkfPDLVDPELTAELEEKLDEIAEGKLDWKDVLA 410
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
277-559 |
6.80e-53 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 183.99 E-value: 6.80e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 277 KPENTKPPLPLNLSTLQQLCAKRFGYSAKDTLDVMQGLYEtHKLLTYPRSDNRYLSDEHYYQAgdiATAIAATVPELASA 356
Cdd:smart00437 3 KEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYE-KGLITYPRTDSTRLSEEAVLEA---RNYIQKLYGKEYLD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 357 IADMDKSQKHKAFNASKIEAHHAIIPT---TKSGAGIQLNEKERNVYNLVSVYFIGLFYPDAIRNKTKIHFDIKGDTFTA 433
Cdd:smart00437 79 LAVVLLKPRKPRKGKKAQGAHEAIRPTkpiFTPELEKELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFKA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 434 TQSVLVQKGWEALGKDNDDedetedagTDGFDLSSLKFNDSGLCESADVDKKKTNPPRYFTASTLLAAMtsaakfiddpa 513
Cdd:smart00437 159 KGKTLLFDGWLKVYPEEKK--------EEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLM----------- 219
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 2785401644 514 lrkaleakdegsEDRGsIGTEATRAGILEKLaantglisieKEKGY 559
Cdd:smart00437 220 ------------EKRG-IGRPSTYASIIETL----------LDRGY 242
|
|
| TOPRIM_TopoIA_TopoIII |
cd03362 |
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type ... |
1-147 |
1.76e-38 |
|
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173782 [Multi-domain] Cd Length: 151 Bit Score: 140.06 E-value: 1.76e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 1 MRLFIAEKPSLAKAIFEGLGGNPNTEKK--NGYFEHGSD--VVTWCYGHMLELYDPEDYDEKYSNWRFSDLPIKSvyPPQ 76
Cdd:cd03362 1 MVLIIAEKPSVAKAIAKILGGGSKKKGKgrYYEFYGEGGgyVVTWASGHLLELDFPEEYDPWDKVWPLEDPLFPA--PFK 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2785401644 77 YKIKPESEAQTRIILSLIDKADNIVHAGDPDEEGCLLVDEILGYAKN--TKSVYRLLVRDLNLAPVQKALTDL 147
Cdd:cd03362 79 LKVDKGKKKQFKVLKKLAKRADEIVIATDADREGELIGREILEYAKCvkRKPVKRAWFSSLTPKAIRRAFKNL 151
|
|
| Toprim_Crpt |
pfam13342 |
C-terminal repeat of topoisomerase; |
711-772 |
9.91e-20 |
|
C-terminal repeat of topoisomerase;
Pssm-ID: 463851 [Multi-domain] Cd Length: 60 Bit Score: 83.30 E-value: 9.91e-20
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2785401644 711 GCEFKIWSEVSGKKLTQNQVETLIKKGKTGEIKGFTSnKTGKKFDAAIVLQDKatGKLGFQF 772
Cdd:pfam13342 1 GCGFSIGKTIAGKKLSEEQVKELLTKGKTGLIKGFKS-KKGKKFDAYLVLDDD--EKVEFDF 59
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07726 |
PRK07726 |
DNA topoisomerase 3; |
1-670 |
0e+00 |
|
DNA topoisomerase 3;
Pssm-ID: 236078 [Multi-domain] Cd Length: 658 Bit Score: 651.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 1 MRLFIAEKPSLAKAIFEGLggnPNTEKKNGYFEHGSDVVTWCYGHMLELYDPEDYDEKYSNWRFSDLPIksvYPP--QYK 78
Cdd:PRK07726 1 MRLFIAEKPSVGRDIADVL---KPHKKGDGYIEGNGYIVTWAIGHLLELAEPEAYDERYKRWRLEDLPI---IPEkwKLV 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 79 IKPESEAQTRIILSLIDKADNIVHAGDPDEEGCLLVDEILGYAKNTKSVYRLLVRDLNLAPVQKALTDLQPNDKFRGMTL 158
Cdd:PRK07726 75 VKKKTAKQFNVVKKLLKQATEIVIATDADREGELIAREILDYCGVRKPIKRLWISSLTDKAIKRAFANLKPGKETIPLYY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 159 SALARSLCDQGFGYNMTRGCTLKGREKGYDGVLNVGRVQSAVLGLVNMRtlanQNHTESF----YYDVFASLLMNGHLiK 234
Cdd:PRK07726 155 SALARSRADWLVGINMTRAYTLLGRKAGYNGVLSVGRVQTPTLALVVRR----DEEIENFvpkpYWEVEAHLTPGERF-T 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 235 AKYQTTDDDQiDEKKRLISEAQAAHIAGRVTGKDAVVTIATTKPENTKPPLPLNLSTLQQLCAKRFGYSAKDTLDVMQGL 314
Cdd:PRK07726 230 AKWQPSEPYQ-DEEGRLLDRPLAEQVVARIQGQPAKVTEVETKRKKEYAPLLYDLSELQIDANKRFGLSAKETLDIAQSL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 315 YETHKLLTYPRSDNRYLSDEHYYQAGDIATAIAATVPELASAIADMDKSQKHKAFNASKIEAHHAIIPTTKSGAGIQLNE 394
Cdd:PRK07726 309 YETHKLITYPRTDSRYLPEDMVATLPEVLNAISKVDPYLLLAPPVLDPSIRSRAWNDKKVTAHHAIIPTEQPPNLSKLSE 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 395 KERNVYNLVSVYFIGLFYPDAIRNKTKIHFDIKGDTFTATQSVLVQKGW-EALGKDNDDEDETEDagtdgfdLSSLKFND 473
Cdd:PRK07726 389 DERKVYDLIARRYLAQFLPPAEYDKTTIELEIAGGTFIAKGKQVVEAGWkALLGKKEEDEEKEQP-------LPVLAKGD 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 474 SGLCESADVDKKKTNPPRYFTASTLLAAMTSAAKFIDDPALRKALeakdegsEDRGSIGTEATRAGILEKLaANTGLisI 553
Cdd:PRK07726 462 ELKVEKGEVKEGQTQPPKRFTEGTLLSAMENIARFVQDKELKKTL-------KETDGLGTEATRAGIIEKL-FKRGY--L 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 554 EKEKGYselVWKTTKqGQEFCAALPPEITKPDISALWAEKQSQIKAGELTVEEFIKENDEYVQGLIDELERNGVSISSN- 632
Cdd:PRK07726 532 EKKGKY---IHATDK-GKQLIDALPEELTSPDMTAKWEQALDQISEGQLSYQDFMQPLKQWLKQLVEQAKQSSEKYKFDn 607
|
650 660 670 680
....*....|....*....|....*....|....*....|
gi 2785401644 633 --ATPCPVCnNGFLRKRKGQNGFFWGCSCYPECKTTFPDK 670
Cdd:PRK07726 608 ltGPKCPDC-GKPMLKVKGKNGKMLVCQDRECGKRKNVSK 646
|
|
| topB |
TIGR01056 |
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase ... |
1-664 |
0e+00 |
|
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273419 [Multi-domain] Cd Length: 660 Bit Score: 532.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 1 MRLFIAEKPSLAKAIFEGLggnPNTEKKNGYFEHG-SDVVTWCYGHMLELYDPEDYDEKYSNWRFSDLPIKSvYPPQYKI 79
Cdd:TIGR01056 1 MTLVLCEKPSQARDLATVL---AKKKKGNGYLEIGvGGFVTWAVGHLVELAEPEEYDEKYKNWRTYDLPLEP-EDWQLVV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 80 KPESEAQTRIILSLI--DKADNIVHAGDPDEEGCLLVDEILGYAKNTKS--VYRLLVRDLNLAPVQKALTDLQPNDKFRG 155
Cdd:TIGR01056 77 SDKTKKQFNVIKRILkeNKVDEVVIATDPDREGELIAREILDYLKVTDKvtIKRLWISSLVDSSIRKAFKNLRPKSETEG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 156 MTLSALARSLCDQGFGYNMTRGCTLKGREKGYDGVLNVGRVQSAVLGLVNMRTLANQNHTESFYYDVFASLLMNGHLIKA 235
Cdd:TIGR01056 157 LYKSGVARARADWLVGINLTRAFTKLGREAGNDGVLSVGRVQTPTLAMVVKRENEIKNFVGKPFYEVSATINKDEQEFTT 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 236 KYQttddDQIDEKKRLISEAQAAHIAGRVTGKDAVVTIATTKPENTKPPLPLNLSTLQQLCAKRFGYSAKDTLDVMQGLY 315
Cdd:TIGR01056 237 EWQ----PYKDEEERELHEFLAENVVTDLTQKPALVTDIEKERKKTSAPLFYDLSALQEDANKRFGISAKRTLDIAQKLY 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 316 ETHKLLTYPRSDNRYLSDEHYYQAGDIATAIAATVPELASaIADMDKSQKHKAFNASKIEAHHAIIPTTKSGAGIQLNEK 395
Cdd:TIGR01056 313 ETHKLITYPRTDSRYLPEDEKEMLLEVLDALKVITPALLP-IKKRDELTNNRLWNDKKIEDHHAIIPTGNDFNLSDLSEE 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 396 ERNVYNLVSVYFIGLFYPDAIRNKTKIHFDIKGDTFTATQSVLVQKGWEAL-GKDNDDEDetedagTDGFDLSSLKFNDS 474
Cdd:TIGR01056 392 ERNVYKLIAQNYLMQFMPKEEYETTTIEIAIGKLMFEAKGKILQDNGWKALlGKQEEDEE------TEDTTLPAFQKGDE 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 475 GLCESADVDKKKTNPPRYFTASTLLAAMTSAAKFIDDPALRKALEAKDegsedrgSIGTEATRAGILEKLaANTGLISIE 554
Cdd:TIGR01056 466 LDVETLELLEKQTKPPARYTEGTLLSAMTNPAAFVQDKGLKKTLKETK-------GLGTEATRADIIENL-FKRGFIQKK 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 555 KEKGYSelvwktTKQGQEFCAALPPEITKPDISALWAEKQSQIKAGELTVEEFIKENDEYVQGLIDELERNGVSISS-NA 633
Cdd:TIGR01056 538 KNKIYI------TKNGKLLCLLLPELLTKPDLTAQWEQYLNGISAGEKDDDDFINTINEMIKQTINEEKKNPETIQKvAK 611
|
650 660 670
....*....|....*....|....*....|.
gi 2785401644 634 TPCPvCNNGFLRKRKgQNGFFWGCSCYPECK 664
Cdd:TIGR01056 612 EPVS-CGGIAKCPAK-DNGRLIDCKKFPECT 640
|
|
| PRK08173 |
PRK08173 |
DNA topoisomerase III; Validated |
3-775 |
7.85e-109 |
|
DNA topoisomerase III; Validated
Pssm-ID: 236172 [Multi-domain] Cd Length: 862 Bit Score: 352.05 E-value: 7.85e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 3 LFIAEKPSLAKAIFEGLGGnpnTEKKNGYFEHGSDVVTWCYGHMLELYDPEDYDEKYSNWRFSDLPiksVYPPQYKIKP- 81
Cdd:PRK08173 5 LIIAEKPSVANDIARALGG---FTKHDEYFESDEYVLSSAVGHLLEIAAPEEYEVKRGKWSFAHLP---VIPPHFDLNPi 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 82 -ESEAQTRIILSLIDKAD--NIVHAGDPDEEGCLLVDEILGYAKNTKSVYRLLVRDLNLAPVQKALTDLQPNDKFRGMTL 158
Cdd:PRK08173 79 aKTESRLKVLTKLIKRKDvtRLINACDAGREGELIFRLIAQHAKAKKPVKRLWLQSMTPQAIRDGFANLRSDEDMQPLAD 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 159 SALARSLCDQGFGYNMTRGCTLKGREKGYDGVLNVGRVQSAVLGLVNMRTLANQNHTESFYYDVFASL-----LMNGHLI 233
Cdd:PRK08173 159 AARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVRAEFvaaagFYEGRWF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 234 KAKYQTTDDDQIDEKKRLISEAQAAHIAGRVTGKDAVVTiATTKPENTKPPLPLNLSTLQQLCAKRFGYSAKDTLDVMQG 313
Cdd:PRK08173 239 DPKFKKDEFDPEKRASRLWSEAAAEAIVAACRGKPGTVT-EESKPSTQLSPLLFDLTSLQREANGRFGFSAKNTLGLAQA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 314 LYETHKLLTYPRSDNRYLSDEHYYQAGDIATAIAATVPELASA--IADMD--KSQKhKAFNASKIEAHHAIIPTTKSGAG 389
Cdd:PRK08173 318 LYEKHKVLTYPRTDSRALPEDYLGTVKQTLEMLKESNNYLPHAkqILDKGwvKPNK-RIFDNSKISDHFAIIPTLQAPKS 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 390 iqLNEKERNVYNLVSVYFIGLFYPDA-IRNKTKIHfDIKGDTFTATQSVLVQKGWEAL-GKdnddedeteDAGTDGFDLS 467
Cdd:PRK08173 397 --LSEPEQKLYDLVVKRFLAVFFPAAeFLVTTRIT-EVAGHHFKTEGKVLVNPGWLAVyGK---------EAQGADANLV 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 468 SLKFNDSGLCESADVDKKKTNPPRYFTASTLLAAMTSAAKFIDDPALRKALEAKdegsedrgSIGTEATRAGILEKLAAN 547
Cdd:PRK08173 465 PVQKGEKVKTDKIEAVALTTKPPARYNEATLLSAMEGAGKLVEDDELREAMAEK--------GLGTPATRAAIIEGLLGE 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 548 TGLISIEKekgysELVwKTTKQGQEFC--AALP-PEITKPDISALWAEKQSQIKAGELTVEEFIKENDEYVQGLID---E 621
Cdd:PRK08173 537 KYLVREGR-----ELI-PTAKAFQLMTllRGLGvEELTSPELTGEWEYKLSQIERGKLSRDAFMQEIAQMTQQIVKrakE 610
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 622 LERNGVS--ISSNATPCPVCNN--------------GF-------------------LRKRK-GQ-NGFF--WGCSCYPE 662
Cdd:PRK08173 611 YDSDTIPgdYATLQTPCPNCGGvvkenyrrfactkcDFsiskipggrqfeiaeveelLRKKEiGPlSGFRskMGRPFSAI 690
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 663 CKTTFPDKDGKP--DMEAKSRSEG----SMSRLEA--PCPSCSKEIIIRPKGFFC-------SGCEFKIWSEVSGKKLTQ 727
Cdd:PRK08173 691 LKLSDETKNYKLefDFGQDQGGEDgepvDFSAQEPvgACPKCGGRVFEHGMSYVCeksvgppKTCDFRSGKVILQQEISR 770
|
810 820 830 840
....*....|....*....|....*....|....*....|....*...
gi 2785401644 728 NQVETLIKKGKTGEIKGFTSNKTGKKFDAAIVLQDKatGKLGFQFSKK 775
Cdd:PRK08173 771 EQMAKLLADGKTDLLPGFKSSRTGRNFKAYLVKQPD--GKIGFEFEPR 816
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
1-620 |
9.84e-109 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 342.46 E-value: 9.84e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 1 MRLFIAEKPSLAKAIFEGLGgnpntekkNGYfehgsdVVTWCYGHMLELYDPE-DYDEKYsNWRfsdlpiksvypPQYKI 79
Cdd:COG0550 1 KKLVIVESPAKAKTIAKYLG--------KDY------VVTASVGHLRDLPKPElDVDVEN-DFE-----------PKYEV 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 80 KPESEAQTRIILSLIDKADNIVHAGDPDEEGCLLVDEILGYAKNTKSVYRLLVRDLNLAPVQKALTDLQPNDkfRGMTLS 159
Cdd:COG0550 55 IPGKKKQVKELKKLAKKADEVILATDPDREGEAIAWHLLELLGDKKPVKRVVFNEITKKAIKEAFKNPRDID--MNLVDA 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 160 ALARSLCDQGFGYNMTRGCTLKGREKgydgvLNVGRVQSAVLGLVNMRTLANQNHTESFYYDVFASLLMNGHLIKAKYQT 239
Cdd:COG0550 133 QQARRILDRLVGYNLSPLLWKKVKRG-----LSAGRVQSPALRLIVEREREIEAFVPEEYWTIEATFKTGGGEFTAKLVK 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 240 TDddqideKKRLISEAQAAHIAGRVTGKDAVVTIATTKPENTKPPLPLNLSTLQQLCAKRFGYSAKDTLDVMQGLYEThK 319
Cdd:COG0550 208 ID------GKKILDEEEAEAILAALKGKTFTVTSVEKKPKKRNPPPPFTTSTLQQEASRKLGFSAKKTMSIAQRLYEV-G 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 320 LLTYPRSDNRYLSDEhyyqagdiataIAATVPELASAIADMD-KSQKHKAFNASK--IEAHHAIIPTTKSGAGIQLNEKE 396
Cdd:COG0550 281 LITYMRTDSVRLSED-----------AVAAAREYIEALYGKEyLPEKPRVYKTSKnaQEAHEAIRPTGVTRTPESLSGDE 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 397 RNVYNLVSVYFIGLFYPDAIRNKTKIHFDIKGDTFTATQSVLVQKGWEALgkdnDDEDETEDAGTDGFDLSSLKFNDSGL 476
Cdd:COG0550 350 FKLYDLIWKRFLASQMPPAEYETTTVTIEVGGEEFRASGKVIKFPGFLKV----YGEGKDDEEEEEEKRLPPLKEGEKLK 425
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 477 CESADVDKKKTNPPRYFTASTLLAAMtsaakfiddpalrkaleakdegsEDRGsIGTEATRAGILEKLaANTGLISIEKe 556
Cdd:COG0550 426 LKKIEPEQHFTKPPPRYTEASLVKAM-----------------------EELG-IGRPSTYASIIETL-QDRGYVEREG- 479
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2785401644 557 kgySELVwkTTKQGQEFCAALP---PEITKPDISALWAEKQSQIKAGELTVEEFIKENDEYVQGLID 620
Cdd:COG0550 480 ---KRLV--PTELGFIVIDLLEehfPDLVDYEFTAKMEEKLDEIAEGKLDWKDVLEEFYKPFKELVE 541
|
|
| PRK14724 |
PRK14724 |
DNA topoisomerase III; Provisional |
3-775 |
4.65e-95 |
|
DNA topoisomerase III; Provisional
Pssm-ID: 237803 [Multi-domain] Cd Length: 987 Bit Score: 318.05 E-value: 4.65e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 3 LFIAEKPSLAKAIFEGLggNPNT---EKKNGYFEHGSDVVTWCYGHMLELYDPEDYDEKYSNWRFSDLPiksVYPPQYKI 79
Cdd:PRK14724 4 LVIAEKPSVAQDIVRAL--TPVAgkfEKHDEHFESDSYVVTSAVGHLVEIQAPEEFDVKRGKWSFANLP---VIPPYFDL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 80 KPESEAQTRI--ILSLIDKAD--NIVHAGDPDEEGCLLVDEILGYAKNTKS-----VYRLLVRDLNLAPVQKALTDLQPN 150
Cdd:PRK14724 79 KPVDKTKTRLnaVVKLAKRKDvtELVNACDAGREGELIFRLIEQYAGGAKGglgkpVKRLWLQSMTPQAIRDGFDNLRSD 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 151 DKFRGMTLSALARSLCDQGFGYNMTRGCT-LKGREKGYdGVLNVGRVQSAVLGLVNMRTLANQNHTESFYYDVFASLLMN 229
Cdd:PRK14724 159 AQMQGLASAARSRSEADWLVGINGTRAMTaFNSRDGGF-FLTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEIHAGFHAE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 230 -----GHLIKAKYQTTDDDQIDEKKRLISEAQAAHIAGRVTGKDAVVTiATTKPENTKPPLPLNLSTLQQLCAKRFGYSA 304
Cdd:PRK14724 238 ageylGKWFDPQWKKASDDPEARADRVWSEREARAIADAVRGKAATVT-EESKPTTQASPLLFDLTSLQREANGKFGFSA 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 305 KDTLDVMQGLYETHKLLTYPRSDNRYLSDEHYYQAGDIATAIAAT-----VPELASAIADMDKSQKHKAFNASKIEAHHA 379
Cdd:PRK14724 317 KTTLALAQSLYERHKALTYPRTDSRALPEDYLPVAKQTFEMLATSgmrhlAPFAQQALDGNYVRPSKRIFDNSKVSDHFA 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 380 IIPTTKSGAGiqLNEKERNVYNLVSVYFIGLFYPDAIRNKTKIHFDIKGDTFTATQSVLVQKGWEAL-GKDNDDEDETED 458
Cdd:PRK14724 397 IIPTTQAPSG--LSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISQVVGHSFKTEGKVLVKPGWLAIyGKEAANEVEDAK 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 459 AGTDGFDLSSLKFNDSGLCESADVDKKKTNPPRYFTASTLLAAMTSAAKFIDDPALRKALEAKdegsedrgSIGTEATRA 538
Cdd:PRK14724 475 DGDKGQPLVPVKPGEMVRTEFAEAKGLKTKPPARYSEATLLGAMESAGKQIDDDELREAMQEK--------GLGTPATRA 546
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 539 GILEKLAANTGLIS-----IEKEKGYSELvwkTTKQGQEFcaalpPEITKPDISALWAEKQSQIKAGELTVEEFIKENDE 613
Cdd:PRK14724 547 AIIEGLLTEKYMLRegrelIPTAKAFQLM---TLLRGLGV-----EELSRAELTGEWEYKLAQMEKGQLSREAFMQQIAA 618
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 614 YVQGLID---ELERNGV--SISSNATPCPVCnNGFLRKR------KGQNGFFWGC----SCYPECKT------------- 665
Cdd:PRK14724 619 MTEKLVKkakEYDRDTIpgDYATLSTPCPNC-GGVVKENyrryacTGANGAGEGCgfsfTKSPAGRTfetaeaeqllrdr 697
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 666 ------TFPDKDGKP---DMEAKSRSEGSMSRLE------------------------APCPSCSKEIIIRPKGFFCS-- 710
Cdd:PRK14724 698 rigpleGFRSKAGWPftaEVVIKRDEEAKNYKLEfdfgddknaedtgeivdfagqeslGPCPKCGAPVFEHGSNYVCEks 777
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2785401644 711 ---------GCEFKIWSEVSGKKLTQNQVETLIKKGKTGEIKGFTSNKTGKKFDAAIVLqDKATGKLGFQFSKK 775
Cdd:PRK14724 778 vptlaqptpSCTFKSGQVILQQPIEREQMQKLLATGKTDLLDKFVSMRTRRAFKAFLAW-DKEAGKVNFEFEPR 850
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
151-609 |
1.22e-90 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 290.68 E-value: 1.22e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 151 DKFRGMTLSALARSLCDQGFGYNMTRGCTLKgreKGYDGVLNVGRVQSAVLGLVNMRTLANQNHTESFYYDVFASLLMNG 230
Cdd:pfam01131 1 EIDENLVDAQLARRELDWLIGFNLSRLLTLK---LKGNKLLSAGRVQTPTLALIVEREREIENFVPEPYWTIEATLKDGG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 231 HLIKAKYqttdddqiDEKKRLISEAQAAHIAGRVTGKDAVVTIATTKPENTKPPLPLNLSTLQQLCAKRFGYSAKDTLDV 310
Cdd:pfam01131 78 GVFANAK--------WKRGRIFDKEEAEAILEKLKKGTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSI 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 311 MQGLYETHKLLTYPRSDNRYLSDEhyYQAGDIATAIAATVPELASAIADMDKSQKHKA-FNASKIEAHHAIIPTTKSGAG 389
Cdd:pfam01131 150 AQKLYEKHGLITYPRTDSTYLSDD--ATLKAILEYLTKNYGKYLPYAPRLLKKTKGKLtVGNAKVTAHEAIRPTGDIPVL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 390 IQLNEKERNVYNLVSVYFIGLFYPDAIRNKTKIHFDIKGDTFTATQSVLVQKGWEALGKDNDDEdetedagtDGFDLSSL 469
Cdd:pfam01131 228 PELSDDERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVYPYEKKE--------DEEELPEL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 470 KFNDSGLCESADVDKKKTNPPRYFTASTLLAAMtsaakfiddpalrkaleakdegsEDRGsIGTEATRAGILEKLaantg 549
Cdd:pfam01131 300 KEGEELKVTQVEVEEKKTKPPPRYTEASLIKAM-----------------------EKAG-IGTPATRATIIETL----- 350
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2785401644 550 lisieKEKGYSELVWKT---TKQGQEFCAALP--PEITKPDISALWAEKQSQIKAGELTVEEFIK 609
Cdd:pfam01131 351 -----LERGYVERKKKSlvpTELGKALVEALEkfPDLVDPELTAELEEKLDEIAEGKLDWKDVLA 410
|
|
| PRK07219 |
PRK07219 |
DNA topoisomerase I; Validated |
1-716 |
2.75e-70 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235971 [Multi-domain] Cd Length: 822 Bit Score: 246.84 E-value: 2.75e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 1 MRLFIAEKPSLAKAIFEGL-GGNPNTEKKNG--YFEHGSDVVTWCY----GHMLELydpeDYDEKYSNWRFSDLPIKSVY 73
Cdd:PRK07219 1 TELIIAEKNNAARRIADILsGGKAKKKRVNGvpYYEFERKGEKWIViglsGHIVTV----DFPEEYGDWRDVDPAELIDA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 74 PPQYKIKPESEAQTriILSLIDKADNIVHAGDPDEEGCLLVDEILGYAKNTKSVYRLLVRDLNLAP--VQKALTDlqPND 151
Cdd:PRK07219 77 DPVKKITKQNYINA--LKKLAKDADEIIIATDYDREGELIGKEAYHILREVCQVPVKRARFSSLTKkeIRKAFEN--PDE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 152 KFRGMTLSALARSLCDQGFGYNMTRGCTLKGREKGYDGVLNVGRVQSAVLGLVNMRTLANQNHTESFYYDVFASLLMNgh 231
Cdd:PRK07219 153 IDFNLADAGEARQIIDLYWGAALTRFLSLSVRQLGRWDFLSVGRVQTPTLAFIVDREREIRAFDPEDYWKIEALLDKE-- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 232 likAKYQTTDDDQIDEKKRLISEAQAAHIAGRVTG-KDAVVTIATTKPENTKPPLPLNLSTLQQLCAKRFGYSAKDTLDV 310
Cdd:PRK07219 231 ---AQYFYRDLIGGHEAEKFWDEEEAEEIYEKLKGaKEATVSSVKKRERTISPPAPFNTTEFLREASKIFGISPKRAMEI 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 311 MQGLYeTHKLLTYPRSDNRYLSDEHyyqagDIATAIAATV--PELASAIADMDKSQKHKAFNAsKIEAH-HAIIPTTKSG 387
Cdd:PRK07219 308 AEKLY-TAGYISYPRTDNTVYPDDL-----DPKELLKKLSkkKEYGPYAESILEQENIKPTEG-KKETTdHPPIHPVDVP 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 388 AGIQLNEKERNVYNLVSVYFIGLFYPDAIRNKTKIHFDIKGDTFTATQSVLVQKGWEALGKDNDdedetedagTDGFDLS 467
Cdd:PRK07219 381 KREELSDDEWKVYELIVRRFLATLADPAEWEYLKVELDVNGEIFKASGSRLVEEGWHEVYPYEK---------FDEKELP 451
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 468 SLKFNDSGLCESADVDKKKTNPPRYFTASTLLAAMtsaakfiddpalrkaleakdegsEDRGsIGTEATRAGILEKLaan 547
Cdd:PRK07219 452 DLEEGEKLKVNKIEIEAKETQPPKRYTQSSLIKEM-----------------------EKRG-LGTKATRHDIIEKL--- 504
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 548 tglisieKEKGY---------SELVWKTTKQGQEFCaalpPEITKPDISALWAEKQSQIKAGELTVEEFIKENDEYVQGL 618
Cdd:PRK07219 505 -------YKRGYviegdpprpTDLGIAVIEALEKYA----PEIVSEEMTAQLEADMQAIEDGKKKKEDVTEESREMLKEI 573
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 619 IDELERNGVSISS------NAT--------PCPVCNNGFLRKRKGQNGFFWGCSCYPECKTTFPDKdgkpdmeaksrSEG 684
Cdd:PRK07219 574 LSELKEKRKEIGDhlagslKAEnrslktigKCPECGGDLIIIRTDKGSRFVGCSGYPDCRNTFPLP-----------STG 642
|
730 740 750
....*....|....*....|....*....|....*..
gi 2785401644 685 SMSRLEAPCPSCSKEII--IRPKGFF---CSGCEFKI 716
Cdd:PRK07219 643 RIKVLDEVCEKCGLPVIkiLRGKQTFvvgCPDCEAEK 679
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
277-559 |
6.80e-53 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 183.99 E-value: 6.80e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 277 KPENTKPPLPLNLSTLQQLCAKRFGYSAKDTLDVMQGLYEtHKLLTYPRSDNRYLSDEHYYQAgdiATAIAATVPELASA 356
Cdd:smart00437 3 KEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYE-KGLITYPRTDSTRLSEEAVLEA---RNYIQKLYGKEYLD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 357 IADMDKSQKHKAFNASKIEAHHAIIPT---TKSGAGIQLNEKERNVYNLVSVYFIGLFYPDAIRNKTKIHFDIKGDTFTA 433
Cdd:smart00437 79 LAVVLLKPRKPRKGKKAQGAHEAIRPTkpiFTPELEKELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFKA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 434 TQSVLVQKGWEALGKDNDDedetedagTDGFDLSSLKFNDSGLCESADVDKKKTNPPRYFTASTLLAAMtsaakfiddpa 513
Cdd:smart00437 159 KGKTLLFDGWLKVYPEEKK--------EEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLM----------- 219
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 2785401644 514 lrkaleakdegsEDRGsIGTEATRAGILEKLaantglisieKEKGY 559
Cdd:smart00437 220 ------------EKRG-IGRPSTYASIIETL----------LDRGY 242
|
|
| topA_arch |
TIGR01057 |
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These ... |
5-663 |
1.07e-49 |
|
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These enzymes are involved in the control of DNA topology. DNA topoisomerase I belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273420 [Multi-domain] Cd Length: 618 Bit Score: 185.03 E-value: 1.07e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 5 IAEKPSLAKAIFEGLGGNPNTEKKNG---YFEHGSD----VVTWCYGHMLELYdpEDYDEKYSNWRFSDLPI-----KSV 72
Cdd:TIGR01057 1 IAEKPKVAAKIAGALSDGRVLKKSEYgvpYWEVRRDgkkiIVASAVGHLFGLH--PKSRGGYPVFDIEWVPIfefdkGKG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 73 YPPQYkikpeseaqTRIILSLIDKADNIVHAGDPDEEGCLLVDEILGYAKNTKSVYRLLVRDLNLAPVQKALTDLQPNDk 152
Cdd:TIGR01057 79 YVSKY---------IKALSKLAKGADEYINACDYDIEGEVIGFKALKYFCGVERAKRMKFSTLTKQDIRRAYANPEEID- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 153 fRGMTLSALARSLCDQGFGYNMTRGCTLKGRE-KGYDGVLNVGRVQSAVLGLVNMRTLANQNHTESFYYDVFASLLMNGH 231
Cdd:TIGR01057 149 -YGMVDAGMARHILDWYWGINLSRALMEAIRAaAGRWVILSAGRVQGPTLAFLVEREREINLFVPKPYWVIKATLEKGGG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 232 LIKAKYQTTDDDQIDEKKRLISEAQAAHIAgrvtgkdAVVTIATTKpENTKPPLPLNLSTLQQLCAKRFGYSAKDTLDVM 311
Cdd:TIGR01057 228 VFDARPEKWKIWSEEEAKSIKEELKKSPWA-------AVEEVRSER-SILKPPPPFDLGTLQREAYRIFGFSPKKTQSIA 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 312 QGLYEtHKLLTYPRSDNRYLSDEHYYQAgdIATAIAATvPELASAIADMDKSQKHKAFNASKIE-AHHAIIPTTKSGAGi 390
Cdd:TIGR01057 300 QELYE-EALISYPRTSSQKLPPSINYRA--ILDNLAKG-PLYREAAERLLETGVLKPVEGKKEDpAHPAIHPTGEIPSQ- 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 391 QLNEKERNVYNLVSVYFIGLFYPDAIRNKTKIHFDIKGDTFTATQSVLVQKGWEALGKDNDDedetedagtDGFDLSSLK 470
Cdd:TIGR01057 375 ELSKDEKKVYDLIVRRFLAAFSEEAIREKSKVLLRIGQEKFRLSGLRVVKLGWLEYYHYSKF---------EEKELPPLD 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 471 FNDSGLCESADVDKKKTNPPRYFTASTLLAAMtsaakfiddpalrkaleakdegsEDRGsIGTEATRAGILEKLAaNTGL 550
Cdd:TIGR01057 446 RGDKIKVVRVDVRVKETQPPARYDKASLIREM-----------------------ESRG-LGTKATRARIIETLY-KRGY 500
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 551 ISIEKEKGYSELVWKTTKQGQEFCaalpPEITKPDISALWAEKQSQIKAGELTVEEFIKENDEYVQGLIDELERN----G 626
Cdd:TIGR01057 501 IEGKKSIKVTPLGEAVIETLQRYC----PEIISEELTRRFESKLEDIMSGRITKDEVIDEAKKRLRKILEEFKKRlddiG 576
|
650 660 670 680
....*....|....*....|....*....|....*....|...
gi 2785401644 627 VSISSN------ATPCPVCNNGFLRKRKgQNGFFWGCSCYPEC 663
Cdd:TIGR01057 577 IELGKSlgsvevVGKCPKCGGKLVSKYA-KKGRFVGCSNYPEC 618
|
|
| PRK05776 |
PRK05776 |
DNA topoisomerase I; Provisional |
3-671 |
4.83e-46 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 235602 [Multi-domain] Cd Length: 670 Bit Score: 175.18 E-value: 4.83e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 3 LFIAEKPSLAKAIFEGLGGNPNTEKKNG--YFE----HGSDVVTWCYGHMLELYDPE------DYDekysnWRfsdlpik 70
Cdd:PRK05776 4 LVIAEKPKAARKIAEALSEKPIRCRIYGvpYWIvkrdGKKIVVAPAAGHLFGLHTKSkgfpvfDYE-----WK------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 71 svypPQYKIKPESeAQTR----IILSLIDKADNIVHAGDPDEEGCLLVDEILGYAKNTKSVYRLLVRDLNLAPVQKALTD 146
Cdd:PRK05776 72 ----PLYEIDKGS-KYTKkyyeLLSSLSKYADEFINACDYDIEGSVIGYLIIKYLGDPKKAKRMKFSALTKSDIRRAFRN 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 147 LQPNDkfRGMTLSALARSLCDQGFGYNMTRGCTLKGRE-KGYDGVLNVGRVQSAVLGLVNMRTLANQNHTESFYYDVFAS 225
Cdd:PRK05776 147 LETLD--YEMINAGIARHELDWLWGINVSRALMSSVRDaSGKRVILSAGRVQSPTLKYVVEREIERNLFVPLPYFSVSII 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 226 LLMNGHLIKAKYqttdddqidEKKRLISEAQAAHIAGRVTG-KDAVVTIATTKPENTKPPLPLNLSTLQQLCAKRFGYSA 304
Cdd:PRK05776 225 IEKNGYEFTLKY---------ENKKFETKEEAKEILEEIKKtGYLKVTKVEVKIEILEPPPPFNLGDLQVEAARIYGFSP 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 305 KDTLDVMQGLYEtHKLLTYPRSDNRYL-SDEHYYQagdIATAIAAtVPELASAIADMDKSQK--HKAFNASKIE-AHHAI 380
Cdd:PRK05776 296 YKTQSIAEDLYL-DGLISYPRTNSQKLpPTLNIRN---ILKGLSR-SPQYRPLVNLLLKETKgvLKPVQGPKDDpAHPAI 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 381 IPTTKSGAgiQLNEKERNVYNLVSVYFIGLFYPDAIRNKTKIHFDIKGD--TFTATQSVLVQKGWEALGKDNDDedeted 458
Cdd:PRK05776 371 YPTGEPPK--NLSKDEFKLYDLIVRRFLASFAAPAVLSNTIVTLRVPGFplVFSASGQRIEERGWLKYYPFHKF------ 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 459 agtDGFDLSSLKFNDSGLCESADVDKKKTNPPRYFTASTLLAAMtsaakfiddpalrkaleakdegsEDRGsIGTEATRA 538
Cdd:PRK05776 443 ---DEEELPLLKKGERVKIVDVKVRKSYTKPPSRYSKASLLKWM-----------------------ESVG-IGTEATRA 495
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 539 GILEKLAANTGLISIEKEKGYSELVWKTTKQGQEFCaalpPEITKPDISALWAEKQSQIKAGELTVEEFIKENDEYVQGL 618
Cdd:PRK05776 496 RIIETLFKRGYLTSNGKYIEVTPLGFGVAEVLEKYF----PDIVSVELTRDFEEKLEMIRTGKATREEVIEEAKETLNKL 571
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2785401644 619 IDELERN----GVSISS------NATPCPVCN-----NGFLRKRKGQNGFFWGCSCYPECKTTFPDKD 671
Cdd:PRK05776 572 LEEFKKNkdeiGEELAKalglikPVGKCKICGreaykDGLCKYHYEAKKRLVKAYEEWKERTGYDHKE 639
|
|
| PRK07220 |
PRK07220 |
DNA topoisomerase I; Validated |
1-759 |
6.17e-45 |
|
DNA topoisomerase I; Validated
Pssm-ID: 180892 [Multi-domain] Cd Length: 740 Bit Score: 172.63 E-value: 6.17e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 1 MRLFIAEKPSLAKAIFEGL-GGNPNTEKKNG-----YFEHGSD-VVTWCYGHMLELydpeDYDEKYSNWRFSDlpIKSVY 73
Cdd:PRK07220 1 MHLIITEKNIAARRIAQILaPKKPKKTRVSGvdvyrYEDNGDDtVVVGLSGHIVNI----DFPKEYNNWQKVD--ARDLI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 74 PPQYKIKPESEAQTRIILSLIDKADNIVHAGDPDEEGCLLVDEILGYAKNTK---SVYRLLVRDLNLAPVQKALTDLQPN 150
Cdd:PRK07220 75 DAEIITTPTQKKIVTALKKLGKEADRVTIATDYDREGELIGVEALNIIKKVNpdiKFDRVRYSAITKKEIERAFSNPVEV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 151 DkfRGMTLSALARSLCDQGFGYNMTRGCTLKGREKGyDGVLNVGRVQSAVLGLVNMRTLANQNHTESFYYDVFASLLMNG 230
Cdd:PRK07220 155 D--FNLADAGHSRQVIDLVWGAALTRYISLAAGRLG-KMFLSVGRVQSPTLALIVDREKEREAFVPTPYWEIYATLENNG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 231 HLIKAKYQTTdddqidekkRLISEAQAAHIAgRVTGKDAVVTIATTKPENTKPPLPLNlSTLQQLCAKRFGYSAKDTLDV 310
Cdd:PRK07220 232 ETFVAQHSTR---------RFWEKEEADRVF-EKLGKTAEVTEVEKGTKTDKPPTPFN-TTEFISAANSIGFSAANAMRI 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 311 MQGLYeTHKLLTYPRSDNRYlsdehYYQAGDIATAIA----ATVPELASAIadMDKSQKHKAFNASKIEAHHAIIPTTkS 386
Cdd:PRK07220 301 AESLY-TNGYISYPRTDNTV-----YPESLDLREQIEifaeGPFGEYAQKL--LEKGELVPTRGKKETTDHPPIYPAS-L 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 387 GAGIQLNEKERNVYNLVSVYFIGLFYPDAIRNKTKIHFDIKGDTFTATQSVLVQKGWEALGKDNDDEDETedagtdgfdL 466
Cdd:PRK07220 372 AKKSELKEDEWKVYELVVRRFFATFAGPAEWETMKLRFDIGGEEFRANGSRLTEPGWRWYYPYNAPEDRL---------L 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 467 SSLKFNDSGLCESADVDKKKTNPPRYFTASTLLAAMtsaakfiddpalrkaleakdegsEDRGsIGTEATRAGILEKLAA 546
Cdd:PRK07220 443 PELSEGEELKVKKKEMLDKETQPPGRYGQGRLIKLM-----------------------EDLG-LGTKATRHEIISKLYS 498
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 547 ------------NTGLISIEKEKGYSelvwkttkqgqefcaalpPEITKPDISALWAEKQSQIKAGELTVEEFIKENDEY 614
Cdd:PRK07220 499 rayihgnpiqptNTAFAVVDALEKYA------------------PTITKPDMTSRLEEDMDKIAEGKIKEDAVLEESREM 560
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 615 VQGLIDELE----------RNGVSISSNATPCPVCNNGFLRKRKGQNGFFWGCSCYPECKTTFPdkdgKPDMeaksrseG 684
Cdd:PRK07220 561 LEQVFDELDknrekireslREGLREDKIIGKCPLCGSDLMVRRSKRGSRFIGCEGYPECTFSLP----LPKS-------G 629
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 685 SMSRLEAPCPSCS-KEIII-----RPKGFFCSGCEFKIWSEVSGKKLTQnQVETLIKKGKTgEIKGFTSNKTGKKFDAAI 758
Cdd:PRK07220 630 QIIVTDKVCEAHGlNHIRIinggkRPWDLGCPQCNFIEWQKKQKEEKAQ-QPKKEKPKSIK-DIKGIGKKTAEKLEEAGI 707
|
.
gi 2785401644 759 V 759
Cdd:PRK07220 708 T 708
|
|
| PRK14973 |
PRK14973 |
DNA topoisomerase I; Provisional |
1-664 |
1.38e-42 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 184936 [Multi-domain] Cd Length: 936 Bit Score: 166.95 E-value: 1.38e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 1 MRLFIAEKPSLAKAIFEGLGGNPNTE-KKNGYFEH---GSDVVTWCYGHMLELydpeDYDEKYSNWRFSDLPIKSVYPPQ 76
Cdd:PRK14973 1 MHLIIAEKNIAANRIAQILAGKTKVQvKKDGGVSTysfDDTVVVGLRGHVVEV----DFEPGYTNWRSEEHTPRSLIDAD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 77 YKIKPESEAQTRIILSLIDKADNIVHAGDPDEEGcllvdEILGyakntKSVYRLlVRDLNL-APVQK----ALTDLQPND 151
Cdd:PRK14973 77 TIKKPTEKKIVGLIQKLAKKADRVTIATDFDTEG-----ELIG-----KEAYEL-VRAVNPkVPIDRarfsAITKEEIVT 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 152 KFRGMT-----LSAL--ARSLCDQGFGYNMTRGCTLKGReKGYDGVLNVGRVQSAVLGLVNMRtlanQNHTESF----YY 220
Cdd:PRK14973 146 AFAEPTdldfaLAAAgeARQIIDLIWGASLTRFISLAAH-RGGDNILSVGRVQSPTLAMIVDR----EKEIEAFvpekYW 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 221 DVFASLLMNGHLIKAKYQT---TDddqidekkrlISEAQAAHIAgrvTGKDAVVTIATTKPENTKPPLPLNLSTLQqLCA 297
Cdd:PRK14973 221 MLSLATEKDGEGIEARHTHgrfTD----------SAAAEAAYDA---TKEPLVVTEVKEGHKVDRAPTPFDTTTFI-VAA 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 298 KRFGYSAKDTLDVMQGLYeTHKLLTYPRSDNRYlsdehYYQAGDIaTAIAATVP--ELASAIADMDKSQKHKAFNASKIE 375
Cdd:PRK14973 287 SRLGFSAANAMRIAEDLY-MNGYISYPRTDNTI-----YPKSLDL-NGVLATLAkgAFSKDVAWVKDNRRPVPTRGKKSS 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 376 AHHAIIPTTKSGAGIQLNEKERNVYNLVSVYFIGLFYPDAIRNKTKIHFDIKGDTFTATQSVLVQKGWEALGKDNDDEDE 455
Cdd:PRK14973 360 TDHPPIHPTGVATREELGDDRWKLYELVVRRFLATLSPDAEWATMKVNFDAGGEPYTATGGRLLEAGWRTVYPYSEAKEN 439
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 456 TEDAGTDGFDLSSLKFNdsglcesadVDKKKTNPPRYFTASTLLAAMtsaakfiddpalrkaleakdegsEDRGsIGTEA 535
Cdd:PRK14973 440 ILPAFALGEKLPILAVN---------LEEKETQPPARYSQSRLIQRM-----------------------EELG-LGTKS 486
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 536 TRAGILEKLaanTGLISIEKEKGYSELVWKTTKQGQEFCAAlppEITKPDISALWAEKQSQIKAGELTVEEFIKENDEYV 615
Cdd:PRK14973 487 TRHEVIGKL---VSRKYIEGNPLRPTLVGRAVTESLEEHAG---TITEPDMTQTLEEHMQQIKERKRTRDDVVTESRKML 560
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*....
gi 2785401644 616 QGLIDELERNGVSISS----------NATPCPVCNNGFLRKRKGQNGFFwGCSCYPECK 664
Cdd:PRK14973 561 HRAFDELEANEAVIGRdimertaeelTIGPCPVCGKDLRIKHIGSSQFI-GCSGYPDCT 618
|
|
| TOPRIM_TopoIA_TopoIII |
cd03362 |
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type ... |
1-147 |
1.76e-38 |
|
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173782 [Multi-domain] Cd Length: 151 Bit Score: 140.06 E-value: 1.76e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 1 MRLFIAEKPSLAKAIFEGLGGNPNTEKK--NGYFEHGSD--VVTWCYGHMLELYDPEDYDEKYSNWRFSDLPIKSvyPPQ 76
Cdd:cd03362 1 MVLIIAEKPSVAKAIAKILGGGSKKKGKgrYYEFYGEGGgyVVTWASGHLLELDFPEEYDPWDKVWPLEDPLFPA--PFK 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2785401644 77 YKIKPESEAQTRIILSLIDKADNIVHAGDPDEEGCLLVDEILGYAKN--TKSVYRLLVRDLNLAPVQKALTDL 147
Cdd:cd03362 79 LKVDKGKKKQFKVLKKLAKRADEIVIATDADREGELIGREILEYAKCvkRKPVKRAWFSSLTPKAIRRAFKNL 151
|
|
| PRK06599 |
PRK06599 |
DNA topoisomerase I; Validated |
1-711 |
8.42e-34 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235840 [Multi-domain] Cd Length: 675 Bit Score: 138.45 E-value: 8.42e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 1 MRLFIAEKPSLAKAIFEGLGGNpntekkngyFEhgsdvVTWCYGHMlelydpedydekysnwrfSDLPIK--SV-----Y 73
Cdd:PRK06599 3 KKLVIVESPAKAKTIKKYLGKD---------YK-----VLASFGHV------------------RDLPKKkgGVdpdndF 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 74 PPQYKIKPESEAQTRIILSLIDKADNIVHAGDPDEEGCLL---VDEILGYAKNT-KSVYRLLVRDLNLAPVQKALTdlQP 149
Cdd:PRK06599 51 APKYEIIEGKEKVVDALKKAAKKADAVYLATDPDREGEAIawhIAEVLKEAKLKdKNVKRVVFNEITKKAVQEAIE--NP 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 150 NDKFRGMTLSALARSLCDQGFGYNMT-------RGCtlkgrekgydgvLNVGRVQSAVLGLVNMRTLANQNHTESFYYDV 222
Cdd:PRK06599 129 RDIDMDLVDAQQARRALDYLVGFKLSpllwkkvRRG------------LSAGRVQSVALRLICEREDEIEAFIPQEYWTI 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 223 FASLL-MNGHLIKAKYQTTDDDQIdEKKRLISEAQAAHIAGRVTGKDAVVTIATTKPENTKPPLPLNLSTLQQLCAKRFG 301
Cdd:PRK06599 197 EADLAtSNGEPFTAKLVEVNGKKL-EKFSITNEEQAKALVKALEGQAYTVDKIEKKERKRNPPPPFITSTLQQEASRKLG 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 302 YSAKDTLDVMQGLYE-------THKLLTYPRSDNRYLSDEHYYQAGDIATAI--AATVPELAsaiadmdKSQKHKAFNAS 372
Cdd:PRK06599 276 FSAKKTMRIAQKLYEgidlgegTVGLITYMRTDSVRLSNEALDEARKYITKKygKEYLPAKP-------RVYKKKSKNAQ 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 373 kiEAHHAIIPT--TKSGAGIQ--LNEKERNVYNLVSVYFIGLFYPDAIRNKTKIHF-DIKGD-TFTATQSVLVQKGWEAL 446
Cdd:PRK06599 349 --EAHEAIRPTsiNRTPESLKpyLTPDQFKLYELIWKRTVASQMAPAILDQTSVDIaSENGKyVFRATGSVILFPGFLKV 426
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 447 GKDNDDEDETEDAGtdgfDLSSLKFNDSglCESADVDKKK--TNPP-RYFTAStllaamtsaakfiddpaLRKALEAKDe 523
Cdd:PRK06599 427 YGESKDDEEEDDEK----LLPPLKEGEK--LKLDELLPEQhfTEPPpRYSEAS-----------------LVKKLEEYG- 482
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 524 gsedrgsIGTEATRAGILEKLaantglisieKEKGYSELVWKT---TKQGQEFCAALP---PEITKPDISALWAEKQSQI 597
Cdd:PRK06599 483 -------IGRPSTYASIISTL----------QDREYVELEKKRfipTDLGRIVNDFLVehfPKYVDYDFTAGLEDELDEI 545
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 598 KAGELtveEFIKENDEYVQGLIDELE-RNGVSISSNAT------PCPVCNNGFLRKRKGQNGFFWGCSCYPECKTTFP-- 668
Cdd:PRK06599 546 AEGKK---DWKPVLREFWEPFISNLEkVEEDVRTEKVTqeetdeTCPKCGGGPLVLKLGKNGKFLGCSGYPECKYTKNit 622
|
730 740 750 760
....*....|....*....|....*....|....*....|....*....
gi 2785401644 669 -DKDGKPDMEAKSRSEGsmsrleapCPSCSKEIIIRpKGFF-----CSG 711
Cdd:PRK06599 623 rDEDEPIEEEEIVEEEK--------CPKCGGPLVLK-KGRYgkflaCSG 662
|
|
| TOPRIM_TopoIA |
cd01028 |
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
1-144 |
1.61e-32 |
|
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli topisomerases I and III, eukaryotic topoisomerase III and, ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA. These enzymes cleave one strand of the DNA duplex, covalently link to the 5' phosphoryl end of the DNA break and allow the other strand of the duplex to pass through the gap. Reverse gyrase is also able to insert positive supercoils in the presence of ATP and negative supercoils in the presence of AMPPNP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173778 [Multi-domain] Cd Length: 142 Bit Score: 122.72 E-value: 1.61e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 1 MRLFIAEKPSLAKAIFEGLGGNPNteKKNGYFEHGSDVVTWCYGHMLELYDPEDYDEKYSNWRFSDLPIksvyPPQYKIK 80
Cdd:cd01028 1 KVLIIAEKPSKAKTIAKILGKGSK--KKGFYGEGGGYVVTASVGHLLELPFPEEYVDWDKDWPLELFPF----EPKYVVI 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2785401644 81 PESEAQTRIILSLIDKADNIVHAGDPDEEGCLLVDEILGYAKN-TKSVYRLLVRDLNLAPVQKAL 144
Cdd:cd01028 75 PDKKKQLKALKKLAKKADEIVLATDPDREGELIAWEILEVLKCdNKPVKRAWFSEITPKAIREAF 139
|
|
| PRK06319 |
PRK06319 |
DNA topoisomerase I/SWI domain fusion protein; Validated |
66-713 |
1.32e-24 |
|
DNA topoisomerase I/SWI domain fusion protein; Validated
Pssm-ID: 235778 [Multi-domain] Cd Length: 860 Bit Score: 110.30 E-value: 1.32e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 66 DLP-------IKSVYPPQYKIKPESEAQTRIILSLIDKADNIVHAGDPDEEGCLLVDEILG-YAKNTKsVYRLLVRDLNL 137
Cdd:PRK06319 36 DLPakefgidIENDFEPDYQILPDKEEVINKICKLAKKCDVVYLSPDPDREGEAIAWHIANqLPKNTK-IQRISFNAITK 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 138 APVQKALTdlQPNDKFRGMTLSALARSLCDQGFGYNMTrgcTLKGREKGYDGVLNVGRVQSAVLGLVNMRTLANQNHTES 217
Cdd:PRK06319 115 GAVTEALK--HPREIDMALVNAQQARRLLDRIVGYKIS---PILSRKLQRRSGVSAGRVQSVALKLVVDREKAIEAFVPV 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 218 FYYDVFASL-------LMNGHLIKAKYQTTDDDQIDEKKR----LI-SEAQAAHIAGRVTGKDAVVTIATTKPENTKPPL 285
Cdd:PRK06319 190 EYWNIRVHLkdpktqkTFWAHLYSVDGKKWEKEIPEGKTEdevlLInSKEKADHIVELLESATYTVTRVESKEKRRNAYP 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 286 PLNLSTLQQLCAKRFGYSAKDTLDVMQGLYE--------THKLLTYPRSDNRYLSDEHYYQAGDIataIAAT-----VPE 352
Cdd:PRK06319 270 PFITSTLQQEASRHFRFSSSRTMNIAQTLYEgvdldsegATGLITYMRTDSVRTDPEALKQVRKY---IEGTfgkefLPS 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 353 LASAIADMDKSQkhkafnaskiEAHHAIIPT----TKSGAGIQLNEKERNVYNLVSVYFIGLFYPDAIRNKTKIhfDIKG 428
Cdd:PRK06319 347 SPNVYTTKKMAQ----------DAHEAIRPTditlTPEKLRSKLTEDQYKLYSLIWKRFVASQMIPAIYDTLAI--RITT 414
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 429 DT---FTATQSVLVQKGWEALgkdNDDEDETEDAGTDGFDLSSLKFNDSGLCESADVDKKKTNPPRYFTASTLLaamtsa 505
Cdd:PRK06319 415 NKgidLRATGSLLKFKGFLAV---YEEKRDDEGDEEENIHLPKLHEQDVLTKEELSAEQAFTKPLPRFTEASLV------ 485
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 506 akfiddpalrKALEakdegsedRGSIGTEATRAGILEKLAANTGLIsieKEKGYselvWKTTKQGQEFCAALP---PEIT 582
Cdd:PRK06319 486 ----------KELE--------KSGIGRPSTYATIMNKIQSREYTL---KENQR----LRPTELGKIISQFLEtnfPRIM 540
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 583 KPDISALWAEKQSQIKAGELTVEEFIKENDEYVQGLIDELERNGV--SISSNATpCPVCNNGFLRKRKGQNGFFWGCSCY 660
Cdd:PRK06319 541 DIGFTALMEDELELIADNKKPWKLLLQEFWELFLPVVVTAEKEAFipRIVTEID-CPKCHKGKLVKIWAKNRYFYGCSEY 619
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*
gi 2785401644 661 PECKTTFPDKDGKPDMEAKSRSegsmSRLEAPCPSCSKEIIIRpKGFFCS--GCE 713
Cdd:PRK06319 620 PECDYKTSEEELTFNKEDYAED----TPWDSPCPLCGGEMKVR-HGRFGTflGCE 669
|
|
| YrdD |
COG0551 |
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ... |
233-740 |
3.06e-20 |
|
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];
Pssm-ID: 440317 [Multi-domain] Cd Length: 695 Bit Score: 95.70 E-value: 3.06e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 233 IKAKYQTTDDDQIDEKKRLISEAQAAHIAGRVTGKDAVVTIATTKPENTKPPLPLNLSTLQQLCAKRFGYSAKDTLDVMQ 312
Cdd:COG0551 215 KKEEDKKKKKKKKKKDKEEETKAIKKKKKAAEAVLAAKKAAKEAKAKKELPTTTTDALPEALATTSLTAAAAASALAAAL 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 313 GLYETHKLLTYPRSDNRYLSDEHYYQAGDIATAIAATVPELASAIADMDKSQKHK--AFNASKIEAHHAIIPTTKSGAGI 390
Cdd:COG0551 295 LEEEGELLYTGGYIRYTRTPKSSEADALAALEALKKIAEEPPDERAKKKKKKAKKkkASEAKETTDHPPIPPTTAAALLE 374
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 391 QLNEKERNVYNLVSVYFIGLFYPDAIRNKTKIHFDIKGDTFTATQSVLVQKGWEALGKDNDDEDETEDAGTDGFDLSSLK 470
Cdd:COG0551 375 LLEDRKLLLELLVRRRFAAAADLAKVEELTKVEEADEEELVEAEGGLLEVLGEEEEDDEDEEEELLLPPLEEGEPLLLEE 454
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 471 FNDSglcesadvdKKKTNPPRYFTASTLLAAMTsaakfiddpalrkaleakdegsedRGSIGTEATRAGILEKLAANTGL 550
Cdd:COG0551 455 LLLE---------KQTTTPPPRYTTELLLKKLE------------------------EEGGGGRGTTATIIILILKRRYV 501
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 551 ISIEKEKgyseLVWKTTKQGQEFCAALPPEITKPDISALWAEKQSQIKAGELTVEEFIKENDEYVQGLIDELERNGV--- 627
Cdd:COG0551 502 VLEEKKT----TPTELLVEVVLLLLLPFPKLEDTTETAEEEEALLDKEEGKEDKVVEIREEEYPFFKKLLEIAEEEGeee 577
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 628 -SISSNAT--PCPVCNnGFLRKRKGQNGFFWGCSCYPECKTTFPDKDGKpdmeaksrsegsmsRLEAPCPSCSKEIIIR- 703
Cdd:COG0551 578 lSEEDEVLgeKCPKCG-KPLVIKKGRYGKFLGCSNYPECKYTKPLPKPE--------------VTGVKCPKCGKKLVLRk 642
|
490 500 510 520
....*....|....*....|....*....|....*....|....
gi 2785401644 704 -PKG---FFCSG---CEFKIWSEVSGKKLTQNQVETLIKKGKTG 740
Cdd:COG0551 643 sKKGkvfYGCSNypkCKFTEWDKPVKEPCPKCGSPLVEKKTKKG 686
|
|
| PRK07561 |
PRK07561 |
DNA topoisomerase I subunit omega; Validated |
1-666 |
6.57e-20 |
|
DNA topoisomerase I subunit omega; Validated
Pssm-ID: 236048 [Multi-domain] Cd Length: 859 Bit Score: 94.86 E-value: 6.57e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 1 MRLFIAEKPSLAKAIfeglggnpntekkNGYFehGSD-VVTWCYGHMLELydP---EDYDEKYSNWRFSDLpikSVYP-- 74
Cdd:PRK07561 2 KSLVIVESPAKAKTI-------------NKYL--GSDyVVKASVGHIRDL--PtsaSSVPAKEKGALWARM---GVDPdh 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 75 ---PQYKIKPESEAQTRIILSLIDKADNIVHAGDPDEEG-----CLLvdEILGyaKNTKSVYRLlV-------------- 132
Cdd:PRK07561 62 dfeALYEVLPGKEKVVSELKKAAKDADELYLATDPDREGeaiawHLL--EVLG--GDDVPVKRV-Vfneitknaiqeafe 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 133 --RDLNLApvqkaLTDLQpndkfrgmtlsaLARSLCDQGFGYNMT--------RGctlkgrekgydgvLNVGRVQSAVLG 202
Cdd:PRK07561 137 npRELDIN-----LVNAQ------------QARRFLDRLVGYMVSpllwkkiaRG-------------LSAGRVQSVAVR 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 203 LVNMRTLAnqnhTESF----YYDVFASLLM-NGHLIKAKYQTTDDDQIDeKKRLISEAQAAHIAGRVTGKDAVVTIATTK 277
Cdd:PRK07561 187 LIVERERE----IEAFvpeeYWDIHADLTTpRGDAFEARLTHLDGKKFA-PVDLLNEAQAEAAVAALEGARYSVASVEDK 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 278 PENTKPPLPLNLSTLQQLCAKRFGYSAKDTLDVMQGLYEThKLLTYPRSDNRYLSDEhyyqagdiatAIAATvpelASAI 357
Cdd:PRK07561 262 PTTRKPSAPFTTSTLQQEASRKLGFSVKKTMRIAQRLYEA-GYITYMRTDSTNLSQE----------AINAA----RGYI 326
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 358 ADM-------DK----SQKHKafNASkiEAHHAIIPT---TKSGAGIQLNEKERNVYNLVSVYFIGLFYPDAIRNKTKIh 423
Cdd:PRK07561 327 GDNygkkylpEKprqySSKAK--NAQ--EAHEAIRPSdvfRTPDQLKGLEGDAQRLYELIWKRFVASQMAPARYDSTTV- 401
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 424 fDIKGD--TFTATQSVLVQKGWEALgkdnddedetEDAGTDGFD------LSSLKFNDSGLCESADVDKKKTNPP-RYFT 494
Cdd:PRK07561 402 -TIAAGdaELRATGRVLRFDGFLKV----------YVEGRDDALddedrrLPALKVGDALTLEKLDPTQHFTKPPaRYSE 470
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 495 AStllaamtsaakfiddpaLRKALeakdegsEDRGsIGTEATRAGILEKLaantglisieKEKGYselVWK------TTK 568
Cdd:PRK07561 471 AS-----------------LVKEL-------EKLG-IGRPSTYASIISTI----------QDRGY---VRLenrrfyPEK 512
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 569 QG--------QEFcaalpPEITKPDISALWAEKQSQIKAGEL----TVEEFIKENDEYVQGLIDELERNGV---SISSNA 633
Cdd:PRK07561 513 MGrivtdrleEFF-----PRLVDYDFTARMEEELDDIANGEAdwkpVLDDFYKDFSQQLEKAEELREEGGMrpnQMVITD 587
|
730 740 750
....*....|....*....|....*....|....*.
gi 2785401644 634 TPCPVCNNGfLRKRKGQNGFFWGCSCY---PECKTT 666
Cdd:PRK07561 588 RDCPTCGRG-MGIRTGKTGVFLGCSGYalkERCKTT 622
|
|
| Toprim_Crpt |
pfam13342 |
C-terminal repeat of topoisomerase; |
711-772 |
9.91e-20 |
|
C-terminal repeat of topoisomerase;
Pssm-ID: 463851 [Multi-domain] Cd Length: 60 Bit Score: 83.30 E-value: 9.91e-20
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2785401644 711 GCEFKIWSEVSGKKLTQNQVETLIKKGKTGEIKGFTSnKTGKKFDAAIVLQDKatGKLGFQF 772
Cdd:pfam13342 1 GCGFSIGKTIAGKKLSEEQVKELLTKGKTGLIKGFKS-KKGKKFDAYLVLDDD--EKVEFDF 59
|
|
| PRK08780 |
PRK08780 |
DNA topoisomerase I; Provisional |
3-502 |
9.82e-19 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 181555 [Multi-domain] Cd Length: 780 Bit Score: 90.98 E-value: 9.82e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 3 LFIAEKPSLAKAIFEGLGGNpntekkngyFEhgsdvVTWCYGHMLELY------DPEDydekysnwrfsDLPIKsvyppq 76
Cdd:PRK08780 5 LVIVESPAKAKTINKYLGKD---------FT-----VLASYGHVRDLVpkegavDPEN-----------GFAMR------ 53
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 77 YKIKPESEAQTRIILSLIDKADNIVHAGDPDEEGCLL---VDEIL---GYAKNtKSVYRLLVRDLNLAPVQKALtdLQPN 150
Cdd:PRK08780 54 YDLIDKNEKHVEAIAKAAKSADDLYLATDPDREGEAIswhLAEILkerGLLKD-KPMQRVVFTEITPRAIKEAM--AKPR 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 151 DKFRGMTLSALARSLCDQGFGYNM--------TRGctlkgrekgydgvLNVGRVQSAVLGLVNMRtlanQNHTESF---- 218
Cdd:PRK08780 131 DIASDLVDAQQARRALDYLVGFNLspllwrkiQRG-------------LSAGRVQSPALRMIVER----EEEIEAFiare 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 219 YYDVFASLLMNGHLIKAK-----------YQTTDDDQIDEKKRLISEAQAahiaGRVTgkdavVTIATTKPENTKPPLPL 287
Cdd:PRK08780 194 YWSIEADCAHPSQPFNAKlikldgqkfeqFTITDGDTAEAARLRIQQAAQ----GTLH-----VTDVESKERKRNPAPPF 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 288 NLSTLQQLCAKRFGYSAKDTLDVMQGLYE--------THKLLTYPRSDNRYLSDEhyyQAGDIATAIAATVPelASAIAD 359
Cdd:PRK08780 265 TTSTLQQEASRKLGFTTRRTMQVAQKLYEgvdlgdegSVGLITYMRTDSVNLSQD---ALAEIRDVIARDYG--TASLPD 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 360 MDKSQKHKAFNASkiEAHHAIIPTTKSGAGIQ----LNEKERNVYNLVSVYFIGLFYPDAIRNKTKIHFDI-KGDTFTAT 434
Cdd:PRK08780 340 QPNTYKTKSKNAQ--EAHEAVRPTSALRTPAQvarfLSDDQRRLYELIWKRAVACQMIPATLNTVSVDLAAgSEHVFRAT 417
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2785401644 435 QSVLVQKGWEAL---GKDNDDEDEtedaGTDGFDLSSLKFNDSGLCESADVDKKKTNPPRYFTASTLLAAM 502
Cdd:PRK08780 418 GSTVVVPGFLAVyeeGKDDKSAED----EDEGRKLPPMKEGDNVPLERIRAEQHFTEPPPRYTEASLVKAL 484
|
|
| zf-C4_Topoisom |
pfam01396 |
Topoisomerase DNA binding C4 zinc finger; |
636-671 |
1.57e-06 |
|
Topoisomerase DNA binding C4 zinc finger;
Pssm-ID: 307520 [Multi-domain] Cd Length: 39 Bit Score: 45.33 E-value: 1.57e-06
10 20 30
....*....|....*....|....*....|....*.
gi 2785401644 636 CPVCNnGFLRKRKGQNGFFWGCSCYPECKTTFPDKD 671
Cdd:pfam01396 4 CPKCG-GDLVLKRGRFGKFVGCSNYPECRFTRPLKK 38
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
2-120 |
1.70e-05 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 43.88 E-value: 1.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 2 RLFIAEKPSLAKAIFEGLGGnpntekkngyfehGSDVVTWCYGHMLELydPEDYDEKYSNwrfsdlpiksvyppqykikp 81
Cdd:pfam01751 1 ELIIVEGPSDAIALEKALGG-------------GFQAVVAVLGHLLSL--EKGPKKKALK-------------------- 45
|
90 100 110
....*....|....*....|....*....|....*....
gi 2785401644 82 eseaqtrIILSLIDKADNIVHAGDPDEEGCLLVDEILGY 120
Cdd:pfam01751 46 -------ALKELALKAKEVILATDPDREGEAIALKLLEL 77
|
|
| TOPRIM_TopoIA_TopoI |
cd03363 |
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA ... |
1-127 |
5.78e-05 |
|
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173783 [Multi-domain] Cd Length: 123 Bit Score: 43.32 E-value: 5.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2785401644 1 MRLFIAEKPSLAKAIFEGLGgnpntekkNGYfehgsdVVTWCYGHMLELydPEDydekysnwRFSDLPIKSVYPPQYKIK 80
Cdd:cd03363 1 KKLVIVESPAKAKTIKKYLG--------KEY------EVLASVGHIRDL--PKK--------GLGVDGEDDGFEPKYVVI 56
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 2785401644 81 PESEAQTRIILSLIDKADNIVHAGDPDEEG---CLLVDEILGYAKNTKSV 127
Cdd:cd03363 57 PGKKKVVKELKKLAKKADEIYLATDPDREGeaiAWHLAEVLKLKKNVKRV 106
|
|
| |
