NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|119187747|ref|XP_001244480|]
View 

uncharacterized protein CIMG_03921 [Coccidioides immitis RS]

Protein Classification

GID4/VID24 family protein( domain architecture ID 10561119)

GID4/VID24 family protein similar to human glucose-induced degradation protein 4 homolog, also called vacuolar import and degradation protein 24 homolog, the substrate-recognition subunit of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Vac_ImportDeg pfam09783
Vacuolar import and degradation protein; Members of this family are involved in the negative ...
426-589 2.76e-49

Vacuolar import and degradation protein; Members of this family are involved in the negative regulation of gluconeogenesis. They are required for both proteosome-dependent and vacuolar catabolite degradation of fructose-1,6-bisphosphatase (FBPase), where they probably regulate FBPase targeting from the FBPase-containing vesicles to the vacuole.


:

Pssm-ID: 462897  Cd Length: 162  Bit Score: 168.48  E-value: 2.76e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187747  426 SKMQQWPVKVTIHDIDYSTMTLSGTMEAYNIPDKTATnqsahIITFLEGEIIDFHtHTLETKN--FNASPEVDSCYWREL 503
Cdd:pfam09783  14 SGKKKYQVKVEIKTVDLPNSHLCGYLTIQGLTDDHPE-----ITTFFEGEIIDGK-YGFLTRKpeWGADEETDLEHWSKF 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187747  504 EPFQSQTPDEIvkslvskkwlsetLAKGWILMRWKErCFVSPSH---SRQGLTISGFYYISIRREDGHIAGMYYDPGSSP 580
Cdd:pfam09783  88 PPFRPLFAKDL-------------LNFRYIFMRWKE-KFLVPDHrvkTINGASFEGFYYICFDQSTGSIEGYYYHPSSEK 153

                  ....*....
gi 119187747  581 YQELTLNPV 589
Cdd:pfam09783 154 FQQLELKPV 162
 
Name Accession Description Interval E-value
Vac_ImportDeg pfam09783
Vacuolar import and degradation protein; Members of this family are involved in the negative ...
426-589 2.76e-49

Vacuolar import and degradation protein; Members of this family are involved in the negative regulation of gluconeogenesis. They are required for both proteosome-dependent and vacuolar catabolite degradation of fructose-1,6-bisphosphatase (FBPase), where they probably regulate FBPase targeting from the FBPase-containing vesicles to the vacuole.


Pssm-ID: 462897  Cd Length: 162  Bit Score: 168.48  E-value: 2.76e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187747  426 SKMQQWPVKVTIHDIDYSTMTLSGTMEAYNIPDKTATnqsahIITFLEGEIIDFHtHTLETKN--FNASPEVDSCYWREL 503
Cdd:pfam09783  14 SGKKKYQVKVEIKTVDLPNSHLCGYLTIQGLTDDHPE-----ITTFFEGEIIDGK-YGFLTRKpeWGADEETDLEHWSKF 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187747  504 EPFQSQTPDEIvkslvskkwlsetLAKGWILMRWKErCFVSPSH---SRQGLTISGFYYISIRREDGHIAGMYYDPGSSP 580
Cdd:pfam09783  88 PPFRPLFAKDL-------------LNFRYIFMRWKE-KFLVPDHrvkTINGASFEGFYYICFDQSTGSIEGYYYHPSSEK 153

                  ....*....
gi 119187747  581 YQELTLNPV 589
Cdd:pfam09783 154 FQQLELKPV 162
VID24 COG5073
Vacuolar import and degradation protein [Intracellular trafficking and secretion];
368-601 1.06e-24

Vacuolar import and degradation protein [Intracellular trafficking and secretion];


Pssm-ID: 227405  Cd Length: 272  Bit Score: 103.80  E-value: 1.06e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187747 368 SSPSMLSHRVPGSNRLIDPVIVN---GNENNRITV-----YTSSGRRYWAHSTSDLSGGSTDEPEsskMQQWPVKVTIHD 439
Cdd:COG5073   35 SSPNARSCSLNIVFHKHKKVETYymiRHKNKRRLFssytrRSGFLRNGAQFGGVQISGYPPLTVE---VNIDTVDLPKKD 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187747 440 iDYSTMTLSGTMEAYNIpdktaTNQSAHIITFLEGEIIDFHTHTLETKN---FNASPEVDSCYWRELEPFQSQTPDEIVK 516
Cdd:COG5073  112 -DYSLPHLCGTLNIQNL-----TDPSSTLTTYFEGEIIGFNKLPFATEKwsmAPASEEIDVCHWKRFPPFRMDNGTFIER 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187747 517 SLVSKKWLsETLAKGWILMRWKERCFVSPS---HSRQGLTISGFYYISIRREDGHIAGMYYDPGSSP-YQELTLNPVLKE 592
Cdd:COG5073  186 IFNQKSKD-YKINQRYIYMKWKELFLLPDPlqlDTISGASIDGFYYCCLDQETGYIQGYYYHPKHAEkSQQLELVPEQPR 264

                 ....*....
gi 119187747 593 rmAFPAYSF 601
Cdd:COG5073  265 --KSPSYSF 271
 
Name Accession Description Interval E-value
Vac_ImportDeg pfam09783
Vacuolar import and degradation protein; Members of this family are involved in the negative ...
426-589 2.76e-49

Vacuolar import and degradation protein; Members of this family are involved in the negative regulation of gluconeogenesis. They are required for both proteosome-dependent and vacuolar catabolite degradation of fructose-1,6-bisphosphatase (FBPase), where they probably regulate FBPase targeting from the FBPase-containing vesicles to the vacuole.


Pssm-ID: 462897  Cd Length: 162  Bit Score: 168.48  E-value: 2.76e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187747  426 SKMQQWPVKVTIHDIDYSTMTLSGTMEAYNIPDKTATnqsahIITFLEGEIIDFHtHTLETKN--FNASPEVDSCYWREL 503
Cdd:pfam09783  14 SGKKKYQVKVEIKTVDLPNSHLCGYLTIQGLTDDHPE-----ITTFFEGEIIDGK-YGFLTRKpeWGADEETDLEHWSKF 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187747  504 EPFQSQTPDEIvkslvskkwlsetLAKGWILMRWKErCFVSPSH---SRQGLTISGFYYISIRREDGHIAGMYYDPGSSP 580
Cdd:pfam09783  88 PPFRPLFAKDL-------------LNFRYIFMRWKE-KFLVPDHrvkTINGASFEGFYYICFDQSTGSIEGYYYHPSSEK 153

                  ....*....
gi 119187747  581 YQELTLNPV 589
Cdd:pfam09783 154 FQQLELKPV 162
VID24 COG5073
Vacuolar import and degradation protein [Intracellular trafficking and secretion];
368-601 1.06e-24

Vacuolar import and degradation protein [Intracellular trafficking and secretion];


Pssm-ID: 227405  Cd Length: 272  Bit Score: 103.80  E-value: 1.06e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187747 368 SSPSMLSHRVPGSNRLIDPVIVN---GNENNRITV-----YTSSGRRYWAHSTSDLSGGSTDEPEsskMQQWPVKVTIHD 439
Cdd:COG5073   35 SSPNARSCSLNIVFHKHKKVETYymiRHKNKRRLFssytrRSGFLRNGAQFGGVQISGYPPLTVE---VNIDTVDLPKKD 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187747 440 iDYSTMTLSGTMEAYNIpdktaTNQSAHIITFLEGEIIDFHTHTLETKN---FNASPEVDSCYWRELEPFQSQTPDEIVK 516
Cdd:COG5073  112 -DYSLPHLCGTLNIQNL-----TDPSSTLTTYFEGEIIGFNKLPFATEKwsmAPASEEIDVCHWKRFPPFRMDNGTFIER 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187747 517 SLVSKKWLsETLAKGWILMRWKERCFVSPS---HSRQGLTISGFYYISIRREDGHIAGMYYDPGSSP-YQELTLNPVLKE 592
Cdd:COG5073  186 IFNQKSKD-YKINQRYIYMKWKELFLLPDPlqlDTISGASIDGFYYCCLDQETGYIQGYYYHPKHAEkSQQLELVPEQPR 264

                 ....*....
gi 119187747 593 rmAFPAYSF 601
Cdd:COG5073  265 --KSPSYSF 271
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH