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Conserved domains on  [gi|119187751|ref|XP_001244482|]
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ankyrin repeat protein [Coccidioides immitis RS]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
321-432 2.55e-27

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 113.51  E-value: 2.55e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  321 QRDQNGRTRLARACAAQEVEAAKA--RYAAHPeelDVPDNAGNTPLQIAALEGSADIVKFLLEAGCDINTKNIDKDTPLI 398
Cdd:COG0666   115 ARDKDGETPLHLAAYNGNLEIVKLllEAGADV---NAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLH 191

                          90       100       110
                  ....*....|....*....|....*....|....
gi 119187751  399 DAVENGHLDVVKLLLNAGANPRVGNAEGDEPYDL 432
Cdd:COG0666   192 LAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 696-1012 2.41e-06

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 52.00  E-value: 2.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  696 ESRNQHHGSSKINRTRKDGGKDESLGQASTKshrKTPhddanseyhttsdhdSTRSRHTKQKLPSDSKKytdsgtaanyG 775
Cdd:PTZ00449  528 EGEEGEHEDSKESDEPKEGGKPGETKEGEVG---KKP---------------GPAKEHKPSKIPTLSKK----------P 579

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  776 EEPikrrrliagrppdrrrgsfmsTDSHSPRDEASKERVEkfshetrriKEVSPSKRTRGSvSPEPHQSRGRPGESSEDS 855
Cdd:PTZ00449  580 EFP---------------------KDPKHPKDPEEPKKPK---------RPRSAQRPTRPK-SPKLPELLDIPKSPKRPE 628

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  856 DPQKKKRKVeiecSPTRPSK----ESMKKTLVERPP-SPKPISQPK-------TTSSASTGSEKTEIGHTMHENTELKAT 923
Cdd:PTZ00449  629 SPKSPKRPP----PPQRPSSperpEGPKIIKSPKPPkSPKPPFDPKfkekfydDYLDAAAKSKETKTTVVLDESFESILK 704

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  924 SKDVEVPVSAQKLQYQTEPKLTTDaaiaEVSEHDTKenGQPDEhPEAKDSEQKGTP-EDSERIHPAMAAMSVKDEISEvk 1002
Cdd:PTZ00449  705 ETLPETPGTPFTTPRPLPPKLPRD----EEFPFEPI--GDPDA-EQPDDIEFFTPPeEERTFFHETPADTPLPDILAE-- 775

                         330
                  ....*....|
gi 119187751 1003 EVKEDEATKQ 1012
Cdd:PTZ00449  776 EFKEEDIHAE 785
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
512-627 7.02e-03

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 39.94  E-value: 7.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  512 ATRNDLLWTRPTPENLRDFAAKGDMAGVANILNVLQKADTESLIAAAKGSHDEVLGILLGMGNPDPNPepiksgnhKPGY 591
Cdd:COG0666    16 LLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK--------DDGG 87

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 119187751  592 NTPILAAIGRGNNSVIKLLLDQrGFDPTRLDHRGRT 627
Cdd:COG0666    88 NTLLHAAARNGDLEIVKLLLEA-GADVNARDKDGET 122
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
321-432 2.55e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 113.51  E-value: 2.55e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  321 QRDQNGRTRLARACAAQEVEAAKA--RYAAHPeelDVPDNAGNTPLQIAALEGSADIVKFLLEAGCDINTKNIDKDTPLI 398
Cdd:COG0666   115 ARDKDGETPLHLAAYNGNLEIVKLllEAGADV---NAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLH 191

                          90       100       110
                  ....*....|....*....|....*....|....
gi 119187751  399 DAVENGHLDVVKLLLNAGANPRVGNAEGDEPYDL 432
Cdd:COG0666   192 LAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225
Ank_2 pfam12796
Ankyrin repeats (3 copies);
330-421 3.52e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 74.77  E-value: 3.52e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751   330 LARACAAQEVEAAKaRYAAHPEELDVPDNAGNTPLQIAALEGSADIVKFLLEaGCDINTKNiDKDTPLIDAVENGHLDVV 409
Cdd:pfam12796    1 LHLAAKNGNLELVK-LLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIV 77

                           90
                   ....*....|..
gi 119187751   410 KLLLNAGANPRV 421
Cdd:pfam12796   78 KLLLEKGADINV 89
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 353-418 2.35e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 73.55  E-value: 2.35e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119187751  353 LDVPDNAGNTPLQIAALEGSADIVKFLLEAGCDINTKNIDKDTPLIDAVENGHLDVVKLLLNAGAN 418
Cdd:PHA03100  185 INIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPS 250
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 696-1012 2.41e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 52.00  E-value: 2.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  696 ESRNQHHGSSKINRTRKDGGKDESLGQASTKshrKTPhddanseyhttsdhdSTRSRHTKQKLPSDSKKytdsgtaanyG 775
Cdd:PTZ00449  528 EGEEGEHEDSKESDEPKEGGKPGETKEGEVG---KKP---------------GPAKEHKPSKIPTLSKK----------P 579

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  776 EEPikrrrliagrppdrrrgsfmsTDSHSPRDEASKERVEkfshetrriKEVSPSKRTRGSvSPEPHQSRGRPGESSEDS 855
Cdd:PTZ00449  580 EFP---------------------KDPKHPKDPEEPKKPK---------RPRSAQRPTRPK-SPKLPELLDIPKSPKRPE 628

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  856 DPQKKKRKVeiecSPTRPSK----ESMKKTLVERPP-SPKPISQPK-------TTSSASTGSEKTEIGHTMHENTELKAT 923
Cdd:PTZ00449  629 SPKSPKRPP----PPQRPSSperpEGPKIIKSPKPPkSPKPPFDPKfkekfydDYLDAAAKSKETKTTVVLDESFESILK 704

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  924 SKDVEVPVSAQKLQYQTEPKLTTDaaiaEVSEHDTKenGQPDEhPEAKDSEQKGTP-EDSERIHPAMAAMSVKDEISEvk 1002
Cdd:PTZ00449  705 ETLPETPGTPFTTPRPLPPKLPRD----EEFPFEPI--GDPDA-EQPDDIEFFTPPeEERTFFHETPADTPLPDILAE-- 775

                         330
                  ....*....|
gi 119187751 1003 EVKEDEATKQ 1012
Cdd:PTZ00449  776 EFKEEDIHAE 785
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 321-420 8.23e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 50.01  E-value: 8.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  321 QRDQNGRTRLARACAAQEVEAAKARYAAHPEELDVPDN----AGNTPLQIAALEGSADIVKFLLEAGCDINT-------- 388
Cdd:cd22192    46 QRGALGETALHVAALYDNLEAAVVLMEAAPELVNEPMTsdlyQGETALHIAVVNQNLNLVRELIARGADVVSpratgtff 125

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 119187751  389 -KNIDK-----DTPLIDAVENGHLDVVKLLLNAGANPR 420
Cdd:cd22192   126 rPGPKNliyygEHPLSFAACVGNEEIVRLLIEHGADIR 163
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 392-419 1.64e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.57  E-value: 1.64e-05
                            10        20
                    ....*....|....*....|....*...
gi 119187751    392 DKDTPLIDAVENGHLDVVKLLLNAGANP 419
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
512-627 7.02e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 39.94  E-value: 7.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  512 ATRNDLLWTRPTPENLRDFAAKGDMAGVANILNVLQKADTESLIAAAKGSHDEVLGILLGMGNPDPNPepiksgnhKPGY 591
Cdd:COG0666    16 LLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK--------DDGG 87

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 119187751  592 NTPILAAIGRGNNSVIKLLLDQrGFDPTRLDHRGRT 627
Cdd:COG0666    88 NTLLHAAARNGDLEIVKLLLEA-GADVNARDKDGET 122
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
321-432 2.55e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 113.51  E-value: 2.55e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  321 QRDQNGRTRLARACAAQEVEAAKA--RYAAHPeelDVPDNAGNTPLQIAALEGSADIVKFLLEAGCDINTKNIDKDTPLI 398
Cdd:COG0666   115 ARDKDGETPLHLAAYNGNLEIVKLllEAGADV---NAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLH 191

                          90       100       110
                  ....*....|....*....|....*....|....
gi 119187751  399 DAVENGHLDVVKLLLNAGANPRVGNAEGDEPYDL 432
Cdd:COG0666   192 LAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
321-429 1.59e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 108.12  E-value: 1.59e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  321 QRDQNGRTRLARACAAQEVEAAKArYAAHPEELDVPDNAGNTPLQIAALEGSADIVKFLLEAGCDINTKNIDKDTPLIDA 400
Cdd:COG0666    82 AKDDGGNTLLHAAARNGDLEIVKL-LLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160

                          90       100
                  ....*....|....*....|....*....
gi 119187751  401 VENGHLDVVKLLLNAGANPRVGNAEGDEP 429
Cdd:COG0666   161 AANGNLEIVKLLLEAGADVNARDNDGETP 189
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
321-459 2.24e-21

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 96.18  E-value: 2.24e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  321 QRDQNGRTRLARACAAQEVEAAKArYAAHPEELDVPDNAGNTPLQIAALEGSADIVKFLLEAGCDINTKNIDKDTPLIDA 400
Cdd:COG0666   148 AQDNDGNTPLHLAAANGNLEIVKL-LLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLA 226

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 119187751  401 VENGHLDVVKLLLNAGANPRVGNAEGDEPYDLVPSDSENYDKLRTVLAEAKVKGIHRRK 459
Cdd:COG0666   227 AENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDL 285
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
323-429 1.03e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 91.17  E-value: 1.03e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  323 DQNGRTRLARACAAQEVEAAKARYAAHPEELDVPDNAGNTPLQIAALEGSADIVKFLLEAGCDINTKNIDKDTPLIDAVE 402
Cdd:COG0666    50 ADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAY 129

                          90       100
                  ....*....|....*....|....*..
gi 119187751  403 NGHLDVVKLLLNAGANPRVGNAEGDEP 429
Cdd:COG0666   130 NGNLEIVKLLLEAGADVNAQDNDGNTP 156
Ank_2 pfam12796
Ankyrin repeats (3 copies);
330-421 3.52e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 74.77  E-value: 3.52e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751   330 LARACAAQEVEAAKaRYAAHPEELDVPDNAGNTPLQIAALEGSADIVKFLLEaGCDINTKNiDKDTPLIDAVENGHLDVV 409
Cdd:pfam12796    1 LHLAAKNGNLELVK-LLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIV 77

                           90
                   ....*....|..
gi 119187751   410 KLLLNAGANPRV 421
Cdd:pfam12796   78 KLLLEKGADINV 89
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 353-418 2.35e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 73.55  E-value: 2.35e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119187751  353 LDVPDNAGNTPLQIAALEGSADIVKFLLEAGCDINTKNIDKDTPLIDAVENGHLDVVKLLLNAGAN 418
Cdd:PHA03100  185 INIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPS 250
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
328-653 5.40e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.06  E-value: 5.40e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  328 TRLARACAAQEVEAAKARYAAHPEELDVPDNAGNTPLQIAALEGSADIVKFLLEAGCDINTKNIDKDTPLIDAVENGHLD 407
Cdd:COG0666    22 ALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLE 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  408 VVKLLLNAGANPRVGNAEGDEPydLVPSDSENYDKLRTVLAEAkvkgihrrksvdmgsrgsayptkeassrgasaasprd 487
Cdd:COG0666   102 IVKLLLEAGADVNARDKDGETP--LHLAAYNGNLEIVKLLLEA------------------------------------- 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  488 sppvfGArnsppaglsrrrtvrseatrnDLlwtrptpeNLRDfaAKGDMAgvanilnvlqkadtesLIAAAKGSHDEVLG 567
Cdd:COG0666   143 -----GA---------------------DV--------NAQD--NDGNTP----------------LHLAAANGNLEIVK 170

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  568 ILLGMGnPDPNpepIKSGNhkpgYNTPILAAIGRGNNSVIKLLLDqRGFDPTRLDHRGRTYYQISEERKgeNWEAERKLL 647
Cdd:COG0666   171 LLLEAG-ADVN---ARDND----GETPLHLAAENGHLEIVKLLLE-AGADVNAKDNDGKTALDLAAENG--NLEIVKLLL 239


                  ....*.
gi 119187751  648 RDAYDN 653
Cdd:COG0666   240 EAGADL 245
Ank_4 pfam13637
Ankyrin repeats (many copies);
360-413 2.73e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 56.90  E-value: 2.73e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 119187751   360 GNTPLQIAALEGSADIVKFLLEAGCDINTKNIDKDTPLIDAVENGHLDVVKLLL 413
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
322-428 9.50e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.12  E-value: 9.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  322 RDQNGRTRLARACAAQEVEAAKA--RYAAHPeelDVPDNAGNTPLQIAALEGSADIVKFLLEAGCDINTKNIDKDTPLID 399
Cdd:COG0666   182 RDNDGETPLHLAAENGHLEIVKLllEAGADV---NAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLL 258

                          90       100
                  ....*....|....*....|....*....
gi 119187751  400 AVENGHLDVVKLLLNAGANPRVGNAEGDE 428
Cdd:COG0666   259 AAAAGAALIVKLLLLALLLLAAALLDLLT 287
Ank_2 pfam12796
Ankyrin repeats (3 copies);
319-390 2.50e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.51  E-value: 2.50e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119187751   319 KRQRDQNGRTRLARACAAQEVEAAKA--RYAAhpeeLDVPDNaGNTPLQIAALEGSADIVKFLLEAGCDINTKN 390
Cdd:pfam12796   23 ANLQDKNGRTALHLAAKNGHLEIVKLllEHAD----VNLKDN-GRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 374-429 1.65e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 58.52  E-value: 1.65e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 119187751  374 DIVKFLLEAGCDINTKNIDKDTPLIDAVENGHLDVVKLLLNAGANPRVGNAEGDEP 429
Cdd:PHA03100  173 NRVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTP 228
PHA03095 PHA03095
ankyrin-like protein; Provisional
 357-429 4.32e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 57.34  E-value: 4.32e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119187751  357 DNAGNTPLQI---AALEGSADIVKFLLEAGCDINTKNIDKDTPLIDAVENGH-LDVVKLLLNAGANPRVGNAEGDEP 429
Cdd:PHA03095   44 GEYGKTPLHLylhYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTP 120
Ank_5 pfam13857
Ankyrin repeats (many copies);
379-433 6.01e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 50.42  E-value: 6.01e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 119187751   379 LLEAG-CDINTKNIDKDTPLIDAVENGHLDVVKLLLNAGANPRVGNAEGDEPYDLV 433
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_5 pfam13857
Ankyrin repeats (many copies);
347-397 1.06e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 49.65  E-value: 1.06e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 119187751   347 AAHPEELDVPDNAGNTPLQIAALEGSADIVKFLLEAGCDINTKNIDKDTPL 397
Cdd:pfam13857    3 EHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 322-429 1.20e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 55.74  E-value: 1.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  322 RDQNGRTRLARACAAQEVEAAKA--RYAAhpeELDVPDNAGNTPLQIAALEGSADIVKFLLEAGCDINTKNIDKDTPLID 399
Cdd:PHA02874  120 KDAELKTFLHYAIKKGDLESIKMlfEYGA---DVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHN 196

                          90       100       110
                  ....*....|....*....|....*....|
gi 119187751  400 AVENGHLDVVKLLLNAGANPRVGNAEGDEP 429
Cdd:PHA02874  197 AAEYGDYACIKLLIDHGNHIMNKCKNGFTP 226
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 332-432 2.40e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 55.29  E-value: 2.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  332 RACAAQEVEAAKARYAAHPEELDVPDNAGNTPLQIAALEGSADIV--KFLLEAGCDINTKNIDKDTPLIDAVENGHLDVV 409
Cdd:PTZ00322   52 EALEATENKDATPDHNLTTEEVIDPVVAHMLTVELCQLAASGDAVgaRILLTGGADPNCRDYDGRTPLHIACANGHVQVV 131

                          90       100
                  ....*....|....*....|...
gi 119187751  410 KLLLNAGANPRVGNAEGDEPYDL 432
Cdd:PTZ00322  132 RVLLEFGADPTLLDKDGKTPLEL 154
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 354-418 2.78e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 54.67  E-value: 2.78e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119187751  354 DVPDNAGNTPLQIAALE--GSADIVKFLLEAGCDINTKNIDKDTPLIDAVENGH--LDVVKLLLNAGAN 418
Cdd:PHA03100  100 NAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVD 168
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 354-422 7.59e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 53.72  E-value: 7.59e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119187751  354 DVPDNAGNTPLQIAALEGSADIVKFLLEAGCDINTKNIDKDTPLIDAVENGHLDVVKLL--LNAGANPRVG 422
Cdd:PLN03192  552 DIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILyhFASISDPHAA 622
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 696-1012 2.41e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 52.00  E-value: 2.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  696 ESRNQHHGSSKINRTRKDGGKDESLGQASTKshrKTPhddanseyhttsdhdSTRSRHTKQKLPSDSKKytdsgtaanyG 775
Cdd:PTZ00449  528 EGEEGEHEDSKESDEPKEGGKPGETKEGEVG---KKP---------------GPAKEHKPSKIPTLSKK----------P 579

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  776 EEPikrrrliagrppdrrrgsfmsTDSHSPRDEASKERVEkfshetrriKEVSPSKRTRGSvSPEPHQSRGRPGESSEDS 855
Cdd:PTZ00449  580 EFP---------------------KDPKHPKDPEEPKKPK---------RPRSAQRPTRPK-SPKLPELLDIPKSPKRPE 628

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  856 DPQKKKRKVeiecSPTRPSK----ESMKKTLVERPP-SPKPISQPK-------TTSSASTGSEKTEIGHTMHENTELKAT 923
Cdd:PTZ00449  629 SPKSPKRPP----PPQRPSSperpEGPKIIKSPKPPkSPKPPFDPKfkekfydDYLDAAAKSKETKTTVVLDESFESILK 704

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  924 SKDVEVPVSAQKLQYQTEPKLTTDaaiaEVSEHDTKenGQPDEhPEAKDSEQKGTP-EDSERIHPAMAAMSVKDEISEvk 1002
Cdd:PTZ00449  705 ETLPETPGTPFTTPRPLPPKLPRD----EEFPFEPI--GDPDA-EQPDDIEFFTPPeEERTFFHETPADTPLPDILAE-- 775

                         330
                  ....*....|
gi 119187751 1003 EVKEDEATKQ 1012
Cdd:PTZ00449  776 EFKEEDIHAE 785
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 348-447 2.93e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 51.42  E-value: 2.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  348 AHPEELDVPD-NAGNTPLQIAALEGSADIVKFLLEAGCDINTKNIDKDTPLIDAVENGHLDVVKLLLNAGANPRVGNAEG 426
Cdd:PHA02878  155 SYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCG 234

                          90       100
                  ....*....|....*....|.
gi 119187751  427 DEPYDLVPSDSENYDKLRTVL 447
Cdd:PHA02878  235 NTPLHISVGYCKDYDILKLLL 255
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 324-427 2.96e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 51.15  E-value: 2.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  324 QNGRTRLARACAAQEVEAAKA--RYAAHPeelDVPDNAGNTPLQIAALEGSADIVKFLLEAGCDINTKNIDKDTPLIDAV 401
Cdd:PHA02875  100 KDGMTPLHLATILKKLDIMKLliARGADP---DIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAM 176

                          90       100
                  ....*....|....*....|....*.
gi 119187751  402 ENGHLDVVKLLLNAGANPRVGNAEGD 427
Cdd:PHA02875  177 AKGDIAICKMLLDSGANIDYFGKNGC 202
PHA03095 PHA03095
ankyrin-like protein; Provisional
 353-448 3.91e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.79  E-value: 3.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  353 LDVPDNAGNTPLQIAALEGS-ADIVKFLLEAGCDINTKNIDKDTPL--IDAVENGHLDVVKLLLNAGANPRVGNAEGDEP 429
Cdd:PHA03095   76 VNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLhvYLSGFNINPKVIRLLLRKGADVNALDLYGMTP 155

                          90       100
                  ....*....|....*....|
gi 119187751  430 YD-LVPSDSENYDKLRTVLA 448
Cdd:PHA03095  156 LAvLLKSRNANVELLRLLID 175
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 360-390 3.94e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 44.59  E-value: 3.94e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 119187751   360 GNTPLQIAALE-GSADIVKFLLEAGCDINTKN 390
Cdd:pfam00023    2 GNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 321-420 8.23e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 50.01  E-value: 8.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  321 QRDQNGRTRLARACAAQEVEAAKARYAAHPEELDVPDN----AGNTPLQIAALEGSADIVKFLLEAGCDINT-------- 388
Cdd:cd22192    46 QRGALGETALHVAALYDNLEAAVVLMEAAPELVNEPMTsdlyQGETALHIAVVNQNLNLVRELIARGADVVSpratgtff 125

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 119187751  389 -KNIDK-----DTPLIDAVENGHLDVVKLLLNAGANPR 420
Cdd:cd22192   126 rPGPKNliyygEHPLSFAACVGNEEIVRLLIEHGADIR 163
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 357-429 1.15e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.90  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  357 DNAGNTPLQIAALEGSADIVKFLLEAGCDINTKNIDKDTPLIDAVENGHLDVVKLLL-------NAGANPRVGNAEGDEP 429
Cdd:PTZ00322  112 DYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSrhsqchfELGANAKPDSFTGKPP 191
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 392-419 1.64e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.57  E-value: 1.64e-05
                            10        20
                    ....*....|....*....|....*...
gi 119187751    392 DKDTPLIDAVENGHLDVVKLLLNAGANP 419
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 360-388 2.00e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 42.63  E-value: 2.00e-05
                           10        20
                   ....*....|....*....|....*....
gi 119187751   360 GNTPLQIAALEGSADIVKFLLEAGCDINT 388
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 360-387 2.02e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.57  E-value: 2.02e-05
                            10        20
                    ....*....|....*....|....*...
gi 119187751    360 GNTPLQIAALEGSADIVKFLLEAGCDIN 387
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADIN 29
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 322-532 2.10e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 49.10  E-value: 2.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  322 RDQNGRTRLARACAAQEVEAAKARYaaHPEELDVPDNAGNTpLQIAALEGSADIVKFLLEAGCDINTKNIDKDTPLIDAV 401
Cdd:PLN03192  587 RDANGNTALWNAISAKHHKIFRILY--HFASISDPHAAGDL-LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAM 663

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  402 ENGHLDVVKLLLNAGANprVGNAEGDEpyDLVPSDSENYDKLRTVLAEAKVKGIHRRKSVDMGSRGSAYPTKEASSRGAS 481
Cdd:PLN03192  664 AEDHVDMVRLLIMNGAD--VDKANTDD--DFSPTELRELLQKRELGHSITIVDSVPADEPDLGRDGGSRPGRLQGTSSDN 739

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 119187751  482 AASPRDSppVFgaRNSPpagLSRRRTVRSEATRNDLLwtrptPENLRDFAA 532
Cdd:PLN03192  740 QCRPRVS--IY--KGHP---LLRNERCCNEAGKLINL-----PPSLEELKA 778
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 349-418 2.58e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 48.06  E-value: 2.58e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 119187751  349 HPEELDVPDNAGNTPLQIAALEGSADIVKFLLEAGCDIN--TKNIDKdTPLIDAVENGHLDVVKLLLNAGAN 418
Cdd:PHA02875  157 HKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDyfGKNGCV-AALCYAIENNKIDIVRLFIKRGAD 227
Ank_4 pfam13637
Ankyrin repeats (many copies);
326-380 4.98e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.88  E-value: 4.98e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 119187751   326 GRTRLARACAAQEVEAAKaRYAAHPEELDVPDNAGNTPLQIAALEGSADIVKFLL 380
Cdd:pfam13637    1 ELTALHAAAASGHLELLR-LLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 373-429 8.60e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 46.58  E-value: 8.60e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 119187751  373 ADIVKFLLEAGCDINTKNIDKDTPL-----IDAVENGHLDVVKLLLNAGANPRVGNAEGDEP 429
Cdd:PHA03100   48 IDVVKILLDNGADINSSTKNNSTPLhylsnIKYNLTDVKEIVKLLLEYGANVNAPDNNGITP 109
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 354-433 1.32e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 46.03  E-value: 1.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  354 DVPDNAGNTPLQIAALE-GSADIVKFLLEAGCDINTKN-IDKDTPLIDAVENGhlDVVKLLLNAGANPRVGNAEGDEPYD 431
Cdd:PHA02878  228 DARDKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKSyILGLTALHSSIKSE--RKLKLLLEYGADINSLNSYKLTPLS 305


                  ..
gi 119187751  432 LV 433
Cdd:PHA02878  306 SA 307
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 354-429 1.39e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 45.75  E-value: 1.39e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119187751  354 DVPDNAGNTPLQIAALEGSADIVKFLLEAGCDINTKNIDKDTPLIDAVENGHLDVVKLLLNAGANPRVGNAEGDEP 429
Cdd:PHA02875   96 DVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTP 171
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 374-447 2.96e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.95  E-value: 2.96e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119187751  374 DIVKFLLEAGCDINTKNIDKDTPLIDAVENGHLDVVKLLLNAGANPRVGNAEGDEPYDlVPSDSENYDKLRTVL 447
Cdd:PHA02874  105 DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIH-IAIKHNFFDIIKLLL 177
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 352-429 3.01e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.95  E-value: 3.01e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119187751  352 ELDVPDNAGNTPLQIAALEGSADIVKFLLEAGCDINTKNIDKDTPLIDAVENGHLDVVKLLLNAGANPRVGNAEGDEP 429
Cdd:PHA02874  116 DVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESP 193
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 392-423 5.08e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.42  E-value: 5.08e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 119187751   392 DKDTPLIDAVE-NGHLDVVKLLLNAGANPRVGN 423
Cdd:pfam00023    1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 362-421 8.69e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.41  E-value: 8.69e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  362 TPLQIAALEGSADIVKFLLEAGCDINTKNIDKDTPLIDAVENGHLDVVKLLLNAGANPRV 421
Cdd:PHA02874   37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSI 96
Ank_2 pfam12796
Ankyrin repeats (3 copies);
397-429 9.15e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 39.71  E-value: 9.15e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 119187751   397 LIDAVENGHLDVVKLLLNAGANPRVGNAEGDEP 429
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTA 33
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 373-429 1.48e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 42.56  E-value: 1.48e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 119187751  373 ADIVKFLLEAGCDINTKNIDKD-TPLIDAVENGHLDVVKLLLNAGANPRVGNAEGDEP 429
Cdd:PHA02878  147 AEITKLLLSYGADINMKDRHKGnTALHYATENKDQRLTELLLSYGANVNIPDKTNNSP 204
PTZ00121 PTZ00121
MAEBL; Provisional
 634-1075 2.03e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.82  E-value: 2.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  634 ERKGENWEAERKLLRDAYDNYLSSSKAAKSDVRTSKKSRDVRNSLEDSVSPASSHRRSA-----RSPESRNQHHGSSKIN 708
Cdd:PTZ00121 1342 KKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAeedkkKADELKKAAAAKKKAD 1421

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  709 RTRKDGGKDESLGQASTKSHRKTPHDDANSEYHTTSDHDSTRSRHTKQKLPSDSKKYTDSGTAAnygeEPIKRRRLIAGR 788
Cdd:PTZ00121 1422 EAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKA----DEAKKKAEEAKK 1497

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  789 PPDRRRgsfMSTDSHSPRDEASKERVEKFSHETRRIKEvspsKRTRGSVSPEPHQSRGRPGESSEDSDPQKKKRKVEiec 868
Cdd:PTZ00121 1498 KADEAK---KAAEAKKKADEAKKAEEAKKADEAKKAEE----AKKADEAKKAEEKKKADELKKAEELKKAEEKKKAE--- 1567

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  869 sptRPSKESMKKTLVERppspkpisqpktTSSASTGSEKTEIGHTMHENTElkatskdvEVPVSAQKLQYQTEPKLTTDA 948
Cdd:PTZ00121 1568 ---EAKKAEEDKNMALR------------KAEEAKKAEEARIEEVMKLYEE--------EKKMKAEEAKKAEEAKIKAEE 1624

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  949 AIAEVSEHDTKENGQPDEHPEAKDSEQKGTPEDSERIHPAMAAMSVKDEISEVKEVKEDEATKQAAKLALEQAEQERRRE 1028
Cdd:PTZ00121 1625 LKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKA 1704

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 119187751 1029 ---EEERKRKEAEERRIRQAEEEHQRRIEEEHRQArlRKEQEKQEQRRRD 1075
Cdd:PTZ00121 1705 eelKKKEAEEKKKAEELKKAEEENKIKAEEAKKEA--EEDKKKAEEAKKD 1752
PTZ00121 PTZ00121
MAEBL; Provisional
 614-1070 2.37e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 2.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  614 RGFDPTRLDHRgrtYYQISEERKGENWEAERKLLRDAYDNYLSSSKAAKSDVRTSKKSRDVRNSLE----DSVSPASSHR 689
Cdd:PTZ00121 1070 EGLKPSYKDFD---FDAKEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEarkaEDARKAEEAR 1146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  690 RS--ARSPESRNQHHGSSKINRTRK--DGGKDESLGQAST--------KSHRKTPHDDANSEYHTTSDHDSTRSRHTK-- 755
Cdd:PTZ00121 1147 KAedAKRVEIARKAEDARKAEEARKaeDAKKAEAARKAEEvrkaeelrKAEDARKAEAARKAEEERKAEEARKAEDAKka 1226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  756 ---QKLPSDSKKYTDSGTAANYGEEPIKRRRLIAGRPPDRRRGSFMSTDSHSPRDEASKERVEKFSHETRRIKEVSPSK- 831
Cdd:PTZ00121 1227 eavKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADe 1306

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  832 -RTRGSVSPEPHQSRGRPGESSEDSDPQKKKRKVEIECSPTRPSKESMKKTLVERPPSPKPISQPKTTSSASTGSEKTEI 910
Cdd:PTZ00121 1307 aKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKK 1386

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  911 GHTMHENTELKatSKDVEVPVSAQKLQYQTEPKLTTDAAIAEVSEHDTKENGQPDEHPEAKDSEQKGTPEDSERIHPAMA 990
Cdd:PTZ00121 1387 AEEKKKADEAK--KKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKK 1464

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  991 AMSVKDEISEVKEVKE-----DEATKQAAKLALEQAEQERRREEEERKRKEAEERRIRQAEEehQRRIEEEHRQARLRKE 1065
Cdd:PTZ00121 1465 KAEEAKKADEAKKKAEeakkaDEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADE--AKKAEEAKKADEAKKA 1542


                  ....*
gi 119187751 1066 QEKQE 1070
Cdd:PTZ00121 1543 EEKKK 1547
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 357-447 2.77e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 41.97  E-value: 2.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  357 DNAGNTPLQIAALEGS-ADIVKFLLEAGCDINTKNIDKDTPLIDAVENGH-LDVVKLLLNAGANPRVGNAEGDEPYDLVP 434
Cdd:PHA02876  270 DDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQAS 349

                          90
                  ....*....|...
gi 119187751  435 SDSENYDKLRTVL 447
Cdd:PHA02876  350 TLDRNKDIVITLL 362
PHA02798 PHA02798
ankyrin-like protein; Provisional
 349-413 2.79e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 41.74  E-value: 2.79e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  349 HPEELDVPDNAGNTPL-----QIAALEGSADIVKFLLEAGCDINTKNIDKDTPLIDAVENGHLDVVKLLL 413
Cdd:PHA02798   60 LGANVNGLDNEYSTPLctilsNIKDYKHMLDIVKILIENGADINKKNSDGETPLYCLLSNGYINNLEILL 129
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 360-426 2.96e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 41.79  E-value: 2.96e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119187751  360 GNTPLQIAAleGSADIVKFLLEAGCDINTKNIDKDTPLIDAV------ENGHLDVVKLLLNAGANPRVGNAEG 426
Cdd:PHA02878  269 GLTALHSSI--KSERKLKLLLEYGADINSLNSYKLTPLSSAVkqylciNIGRILISNICLLKRIKPDIKNSEG 339
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
512-627 7.02e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 39.94  E-value: 7.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  512 ATRNDLLWTRPTPENLRDFAAKGDMAGVANILNVLQKADTESLIAAAKGSHDEVLGILLGMGNPDPNPepiksgnhKPGY 591
Cdd:COG0666    16 LLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK--------DDGG 87

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 119187751  592 NTPILAAIGRGNNSVIKLLLDQrGFDPTRLDHRGRT 627
Cdd:COG0666    88 NTLLHAAARNGDLEIVKLLLEA-GADVNARDKDGET 122
PHA02798 PHA02798
ankyrin-like protein; Provisional
 372-429 9.76e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 40.20  E-value: 9.76e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119187751  372 SADIVKFLLEAGCDINTKNIDKDTPLIDAVEN-----GHLDVVKLLLNAGANPRVGNAEGDEP 429
Cdd:PHA02798   50 STDIVKLFINLGANVNGLDNEYSTPLCTILSNikdykHMLDIVKILIENGADINKKNSDGETP 112
PHA03095 PHA03095
ankyrin-like protein; Provisional
 357-448 9.82e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 40.01  E-value: 9.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119187751  357 DNAGNTPLQIAALEGS--ADIVKFLLEAGCDINTKNIDKDTPLIDAVENGHLDVVKLLLNAGANPRVGNAEGDEPYDLVP 434
Cdd:PHA03095  219 DMLGNTPLHSMATGSSckRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMV 298

                          90
                  ....*....|....
gi 119187751  435 SDsENYDKLRTVLA 448
Cdd:PHA03095  299 RN-NNGRAVRAALA 311
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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