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Conserved domains on  [gi|124804377|ref|XP_001347984|]
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60S ribosomal protein P0 [Plasmodium falciparum 3D7]

Protein Classification

uL10 family ribosomal protein( domain architecture ID 11488073)

uL10 family ribosomal protein is an essential element of the ribosomal GTPase-associated center responsible for the interplay with translational factors during various stages of protein synthesis

Gene Ontology:  GO:0003735|GO:0000027
PubMed:  24524803

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PTZ00135 PTZ00135
60S acidic ribosomal protein P0; Provisional
 1-316 4.59e-180

60S acidic ribosomal protein P0; Provisional


:

Pssm-ID: 240285 [Multi-domain]  Cd Length: 310  Bit Score: 499.54  E-value: 4.59e-180
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124804377   1 MAKLSKQQKKQMYIEKLSSLIQQYSKILIVHVDNVGSNQMASVRKSLRGKATILMGKNTRIRTALKKNLQAVPQIEKLLP 80
Cdd:PTZ00135   1 MAKPEKKAKKKAYFEKLYELLEKYKKILIVSVDNVGSKQMQDIRRSLRGKAELLMGKNTLIRKALKQRLEELPELEKLLP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124804377  81 LVKLNMGFVFCKDDLSEIRNIILDNKSPAPARLGVIAPIDVFIPPGPTGMDPSHTSFFQSLGISTKIVKGQIEIQEHVHL 160
Cdd:PTZ00135  81 HVKGNVGFVFTKDDLFEVKPVILENKVPAPARAGVIAPIDVVIPAGPTGMDPSQTSFFQALGIATKIVKGQIEITNEVHL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124804377 161 IKQGEKVTASSATLLQKFNMKPFSYGVDVRTVYDDGVIYDAKVLDITDEDILEKFSKGVSNVAALSRATGVITEASYPHV 240
Cdd:PTZ00135 161 IKEGQKVGASQAVLLQKLNIKPFSYGLEVLSIYDNGSIYDAKVLDITDEDIVAKFQEGVQNVAAISLAAGYPTEASAPHS 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124804377 241 FVEAFKNIVALIIDSDYTFPLMENIKKMVENPEafaavaAPASAAKADEPKKEEAKKVEEEEEEEEDGFMGFGMFD 316
Cdd:PTZ00135 241 ILNAFKNLAAIGLESGFTFPLAEKIKEALANPS------AAAAAAAAAAAAAAAAAAAPAEEEEEEEDDMGFGLFD 310
 
Name Accession Description Interval E-value
PTZ00135 PTZ00135
60S acidic ribosomal protein P0; Provisional
 1-316 4.59e-180

60S acidic ribosomal protein P0; Provisional


Pssm-ID: 240285 [Multi-domain]  Cd Length: 310  Bit Score: 499.54  E-value: 4.59e-180
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124804377   1 MAKLSKQQKKQMYIEKLSSLIQQYSKILIVHVDNVGSNQMASVRKSLRGKATILMGKNTRIRTALKKNLQAVPQIEKLLP 80
Cdd:PTZ00135   1 MAKPEKKAKKKAYFEKLYELLEKYKKILIVSVDNVGSKQMQDIRRSLRGKAELLMGKNTLIRKALKQRLEELPELEKLLP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124804377  81 LVKLNMGFVFCKDDLSEIRNIILDNKSPAPARLGVIAPIDVFIPPGPTGMDPSHTSFFQSLGISTKIVKGQIEIQEHVHL 160
Cdd:PTZ00135  81 HVKGNVGFVFTKDDLFEVKPVILENKVPAPARAGVIAPIDVVIPAGPTGMDPSQTSFFQALGIATKIVKGQIEITNEVHL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124804377 161 IKQGEKVTASSATLLQKFNMKPFSYGVDVRTVYDDGVIYDAKVLDITDEDILEKFSKGVSNVAALSRATGVITEASYPHV 240
Cdd:PTZ00135 161 IKEGQKVGASQAVLLQKLNIKPFSYGLEVLSIYDNGSIYDAKVLDITDEDIVAKFQEGVQNVAAISLAAGYPTEASAPHS 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124804377 241 FVEAFKNIVALIIDSDYTFPLMENIKKMVENPEafaavaAPASAAKADEPKKEEAKKVEEEEEEEEDGFMGFGMFD 316
Cdd:PTZ00135 241 ILNAFKNLAAIGLESGFTFPLAEKIKEALANPS------AAAAAAAAAAAAAAAAAAAPAEEEEEEEDDMGFGLFD 310
Ribosomal_P0_L10e cd05795
Ribosomal protein L10 family, P0 and L10e subfamily; composed of eukaryotic 60S ribosomal ...
 8-182 6.47e-94

Ribosomal protein L10 family, P0 and L10e subfamily; composed of eukaryotic 60S ribosomal protein P0 and the archaeal P0 homolog, L10e. P0 or L10e forms a tight complex with multiple copies of the small acidic protein L12(e). This complex forms a stalk structure on the large subunit of the ribosome. The stalk is known to contain the binding site for elongation factors G and Tu (EF-G and EF-Tu, respectively); however, there is disagreement as to whether or not L10 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, L10 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). These eukaryotic and archaeal P0 sequences have an additional C-terminal domain homologous with acidic proteins P1 and P2.


Pssm-ID: 240221 [Multi-domain]  Cd Length: 175  Bit Score: 275.99  E-value: 6.47e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124804377   8 QKKQMYIEKLSSLIQQYSKILIVHVDNVGSNQMASVRKSLRGKATILMGKNTRIRTALKKNLQAVPQIEKLLPLVKLNMG 87
Cdd:cd05795    1 EWKKEYVEKLTELLKSYPKVLIVDADNVGSKQLQKIRRSLRGKAEILMGKNTLIRRALRNLGDENPELEKLLPYLKGNVG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124804377  88 FVFCKDDLSEIRNIILDNKSPAPARLGVIAPIDVFIPPGPTGMDPSHTSFFQSLGISTKIVKGQIEIQEHVHLIKQGEKV 167
Cdd:cd05795   81 FIFTNGDPFEIRKILEENKVPAPAKPGAIAPCDVVVPAGPTGMPPGPTSFFQALGIPTKIEKGKIEIISDVVVVKKGEKV 160

                        170
                 ....*....|....*
gi 124804377 168 TASSATLLQKFNMKP 182
Cdd:cd05795  161 GASEATLLNKLNIKP 175
RL10P_insert pfam17777
Insertion domain in 60S ribosomal protein L10P; This domain is found in prokaryotic and ...
 111-179 5.40e-24

Insertion domain in 60S ribosomal protein L10P; This domain is found in prokaryotic and archaeal ribosomal L10 protein.


Pssm-ID: 465500 [Multi-domain]  Cd Length: 71  Bit Score: 92.65  E-value: 5.40e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124804377  111 ARLGVIAPIDVFIPPGPTGMDPSHT-SFFQSLGISTKIVKGQIEIQEHVHLIKQGEKVTASSATLLQKFN 179
Cdd:pfam17777   1 ARAGAIATEDVVLPAGPTGLAPGPIePQLRALGIPTKIKKGKIEITKDYTVCKEGEKLTPEQANLLKLLG 70
 
Name Accession Description Interval E-value
PTZ00135 PTZ00135
60S acidic ribosomal protein P0; Provisional
 1-316 4.59e-180

60S acidic ribosomal protein P0; Provisional


Pssm-ID: 240285 [Multi-domain]  Cd Length: 310  Bit Score: 499.54  E-value: 4.59e-180
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124804377   1 MAKLSKQQKKQMYIEKLSSLIQQYSKILIVHVDNVGSNQMASVRKSLRGKATILMGKNTRIRTALKKNLQAVPQIEKLLP 80
Cdd:PTZ00135   1 MAKPEKKAKKKAYFEKLYELLEKYKKILIVSVDNVGSKQMQDIRRSLRGKAELLMGKNTLIRKALKQRLEELPELEKLLP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124804377  81 LVKLNMGFVFCKDDLSEIRNIILDNKSPAPARLGVIAPIDVFIPPGPTGMDPSHTSFFQSLGISTKIVKGQIEIQEHVHL 160
Cdd:PTZ00135  81 HVKGNVGFVFTKDDLFEVKPVILENKVPAPARAGVIAPIDVVIPAGPTGMDPSQTSFFQALGIATKIVKGQIEITNEVHL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124804377 161 IKQGEKVTASSATLLQKFNMKPFSYGVDVRTVYDDGVIYDAKVLDITDEDILEKFSKGVSNVAALSRATGVITEASYPHV 240
Cdd:PTZ00135 161 IKEGQKVGASQAVLLQKLNIKPFSYGLEVLSIYDNGSIYDAKVLDITDEDIVAKFQEGVQNVAAISLAAGYPTEASAPHS 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124804377 241 FVEAFKNIVALIIDSDYTFPLMENIKKMVENPEafaavaAPASAAKADEPKKEEAKKVEEEEEEEEDGFMGFGMFD 316
Cdd:PTZ00135 241 ILNAFKNLAAIGLESGFTFPLAEKIKEALANPS------AAAAAAAAAAAAAAAAAAAPAEEEEEEEDDMGFGLFD 310
Ribosomal_P0_L10e cd05795
Ribosomal protein L10 family, P0 and L10e subfamily; composed of eukaryotic 60S ribosomal ...
 8-182 6.47e-94

Ribosomal protein L10 family, P0 and L10e subfamily; composed of eukaryotic 60S ribosomal protein P0 and the archaeal P0 homolog, L10e. P0 or L10e forms a tight complex with multiple copies of the small acidic protein L12(e). This complex forms a stalk structure on the large subunit of the ribosome. The stalk is known to contain the binding site for elongation factors G and Tu (EF-G and EF-Tu, respectively); however, there is disagreement as to whether or not L10 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, L10 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). These eukaryotic and archaeal P0 sequences have an additional C-terminal domain homologous with acidic proteins P1 and P2.


Pssm-ID: 240221 [Multi-domain]  Cd Length: 175  Bit Score: 275.99  E-value: 6.47e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124804377   8 QKKQMYIEKLSSLIQQYSKILIVHVDNVGSNQMASVRKSLRGKATILMGKNTRIRTALKKNLQAVPQIEKLLPLVKLNMG 87
Cdd:cd05795    1 EWKKEYVEKLTELLKSYPKVLIVDADNVGSKQLQKIRRSLRGKAEILMGKNTLIRRALRNLGDENPELEKLLPYLKGNVG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124804377  88 FVFCKDDLSEIRNIILDNKSPAPARLGVIAPIDVFIPPGPTGMDPSHTSFFQSLGISTKIVKGQIEIQEHVHLIKQGEKV 167
Cdd:cd05795   81 FIFTNGDPFEIRKILEENKVPAPAKPGAIAPCDVVVPAGPTGMPPGPTSFFQALGIPTKIEKGKIEIISDVVVVKKGEKV 160

                        170
                 ....*....|....*
gi 124804377 168 TASSATLLQKFNMKP 182
Cdd:cd05795  161 GASEATLLNKLNIKP 175
PTZ00240 PTZ00240
60S ribosomal protein P0; Provisional
 5-259 7.44e-69

60S ribosomal protein P0; Provisional


Pssm-ID: 140267 [Multi-domain]  Cd Length: 323  Bit Score: 217.52  E-value: 7.44e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124804377   5 SKQQKKQMYIEKLSSLIQQYSKILIVHVDNVGSNQMASVRKSLRGKATILMGKNTRIRTALKKNLQA--VPQIEKLL--- 79
Cdd:PTZ00240   3 SITTAKREYEERLVDCLTKYSCVLFVGMDNVRSQQVHDVRRALRGKAEFVMGKKTLQAKIVEKRAQAkkASAEAKLFndq 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124804377  80 ----PLVKLNMGFVFCKDDLSEIRNIILDNKSPAPARLGVIAPIDVFIPPGPTGMDPSHTSFFQSLGISTKIVKGQIEIQ 155
Cdd:PTZ00240  83 ceekNLLSGNTGLIFTNNEVQEITSVLDSHRVKAPARVGAIAPCDVIVPAGSTGMEPTQTSFFQALNIATKIAKGMVEIV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124804377 156 EHVHLIKQGEKVTASSATLLQKFNMKPFSYGVDVRTVYDDGVIYDAKVLDITDeDILEKF-SKGVSNVAALSRATGVITE 234
Cdd:PTZ00240 163 TEKKVLSVGDKVDNSTATLLQKLNISPFYYQVEVLSVWDRGVLFTREDLSMTE-DVVEKMlMEGLSNVAAMSLGAGIPTA 241

                        250       260
                 ....*....|....*....|....*
gi 124804377 235 ASYPHVFVEAFKNIVALIIDSDYTF 259
Cdd:PTZ00240 242 ATIGPMLVDAFKNLLAVSVATSYEF 266
rplP0 PRK04019
acidic ribosomal protein P0; Validated
 7-257 1.22e-51

acidic ribosomal protein P0; Validated


Pssm-ID: 179712 [Multi-domain]  Cd Length: 330  Bit Score: 173.13  E-value: 1.22e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124804377   7 QQKKQMyIEKLSSLIQQYSKILIVHVDNVGSNQMASVRKSLRGKATILMGKNTRIRTALKKnlQAVPQIEKLLPLVKLNM 86
Cdd:PRK04019   6 EWKKEE-VEELKELIKSYPVVGIVDLEGIPARQLQEIRRKLRGKAELKVSKNTLIKRALEE--AGEEDLEKLEDYLEGQV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124804377  87 GFVFCKDDLSEIRNIILDNKSPAPARLGVIAPIDVFIPPGPTGMDPSH-TSFFQSLGISTKIVKGQIEIQEHVHLIKQGE 165
Cdd:PRK04019  83 ALIFTNMNPFKLYKLLEKSKTPAPAKPGDIAPEDIVVPAGPTGFPPGPiLSELQKLGIPARIQKGKIVIKKDTVVAKAGE 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124804377 166 KVTASSATLLQKFNMKPFSYGVDVRTVYDDGVIYDAKVLDITDEDILEKFSKGVSNVAALSRATGVITEASYPHVFVEAF 245
Cdd:PRK04019 163 VISPELANVLQKLGIKPIEVGLDLKAAYEDGVIYTPEVLAIDEEKYRSDIQEAAQNAFNLAVNAAYPTPETLETLIQKAF 242

                        250
                 ....*....|..
gi 124804377 246 KNIVALIIDSDY 257
Cdd:PRK04019 243 REAKALAVEAGI 254
Ribosomal_L10_P0 cd00379
Ribosomal protein L10 family; composed of the large subunit ribosomal protein called L10 in ...
 8-156 9.85e-27

Ribosomal protein L10 family; composed of the large subunit ribosomal protein called L10 in bacteria, P0 in eukaryotes, and L10e in archaea, as well as uncharacterized P0-like eukaryotic proteins. In all three kingdoms, L10 forms a tight complex with multiple copies of the small acidic protein L12(e). This complex forms a stalk structure on the large subunit of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein and forms the base of the L7/L12 stalk, while the extended C-terminal helix binds to two or three dimers of the NTD of L7/L12 (L7 and L12 are identical except for an acetylated N-terminus). The L7/L12 stalk is known to contain the binding site for elongation factors G and Tu (EF-G and EF-Tu, respectively); however, there is disagreement as to whether or not L10 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, L10 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). Some eukaryotic P0 sequences have an additional C-terminal domain homologous with acidic proteins P1 and P2.


Pssm-ID: 238222 [Multi-domain]  Cd Length: 155  Bit Score: 102.64  E-value: 9.85e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124804377   8 QKKQMYIEKLSSLIQQYSKILIVHVDNVGSNQMASVRKSLRGK-ATILMGKNTRIRTALKKNLqavpqIEKLLPLVKLNM 86
Cdd:cd00379    1 EKKEELVEELKELLKKYKSVVVVDYRGLTVAQLTELRKELRESgAKLKVGKNTLMRRALKGTG-----FEELKPLLKGPT 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124804377  87 GFVFCKDDLSEIRNIILDNKSP---APARLGVIApIDVFIPPGPTGMDPSHTsffQSLGISTKIVKGQIEIQE 156
Cdd:cd00379   76 ALAFTNEDPVEVAKVLKDFAKEnkkLFAKGGVVA-GKVLDPAGVTALAKLPS---REELLAMLIGLLKAPIAK 144
RL10P_insert pfam17777
Insertion domain in 60S ribosomal protein L10P; This domain is found in prokaryotic and ...
 111-179 5.40e-24

Insertion domain in 60S ribosomal protein L10P; This domain is found in prokaryotic and archaeal ribosomal L10 protein.


Pssm-ID: 465500 [Multi-domain]  Cd Length: 71  Bit Score: 92.65  E-value: 5.40e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124804377  111 ARLGVIAPIDVFIPPGPTGMDPSHT-SFFQSLGISTKIVKGQIEIQEHVHLIKQGEKVTASSATLLQKFN 179
Cdd:pfam17777   1 ARAGAIATEDVVLPAGPTGLAPGPIePQLRALGIPTKIKKGKIEITKDYTVCKEGEKLTPEQANLLKLLG 70
Ribosomal_P0_like cd05796
Ribosomal protein L10 family, P0-like protein subfamily; composed of uncharacterized ...
 9-168 2.46e-16

Ribosomal protein L10 family, P0-like protein subfamily; composed of uncharacterized eukaryotic proteins with similarity to the 60S ribosomal protein P0, including the Saccharomyces cerevisiae protein called mRNA turnover protein 4 (MRT4). MRT4 may be involved in mRNA decay. P0 forms a tight complex with multiple copies of the small acidic protein L12(e). This complex forms a stalk structure on the large subunit of the ribosome. It occupies the L7/L12 stalk of the ribosome. The stalk is known to contain the binding site for elongation factors EF-G and EF-Tu; however, there is disagreement as to whether or not P0 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, P0 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). Some eukaryotic P0 sequences have an additional C-terminal domain homologous with acidic proteins P1 and P2.


Pssm-ID: 240222 [Multi-domain]  Cd Length: 163  Bit Score: 74.92  E-value: 2.46e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124804377   9 KKQMYIEKLSSLIQQYSKILIVHVDNVGSNQMASVRKSLRGkATILMGKNTRIRTALKKNL--QAVPQIEKLLPLVKLNM 86
Cdd:cd05796    2 LKQKLVENIREAVDKYKYIYVFSVDNMRNNKLKDIRQEWKD-SRFFFGKNKVMQVALGRTPedEYKPNLHKLSKYLKGQV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124804377  87 GFVFCKDDLSEIRNIILDNKSPAPARLGVIAPIDVFIPPGPtgMDP-SHTSFFQ--SLGISTKIVKGQIEIQEHVHLIKQ 163
Cdd:cd05796   81 GLLFTNEPPEEVIEYFDSYSEPDFARAGSIATETVTLPEGP--LEQfPHSMEPQlrKLGLPTKLKKGVITLEADYVVCEE 158


                 ....*
gi 124804377 164 GEKVT 168
Cdd:cd05796  159 GKVLT 163
Ribosomal_L10 pfam00466
Ribosomal protein L10;
5-105 2.46e-15

Ribosomal protein L10;


Pssm-ID: 459822 [Multi-domain]  Cd Length: 99  Bit Score: 70.26  E-value: 2.46e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124804377    5 SKQQKKQMYIEKLSSLIQQYSKILIVHVDNVGSNQMASVRKSLRGK-ATILMGKNTRIRTALKKNlqavpQIEKLLPLVK 83
Cdd:pfam00466   1 KTREKKEELVEELKELLKEYKSVVVVDYRGLTVAQLTELRKKLRENgAELKVGKNTLMRRALEET-----GEEKLEDYLK 75

                          90       100
                  ....*....|....*....|..
gi 124804377   84 LNMGFVFCKDDLSEIRNIILDN 105
Cdd:pfam00466  76 GPTALLFTNEDPVAVAKVLEDF 97
Ribosomal_L10 cd05797
Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and ...
 8-106 7.65e-06

Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein and forms the base of the L7/L12 stalk, while the extended C-terminal helix binds to two or three dimers of the NTD of L7/L12 (L7 and L12 are identical except for an acetylated N-terminus). The L7/L12 stalk is known to contain the binding site for elongation factors G and Tu (EF-G and EF-Tu, respectively); however, there is disagreement as to whether or not L10 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, L10 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). These bacteria and eukaryotic sequences have no additional C-terminal domain, present in other eukaryotic and archaeal orthologs.


Pssm-ID: 240223  Cd Length: 157  Bit Score: 45.19  E-value: 7.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124804377   8 QKKQMYIEKLSSLIQQYSKILIVHVDNVGSNQMASVRKSLRGK-ATILMGKNTRIRTALKKNlqavpQIEKLLPLVKLNM 86
Cdd:cd05797    3 EKKEEIVAELKEKLKEAKSVVVADYRGLTVAQLTELRKELREAgVKLKVVKNTLAKRALEGT-----GFEDLDDLLKGPT 77

                         90       100
                 ....*....|....*....|
gi 124804377  87 GFVFCKDDLSEIRNIILDNK 106
Cdd:cd05797   78 AIAFSEEDPVAAAKVLKDFA 97
rplJ PRK00099
50S ribosomal protein L10; Reviewed
 4-94 6.26e-04

50S ribosomal protein L10; Reviewed


Pssm-ID: 234632  Cd Length: 172  Bit Score: 39.74  E-value: 6.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124804377   4 LSKQQKKQMyIEKLSSLIQQYSKILIVHVDNVGSNQMASVRKSLRGK-ATILMGKNTRIRTALKKNlqavpQIEKLLPLV 82
Cdd:PRK00099   1 MNREEKKEI-VAELAEKLKKAQSAVVADYRGLTVAQMTELRKKLREAgVEYKVVKNTLARRALEGT-----GFEGLDDLL 74

                         90
                 ....*....|..
gi 124804377  83 KLNMGFVFCKDD 94
Cdd:PRK00099  75 KGPTAIAFSYED 86
Ribosomal_60s pfam00428
60s Acidic ribosomal protein; This family includes archaebacterial L12, eukaryotic P0, P1 and ...
 232-315 6.74e-03

60s Acidic ribosomal protein; This family includes archaebacterial L12, eukaryotic P0, P1 and P2.


Pssm-ID: 459808  Cd Length: 87  Bit Score: 35.31  E-value: 6.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124804377  232 ITEASYPHVFVEAFKNIVALIIDSDYTFPLMENIKKMVENPEAFAAVAAPASAAKADEPKKEEAKKVEEE--EEEEEDGF 309
Cdd:pfam00428   2 PTAANIKKVLKAAGVNVEAVRVKLFAKALEGKNIKELLANGGAKAAAAAAAAAAAAAAAAAAAAAEEKKKeeEEEESDDD 81


                  ....*.
gi 124804377  310 MGFGMF 315
Cdd:pfam00428  82 MGFGLF 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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