NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|124806005|ref|XP_001350600|]
View 

pre-mRNA-processing factor 17, putative [Plasmodium falciparum 3D7]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 321-618 1.82e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 181.76  E-value: 1.82e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806005 321 EIHTYKGHKMGVQKIRFFPKyGNYLLSASLDNTLKLWSvYKSKSCIRTYKGHFKGVKDVLFDNDGSSFLSCSYDNNVIYW 400
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806005 401 DTEYGKIKGIYNQ-KKTPYCLCLNPDdtNTFLVGGANNKICHI-DFRTGNIELEYNEHLQAINTITLCENNKKLISTSDD 478
Cdd:cd00200   79 DLETGECVRTLTGhTSYVSSVAFSPD--GRILSSSSRDKTIKVwDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQD 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806005 479 KKIFIWEYGLPVVVKYISDASMfSITSVSVHPSNNFFLCQSMNNVITVYEATGKFrlfSKKTFKGHHNIGYSINVScsND 558
Cdd:cd00200  157 GTIKLWDLRTGKCVATLTGHTG-EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK---CLGTLRGHENGVNSVAFS--PD 230

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806005 559 GKYVISGDSNGGLFIWNWKKMVNFKNIKAHKNVCIDCVWHPfKTSMLATASWDGTIKLWE 618
Cdd:cd00200  231 GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 321-618 1.82e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 181.76  E-value: 1.82e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806005 321 EIHTYKGHKMGVQKIRFFPKyGNYLLSASLDNTLKLWSvYKSKSCIRTYKGHFKGVKDVLFDNDGSSFLSCSYDNNVIYW 400
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806005 401 DTEYGKIKGIYNQ-KKTPYCLCLNPDdtNTFLVGGANNKICHI-DFRTGNIELEYNEHLQAINTITLCENNKKLISTSDD 478
Cdd:cd00200   79 DLETGECVRTLTGhTSYVSSVAFSPD--GRILSSSSRDKTIKVwDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQD 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806005 479 KKIFIWEYGLPVVVKYISDASMfSITSVSVHPSNNFFLCQSMNNVITVYEATGKFrlfSKKTFKGHHNIGYSINVScsND 558
Cdd:cd00200  157 GTIKLWDLRTGKCVATLTGHTG-EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK---CLGTLRGHENGVNSVAFS--PD 230

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806005 559 GKYVISGDSNGGLFIWNWKKMVNFKNIKAHKNVCIDCVWHPfKTSMLATASWDGTIKLWE 618
Cdd:cd00200  231 GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
320-617 1.09e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.84  E-value: 1.09e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806005 320 KEIHTYKGHKMGVQKIRFFPKyGNYLLSASLDNTLKLWSVyKSKSCIRTYKGHFKGVKDVLFDNDGSSFLSCSYDNNVIY 399
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPD-GKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806005 400 WDTEYGK-IKGIYNQKKTPYCLCLNPDDtNTFLVGGANNKICHIDFRTGNIELEYNEHLQAINTITLCENNKKLISTSDD 478
Cdd:COG2319  189 WDLATGKlLRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806005 479 KKIFIWEYGLPVVVKYISDASmFSITSVSVHPSNNFFLCQSMNNVITVYEATGKFRLfskKTFKGHHNIGYSinVSCSND 558
Cdd:COG2319  268 GTVRLWDLATGELLRTLTGHS-GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL---RTLTGHTGAVRS--VAFSPD 341

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 124806005 559 GKYVISGDSNGGLFIWNWKKMVNFKNIKAHKNVCIDCVWHPfKTSMLATASWDGTIKLW 617
Cdd:COG2319  342 GKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLW 399
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 362-401 1.48e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.48e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 124806005   362 SKSCIRTYKGHFKGVKDVLFDNDGSSFLSCSYDNNVIYWD 401
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
363-401 3.86e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 3.86e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 124806005  363 KSCIRTYKGHFKGVKDVLFDNDGSSFLSCSYDNNVIYWD 401
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 321-618 1.82e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 181.76  E-value: 1.82e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806005 321 EIHTYKGHKMGVQKIRFFPKyGNYLLSASLDNTLKLWSvYKSKSCIRTYKGHFKGVKDVLFDNDGSSFLSCSYDNNVIYW 400
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806005 401 DTEYGKIKGIYNQ-KKTPYCLCLNPDdtNTFLVGGANNKICHI-DFRTGNIELEYNEHLQAINTITLCENNKKLISTSDD 478
Cdd:cd00200   79 DLETGECVRTLTGhTSYVSSVAFSPD--GRILSSSSRDKTIKVwDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQD 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806005 479 KKIFIWEYGLPVVVKYISDASMfSITSVSVHPSNNFFLCQSMNNVITVYEATGKFrlfSKKTFKGHHNIGYSINVScsND 558
Cdd:cd00200  157 GTIKLWDLRTGKCVATLTGHTG-EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK---CLGTLRGHENGVNSVAFS--PD 230

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806005 559 GKYVISGDSNGGLFIWNWKKMVNFKNIKAHKNVCIDCVWHPfKTSMLATASWDGTIKLWE 618
Cdd:cd00200  231 GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
320-617 1.09e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.84  E-value: 1.09e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806005 320 KEIHTYKGHKMGVQKIRFFPKyGNYLLSASLDNTLKLWSVyKSKSCIRTYKGHFKGVKDVLFDNDGSSFLSCSYDNNVIY 399
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPD-GKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806005 400 WDTEYGK-IKGIYNQKKTPYCLCLNPDDtNTFLVGGANNKICHIDFRTGNIELEYNEHLQAINTITLCENNKKLISTSDD 478
Cdd:COG2319  189 WDLATGKlLRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806005 479 KKIFIWEYGLPVVVKYISDASmFSITSVSVHPSNNFFLCQSMNNVITVYEATGKFRLfskKTFKGHHNIGYSinVSCSND 558
Cdd:COG2319  268 GTVRLWDLATGELLRTLTGHS-GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL---RTLTGHTGAVRS--VAFSPD 341

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 124806005 559 GKYVISGDSNGGLFIWNWKKMVNFKNIKAHKNVCIDCVWHPfKTSMLATASWDGTIKLW 617
Cdd:COG2319  342 GKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
320-618 1.16e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.59  E-value: 1.16e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806005 320 KEIHTYKGHKMGVQKIRFFPKyGNYLLSASLDNTLKLWSVyKSKSCIRTYKGHFKGVKDVLFDNDGSSFLSCSYDNNVIY 399
Cdd:COG2319   69 ALLATLLGHTAAVLSVAFSPD-GRLLASASADGTVRLWDL-ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806005 400 WDTEYGK-IKGIYNQKKTPYCLCLNPDDTnTFLVGGANNKICHIDFRTGNIELEYNEHLQAINTITLCENNKKLISTSDD 478
Cdd:COG2319  147 WDLATGKlLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSAD 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806005 479 KKIFIWEYGLPVVVKYISDASmFSITSVSVHPSNNFFLCQSMNNVITVYEATGKFRLfskKTFKGHHNIGYSinVSCSND 558
Cdd:COG2319  226 GTVRLWDLATGKLLRTLTGHS-GSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL---RTLTGHSGGVNS--VAFSPD 299

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806005 559 GKYVISGDSNGGLFIWNWKKMVNFKNIKAHKNVCIDCVWHPfKTSMLATASWDGTIKLWE 618
Cdd:COG2319  300 GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWD 358
WD40 COG2319
WD40 repeat [General function prediction only];
320-575 7.45e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.80  E-value: 7.45e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806005 320 KEIHTYKGHKMGVQKIRFFPKyGNYLLSASLDNTLKLWSVyKSKSCIRTYKGHFKGVKDVLFDNDGSSFLSCSYDNNVIY 399
Cdd:COG2319  153 KLLRTLTGHSGAVTSVAFSPD-GKLLASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRL 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806005 400 WDTEYGKIKGIYN-QKKTPYCLCLNPDDTnTFLVGGANNKICHIDFRTGNIELEYNEHLQAINTITLCENNKKLISTSDD 478
Cdd:COG2319  231 WDLATGKLLRTLTgHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806005 479 KKIFIWEYGLPVVVKYISDASMfSITSVSVHPSNNFFLCQSMNNVITVYEATGKFRLfskKTFKGHHNIGYSinVSCSND 558
Cdd:COG2319  310 GTVRLWDLATGKLLRTLTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL---RTLTGHTGAVTS--VAFSPD 383

                        250
                 ....*....|....*..
gi 124806005 559 GKYVISGDSNGGLFIWN 575
Cdd:COG2319  384 GRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
342-617 1.33e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.51  E-value: 1.33e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806005 342 GNYLLSASLDNTLKLWSVyKSKSCIRTYKGHFKGVKDVLFDNDGSSFLSCSYDNNVIYWDTEYGKIKGIYNQKKTPYCLC 421
Cdd:COG2319    6 GAALAAASADLALALLAA-ALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806005 422 LNPDDTNTFLVGGANNKICHIDFRTGNIELEYNEHLQAINTITLCENNKKLISTSDDKKIFIWEYGLPVVVKYISDASmF 501
Cdd:COG2319   85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHS-G 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806005 502 SITSVSVHPSNNFFLCQSMNNVITVYE-ATGKFRlfskKTFKGHHNIGYSinVSCSNDGKYVISGDSNGGLFIWNWKKMV 580
Cdd:COG2319  164 AVTSVAFSPDGKLLASGSDDGTVRLWDlATGKLL----RTLTGHTGAVRS--VAFSPDGKLLASGSADGTVRLWDLATGK 237

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 124806005 581 NFKNIKAHKNVCIDCVWHPfKTSMLATASWDGTIKLW 617
Cdd:COG2319  238 LLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
320-403 2.13e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 2.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124806005 320 KEIHTYKGHKMGVQKIRFFPKyGNYLLSASLDNTLKLWSVyKSKSCIRTYKGHFKGVKDVLFDNDGSSFLSCSYDNNVIY 399
Cdd:COG2319  321 KLLRTLTGHTGAVRSVAFSPD-GKTLASGSDDGTVRLWDL-ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398


                 ....
gi 124806005 400 WDTE 403
Cdd:COG2319  399 WDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 362-401 1.48e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.48e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 124806005   362 SKSCIRTYKGHFKGVKDVLFDNDGSSFLSCSYDNNVIYWD 401
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
363-401 3.86e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 3.86e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 124806005  363 KSCIRTYKGHFKGVKDVLFDNDGSSFLSCSYDNNVIYWD 401
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 318-358 5.69e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 5.69e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 124806005   318 PKKEIHTYKGHKMGVQKIRFFPkYGNYLLSASLDNTLKLWS 358
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
319-358 9.27e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 9.27e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 124806005  319 KKEIHTYKGHKMGVQKIRFFPKyGNYLLSASLDNTLKLWS 358
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 583-618 6.71e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 6.71e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 124806005   583 KNIKAHKNVCIDCVWHPFKtSMLATASWDGTIKLWE 618
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
583-618 7.57e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 7.57e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 124806005  583 KNIKAHKNVCIDCVWHPFKTsMLATASWDGTIKLWE 618
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 446-485 7.92e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 7.92e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 124806005   446 TGNIELEYNEHLQAINTITLCENNKKLISTSDDKKIFIWE 485
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH