|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
90-507 |
2.11e-108 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 335.19 E-value: 2.11e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 90 SDLYISRPFLKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLLQSVNIKMRrnnmkgsynit 169
Cdd:COG0513 5 ADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDPSRPRAPQ----------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 170 kALILLPTRELSLQCYDVIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNSSSDFiNYLEIVVF 249
Cdd:COG0513 74 -ALILAPTRELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERGALDL-SGVETLVL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 250 DEADKLLELGFKEECLKILDVCKFKKQILFFSATLTSDIKQLANFSLKNPVFIQsgmsfdknVDGKNTynayntcntynd 329
Cdd:COG0513 152 DEADRMLDMGFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIE--------VAPENA------------ 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 330 ndnnnivvnniisnsflkisnkasfkISENLKQEFVNIiqEKYRKASLLY--LCNNIYKNhCIIFFKTKRETHlmyLLFD 407
Cdd:COG0513 212 --------------------------TAETIEQRYYLV--DKRDKLELLRrlLRDEDPER-AIVFCNTKRGAD---RLAE 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 408 LLN---LRCAELHGSMSQKKRIESIMKFKKAEVDFLLTTELASRGIDIDHVLYVINYNVPSNVIKYVHRIGRTARIGKEG 484
Cdd:COG0513 260 KLQkrgISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVINYDLPEDPEDYVHRIGRTGRAGAEG 339
|
410 420
....*....|....*....|...
gi 1371547147 485 IASTLYLQKEKIEVKKIVKGLKK 507
Cdd:COG0513 340 TAISLVTPDERRLLRAIEKLIGQ 362
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
99-303 |
1.24e-78 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 249.48 E-value: 1.24e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 99 LKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLLqsvnikmRRNNMKGSyniTKALILLPTR 178
Cdd:cd17947 2 LRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLL-------YRPKKKAA---TRVLVLVPTR 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 179 ELSLQCYDVIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNSSSDFINYLEIVVFDEADKLLEL 258
Cdd:cd17947 72 ELAMQCFSVLQQLAQFTDITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDHLRNSPSFDLDSIEILVLDEADRMLEE 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1371547147 259 GFKEECLKILDVCKFKKQILFFSATLTSDIKQLANFSLKNPVFIQ 303
Cdd:cd17947 152 GFADELKEILRLCPRTRQTMLFSATMTDEVKDLAKLSLNKPVRVF 196
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
99-303 |
1.25e-71 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 231.18 E-value: 1.25e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 99 LKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLLQSVNIKMRRnnmkgsyniTKALILLPTR 178
Cdd:cd00268 2 LKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPKKKGRG---------PQALVLAPTR 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 179 ELSLQCYDVIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNSSSDFiNYLEIVVFDEADKLLEL 258
Cdd:cd00268 73 ELAMQIAEVARKLGKGTGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERGKLDL-SNVKYLVLDEADRMLDM 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1371547147 259 GFKEECLKILDVCKFKKQILFFSATLTSDIKQLANFSLKNPVFIQ 303
Cdd:cd00268 152 GFEEDVEKILSALPKDRQTLLFSATLPEEVKELAKKFLKNPVRIE 196
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
89-536 |
2.37e-65 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 222.51 E-value: 2.37e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 89 WSDLYISRPFLKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLLQSVnikmRRNNmkGSYNI 168
Cdd:PRK11192 3 FSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLDFP----RRKS--GPPRI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 169 tkaLILLPTRELSLQCYDVIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNSSSDfINYLEIVV 248
Cdd:PRK11192 77 ---LILTPTRELAMQVADQARELAKHTHLDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIKEENFD-CRAVETLI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 249 FDEADKLLELGFKEECLKILDVCKFKKQILFFSATLTSD-IKQLANFSLKNPVFIQSgmsfdknvdgkntynayntcnty 327
Cdd:PRK11192 153 LDEADRMLDMGFAQDIETIAAETRWRKQTLLFSATLEGDaVQDFAERLLNDPVEVEA----------------------- 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 328 ndndnnnivvnniisnsflKISNKASFKIsenlkQEFVNIIQEKYRKASLlyLCNNIYKNHC---IIFFKTKRETHlmyL 404
Cdd:PRK11192 210 -------------------EPSRRERKKI-----HQWYYRADDLEHKTAL--LCHLLKQPEVtrsIVFVRTRERVH---E 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 405 LFDLL---NLRCAELHGSMSQKKRIESIMKFKKAEVDFLLTTELASRGIDIDHVLYVINYNVPSNVIKYVHRIGRTARIG 481
Cdd:PRK11192 261 LAGWLrkaGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDVAARGIDIDDVSHVINFDMPRSADTYLHRIGRTGRAG 340
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1371547147 482 KEGIASTL-----YLQKEKIE------VK-KIVKGLK-KSKNLKILKRTIAENNVLVWYKIIKENKQK 536
Cdd:PRK11192 341 RKGTAISLveahdHLLLGKIEryieepLKaRVIDELRpKTKAPSEKKTGKPSKKVLAKRAEKKEKEKE 408
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
92-507 |
4.76e-62 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 214.29 E-value: 4.76e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 92 LYISRPFLKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLLQS-VNIKMRRNnmkgsyniTK 170
Cdd:PRK10590 6 LGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRqPHAKGRRP--------VR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 171 ALILLPTRELSLQCYDVIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNSSSDfINYLEIVVFD 250
Cdd:PRK10590 78 ALILTPTRELAAQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQNAVK-LDQVEILVLD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 251 EADKLLELGFKEECLKILDVCKFKKQILFFSATLTSDIKQLANFSLKNPVFIQsgmsfdknVDGKNTynayntcntyndn 330
Cdd:PRK10590 157 EADRMLDMGFIHDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIE--------VARRNT------------- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 331 dnnnivvnniisnsflkisnkASFKISENLkqEFVniiqEKYRKASLL-YLCNNIYKNHCIIFFKTKretHLMYLLFDLL 409
Cdd:PRK10590 216 ---------------------ASEQVTQHV--HFV----DKKRKRELLsQMIGKGNWQQVLVFTRTK---HGANHLAEQL 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 410 N---LRCAELHGSMSQKKRIESIMKFKKAEVDFLLTTELASRGIDIDHVLYVINYNVPSNVIKYVHRIGRTARIGKEGIA 486
Cdd:PRK10590 266 NkdgIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPHVVNYELPNVPEDYVHRIGRTGRAAATGEA 345
|
410 420
....*....|....*....|.
gi 1371547147 487 STLYLQKEKIEVKKIVKGLKK 507
Cdd:PRK10590 346 LSLVCVDEHKLLRDIEKLLKK 366
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
99-302 |
1.13e-54 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 185.96 E-value: 1.13e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 99 LKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLLQsvnikmrrnNMKGSYNITKALILLPTR 178
Cdd:cd17941 2 LKGLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLYR---------ERWTPEDGLGALIISPTR 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 179 ELSLQCYDVIRSLTKYVTITYSLFCGGIDIKqQEYEFKKRNDIFVCTPGRILDLLLNSSSDFINYLEIVVFDEADKLLEL 258
Cdd:cd17941 73 ELAMQIFEVLRKVGKYHSFSAGLIIGGKDVK-EEKERINRMNILVCTPGRLLQHMDETPGFDTSNLQMLVLDEADRILDM 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1371547147 259 GFKEECLKILDVCKFKKQILFFSATLTSDIKQLANFSLKNPVFI 302
Cdd:cd17941 152 GFKETLDAIVENLPKSRQTLLFSATQTKSVKDLARLSLKNPEYI 195
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
90-501 |
4.45e-50 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 181.54 E-value: 4.45e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 90 SDLYISRPFLKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPilerLLQSVNIKMRRnnmkgsyniT 169
Cdd:PRK11776 7 STLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLG----LLQKLDVKRFR---------V 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 170 KALILLPTRELSLQCYDVIRSL------TKYVTItyslfCGGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNSSSDFINy 243
Cdd:PRK11776 74 QALVLCPTRELADQVAKEIRRLarfipnIKVLTL-----CGGVPMGPQIDSLEHGAHIIVGTPGRILDHLRKGTLDLDA- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 244 LEIVVFDEADKLLELGFKEECLKILDVCKFKKQILFFSATLTSDIKQLANFSLKNPVFIQsgmsfdknVDGKNTYNAynt 323
Cdd:PRK11776 148 LNTLVLDEADRMLDMGFQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVK--------VESTHDLPA--- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 324 cntyndndnnnivvnniISNSFlkisnkasFKISENLKQEFVNIIQEKYRKASllylcnniyknhCIIFFKTKRETHlmy 403
Cdd:PRK11776 217 -----------------IEQRF--------YEVSPDERLPALQRLLLHHQPES------------CVVFCNTKKECQ--- 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 404 LLFDLLNLR---CAELHGSMSQKKRIESIMKF--KKAEVdfLLTTELASRGIDIDHVLYVINYNVPSNVIKYVHRIGRTA 478
Cdd:PRK11776 257 EVADALNAQgfsALALHGDLEQRDRDQVLVRFanRSCSV--LVATDVAARGLDIKALEAVINYELARDPEVHVHRIGRTG 334
|
410 420
....*....|....*....|...
gi 1371547147 479 RIGKEGIASTLYLQKEKIEVKKI 501
Cdd:PRK11776 335 RAGSKGLALSLVAPEEMQRANAI 357
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
99-302 |
6.03e-50 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 172.93 E-value: 6.03e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 99 LKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILErLLQSVNIKMRrnnmkgsyNITKALILLPTR 178
Cdd:cd17942 2 LKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIE-LLYKLKFKPR--------NGTGVIIISPTR 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 179 ELSLQCYDVIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNSSSDFINYLEIVVFDEADKLLEL 258
Cdd:cd17942 73 ELALQIYGVAKELLKYHSQTFGIVIGGANRKAEAEKLGKGVNILVATPGRLLDHLQNTKGFLYKNLQCLIIDEADRILEI 152
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1371547147 259 GFKEECLKILDVCKFKKQILFFSATLTSDIKQLANFSLKN-PVFI 302
Cdd:cd17942 153 GFEEEMRQIIKLLPKRRQTMLFSATQTRKVEDLARISLKKkPLYV 197
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
94-303 |
8.43e-50 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 172.87 E-value: 8.43e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 94 ISRPFLKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLlqsvnikMRRNNMKGsyniTKALI 173
Cdd:cd17959 8 LSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKL-------KAHSPTVG----ARALI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 174 LLPTRELSLQCYDVIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNSSSDFINyLEIVVFDEAD 253
Cdd:cd17959 77 LSPTRELALQTLKVTKELGKFTDLRTALLVGGDSLEEQFEALASNPDIIIATPGRLLHLLVEMNLKLSS-VEYVVFDEAD 155
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1371547147 254 KLLELGFKEECLKILDVCKFKKQILFFSATLTSDIKQLANFSLKNPVFIQ 303
Cdd:cd17959 156 RLFEMGFAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVLIR 205
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
106-302 |
5.30e-49 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 171.23 E-value: 5.30e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 106 KFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERlLQSVNIKMRRNnmKGSYnitkALILLPTRELSLQCY 185
Cdd:cd17949 10 GIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQR-LLSLEPRVDRS--DGTL----ALVLVPTRELALQIY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 186 DVIRSLTKYVT-ITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNSSSDFINYLEIVVFDEADKLLELGFKEEC 264
Cdd:cd17949 83 EVLEKLLKPFHwIVPGYLIGGEKRKSEKARLRKGVNILIATPGRLLDHLKNTQSFDVSNLRWLVLDEADRLLDMGFEKDI 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1371547147 265 LKILD-------------VCKFKKQILFFSATLTSDIKQLANFSLKNPVFI 302
Cdd:cd17949 163 TKILEllddkrskaggekSKPSRRQTVLVSATLTDGVKRLAGLSLKDPVYI 213
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
91-486 |
7.53e-49 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 178.57 E-value: 7.53e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 91 DLYISRPFLKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLLQSVNIKMRrnnMKGSyniTK 170
Cdd:PRK01297 91 DFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQTPPPKER---YMGE---PR 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 171 ALILLPTRELSLQCYDVIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRN-DIFVCTPGRILDllLNSSSD-FINYLEIVV 248
Cdd:PRK01297 165 ALIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEARFcDILVATPGRLLD--FNQRGEvHLDMVEVMV 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 249 FDEADKLLELGFKEECLKILDVC--KFKKQILFFSATLTSDIKQLANFSLKNPVFIQsgmsfdknvdgkntynayntcnt 326
Cdd:PRK01297 243 LDEADRMLDMGFIPQVRQIIRQTprKEERQTLLFSATFTDDVMNLAKQWTTDPAIVE----------------------- 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 327 yndndnnnivvnniisnsfLKISNKAsfkiSENLKQE-FVNIIQEKYRkasLLYlcNNIYKN---HCIIFFKTKRETHLM 402
Cdd:PRK01297 300 -------------------IEPENVA----SDTVEQHvYAVAGSDKYK---LLY--NLVTQNpweRVMVFANRKDEVRRI 351
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 403 YLLFDLLNLRCAELHGSMSQKKRIESIMKFKKAEVDFLLTTELASRGIDIDHVLYVINYNVPSNVIKYVHRIGRTARIGK 482
Cdd:PRK01297 352 EERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGA 431
|
....
gi 1371547147 483 EGIA 486
Cdd:PRK01297 432 SGVS 435
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
89-303 |
1.40e-48 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 169.42 E-value: 1.40e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 89 WSDLYISRPFLKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLLqsvnikmrrNNMKGSYni 168
Cdd:cd17954 2 FKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALL---------ENPQRFF-- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 169 tkALILLPTRELSLQCYDVIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNSSSDFINYLEIVV 248
Cdd:cd17954 71 --ALVLAPTRELAQQISEQFEALGSSIGLKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDHLENTKGFSLKSLKFLV 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1371547147 249 FDEADKLLELGFKEECLKILDVCKFKKQILFFSATLTSDIKQLANFSLKNPVFIQ 303
Cdd:cd17954 149 MDEADRLLNMDFEPEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNPVKIE 203
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
90-303 |
2.91e-48 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 168.56 E-value: 2.91e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 90 SDLYISRPFLKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLlqsvnikmrrnnMKGSYNIT 169
Cdd:cd17955 2 EDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRL------------SEDPYGIF 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 170 kALILLPTRELSLQCYDVIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDlLLNSSSDFINYLEIV-- 247
Cdd:cd17955 70 -ALVLTPTRELAYQIAEQFRALGAPLGLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLAD-HLRSSDDTTKVLSRVkf 147
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1371547147 248 -VFDEADKLLELGFKEECLKILDVCKFKKQILFFSATLTSDIKQLANFSLKNPVFIQ 303
Cdd:cd17955 148 lVLDEADRLLTGSFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKPFFWE 204
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
99-300 |
7.08e-48 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 167.76 E-value: 7.08e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 99 LKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLLqsvnikmRRNNMKGSYNITKALILLPTR 178
Cdd:cd17961 6 LKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKIL-------KAKAESGEEQGTRALILVPTR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 179 ELSLQCYDVIRSLTKYVTITYSLfcggIDIKQQEYEFKKRN------DIFVCTPGRILDLLLNSSSDFINYLEIVVFDEA 252
Cdd:cd17961 79 ELAQQVSKVLEQLTAYCRKDVRV----VNLSASSSDSVQRAllaekpDIVVSTPARLLSHLESGSLLLLSTLKYLVIDEA 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1371547147 253 DKLLELGFKEECLKILDVCKFKKQILFFSATLTSDIKQLANFSLKNPV 300
Cdd:cd17961 155 DLVLSYGYEEDLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPA 202
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
110-508 |
1.64e-47 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 175.75 E-value: 1.64e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 110 PTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILER--LLQSVNIKMRRNNMkgsynitkALILLPTRELSLQCYDV 187
Cdd:PLN00206 144 PTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRccTIRSGHPSEQRNPL--------AMVLTPTRELCVQVEDQ 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 188 IRSLTKYVTITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNSSSDfINYLEIVVFDEADKLLELGFKEECLKI 267
Cdd:PLN00206 216 AKVLGKGLPFKTALVVGGDAMPQQLYRIQQGVELIVGTPGRLIDLLSKHDIE-LDNVSVLVLDEVDCMLERGFRDQVMQI 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 268 LDVCKfKKQILFFSATLTSDIKQLANFSLKNPVFIQSGMSFDKNVDGKNTynayntcntyndndnnnivvnniisnsflk 347
Cdd:PLN00206 295 FQALS-QPQVLLFSATVSPEVEKFASSLAKDIILISIGNPNRPNKAVKQL------------------------------ 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 348 isnkASFKISENLKQEFVNIIQEKYRkasllylcnniYKNHCIIFFKTKrethlmyLLFDLLN--------LRCAELHGS 419
Cdd:PLN00206 344 ----AIWVETKQKKQKLFDILKSKQH-----------FKPPAVVFVSSR-------LGADLLAnaitvvtgLKALSIHGE 401
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 420 MSQKKRIESIMKFKKAEVDFLLTTELASRGIDIDHVLYVINYNVPSNVIKYVHRIGRTARIGKEGIASTLYLQKEKIEVK 499
Cdd:PLN00206 402 KSMKERREVMKSFLVGEVPVIVATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFVNEEDRNLFP 481
|
....*....
gi 1371547147 500 KIVKGLKKS 508
Cdd:PLN00206 482 ELVALLKSS 490
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
93-509 |
1.66e-47 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 176.50 E-value: 1.66e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 93 YISRP--FLKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILerllqsVNIKMRRNNMKGSYNItk 170
Cdd:PTZ00110 134 YTSFPdyILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAI------VHINAQPLLRYGDGPI-- 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 171 ALILLPTRELSLQCYDVIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNSSSDF--INYLeivV 248
Cdd:PTZ00110 206 VLVLAPTRELAEQIREQCNKFGASSKIRNTVAYGGVPKRGQIYALRRGVEILIACPGRLIDFLESNVTNLrrVTYL---V 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 249 FDEADKLLELGFKEECLKILDVCKFKKQILFFSATLTSDIKQLANFSLKN-PVFIQSGmSFDknvdgkntynayntcnty 327
Cdd:PTZ00110 283 LDEADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVQSLARDLCKEePVHVNVG-SLD------------------ 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 328 ndndnnnivvnniisnsflkisnkasFKISENLKQEfVNIIQEKYRKASLLYLCNNIYKN--HCIIFFKTKRETHLMYLL 405
Cdd:PTZ00110 344 --------------------------LTACHNIKQE-VFVVEEHEKRGKLKMLLQRIMRDgdKILIFVETKKGADFLTKE 396
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 406 FDLLNLRCAELHGSMSQKKRIESIMKFKKAEVDFLLTTELASRGIDIDHVLYVINYNVPSNVIKYVHRIGRTARIGKEGI 485
Cdd:PTZ00110 397 LRLDGWPALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGA 476
|
410 420
....*....|....*....|....*
gi 1371547147 486 ASTlYLQKEKIEV-KKIVKGLKKSK 509
Cdd:PTZ00110 477 SYT-FLTPDKYRLaRDLVKVLREAK 500
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
111-291 |
1.74e-47 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 165.11 E-value: 1.74e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 111 TYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLlqsvnikmrRNNMKGsyniTKALILLPTRELSLQCYDVIRS 190
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEAL---------DKLDNG----PQALVLAPTRELAEQIYEELKK 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 191 LTKYVTITYSLFCGGIDIKQQEYEFKKrNDIFVCTPGRILDLLLNSSsdFINYLEIVVFDEADKLLELGFKEECLKILDV 270
Cdd:pfam00270 68 LGKGLGLKVASLLGGDSRKEQLEKLKG-PDILVGTPGRLLDLLQERK--LLKNLKLLVLDEAHRLLDMGFGPDLEEILRR 144
|
170 180
....*....|....*....|.
gi 1371547147 271 CKFKKQILFFSATLTSDIKQL 291
Cdd:pfam00270 145 LPKKRQILLLSATLPRNLEDL 165
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
99-302 |
4.71e-47 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 165.44 E-value: 4.71e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 99 LKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLLqsvnikmrrnnmKGSYNITK----ALIL 174
Cdd:cd17960 2 LDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILL------------KRKANLKKgqvgALII 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 175 LPTRELSLQCYDVIRSLTKYVT--ITYSLFCGGIDIKQQEYEFKKRN-DIFVCTPGRILDlLLNSSSDFINY--LEIVVF 249
Cdd:cd17960 70 SPTRELATQIYEVLQSFLEHHLpkLKCQLLIGGTNVEEDVKKFKRNGpNILVGTPGRLEE-LLSRKADKVKVksLEVLVL 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1371547147 250 DEADKLLELGFKEECLKILDvcKFKKQ--ILFFSATLTSDIKQLANFSLKNPVFI 302
Cdd:cd17960 149 DEADRLLDLGFEADLNRILS--KLPKQrrTGLFSATQTDAVEELIKAGLRNPVRV 201
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
102-302 |
2.10e-44 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 157.75 E-value: 2.10e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 102 LYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLLqsvnikmRRNNMKGsyniTKALILLPTRELS 181
Cdd:cd17957 5 LEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLG-------KPRKKKG----LRALILAPTRELA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 182 LQCYDVIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRN-DIFVCTPGRILDLLLNSSSDFINyLEIVVFDEADKLLELGF 260
Cdd:cd17957 74 SQIYRELLKLSKGTGLRIVLLSKSLEAKAKDGPKSITKyDILVSTPLRLVFLLKQGPIDLSS-VEYLVLDEADKLFEPGF 152
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1371547147 261 KEECLKILDVCKFKK-QILFFSATLTSDIKQLANFSLKNPVFI 302
Cdd:cd17957 153 REQTDEILAACTNPNlQRSLFSATIPSEVEELARSVMKDPIRI 195
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
90-486 |
2.69e-44 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 164.37 E-value: 2.69e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 90 SDLYISRPFLKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLLQSVNIKMRRNNMKgsynit 169
Cdd:PRK04837 11 SDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYLLSHPAPEDRKVNQP------ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 170 KALILLPTRELSLQCYDVIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNSSSDFiNYLEIVVF 249
Cdd:PRK04837 85 RALIMAPTRELAVQIHADAEPLAQATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINL-GAIQVVVL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 250 DEADKLLELGFKEECLKILDVCKFKKQIL--FFSATLTSDIKQLANFSLKNPVFIQsgmsfdknvdgkntynayntcnty 327
Cdd:PRK04837 164 DEADRMFDLGFIKDIRWLFRRMPPANQRLnmLFSATLSYRVRELAFEHMNNPEYVE------------------------ 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 328 ndndnnnivvnniisnsfLKISNKASFKISENLkqeFVNIIQEKYRkaSLLYLCNNIYKNHCIIFFKTKR--ETHLMYLL 405
Cdd:PRK04837 220 ------------------VEPEQKTGHRIKEEL---FYPSNEEKMR--LLQTLIEEEWPDRAIIFANTKHrcEEIWGHLA 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 406 FDllNLRCAELHGSMSQKKRIESIMKFKKAEVDFLLTTELASRGIDIDHVLYVINYNVPSNVIKYVHRIGRTARIGKEGI 485
Cdd:PRK04837 277 AD--GHRVGLLTGDVAQKKRLRILEEFTRGDLDILVATDVAARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGH 354
|
.
gi 1371547147 486 A 486
Cdd:PRK04837 355 S 355
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
360-490 |
1.38e-43 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 153.05 E-value: 1.38e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 360 LKQEFVNIIQEKYRKASLLYLCNNIYKNHCIIFFKTKRETHLMYLLFDLLNLRCAELHGSMSQKKRIESIMKFKKAEVDF 439
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1371547147 440 LLTTELASRGIDIDHVLYVINYNVPSNVIKYVHRIGRTARIGKEGIASTLY 490
Cdd:cd18787 81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
89-303 |
9.27e-43 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 154.07 E-value: 9.27e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 89 WSDLYISRPFLKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILErllqsvNIKMRRNNMKGSYNI 168
Cdd:cd17953 14 WSQCGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFR------HIKDQRPVKPGEGPI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 169 tkALILLPTRELSLQCYDVIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNSSSDFINYLEI-- 246
Cdd:cd17953 88 --GLIMAPTRELALQIYVECKKFSKALGLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDILTANNGRVTNLRRVty 165
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1371547147 247 VVFDEADKLLELGFKEECLKILDVCKFKKQILFFSATLTSDIKQLANFSLKNPVFIQ 303
Cdd:cd17953 166 VVLDEADRMFDMGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKPIEIT 222
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
89-302 |
1.72e-42 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 152.84 E-value: 1.72e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 89 WSDLYISRPFLKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLLQSvnikmrrnnmkgSYNI 168
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKIDPK------------KDVI 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 169 tKALILLPTRELSLQCYDVIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNSSSDFiNYLEIVV 248
Cdd:cd17940 69 -QALILVPTRELALQTSQVCKELGKHMGVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGVADL-SHCKTLV 146
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1371547147 249 FDEADKLLELGFKEECLKILDVCKFKKQILFFSATLTSDIKQLANFSLKNPVFI 302
Cdd:cd17940 147 LDEADKLLSQDFQPIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNPYEI 200
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
107-486 |
5.56e-42 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 161.27 E-value: 5.56e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 107 FSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLLQSVNIKMRRNNMKgsynitKALILLPTRELSLQCYD 186
Cdd:PRK04537 29 FTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSRPALADRKPEDP------RALILAPTRELAIQIHK 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 187 VIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNSSSDFINYLEIVVFDEADKLLELGFKEECLK 266
Cdd:PRK04537 103 DAVKFGADLGLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQHKVVSLHACEICVLDEADRMFDLGFIKDIRF 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 267 ILDVC--KFKKQILFFSATLTSDIKQLANFSLKNPvfiqsgmsfDKNVDGKNTYNAyntcntyndndnnnivvnniisns 344
Cdd:PRK04537 183 LLRRMpeRGTRQTLLFSATLSHRVLELAYEHMNEP---------EKLVVETETITA------------------------ 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 345 fLKISNKASFKiSENLKQEFvniiqekyrkasLLYLCNNIYKNHCIIFFKTKRETHLMYLLFDLLNLRCAELHGSMSQKK 424
Cdd:PRK04537 230 -ARVRQRIYFP-ADEEKQTL------------LLGLLSRSEGARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKK 295
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1371547147 425 RIESIMKFKKAEVDFLLTTELASRGIDIDHVLYVINYNVPSNVIKYVHRIGRTARIGKEGIA 486
Cdd:PRK04537 296 RESLLNRFQKGQLEILVATDVAARGLHIDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDA 357
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
94-303 |
1.71e-41 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 150.43 E-value: 1.71e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 94 ISRPFLKVLYEQKFSNPTYIQRDVIPLALE-GKSILANSETGSGKTLAFVLPILERLLQSvnIKMRRNNMkgsyniTKAL 172
Cdd:cd17964 1 LDPSLLKALTRMGFETMTPVQQKTLKPILStGDDVLARAKTGTGKTLAFLLPAIQSLLNT--KPAGRRSG------VSAL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 173 ILLPTRELSLQCYDVIRSLTKYVT-ITYSLFCGGIDIKQQEYEFKKRN-DIFVCTPGRILDLLLNSSS--DFINyLEIVV 248
Cdd:cd17964 73 IISPTRELALQIAAEAKKLLQGLRkLRVQSAVGGTSRRAELNRLRRGRpDILVATPGRLIDHLENPGVakAFTD-LDYLV 151
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 249 FDEADKLLELGFKEECLKILD----VCKFKKQILFFSATLTSDIKQLANFSL-KNPVFIQ 303
Cdd:cd17964 152 LDEADRLLDMGFRPDLEQILRhlpeKNADPRQTLLFSATVPDEVQQIARLTLkKDYKFID 211
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
89-506 |
2.25e-41 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 160.01 E-value: 2.25e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 89 WSDLYISRPFLKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILerllqsvnikmrrNNMKGSYNI 168
Cdd:PRK11634 8 FADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLL-------------HNLDPELKA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 169 TKALILLPTRELSLQCYDVIRSLTKYV-TITYSLFCGGidikqQEYEFKKRN-----DIFVCTPGRILDLLLNSSSDFIN 242
Cdd:PRK11634 75 PQILVLAPTRELAVQVAEAMTDFSKHMrGVNVVALYGG-----QRYDVQLRAlrqgpQIVVGTPGRLLDHLKRGTLDLSK 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 243 yLEIVVFDEADKLLELGFKEECLKILDVCKFKKQILFFSATLTSDIKQLANFSLKNP--VFIQSGMSFDKNVDgkntyNA 320
Cdd:PRK11634 150 -LSGLVLDEADEMLRMGFIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPqeVRIQSSVTTRPDIS-----QS 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 321 YNTCNTYNDndnnnivvnniisnsflkisNKASFKISEnlkqefvniiQEKYRKAsllylcnniyknhcIIFFKTKRETH 400
Cdd:PRK11634 224 YWTVWGMRK--------------------NEALVRFLE----------AEDFDAA--------------IIFVRTKNATL 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 401 LMYLLFDLLNLRCAELHGSMSQKKRIESIMKFKKAEVDFLLTTELASRGIDIDHVLYVINYNVPSNVIKYVHRIGRTARI 480
Cdd:PRK11634 260 EVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVERISLVVNYDIPMDSESYVHRIGRTGRA 339
|
410 420
....*....|....*....|....*.
gi 1371547147 481 GKEGIASTLYLQKEKIEVKKIVKGLK 506
Cdd:PRK11634 340 GRAGRALLFVENRERRLLRNIERTMK 365
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
99-287 |
4.14e-41 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 150.08 E-value: 4.14e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 99 LKVLYEQKFSNPTYIQRDVIPLAL-EGKSILANSETGSGKTLAFVLPILERLLQSVnikmRRNNMKGSYNITKALILLPT 177
Cdd:cd17946 2 LRALADLGFSEPTPIQALALPAAIrDGKDVIGAAETGSGKTLAFGIPILERLLSQK----SSNGVGGKQKPLRALILTPT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 178 RELSLQCYDVIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDlLLNSSSDFINYLEIV---VFDEADK 254
Cdd:cd17946 78 RELAVQVKDHLKAIAKYTNIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWE-LIQEGNEHLANLKSLrflVLDEADR 156
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1371547147 255 LLELG-FKE--ECLKILDVC----KFKKQILFFSATLTSD 287
Cdd:cd17946 157 MLEKGhFAEleKILELLNKDragkKRKRQTFVFSATLTLD 196
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
102-313 |
1.38e-40 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 147.25 E-value: 1.38e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 102 LYEQKFSNPTYIQRDVIPLALEG-KSILANSETGSGKTLAFVLPILERLLQSVNIKmrrnnmkgsynitkALILLPTREL 180
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALKRGKGGR--------------VLVLVPTREL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 181 SLQCYDVIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRN-DIFVCTPGRILDLLLNSSSDFINYlEIVVFDEADKLLELG 259
Cdd:smart00487 67 AEQWAEELKKLGPSLGLKVVGLYGGDSKREQLRKLESGKtDILVTTPGRLLDLLENDKLSLSNV-DLVILDEAHRLLDGG 145
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1371547147 260 FKEECLKILDVCKFKKQILFFSATLTSDIKQLANFSLKNPVFIQSGMSFDKNVD 313
Cdd:smart00487 146 FGDQLEKLLKLLPKNVQLLLLSATPPEEIENLLELFLNDPVFIDVGFTPLEPIE 199
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
91-501 |
2.80e-40 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 152.67 E-value: 2.80e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 91 DLYISRPFLKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLlqsvnikmrrnnmKGSYNITK 170
Cdd:PTZ00424 32 ALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLI-------------DYDLNACQ 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 171 ALILLPTRELSLQCYDVIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDlLLNSSSDFINYLEIVVFD 250
Cdd:PTZ00424 99 ALILAPTRELAQQIQKVVLALGDYLKVRCHACVGGTVVRDDINKLKAGVHMVVGTPGRVYD-MIDKRHLRVDDLKLFILD 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 251 EADKLLELGFKeecLKILDVckFKK-----QILFFSATLTSDIKQLANFSLKNPVfiqsgmsfdknvdgkntynayntcn 325
Cdd:PTZ00424 178 EADEMLSRGFK---GQIYDV--FKKlppdvQVALFSATMPNEILELTTKFMRDPK------------------------- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 326 tyndndnnnivvnniisnsflKISNKASFKISENLKQEFVNIIQEKYRKASLLYLCNNIYKNHCIIFFKTKRETHLMYLL 405
Cdd:PTZ00424 228 ---------------------RILVKKDELTLEGIRQFYVAVEKEEWKFDTLCDLYETLTITQAIIYCNTRRKVDYLTKK 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 406 FDLLNLRCAELHGSMSQKKRiESIMK-FKKAEVDFLLTTELASRGIDIDHVLYVINYNVPSNVIKYVHRIGRTARIGKEG 484
Cdd:PTZ00424 287 MHERDFTVSCMHGDMDQKDR-DLIMReFRSGSTRVLITTDLLARGIDVQQVSLVINYDLPASPENYIHRIGRSGRFGRKG 365
|
410
....*....|....*..
gi 1371547147 485 IASTLYLQKEKIEVKKI 501
Cdd:PTZ00424 366 VAINFVTPDDIEQLKEI 382
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
99-302 |
7.61e-40 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 145.93 E-value: 7.61e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 99 LKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLLQSvNIKMRRNNMKGSYnitkALILLPTR 178
Cdd:cd17945 2 LRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRL-PPLDEETKDDGPY----ALILAPTR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 179 ELSLQCYDVIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNS--SSDFINYleiVVFDEADKLL 256
Cdd:cd17945 77 ELAQQIEEETQKFAKPLGIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCLERRllVLNQCTY---VVLDEADRMI 153
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1371547147 257 ELGFKEECLKILD-------------------VCKFK-KQILFFSATLTSDIKQLANFSLKNPVFI 302
Cdd:cd17945 154 DMGFEPQVTKILDampvsnkkpdteeaeklaaSGKHRyRQTMMFTATMPPAVEKIAKGYLRRPVVV 219
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
106-305 |
3.39e-39 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 144.17 E-value: 3.39e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 106 KFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLLQSVNIKMRRNNMKGSyniTKALILLPTRELSLQCY 185
Cdd:cd17967 19 GYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLEDGPPSVGRGRRKAY---PSALILAPTRELAIQIY 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 186 DVIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNS--SSDFINYLeivVFDEADKLLELGFKEE 263
Cdd:cd17967 96 EEARKFSYRSGVRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIERGriSLSSIKFL---VLDEADRMLDMGFEPQ 172
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1371547147 264 CLKILD----VCKFKKQILFFSATLTSDIKQLANFSLKNPVFIQSG 305
Cdd:cd17967 173 IRKIVEhpdmPPKGERQTLMFSATFPREIQRLAADFLKNYIFLTVG 218
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
110-302 |
4.59e-39 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 143.23 E-value: 4.59e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 110 PTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILErllqsvnikmrrnnmkgsynITKALILLPTRELSLQCYDVIR 189
Cdd:cd17938 22 PTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQ--------------------IVVALILEPSRELAEQTYNCIE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 190 SLTKYV---TITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDlLLNSSSDFINYLEIVVFDEADKLLELGFKEECLK 266
Cdd:cd17938 82 NFKKYLdnpKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLED-LIKTGKLDLSSVRFFVLDEADRLLSQGNLETINR 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1371547147 267 IldvckFKK-----------QILFFSATLTS-DIKQLANFSLKNPVFI 302
Cdd:cd17938 161 I-----YNRipkitsdgkrlQVIVCSATLHSfEVKKLADKIMHFPTWV 203
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
99-302 |
5.67e-38 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 140.17 E-value: 5.67e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 99 LKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLLQSvNIKMRRNNMKGSYnitkALILLPTR 178
Cdd:cd17951 2 LKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFALEQ-EKKLPFIKGEGPY----GLIVCPSR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 179 ELSLQCYDVIRSLTKYVTIT-----YSLFC-GGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNS--SSDFINYLeivVFD 250
Cdd:cd17951 77 ELARQTHEVIEYYCKALQEGgypqlRCLLCiGGMSVKEQLEVIRKGVHIVVATPGRLMDMLNKKkiNLDICRYL---CLD 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1371547147 251 EADKLLELGFKEECLKILDVCKFKKQILFFSATLTSDIKQLANFSLKNPVFI 302
Cdd:cd17951 154 EADRMIDMGFEEDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTV 205
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
99-302 |
3.70e-37 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 137.55 E-value: 3.70e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 99 LKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILerllqsVNIKMRRNNMKGSYNItkALILLPTR 178
Cdd:cd17952 2 LNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPML------VHIMDQRELEKGEGPI--AVIVAPTR 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 179 ELSLQCYDVIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNSSSDFiNYLEIVVFDEADKLLEL 258
Cdd:cd17952 74 ELAQQIYLEAKKFGKAYNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKKATNL-QRVTYLVLDEADRMFDM 152
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1371547147 259 GFKEECLKILDVCKFKKQILFFSATLTSDIKQLANFSLKNPVFI 302
Cdd:cd17952 153 GFEYQVRSIVGHVRPDRQTLLFSATFKKKIEQLARDILSDPIRV 196
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
91-302 |
1.27e-36 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 136.30 E-value: 1.27e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 91 DLYISRPFLKVLYEQKFSNPTYI-QRDVIPLaLEGKSILANSETGSGKTLAFVLPILERLLQSVNIkmrrnnmkgsyniT 169
Cdd:cd17939 1 DMGLSEDLLRGIYAYGFEKPSAIqQRAIVPI-IKGRDVIAQAQSGTGKTATFSIGALQRIDTTVRE-------------T 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 170 KALILLPTRELSLQCYDVIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNSSSDfINYLEIVVF 249
Cdd:cd17939 67 QALVLAPTRELAQQIQKVVKALGDYMGVKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRRSLR-TDKIKMFVL 145
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1371547147 250 DEADKLLELGFKEECLKILDVCKFKKQILFFSATLTSDIKQLANFSLKNPVFI 302
Cdd:cd17939 146 DEADEMLSRGFKDQIYDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDPVRI 198
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
110-302 |
2.24e-36 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 135.37 E-value: 2.24e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 110 PTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLLQSVNIKMrrnnmkgsynitkALILLPTRELSLQCYDVIR 189
Cdd:cd17962 13 PTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCLTEHRNPS-------------ALILTPTRELAVQIEDQAK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 190 SLTK-YVTITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNSSSDFINyLEIVVFDEADKLLELGFKEECLKIL 268
Cdd:cd17962 80 ELMKgLPPMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQSSVELDN-IKIVVVDEADTMLKMGFQQQVLDIL 158
|
170 180 190
....*....|....*....|....*....|....
gi 1371547147 269 DVCKFKKQILFFSATLTSDIKQLANFSLKNPVFI 302
Cdd:cd17962 159 ENISHDHQTILVSATIPRGIEQLAGQLLQNPVRI 192
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
99-303 |
1.19e-35 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 133.26 E-value: 1.19e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 99 LKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILerllqsVNIKMRRNNMKGSYNItkALILLPTR 178
Cdd:cd17966 2 MDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAI------VHINAQPPLERGDGPI--VLVLAPTR 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 179 ELSLQCYDVIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNSSSDF--INYLeivVFDEADKLL 256
Cdd:cd17966 74 ELAQQIQQEANKFGGSSRLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGKTNLrrVTYL---VLDEADRML 150
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1371547147 257 ELGFKEECLKILDVCKFKKQILFFSATLTSDIKQLANFSLKNPVFIQ 303
Cdd:cd17966 151 DMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRRLAEDFLKDYIQVN 197
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
98-299 |
1.40e-35 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 134.30 E-value: 1.40e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 98 FLKVLYEQKFSNPTYIQRDVIPLALEG---------KSILANSETGSGKTLAFVLPILERLLQSVNIKMRrnnmkgsyni 168
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAAVIPWLLPSskstppyrpGDLCVSAPTGSGKTLAYVLPIVQALSKRVVPRLR---------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 169 tkALILLPTRELSLQCYDVIRSLTKYVTITYSLFCGGIDIKQQEYEFKK--------RNDIFVCTPGRILDLLLNSSSDF 240
Cdd:cd17956 71 --ALIVVPTKELVQQVYKVFESLCKGTGLKVVSLSGQKSFKKEQKLLLVdtsgrylsRVDILVATPGRLVDHLNSTPGFT 148
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1371547147 241 INYLEIVVFDEADKLLELGFKEECLKILDVCK--------------------FKKQILFFSATLTSDIKQLANFSLKNP 299
Cdd:cd17956 149 LKHLRFLVIDEADRLLNQSFQDWLETVMKALGrptapdlgsfgdanllersvRPLQKLLFSATLTRDPEKLSSLKLHRP 227
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
99-302 |
2.76e-33 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 126.81 E-value: 2.76e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 99 LKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLLQSVNIKMRRNNmkgsyniTKALILLPTR 178
Cdd:cd17958 2 MKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDLQPIPREQRNG-------PGVLVLTPTR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 179 ELSLQCYDVIrslTKYVTITYSLFC--GGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNSSSDF--INYLeivVFDEADK 254
Cdd:cd17958 75 ELALQIEAEC---SKYSYKGLKSVCvyGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMNNVINLksITYL---VLDEADR 148
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1371547147 255 LLELGFKEECLKILDVCKFKKQILFFSATLTSDIKQLANFSLKNPVFI 302
Cdd:cd17958 149 MLDMGFEPQIRKILLDIRPDRQTIMTSATWPDGVRRLAQSYLKDPMIV 196
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
94-302 |
1.86e-32 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 124.22 E-value: 1.86e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 94 ISRPFLKVLYEQKFSNPTYIQRDVIPLALEG--KSILANSETGSGKTLAFVLPILERLlqSVNIKMrrnnmkgsyniTKA 171
Cdd:cd17963 1 LKPELLKGLYAMGFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLAMLSRV--DPTLKS-----------PQA 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 172 LILLPTRELSLQCYDVIRSLTKYVTITYSLFCGGIDIKQQEyefKKRNDIFVCTPGRILDLLLNSSSDfINYLEIVVFDE 251
Cdd:cd17963 68 LCLAPTRELARQIGEVVEKMGKFTGVKVALAVPGNDVPRGK---KITAQIVIGTPGTVLDWLKKRQLD-LKKIKILVLDE 143
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1371547147 252 ADKLLEL-GFKEECLKILDVCKFKKQILFFSATLTSDIKQLANFSLKNPVFI 302
Cdd:cd17963 144 ADVMLDTqGHGDQSIRIKRMLPRNCQILLFSATFPDSVRKFAEKIAPNANTI 195
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
98-303 |
4.11e-31 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 120.45 E-value: 4.11e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 98 FLKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLlqsvNIKMRRnnmkgsyniTKALILLPT 177
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESL----DLERRH---------PQVLILAPT 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 178 RELSLQCYDVIRSLTKYVT-ITYSLFCGGIDIKQQEYEFKKRNdIFVCTPGRILDLL----LNSSSdfinyLEIVVFDEA 252
Cdd:cd17943 68 REIAVQIHDVFKKIGKKLEgLKCEVFIGGTPVKEDKKKLKGCH-IAVGTPGRIKQLIelgaLNVSH-----VRLFVLDEA 141
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1371547147 253 DKLLELGFKEECLKILDVCKFKKQILFFSATLTSDIKQLANFSLKNPVFIQ 303
Cdd:cd17943 142 DKLMEGSFQKDVNWIFSSLPKNKQVIAFSATYPKNLDNLLARYMRKPVLVR 192
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
106-305 |
4.44e-31 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 122.07 E-value: 4.44e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 106 KFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLLQ-----SVNIKMRRNNMKGSYNItkALILLPTREL 180
Cdd:cd18051 40 RYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIYEqgpgeSLPSESGYYGRRKQYPL--ALVLAPTREL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 181 SLQCYDVIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNS--SSDFINYLeivVFDEADKLLEL 258
Cdd:cd18051 118 ASQIYDEARKFAYRSRVRPCVVYGGADIGQQMRDLERGCHLLVATPGRLVDMLERGkiGLDYCKYL---VLDEADRMLDM 194
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1371547147 259 GFKEECLKILDVC----KFKKQILFFSATLTSDIKQLANFSLKNPVFIQSG 305
Cdd:cd18051 195 GFEPQIRRIVEQDtmppTGERQTLMFSATFPKEIQMLARDFLDNYIFLAVG 245
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
94-297 |
6.14e-28 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 113.52 E-value: 6.14e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 94 ISRPFLKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLlqsvnikMRRNNMKGSYNITK--- 170
Cdd:cd18052 50 LCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGM-------MKEGLTASSFSEVQepq 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 171 ALILLPTRELSLQCYDVIRSLTkYVTITYSLFC-GGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNS--SSDFINYLeiv 247
Cdd:cd18052 123 ALIVAPTRELANQIFLEARKFS-YGTCIRPVVVyGGVSVGHQIRQIEKGCHILVATPGRLLDFIGRGkiSLSKLKYL--- 198
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1371547147 248 VFDEADKLLELGFKEECLKILDVC----KFKKQILFFSATLTSDIKQLANFSLK 297
Cdd:cd18052 199 ILDEADRMLDMGFGPEIRKLVSEPgmpsKEDRQTLMFSATFPEEIQRLAAEFLK 252
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
99-305 |
9.13e-28 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 113.18 E-value: 9.13e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 99 LKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILerllqsVNIKMRRNNMKGSYNItkALILLPTR 178
Cdd:cd18050 74 MDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAI------VHINHQPYLERGDGPI--CLVLAPTR 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 179 ELSLQCYDVIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNSSSDF--INYLeivVFDEADKLL 256
Cdd:cd18050 146 ELAQQVQQVADDYGKSSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLrrCTYL---VLDEADRML 222
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1371547147 257 ELGFKEECLKILDVCKFKKQILFFSATLTSDIKQLANFSLKNPVFIQSG 305
Cdd:cd18050 223 DMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYVQINIG 271
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
99-305 |
1.96e-27 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 111.25 E-value: 1.96e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 99 LKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILerllqsVNIKMRRNNMKGSYNItkALILLPTR 178
Cdd:cd18049 36 MDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAI------VHINHQPFLERGDGPI--CLVLAPTR 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 179 ELSLQCYDVIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNSSSDfINYLEIVVFDEADKLLEL 258
Cdd:cd18049 108 ELAQQVQQVAAEYGRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTN-LRRCTYLVLDEADRMLDM 186
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1371547147 259 GFKEECLKILDVCKFKKQILFFSATLTSDIKQLANFSLKNPVFIQSG 305
Cdd:cd18049 187 GFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIG 233
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
98-291 |
4.58e-27 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 110.15 E-value: 4.58e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 98 FLKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLLQsvnikmRRNNMKGSYNITKALILLPT 177
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLR------YKLLAEGPFNAPRGLVITPS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 178 RELSLQCYDVIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDLLlnsSSDFI--NYLEIVVFDEADKL 255
Cdd:cd17948 75 RELAEQIGSVAQSLTEGLGLKVKVITGGRTKRQIRNPHFEEVDILVATPGALSKLL---TSRIYslEQLRHLVLDEADTL 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1371547147 256 LELGFKEECLKILDVCKFKK-------------QILFFSATLTSDIKQL 291
Cdd:cd17948 152 LDDSFNEKLSHFLRRFPLASrrsentdgldpgtQLVLVSATMPSGVGEV 200
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
377-481 |
8.83e-27 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 104.99 E-value: 8.83e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 377 LLYLCNNIYKNHCIIFFKTKRETHLMYLLFdLLNLRCAELHGSMSQKKRIESIMKFKKAEVDFLLTTELASRGIDIDHVL 456
Cdd:pfam00271 6 LLELLKKERGGKVLIFSQTKKTLEAELLLE-KEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPDVD 84
|
90 100
....*....|....*....|....*
gi 1371547147 457 YVINYNVPSNVIKYVHRIGRTARIG 481
Cdd:pfam00271 85 LVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
91-302 |
9.44e-27 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 108.30 E-value: 9.44e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 91 DLYISRPFLKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLLQSVNIkmrrnnmkgsyniTK 170
Cdd:cd18046 3 DMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQIDTSLKA-------------TQ 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 171 ALILLPTRELSLQCYDVIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDlLLNSSSDFINYLEIVVFD 250
Cdd:cd18046 70 ALVLAPTRELAQQIQKVVMALGDYMGIKCHACIGGTSVRDDAQKLQAGPHIVVGTPGRVFD-MINRRYLRTDYIKMFVLD 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1371547147 251 EADKLLELGFKEECLKILDVCKFKKQILFFSATLTSDIKQLANFSLKNPVFI 302
Cdd:cd18046 149 EADEMLSRGFKDQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDPIRI 200
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
91-302 |
2.59e-25 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 104.35 E-value: 2.59e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 91 DLYISRPFLKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLlqsvnikmrrnnmKGSYNITK 170
Cdd:cd17950 6 DFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQL-------------EPVDGQVS 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 171 ALILLPTRELSLQCYDVIRSLTKYV-TITYSLFCGGIDIKQQEYEFKKRN-DIFVCTPGRILDLLLNSSSDfINYLEIVV 248
Cdd:cd17950 73 VLVICHTRELAFQISNEYERFSKYMpNVKTAVFFGGVPIKKDIEVLKNKCpHIVVGTPGRILALVREKKLK-LSHVKHFV 151
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1371547147 249 FDEADKLLE-LGFKEECLKILDVCKFKKQILFFSATLTSDIKQLANFSLKNPVFI 302
Cdd:cd17950 152 LDECDKMLEqLDMRRDVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPLEI 206
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
113-283 |
4.69e-24 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 100.31 E-value: 4.69e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 113 IQRDVIPLALEGKSILANSETGSGKTLAFVLPILERlLQSVNIKMRRNNMKgsynitKALILLPTRELSLQCYDVIRSLT 192
Cdd:cd17944 16 IQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEK-LQEDQQPRKRGRAP------KVLVLAPTRELANQVTKDFKDIT 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 193 KYVTItySLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNSSSDfINYLEIVVFDEADKLLELGFKEECLKILDVcK 272
Cdd:cd17944 89 RKLSV--ACFYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLD-LTKLKHVVLDEVDQMLDMGFAEQVEEILSV-S 164
|
170
....*....|....*..
gi 1371547147 273 FKK------QILFFSAT 283
Cdd:cd17944 165 YKKdsednpQTLLFSAT 181
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
99-302 |
4.72e-24 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 100.23 E-value: 4.72e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 99 LKVLYEQKFSNPTYIQ-RDVIPLaLEGKSILANSETGSGKTLAFVLPILerllQSVNIKMRRnnmkgsyniTKALILLPT 177
Cdd:cd18045 11 LRGIYAYGFEKPSAIQqRAIKPI-IKGRDVIAQSQSGTGKTATFSISVL----QCLDIQVRE---------TQALILSPT 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 178 RELSLQCYDVIRSLTKYVTITYSLFCGGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNSSSDFiNYLEIVVFDEADKLLE 257
Cdd:cd18045 77 RELAVQIQKVLLALGDYMNVQCHACIGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRRSLRT-RHIKMLVLDEADEMLN 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1371547147 258 LGFKEEclkILDVCKF---KKQILFFSATLTSDIKQLANFSLKNPVFI 302
Cdd:cd18045 156 KGFKEQ---IYDVYRYlppATQVVLVSATLPQDILEMTNKFMTDPIRI 200
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
402-481 |
2.95e-23 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 93.82 E-value: 2.95e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 402 MYLLFDLLNLRCAELHGSMSQKKRIESIMKFKKAEVDFLLTTELASRGIDIDHVLYVINYNVPSNVIKYVHRIGRTARIG 481
Cdd:smart00490 3 LAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
132-284 |
7.28e-19 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 86.66 E-value: 7.28e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 132 ETGSGKTLAFVLPILERL----LQSVNIKMRRNNMKGSYNITKALILLPTRELSLQCYDVIRSLTKYVTI---TYSLFCG 204
Cdd:cd17965 69 ETGSGKTLAYLAPLLDYLkrqeQEPFEEAEEEYESAKDTGRPRSVILVPTHELVEQVYSVLKKLSHTVKLgikTFSSGFG 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 205 GIDIKQQEYeFKKRNDIFVCTPGRILDlLLNSSSDFINYLEIVVFDEADKLLELGFKEECLKILDVCKFKKQILFFSATL 284
Cdd:cd17965 149 PSYQRLQLA-FKGRIDILVTTPGKLAS-LAKSRPKILSRVTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSATI 226
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
124-283 |
5.42e-18 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 81.30 E-value: 5.42e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 124 GKSILANSETGSGKTLAFVLPILERLLQsvnikmrrnnmkgsyNITKALILLPTRELSLQCYDVIRSLTKYVtITYSLFC 203
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLLLLK---------------KGKKVLVLVPTKALALQTAERLRELFGPG-IRVAVLV 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 204 GGIDIKQQEYEFKKRNDIFVCTPGRILDLLLNSSSDFINYLEIVVFDEADKLLELGFKEECLKILDVCKFKK--QILFFS 281
Cdd:cd00046 65 GGSSAEEREKNKLGDADIIIATPDMLLNLLLREDRLFLKDLKLIIVDEAHALLIDSRGALILDLAVRKAGLKnaQVILLS 144
|
..
gi 1371547147 282 AT 283
Cdd:cd00046 145 AT 146
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
89-303 |
5.44e-17 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 80.15 E-value: 5.44e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 89 WSDLYISRPFLKVLYEQKFSNPTYIQRDVIPLALEG--KSILANSETGSGKTLAFVLPILerllqsvnikmrrNNMKGSY 166
Cdd:cd18047 3 FEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAML-------------SQVEPAN 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 167 NITKALILLPTRELSLQCYDVIRSLTKY---VTITYSlfcggIDIKQQEYEFKKRNDIFVCTPGRILDLLLNSSSDFINY 243
Cdd:cd18047 70 KYPQCLCLSPTYELALQTGKVIEQMGKFypeLKLAYA-----VRGNKLERGQKISEQIVIGTPGTVLDWCSKLKFIDPKK 144
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1371547147 244 LEIVVFDEADKLLEL-GFKEECLKILDVCKFKKQILFFSATLTSDIKQLANFSLKNPVFIQ 303
Cdd:cd18047 145 IKVFVLDEADVMIATqGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIK 205
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
89-303 |
8.47e-17 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 80.07 E-value: 8.47e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 89 WSDLYISRPFLKVLYEQKFSNPTYIQRDVIPLALEG--KSILANSETGSGKTLAFVLPILERLlqsvnikmrrnNMKGSY 166
Cdd:cd18048 20 FEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRV-----------DALKLY 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 167 niTKALILLPTRELSLQCYDVIRSLTKY---VTITYSLFCG----GIDIKQQeyefkkrndIFVCTPGRILDLLLNSSSD 239
Cdd:cd18048 89 --PQCLCLSPTFELALQTGKVVEEMGKFcvgIQVIYAIRGNrpgkGTDIEAQ---------IVIGTPGTVLDWCFKLRLI 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1371547147 240 FINYLEIVVFDEADKLLEL-GFKEECLKILDVCKFKKQILFFSATLTSDIKQLANFSLKNPVFIQ 303
Cdd:cd18048 158 DVTNISVFVLDEADVMINVqGHSDHSVRVKRSMPKECQMLLFSATFEDSVWAFAERIVPDPNIIK 222
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
111-284 |
3.05e-14 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 71.52 E-value: 3.05e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 111 TYIQRDVI-PLALEGKSILANSETGSGKTLAFVLPILERLLQSvnikmrrnnmkgsynITKALILLPTRELSLQCYDVIR 189
Cdd:cd17921 3 NPIQREALrALYLSGDSVLVSAPTSSGKTLIAELAILRALATS---------------GGKAVYIAPTRALVNQKEADLR 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 190 SLTKYVTITYSLFCGGIDIKQQEyefKKRNDIFVCTPGRILDLLLNSSSDFINYLEIVVFDEADKL--------LELGfk 261
Cdd:cd17921 68 ERFGPLGKNVGLLTGDPSVNKLL---LAEADILVATPEKLDLLLRNGGERLIQDVRLVVVDEAHLIgdgergvvLELL-- 142
|
170 180
....*....|....*....|...
gi 1371547147 262 eeCLKILDVCKfKKQILFFSATL 284
Cdd:cd17921 143 --LSRLLRINK-NARFVGLSATL 162
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
114-252 |
1.72e-13 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 69.15 E-value: 1.72e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 114 QRDVIPLALEGKSILANSETGSGKTLAFVLPILERLLQSVNikmrrnnmkgsyniTKALILLPTRELSlqcYDVIRSLTK 193
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEALLRDPG--------------SRALYLYPTKALA---QDQLRSLRE 67
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 194 YVT-----ITYSLFCGgiDIKQQEYEFKKRN--DIFVCTPgRILDLLL----NSSSDFINYLEIVVFDEA 252
Cdd:cd17923 68 LLEqlglgIRVATYDG--DTPREERRAIIRNppRILLTNP-DMLHYALlphhDRWARFLRNLRYVVLDEA 134
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
114-293 |
7.61e-13 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 71.46 E-value: 7.61e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 114 QRDVIPLAL-EGKSILANSETGSGKTLAFVLPILERLLQSvnikmrrnnmkgsyniTKALILLPTRELslqCYDVIRSLT 192
Cdd:COG1204 27 QAEALEAGLlEGKNLVVSAPTASGKTLIAELAILKALLNG----------------GKALYIVPLRAL---ASEKYREFK 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 193 KY-------VTITYslfcGGIDIkqqEYEFKKRNDIFVCTPGRiLDLLLNSSSDFINYLEIVVFDEADKL--LELGFKEE 263
Cdd:COG1204 88 RDfeelgikVGVST----GDYDS---DDEWLGRYDILVATPEK-LDSLLRNGPSWLRDVDLVVVDEAHLIddESRGPTLE 159
|
170 180 190
....*....|....*....|....*....|..
gi 1371547147 264 CL--KILDVCKfKKQILFFSATLtSDIKQLAN 293
Cdd:COG1204 160 VLlaRLRRLNP-EAQIVALSATI-GNAEEIAE 189
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
420-566 |
5.72e-11 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 65.91 E-value: 5.72e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 420 MSQKKRIESIMKFKKAEVDFLLTTELASRGIDIDHVLYVINY-NVPSNvIKYVHRIGRTARIGK--------EGIASTLY 490
Cdd:COG1111 395 LTQKEQIEILERFRAGEFNVLVATSVAEEGLDIPEVDLVIFYePVPSE-IRSIQRKGRTGRKREgrvvvliaKGTRDEAY 473
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 491 ----LQKEKiEVKKIVKGLKksknlKILKRTIAENNvlvwykiIKENKQKLNDIIQQEKIDKEIEMSNKSIDKIKNMITF 566
Cdd:COG1111 474 ywssRRKEK-KMKSILKKLK-----KLLDKQEKEKL-------KESAQATLDEFESIKELAEDEINEKDLDEIESSENGA 540
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
420-551 |
4.09e-10 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 62.97 E-value: 4.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 420 MSQKKRIESIMKFKKAEVDFLLTTELASRGIDIDHVLYVINYN-VPSNvIKYVHRIGRTARiGKEGIASTLY-------- 490
Cdd:PRK13766 407 MSQKEQIEILDKFRAGEFNVLVSTSVAEEGLDIPSVDLVIFYEpVPSE-IRSIQRKGRTGR-QEEGRVVVLIakgtrdea 484
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1371547147 491 -----LQKEKiEVKKIVKGLKksknlKILKRTIAENNVLVWYKIIKENKQKLNDIIQQEKIDKEIE 551
Cdd:PRK13766 485 yywssRRKEK-KMKEELKNLK-----GILNKKLQELDEEQKGEEEEKDEQLSLDDFVKSKGKEEEE 544
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
389-479 |
3.56e-09 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 55.68 E-value: 3.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 389 CIIFFKTKRETHLMYLLF-----DLLNLRCAELHGS----------MSQKKRIESIMKFKKAEVDFLLTTELASRGIDID 453
Cdd:cd18802 28 GIIFVERRATAVVLSRLLkehpsTLAFIRCGFLIGRgnssqrkrslMTQRKQKETLDKFRDGELNLLIATSVLEEGIDVP 107
|
90 100
....*....|....*....|....*.
gi 1371547147 454 HVLYVINYNVPSNVIKYVHRIGRtAR 479
Cdd:cd18802 108 ACNLVIRFDLPKTLRSYIQSRGR-AR 132
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
133-490 |
7.75e-09 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 58.88 E-value: 7.75e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 133 TGSGKTLAFVLpILERLLqsvnikmrrnnmkgsyNITKALILLPTRELSLQCYDVIRSLTKyvtitysLFCGGIDIKQQE 212
Cdd:COG1061 109 TGTGKTVLALA-LAAELL----------------RGKRVLVLVPRRELLEQWAEELRRFLG-------DPLAGGGKKDSD 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 213 YefkkrnDIFVCTpgriLDLLLNSSS--DFINYLEIVVFDEADKLLELGFKeeclKILDVCKFKKqILFFSATLT-SDIK 289
Cdd:COG1061 165 A------PITVAT----YQSLARRAHldELGDRFGLVIIDEAHHAGAPSYR----RILEAFPAAY-RLGLTATPFrSDGR 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 290 QLANFSLKNPVF-------IQSGM-----SFDKNVDGKNTYNAYNtcntyndndnnnivvnniisnsflkisnkasfKIS 357
Cdd:COG1061 230 EILLFLFDGIVYeyslkeaIEDGYlappeYYGIRVDLTDERAEYD--------------------------------ALS 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 358 ENLKQEFVNIIQEKYRKASLLyLCNNIYKNHCIIFFKTKRETHLMYLLFDLLNLRCAELHGSMSQKKRIESIMKFKKAEV 437
Cdd:COG1061 278 ERLREALAADAERKDKILREL-LREHPDDRKTLVFCSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGEL 356
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1371547147 438 DFLLTTELASRGIDIDHVLYVInYNVP-SNVIKYVHRIGRTARIGKEGIASTLY 490
Cdd:COG1061 357 RILVTVDVLNEGVDVPRLDVAI-LLRPtGSPREFIQRLGRGLRPAPGKEDALVY 409
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
133-252 |
1.08e-08 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 55.74 E-value: 1.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 133 TGSGKTLAFVLPILErllqsvnikMRRNNMKGSYNITKALILLPTRELSLQCYDVIRSLTKYVTITYslfCGGIDIKQQE 212
Cdd:cd18034 25 TGSGKTLIAVMLIKE---------MGELNRKEKNPKKRAVFLVPTVPLVAQQAEAIRSHTDLKVGEY---SGEMGVDKWT 92
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1371547147 213 ----YEFKKRNDIFVCTPGRILDLLLNSssdFI--NYLEIVVFDEA 252
Cdd:cd18034 93 kerwKEELEKYDVLVMTAQILLDALRHG---FLslSDINLLIFDEC 135
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
104-151 |
1.40e-08 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 58.19 E-value: 1.40e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 1371547147 104 EQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLLQ 151
Cdd:COG1201 19 AARFGAPTPPQREAWPAIAAGESTLLIAPTGSGKTLAAFLPALDELAR 66
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
420-479 |
3.93e-08 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 52.74 E-value: 3.93e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 420 MSQKKRIESIMKFKKAEVDFLLTTELASRGIDIDHVLYVINYNVPSNVIKYVHRIGRTAR 479
Cdd:cd18801 74 MSQKEQKEVIEQFRKGGYNVLVATSIGEEGLDIGEVDLIICYDASPSPIRMIQRMGRTGR 133
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
114-252 |
6.51e-08 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 56.00 E-value: 6.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 114 QRDVIPLALEGKSILANSETGSGKTLAFVLPILERLLQSVNikmrrnnmkgsyniTKALILLPTRELSlqcYDVIRSLTK 193
Cdd:COG1205 61 QAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEALLEDPG--------------ATALYLYPTKALA---RDQLRRLRE 123
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1371547147 194 YVT-----ITYSLFCGgiDIKQQE-YEFKKRNDIFVCTPgrilD-----LLLNSS--SDFINYLEIVVFDEA 252
Cdd:COG1205 124 LAEalglgVRVATYDG--DTPPEErRWIREHPDIVLTNP----DmlhygLLPHHTrwARFFRNLRYVVIDEA 189
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
389-479 |
2.67e-07 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 50.73 E-value: 2.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 389 CIIFFKTKRETHLMYllfDLLNLRCAEL---------HGSMS--QKKRIESimKFKKAEVDFLLTT---ELasrGIDIDH 454
Cdd:cd18796 41 TLVFTNTRSQAERLA---QRLRELCPDRvppdfialhHGSLSreLREEVEA--ALKRGDLKVVVATsslEL---GIDIGD 112
|
90 100
....*....|....*....|....*
gi 1371547147 455 VLYVINYNVPSNVIKYVHRIGRTAR 479
Cdd:cd18796 113 VDLVIQIGSPKSVARLLQRLGRSGH 137
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
424-484 |
4.03e-07 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 48.08 E-value: 4.03e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1371547147 424 KRIESIMKFkkaevdfLLTTELASRGIDIDHVLYVINYNVPSNVIKYVHRIGRTARIGKEG 484
Cdd:cd18785 17 EEIASSLEI-------LVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDE 70
|
|
| DEXHc_RIG-I |
cd17927 |
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ... |
121-252 |
1.20e-05 |
|
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350685 [Multi-domain] Cd Length: 201 Bit Score: 46.66 E-value: 1.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 121 ALEGKSILANSETGSGKTLAFVLpILERLLQsvniKMRRNNMKgsynitKALILLPTRELSLQCYDVIRSLT---KYVTI 197
Cdd:cd17927 14 ALKGKNTIICLPTGSGKTFVAVL-ICEHHLK----KFPAGRKG------KVVFLANKVPLVEQQKEVFRKHFerpGYKVT 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1371547147 198 TYSlfcGGIDIKQQEYEFKKRNDIFVCTPGRILDLLLN----SSSDFinylEIVVFDEA 252
Cdd:cd17927 83 GLS---GDTSENVSVEQIVESSDVIIVTPQILVNDLKSgtivSLSDF----SLLVFDEC 134
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
96-150 |
1.49e-05 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 48.34 E-value: 1.49e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1371547147 96 RPFLKVLYEQKFSNPTYIQRDVIPLALEGKSILANSETGSGKTLAFVLPILERLL 150
Cdd:PRK13767 19 RPYVREWFKEKFGTFTPPQRYAIPLIHEGKNVLISSPTGSGKTLAAFLAIIDELF 73
|
|
| DEXHc_Hef |
cd18035 |
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs ... |
110-252 |
1.40e-04 |
|
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. All archaea encode a protein of the XPF/MUS81/FANCM family of endonucleases. It exists in two forms: a long form, referred as Hef which consists of an N-terminal helicase fused to a C-terminal nuclease and is specific to euryarchaea and a short form, referred as XPF which lacks the helicase domain and is specific to crenarchaea and thaumarchaea. Hef has the unique feature of having both active helicase and nuclease domains. This domain configuration is highly similar with the human FANCM, a possible ortholog of archaeal Hef proteins. Hef is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350793 [Multi-domain] Cd Length: 181 Bit Score: 43.27 E-value: 1.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 110 PTYIQRDVIPLALEGKSILANSeTGSGKTLAFVLPILERLLQsvnikmrrnnmKGSynitKALILLPTRELSLQCYDVIR 189
Cdd:cd18035 3 RRLYQVLIAAVALNGNTLIVLP-TGLGKTIIAILVAADRLTK-----------KGG----KVLILAPSRPLVEQHAENLK 66
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1371547147 190 SL----TKYVTITyslfcGGIDIKQQEyEFKKRNDIFVCTPGRILDLLLNSSSDfINYLEIVVFDEA 252
Cdd:cd18035 67 RVlnipDKITSLT-----GEVKPEERA-ERWDASKIIVATPQVIENDLLAGRIT-LDDVSLLIFDEA 126
|
|
| DEXHc_cas3 |
cd17930 |
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase ... |
127-252 |
2.65e-04 |
|
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350688 [Multi-domain] Cd Length: 186 Bit Score: 42.66 E-value: 2.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 127 ILANSETGSGKTLAFVLPILErllQSVNIKMRRnnmkgsynitkaLIL-LPTRELSLQCYDVIRSLTKYVTITYSL---- 201
Cdd:cd17930 4 VILEAPTGSGKTEAALLWALK---LAARGGKRR------------IIYaLPTRATINQMYERIREILGRLDDEDKVlllh 68
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1371547147 202 -------------FCGGIDIKQQEYEFKKRN---DIFVCTPGRILDLLLNSSSDFINYLEI----VVFDEA 252
Cdd:cd17930 69 skaalellesdeePDDDPVEAVDWALLLKRSwlaPIVVTTIDQLLESLLKYKHFERRLHGLansvVVLDEV 139
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
389-502 |
4.50e-04 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 40.92 E-value: 4.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 389 CIIFFKTKRETHLMYLLFDLLNLRCAELHGSMSQKKRIESIMKFKK--AEVDFLLTTELASRGIDI---DHvlyVINYNV 463
Cdd:cd18793 30 VLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEdpDIRVFLLSTKAGGVGLNLtaaNR---VILYDP 106
|
90 100 110
....*....|....*....|....*....|....*....
gi 1371547147 464 PSNVIKYVHRIGRTARIGkegiastlylQKEKIEVKKIV 502
Cdd:cd18793 107 WWNPAVEEQAIDRAHRIG----------QKKPVVVYRLI 135
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
389-502 |
8.49e-04 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 42.52 E-value: 8.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 389 CIIFfkTKRETHLMYL--LFDLLNLRCAELHGSMSQKKRIESIMKFK-KAEVD-FLLTTELASRGIDI---DHvlyVINY 461
Cdd:COG0553 552 VLVF--SQFTDTLDLLeeRLEERGIEYAYLHGGTSAEERDELVDRFQeGPEAPvFLISLKAGGEGLNLtaaDH---VIHY 626
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1371547147 462 NVPSNVIKYVHRIGRTARIGkegiastlylQKEKIEVKKIV 502
Cdd:COG0553 627 DLWWNPAVEEQAIDRAHRIG----------QTRDVQVYKLV 657
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
124-251 |
1.39e-03 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 39.87 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 124 GKSILANSETGSGKTLAFVLPILERLLqsvnikmrRNNMKGsyniTKALILLPTRELSlqcYDVIRSLTKYVT-----IT 198
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSLA--------DEPEKG----VQVLYISPLKALI---NDQERRLEEPLDeidleIP 65
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1371547147 199 YSLFCGGIDIKQQEYEFKKRNDIFVCTPgRILDLLLNS---SSDFINyLEIVVFDE 251
Cdd:cd17922 66 VAVRHGDTSQSEKAKQLKNPPGILITTP-ESLELLLVNkklRELFAG-LRYVVVDE 119
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
370-490 |
1.80e-03 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 39.11 E-value: 1.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 370 EKYRKASLLYLCNNIYKNHC-----IIFFKTKRETHLMYLLFDLLNLRCAELHGSMSQKKRIESIMKFKKAEVDFLLTTE 444
Cdd:cd18794 9 RPKDKKDEKLDLLKRIKVEHlggsgIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVATV 88
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1371547147 445 LASRGIDIDHVLYVINYNVPSNVIKYVHRIGRTARIGKEGIASTLY 490
Cdd:cd18794 89 AFGMGIDKPDVRFVIHYSLPKSMESYYQESGRAGRDGLPSECILFY 134
|
|
| DEXHc_POLQ-like |
cd18026 |
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in ... |
119-294 |
3.12e-03 |
|
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in the repair of genomic double-strand breaks (DSBs). POLQ contains an N-terminal type II DEAD box helicase domain which contains the ATP-binding region.
Pssm-ID: 350784 [Multi-domain] Cd Length: 202 Bit Score: 39.51 E-value: 3.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 119 PLALEGKSILANSETGSGKTL-AFVLpILERLLQsvnikMRRnnmkgsynitKALILLPtrelslqcydvirsltkYVTI 197
Cdd:cd18026 28 PGLLEGRNLVYSLPTSGGKTLvAEIL-MLKRLLE-----RRK----------KALFVLP-----------------YVSI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 198 ------TYSLFCGGIDIKQQEY---------EFKKRNDIFVCTPGRiLDLLLNS--SSDFINYLEIVVFDEAD------- 253
Cdd:cd18026 75 vqekvdALSPLFEELGFRVEGYagnkgrsppKRRKSLSVAVCTIEK-ANSLVNSliEEGRLDELGLVVVDELHmlgdghr 153
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1371547147 254 -KLLELGFKeeclKILDVCKFKKQILFFSATLtSDIKQLANF 294
Cdd:cd18026 154 gALLELLLT----KLLYAAQKNIQIVGMSATL-PNLEELASW 190
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
125-283 |
4.13e-03 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 38.42 E-value: 4.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 125 KSILANSETGSGKTL-AFVlpILERLLQSVNIKmrrnnmkgsynitKALILLPTRELSLQCYDvirSLTKYVTITYSLfc 203
Cdd:pfam04851 24 KRGLIVMATGSGKTLtAAK--LIARLFKKGPIK-------------KVLFLVPRKDLLEQALE---EFKKFLPNYVEI-- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 204 gGIDIKQQEYEFKKRN-DIFVCTPGRIL-DLLLNSSSDFINYLEIVVFDEADKLLELGFKeeclKILDvcKFKKQILF-F 280
Cdd:pfam04851 84 -GEIISGDKKDESVDDnKIVVTTIQSLYkALELASLELLPDFFDVIIIDEAHRSGASSYR----NILE--YFKPAFLLgL 156
|
...
gi 1371547147 281 SAT 283
Cdd:pfam04851 157 TAT 159
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
122-251 |
5.25e-03 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 38.47 E-value: 5.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 122 LEGKSILANSETGSGKTLAFVLPILERLLqsvnikmrrnnmKGSynitKALILLPTRELSLQCYDVIRSLTKY---VTIT 198
Cdd:cd18028 15 LKGENLLISIPTASGKTLIAEMAMVNTLL------------EGG----KALYLVPLRALASEKYEEFKKLEEIglkVGIS 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1371547147 199 yslfCGGIDIKQqeyEFKKRNDIFVCTPGRiLDLLLNSSSDFINYLEIVVFDE 251
Cdd:cd18028 79 ----TGDYDEDD---EWLGDYDIIVATYEK-FDSLLRHSPSWLRDVGVVVVDE 123
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
111-186 |
6.80e-03 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 38.49 E-value: 6.80e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1371547147 111 TYIQRDVIPLALEG-KSILANSETGSGKTLAFVLPILeRLLQSVNIKMRRNnmkgsyniTKALILLPTRELSLQCYD 186
Cdd:cd18023 3 NRIQSEVFPDLLYSdKNFVVSAPTGSGKTVLFELAIL-RLLKERNPLPWGN--------RKVVYIAPIKALCSEKYD 70
|
|
| DEXHc_RLR |
cd18036 |
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense ... |
114-251 |
7.06e-03 |
|
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprise RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). RIG-I-like receptors (RLRs) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350794 [Multi-domain] Cd Length: 204 Bit Score: 38.61 E-value: 7.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371547147 114 QRDVIPLALEGKSILANSETGSGKTLAFVLPILERLlqsvniKMRRNNMKGSynitKALILLPTRELSLQCYDVirsLTK 193
Cdd:cd18036 7 QLELVLPALRGKNTIICAPTGSGKTRVAVYICRHHL------EKRRSAGEKG----RVVVLVNKVPLVEQQLEK---FFK 73
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1371547147 194 YVTITYSL--FCGGIDIKQQEYEFKKRNDIFVCTPGRILDLLLN-------SSSDFinylEIVVFDE 251
Cdd:cd18036 74 YFRKGYKVtgLSGDSSHKVSFGQIVKASDVIICTPQILINNLLSgreeervYLSDF----SLLIFDE 136
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
417-476 |
9.26e-03 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 39.48 E-value: 9.26e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1371547147 417 HGSMSQKKRIESIMKFKKAEVDFLLTT---ELasrGIDIDHVLYVINYNVPSNVIKYVHRIGR 476
Cdd:PRK13767 321 HSSLSREVRLEVEEKLKRGELKVVVSStslEL---GIDIGYIDLVVLLGSPKSVSRLLQRIGR 380
|
|
| |
