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Conserved domains on  [gi|124505713|ref|XP_001350970|]
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actin-related protein [Plasmodium falciparum 3D7]

Protein Classification

type III pantothenate kinase; acetate/propionate family kinase( domain architecture ID 10794401)

type III pantothenate kinase catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis| acetate/propionate family kinase

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PTZ00466 PTZ00466
actin-like protein; Provisional
1-380 0e+00

actin-like protein; Provisional


:

Pssm-ID: 240426 [Multi-domain]  Cd Length: 380  Bit Score: 828.43  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713   1 MNNDYVNNIYPNQPVIIDNGTGYIKSGFAGEDIPSLVFPSYVGRPKYKRVMAGAVEGNIFVGNKAEEYRGLLKVTYPINH 80
Cdd:PTZ00466   1 KMNEYAKQLYSNQPIIIDNGTGYIKAGFAGEDVPNLVFPSYVGRPKYKRVMAGAVEGNIFVGNKAEEYRGLLKVTYPINH 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  81 GIIQNWNDMENIWIHVYNSLKINSDEHPILLTEAPLNPQKNKEKIAEVFFETFNVPALFISMQAILSLYSCGKTNGTVLD 160
Cdd:PTZ00466  81 GIIENWNDMENIWIHVYNSMKINSEEHPVLLTEAPLNPQKNKEKIAEVFFETFNVPALFISIQAILSLYSCGKTNGTVLD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 161 CGDGVCHCVSIYEGYNITNTITRTDVAGRDITNYLSFLLRKNGHLFNTSSEMEVVKNMKENCCYVSFNMNKEKNSSEKAV 240
Cdd:PTZ00466 161 CGDGVCHCVSIYEGYSITNTITRTDVAGRDITTYLGYLLRKNGHLFNTSAEMEVVKNMKENCCYVSFNMNKEKNSSEKAL 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 241 TTLPYILPDGSQILIGSERYRAPEVLFNPSILGLEYLGLSELIVTSITRADMDLRKTLYSHIVLSGGTTLFQGFGDRLLN 320
Cdd:PTZ00466 241 TTLPYILPDGSQILIGSERYRAPEVLFNPSILGLEYLGLSELIVTSITRADMDLRRTLYSHIVLSGGTTMFHGFGDRLLN 320
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 321 EIRKFAPKDITIRISAPPERKFSTFIGGSILASLATFKKIWISKQEFDEYGSVILHKKSF 380
Cdd:PTZ00466 321 EIRKFAPKDITIRISAPPERKFSTFIGGSILASLATFKKIWISKQEFDEYGSVILHRKTF 380
 
Name Accession Description Interval E-value
PTZ00466 PTZ00466
actin-like protein; Provisional
1-380 0e+00

actin-like protein; Provisional


Pssm-ID: 240426 [Multi-domain]  Cd Length: 380  Bit Score: 828.43  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713   1 MNNDYVNNIYPNQPVIIDNGTGYIKSGFAGEDIPSLVFPSYVGRPKYKRVMAGAVEGNIFVGNKAEEYRGLLKVTYPINH 80
Cdd:PTZ00466   1 KMNEYAKQLYSNQPIIIDNGTGYIKAGFAGEDVPNLVFPSYVGRPKYKRVMAGAVEGNIFVGNKAEEYRGLLKVTYPINH 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  81 GIIQNWNDMENIWIHVYNSLKINSDEHPILLTEAPLNPQKNKEKIAEVFFETFNVPALFISMQAILSLYSCGKTNGTVLD 160
Cdd:PTZ00466  81 GIIENWNDMENIWIHVYNSMKINSEEHPVLLTEAPLNPQKNKEKIAEVFFETFNVPALFISIQAILSLYSCGKTNGTVLD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 161 CGDGVCHCVSIYEGYNITNTITRTDVAGRDITNYLSFLLRKNGHLFNTSSEMEVVKNMKENCCYVSFNMNKEKNSSEKAV 240
Cdd:PTZ00466 161 CGDGVCHCVSIYEGYSITNTITRTDVAGRDITTYLGYLLRKNGHLFNTSAEMEVVKNMKENCCYVSFNMNKEKNSSEKAL 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 241 TTLPYILPDGSQILIGSERYRAPEVLFNPSILGLEYLGLSELIVTSITRADMDLRKTLYSHIVLSGGTTLFQGFGDRLLN 320
Cdd:PTZ00466 241 TTLPYILPDGSQILIGSERYRAPEVLFNPSILGLEYLGLSELIVTSITRADMDLRRTLYSHIVLSGGTTMFHGFGDRLLN 320
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 321 EIRKFAPKDITIRISAPPERKFSTFIGGSILASLATFKKIWISKQEFDEYGSVILHKKSF 380
Cdd:PTZ00466 321 EIRKFAPKDITIRISAPPERKFSTFIGGSILASLATFKKIWISKQEFDEYGSVILHRKTF 380
ASKHA_NBD_Arp1 cd10216
nucleotide-binding domain (NBD) of actin-related protein 1 (Arp1) and similar proteins; Arp1, ...
12-379 0e+00

nucleotide-binding domain (NBD) of actin-related protein 1 (Arp1) and similar proteins; Arp1, also called centractin, actin-like protein, alpha-centractin, actin-RPV, or centrosome-associated actin homolog, may be a component of a multi-subunit centrosomal complex involved in microtubule-based vesicle motility. In yeast, actin-related protein is essential for viability and is associated with the centrosome. In vertebrates, Arp1 is a core component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding. The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint. ARP1 forms the backbone filament of the dynactin rod structure and serves as the scaffold for the remaining subunits. It is required for proper orientation of the mitotic spindle. Arp1 is the only actin-related protein known to form actin-like filaments. Human Arp1/centractin is encoded by the ACTR1A gene.


Pssm-ID: 466820 [Multi-domain]  Cd Length: 370  Bit Score: 723.95  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  12 NQPVIIDNGTGYIKSGFAGEDIPSLVFPSYVGRPKYKRVMAGAVEGNIFVGNKAEEYRGLLKVTYPINHGIIQNWNDMEN 91
Cdd:cd10216    1 NQPVVIDNGSGVIKAGFAGDDIPKVVFPSYVGRPKHVRVMAGALEGDVFVGPKAEEHRGLLKIRYPMEHGIVTDWNDMER 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  92 IWIHVYNSLK--INSDEHPILLTEAPLNPQKNKEKIAEVFFETFNVPALFISMQAILSLYSCGKTNGTVLDCGDGVCHCV 169
Cdd:cd10216   81 IWQYVYSKLQlnTFSEEHPVLLTEAPLNPRKNREKAAEVFFETFNVPALFVSMQAVLSLYASGRTTGVVLDSGDGVTHAV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 170 SIYEGYNITNTITRTDVAGRDITNYLSFLLRKNGHLFNTSSEMEVVKNMKENCCYVSFNMNKEKNSSEKAVTTLPYILPD 249
Cdd:cd10216  161 PIYEGFALPHSIRRVDIAGRDVTEYLQLLLRKSGYNFHTSAEFEIVREIKEKACYVALNPQKEEKLEEEKTEKAQYTLPD 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 250 GSQILIGSERYRAPEVLFNPSILGLEYLGLSELIVTSITRADMDLRKTLYSHIVLSGGTTLFQGFGDRLLNEIRKFAPKD 329
Cdd:cd10216  241 GSTIEIGPERFRAPEILFNPELIGLEYPGVHEVLVDSIQKSDLDLRKTLYSNIVLSGGSTLFKGFGDRLLSEVKKLAPKD 320
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 124505713 330 ITIRISAPPERKFSTFIGGSILASLATFKKIWISKQEFDEYGSVILHKKS 379
Cdd:cd10216  321 VKIRISAPPERLYSTWIGGSILASLSTFKKMWVSKKEYEEDGARILHRKT 370
ACTIN smart00268
Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily
12-380 5.67e-176

Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily


Pssm-ID: 214592 [Multi-domain]  Cd Length: 373  Bit Score: 494.08  E-value: 5.67e-176
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713    12 NQPVIIDNGTGYIKSGFAGEDIPSLVFPSYVGRPKYKRVMAGaVEGNIFVGNKAEEYRGLLKVTYPINHGIIQNWNDMEN 91
Cdd:smart00268   1 VPAIVIDNGSGTIKAGFAGEDFPQVVFPSIVGRPKDGKGMVG-DAKDIFVGDEAQEKRGGLELKYPIENGIVENWDDMEK 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713    92 IWIHVYNS-LKINSDEHPILLTEAPLNPQKNKEKIAEVFFETFNVPALFISMQAILSLYSCGKTNGTVLDCGDGVCHCVS 170
Cdd:smart00268  80 IWDYTFFNeLRVEPEEHPVLLTEPPMNPKSNREKILEIMFETFNFPALYIAIQAVLSLYASGRTTGLVIDSGDGVTHVVP 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713   171 IYEGYNITNTITRTDVAGRDITNYLSFLLRKNGHLFNTSSEMEVVKNMKENCCYVSFN----MNKEKNSSEKAVTTLPYI 246
Cdd:smart00268 160 VVDGYVLPHAIKRIDIAGRDITDYLKELLSERGYQFNSSAEFEIVREIKEKLCYVAEDfekeMKLARESSESSKLEKTYE 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713   247 LPDGSQILIGSERYRAPEVLFNPSILGLEYLGLSELIVTSITRADMDLRKTLYSHIVLSGGTTLFQGFGDRLLNEIRKFA 326
Cdd:smart00268 240 LPDGNTIKVGNERFRIPEILFSPELIGLEQKGIHELVYESIQKCDIDVRKDLYENIVLSGGSTLIPGFGERLEKELKQLA 319
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 124505713   327 PKDITIRISAPPERKFSTFIGGSILASLATFKKIWISKQEFDEYGSVILHKKSF 380
Cdd:smart00268 320 PKKLKVKVIAPPERKYSVWLGGSILASLSTFEDMWITKKEYEESGSQIVERKCF 373
Actin pfam00022
Actin;
12-380 1.74e-161

Actin;


Pssm-ID: 394979 [Multi-domain]  Cd Length: 407  Bit Score: 458.69  E-value: 1.74e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713   12 NQPVIIDNGTGYIKSGFAGEDIPSLVFPSYVGRPKYKRVMAgavEGNIFVGNKAEEYRGLLKVTYPINHGIIQNWNDMEN 91
Cdd:pfam00022   1 VSALVIDNGSHTTRAGFAGEDAPKAVIPSCVGKPRGTKVEA---ANKYYVGDEALTYRPGMEVRSPVEDGIVVDWDAMEE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713   92 IWIHVY-NSLKINSDEHPILLTEAPLNPQKNKEKIAEVFFETFNVPALFISMQAILSLYSCGKTNGTVLDCGDGVCHCVS 170
Cdd:pfam00022  78 IWEHVLkEELQVDPEEHPLLLTEPPWNPPANREKAAEIMFEKFGVPALYLAKNPVLSAFASGRTTGLVVDSGAGVTSVVP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  171 IYEGYNITNTITRTDVAGRDITNYLSFLLR------------------------------KNGHLFNTSSEMEVVKNMKE 220
Cdd:pfam00022 158 VHDGYVLQKAIRRSDLGGDFLTDYLRELLRsrnieitprylikskkpgdpapavtkrelpDTTYSYKTYQERRVLEEIKE 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  221 NCCYVSFN-MNKEKNSSEKAvtTLPYILPDGSQILIGSERYRAPEVLFNPSILGLEY--------LGLSELIVTSITRAD 291
Cdd:pfam00022 238 SVCYVSDDpFGDETTSSSIP--TRVYELPDGSTIILGAERFRVPEILFNPSLIGSESelpppqtaVGIPELIVDAINACD 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  292 MDLRKTLYSHIVLSGGTTLFQGFGDRLLNEIRKFAPKDITIRISAPP---ERKFSTFIGGSILASLATFKKIWISKQEFD 368
Cdd:pfam00022 316 VDLRPSLLANIVVTGGNSLFPGFTERLEKELAQLAPPGVKVKIIAPGntvERRYSAWIGGSILASLGTFQQMWVSKQEYE 395
                         410
                  ....*....|..
gi 124505713  369 EYGSVILHKKSF 380
Cdd:pfam00022 396 EHGASVVERKCK 407
syringactin NF040575
syringactin; Syringactin are close homologs of the normally eukaryotic protein actin, found in ...
313-378 1.30e-15

syringactin; Syringactin are close homologs of the normally eukaryotic protein actin, found in the plant pathogen Pseudomonas syringae and related species. This model was created, in part, to clarify that the family is real and distinct, rather than an artifact of eukaryotic contamination of bacterial genomic sequence data. As of the creation of this HMM, the family is uncharacterized.


Pssm-ID: 468549 [Multi-domain]  Cd Length: 132  Bit Score: 72.70  E-value: 1.30e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124505713 313 GFGDRLLNEIRKFAPKDITIRISAPPERKFSTFIGGSILASLATFKKIWISKQEFDEYGSVILHKK 378
Cdd:NF040575  66 GFYEKLKKSITEKAPKGALIGMTLDPKPESAAWRGAAMYAASEGFVEMAITKQEYDESGPSIVHRK 131
 
Name Accession Description Interval E-value
PTZ00466 PTZ00466
actin-like protein; Provisional
1-380 0e+00

actin-like protein; Provisional


Pssm-ID: 240426 [Multi-domain]  Cd Length: 380  Bit Score: 828.43  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713   1 MNNDYVNNIYPNQPVIIDNGTGYIKSGFAGEDIPSLVFPSYVGRPKYKRVMAGAVEGNIFVGNKAEEYRGLLKVTYPINH 80
Cdd:PTZ00466   1 KMNEYAKQLYSNQPIIIDNGTGYIKAGFAGEDVPNLVFPSYVGRPKYKRVMAGAVEGNIFVGNKAEEYRGLLKVTYPINH 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  81 GIIQNWNDMENIWIHVYNSLKINSDEHPILLTEAPLNPQKNKEKIAEVFFETFNVPALFISMQAILSLYSCGKTNGTVLD 160
Cdd:PTZ00466  81 GIIENWNDMENIWIHVYNSMKINSEEHPVLLTEAPLNPQKNKEKIAEVFFETFNVPALFISIQAILSLYSCGKTNGTVLD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 161 CGDGVCHCVSIYEGYNITNTITRTDVAGRDITNYLSFLLRKNGHLFNTSSEMEVVKNMKENCCYVSFNMNKEKNSSEKAV 240
Cdd:PTZ00466 161 CGDGVCHCVSIYEGYSITNTITRTDVAGRDITTYLGYLLRKNGHLFNTSAEMEVVKNMKENCCYVSFNMNKEKNSSEKAL 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 241 TTLPYILPDGSQILIGSERYRAPEVLFNPSILGLEYLGLSELIVTSITRADMDLRKTLYSHIVLSGGTTLFQGFGDRLLN 320
Cdd:PTZ00466 241 TTLPYILPDGSQILIGSERYRAPEVLFNPSILGLEYLGLSELIVTSITRADMDLRRTLYSHIVLSGGTTMFHGFGDRLLN 320
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 321 EIRKFAPKDITIRISAPPERKFSTFIGGSILASLATFKKIWISKQEFDEYGSVILHKKSF 380
Cdd:PTZ00466 321 EIRKFAPKDITIRISAPPERKFSTFIGGSILASLATFKKIWISKQEFDEYGSVILHRKTF 380
ASKHA_NBD_Arp1 cd10216
nucleotide-binding domain (NBD) of actin-related protein 1 (Arp1) and similar proteins; Arp1, ...
12-379 0e+00

nucleotide-binding domain (NBD) of actin-related protein 1 (Arp1) and similar proteins; Arp1, also called centractin, actin-like protein, alpha-centractin, actin-RPV, or centrosome-associated actin homolog, may be a component of a multi-subunit centrosomal complex involved in microtubule-based vesicle motility. In yeast, actin-related protein is essential for viability and is associated with the centrosome. In vertebrates, Arp1 is a core component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding. The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint. ARP1 forms the backbone filament of the dynactin rod structure and serves as the scaffold for the remaining subunits. It is required for proper orientation of the mitotic spindle. Arp1 is the only actin-related protein known to form actin-like filaments. Human Arp1/centractin is encoded by the ACTR1A gene.


Pssm-ID: 466820 [Multi-domain]  Cd Length: 370  Bit Score: 723.95  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  12 NQPVIIDNGTGYIKSGFAGEDIPSLVFPSYVGRPKYKRVMAGAVEGNIFVGNKAEEYRGLLKVTYPINHGIIQNWNDMEN 91
Cdd:cd10216    1 NQPVVIDNGSGVIKAGFAGDDIPKVVFPSYVGRPKHVRVMAGALEGDVFVGPKAEEHRGLLKIRYPMEHGIVTDWNDMER 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  92 IWIHVYNSLK--INSDEHPILLTEAPLNPQKNKEKIAEVFFETFNVPALFISMQAILSLYSCGKTNGTVLDCGDGVCHCV 169
Cdd:cd10216   81 IWQYVYSKLQlnTFSEEHPVLLTEAPLNPRKNREKAAEVFFETFNVPALFVSMQAVLSLYASGRTTGVVLDSGDGVTHAV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 170 SIYEGYNITNTITRTDVAGRDITNYLSFLLRKNGHLFNTSSEMEVVKNMKENCCYVSFNMNKEKNSSEKAVTTLPYILPD 249
Cdd:cd10216  161 PIYEGFALPHSIRRVDIAGRDVTEYLQLLLRKSGYNFHTSAEFEIVREIKEKACYVALNPQKEEKLEEEKTEKAQYTLPD 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 250 GSQILIGSERYRAPEVLFNPSILGLEYLGLSELIVTSITRADMDLRKTLYSHIVLSGGTTLFQGFGDRLLNEIRKFAPKD 329
Cdd:cd10216  241 GSTIEIGPERFRAPEILFNPELIGLEYPGVHEVLVDSIQKSDLDLRKTLYSNIVLSGGSTLFKGFGDRLLSEVKKLAPKD 320
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 124505713 330 ITIRISAPPERKFSTFIGGSILASLATFKKIWISKQEFDEYGSVILHKKS 379
Cdd:cd10216  321 VKIRISAPPERLYSTWIGGSILASLSTFKKMWVSKKEYEEDGARILHRKT 370
ASKHA_NBD_actin_Arp-T1-3 cd13397
nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar ...
14-371 0e+00

nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar proteins; The family includes actin and human actin-related proteins T1, T2, and T3. Actin is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. It is a highly dynamic structural protein network involved in processes such as cell contraction, cell motility, vesicle trafficking, intracellular organization, cytokinesis, endocytosis and apoptosis. Arp-T1, encoded by ACTRT1/ARPT1 gene expressed in testis, negatively regulates the Hedgehog (SHH) signaling, binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression. Arp-T2 (also called actin-related protein M2; encoded by ACTRT2/ARPM2 gene expressed in testis and various other cell types) and Arp-T3 (also called actin-related protein M1; encoded by ACTRT3/ARPM1 gene expressed in all tested human tissues) play general roles in the organization of the cytoskeleton like other cytoplasmic actin-related proteins.


Pssm-ID: 466848 [Multi-domain]  Cd Length: 359  Bit Score: 571.82  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  14 PVIIDNGTGYIKSGFAGEDIPSLVFPSYVGRPKYKRVMAGAVEGNIFVGNKAEEYRGLLKVTYPINHGIIQNWNDMENIW 93
Cdd:cd13397    2 AVVIDNGSGLIKAGFAGEDLPRAVFPSVVGRPKYKAVMLGAGQKEVYVGDEAQEKRGVLTLSYPIEHGIVTNWDDMEKIW 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  94 IHVY-NSLKINSDEHPILLTEAPLNPQKNKEKIAEVFFETFNVPALFISMQAILSLYSCGKTNGTVLDCGDGVCHCVSIY 172
Cdd:cd13397   82 HHTFeNELRVKPEEHPVLLTEAPLNPKQNREKMAEIMFETFGVPAFYVAIQAVLSLYSSGRTTGLVLDSGDGVTHTVPIY 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 173 EGYNITNTITRTDVAGRDITNYLSFLLRKNGHLFNTSSEMEVVKNMKENCCYVSFNMNKEKNSSEKAVTTlPYILPDGSQ 252
Cdd:cd13397  162 EGYALPHAVQRLDLAGRDLTEYLMKLLKERGHSFTTTAEREIVRDIKEKLCYVALDYEEELKKKSEELEK-EYTLPDGQV 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 253 ILIGSERYRAPEVLFNPSILGLEYLGLSELIVTSITRADMDLRKTLYSHIVLSGGTTLFQGFGDRLLNEIRKFAPKDITI 332
Cdd:cd13397  241 IKIGSERFRCPEALFRPSLIGREAPGIHKLVYNSIMKCDIDIRKDLYSNIVLSGGSTMFPGLPERLQKELEALAPSSTKV 320
                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 124505713 333 RISAPPERKFSTFIGGSILASLATFKKIWISKQEFDEYG 371
Cdd:cd13397  321 KVIAPPERKYSVWIGGSILASLSTFKSMWITRAEYDEFG 359
ASKHA_NBD_actin cd10224
nucleotide-binding domain (NBD) of actin and similar proteins; Actin is a ubiquitous protein ...
13-374 0e+00

nucleotide-binding domain (NBD) of actin and similar proteins; Actin is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. It is a highly dynamic structural protein network involved in processes such as cell contraction, cell motility, vesicle trafficking, intracellular organization, cytokinesis, endocytosis and apoptosis. Actin is a monomeric globular protein (G-actin) that reversibly polymerizes to form filaments (F-actin). Each actin protomer binds one molecule of ATP and either calcium or magnesium ions. At low salt concentrations, actin exists as a monomer, and as the salt concentration rises F-actin forms, with the consequent hydrolysis of ATP. F-actin assembly is in constant flux with G-actin association occurring at the barbed end (+) and its disassociation at the pointed end (-). Actin monomers that have been released from the pointed end can be reused, if the ADP is exchanged for ATP. F-actin filaments can assemble into higher order structures, for example branched F-actin, and stress fibers. Actin binding proteins regulate actin filament dynamics by a range of functions including actin severing, depolymerizing, capping, stabilizing and de novo actin polymerization. Actins interaction with myosin is the basis of muscular contraction and many aspects of cell motility. In vertebrates there are three main groups of actin isoforms, alpha, beta and gamma. The alpha actins found in muscle tissues are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. In plants there are many isoforms which are probably involved in a variety of functions such as cytoplasmic streaming, cell shape determination, tip growth, graviperception, cell wall deposition, etc.


Pssm-ID: 466823  Cd Length: 365  Bit Score: 507.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  13 QPVIIDNGTGYIKSGFAGEDIPSLVFPSYVGRPKYKRVMAGAVEGNIFVGNKAEEYRGLLKVTYPINHGIIQNWNDMENI 92
Cdd:cd10224    1 AALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  93 WIHV-YNSLKINSDEHPILLTEAPLNPQKNKEKIAEVFFETFNVPALFISMQAILSLYSCGKTNGTVLDCGDGVCHCVSI 171
Cdd:cd10224   81 WHHTfYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 172 YEGYNITNTITRTDVAGRDITNYLSFLLRKNGHLFNTSSEMEVVKNMKENCCYVSFNMNKE-KNSSEKAVTTLPYILPDG 250
Cdd:cd10224  161 YEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEmQTAASSSSLEKSYELPDG 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 251 SQILIGSERYRAPEVLFNPSILGLEYLGLSELIVTSITRADMDLRKTLYSHIVLSGGTTLFQGFGDRLLNEIRKFAPKDI 330
Cdd:cd10224  241 QVITIGNERFRCPEALFQPSFLGMEAAGIHETTYNSIMKCDVDIRKDLYANIVLSGGTTMFPGIADRMQKEITALAPSTM 320
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 124505713 331 TIRISAPPERKFSTFIGGSILASLATFKKIWISKQEFDEYGSVI 374
Cdd:cd10224  321 KIKIVAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSI 364
ACTIN smart00268
Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily
12-380 5.67e-176

Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily


Pssm-ID: 214592 [Multi-domain]  Cd Length: 373  Bit Score: 494.08  E-value: 5.67e-176
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713    12 NQPVIIDNGTGYIKSGFAGEDIPSLVFPSYVGRPKYKRVMAGaVEGNIFVGNKAEEYRGLLKVTYPINHGIIQNWNDMEN 91
Cdd:smart00268   1 VPAIVIDNGSGTIKAGFAGEDFPQVVFPSIVGRPKDGKGMVG-DAKDIFVGDEAQEKRGGLELKYPIENGIVENWDDMEK 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713    92 IWIHVYNS-LKINSDEHPILLTEAPLNPQKNKEKIAEVFFETFNVPALFISMQAILSLYSCGKTNGTVLDCGDGVCHCVS 170
Cdd:smart00268  80 IWDYTFFNeLRVEPEEHPVLLTEPPMNPKSNREKILEIMFETFNFPALYIAIQAVLSLYASGRTTGLVIDSGDGVTHVVP 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713   171 IYEGYNITNTITRTDVAGRDITNYLSFLLRKNGHLFNTSSEMEVVKNMKENCCYVSFN----MNKEKNSSEKAVTTLPYI 246
Cdd:smart00268 160 VVDGYVLPHAIKRIDIAGRDITDYLKELLSERGYQFNSSAEFEIVREIKEKLCYVAEDfekeMKLARESSESSKLEKTYE 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713   247 LPDGSQILIGSERYRAPEVLFNPSILGLEYLGLSELIVTSITRADMDLRKTLYSHIVLSGGTTLFQGFGDRLLNEIRKFA 326
Cdd:smart00268 240 LPDGNTIKVGNERFRIPEILFSPELIGLEQKGIHELVYESIQKCDIDVRKDLYENIVLSGGSTLIPGFGERLEKELKQLA 319
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 124505713   327 PKDITIRISAPPERKFSTFIGGSILASLATFKKIWISKQEFDEYGSVILHKKSF 380
Cdd:smart00268 320 PKKLKVKVIAPPERKYSVWLGGSILASLSTFEDMWITKKEYEESGSQIVERKCF 373
Actin pfam00022
Actin;
12-380 1.74e-161

Actin;


Pssm-ID: 394979 [Multi-domain]  Cd Length: 407  Bit Score: 458.69  E-value: 1.74e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713   12 NQPVIIDNGTGYIKSGFAGEDIPSLVFPSYVGRPKYKRVMAgavEGNIFVGNKAEEYRGLLKVTYPINHGIIQNWNDMEN 91
Cdd:pfam00022   1 VSALVIDNGSHTTRAGFAGEDAPKAVIPSCVGKPRGTKVEA---ANKYYVGDEALTYRPGMEVRSPVEDGIVVDWDAMEE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713   92 IWIHVY-NSLKINSDEHPILLTEAPLNPQKNKEKIAEVFFETFNVPALFISMQAILSLYSCGKTNGTVLDCGDGVCHCVS 170
Cdd:pfam00022  78 IWEHVLkEELQVDPEEHPLLLTEPPWNPPANREKAAEIMFEKFGVPALYLAKNPVLSAFASGRTTGLVVDSGAGVTSVVP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  171 IYEGYNITNTITRTDVAGRDITNYLSFLLR------------------------------KNGHLFNTSSEMEVVKNMKE 220
Cdd:pfam00022 158 VHDGYVLQKAIRRSDLGGDFLTDYLRELLRsrnieitprylikskkpgdpapavtkrelpDTTYSYKTYQERRVLEEIKE 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  221 NCCYVSFN-MNKEKNSSEKAvtTLPYILPDGSQILIGSERYRAPEVLFNPSILGLEY--------LGLSELIVTSITRAD 291
Cdd:pfam00022 238 SVCYVSDDpFGDETTSSSIP--TRVYELPDGSTIILGAERFRVPEILFNPSLIGSESelpppqtaVGIPELIVDAINACD 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  292 MDLRKTLYSHIVLSGGTTLFQGFGDRLLNEIRKFAPKDITIRISAPP---ERKFSTFIGGSILASLATFKKIWISKQEFD 368
Cdd:pfam00022 316 VDLRPSLLANIVVTGGNSLFPGFTERLEKELAQLAPPGVKVKIIAPGntvERRYSAWIGGSILASLGTFQQMWVSKQEYE 395
                         410
                  ....*....|..
gi 124505713  369 EYGSVILHKKSF 380
Cdd:pfam00022 396 EHGASVVERKCK 407
PTZ00004 PTZ00004
actin-2; Provisional
13-380 1.20e-158

actin-2; Provisional


Pssm-ID: 240225 [Multi-domain]  Cd Length: 378  Bit Score: 450.38  E-value: 1.20e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  13 QPVIIDNGTGYIKSGFAGEDIPSLVFPSYVGRPKYKRVMAGAVEGNIFVGNKAEEYRGLLKVTYPINHGIIQNWNDMENI 92
Cdd:PTZ00004   7 NAAVVDNGSGMVKAGFAGDDAPRCVFPSIVGRPKNPGIMVGMEEKDCYVGDEAQDKRGILTLKYPIEHGIVTNWDDMEKI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  93 WIHV-YNSLKINSDEHPILLTEAPLNPQKNKEKIAEVFFETFNVPALFISMQAILSLYSCGKTNGTVLDCGDGVCHCVSI 171
Cdd:PTZ00004  87 WHHTfYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETHNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPI 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 172 YEGYNITNTITRTDVAGRDITNYLSFLLRKNGHLFNTSSEMEVVKNMKENCCYVSFNMNKEKNSSEKAVTTL--PYILPD 249
Cdd:PTZ00004 167 YEGYSLPHAIHRLDVAGRDLTEYMMKILHERGTTFTTTAEKEIVRDIKEKLCYIALDFDEEMGNSAGSSDKYeeSYELPD 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 250 GSQILIGSERYRAPEVLFNPSILGLEY-LGLSELIVTSITRADMDLRKTLYSHIVLSGGTTLFQGFGDRLLNEIRKFAPK 328
Cdd:PTZ00004 247 GTIITVGSERFRCPEALFQPSLIGKEEpPGIHELTFQSINKCDIDIRKDLYGNIVLSGGTTMYRGLPERLTKELTTLAPS 326
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 124505713 329 DITIRISAPPERKFSTFIGGSILASLATFKKIWISKQEFDEYGSVILHKKSF 380
Cdd:PTZ00004 327 TMKIKVVAPPERKYSVWIGGSILSSLPTFQQMWVTKEEYDESGPSIVHRKCF 378
PTZ00281 PTZ00281
actin; Provisional
13-380 9.78e-153

actin; Provisional


Pssm-ID: 173506 [Multi-domain]  Cd Length: 376  Bit Score: 435.67  E-value: 9.78e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  13 QPVIIDNGTGYIKSGFAGEDIPSLVFPSYVGRPKYKRVMAGAVEGNIFVGNKAEEYRGLLKVTYPINHGIIQNWNDMENI 92
Cdd:PTZ00281   7 QALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHTGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  93 WIHV-YNSLKINSDEHPILLTEAPLNPQKNKEKIAEVFFETFNVPALFISMQAILSLYSCGKTNGTVLDCGDGVCHCVSI 171
Cdd:PTZ00281  87 WHHTfYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVSHTVPI 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 172 YEGYNITNTITRTDVAGRDITNYLSFLLRKNGHLFNTSSEMEVVKNMKENCCYVSFNMNKE-KNSSEKAVTTLPYILPDG 250
Cdd:PTZ00281 167 YEGYALPHAILRLDLAGRDLTDYMMKILTERGYSFTTTAEREIVRDIKEKLAYVALDFEAEmQTAASSSALEKSYELPDG 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 251 SQILIGSERYRAPEVLFNPSILGLEYLGLSELIVTSITRADMDLRKTLYSHIVLSGGTTLFQGFGDRLLNEIRKFAPKDI 330
Cdd:PTZ00281 247 QVITIGNERFRCPEALFQPSFLGMESAGIHETTYNSIMKCDVDIRKDLYGNVVLSGGTTMFPGIADRMNKELTALAPSTM 326
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 124505713 331 TIRISAPPERKFSTFIGGSILASLATFKKIWISKQEFDEYGSVILHKKSF 380
Cdd:PTZ00281 327 KIKIIAPPERKYSVWIGGSILASLSTFQQMWISKEEYDESGPSIVHRKCF 376
ASKHA_NBD_Arp2 cd10220
nucleotide-binding domain (NBD) of actin-related protein2 (Arp2) and similar proteins; Arp2, ...
13-377 4.21e-146

nucleotide-binding domain (NBD) of actin-related protein2 (Arp2) and similar proteins; Arp2, also called actin-like protein 2, is the ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex is comprised of 7 proteins (Arp2, Arp3, and five conserved proteins, ARPC1-5). It generates cytoplasmic branched filaments networks, by promoting nucleation of actin filaments as 70 degrees branches on the side of older filaments. It is activated, by simultaneously binding to a pre-existing filament and a nucleation promoting factor plus an actin monomer. Daughter branches subsequently detach/debranch from the mother filament. Its Arp2 and Arp3 subunits must be loaded with ATP for it to initiate the assembly of branched actin filaments. ATP hydrolysis may be required for branch initiation or debranching. The Arp2/3 complex is also found in the nucleus where it plays a role in promoting de novo actin polymerization and in RNA polymerase II-dependent transcription. This may in part be through regulating nuclear actin polymerization in a way like its function in the cytoplasm. Human Arp2 is encoded by the ACTR2 gene.


Pssm-ID: 466821  Cd Length: 381  Bit Score: 418.89  E-value: 4.21e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  13 QPVIIDNGTGYIKSGFAGEDIPSLVFPSYVGRP--KYKRVMAGAVEGNIFVGNKAEEYRGLLKVTYPINHGIIQNWNDME 90
Cdd:cd10220    1 KVVVCDNGTGFVKCGFAGSNFPEHVFPSLVGRPilRAEEKVGDIEIKDIMVGDEASELRSMLEVTYPMENGIVRNWDDME 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  91 NIWIHV-YNSLKINSDEHPILLTEAPLNPQKNKEKIAEVFFETFNVPALFISMQAILSLYSCGKTNGTVLDCGDGVCHCV 169
Cdd:cd10220   81 HLWDYTfGEKLKIDPRECKILLTEPPMNPTKNREKMVEVMFEKYGFAGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHIV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 170 SIYEGYNITNTITRTDVAGRDITNYLSFLLRKNGHLFNTSSEMEVVKNMKENCCYVSFNMNKEKN-SSEKAVTTLPYILP 248
Cdd:cd10220  161 PVYEGFSLPHLTRRLDVAGRDITRYLIKLLLLRGYAFNRTADFETVREIKEKLCYVAYDIELEQKlALETTVLVESYTLP 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 249 DGSQILIGSERYRAPEVLFNPSILGLEYLGLSELIVTSITRADMDLRKTLYSHIVLSGGTTLFQGFGDRLLNEIRKF--- 325
Cdd:cd10220  241 DGRVIKVGGERFEAPEALFQPHLIDVEGPGIAELLFNTIQAADIDTRPELYKHIVLSGGSTMYPGLPSRLEKEIKQLyle 320
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124505713 326 --------APKDITIRISAPPERKFSTFIGGSILASLATFKK-IWISKQEFDEYGSVILHK 377
Cdd:cd10220  321 rvlkgdteRLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDeFWITRQEYEEQGVRVLDK 381
ASKHA_NBD_ACTL7 cd10214
nucleotide-binding domain (NBD) of the actin-like protein 7 (ACTL7)-like family; The ...
14-378 2.83e-129

nucleotide-binding domain (NBD) of the actin-like protein 7 (ACTL7)-like family; The ACTL7-like family includes ACTL7A, ACTL7B and ACTL9 (also known as ACTL7C). In mammalian, ACTL7A is expressed in a wide variety of adult tissues, while the ACTL7B is expressed in spermatids through the elongation phase of spermatid development. ACTL7A, also called actin-like-7-alpha, or T-ACTIN-2 in mouse, may play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis. ACTL7B, also called actin-like-7-beta, acts as a key regulator of spermiogenesis that is required for male fertility. ACTL9 is a testis-specific protein that plays an important role in fusion of proacrosomal vesicles and perinuclear theca formation.


Pssm-ID: 466819 [Multi-domain]  Cd Length: 368  Bit Score: 375.61  E-value: 2.83e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  14 PVIIDNGTGYIKSGFAGEDIPSLVFPSYVGRPKYKRVMAGAVEGNIFVGNKAEEYRGLLKVTYPINHGIIQNWNDMENIW 93
Cdd:cd10214    5 AVIIDLGTGYCKAGFAGQPRPSYVISSTVGKPPQESAKTGDNRKETFVGKELANVEPPLKLVNPLRHGIVVDWDCVQDIW 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  94 IHVY-NSLKINSDEHPILLTEAPLNPQKNKEKIAEVFFETFNVPALFISMQAILSLYSCGKTNGTVLDCGDGVCHCVSIY 172
Cdd:cd10214   85 EYIFeKEMKILPEEHAVLVSDPPLSPTTNREKYAELMFETFSIPAMHIAYQSRLSLYSYGRTSGLVVESGHGVSYVVPIH 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 173 EGYNITNTITRTDVAGRDITNYLSFLLRKNGHLFnTSSEMEVVKNMKENCCYVSFNMNKEKN--SSEKAVTtlpYILPDG 250
Cdd:cd10214  165 EGYNLPHITGRADYAGSDLTAYLMKLLNEAGNKF-TDDQLHIVEDIKKKCCYVALDFEEEMGlpPQEYTVD---YELPDG 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 251 SQILIGSERYRAPEVLFNPSILGLEYLGLSELIVTSITRADMDLRKTLYSHIVLSGGTTLFQGFGDRLLNEIRKFAPKDI 330
Cdd:cd10214  241 HLITIGKERFRCPEMLFNPSLIGSKQPGLHTLTMNSLNKCDANLKKDLAKNILLCGGSTMFDGFPDRFQKELSKLCPNDN 320
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 124505713 331 TIrISAPPERKFSTFIGGSILASLATFKKIWISKQEFDEYGSVILHKK 378
Cdd:cd10214  321 PI-VAASPERKYSVWTGGSILASLKSFQQLWVRRREYEERGPFVIYRK 367
ASKHA_NBD_actin-like cd10169
nucleotide-binding domain (NBD) of actin and actin-related proteins (ARPs); Actin is ...
15-371 6.67e-124

nucleotide-binding domain (NBD) of actin and actin-related proteins (ARPs); Actin is ubiquitous in eukaryotes, and the major component of the actin cytoskeleton; monomeric globular protein (G-actin) reversibly polymerizes to form filaments (F-actin). Each actin protomer binds one molecule of ATP and either calcium or magnesium ions. F-actin filaments form with the consequent hydrolysis of ATP. Some actin-related proteins (Arps) have roles in cytoskeletal functions, such as actin polymerization (Arp2/3) and dynein motor activity (Arp1). Both conventional actin and specific Arps have been implicated in chromatin remodeling and/or transcription regulation. The actin/ARP family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466810 [Multi-domain]  Cd Length: 258  Bit Score: 357.57  E-value: 6.67e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  15 VIIDNGTGYIKSGFAGEDIPSLVFPsyvgrpkykrvmagavegnifvgnkaeeyrgllkvtypinhgiiqnWNDMENIWI 94
Cdd:cd10169    1 IVIDNGSGTIKAGFAGEDAPRLIFP----------------------------------------------WDDMEKIWE 34
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  95 HVYNS-LKINSDEHPILLTEAPLNPQKNKEKIAEVFFETFNVPALFISMQAILSLYSCGKTNGTVLDCGDGVCHCVSIYE 173
Cdd:cd10169   35 HVFYNlLRVDPEEHPVLLTEPPLNPKANREKLAEILFETFNVPSLYIANQAVLSLYASGRTTGLVVDSGEGVTHIVPVYE 114
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 174 GYNITNTITRTDVAGRDITNYLSFLLRKNGHLFNTSSEMEVVKNMKENCCyvsfnmnkeknssekavttlpyilpdgsqi 253
Cdd:cd10169  115 GYVLPHAVRRLDIGGRDLTDYLAKLLREKGYSFSTSAEREIVRDIKEKLC------------------------------ 164
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 254 ligseryrapevlfnpsilgleylGLSELIVTSITRADMDLRKTLYSHIVLSGGTTLFQGFGDRLLNEIRKFAPKDITIR 333
Cdd:cd10169  165 ------------------------GLHELIYDSIMKCDIDLRKELYSNIVLSGGTTLFPGFAERLQKELSKLAPSSVKVK 220
                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 124505713 334 ISAPPERKFSTFIGGSILASLATFKKIWISKQEFDEYG 371
Cdd:cd10169  221 VIAPPERKYSAWIGGSILASLSTFQQMWITKEEYEEHG 258
PTZ00452 PTZ00452
actin; Provisional
10-380 4.61e-122

actin; Provisional


Pssm-ID: 185631  Cd Length: 375  Bit Score: 357.53  E-value: 4.61e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  10 YPnqPVIIDNGTGYIKSGFAGEDIPSLVFPSYVGRPKYKRVMAGAVEGNIFVGNKAEEYRGLLKVTYPINHGIIQNWNDM 89
Cdd:PTZ00452   5 YP--AVVIDNGSGYCKIGIAGDDAPTSCFPAIVGRSKQNDGIFSTFNKEYYVGEEAQAKRGVLAIKEPIQNGIINSWDDI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  90 ENIWIHV-YNSLKINSDEHPILLTEAPLNPQKNKEKIAEVFFETFNVPALFISMQAILSLYSCGKTNGTVLDCGDGVCHC 168
Cdd:PTZ00452  83 EIIWHHAfYNELCMSPEDQPVFMTDAPMNSKFNRERMTQIMFETFNTPCLYISNEAVLSLYTSGKTIGLVVDSGEGVTHC 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 169 VSIYEGYNITNTITRTDVAGRDITNYLSFLLRKNGHLFNTSSEMEVVKNMKENCCYVSFNMNKEKN-SSEKAVTTLPYIL 247
Cdd:PTZ00452 163 VPVFEGHQIPQAITKINLAGRLCTDYLTQILQELGYSLTEPHQRIIVKNIKERLCYTALDPQDEKRiYKESNSQDSPYKL 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 248 PDGSQILIGSERYRAPEVLFNPSILGLEYLGLSELIVTSITRADMDLRKTLYSHIVLSGGTTLFQGFGDRLLNEIRKFAP 327
Cdd:PTZ00452 243 PDGNILTIKSQKFRCSEILFQPKLIGLEVAGIHHLAYSSIKKCDLDLRQELCRNIVLSGGTTLFPGIANRLSNELTNLVP 322
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 124505713 328 KDITIRISAPPERKFSTFIGGSILASLATFKKIWISKQEFDEYGSVILHKKSF 380
Cdd:PTZ00452 323 SQLKIQVAAPPDRRFSAWIGGSIQCTLSTQQPQWIKRQEYDEQGPSIVHRKCF 375
ASKHA_NBD_Arp4_ACTL6-like cd13395
nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The ...
15-371 7.43e-120

nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The Arp4-like subfamily includes Arp4, also called actin-like protein 4, from fungi and plants. Saccharomyces cerevisiae Arp4 acts synergistically with Arp8 to depolymerize F-actin; it binds ATP, but unlike conventional actin, does not form filaments. It is a component of the NuA4 histone acetyltransferase complex, the chromatin-remodeling INO80 complex and the SWR1 chromatin remodeling complex. Arabidopsis thaliana Arp4 is involved in several developmental processes including organization of plant organs, flowering time, anther development, flower senescence and fertility, probably by regulating the chromatin structure. This family also includes human homologs of yeast and plant, which are actin-like protein 6A (encoded by the ACTL6A gene; also known as ArpNbeta, 53 kDa BRG1-associated factor A/BRG1-associated factor 53A/BAF35A, and INO80 complex subunit K/INO80K) and actin-like protein 6B (encoded by the ACTL6B gene; also known as ArpNalpha, 53 kDa BRG1-associated factor B/BRG1-associated factor 53B/BAF35B). ACTL6A and ACTL6B are involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). They are components of numerous complexes with chromatin remodeling and histone acetyltransferase activity. ACTL6A is also a putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Schizosaccharomyces pombe actin-related protein 42 (Arp42) is also included in this family. It is also a component of SWI/SNF and RSC complexes.


Pssm-ID: 466846 [Multi-domain]  Cd Length: 413  Bit Score: 353.02  E-value: 7.43e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  15 VIIDNGTGYIKSGFAGEDIPSLVFPSYVGrpkykrVMAGAVEGNIFVGNKAEEYRGLLK-------------VTYPINHG 81
Cdd:cd13395    7 LVLDIGSYSTRAGYAGEDTPKAVFPSVVG------VVTDDDDAEDYVGGSGEKKRKYYIgtnsigvprpnmeVISPLKDG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  82 IIQNWNDMENIWIHVYNS-LKINSDEHPILLTEAPLNPQKNKEKIAEVFFETFNVPALFISMQAILSLYSCGKTNGTVLD 160
Cdd:cd13395   81 LIEDWDAFEKLWDHALKNrLRVDPSEHPLLLTEPSWNTRANREKLTELMFEKYNVPAFFLAKNAVLSAFANGRSTALVVD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 161 CGDGVCHCVSIYEGYNITNTITRTDVAGRDITNYLSFLLRKNGH--------------------------LFNTSS---- 210
Cdd:cd13395  161 SGATSTSVVPVHDGYVLQKAIVRSPLGGDFLTDQLLKLLESKNIeiiprymikskepveggapakytkkdLPNTTSsyhr 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 211 --EMEVVKNMKENCCYVSfnMNKEKNSSEKAVTTLPYILPDGSQILIGSERYRAPEVLFNPSIL---------GLEYLGL 279
Cdd:cd13395  241 ymVRRVLQDFKESVCQVS--DSPFDESEAASIPTVSYELPDGYNIEFGAERFKIPELLFDPSLVkgipappseGNELLGL 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 280 SELIVTSITRADMDLRKTLYSHIVLSGGTTLFQGFGDRLLNEIRKFAPKDITIRISAPP---ERKFSTFIGGSILASLAT 356
Cdd:cd13395  319 PQLVYTSIGSCDVDIRPELYGNVVLTGGNSLLPGFTDRLNRELSEKAPGSLKLKILASGntvERRFSSWIGGSILASLGS 398
                        410
                 ....*....|....*
gi 124505713 357 FKKIWISKQEFDEYG 371
Cdd:cd13395  399 FQQMWISKQEYEEHG 413
PTZ00280 PTZ00280
Actin-related protein 3; Provisional
15-374 3.36e-105

Actin-related protein 3; Provisional


Pssm-ID: 240343 [Multi-domain]  Cd Length: 414  Bit Score: 315.90  E-value: 3.36e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  15 VIIDNGTGYIKSGFAGEDIPSLVFPS-YVGRPKYKRVMAGAVEGNI--FVGNKAEEYRGLLKVTYPINHGIIQNWNDMEN 91
Cdd:PTZ00280   7 VVIDNGTGYTKMGYAGNTEPTYIIPTlIADNSKQSRRRSKKGFEDLdfYIGDEALAASKSYTLTYPMKHGIVEDWDLMEK 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  92 IWIH-VYNSLKINSDEHPILLTEAPLNPQKNKEKIAEVFFETFNVPALFISMQAILSLYS----------CGKTNGTVLD 160
Cdd:PTZ00280  87 FWEQcIFKYLRCEPEEHYFILTEPPMNPPENREYTAEIMFETFNVKGLYIAVQAVLALRAswtskkakelGGTLTGTVID 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 161 CGDGVCHCVSIYEGYNITNTITRTDVAGRDITNYLSFLLRKNGHLFNTSSEMEVVKNMKENCCYVSFNMNKE-------- 232
Cdd:PTZ00280 167 SGDGVTHVIPVVDGYVIGSSIKHIPLAGRDITNFIQQMLRERGEPIPAEDILLLAQRIKEKYCYVAPDIAKEfekydsdp 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 233 -----KNSSEKAVTTLPYilpdgsQILIGSERYRAPEVLFNPSILGLEY-LGLSELIVTSITRADMDLRKTLYSHIVLSG 306
Cdd:PTZ00280 247 knhfkKYTAVNSVTKKPY------TVDVGYERFLGPEMFFHPEIFSSEWtTPLPEVVDDAIQSCPIDCRRPLYKNIVLSG 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 307 GTTLFQGFGDRLLNEIRKFA----------------PKDITIRISAPPERKFSTFIGGSILASLATFKKIWISKQEFDEY 370
Cdd:PTZ00280 321 GSTMFKGFDKRLQRDVRKRVdrrlkkaeelsggklkPIPIDVNVVSHPRQRYAVWYGGSMLASSPEFEKVCHTKAEYDEY 400

                 ....
gi 124505713 371 GSVI 374
Cdd:PTZ00280 401 GPSI 404
ASKHA_NBD_Arp3-like cd10221
nucleotide-binding domain (NBD) of actin-related protein3 (Arp3) and similar proteins; Arp3, ...
14-374 5.61e-104

nucleotide-binding domain (NBD) of actin-related protein3 (Arp3) and similar proteins; Arp3, also called actin-like protein 3, is the ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex is comprised of 7 proteins (Arp2, Arp3, and five conserved proteins, ARPC1-5). It generates cytoplasmic branched filaments networks, by promoting nucleation of actin filaments as 70 degrees branches on the side of older filaments. It is activated, by simultaneously binding to a pre-existing filament and a nucleation promoting factor plus an actin monomer. Daughter branches subsequently detach/debranch from the mother filament. Its Arp2 and Arp3 subunits must be loaded with ATP for it to initiate the assembly of branched actin filaments. ATP hydrolysis may be required for branch initiation or debranching. The Arp2/3 complex is also found in the nucleus where it plays a role in promoting de novo actin polymerization and in RNA polymerase II-dependent transcription. This may in part be through regulating nuclear actin polymerization in a way like its function in the cytoplasm. Human Arp3 and Arp3B are encoded by the ACTR3 and ACTR3B genes respectively. Arp3B is also known as actin-related protein Arp4.


Pssm-ID: 466822  Cd Length: 404  Bit Score: 312.20  E-value: 5.61e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  14 PVIIDNGTGYIKSGFAGEDIPSLVFPSYVGRPKYKRVMAGAVEG-------NIFVGNKAEEYRGLLKVTYPINHGIIQNW 86
Cdd:cd10221    1 AVVIDNGTGYTKMGYAGNTEPQFIIPTVIAIKESAKVGDGQRRSkkgiedlDFYIGDEALANSPTYALKYPIRHGIVEDW 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  87 NDMENIWIH-VYNSLKINSDEHPILLTEAPLNPQKNKEKIAEVFFETFNVPALFISMQAILSLYSCGKTN--------GT 157
Cdd:cd10221   81 DLMERFWEQcIFKYLRCEPEDHYFLLTEPPLNPPENREYTAEIMFETFNVPGLYIAVQAVLALAASWTSRkvgertltGT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 158 VLDCGDGVCHCVSIYEGYNITNTITRTDVAGRDITNYLSFLLRKNGHLFNTSSEMEVVKNMKENCCYVSFNMNKE----- 232
Cdd:cd10221  161 VIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREEGIPPEDSLEVAKRIKERYCYVCPDIVKEfakyd 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 233 --------KNSSEKAVTTLPYilpdgsQILIGSERYRAPEVLFNPSILGLEYL-GLSELIVTSITRADMDLRKTLYSHIV 303
Cdd:cd10221  241 sdpakyikQYTGINSVTGKPY------TVDVGYERFLAPEIFFNPEIASSDFTtPLPEVVDQVIQSCPIDTRRGLYKNIV 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 304 LSGGTTLFQGFGDRLLNEIRKF----------------APKDITIRISAPPERKFSTFIGGSILASLATFKKIWISKQEF 367
Cdd:cd10221  315 LSGGSTMFKDFGRRLQRDVKRIvdarlkaseelsggklKPKPIDVNVISHPMQRYAVWFGGSMLASTPEFYTVCHTKAEY 394

                 ....*..
gi 124505713 368 DEYGSVI 374
Cdd:cd10221  395 EEYGPSI 401
ASKHA_NBD_Arp6 cd10210
nucleotide-binding domain (NBD) of actin-related protein6 (Arp6) and similar proteins; Arp6, ...
15-371 1.60e-78

nucleotide-binding domain (NBD) of actin-related protein6 (Arp6) and similar proteins; Arp6, also called actin-like protein 6, is required for formation and/or maintenance of proper nucleolar structure and function, plays a dual role in the regulation of ribosomal DNA (rDNA) transcription. In the presence of high glucose, Arp6 maintains active rDNA transcription through H2A.Z deposition and under glucose starvation, it is required for the repression of rDNA transcription, and this function may be independent of H2A.Z. Arp6 is also required for telomere silencing in both fission and budding yeast. It is a component of the budding yeast and Arabidopsis SWR1 complex (SWR1C) and the human SWI2/SNF2-related CBP activator protein (SRCAP) chromatin remodeling complexes which catalyze the exchange of the histone H2A with the H2AZ. Drosophila Arp6 colocalizes with HP1 (heterochromatin protein 1) in the pericentric heterochromatin, and vertebrate Arp6 also interacts with HP1. Human Arp6 is encoded by the ACTR6 gene. Arabidopsis thaliana ACTIN RELATED PROTEIN 6/EARLY IN SHORT DAYS 1/SUPPRESSOR OF FRIGIDA 3 (encoded by ARP6/ESD1/SUF3) participates in regulating several leaf and flower development stages. It is needed for Flowering locus C (FLC, the master repressor of flowering) and FLC-like gene expression in the shoot and root apex, and for the activity of the floral repressor pathway.


Pssm-ID: 466816 [Multi-domain]  Cd Length: 389  Bit Score: 246.69  E-value: 1.60e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  15 VIIDNGTGYIKSGFAGEDIPSlVFPSYVGRPKYKRvmagaveGNIFVGNKAEEYRGL--LKVTYPINHGIIQNWNDMENI 92
Cdd:cd10210    2 LVLDNGAYTIKAGFASDDPPR-VIPNCIAKPKSER-------RRLFGDDQLDECKDLsgLFYRRPFERGYLVNWDLQRQI 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  93 WIHVYNSLKINSD--EHPILLTEAPLNPQKNKEKIAEVFFETFNVPALFISMQAILSLYSCGKTNGT----------VLD 160
Cdd:cd10210   74 WDHLFGKLLLNVDpsDTALVLTEPPFNPPSIQEAMDEIVFEEYGFQSLYRTTAAALSAFAYLADSEQssssssqcclVVD 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 161 CGDGVCHCVSIYEGYNITNTITRTDVAGRDITNYL----SFllrkngHLFNTSSEMEVVKNMKENCCYVSFN----MNKE 232
Cdd:cd10210  154 SGFSFTHIVPFFDGKPVKRAVRRIDVGGKLLTNYLkeiiSY------RQLNVMDETYLVNQIKEDLCFVSTDfyedLEIA 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 233 KNSSEKAVTTLPYILPDGS----------------------QIL-IGSERYRAPEVLFNPSILGLEYLGLSELIVTSITR 289
Cdd:cd10210  228 KKKGKENTIRRDYVLPDYTtskrgyvrdpeepnrgklkedeQVLrLNNERFTVPELLFHPSDIGIQQAGIAEAIVQSINA 307
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 290 ADMDLRKTLYSHIVLSGGTTLFQGFGDRLLNEIRKFAPKDITIRISAPPERKFSTFIGGSILASLATFKKIWISKQEFDE 369
Cdd:cd10210  308 CPEELQPLLYANIVLTGGNALFPGFRERLEAELRSLAPDDYDVNVTLPEDPITYAWEGGSLLAQSPEFEELAVTRAEYEE 387

                 ..
gi 124505713 370 YG 371
Cdd:cd10210  388 HG 389
ASKHA_NBD_AtARP7-like cd10209
nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 7 and similar ...
15-376 6.23e-64

nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 7 and similar proteins; Arabidopsis thaliana ARP7 is an essential nuclear protein, ubiquitously expressed in all cell types. It is needed for normal embryogenesis, plant architecture, and floral organ abscission. It may play a role in regulating various phases of plant development through chromatin-mediated gene regulation.


Pssm-ID: 466815 [Multi-domain]  Cd Length: 354  Bit Score: 208.01  E-value: 6.23e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  15 VIIDNGTGYIKSGFAGED-IPSLVFPSyvgrpkykrVMAGAVEGnifVGNKAEEYRGLLkvTYPINHGIIQNWNDMENIW 93
Cdd:cd10209    1 VVIDAGSRLLKAGYAYPDrEPSVVEPT---------RVTPAVED---GEESDTVVEGNT--VSPIRRGRIEDWDALEALL 66
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  94 IHV-YNSLK-INSDEHPILLTEAPLNPQKNKEKIAEVFFETFNVPALFISMQAILSLYSCGKTNGTVLDCGDGVCHCVSI 171
Cdd:cd10209   67 RYVfYTGLGwEEGNEGQVLIAEPLLTSKAERERLTQLMFETFNVSGLYASEQAVLSLYAVGRISGCVVDVGHGKIDIAPV 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 172 YEGYNITNTITRTDVAGRDITNYLSFLLRKNGHLfnTSSEMEVVKNMKENCCYV--SFNMNKEKNSSEKAVTtlpYILPD 249
Cdd:cd10209  147 WEGAIQHNAVRRFEIGGRDLTELLAAELGKSNPK--VKLDRSIVERLKEAVAWSadDEEAYEKKVLTCSPET---YTLPD 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 250 GSQILIGSERYRAPEVLFNPSILGLEYLGLSELIVTSITRADMDLRKTLYSHIVLSGGTTLFQGFGDRLLNEIR-KFAPK 328
Cdd:cd10209  222 GRVISVGKERYCVGEALFRPSILGIEEYGIVEQLVRAVSTSPSENRRQLLENIVLCGGTSSVPGLEARLQKEIRlLSSPS 301
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 124505713 329 DITIRISAP---PER--KFSTFIGGSILAslatfKKIW-----ISKQEFDEYGSVILH 376
Cdd:cd10209  302 SRPALVKPPeymPENtlRYSAWIGGAILA-----KVVFpqnqhVTKADYDETGPSVVH 354
ASKHA_NBD_Arp5 cd10211
nucleotide-binding domain (NBD) of actin-related protein5 (Arp5) and similar proteins; Arp5, ...
14-371 3.75e-60

nucleotide-binding domain (NBD) of actin-related protein5 (Arp5) and similar proteins; Arp5, also called actin-like protein 5, may act as a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. It is involved in DNA double-strand break repair and UV-damage excision repair. Human Arp5 is encoded by the ACTR5 gene. Arabidopsis thaliana ARP5 (AtARp5) is a ubiquitously expressed nuclear protein involved in DNA repair and required for multicellular development of all organs. AtARp5 may be part of other chromatin remodeling machines in addition to INO80.


Pssm-ID: 466817 [Multi-domain]  Cd Length: 345  Bit Score: 197.80  E-value: 3.75e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  14 PVIIDNGTGYIKSGFAGEDIPSLVFPSYVGRPKYKRvmAGAVEgnIFVGNKA---EEYRGLLKVtyPINHGIIQNWNDME 90
Cdd:cd10211    1 PIVIDNGSYQCRAGWAGDKEPRLVFRNLVAKPRDRK--KGITV--TLVGNDIlndEAVRSHLRS--PFDRNVVTNFDLQE 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  91 NIWIHVYNSLKINSD---EHPILLTEAPLNPQKNKEKIAEVFFETFNVPALFISMQAILSLY----SCGKTNGTVLDCGD 163
Cdd:cd10211   75 QILDYIFSHLGINSEgsvDHPIVLTEALCNPNYSRQLMSELLFECYGVPSVAYGIDSLFSYYhnqpQGDPSDGLVISSGY 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 164 GVCHCVSIYEGYNITNTITRTDVAGRDITNYLSFLLR-KNGHLFN--TSSEMEvvkNMKENCCYVSFNmnkeknssekav 240
Cdd:cd10211  155 STTHVIPVLNGRLDLSQCKRINLGGFHATDYLQRLLQlKYPTHPSaiTLSRAE---ELVHEHCYVAED------------ 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 241 ttlpYIlpdgSQILIGSERYRAPEvlfNPSILGLEYlGLSELIVTSITRADMDLRKTLYSHIVLSGGTTLFQGFGDRLLN 320
Cdd:cd10211  220 ----YD----EELKKWEDPEYYEE---NVRKIQLPF-GLVETIEFVLKRYPAEQQDRLVQNVFLTGGNALFPGLKERLEK 287
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 124505713 321 EIRKFAP--KDITIRISAPPerKFSTFIGGSILASLATFKKIWISKQEFDEYG 371
Cdd:cd10211  288 ELRAIRPfgSPFNVVRAKDP--VLDAWRGAAKWALDSTFEKVWITKQEYEEKG 338
ASKHA_NBD_ScArp9-like cd10208
nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein 9 (Arp9) and ...
13-378 1.12e-49

nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein 9 (Arp9) and similar proteins; Saccharomyces cerevisiae Arp9, also called actin-like protein 9, chromatin structure-remodeling complex protein ARP9, or SWI/SNF complex component ARP9, is a component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. It is also part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of many genes. Arp9 forms a stable heterodimer with Arp7 protein in both the RSC and SWI/SNF chromatin-remodeling complexes. It has been suggested that this dimer functions as a module with DNA bending proteins, to achieve correct architecture and facilitate complex-complex interactions. Fission yeast SWI/SNF and RSC complexes do not contain Arp7 and Arp8, but instead contain Arp9 and Arp42.


Pssm-ID: 466814  Cd Length: 356  Bit Score: 170.57  E-value: 1.12e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  13 QPVIIDNGTGYIKSGFAGED---IPSLVFPSYVGrpkykrvmagavegnifvgnkaeeyrgllkVTYPINHGIIQNWNDM 89
Cdd:cd10208    1 NILVIDPGSQTTRAGLGLGElltPPTIEIPTRVE------------------------------IIWPIQDGRVVDWDAL 50
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  90 ENIWIHVYNSL---KINSDEHPILLTEAPLNPQKNKEKIAEVFFETFNVPALFISMQAILSLYSCGKTNGTVLDCGDGVC 166
Cdd:cd10208   51 EALWRHILFSLlsiPRPTNNSPVLLSVPPSWSKSDLELLTQLFFERLNVPAFAILEAPLAALYAAGATSGIVVDIGHEKT 130
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 167 HCVSIYEGYNITNTITRTDVAGRDITNYLSFLLRKNGHLFNTSSEM------EVVKNMKEN--CCYVSFNmnkeknssek 238
Cdd:cd10208  131 DITPIVDSQVVPHALVSIPIGGQDCTAHLAQLLKSDEPELKSQAESgeeatlDLAEALKKSpiCEVLSDG---------- 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 239 avttlpYILPDGSQILIGSERYRAPEVLFNPSILGLeyLGLSELIVTSITRA---DMDLRKTLYSHIVLSGGTTLFQGFG 315
Cdd:cd10208  201 ------ADLASGTEITVGKERFRACEPLFKPSSLRV--DLLIAAIAGALVLNasdEPDKRPALWENIIIVGGGSRIRGLK 272
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 316 DRLLNEIRKF-----------APKDITI-RIsaP---PERK-----FSTFIGGSILASLAtF----KKIWISKQEFDEYG 371
Cdd:cd10208  273 EALLSELQQFhlisetsaspqQPRIIRLaKI--PdyfPEWKksgyeEAAFLGASIVAKLV-FndpsSKHYISKVDYNEKG 349

                 ....*..
gi 124505713 372 SVILHKK 378
Cdd:cd10208  350 PAAIHTK 356
ASKHA_NBD_Arp10 cd10207
nucleotide-binding domain (NBD) of actin-related protein 10 (Arp10) and similar proteins; ...
15-373 1.73e-48

nucleotide-binding domain (NBD) of actin-related protein 10 (Arp10) and similar proteins; Arp10, also known as actin-related protein 11 (Arp11), is a subunit of the cargo-binding portion of the dynein activator, dynactin. It, together with dynactin4 (p62), -5(p25), and -6(p27), forms a heterotetrameric complex located at the pointed end of Arp1. Arp1 forms a mini-filament of uniform size, with proteins bound along its length and at both ends. Human Arp10 is encoded by the ACTR10 gene.


Pssm-ID: 466813 [Multi-domain]  Cd Length: 375  Bit Score: 168.20  E-value: 1.73e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  15 VIIDNGTGYIKSGFAGEDIPSLVFPSYVGRPKYKRVmagaVEGNIFVGNKAEEYRGLLKvtypinhgiiqnwndmenIWI 94
Cdd:cd10207    1 VVLDIGSAYTKCGFAGESAPRCIIPSEVKLPGGKKV----IRVVDQRSGNEEELYEALK------------------EFL 58
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  95 H-VYNS-LKINSDEHPILLTEAPLNPQKNKEKIAEVFFETFNVPALFISMQAILSLYSCGKTNGTVLDCGDGVCHCVSIY 172
Cdd:cd10207   59 HeLYFKhLLVNPKDRRVVVVESVLCPTPFRETLAKVLFKHFEVPSVLFAPSHLLSLLTLGIRTALVVDCGYRETRVLPVY 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 173 EGYNITNTITRTDVAGRDITNYLSFLLRKNGHLFNTSSEM------------EVVKNMKENCCYVSFNMNKEKNSSEKAV 240
Cdd:cd10207  139 EGVPLLSAWQSTPLGGKALHKRLKKLLLEHATVVTGDNKGqllssvdsllseEVLEDIKVRACFVTSLERGKTLQSATEE 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 241 TTLPYILP--------DGSQILI--GSERYRAPEVLFNPSIlglEYLGLSELIVTSITRADMDLRKTLYSHIVLSGGTTL 310
Cdd:cd10207  219 GSTEEPSPpppvdyplDGEKILIvpGSIRESAEELLFEGDN---EEKSLPTLILDSLLKCPIDVRKQLAENIVVIGGTSM 295
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124505713 311 FQGFGDRLLNEIRKFAPKD--------ITIRISAPPERKFSTF---IGGSILASLATFKKIWISKQEFDEYGSV 373
Cdd:cd10207  296 LPGFKHRLLEELRALLRKPkyfeelapKTFRFHTPPSVFKPNYlawLGGSIFGALESILGRSLSREAYLQTGRI 369
ASKHA_NBD_AtArp8-like cd13396
nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 8 (AtArp8) and ...
15-367 8.51e-32

nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 8 (AtArp8) and similar proteins; Arabidopsis thaliana ARP8, also called F-box protein ARP8, is an F-Box protein localized to the nucleolus. It is ubiquitously expressed in all organs and cell types and has a cell cycle-dependent subcellular pattern of distribution: it is localized to the nucleolus in interphase cells and dispersed in the cytoplasm in mitotic cells.


Pssm-ID: 466847  Cd Length: 332  Bit Score: 122.65  E-value: 8.51e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  15 VIIDNGTGYIKSGFAGEDIPSLVFPSY-----VGRPKYKRvMAGAVEGNIFVGNKAEEyRGLLKVTYPINHgiiqnwndm 89
Cdd:cd13396    1 IIIDGGSGYCKFGWSNYASPSGRLATFlefgnIESPMYAR-LCHFVFTIMTRMQVKPS-RQPVVVSLPLCH--------- 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  90 eniwihvynslkinSDEhpillTEAPLNPQKN-KEKIAEVFFEtFNVPALFISMQAILSLYSCGKTNGTVLDCGDGVCHC 168
Cdd:cd13396   70 --------------SDD-----TESAAASRRQlRGTIFNVLFD-MNVPAVCAVDQAVLALYAANRTSGIVVNIGFRVTTI 129
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 169 VSIYEGYNITNTITRTDVAGR-DITNYLSFLLRKNGHLFNTsseMEVVKNMKENCCYVSFNMNKEKNSSEKAVTTlpyiL 247
Cdd:cd13396  130 VPVYRGRVMHDIGVEVVGQGAlRLTGFLKELMQQNGIRFPS---LYTVRTIKEKLCYVAEDYEAELAKDTQASCE----V 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 248 PDGSQILIGSERYRAPEVLFNPSILGLEYLGLSELIVTSITRADMDLR---KTLYSHIVLSGGTTLFQGFGDRLLNEIRK 324
Cdd:cd13396  203 AGEGWFTLSNERFKTGEILFQPGLGGMRAMGLHQAVALCMDHCALVHSqgdDGWFKTIVLSGGSACLPGLSERLERELRK 282
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 124505713 325 FAPKDIT--IRISAPPERKFSTFIGGSILASLATFKKIW-ISKQEF 367
Cdd:cd13396  283 LLPKSLSegIRIIPPPLGPDSAWQGAKLISNLSNFPDGWcITKKQF 328
ASKHA_NBD_Arp8-like cd10206
nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The ...
58-375 4.00e-26

nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; The Arp8-like family includes Arp8, also called actin-like protein 8, from vertebrates and fungi. Human Arp8 is encoded by the ACTR8 gene and is also known as INO80 complex subunit N. It plays an important role in the functional organization of mitotic chromosomes. Arp8 exhibits low basal ATPase activity, and is unable to polymerize. It is probably a core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication, and probably DNA repair. it is required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Arp8 strongly prefers nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex. This subfamily also contains Arabidopsis thaliana Arp9.


Pssm-ID: 466812 [Multi-domain]  Cd Length: 447  Bit Score: 108.87  E-value: 4.00e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  58 NIFVGNKA------EEYRgllkVTYPINHGIIqNWN-----------DMENIWIHVYNS-LKINSDEHP----ILLTEAP 115
Cdd:cd10206  121 DFLVGEEAlrlppsEEYN----LHWPIRRGRL-NVHsdggsltavldDLEDIWSHALEEkLEIPRKDLKnyraVLVIPDL 195
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 116 LNPQKNKEkIAEVFFETFNVPALFISMQAILSLYSCGKTNGTVLDCGDG---VChCVSiyEGYNITNTITRTDVAGRDIT 192
Cdd:cd10206  196 FDRRHVKE-LVDLLLRRLGFSSVFVHQESVCATFGAGLSSACVVDIGAQktsVA-CVE--DGLSIPNSRIRLPYGGDDIT 271
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 193 NYLSFLLRKNGHLF-----NTSSEMEVVKNMKENCCyvsfNMNKEknssekavttlpyilPDGSQILIGSERYRA-PEVL 266
Cdd:cd10206  272 RCFLWLLRRSGFPYrecnlNSPLDFLLLERLKETYC----TLDQD---------------DIGVQLHEFYVREPGqPTLK 332
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 267 FNPSILGLEylglsELIVTSITR-ADMDLRKTLYSHIVLSGGTTLFQGFGDRL---LNEIRKFAPKDI-TIRISAPPERK 341
Cdd:cd10206  333 YQFKLLPLD-----EAIVQSILScASDELKRKMYSSILLVGGGAKIPGLAEALedrLLIKIPSLFEAVeTVEVLPPPKDM 407
                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 124505713 342 ---FSTFIGGSILASLATFKKIWISKQEFDEYGSVIL 375
Cdd:cd10206  408 dpsLLAWKGGAVLACLDSAQELWITRKEWQRLGVRAL 444
ASKHA_NBD_ScArp7-like cd10212
nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein7 (Arp7) and ...
15-368 8.66e-20

nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein7 (Arp7) and similar proteins; Saccharomyces cerevisiae Arp7, also called actin-like protein 7, is a component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. It is also part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of many genes. Arp7 forms a stable heterodimer with Arp9 protein in both the RSC and SWI/SNF chromatin-remodeling complexes. It has been suggested that this dimer functions as a module with DNA bending proteins, to achieve correct architecture and facilitate complex-complex interactions. Fission yeast SWI/SNF and RSC complexes do not contain Arp7 and Arp8, but instead contain Arp9 and Arp42.


Pssm-ID: 466818 [Multi-domain]  Cd Length: 424  Bit Score: 90.16  E-value: 8.66e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  15 VIIDNGTGYIKSGFAGEDIPSLVFPS-YVgrpkyKRVMAGAVEGNIF-----VGNKAEEYRGLLKVTYPINHGIIQNWND 88
Cdd:cd10212    6 VVIHNGSHRTVAGFSNVELPQCIIPSsYI-----KRTDEGGEAEFIFgtynmIDAAAEKRNGDEVYTLVDSQGLPYNWDA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  89 MENIWIHVYNS-LKINSDEHPILLTEAPLNPQKNK---EKIAEVFFETFNVPALFISMQAILSLYSCGKTNGTVLDCGDG 164
Cdd:cd10212   81 LEMQWRYLYDTqLKVSPEELPLVITMPATNGKPDMailERYYELAFDKLNVPVFQIVIEPLAIALSMGKSSAFVIDIGAS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 165 VCHCVSIYEGYNITNTITRTDVAGR----DITNYLSFLLRKNGHLFNTSSEMEV-----------VKNMKENCCYVS--- 226
Cdd:cd10212  161 GCNVTPIIDGIVVKNAVVRSKFGGDfldfQVHERLAPLIKEENDMENMADEQKRstdvwyeastwIQQFKSTMLQVSekd 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 227 -FNMN-----------KEKNSSEKAVTTLPYILPDGSQ-------------------ILIGSERYRAPEVLFNPSILGLE 275
Cdd:cd10212  241 lFELEryykeqadiyaKQQEQLKQMDQQLQYTALTGSPnnplvqkknflfkplnktlTLDLKECYQFAEYLFKPQLISDK 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 276 YL---GLSELIVTSITRADMDLRKTLYSHIVLSGGTTLFQGFGDRLLNEIRKFAP--KDITIRISAPPERKFSTFIGGSI 350
Cdd:cd10212  321 FSpedGLGPLMAKSVKKAPEQVYSLLLTNVIITGSTSLIEGMEQRIIKELSIRFPqyKLTTFANQVMMDRKIQGWLGALT 400
                        410
                 ....*....|....*....
gi 124505713 351 LASLATFK-KIWISKQEFD 368
Cdd:cd10212  401 MANLPSWSlGKWYSKEDYE 419
syringactin NF040575
syringactin; Syringactin are close homologs of the normally eukaryotic protein actin, found in ...
313-378 1.30e-15

syringactin; Syringactin are close homologs of the normally eukaryotic protein actin, found in the plant pathogen Pseudomonas syringae and related species. This model was created, in part, to clarify that the family is real and distinct, rather than an artifact of eukaryotic contamination of bacterial genomic sequence data. As of the creation of this HMM, the family is uncharacterized.


Pssm-ID: 468549 [Multi-domain]  Cd Length: 132  Bit Score: 72.70  E-value: 1.30e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124505713 313 GFGDRLLNEIRKFAPKDITIRISAPPERKFSTFIGGSILASLATFKKIWISKQEFDEYGSVILHKK 378
Cdd:NF040575  66 GFYEKLKKSITEKAPKGALIGMTLDPKPESAAWRGAAMYAASEGFVEMAITKQEYDESGPSIVHRK 131
ASKHA_NBD_MamK cd24009
nucleotide-binding domain (NBD) of the actin-like protein MamK family; MamK, also called ...
17-327 9.99e-08

nucleotide-binding domain (NBD) of the actin-like protein MamK family; MamK, also called magnetosome cytoskeleton protein MamK, is a protein with ATPase activity which forms dynamic cytoplasmic filaments (probably with paralog MamK-like) that may organize magnetosomes into long chains running parallel to the long axis of the cell. Turnover of MamK filaments is probably promoted by MamK-like (e.g.. MamJ and/or LimJ), which provides a monomer pool. MamK forms twisted filaments in the presence of ATP or GTP. It serves to close gaps between magnetosomes in the chain. Interaction with MCP10 is involved in controlling the response to magnetic fields, possibly by controlling flagellar rotation. The MamK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466859 [Multi-domain]  Cd Length: 328  Bit Score: 52.98  E-value: 9.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  17 IDNGTGyiKSGFAGEDIPSLVFPSYVGRPKyKRVMAGAVEGNIFVGNKAEEYRGLLKVTYPINHGIIQNWNDmeniwihv 96
Cdd:cd24009    6 IDLGTS--RSAVVTSRGKRFSFRSVVGYPK-DIIARKLLGKEVLFGDEALENRLALDLRRPLEDGVIKEGDD-------- 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713  97 yNSLKINSD--EHPILLTEAPLNPQ-------------KNKEKIAEVFFETFN----VPALFismqaiLSLYSCGKTNGT 157
Cdd:cd24009   75 -RDLEAAREllQHLIELALPGPDDEiyavigvparasaENKQALLEIARELVDgvmvVSEPF------AVAYGLDRLDNS 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 158 -VLDCGDG---VCHCVSIYEGYNITNTITRtdvAGRDITNYLSFLLRKngHLFNTSSEMEVVKNMKENCCYVSFNmnkek 233
Cdd:cd24009  148 lIVDIGAGttdLCRMKGTIPTEEDQITLPK---AGDYIDEELVDLIKE--RYPEVQLTLNMARRWKEKYGFVGDA----- 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124505713 234 nsSEKAVTTLPyiLPDGSQIL-IGSERYRAPEVLFNPSIlgleylglsELIVTSITRADMDLRKTLYSHIVLSGGTTLFQ 312
Cdd:cd24009  218 --SEPVKVELP--VDGKPVTYdITEELRIACESLVPDIV---------EGIKKLIASFDPEFQEELRNNIVLAGGGSRIR 284
                        330
                 ....*....|....*
gi 124505713 313 GFGDRLLNEIRKFAP 327
Cdd:cd24009  285 GLDTYIEKALKEYGG 299
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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