|
Name |
Accession |
Description |
Interval |
E-value |
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
1-480 |
0e+00 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 769.09 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 1 MATVEKKYPYALDSEGKAKYVPVWRFTQPHMMAFHLSWICFFMSFVATFAPASLAPVIRDDLFLTKSEVGNAGVSAVCGA 80
Cdd:PLN00028 5 PDPKYSKFALPVDSEHKATEFRLFSFARPHMRAFHLSWISFFTCFVSTFAAAPLLPIIRDNLNLTKSDIGNAGIASVSGS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 81 IAARLFMGIFVDVVGPRYGAAAAMLMTAPAVFCMALVTDFSTFACVRFFIGLSLCMFVCCQFWCGTMFNVQIVGTANAIA 160
Cdd:PLN00028 85 IFSRLAMGPVCDLYGPRYGSAFLLMLTAPAVFCMSLVSSATGFIAVRFFIGFSLATFVSCQYWMSTMFNGKIVGTANGIA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 161 AGWGNMGGGACHFIMPLIYQGIKDGGVPGYQAWRWAFFVPGGIYIVTATLTLLLGIDHPSGKdYRDLKKEGTLKaKGNMW 240
Cdd:PLN00028 165 AGWGNLGGGVTQLLMPLVFPLIKDAGAPSFTAWRIAFFVPGLLHIIMGILVLTLGQDLPDGN-YRELKKSGTMP-KDSFS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 241 PVIKCGLGNYRSWILALTYGYSFGVELTVDNVIVEYLFDQFGLNLAVAGALGAIFGLMNIFSRATGGMISDLIAKPFGMR 320
Cdd:PLN00028 243 KVLRYGVTNYRTWILALTYGYSFGVELTMDNIIAEYFYDRFGLSLETAGAIAASFGLMNLFARPAGGYLSDVAARRFGMR 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 321 GRLWVLWITQTLGGIFCIIMGKVsNSLTATIVIMIIFSIFCQQACGMHFGITPFVSRRAYGVVSGLVGAGGNVGAAITQA 400
Cdd:PLN00028 323 GRLWALWIVQTLGGVFCIWLGRA-NSLGAAIVVMILFSIFVQAACGATFGIVPFVSRRSLGVISGLTGAGGNVGAVLTQL 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 401 IWFSGTatwqiNLSRPDSFVWMGVQAVALTVAVMFIWFPMWGSMFTGPREGVEEEDYYLREWSAEEVAQGLHQGSMRFAM 480
Cdd:PLN00028 402 LFFTGS-----SYSTETGISLMGVMIIACTLPVAFIHFPQWGGMFFGPSKDAVEEDYYASEWTEEEKEKGLHQGSLKFAE 476
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
34-435 |
1.53e-119 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 356.18 E-value: 1.53e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 34 FHLSWICFFMSFVATFAPASLAPVIRDDLFLTKSEVGNAGVSAVCGAIAARLFMGIFVDVVGPR-YGAAAAMLMTAPAVF 112
Cdd:cd17341 1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRrVFIASLLLLLIPLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 113 CMALVTDFSTFACVRFFIGLSLCMFVCCQFWCGTMFNVQIVGTANAIAAGWGNMGGGACHFIMPLIYQGIKDggVPGYQA 192
Cdd:cd17341 81 LALAVSSYWGLLVLGFLLGFAGANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVF--DGGFVG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 193 WRWAFFVPGGIYIVTATLTLLLGIDHPSGKDYRDlkkegtlkakgNMWPVIKCGLGNYRSWILALTYGYSFGVELTVDNV 272
Cdd:cd17341 159 WRNAFFVPGILLAIAAVLVLLFGDDLPTGKASAL-----------EFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 273 IVEYLFDQFGLNLAVAGALGAIFGLMNIFSRATGGMISDLiakpFGMRGRLWVLWITQTLGGIFCIIMGKVSN-SLTATI 351
Cdd:cd17341 228 LPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDR----FGGRRRLWWLFIVMTIGAALLSLSLPTSGtNLVLFL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 352 VIMIIFSIFCQQACGMHFGITPFVSRRAYGVVSGLVGAGGNVGAAITQAIWFSGTatwQINLSRPDSFVWMGVQAVALTV 431
Cdd:cd17341 304 ALFVALGLGAGAGNGSVFRMVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSA---LMTGSGVGAFSLFGVLAVACTL 380
|
....
gi 2082255530 432 AVMF 435
Cdd:cd17341 381 LVWL 384
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
32-395 |
2.31e-115 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 344.67 E-value: 2.31e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 32 MAFHLSWICFFMSFVATFAPASLAPV-IRDDLFLTKSEVGNAGVSAVCGAIAARLFMGIFVDVVGPRYGAAAAMLMTAPA 110
Cdd:TIGR00886 1 RNLFFSWFGFFLSFLVWFAFSPLAVFlIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 111 VFCMALVT-DFSTFACVRFFIGLSLCMFVCCQFWCGTMFNVQIVGTANAIAAGWGNMGGGACHFIMP-LIYQGIKDGGVP 188
Cdd:TIGR00886 81 CLWAGLAVqSYSVLLLIRLFIGIAGGSFASCMPWISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPpIIGSLIFGGGQP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 189 GYQAWRWAF-FVPGGIYIVTATLTLLLGIDHPSGKdyrdlKKEGTLKAKGNMWpvikcGLGNYRSWILALTYGYSFGVEL 267
Cdd:TIGR00886 161 AHLAWGWAFvIVPAGILLLPALLIFFVGADTPPGK-----PATGKLSFKEALK-----VFGNRHTWILALLYSVTFGSFL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 268 TVDNVIVEYLFDQFGLNLAVAGALGAIFGLMNIFSRATGGMISDLIAKPfgmrgRLWVLWITQTLGGIFCIIMGKVSN-S 346
Cdd:TIGR00886 231 GVSSIFAMLFKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGA-----RKLLMNFLGVAMGAFLVVLGLVSDgS 305
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 2082255530 347 LTATIVIMIIFSIFCQQACGMHFGITPFVSRRAYGVVSGLVGAGGNVGA 395
Cdd:TIGR00886 306 LAAFIVLFVALFFFAGAGNGSTFALVPHIFRRATGAVSGLIGAIGNLGG 354
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
30-397 |
7.97e-47 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 167.37 E-value: 7.97e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 30 HMMAFHLSWICFFMSFVATFAPASLAPVIRDDLFLTKSEVGNAGVSAVCGAIAARLFMGIFVDVVGPRYGAAAAMLMTAP 109
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 110 AVFCMALVTDFSTFACVRFFIGLSL-CMFVCCQFWCGTMFNVQIVGTANAIAAGWGNMGGGACHFIMPLIYQGIkdggvp 188
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGIGGgGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF------ 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 189 gyqAWRWAFFVPGGIYIVTATLTLLLGIDHPSGkdyRDLKKEGTLKAKGNMwpvikcgLGNYRSWILALTYGYSFGVELT 268
Cdd:COG2223 157 ---GWRNAFLILGILLLVVAVLAWLFLRDPPAG---AAAAAKASLRDQLEA-------LRDPRFWLLSLLYFGTFGSFIG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 269 VDNVIVEYLFDQFGLNLAVAGALGAIFGLMNIFSRATGGMISDLIakpfgmrGRLWVLWITQTLGGIFCIIMGKVSNSLT 348
Cdd:COG2223 224 FSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI-------GGRRVLLIVFALMALGLLLLALALGSLW 296
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 2082255530 349 ATIVIMIIFSIFCQQACGMHFGITP-FVSRRAYGVVSGLVGAGGNVGAAI 397
Cdd:COG2223 297 LFLVLFLLLGLALGGGNGAVFALVPdIFPTKNAGAVYGLVGAAGGLGGFL 346
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
36-437 |
1.60e-24 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 104.95 E-value: 1.60e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 36 LSWICFFMSFVATFAPASLAPVIRDDLFLTKSEVGNAGVSAVCGAIAARLFMGIFVDVVGPRYGAAAAMLMTAPAVFCMA 115
Cdd:COG2271 14 LLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 116 LVTDFSTFACVRFFIGLSL-CMFVCCQFWCGTMFNVQIVGTANAIAAGWGNMGGGACHFIMPLIYQgikdggvpgYQAWR 194
Cdd:COG2271 94 FATSFWQLLLLRFLLGLGEaGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA---------AFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 195 WAFFVPGGIYIVTATLTLllgidhpsgkdyrdlkkegtlkakgnmwpvikcglgnyrsWILALTYGYSFGVELTVDNVIV 274
Cdd:COG2271 165 AAFLILGLPGLLLALLRF----------------------------------------WLLALAYFLVYFALYGFLTWLP 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 275 EYLFDQFGLNLAVAGALGAIFGLMNIFSRATGGMISDLIakpfgMRGRLWVLWITQTLGGIFCIIMGkVSNSLTATIVIM 354
Cdd:COG2271 205 TYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRL-----GRRRKLVLAIGLLLAALALLLLA-LLPSPALAIALL 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 355 IIFSIFCQQACGMHFGITP-FVSRRAYGVVSGLVGAGGNVGAAITQAI--WFSGTATWQInlsrpdSFVWMGVQAVALTV 431
Cdd:COG2271 279 FLAGFGLGGAFGLLWALAAeLFPKKARGTASGLVNTFGFLGGALGPLLvgYLLDATGYQA------AFLLLAALALLAAL 352
|
....*.
gi 2082255530 432 AVMFIW 437
Cdd:COG2271 353 LALLLL 358
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
38-397 |
1.61e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 84.40 E-value: 1.61e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 38 WICFFMSFVATFAPASLAPVIRDDLFLTKSEVGNAGVSAVCGAIAARLFMGIFVDVVGPRYGAAAAMLMTAPAVFCMALV 117
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 118 TDFSTFACVRFFIGL-SLCMFVCCQFWCGTMFNVQIVGTANAIAAGWGNMGGgachFIMPLIYQGIKDGGVPGyqaWRWA 196
Cdd:cd06174 82 PSFWLLLLGRFLLGLgSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGG----ILGPLLGGILASSLGFG---WRAV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 197 FFVPGGIYIVTATLtLLLGIDHPSGKDYRDLKKEGTLKAKGNMWPVIKcglgNYRSWILALTYGYSFGVELTVDNVIVEY 276
Cdd:cd06174 155 FLIAAALALLAAIL-LLLVVPDPPESARAKNEEASSKSVLKLLKRVLK----NPGLWLLLLAIFLVNLAYYSFSTLLPLF 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 277 LFDQFGLNLAVAGALGAIFGLMNIFSRATGGMISDLIakpfgmRGRLWVLWITQTLGGIFCIIMGKVSNSLTATIVIMII 356
Cdd:cd06174 230 LLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRL------IGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLL 303
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 2082255530 357 FSIFCQQACGMHFGITPFVSRRAYGVVSGLVGAGGNVGAAI 397
Cdd:cd06174 304 GFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAI 344
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
38-397 |
1.40e-16 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 81.17 E-value: 1.40e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 38 WICFFMSFVATFAPASLAPVIRDDLFLTKSEVGNAGVSAVCGAIAARLFMGIFVDVVGPRYGAAAAMLMTAPAVFCMALV 117
Cdd:COG2814 16 ALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 118 TDFSTFACVRFFIGLSL-CMFVCCQFWCGTMFNVQIVGTANAIAAGWGNMGGGACHFIMPLIYQGIkdggvpgyqAWRWA 196
Cdd:COG2814 96 PSLWLLLAARFLQGLGAgALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF---------GWRWV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 197 FFVPGGIYIVTATLTLLlgidhpsgkdyrdLKKEGTLKAKGNMWPVIKCGLGNYRSWILALTYGYSFGVELTVDNVIVEY 276
Cdd:COG2814 167 FLVNAVLALLALLLLLR-------------LLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLY 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 277 LFDQFGLNLAVAGALGAIFGLMNIFSRATGGMISDLIakpfgmrGRLWVLWITQTLGGIFCIIMGKVSNSLTATIVIMII 356
Cdd:COG2814 234 LQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF-------GRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLL 306
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 2082255530 357 -FSIFCQQACGMHFGITPFvSRRAYGVVSGLVGAGGNVGAAI 397
Cdd:COG2814 307 gFGFGLLFPLLQALVAELA-PPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
36-397 |
2.03e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 80.54 E-value: 2.03e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 36 LSWICFFMSFVATFAPASLAPVIRDDLFLTKSEVGNAGVSAVCGAIAARLFMGIFVDVVGPRYGAAAAMLMTAPAVFCMA 115
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 116 LVTDFSTFACVRFFIGLSL-CMFVCCQFWCGTMFNVQIVGTANAIAAGWGNMGGGACHFIMPLIYQGIkdggvpgyqAWR 194
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAgALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF---------GWR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 195 WAFFVPGGIYIVTATLTLLLGIDHPSGkdyRDLKKEGTLKAKGNMWPVIKCglgnyRSWILALTYGYSFGVELTVDNVIV 274
Cdd:pfam07690 152 AAFLILAILSLLAAVLLLLPRPPPESK---RPKPAEEARLSLIVAWKALLR-----DPVLWLLLALLLFGFAFFGLLTYL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 275 EYLFDQFGLNLAVAGALGAIFGLMNIFSRATGGMISDliakPFGMRGRLWVLWITQTLGGIFCIIMGKVSNSLTATIVIM 354
Cdd:pfam07690 224 PLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSD----RLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALL 299
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 2082255530 355 IIFSIFCQQACGMHFGITPFVSRRAYGVVSGLVGAGGNVGAAI 397
Cdd:pfam07690 300 LLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGAL 342
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
38-401 |
4.20e-13 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 70.81 E-value: 4.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 38 WICFFMSFVATFAPASLAPVIRDDLFLTKSEVGNAGVSAVCGAIAARLFMGIFVDVVGPRYGAAAAMLMTAPAVFCMALV 117
Cdd:cd17333 2 YISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFAT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 118 TDFSTFACVRFFIGLSL-CMFVCCQFWCGTMFNvQIVGTANAIAAGWGNMGGgachFIMPLIYQGIKDGGVpgyqAWRWA 196
Cdd:cd17333 82 PSIYLFVVLMFLAGLGAgILDTGANTFVGALFE-ESSATRLNVLHGFFGLGA----LIGPLIATSLLTSEL----SWSWA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 197 FFVPGGIYIVTATLTLLLgidhpsGKDYRDLKKEgTLKAKGNMWPVIKCGLGNYRSWILALTYGYSFGVELTVDNVIVEY 276
Cdd:cd17333 153 YLIIGLIYLLLAILILLT------LFPELPSARN-PQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSY 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 277 LFDQFGLNLAVAGALGAIFGLMNIFSRATGGMISDLIAKPfgmrgrlwvlwiTQTLGGIFCIIMGKVSNSLTATIVIMII 356
Cdd:cd17333 226 LVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPH------------TLLVLSGSGALLGLLILLLAPTLVVGLV 293
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 2082255530 357 FSIFCQQACGMHF--GITPFVSR--RAYGVVSGLVGAGGNVGAAITQAI 401
Cdd:cd17333 294 ATALLGLFMAALFptILSLGISNlpYAKGKGTSVLLAAGSIGGAIIPFI 342
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
27-356 |
2.75e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 68.34 E-value: 2.75e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 27 TQPHMMAFHLSWICFFMSFVATFAPASLAPVIRDDLFLTKSEVGNAGVSAVCGAIAARLFMGIFVDVVGPRYGAAAAMLM 106
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 107 TAPAVFCMALVTDFSTFACVRFFIGLSLCMF-VCCQFWCGTMFN---VQIVGTANAIaagwgNMGGGachFIMPLIYQGI 182
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLdVAANPYVAALGPetaASRLNLLHAF-----FSLGA---LLGPLLGGLL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 183 KDGGVPgyQAWRWAFFVPGGIYIVTATLTLLLGIDHPSGKDYRDLKKEGTLKAKgnmwpvikcgLGNYRSWILALTYGYS 262
Cdd:COG0738 155 ILLGLS--LSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSL----------LKNPRLLLGGLAIFLY 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 263 FGVELTVDNVIVEYLFDQFGLNLAVAGALGAIFGLMNIFSRATGGMISDLIakpfgmrGRLWVLWITQTLGGIFCIIMGK 342
Cdd:COG0738 223 VGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF-------GPVRLLRLSALLAAVGLLLALL 295
|
330
....*....|....
gi 2082255530 343 VSNSLTATIVIMII 356
Cdd:COG0738 296 APGPWLALIGLALV 309
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
33-397 |
5.86e-12 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 67.30 E-value: 5.86e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 33 AFHLSWICFFMSFVATFAPASLAPVIRDDLFLTKSEVGNAG-VSAVCGAIAaRLFMGIFVDVVGPRYGAAAAMLMTAPAV 111
Cdd:cd17312 4 IFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGsAFLIAYAVG-KFISGFLSDRSNIRRFMSAGLLLSALAN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 112 FCMALVTDFSTFACVRFFIGLSLCM-FVCCQFWCGTMFNVQIVGTANAIAAGWGNMGGGACHFIMpliyqgikdGGVPGY 190
Cdd:cd17312 83 IFMGFSTSLWFFAVLWGLNGLFQSMgWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILA---------ASLASY 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 191 QAWRWAFFVPGGIYIVTATLTLLLGIDHPsgkdyrdlkkegtlkakgnmwPVIkcglgnyrsWILALTYGYSFGVELTVD 270
Cdd:cd17312 154 YGWRAAFLVPGIVGLVVAIILFFFLRDSP---------------------PYV---------WVLSLAYAFVYIVRYACL 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 271 NVIVEYLFDQFGLNLAVAGALGAIFGLMNIFsratGGMISDLIAKPFGMRGRLWVLWITQTLGGIFCIIMGKVSNSLTAT 350
Cdd:cd17312 204 DWGPLYLYEVKGYSLIDAGWFSSLYEVGGIA----GTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLALFWFFPHNKLLS 279
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 2082255530 351 IVIMIIFSIFCQQACGMHFGITP--FVSRRAYGVVSGLVGAGGNVGAAI 397
Cdd:cd17312 280 IVLLFLIGFFVGGPINLIGGAAAqdIGRKEAAGTATGFVGLFGYLGASL 328
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
38-395 |
2.87e-11 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 65.09 E-value: 2.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 38 WICFFMSFVATFAPASLAPVIRDDLFLTKSEVGNAGVSAVCGAIAARLFMGIFVDVVGPRYGAAAAMLMTAPAVFCMALV 117
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 118 TDFSTFACVRFFIGLSLCM-FVCCQFWCGTMFNVQIVGTANAIAAGWGNMGGGachFIMPLIYQGIKDggvpgYQAWRWA 196
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMgWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGG---LLPPLVLFGIAE-----LYSWHWV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 197 FFVPGGIYIVTATLTLLLGID--------------HPSGKDYRDLKKEGTLKAKGNMWPVikcgLGNYRSWILALTYGYS 262
Cdd:TIGR00881 153 FIVPGIIAIIVSLICFLLLRDspqscglppaeempNEEPDGDAEKKEEELTKKQIFLQYV----LLNKVLWYISLGYVFV 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 263 FGVELTVDNVIVEYLFDQFGLNLAVAGALGAIFGLMNIFSRATGGMISDLIAKpfGMRGRLWVLW---ITQTLGGIFCII 339
Cdd:TIGR00881 229 YVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFN--GRRGPLAVFFmalIIVSLLVYWLNP 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 2082255530 340 mgkVSNSLTATIVIMII-FSIFCQQAC-GMHfgITPFVSRRAYGVVSGLVGAGGNVGA 395
Cdd:TIGR00881 307 ---AANPLMDLICLFALgFLVYGPQMLiGVI--ASELAPKKAAGTAAGFVGFFAYLGG 359
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
43-398 |
4.87e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 61.10 E-value: 4.87e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 43 MSFVATFAPAsLAPVIRDDLFLTKSEVGNAGVSAVCGAIAARLFMGIFVDVVGPRYGAAAAMLMTAPAVFCMALVTDFST 122
Cdd:cd17475 8 ASLVAQGIPA-LAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 123 FACVRFFIGLslcmfvccqfWCGTM-----------FNVQIVGTANAIAAGWGNMGGGACHFIMPLIYQGIkdggvpgyq 191
Cdd:cd17475 87 LLVLLFLVGA----------GYGSVqpgggraimrwFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHY--------- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 192 AWRWAFFVPGGIYIVTATLTLLLgidhpsgkdYRDLKKEGTLKAKGN-MWPVIKCGLGNYRSWILALTYGYSFGVELTVD 270
Cdd:cd17475 148 GWRAAFVVAGLVSILAAVLFWLF---------YREPPAASAATESAStLLRSLKEVLRNRDVWLIAIAGALLVAPQFALL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 271 NVIVEYLFDQFGLNLAVAGALGAIFGLMNIFSRATGGMISDLIAkpFGMRGRLWVLWITQTLGGIFCIIMGKVSNSLTAT 350
Cdd:cd17475 219 TFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVF--GGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLL 296
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 2082255530 351 IVIMIIFSIFCQQACGMHFG-ITPFVSRRAYGVVSGLVGAGGNVGAAIT 398
Cdd:cd17475 297 VLLLILLGLFAIGWNGLYLTlVAESAGPEQAGTALGLANTINFIGIAIG 345
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
54-401 |
1.51e-08 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 56.42 E-value: 1.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 54 LAPVIRDDLFLTKSEVGNAGVSAVCGAIAARLFMGIFVDVVGPRYGAAAAMLMTAPAVFCMALVTDFSTFACVRFFIGLS 133
Cdd:cd17319 25 AAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 134 -----LCMFVCCQFWcgtmFNVQIVGTANAI---AAGWGNMGGGachfimPLIYQGIKDGGvpgyqaWRWAFFVPGGIYI 205
Cdd:cd17319 105 eagffPGAIKALAEW----FPARERGRATGLfnsGAPLGAAIGP------PLSGWLLLLFG------WRWAFIIEGLLGL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 206 VTATLTLLLGidhpsgkdyrdlkkegtlkakGNMWPVIKCGLGnyrswILALTYGYSFGVELtvdnviveYLFDQFGLNL 285
Cdd:cd17319 169 LLAVLWWFYL---------------------RQVWGLALGYFG-----INYALYGLLTWLPT--------YLKQARGFSL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 286 AVAGALGAIFGLMNIFSRATGGMISDLIAKpfgmRGRLWVLWITqTLGGIFCIIMGKVSNSLTATIVIMIIFSIFCQQAC 365
Cdd:cd17319 215 KQVGLLAAIPFLAGAIGMILGGRLSDRLLR----GARRLVIIIG-LLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAAS 289
|
330 340 350
....*....|....*....|....*....|....*..
gi 2082255530 366 GMHFGITP-FVSRRAYGVVSGLVGAGGNVGAAITQAI 401
Cdd:cd17319 290 PVFWSLPAdLLPGEAAATAGGLINSGGNLGGFVAPLL 326
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
34-214 |
1.81e-08 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 56.43 E-value: 1.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 34 FHLSWICFFMSFVATFAPAS-LAPVIRDDLFLTKSEVGNAGVSAVCGAIAARLFMGIFVDVVGPRYGAAAAMLMTAPAVF 112
Cdd:COG2223 207 FWLLSLLYFGTFGSFIGFSSwLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 113 CMALVTDFstfacVRFFIGLSLCMFVCCQFWCGTMFNV--QIVGTAN-AIAAGWGNMGGGACHFIMPLIYQGIKDGgvpg 189
Cdd:COG2223 287 LLALALGS-----LWLFLVLFLLLGLALGGGNGAVFALvpDIFPTKNaGAVYGLVGAAGGLGGFLGPLLFGALLDA---- 357
|
170 180
....*....|....*....|....*
gi 2082255530 190 YQAWRWAFFVPGGIYIVTATLTLLL 214
Cdd:COG2223 358 TGSYTAAFLVFAVLALVALVLTLLL 382
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
54-395 |
5.45e-08 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 54.94 E-value: 5.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 54 LAPVIRDDLFLTKSEVGNAGVsavCGAIA---ARLFMGIFVDVVGPRYGAAAAMLMTAPAVFCMALVtDFSTFACVRFFI 130
Cdd:cd17345 25 AQPYLIEQYGLSKTEIGLIGS---ALSIAyglSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFV-PSATSSVGLMFI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 131 GLSLCMFV------CCQFWCGTMFNVQIVGTANAIAAGWGNMGGGachFIMPLIYQGIkdgGVPGYQAWRWAFFVPGGIY 204
Cdd:cd17345 101 LLFLNGWFqgmgwpPSGRTMVHWFSKKERGTWTSIWNISHNVGGG---LVGPLAGLGL---AIFGDGWWRGAFIFPAIIA 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 205 IVTATLTLLLGIDHPSGK----------DYRDLKKEGTLKAKGNMWPVI-KCGLGNYRSWILALTYGYSFGVELTVDNVI 273
Cdd:cd17345 175 IIVAVIVLFLGKDTPESEglppieeykgDYPEEADGEEEEQELSAWEIFvKYVLKNKLLWYIAIANVFVYLVRYGILDWA 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 274 VEYLFDQFGLNLAVAGALGAIFGLMNIFSRATGGMISDLIAKpfGMRGRLWVLWITQTlggIFCIIMGKVSNSLTATIVI 353
Cdd:cd17345 255 PTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFK--GRRAPTGIIFMILV---IVALIVYWLAPNVLVDLIA 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 2082255530 354 MII--FSIFCQQacgMHFGI--TPFVSRRAYGVVSGLVGA----GGNVGA 395
Cdd:cd17345 330 LIAlgFLIYGPV---MLIGLqaLELVPKKAAGTAAGLTGLfgylGGSVLA 376
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
38-397 |
9.46e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 54.12 E-value: 9.46e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 38 WICFFMSFVATFAPASLAPVIRDDLFLTKSEVGNA-GVSAVCGAIAaRLFMGIFVDVVGPRYGAAAAMLMTAPAVFCMAL 116
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIvAAYALAQLLF-SPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 117 VTDFSTFACVRFFIGLSLCMF-VCCQFWCGTMFNVQIVGTANAIAagwgNMGGGACHFIMPLIyqgikdGGVpGYQAW-- 193
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVwPAAMALIADIAPPEERGRAMGIF----SSAIGLGFLIGPLL------GGL-LADALgy 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 194 RWAFFVPGGIYIVTATLTLLLgIDHPSGKDYRDLKKEGTLKAKGNMWpvikcgLGNYRSWILALTYGYSFGVELTVDNVI 273
Cdd:cd17325 150 RAPFLVCAALALLALVLALLL-LPEPRPPPNKRAVSAARLRSGLRLL------LRDRRLLALFLAIFVLAFAFGALEPFL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 274 VEYLFDQFGLNLAVAGALGAIFGLMNIFSRATGGMISDLIakpfgmrGRLWVLWITQTLGGIFCIIMGkVSNSLTATIVI 353
Cdd:cd17325 223 PLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI-------GRKPLILIGLLLSAVALLLLP-LATSFWLLLLL 294
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 2082255530 354 MIIFSIfcqqACGMHFG-----ITPFVSRRAYGVVSGLVGAGGNVGAAI 397
Cdd:cd17325 295 LALLGL----GLGLVFPatlalLADIVPPEGRGTAMGLFNTAFSLGMVL 339
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
41-397 |
1.63e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 53.34 E-value: 1.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 41 FFMSFVATFAPASLAPV---IRDDLFLTKSEVG-NAGVSAVCGAIAArLFMGIFVDVVGPRYGAAAAMLMTAPAVFCMAL 116
Cdd:COG2807 24 VLVALNLRPAITSVGPLlpeIRADLGLSATQAGlLTTLPLLAFGLFA-PLAPRLARRFGLERTLLLALLLLAAGLLLRSL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 117 VTDFSTFACVRFFIGLSL-CMFVCCQFWCGTMFNvQIVGTANAIAAGWGNMGGGACHFIMPLIYQGIkdggvpgyqAWRW 195
Cdd:COG2807 103 APSVALLLAGTALIGAGIaVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAAL---------GWRG 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 196 AFFVPGGIYIVTATLTLLLGIDHPSGKdyrdlKKEGTLKAKGNMWpvikcglGNYRSWILALTYGYSFGVELTVDNVIVE 275
Cdd:COG2807 173 ALAVWALLALLALLLWLPLLRRRPAAA-----AAAPAAASLRSLW-------RSPLAWLLTLFFGLQSLLYYAVVAWLPP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 276 YLFDQfGLNLAVAGALGAIFGLMNIFSRATGGMISDliakpfGMRGRLWVLWITQTLGGIFCIIMgkVSNSLTATIVIMI 355
Cdd:COG2807 241 ILRDA-GLSAATAGLLLSLFQLAGIPGSLLVPLLAD------RLGDRRPLLLLLGLLGLAGLLGL--LLAPGSLPWLWAV 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 2082255530 356 IFSIfcqqACGMHFGITP-FVSRRA-----YGVVSGLVGAGGNVGAAI 397
Cdd:COG2807 312 LLGL----GQGGLFPLALtLIGLRArtpaeAAALSGMAQSVGYLLAAL 355
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
36-361 |
6.94e-07 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 51.46 E-value: 6.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 36 LSWICFFMSFVATFAPASLAPVIRDDLFLTKSEVGNA-GVSAVCGAIAArLFMGIFVDVVGPRYGAAAAMLMTAPAVFCM 114
Cdd:cd17353 7 LGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAfTLTIVFLAISA-PFAGRLVDRGGPRKAILIGGILFGLGFILS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 115 ALVTDFSTFacvrfFIGLSLCMFVCCQFWCGTMFNVQI------VGTANAIAAGwgNMGGGACHFImPLIYQGIKDGGVP 188
Cdd:cd17353 86 AFAISLPLL-----FLGYGVLGGIGAGIGYITPVSTAVkwfpdkRGLATGIVIA--GFGLGSLIFS-PLIAYLINTVGVP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 189 gyqawrWAFFVPGGIYIVTATLTLLLGIDHPSGK--DYRDLKKEGTLKAKGNM--WPVIKCglgnYRSWILALTYGYSFG 264
Cdd:cd17353 158 ------TTFLILGIIFLIIIVIGAFLIRDPPKGWvpPGVDPLANNAENSPRDYtpREMLRT----PTFWLLWLMFFLNAT 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 265 VELTVDNVIVEYLFDQFGLNLAVAGALGAIFGLMNIFSRATGGMISDLIakpfgmrGRLWVLWITQTLGGIFCIIMGKVS 344
Cdd:cd17353 228 AGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKI-------GRKNTLSIAFLIQGVAMFLLPFIG 300
|
330
....*....|....*..
gi 2082255530 345 NSLtATIVIMIIFSIFC 361
Cdd:cd17353 301 SVA-VLFVLGVALIGFC 316
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
86-397 |
2.33e-06 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 49.96 E-value: 2.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 86 FMGIFVDVVGPRYGAAAAMLMTAPAVFCMALVTDFStfacvrffiGLSLCMFVCCQFWCGTMFNVQIVGTAN-------A 158
Cdd:cd17355 57 FVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLW---------QLYLLWGLLGGGGAGTLAAVAFATVAAwwferrrG 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 159 IAAGWGNMGGGACHFIMPLIYQGIKDGgvpgyQAWRWAFFVPGGIYIVTATLTLLLGIDHPSGKDYRDLKKEGTlkaKGN 238
Cdd:cd17355 128 LALGILTAGGGLGSLVFLPLGAALIEA-----FGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASP---ASP 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 239 MWPViKCGLGNYRSWILALTYgysFGVELTVDNVIVEY--LFDQFGLNLAVAGALGAIFGLMNIFSRATGGMISDLIAKP 316
Cdd:cd17355 200 GSTL-KEALRSASFWLLALAF---FLCGFAVVGLIVHLvpYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPR 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 317 fgmrgrlWVLWITQTLGGIFCIIMGKVSNSLTATIVIMIIFSifcqqacGMHFGITPFVS--------RRAYGVVSGLVG 388
Cdd:cd17355 276 -------RLLAASYALRALGLALLLLLPFPPLALLLFAALFG-------LGWGATVPLTAalaaryfgARSYGTLFGLVF 341
|
....*....
gi 2082255530 389 AGGNVGAAI 397
Cdd:cd17355 342 APHQLGSAL 350
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
36-407 |
2.43e-06 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 49.94 E-value: 2.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 36 LSWICFFMSFV--ATFAPASLAPvIRDDLFLTKSEVGNAGVSAVCGAIAARLFMGIFVDVVGPRYGAAAAMLMTAPAVFC 113
Cdd:cd17327 9 LLCILYFLQYLdkSNISNAAVMG-MKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 114 MALVTDFSTFACVRFFIGL-SLCMFVCCQFWCGTMFNVQIVGTANAI---AAGWGNMGGGAchfimpLIYQGIKDGGVPG 189
Cdd:cd17327 88 TAAVKNFGGLIALRFFLGLfESGVFPGFILYLGMWYKREEQAKRIAFfyaAAGLGSIFGGL------LAYGVFKILGVGG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 190 YQAWRWAFFVPGGIYIVTATLTLLLGIDHPSGKDY-----------RDLKKEGTLKAKGNMWPVIKCGLGNYRSWILALT 258
Cdd:cd17327 162 LAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFlteeekelaveRLRANQTGKGDQKFKWKQIKEAFKDPRTWLLFLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 259 YGYSFGVE--LTVDNVIVEYLFDQFGLNLAVAGALGAIFGLMNIFsraTGGMISDLIAKpfgmrgRLWVLWITQTLGGIF 336
Cdd:cd17327 242 FFCSQITNngISNFLPLILKSLGFYSLQTNLLSVPIGALGAVSLL---IAALLSDRFKK------RGLFAIFACVLALVG 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2082255530 337 CIIMGKVSNS-------LTATIVIMIIFSIFCQQACgmhfGITPFVSRRAygVVSGLVGAGGNVGAAITQAIWFSGTA 407
Cdd:cd17327 313 SIILLAAPNPpgayfaaYILGGGSYAGFPILLSWIS----SNCAGYTKRA--TVLAIMLIFYNVGNIVAPQIFRAGDA 384
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
36-219 |
6.68e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 48.33 E-value: 6.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 36 LSWICFFMSFVATFAPASLAPVI-RDDLFLTKSEVGNAGVSAVCGAIAARLFMGIFVDVVGPRYG--AAAAMLMTAPAVF 112
Cdd:COG2271 184 LLALAYFLVYFALYGFLTWLPTYlVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKlvLAIGLLLAALALL 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 113 CMALVTDFSTFACVRFFIGLSLCMFVCCQF-WCGTMFNVQIVGTANAIAAGWGNMGGGACHFIMPLIYQgikdggvpgYQ 191
Cdd:COG2271 264 LLALLPSPALAIALLFLAGFGLGGAFGLLWaLAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLD---------AT 334
|
170 180
....*....|....*....|....*...
gi 2082255530 192 AWRWAFFVPGGIYIVTATLTLLLGIDHP 219
Cdd:COG2271 335 GYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
38-397 |
1.09e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 47.54 E-value: 1.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 38 WICFFMSFVATFAPASLAPVIRDDLFLTKSEVGNAG-VSAVCGAIAArLFMGIFVDVVGPRYGAAAAMLMTAPAVFCMAL 116
Cdd:cd17324 5 ALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVsAYALGYALGA-LLLGPLSDRIERRRLLLVLLLLFILGNLLAAL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 117 VTDFSTFACVRFFIGLSLCMFVCCQF-WCGTMFNVQIVGTANAIAAGwGNMGGGAchfimpliyqgikdGGVP------G 189
Cdd:cd17324 84 APSFALLLLARALAGLAHGGFWAIAAaYAADLVPPEKRGRAIGLVFS-GLTLGLV--------------LGRPlggllgQ 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 190 YQAWRWAFFVPGGIYIVTATLTLLLGIDHPSgkdyrdlKKEGTLKAKGNMWPVIKcglgNYRSWILALTYGYSFGVELTV 269
Cdd:cd17324 149 LLGWRAAFLAIAVLALLAALLLWRLLPSLPP-------KKPGSLGLLSSLLLLLR----NPRLRLAYLITFLLFGGFFAL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 270 DNVIVEYLFDQFGLNLAVAGALGAIFGLMNIFSRATGGMISDliakpfgmRGRLWVLWITQTLGGIFCIIMGKVSNSLTA 349
Cdd:cd17324 218 YTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLAD--------RGGRRALLIALLLLAAALLLLTLLGPSPLL 289
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 2082255530 350 TIVIMIIFSIFCQqacGMHFGITPFVSR---RAYGVVSGLVGAGGNVGAAI 397
Cdd:cd17324 290 LLVGLVLWGLGFF---AAHSALQTRVLRlapEARGLASSLYLAAYNLGGAL 337
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
34-398 |
2.81e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 46.44 E-value: 2.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 34 FHLSWICFFMSFVATFAPASLAPVIR--DDLFLTKSEVGNAGVSAVCGAIAARLFMGIFVDVVGPRYGAAAAMLMTAPAV 111
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAaeFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 112 FCMALVTDFSTFACVRFFIGLSLCM-FVCCQFWCGTMFNVQIVGTANAIAAGWGNMGGGACHFIMPLIYQGIkdggvPGY 190
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGeYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLL-----SGD 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 191 QAWRWAFFVPGGIYIVTATLtlllgidhpsgkdyrdlkkegtlkakgnmwpvikcglgNYRSWILALTYGYSFGVELTVD 270
Cdd:cd17316 156 WGWRILFLIGALPALLALLL--------------------------------------RRRTLLLILLWFFISFGYYGLT 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 271 NVIVEYLFDQFGLNLAVAGALGAIFGLMNIFSRATGGMISDLIakpfgmrGRLWVLWITQTLGGIFCIIMGKV-SNSLTA 349
Cdd:cd17316 198 TFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI-------GRKKTLVIGLILSGILALPLFYLlSGSPTL 270
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 2082255530 350 TIVIMIIFSIFCQQACGMHFGITP--FVSR-RAYGVvsGLVGAGGNVGAAIT 398
Cdd:cd17316 271 LLLLLFILSFFVGGVWGALYAYLAelFPTEvRATGV--GLSYNLGRLGGGGA 320
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
253-447 |
2.96e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 42.93 E-value: 2.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 253 WILALTYGYSFGVELTVdNVIVEYLFDQFGLNLAVAGALGAIFGLMNIFSRATGGMISDLIakpfgmrGRLWVLWITQTL 332
Cdd:COG2271 13 ALLFLAYFLNYLDRSNL-SVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRF-------GRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 333 GGIFCIIMGkVSNSLTATIVIMIIFSIfcqqACGMHFG-----ITPFVSRRAYGVVSGLVGAGGNVGAAITQAI--WFSG 405
Cdd:COG2271 85 WGLATLLFG-FATSFWQLLLLRFLLGL----GEAGFFPaalklIAEWFPPKERGRALGIFNAGGPLGGALAPPLlgWLLA 159
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 2082255530 406 TATWQInlsrpdSFVWMGVqaVALTVAVMFIWFPMWGSMFTG 447
Cdd:COG2271 160 AFGWRA------AFLILGL--PGLLLALLRFWLLALAYFLVY 193
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
27-214 |
7.52e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 41.72 E-value: 7.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 27 TQPHMMAFHLSWICFFMSFVATFAPASLAPVIRDDLFLTKSEVGNAGVSAVCGAIAARLFMGIFVDVVGPRYGAAAAMLM 106
Cdd:COG0477 9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 107 TAPAVFCMALVTDFSTFACVRFFIGLSLC-MFVCCQFWCGTMFNVQIVGTANAIAAGWGNMGGgachFIMPLIyqgikDG 185
Cdd:COG0477 89 FGLASLLCGLAPSPELLIAARALQGIGAGgLMPGALALIAELFPARERGRALGLWGAAIGLGL----ALGPLL-----GG 159
|
170 180
....*....|....*....|....*....
gi 2082255530 186 GVPGYQAWRWAFFVPGGIYIVTATLTLLL 214
Cdd:COG0477 160 LLVAALGWRWIFLINAPLGLLALVLRLRL 188
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
193-391 |
7.47e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 38.76 E-value: 7.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 193 WRWAFFVPGGIYIVTATLTLLLGIDHPSGkdyrDLKKEGTLKAKGNMWPVIKCGLGNYRSWILAL---------TYGYSF 263
Cdd:cd17328 153 WRWAFRVTGVLGVLLAILLLLFVREPPRG----AAEGGVMAKSTATSFLADLKALAKNPSFILSTlgftavsfvTGALAF 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2082255530 264 gveltvdnVIVEYLFDQFGLNLAVAGALGAIFGLMNIFSRATGGMISDLIAKPFGM---RGRLWVLWITQTLGGIFCIIM 340
Cdd:cd17328 229 --------WAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRktpRADPLVCAVGLLAAAPFLFLA 300
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2082255530 341 GKVSNSLTATIVIMIIFSIFCqqACgMHFGITPFV-------SRRA-----YGVVSGLVGAGG 391
Cdd:cd17328 301 LVLALSNLLLAWVLLFLGEFL--LS-LNWAPVFAIllyvvipTRRStasaiQILLSHLLGDAG 360
|
|
| |
