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Conserved domains on  [gi|196005513|ref|XP_002112623|]
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uncharacterized protein TRIADDRAFT_56831 [Trichoplax adhaerens]

Protein Classification

RNA-binding protein; RNA-binding protein 43( domain architecture ID 10188106)

RNA-binding protein containing an RNA recognition motif (RRM)| RNA-binding protein 43 (RBM43) is an RNA-binding protein containing an RNA recognition motif (RRM)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RRM_AKAP17A cd12264
RNA recognition motif (RRM) found in A-kinase anchor protein 17A (AKAP-17A) and similar ...
139-267 8.16e-59

RNA recognition motif (RRM) found in A-kinase anchor protein 17A (AKAP-17A) and similar proteins; This subfamily corresponds to the RRM domain of AKAP-17A, also termed 721P, or splicing factor, arginine/serine-rich 17A (SFRS17A). It was originally reported as the pseudoautosomal or X inactivation escape gene 7 (XE7) and as B-lymphocyte antigen precursor. It has been suggested that AKAP-17A is an alternative splicing factor and an SR-related splicing protein that interacts with the classical SR protein ASF/SF2 and the SR-related factor ZNF265. Additional studies have indicated that AKAP-17A is a dual-specific protein kinase A anchoring protein (AKAP) that can bind both type I and type II protein kinase A (PKA) with high affinity and co-localizes with the catalytic subunit of PKA in nuclear speckles as well as the splicing factor SC35 in splicing factor compartments. It is involved in regulation of pre-mRNA splicing possibly by docking a pool of PKA in splicing factor compartments. AKAP-17A contains an RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain).


:

Pssm-ID: 409708 [Multi-domain]  Cd Length: 122  Bit Score: 189.02  E-value: 8.16e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196005513 139 GERPDTVVIDNLPCYWFMDPghhSTDHKPNQDIVMQVFSKFGTIRCLHIPLLDKYHKSAD-NPFQTFSFNNQLNFKVYIQ 217
Cdd:cd12264    1 GERPDTIHLEGLPCKWFAVP---RSSDKPSENVLRKVFEKFGKIRNVDIPMLDPYRKEMDgNGFDTFSFGGHLHFEAYVQ 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 196005513 218 YEEYQGFCLAIHQLKGMKLQYRLNrtqdgQKKEMLAKIQVDFDKTGHLNS 267
Cdd:cd12264   78 YEEYDGFVKAMDALRGMKLMYKGE-----DGKALAANIKVDFDKTKHLSE 122
PTZ00121 super family cl31754
MAEBL; Provisional
248-444 2.38e-04

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.98  E-value: 2.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196005513  248 KKEMLAKIQVDFDKTGHLNSKNIRKRRFEKLKLQQLEKEADDKAKLEQQKKEELERQRESERKRQEEERRRQQLEEEKRR 327
Cdd:PTZ00121 1590 EEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKK 1669
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196005513  328 KERYQEKRRQKNQRQQLRQQKRERLRQLQLQLQNELDQRRKNAEEklavmnlenKNRAKQLLTYllQQIANVRIEKVRKC 407
Cdd:PTZ00121 1670 AEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEE---------KKKAEELKKA--EEENKIKAEEAKKE 1738
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 196005513  408 QEEERKRKQLAGEESLRRRLINKIKKQESRKRALKRE 444
Cdd:PTZ00121 1739 AEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRK 1775
 
Name Accession Description Interval E-value
RRM_AKAP17A cd12264
RNA recognition motif (RRM) found in A-kinase anchor protein 17A (AKAP-17A) and similar ...
139-267 8.16e-59

RNA recognition motif (RRM) found in A-kinase anchor protein 17A (AKAP-17A) and similar proteins; This subfamily corresponds to the RRM domain of AKAP-17A, also termed 721P, or splicing factor, arginine/serine-rich 17A (SFRS17A). It was originally reported as the pseudoautosomal or X inactivation escape gene 7 (XE7) and as B-lymphocyte antigen precursor. It has been suggested that AKAP-17A is an alternative splicing factor and an SR-related splicing protein that interacts with the classical SR protein ASF/SF2 and the SR-related factor ZNF265. Additional studies have indicated that AKAP-17A is a dual-specific protein kinase A anchoring protein (AKAP) that can bind both type I and type II protein kinase A (PKA) with high affinity and co-localizes with the catalytic subunit of PKA in nuclear speckles as well as the splicing factor SC35 in splicing factor compartments. It is involved in regulation of pre-mRNA splicing possibly by docking a pool of PKA in splicing factor compartments. AKAP-17A contains an RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain).


Pssm-ID: 409708 [Multi-domain]  Cd Length: 122  Bit Score: 189.02  E-value: 8.16e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196005513 139 GERPDTVVIDNLPCYWFMDPghhSTDHKPNQDIVMQVFSKFGTIRCLHIPLLDKYHKSAD-NPFQTFSFNNQLNFKVYIQ 217
Cdd:cd12264    1 GERPDTIHLEGLPCKWFAVP---RSSDKPSENVLRKVFEKFGKIRNVDIPMLDPYRKEMDgNGFDTFSFGGHLHFEAYVQ 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 196005513 218 YEEYQGFCLAIHQLKGMKLQYRLNrtqdgQKKEMLAKIQVDFDKTGHLNS 267
Cdd:cd12264   78 YEEYDGFVKAMDALRGMKLMYKGE-----DGKALAANIKVDFDKTKHLSE 122
PTZ00121 PTZ00121
MAEBL; Provisional
248-444 2.38e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.98  E-value: 2.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196005513  248 KKEMLAKIQVDFDKTGHLNSKNIRKRRFEKLKLQQLEKEADDKAKLEQQKKEELERQRESERKRQEEERRRQQLEEEKRR 327
Cdd:PTZ00121 1590 EEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKK 1669
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196005513  328 KERYQEKRRQKNQRQQLRQQKRERLRQLQLQLQNELDQRRKNAEEklavmnlenKNRAKQLLTYllQQIANVRIEKVRKC 407
Cdd:PTZ00121 1670 AEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEE---------KKKAEELKKA--EEENKIKAEEAKKE 1738
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 196005513  408 QEEERKRKQLAGEESLRRRLINKIKKQESRKRALKRE 444
Cdd:PTZ00121 1739 AEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRK 1775
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
235-450 1.00e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 41.65  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196005513  235 KLQYRLNRTQDGQKKEMLAKIQVDFDKTGHLNSKNIRKRRFEKLKLQQLEKEADDKAKLEQQKKEELERQRESERKRQEE 314
Cdd:pfam17380 382 RLQMERQQKNERVRQELEAARKVKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEERAREMERVRLEEQERQQQ 461
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196005513  315 ERRRQQLEEEKRRKERYQEKRRQKNQRQQlrqqkrerlrqlqlqlqnelDQRRKNAEEKLAVMN---LENKNRAKQLLTY 391
Cdd:pfam17380 462 VERLRQQEEERKRKKLELEKEKRDRKRAE--------------------EQRRKILEKELEERKqamIEEERKRKLLEKE 521
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 196005513  392 LLQQIANVRIEKVRKCQEEERkRKQLAGEEslRRRL---INKIKKQESRKRALKREL-LCRQI 450
Cdd:pfam17380 522 MEERQKAIYEEERRREAEEER-RKQQEMEE--RRRIqeqMRKATEERSRLEAMEREReMMRQI 581
 
Name Accession Description Interval E-value
RRM_AKAP17A cd12264
RNA recognition motif (RRM) found in A-kinase anchor protein 17A (AKAP-17A) and similar ...
139-267 8.16e-59

RNA recognition motif (RRM) found in A-kinase anchor protein 17A (AKAP-17A) and similar proteins; This subfamily corresponds to the RRM domain of AKAP-17A, also termed 721P, or splicing factor, arginine/serine-rich 17A (SFRS17A). It was originally reported as the pseudoautosomal or X inactivation escape gene 7 (XE7) and as B-lymphocyte antigen precursor. It has been suggested that AKAP-17A is an alternative splicing factor and an SR-related splicing protein that interacts with the classical SR protein ASF/SF2 and the SR-related factor ZNF265. Additional studies have indicated that AKAP-17A is a dual-specific protein kinase A anchoring protein (AKAP) that can bind both type I and type II protein kinase A (PKA) with high affinity and co-localizes with the catalytic subunit of PKA in nuclear speckles as well as the splicing factor SC35 in splicing factor compartments. It is involved in regulation of pre-mRNA splicing possibly by docking a pool of PKA in splicing factor compartments. AKAP-17A contains an RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain).


Pssm-ID: 409708 [Multi-domain]  Cd Length: 122  Bit Score: 189.02  E-value: 8.16e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196005513 139 GERPDTVVIDNLPCYWFMDPghhSTDHKPNQDIVMQVFSKFGTIRCLHIPLLDKYHKSAD-NPFQTFSFNNQLNFKVYIQ 217
Cdd:cd12264    1 GERPDTIHLEGLPCKWFAVP---RSSDKPSENVLRKVFEKFGKIRNVDIPMLDPYRKEMDgNGFDTFSFGGHLHFEAYVQ 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 196005513 218 YEEYQGFCLAIHQLKGMKLQYRLNrtqdgQKKEMLAKIQVDFDKTGHLNS 267
Cdd:cd12264   78 YEEYDGFVKAMDALRGMKLMYKGE-----DGKALAANIKVDFDKTKHLSE 122
PTZ00121 PTZ00121
MAEBL; Provisional
248-444 2.38e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.98  E-value: 2.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196005513  248 KKEMLAKIQVDFDKTGHLNSKNIRKRRFEKLKLQQLEKEADDKAKLEQQKKEELERQRESERKRQEEERRRQQLEEEKRR 327
Cdd:PTZ00121 1590 EEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKK 1669
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196005513  328 KERYQEKRRQKNQRQQLRQQKRERLRQLQLQLQNELDQRRKNAEEklavmnlenKNRAKQLLTYllQQIANVRIEKVRKC 407
Cdd:PTZ00121 1670 AEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEE---------KKKAEELKKA--EEENKIKAEEAKKE 1738
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 196005513  408 QEEERKRKQLAGEESLRRRLINKIKKQESRKRALKRE 444
Cdd:PTZ00121 1739 AEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRK 1775
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
235-450 1.00e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 41.65  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196005513  235 KLQYRLNRTQDGQKKEMLAKIQVDFDKTGHLNSKNIRKRRFEKLKLQQLEKEADDKAKLEQQKKEELERQRESERKRQEE 314
Cdd:pfam17380 382 RLQMERQQKNERVRQELEAARKVKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEERAREMERVRLEEQERQQQ 461
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196005513  315 ERRRQQLEEEKRRKERYQEKRRQKNQRQQlrqqkrerlrqlqlqlqnelDQRRKNAEEKLAVMN---LENKNRAKQLLTY 391
Cdd:pfam17380 462 VERLRQQEEERKRKKLELEKEKRDRKRAE--------------------EQRRKILEKELEERKqamIEEERKRKLLEKE 521
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 196005513  392 LLQQIANVRIEKVRKCQEEERkRKQLAGEEslRRRL---INKIKKQESRKRALKREL-LCRQI 450
Cdd:pfam17380 522 MEERQKAIYEEERRREAEEER-RKQQEMEE--RRRIqeqMRKATEERSRLEAMEREReMMRQI 581
PTZ00121 PTZ00121
MAEBL; Provisional
272-445 7.52e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.97  E-value: 7.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196005513  272 KRRFEKLKLQQLEKEADDKAKLEQQKKEELERQRESERKRQEEERRRQQLEEEKRRKERYQEKRRQKNQRQQLRQQKRER 351
Cdd:PTZ00121 1545 KKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEE 1624
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 196005513  352 LRQLQLQLQNELDQRRKNAEEKLAVMNL-----ENKNRAKQLLTYllQQIANVRIEKVRKCQEEERKRKQLAGEESLRRR 426
Cdd:PTZ00121 1625 LKKAEEEKKKVEQLKKKEAEEKKKAEELkkaeeENKIKAAEEAKK--AEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAK 1702
                         170
                  ....*....|....*....
gi 196005513  427 LINKIKKQESRKRALKREL 445
Cdd:PTZ00121 1703 KAEELKKKEAEEKKKAEEL 1721
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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