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Conserved domains on  [gi|221060102|ref|XP_002260696|]
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Plasmodium exported protein (PHIST), unknown function [Plasmodium knowlesi strain H]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRESAN pfam09687
Plasmodium RESA N-terminal; The short, four-helical domain first identified in the Plasmodium ...
 377-501 4.05e-20

Plasmodium RESA N-terminal; The short, four-helical domain first identified in the Plasmodium export proteins PHISTa and PHISTc has been extended to become this six-helical PRESAN domain identified in the P. falciparum-specific RESA-type (Ring-infected erythrocyte surface antigen) proteins in association with the DnaJ domain. Overall, at least 67 proteins have been detected in P. falciparum with complete copies of the PRESAN domain. No versions of this domain were detected in other apicomplexan genera, suggesting that the domain was 'invented' after the divergence of the lineage leading to the genus Plasmodium undergoing a dramatic proliferation only in P. falciparum. A secondary structure-prediction derived from the multiple alignment of the PRESAN family reveals that it is composed of an all-helical fold with six conserved helical segments. There is some evidence it might localize to membranes.


:

Pssm-ID: 430754  Cd Length: 125  Bit Score: 86.18  E-value: 4.05e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221060102  377 EITEYDLKLKIEKLPYVVKPKDMFIIWHYVQSFGRDEYLRMNGDLLRICGEVQKEYNIADHIKRREWQEASRYMISELQK 456
Cdd:pfam09687   1 NLTEEEINKKINSLNEVVSKKDMYIIWNYVNKNEKKKYYNMIEKLWKYFEELAKKYNIPEEYKKKLWKECYKEITKELKK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 221060102  457 KEHNDYLEFKELVEKGPCKKGKFYEYIDKKRNSWKFMTAVMMDSW 501
Cdd:pfam09687  81 KEKFYNKDFYSFLNKGKLSRDEFKEFINSCRKSWKKLRKELEKKW 125
PRK15196 super family cl33106
type III secretion system effector PipB2;
122-319 9.59e-11

type III secretion system effector PipB2;


The actual alignment was detected with superfamily member PRK15196:

Pssm-ID: 185118 [Multi-domain]  Cd Length: 350  Bit Score: 63.49  E-value: 9.59e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221060102 122 LRKYKKNFYQR----MEESLKQVGPD---PLPTCMKKDDKTS-------------------TVKKGMHSVQAEKTIQKGE 175
Cdd:PRK15196  46 IRRRNETQYQElietMAETLKSTMPDrgaPLPENIILDDMDGcrvefnlpgenneagqvivRVSKGDHSETREIPLASFE 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221060102 176 -------------IPKRSM----QKGGDINGKTMNGINMNGRTMNGKAMNGINVNGKTM-----NGINVNGKNMNGKNMN 233
Cdd:PRK15196 126 kicrallfrcefsLPQDSViltaQGGMNLKGAVLTGANLTAENLCDADLSGANLEGAVLfmadcEGANFKGANLSGTSLG 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221060102 234 GINMNGKTMNGKAMNGKTMNGKAMNGKTMN-----GKTMNGINVNGKNMNGKNMNGKTMNGKTMNGKTMNGKSKKEKNGK 308
Cdd:PRK15196 206 DSNFKNACLEDSIMCGATLDHANLTGANLQhasllGCSMIECNCSGANMDHTNLSGATLIRADMSGATLQGATIMAAIME 285

                        250
                 ....*....|.
gi 221060102 309 NRIMTTAELKK 319
Cdd:PRK15196 286 GAVLTRANLRK 296
 
Name Accession Description Interval E-value
PRESAN pfam09687
Plasmodium RESA N-terminal; The short, four-helical domain first identified in the Plasmodium ...
 377-501 4.05e-20

Plasmodium RESA N-terminal; The short, four-helical domain first identified in the Plasmodium export proteins PHISTa and PHISTc has been extended to become this six-helical PRESAN domain identified in the P. falciparum-specific RESA-type (Ring-infected erythrocyte surface antigen) proteins in association with the DnaJ domain. Overall, at least 67 proteins have been detected in P. falciparum with complete copies of the PRESAN domain. No versions of this domain were detected in other apicomplexan genera, suggesting that the domain was 'invented' after the divergence of the lineage leading to the genus Plasmodium undergoing a dramatic proliferation only in P. falciparum. A secondary structure-prediction derived from the multiple alignment of the PRESAN family reveals that it is composed of an all-helical fold with six conserved helical segments. There is some evidence it might localize to membranes.


Pssm-ID: 430754  Cd Length: 125  Bit Score: 86.18  E-value: 4.05e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221060102  377 EITEYDLKLKIEKLPYVVKPKDMFIIWHYVQSFGRDEYLRMNGDLLRICGEVQKEYNIADHIKRREWQEASRYMISELQK 456
Cdd:pfam09687   1 NLTEEEINKKINSLNEVVSKKDMYIIWNYVNKNEKKKYYNMIEKLWKYFEELAKKYNIPEEYKKKLWKECYKEITKELKK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 221060102  457 KEHNDYLEFKELVEKGPCKKGKFYEYIDKKRNSWKFMTAVMMDSW 501
Cdd:pfam09687  81 KEKFYNKDFYSFLNKGKLSRDEFKEFINSCRKSWKKLRKELEKKW 125
PRK15196 PRK15196
type III secretion system effector PipB2;
122-319 9.59e-11

type III secretion system effector PipB2;


Pssm-ID: 185118 [Multi-domain]  Cd Length: 350  Bit Score: 63.49  E-value: 9.59e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221060102 122 LRKYKKNFYQR----MEESLKQVGPD---PLPTCMKKDDKTS-------------------TVKKGMHSVQAEKTIQKGE 175
Cdd:PRK15196  46 IRRRNETQYQElietMAETLKSTMPDrgaPLPENIILDDMDGcrvefnlpgenneagqvivRVSKGDHSETREIPLASFE 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221060102 176 -------------IPKRSM----QKGGDINGKTMNGINMNGRTMNGKAMNGINVNGKTM-----NGINVNGKNMNGKNMN 233
Cdd:PRK15196 126 kicrallfrcefsLPQDSViltaQGGMNLKGAVLTGANLTAENLCDADLSGANLEGAVLfmadcEGANFKGANLSGTSLG 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221060102 234 GINMNGKTMNGKAMNGKTMNGKAMNGKTMN-----GKTMNGINVNGKNMNGKNMNGKTMNGKTMNGKTMNGKSKKEKNGK 308
Cdd:PRK15196 206 DSNFKNACLEDSIMCGATLDHANLTGANLQhasllGCSMIECNCSGANMDHTNLSGATLIRADMSGATLQGATIMAAIME 285

                        250
                 ....*....|.
gi 221060102 309 NRIMTTAELKK 319
Cdd:PRK15196 286 GAVLTRANLRK 296
P_fal_TIGR01639 TIGR01639
Plasmodium falciparum uncharacterized domain TIGR01639; This model represents a conserved ...
 372-427 5.38e-04

Plasmodium falciparum uncharacterized domain TIGR01639; This model represents a conserved sequence region of about 60 amino acids found in over 40 predicted proteins of Plasmodium falciparum. It is not found elsewhere, including closely related species such as Plasmodium yoelii. No member of this family is characterized.


Pssm-ID: 130700  Cd Length: 61  Bit Score: 38.39  E-value: 5.38e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 221060102  372 KDIAEEITEYDLKLKIEKLPYVVKPKDMFIIWHYVQSFGRDEYLRMNGDLLRICGE 427
Cdd:TIGR01639   4 NDLSKKLTKEELNEMINSLDEIPNRNDMLIIWNQVHGIERDKFVKMQENLKEYIQK 59
 
Name Accession Description Interval E-value
PRESAN pfam09687
Plasmodium RESA N-terminal; The short, four-helical domain first identified in the Plasmodium ...
 377-501 4.05e-20

Plasmodium RESA N-terminal; The short, four-helical domain first identified in the Plasmodium export proteins PHISTa and PHISTc has been extended to become this six-helical PRESAN domain identified in the P. falciparum-specific RESA-type (Ring-infected erythrocyte surface antigen) proteins in association with the DnaJ domain. Overall, at least 67 proteins have been detected in P. falciparum with complete copies of the PRESAN domain. No versions of this domain were detected in other apicomplexan genera, suggesting that the domain was 'invented' after the divergence of the lineage leading to the genus Plasmodium undergoing a dramatic proliferation only in P. falciparum. A secondary structure-prediction derived from the multiple alignment of the PRESAN family reveals that it is composed of an all-helical fold with six conserved helical segments. There is some evidence it might localize to membranes.


Pssm-ID: 430754  Cd Length: 125  Bit Score: 86.18  E-value: 4.05e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221060102  377 EITEYDLKLKIEKLPYVVKPKDMFIIWHYVQSFGRDEYLRMNGDLLRICGEVQKEYNIADHIKRREWQEASRYMISELQK 456
Cdd:pfam09687   1 NLTEEEINKKINSLNEVVSKKDMYIIWNYVNKNEKKKYYNMIEKLWKYFEELAKKYNIPEEYKKKLWKECYKEITKELKK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 221060102  457 KEHNDYLEFKELVEKGPCKKGKFYEYIDKKRNSWKFMTAVMMDSW 501
Cdd:pfam09687  81 KEKFYNKDFYSFLNKGKLSRDEFKEFINSCRKSWKKLRKELEKKW 125
PRK15196 PRK15196
type III secretion system effector PipB2;
122-319 9.59e-11

type III secretion system effector PipB2;


Pssm-ID: 185118 [Multi-domain]  Cd Length: 350  Bit Score: 63.49  E-value: 9.59e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221060102 122 LRKYKKNFYQR----MEESLKQVGPD---PLPTCMKKDDKTS-------------------TVKKGMHSVQAEKTIQKGE 175
Cdd:PRK15196  46 IRRRNETQYQElietMAETLKSTMPDrgaPLPENIILDDMDGcrvefnlpgenneagqvivRVSKGDHSETREIPLASFE 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221060102 176 -------------IPKRSM----QKGGDINGKTMNGINMNGRTMNGKAMNGINVNGKTM-----NGINVNGKNMNGKNMN 233
Cdd:PRK15196 126 kicrallfrcefsLPQDSViltaQGGMNLKGAVLTGANLTAENLCDADLSGANLEGAVLfmadcEGANFKGANLSGTSLG 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221060102 234 GINMNGKTMNGKAMNGKTMNGKAMNGKTMN-----GKTMNGINVNGKNMNGKNMNGKTMNGKTMNGKTMNGKSKKEKNGK 308
Cdd:PRK15196 206 DSNFKNACLEDSIMCGATLDHANLTGANLQhasllGCSMIECNCSGANMDHTNLSGATLIRADMSGATLQGATIMAAIME 285

                        250
                 ....*....|.
gi 221060102 309 NRIMTTAELKK 319
Cdd:PRK15196 286 GAVLTRANLRK 296
PRK15197 PRK15197
type III secretion system effector PipB;
184-274 4.21e-06

type III secretion system effector PipB;


Pssm-ID: 185119 [Multi-domain]  Cd Length: 291  Bit Score: 48.39  E-value: 4.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221060102 184 GGDINGKTMNGINMNGRTMNGKAMNGINVNGKTMNGINVNGKNMNGKNMNGINMNGKTMNGKAMNGKTMNGKAMNGKTM- 262
Cdd:PRK15197 178 NADFRETTLSNVNLVGANLCCANLHAVNLMGSNMTKANLTHADLTCANMSGVNLTAAILFGSDLTDTKLNGAKLDKIALt 257

                         90
                 ....*....|..
gi 221060102 263 NGKTMNGINVNG 274
Cdd:PRK15197 258 LAKALTGADLTG 269
PRK15196 PRK15196
type III secretion system effector PipB2;
183-293 7.64e-06

type III secretion system effector PipB2;


Pssm-ID: 185118 [Multi-domain]  Cd Length: 350  Bit Score: 48.08  E-value: 7.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221060102 183 KGGDINGKTMNGIN----------MNGRTMNGKAMNGINVNGKTMNGINVNGKNMNGKNMNGINMNGKTMNGKAMNGKTM 252
Cdd:PRK15196 195 KGANLSGTSLGDSNfknacledsiMCGATLDHANLTGANLQHASLLGCSMIECNCSGANMDHTNLSGATLIRADMSGATL 274

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 221060102 253 NGKAMNGKTMNGKTMNGINVNGKNMNGKNMNGKTMNGKTMN 293
Cdd:PRK15196 275 QGATIMAAIMEGAVLTRANLRKASFISTNLDGADLAEANLN 315
PRK15197 PRK15197
type III secretion system effector PipB;
186-299 3.85e-05

type III secretion system effector PipB;


Pssm-ID: 185119 [Multi-domain]  Cd Length: 291  Bit Score: 45.69  E-value: 3.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221060102 186 DINGKTMNGINmngrtmngkaMNGINVNGKTMNGINVNGKNMNGKNMNGINMNGKTMNGKAMNGKTMNGKAMNGKTMNGK 265
Cdd:PRK15197 165 DFQGEDLSDID----------ASNADFRETTLSNVNLVGANLCCANLHAVNLMGSNMTKANLTHADLTCANMSGVNLTAA 234

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 221060102 266 TMNGINVNGKNMNGKNMNGKTM-NGKTMNGKTMNG 299
Cdd:PRK15197 235 ILFGSDLTDTKLNGAKLDKIALtLAKALTGADLTG 269
PRK15197 PRK15197
type III secretion system effector PipB;
192-299 8.67e-05

type III secretion system effector PipB;


Pssm-ID: 185119 [Multi-domain]  Cd Length: 291  Bit Score: 44.53  E-value: 8.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221060102 192 MNGINMNGRTMNGKAMNGINVNGKTMNGINVNGKNMNGKNMNGINMNGKTMNGKAMNGKTMNGKAMNGKTMNGKTMNGIN 271
Cdd:PRK15197 156 LRGVNLAHKDFQGEDLSDIDASNADFRETTLSNVNLVGANLCCANLHAVNLMGSNMTKANLTHADLTCANMSGVNLTAAI 235

                         90       100
                 ....*....|....*....|....*....
gi 221060102 272 VNGKNMNGKNMNGKTMNGKTM-NGKTMNG 299
Cdd:PRK15197 236 LFGSDLTDTKLNGAKLDKIALtLAKALTG 264
PRK15196 PRK15196
type III secretion system effector PipB2;
184-309 2.50e-04

type III secretion system effector PipB2;


Pssm-ID: 185118 [Multi-domain]  Cd Length: 350  Bit Score: 43.46  E-value: 2.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221060102 184 GGDINGKTM-----NGINMNGRTMNGKAMNGINVN----------GKTMNGINVNGKNMNGKNMNGINMNGKTMNGKAMN 248
Cdd:PRK15196 176 GANLEGAVLfmadcEGANFKGANLSGTSLGDSNFKnacledsimcGATLDHANLTGANLQHASLLGCSMIECNCSGANMD 255

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221060102 249 GKTMNGKAMNGKTMNGKTMNGINVNGKNMNGKNMNGKTMNGKTMNGKTMNGKSKKEKNGKN 309
Cdd:PRK15196 256 HTNLSGATLIRADMSGATLQGATIMAAIMEGAVLTRANLRKASFISTNLDGADLAEANLNN 316
PRK15196 PRK15196
type III secretion system effector PipB2;
180-302 3.72e-04

type III secretion system effector PipB2;


Pssm-ID: 185118 [Multi-domain]  Cd Length: 350  Bit Score: 42.69  E-value: 3.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221060102 180 SMQKGGDINGKTMNGINMNGRTMNGKAMNGINVNGKTMNGINVNGKNMNGKNMNGINMNGKTMNGKAMNGKTMNGKAMNG 259
Cdd:PRK15196 217 SIMCGATLDHANLTGANLQHASLLGCSMIECNCSGANMDHTNLSGATLIRADMSGATLQGATIMAAIMEGAVLTRANLRK 296

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 221060102 260 KTMNGKTMNGINVNGKNMNGKNMNGKTMNGKTMNGKTMNGKSK 302
Cdd:PRK15196 297 ASFISTNLDGADLAEANLNNTCFKDCTLTHLRTEDATMSTSTQ 339
P_fal_TIGR01639 TIGR01639
Plasmodium falciparum uncharacterized domain TIGR01639; This model represents a conserved ...
 372-427 5.38e-04

Plasmodium falciparum uncharacterized domain TIGR01639; This model represents a conserved sequence region of about 60 amino acids found in over 40 predicted proteins of Plasmodium falciparum. It is not found elsewhere, including closely related species such as Plasmodium yoelii. No member of this family is characterized.


Pssm-ID: 130700  Cd Length: 61  Bit Score: 38.39  E-value: 5.38e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 221060102  372 KDIAEEITEYDLKLKIEKLPYVVKPKDMFIIWHYVQSFGRDEYLRMNGDLLRICGE 427
Cdd:TIGR01639   4 NDLSKKLTKEELNEMINSLDEIPNRNDMLIIWNQVHGIERDKFVKMQENLKEYIQK 59
PHA02515 PHA02515
hypothetical protein; Provisional
 188-293 9.70e-04

hypothetical protein; Provisional


Pssm-ID: 107197 [Multi-domain]  Cd Length: 508  Bit Score: 41.69  E-value: 9.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221060102 188 NGKTMNGINMNgrtMNGKAMNGINVNGKTMNGINVNGKNMNGKNMNGINMNGKTMNGKAMNGKTMNGKAMNGKTMNGKTM 267
Cdd:PHA02515 279 NINTVAGANAN---VNTVASNILDVGTVAGNIDDVQAVAGNAANINVVADNADNINATAANQANINAAVGNADNINAAVA 355

                         90       100
                 ....*....|....*....|....*.
gi 221060102 268 NGINVNGKNMNGKNMNGKTMNGKTMN 293
Cdd:PHA02515 356 NQANINAVVGNANNINAVAANEGNVN 381
PRK15197 PRK15197
type III secretion system effector PipB;
183-294 1.24e-03

type III secretion system effector PipB;


Pssm-ID: 185119 [Multi-domain]  Cd Length: 291  Bit Score: 41.07  E-value: 1.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221060102 183 KGGDINGKTMNGINMNGRTMNGKAMNGINVNGKTMNGINVNGKNMNGKNMNGINMNGKTMNGKAMNGKTMNGKAMNGKTM 262
Cdd:PRK15197 157 RGVNLAHKDFQGEDLSDIDASNADFRETTLSNVNLVGANLCCANLHAVNLMGSNMTKANLTHADLTCANMSGVNLTAAIL 236

                         90       100       110
                 ....*....|....*....|....*....|...
gi 221060102 263 NGKTMNGINVNGKNMNGKNM-NGKTMNGKTMNG 294
Cdd:PRK15197 237 FGSDLTDTKLNGAKLDKIALtLAKALTGADLTG 269
PHA02515 PHA02515
hypothetical protein; Provisional
 184-298 1.62e-03

hypothetical protein; Provisional


Pssm-ID: 107197 [Multi-domain]  Cd Length: 508  Bit Score: 40.92  E-value: 1.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221060102 184 GGDIngKTMNGINMNGRTMNGKAMNGINVNGKTMNGINVNGKNMNGKNMNGINMNGKTMNGKAMNGKTMNGKAMNGKTMN 263
Cdd:PHA02515 264 AGDL--ENIDAVADNAANINTVAGANANVNTVASNILDVGTVAGNIDDVQAVAGNAANINVVADNADNINATAANQANIN 341

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 221060102 264 GKTMNGINVNGKNMNGKNMNGKTMNGKTMNGKTMN 298
Cdd:PHA02515 342 AAVGNADNINAAVANQANINAVVGNANNINAVAAN 376
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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