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Conserved domains on  [gi|242021266|ref|XP_002431066|]
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apolipophorin-III, putative [Pediculus humanus corporis]

Protein Classification

Tim44 domain-containing protein( domain architecture ID 10194944)

Tim44 domain-containing protein similar to mitochondrial 39S ribosomal protein L45 and to mitochondrial import inner membrane translocase subunit Tim44, an essential component of the eukaryotic PAM complex which is required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ApoLp-III_like cd13769
Apolipophorin-III and similar insect proteins; Exchangeable apolipoproteins play vital roles ...
 27-191 7.97e-38

Apolipophorin-III and similar insect proteins; Exchangeable apolipoproteins play vital roles in the transport of lipids and lipoprotein metabolism. Apolipophorin III (apoLp-III) assists in the loading of diacylglycerol, generated from triacylglycerol stores in the fat body through the action of adipokinetic hormone, into lipophorin, the hemolymph lipoprotein. ApoLp-III increases the lipid carrying capacity of lipophorin by covering the expanding hydrophobic surface resulting from diacylglycerol uptake. It plays a critical role in the transport of lipids during insect flight, and may also play a role in defense mechanisms and innate immunity.


:

Pssm-ID: 259842 [Multi-domain]  Cd Length: 158  Bit Score: 128.21  E-value: 7.97e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242021266  27 TVFKDDVAKAVEKAKEFGEHITKMLGLdslPSGNEVVELIKTQAKNFADQAEQVQHQFDDELKRLTNStVAESFSEFNKK 106
Cdd:cd13769    1 TQLSELIQKAQEAINNLAQQVQKQLGL---QNPEEVVNTLKEQSDNFANNLQEVSSSLKEEAKKKQGE-VEEAWNEFKTK 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242021266 107 VQETVASFRSQLEssgMVEKASELQGKFQTGLTALFEESKKLASDLEPQMVGAGAELENLTKKVLNEAVESLNQLQTQLH 186
Cdd:cd13769   77 LSETVPELRKSLP---VEEKAQELQAKLQSGLQTLVTESQKLAKAISENSQKAQEELQKATKQAYDIAVEAAQNLQNQLQ 153


                 ....*
gi 242021266 187 TVTGH 191
Cdd:cd13769  154 TATQK 158
 
Name Accession Description Interval E-value
ApoLp-III_like cd13769
Apolipophorin-III and similar insect proteins; Exchangeable apolipoproteins play vital roles ...
 27-191 7.97e-38

Apolipophorin-III and similar insect proteins; Exchangeable apolipoproteins play vital roles in the transport of lipids and lipoprotein metabolism. Apolipophorin III (apoLp-III) assists in the loading of diacylglycerol, generated from triacylglycerol stores in the fat body through the action of adipokinetic hormone, into lipophorin, the hemolymph lipoprotein. ApoLp-III increases the lipid carrying capacity of lipophorin by covering the expanding hydrophobic surface resulting from diacylglycerol uptake. It plays a critical role in the transport of lipids during insect flight, and may also play a role in defense mechanisms and innate immunity.


Pssm-ID: 259842 [Multi-domain]  Cd Length: 158  Bit Score: 128.21  E-value: 7.97e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242021266  27 TVFKDDVAKAVEKAKEFGEHITKMLGLdslPSGNEVVELIKTQAKNFADQAEQVQHQFDDELKRLTNStVAESFSEFNKK 106
Cdd:cd13769    1 TQLSELIQKAQEAINNLAQQVQKQLGL---QNPEEVVNTLKEQSDNFANNLQEVSSSLKEEAKKKQGE-VEEAWNEFKTK 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242021266 107 VQETVASFRSQLEssgMVEKASELQGKFQTGLTALFEESKKLASDLEPQMVGAGAELENLTKKVLNEAVESLNQLQTQLH 186
Cdd:cd13769   77 LSETVPELRKSLP---VEEKAQELQAKLQSGLQTLVTESQKLAKAISENSQKAQEELQKATKQAYDIAVEAAQNLQNQLQ 153


                 ....*
gi 242021266 187 TVTGH 191
Cdd:cd13769  154 TATQK 158
ApoLp-III pfam07464
Apolipophorin-III precursor (apoLp-III); This family consists of several insect ...
 39-187 1.76e-35

Apolipophorin-III precursor (apoLp-III); This family consists of several insect apolipoprotein-III sequences. Exchangeable apolipoproteins constitute a functionally important family of proteins that play critical roles in lipid transport and lipoprotein metabolism. Apolipophorin III (apoLp-III) is a prototypical exchangeable apolipoprotein found in many insect species that functions in transport of diacylglycerol (DAG) from the fat body lipid storage depot to flight muscles in the adult life stage.


Pssm-ID: 462172 [Multi-domain]  Cd Length: 143  Bit Score: 121.71  E-value: 1.76e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242021266   39 KAKEFGEHITKMLGLdslPSGNEVVELIKTQAKNFADQAEQVQHQFDDELKRlTNSTVAESFSEFNKKVQETVASFRSql 118
Cdd:pfam07464   1 AAEELQQSVQKQLGL---PSQQEVVETIKENTENLVDQLKQVQKSLQEELKK-ASGEAEEALKELNTKIVETADKLSE-- 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 242021266  119 ESSGMVEKASELQGKFQTGLTALFEESKKLASDLEPQMVGAGAELENLTKKVLNEAVESLNQLQTQLHT 187
Cdd:pfam07464  75 ANPEVVQKANELQEKFQSGVQSLVTESQKLAKSISENSQGATEKLQKATKQAYDDAVQAAQKLANQLQP 143
 
Name Accession Description Interval E-value
ApoLp-III_like cd13769
Apolipophorin-III and similar insect proteins; Exchangeable apolipoproteins play vital roles ...
 27-191 7.97e-38

Apolipophorin-III and similar insect proteins; Exchangeable apolipoproteins play vital roles in the transport of lipids and lipoprotein metabolism. Apolipophorin III (apoLp-III) assists in the loading of diacylglycerol, generated from triacylglycerol stores in the fat body through the action of adipokinetic hormone, into lipophorin, the hemolymph lipoprotein. ApoLp-III increases the lipid carrying capacity of lipophorin by covering the expanding hydrophobic surface resulting from diacylglycerol uptake. It plays a critical role in the transport of lipids during insect flight, and may also play a role in defense mechanisms and innate immunity.


Pssm-ID: 259842 [Multi-domain]  Cd Length: 158  Bit Score: 128.21  E-value: 7.97e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242021266  27 TVFKDDVAKAVEKAKEFGEHITKMLGLdslPSGNEVVELIKTQAKNFADQAEQVQHQFDDELKRLTNStVAESFSEFNKK 106
Cdd:cd13769    1 TQLSELIQKAQEAINNLAQQVQKQLGL---QNPEEVVNTLKEQSDNFANNLQEVSSSLKEEAKKKQGE-VEEAWNEFKTK 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242021266 107 VQETVASFRSQLEssgMVEKASELQGKFQTGLTALFEESKKLASDLEPQMVGAGAELENLTKKVLNEAVESLNQLQTQLH 186
Cdd:cd13769   77 LSETVPELRKSLP---VEEKAQELQAKLQSGLQTLVTESQKLAKAISENSQKAQEELQKATKQAYDIAVEAAQNLQNQLQ 153


                 ....*
gi 242021266 187 TVTGH 191
Cdd:cd13769  154 TATQK 158
ApoLp-III pfam07464
Apolipophorin-III precursor (apoLp-III); This family consists of several insect ...
 39-187 1.76e-35

Apolipophorin-III precursor (apoLp-III); This family consists of several insect apolipoprotein-III sequences. Exchangeable apolipoproteins constitute a functionally important family of proteins that play critical roles in lipid transport and lipoprotein metabolism. Apolipophorin III (apoLp-III) is a prototypical exchangeable apolipoprotein found in many insect species that functions in transport of diacylglycerol (DAG) from the fat body lipid storage depot to flight muscles in the adult life stage.


Pssm-ID: 462172 [Multi-domain]  Cd Length: 143  Bit Score: 121.71  E-value: 1.76e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242021266   39 KAKEFGEHITKMLGLdslPSGNEVVELIKTQAKNFADQAEQVQHQFDDELKRlTNSTVAESFSEFNKKVQETVASFRSql 118
Cdd:pfam07464   1 AAEELQQSVQKQLGL---PSQQEVVETIKENTENLVDQLKQVQKSLQEELKK-ASGEAEEALKELNTKIVETADKLSE-- 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 242021266  119 ESSGMVEKASELQGKFQTGLTALFEESKKLASDLEPQMVGAGAELENLTKKVLNEAVESLNQLQTQLHT 187
Cdd:pfam07464  75 ANPEVVQKANELQEKFQSGVQSLVTESQKLAKSISENSQGATEKLQKATKQAYDDAVQAAQKLANQLQP 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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