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Conserved domains on  [gi|254574430|ref|XP_002494324|]
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uncharacterized protein PAS_chr4_0875 [Komagataella phaffii GS115]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
WD40 super family cl43672
WD40 repeat [General function prediction only];
46-115 9.42e-05

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.52  E-value: 9.42e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254574430  46 LVSADENGWVVWWDLGTKRPLGTWRAHESTIVTVQqmgihWDADvpqlhrntfGKLL-THGRDNCVRIWDL 115
Cdd:COG2319  177 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA-----FSPD---------GKLLaSGSADGTVRLWDL 233
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
46-115 9.42e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.52  E-value: 9.42e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254574430  46 LVSADENGWVVWWDLGTKRPLGTWRAHESTIVTVQqmgihWDADvpqlhrntfGKLL-THGRDNCVRIWDL 115
Cdd:COG2319  177 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA-----FSPD---------GKLLaSGSADGTVRLWDL 233
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
46-114 1.49e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.40  E-value: 1.49e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254574430  46 LVSADENGWVVWWDLGTKRPLGTWRAHESTIVTVQqmgihWDADVPQlhrntfgkLLTHGRDNCVRIWD 114
Cdd:cd00200  234 LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLA-----WSPDGKR--------LASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
46-115 9.42e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.52  E-value: 9.42e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254574430  46 LVSADENGWVVWWDLGTKRPLGTWRAHESTIVTVQqmgihWDADvpqlhrntfGKLL-THGRDNCVRIWDL 115
Cdd:COG2319  177 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA-----FSPD---------GKLLaSGSADGTVRLWDL 233
WD40 COG2319
WD40 repeat [General function prediction only];
46-115 2.61e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.98  E-value: 2.61e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254574430  46 LVSADENGWVVWWDLGTKRPLGTWRAHESTIVTVQqmgihWDADvpqlhrntfGKLL-THGRDNCVRIWDL 115
Cdd:COG2319  135 LASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVA-----FSPD---------GKLLaSGSDDGTVRLWDL 191
WD40 COG2319
WD40 repeat [General function prediction only];
46-115 5.21e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.21  E-value: 5.21e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254574430  46 LVSADENGWVVWWDLGTKRPLGTWRAHESTIVTVQqmgihWDADvpqlhrntfGKLL-THGRDNCVRIWDL 115
Cdd:COG2319  303 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA-----FSPD---------GKTLaSGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
46-115 1.31e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.66  E-value: 1.31e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254574430  46 LVSADENGWVVWWDLGTKRPLGTWRAHESTIVTVqqmgiHWDADvpqlhrntfGKLL-THGRDNCVRIWDL 115
Cdd:COG2319  345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV-----AFSPD---------GRTLaSGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
46-114 1.49e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.40  E-value: 1.49e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254574430  46 LVSADENGWVVWWDLGTKRPLGTWRAHESTIVTVQqmgihWDADVPQlhrntfgkLLTHGRDNCVRIWD 114
Cdd:cd00200  234 LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLA-----WSPDGKR--------LASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
46-115 2.93e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.89  E-value: 2.93e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254574430  46 LVSADENGWVVWWDLGTKRPLGTWRAHESTIVTVqqmgiHWDADvpqlhrntfGKLLTHG-RDNCVRIWDL 115
Cdd:COG2319  219 LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV-----AFSPD---------GRLLASGsADGTVRLWDL 275
WD40 COG2319
WD40 repeat [General function prediction only];
46-115 7.66e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 38.35  E-value: 7.66e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254574430  46 LVSADENGWVVWWDLGTKRPLGTWRAHESTIVTVQqmgihWDADvpqlhrntfGKLL-THGRDNCVRIWDL 115
Cdd:COG2319  261 LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA-----FSPD---------GKLLaSGSDDGTVRLWDL 317
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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