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Conserved domains on  [gi|255568792|ref|XP_002525367|]
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uncharacterized protein LOC8282592 [Ricinus communis]

Protein Classification

DUF220 domain-containing protein( domain architecture ID 10327675)

DUF220 domain-containing protein shows some structural similarity to members of the START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) or Bet v1-like superfamily and may be involved in lipid binding

PubMed:  18922149

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF220 pfam02713
Domain of unknown function DUF220; This is family consists of a region in several Arabidopsis ...
 165-236 5.15e-44

Domain of unknown function DUF220; This is family consists of a region in several Arabidopsis thaliana hypothetical proteins none of which have any known function. The aligned region contains two cysteine residues. This domain shows structural similarity to members of the Bet v1-like superfamily and may be involved in lipid binding.


:

Pssm-ID: 460660  Cd Length: 73  Bit Score: 145.46  E-value: 5.15e-44
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 255568792  165 SGTISVHVLVDQNRKDLTMKFKQVKTGFMKQFEGCWRVEPVFIDQD-ICYPFKPKTWADYCWCTGGKGRIGSK 236
Cdd:pfam02713   1 SGTIPIHLIVDENRKDLTAKYKKEKMMFMKVFEGSWKVEPLYVDSErLCKPRKPKSREEYKKCSGGKGRIGSK 73
PasT super family cl43728
Ribosome association toxin PasT (RatA) of the RatAB toxin-antitoxin module [Translation, ...
 110-205 7.48e-05

Ribosome association toxin PasT (RatA) of the RatAB toxin-antitoxin module [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG2867:

Pssm-ID: 442114  Cd Length: 137  Bit Score: 42.16  E-value: 7.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255568792 110 VGLPPDAVYNIVTDPDNRRVFknIKEVISREVLLDEGHRQVVELEqaaiWKFLWWSGTISVHVLVDQNRKdltMKFKQVK 189
Cdd:COG2867   10 VPYSAEQMFDLVADVERYPEF--LPWCKAARVLERDGDEVVAELT----VSFKGLRESFTTRNTLDPPER---IDFELVD 80

                         90
                 ....*....|....*.
gi 255568792 190 TGFmKQFEGCWRVEPV 205
Cdd:COG2867   81 GPF-KHLEGRWRFEPL 95
 
Name Accession Description Interval E-value
DUF220 pfam02713
Domain of unknown function DUF220; This is family consists of a region in several Arabidopsis ...
 165-236 5.15e-44

Domain of unknown function DUF220; This is family consists of a region in several Arabidopsis thaliana hypothetical proteins none of which have any known function. The aligned region contains two cysteine residues. This domain shows structural similarity to members of the Bet v1-like superfamily and may be involved in lipid binding.


Pssm-ID: 460660  Cd Length: 73  Bit Score: 145.46  E-value: 5.15e-44
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 255568792  165 SGTISVHVLVDQNRKDLTMKFKQVKTGFMKQFEGCWRVEPVFIDQD-ICYPFKPKTWADYCWCTGGKGRIGSK 236
Cdd:pfam02713   1 SGTIPIHLIVDENRKDLTAKYKKEKMMFMKVFEGSWKVEPLYVDSErLCKPRKPKSREEYKKCSGGKGRIGSK 73
PasT COG2867
Ribosome association toxin PasT (RatA) of the RatAB toxin-antitoxin module [Translation, ...
 110-205 7.48e-05

Ribosome association toxin PasT (RatA) of the RatAB toxin-antitoxin module [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442114  Cd Length: 137  Bit Score: 42.16  E-value: 7.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255568792 110 VGLPPDAVYNIVTDPDNRRVFknIKEVISREVLLDEGHRQVVELEqaaiWKFLWWSGTISVHVLVDQNRKdltMKFKQVK 189
Cdd:COG2867   10 VPYSAEQMFDLVADVERYPEF--LPWCKAARVLERDGDEVVAELT----VSFKGLRESFTTRNTLDPPER---IDFELVD 80

                         90
                 ....*....|....*.
gi 255568792 190 TGFmKQFEGCWRVEPV 205
Cdd:COG2867   81 GPF-KHLEGRWRFEPL 95
SRPBCC_11 cd08866
Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Uncharacterized ...
 113-205 1.04e-04

Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.


Pssm-ID: 176875  Cd Length: 144  Bit Score: 41.83  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255568792 113 PPDAVYNIVTDPDNRRVFknIKEVISREVLLDEGHRQVVELE---QAAIWKFlwwsgTISVHVLVDQNRKDL-TMKFKQV 188
Cdd:cd08866   10 PPETVWAVLTDYDNLAEF--IPNLAESRLLERNGNRVVLEQTgkqGILFFKF-----EARVVLELREREEFPrELDFEMV 82

                         90
                 ....*....|....*..
gi 255568792 189 KTGFmKQFEGCWRVEPV 205
Cdd:cd08866   83 EGDF-KRFEGSWRLEPL 98
 
Name Accession Description Interval E-value
DUF220 pfam02713
Domain of unknown function DUF220; This is family consists of a region in several Arabidopsis ...
 165-236 5.15e-44

Domain of unknown function DUF220; This is family consists of a region in several Arabidopsis thaliana hypothetical proteins none of which have any known function. The aligned region contains two cysteine residues. This domain shows structural similarity to members of the Bet v1-like superfamily and may be involved in lipid binding.


Pssm-ID: 460660  Cd Length: 73  Bit Score: 145.46  E-value: 5.15e-44
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 255568792  165 SGTISVHVLVDQNRKDLTMKFKQVKTGFMKQFEGCWRVEPVFIDQD-ICYPFKPKTWADYCWCTGGKGRIGSK 236
Cdd:pfam02713   1 SGTIPIHLIVDENRKDLTAKYKKEKMMFMKVFEGSWKVEPLYVDSErLCKPRKPKSREEYKKCSGGKGRIGSK 73
PasT COG2867
Ribosome association toxin PasT (RatA) of the RatAB toxin-antitoxin module [Translation, ...
 110-205 7.48e-05

Ribosome association toxin PasT (RatA) of the RatAB toxin-antitoxin module [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442114  Cd Length: 137  Bit Score: 42.16  E-value: 7.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255568792 110 VGLPPDAVYNIVTDPDNRRVFknIKEVISREVLLDEGHRQVVELEqaaiWKFLWWSGTISVHVLVDQNRKdltMKFKQVK 189
Cdd:COG2867   10 VPYSAEQMFDLVADVERYPEF--LPWCKAARVLERDGDEVVAELT----VSFKGLRESFTTRNTLDPPER---IDFELVD 80

                         90
                 ....*....|....*.
gi 255568792 190 TGFmKQFEGCWRVEPV 205
Cdd:COG2867   81 GPF-KHLEGRWRFEPL 95
SRPBCC_11 cd08866
Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Uncharacterized ...
 113-205 1.04e-04

Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Uncharacterized group of the SRPBCC (START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC) domain superfamily. SRPBCC domains have a deep hydrophobic ligand-binding pocket and they bind diverse ligands. SRPBCC domains include the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domains of mammalian STARD1-STARD15, the C-terminal catalytic domains of the alpha oxygenase subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases (RHOs_alpha_C), Class I and II phosphatidylinositol transfer proteins (PITPs), Bet v 1 (the major pollen allergen of white birch, Betula verrucosa), CoxG, CalC, and related proteins. Other members of the superfamily include PYR/PYL/RCAR plant proteins, the aromatase/cyclase (ARO/CYC) domains of proteins such as Streptomyces glaucescens tetracenomycin, and the SRPBCC domains of Streptococcus mutans Smu.440 and related proteins.


Pssm-ID: 176875  Cd Length: 144  Bit Score: 41.83  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255568792 113 PPDAVYNIVTDPDNRRVFknIKEVISREVLLDEGHRQVVELE---QAAIWKFlwwsgTISVHVLVDQNRKDL-TMKFKQV 188
Cdd:cd08866   10 PPETVWAVLTDYDNLAEF--IPNLAESRLLERNGNRVVLEQTgkqGILFFKF-----EARVVLELREREEFPrELDFEMV 82

                         90
                 ....*....|....*..
gi 255568792 189 KTGFmKQFEGCWRVEPV 205
Cdd:cd08866   83 EGDF-KRFEGSWRLEPL 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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