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Conserved domains on  [gi|268565109|ref|XP_002647274|]
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Protein CBG06314 [Caenorhabditis briggsae]

Protein Classification

serpentine receptor( domain architecture ID 366230)

serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Srd super family cl22924
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 1-309 6.78e-113

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


The actual alignment was detected with superfamily member pfam10319:

Pssm-ID: 419896  Cd Length: 310  Bit Score: 329.97  E-value: 6.78e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565109    1 MFINWAHFIIPKMSLILTLIANPVFIYLIHTEKSFQFGSYKYLLLFFAIFNLIAAVFDTLVPCYVHIYRYSAVYFILDGP 80
Cdd:pfam10319   1 MYINWAHYYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565109   81 FFEKSRIGEFLVAGRCALIGGTYGVLNSHFVYRFLSLNNHHFVNQYFLPYGLILSMLWVLFHFLSWAVITDLLMLPDLES 160
Cdd:pfam10319  81 FFEYSELGQHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565109  161 RNYVRESFEKIYG--SMeNLSIKIAIYSEVSTEKMVDSWFGTSWVTLLNSYSVILYFVLGYKIMTSLSCGLDYMSPRTLL 238
Cdd:pfam10319 161 RDYIREDFRETYGvdSM-DINMLGALYWEASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKR 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 268565109  239 MQRRLFYALAIQTVIPIFVSFLPTVFVSYGAALGISVYSWISWGSAIAVTFFPFLDPLAITMCLPALRHRI 309
Cdd:pfam10319 240 LQKQLLKALIVQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
 
Name Accession Description Interval E-value
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 1-309 6.78e-113

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 329.97  E-value: 6.78e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565109    1 MFINWAHFIIPKMSLILTLIANPVFIYLIHTEKSFQFGSYKYLLLFFAIFNLIAAVFDTLVPCYVHIYRYSAVYFILDGP 80
Cdd:pfam10319   1 MYINWAHYYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565109   81 FFEKSRIGEFLVAGRCALIGGTYGVLNSHFVYRFLSLNNHHFVNQYFLPYGLILSMLWVLFHFLSWAVITDLLMLPDLES 160
Cdd:pfam10319  81 FFEYSELGQHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565109  161 RNYVRESFEKIYG--SMeNLSIKIAIYSEVSTEKMVDSWFGTSWVTLLNSYSVILYFVLGYKIMTSLSCGLDYMSPRTLL 238
Cdd:pfam10319 161 RDYIREDFRETYGvdSM-DINMLGALYWEASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKR 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 268565109  239 MQRRLFYALAIQTVIPIFVSFLPTVFVSYGAALGISVYSWISWGSAIAVTFFPFLDPLAITMCLPALRHRI 309
Cdd:pfam10319 240 LQKQLLKALIVQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
 
Name Accession Description Interval E-value
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 1-309 6.78e-113

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 329.97  E-value: 6.78e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565109    1 MFINWAHFIIPKMSLILTLIANPVFIYLIHTEKSFQFGSYKYLLLFFAIFNLIAAVFDTLVPCYVHIYRYSAVYFILDGP 80
Cdd:pfam10319   1 MYINWAHYYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565109   81 FFEKSRIGEFLVAGRCALIGGTYGVLNSHFVYRFLSLNNHHFVNQYFLPYGLILSMLWVLFHFLSWAVITDLLMLPDLES 160
Cdd:pfam10319  81 FFEYSELGQHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565109  161 RNYVRESFEKIYG--SMeNLSIKIAIYSEVSTEKMVDSWFGTSWVTLLNSYSVILYFVLGYKIMTSLSCGLDYMSPRTLL 238
Cdd:pfam10319 161 RDYIREDFRETYGvdSM-DINMLGALYWEASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKR 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 268565109  239 MQRRLFYALAIQTVIPIFVSFLPTVFVSYGAALGISVYSWISWGSAIAVTFFPFLDPLAITMCLPALRHRI 309
Cdd:pfam10319 240 LQKQLLKALIVQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 8-310 3.82e-40

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 142.98  E-value: 3.82e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565109    8 FIIPKMSLILTLIANPVFIYLIHTEKSFQFGSYKYLLLFFAIFNLIAAVFDTLVPCYVHIYRYSAVYFILDGPFFEKSRI 87
Cdd:pfam10326   2 HIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565109   88 GEFLVAGRCALIGGTYGVLNSHFVYRFLSLNNHHFVnQYFLPYGLILSMLWVLFHFLSWAVITDLLMLPDLESRNYVRES 167
Cdd:pfam10326  82 GQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKL-KYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565109  168 FEKIYG-SMENLS-IKIAIYSEVSTEKMV---DSWFGTS--WVTLLNSYSVILYF-VLGYKIMTSLScglDYMSPRTLLM 239
Cdd:pfam10326 161 LLENYNlDIDEVAyVGPVYYPTDENGSKVirwRSLIGLLimTFIIGISFSIIIYCgIKMYFKMKKLK---SLGSEKTRKL 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 268565109  240 QRRLFYALAIQTVIPIFVSFLPTVFVSYGAALGISVySWISWGSAIAVTFFPFLDPLAITMCLPALRHRIF 310
Cdd:pfam10326 238 QKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEI-GFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 16-296 1.83e-04

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 42.54  E-value: 1.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565109   16 ILTLIANPVFIYLIHTEKSFQFGSYKYLLLFFAIFNLIAAVFDTLVpCYVHIYRYSAVYFILDGP--FFEKSRIGEFLVA 93
Cdd:pfam10317  10 ILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFT-QQRIIPNGVSMALISYGPckYFGPWFCYSGYSL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565109   94 GRCALIGGTYGVLNShFVYRFLSLNNHHFVNQYFLPYGLILSMLWVLFHFLSWAVITDLLmlpdlESRNYVRESFEKIYG 173
Cdd:pfam10317  89 LQHFLLHSGWSLLLT-FYYRYYILKHVDPKRKKLILLIIIHYIPSLSQLIVIFLSPTDFL-----PVEALTKELHPNYNL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268565109  174 SMENLSIKIAIYSEVSTekmvdswFGTSWVTLLNSYSVILYFVLGYKIMTSLSCGLDYMSPRTLLMQRRLFYALAIQTVI 253
Cdd:pfam10317 163 TDYTVTGFSDLQSFPAL-------INTLIMTIPVFPIPIIILILRRKILKLLNSNSVNMSPTTKAQHRQLIKGLTIQALL 235

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 268565109  254 PIFvSFLPTVFVSYGAALGISVYSWISWGSAIAVTFFPFLDPL 296
Cdd:pfam10317 236 PLF-SYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPL 277
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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