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Conserved domains on  [gi|366989333|ref|XP_003674434|]
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hypothetical protein NCAS_0A14980 [Naumovozyma castellii]

Protein Classification

mediator of RNA polymerase II transcription subunit 17( domain architecture ID 10562700)

mediator of RNA polymerase II transcription subunit 17 (MED17) is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Med17 pfam10156
Subunit 17 of Mediator complex; This Mediator complex subunit was formerly known as Srb4 in ...
 20-567 0e+00

Subunit 17 of Mediator complex; This Mediator complex subunit was formerly known as Srb4 in yeasts or Trap80 in Drosophila and human. The Med17 subunit is located within the head domain and is essential for cell viability to the extent that a mutant strain of cerevisiae lacking it shows all RNA polymerase II-dependent transcription ceasing at non-permissive temperatures.


:

Pssm-ID: 401965  Cd Length: 441  Bit Score: 544.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366989333   20 TQGQGINLALDPNLINLTLspslitpgaipnsvndtgsqpdqspsaigtpgqnihntgtsliknpHEIYGQLPLSQLIPL 99
Cdd:pfam10156   2 TKESGIPLSLDPNLINLPL----------------------------------------------YEVFGQMPLAQLIPR 35

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366989333  100 ILQERGPsfkFADLSEERLMEELSNNGLSNEDKHTSppselEKPIDDDLMEIDFEDKnniskdesapesnipesnaiyqs 179
Cdd:pfam10156  36 ILQERGP---FRDLTEESLREEIEAEKQSPEDEDKS-----EGEEEDDEMKIDVEDT----------------------- 84

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366989333  180 sepQLTQEQFLKVRKDIVDHINMAMNESSLSLEFVSLLLSSVRENNANSSMSAFLKKNASPGSLNSDKIPYTPLSKEETN 259
Cdd:pfam10156  85 ---MMTQEEFAKARKEMIEHINMALNESSLALDFISLLLSKVRESQAASSMSPFLKKTVPPGSLNSDKVPAPPKTKAEKL 161

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366989333  260 QLEVLNKGWKLKSLNDSRIMLKENYLKLSASLQREHIYWKKVsnhINNSDVIFKLRDKTTGQRSLGIKYGYEDSGSTYKl 339
Cdd:pfam10156 162 ELALLNKGWKLKSLNEARDLLKEAAARLEKEVEKEHKYWEEI---ISNSDVGWKIRDKPTGKRSLGVKYGYEDAGSTFK- 237

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366989333  340 DRGIAILRNNPLTDLLELVPFqnsdsdvaLRNYEKFIRVRIFTKiesEDDYILSGESLIDNEDGFEgilgsdhsqndpkf 419
Cdd:pfam10156 238 DRGLAPLRRNPEGSILLLVPI--------LGSKEKFLRVRIFTK---EDDYILSGESSLPTLLKSD-------------- 292

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366989333  420 FEDIRFQIKILKKFILEKELMYQLKKESSRLISYGVTIENeNKVIIELPNEKFEIELLSLTDSSLIDHERDAPKVNDKRA 499
Cdd:pfam10156 293 DSDIRKQIEKARNTIFEEELMYELKKEARQLISYGVSFEN-NKIVIELPNEKIEIELVSLDDSSPVNHEQDAPKPNDKRA 371

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366989333  500 NLMHVTLRMLLVVIFKKNLKNKLMSPK--VKKNLNIDKDILLIRPILGRMRHSNYKMLLKKLLENHVLNI 567
Cdd:pfam10156 372 NLILITLRLLLVVIFRKNLRRRLPPPKtaAKRSRSPPKDILLLRPILGKLRHQNYKSLLRKILKTLVLTL 441
 
Name Accession Description Interval E-value
Med17 pfam10156
Subunit 17 of Mediator complex; This Mediator complex subunit was formerly known as Srb4 in ...
 20-567 0e+00

Subunit 17 of Mediator complex; This Mediator complex subunit was formerly known as Srb4 in yeasts or Trap80 in Drosophila and human. The Med17 subunit is located within the head domain and is essential for cell viability to the extent that a mutant strain of cerevisiae lacking it shows all RNA polymerase II-dependent transcription ceasing at non-permissive temperatures.


Pssm-ID: 401965  Cd Length: 441  Bit Score: 544.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366989333   20 TQGQGINLALDPNLINLTLspslitpgaipnsvndtgsqpdqspsaigtpgqnihntgtsliknpHEIYGQLPLSQLIPL 99
Cdd:pfam10156   2 TKESGIPLSLDPNLINLPL----------------------------------------------YEVFGQMPLAQLIPR 35

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366989333  100 ILQERGPsfkFADLSEERLMEELSNNGLSNEDKHTSppselEKPIDDDLMEIDFEDKnniskdesapesnipesnaiyqs 179
Cdd:pfam10156  36 ILQERGP---FRDLTEESLREEIEAEKQSPEDEDKS-----EGEEEDDEMKIDVEDT----------------------- 84

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366989333  180 sepQLTQEQFLKVRKDIVDHINMAMNESSLSLEFVSLLLSSVRENNANSSMSAFLKKNASPGSLNSDKIPYTPLSKEETN 259
Cdd:pfam10156  85 ---MMTQEEFAKARKEMIEHINMALNESSLALDFISLLLSKVRESQAASSMSPFLKKTVPPGSLNSDKVPAPPKTKAEKL 161

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366989333  260 QLEVLNKGWKLKSLNDSRIMLKENYLKLSASLQREHIYWKKVsnhINNSDVIFKLRDKTTGQRSLGIKYGYEDSGSTYKl 339
Cdd:pfam10156 162 ELALLNKGWKLKSLNEARDLLKEAAARLEKEVEKEHKYWEEI---ISNSDVGWKIRDKPTGKRSLGVKYGYEDAGSTFK- 237

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366989333  340 DRGIAILRNNPLTDLLELVPFqnsdsdvaLRNYEKFIRVRIFTKiesEDDYILSGESLIDNEDGFEgilgsdhsqndpkf 419
Cdd:pfam10156 238 DRGLAPLRRNPEGSILLLVPI--------LGSKEKFLRVRIFTK---EDDYILSGESSLPTLLKSD-------------- 292

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366989333  420 FEDIRFQIKILKKFILEKELMYQLKKESSRLISYGVTIENeNKVIIELPNEKFEIELLSLTDSSLIDHERDAPKVNDKRA 499
Cdd:pfam10156 293 DSDIRKQIEKARNTIFEEELMYELKKEARQLISYGVSFEN-NKIVIELPNEKIEIELVSLDDSSPVNHEQDAPKPNDKRA 371

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366989333  500 NLMHVTLRMLLVVIFKKNLKNKLMSPK--VKKNLNIDKDILLIRPILGRMRHSNYKMLLKKLLENHVLNI 567
Cdd:pfam10156 372 NLILITLRLLLVVIFRKNLRRRLPPPKtaAKRSRSPPKDILLLRPILGKLRHQNYKSLLRKILKTLVLTL 441
 
Name Accession Description Interval E-value
Med17 pfam10156
Subunit 17 of Mediator complex; This Mediator complex subunit was formerly known as Srb4 in ...
 20-567 0e+00

Subunit 17 of Mediator complex; This Mediator complex subunit was formerly known as Srb4 in yeasts or Trap80 in Drosophila and human. The Med17 subunit is located within the head domain and is essential for cell viability to the extent that a mutant strain of cerevisiae lacking it shows all RNA polymerase II-dependent transcription ceasing at non-permissive temperatures.


Pssm-ID: 401965  Cd Length: 441  Bit Score: 544.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366989333   20 TQGQGINLALDPNLINLTLspslitpgaipnsvndtgsqpdqspsaigtpgqnihntgtsliknpHEIYGQLPLSQLIPL 99
Cdd:pfam10156   2 TKESGIPLSLDPNLINLPL----------------------------------------------YEVFGQMPLAQLIPR 35

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366989333  100 ILQERGPsfkFADLSEERLMEELSNNGLSNEDKHTSppselEKPIDDDLMEIDFEDKnniskdesapesnipesnaiyqs 179
Cdd:pfam10156  36 ILQERGP---FRDLTEESLREEIEAEKQSPEDEDKS-----EGEEEDDEMKIDVEDT----------------------- 84

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366989333  180 sepQLTQEQFLKVRKDIVDHINMAMNESSLSLEFVSLLLSSVRENNANSSMSAFLKKNASPGSLNSDKIPYTPLSKEETN 259
Cdd:pfam10156  85 ---MMTQEEFAKARKEMIEHINMALNESSLALDFISLLLSKVRESQAASSMSPFLKKTVPPGSLNSDKVPAPPKTKAEKL 161

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366989333  260 QLEVLNKGWKLKSLNDSRIMLKENYLKLSASLQREHIYWKKVsnhINNSDVIFKLRDKTTGQRSLGIKYGYEDSGSTYKl 339
Cdd:pfam10156 162 ELALLNKGWKLKSLNEARDLLKEAAARLEKEVEKEHKYWEEI---ISNSDVGWKIRDKPTGKRSLGVKYGYEDAGSTFK- 237

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366989333  340 DRGIAILRNNPLTDLLELVPFqnsdsdvaLRNYEKFIRVRIFTKiesEDDYILSGESLIDNEDGFEgilgsdhsqndpkf 419
Cdd:pfam10156 238 DRGLAPLRRNPEGSILLLVPI--------LGSKEKFLRVRIFTK---EDDYILSGESSLPTLLKSD-------------- 292

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366989333  420 FEDIRFQIKILKKFILEKELMYQLKKESSRLISYGVTIENeNKVIIELPNEKFEIELLSLTDSSLIDHERDAPKVNDKRA 499
Cdd:pfam10156 293 DSDIRKQIEKARNTIFEEELMYELKKEARQLISYGVSFEN-NKIVIELPNEKIEIELVSLDDSSPVNHEQDAPKPNDKRA 371

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 366989333  500 NLMHVTLRMLLVVIFKKNLKNKLMSPK--VKKNLNIDKDILLIRPILGRMRHSNYKMLLKKLLENHVLNI 567
Cdd:pfam10156 372 NLILITLRLLLVVIFRKNLRRRLPPPKtaAKRSRSPPKDILLLRPILGKLRHQNYKSLLRKILKTLVLTL 441
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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