DNA double-strand break repair Rad50 ATPase;

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410084749 495 TLNSQLEIYDEQEESLAQQRRQNERLLQIYgghttndedvdEELQLRIALLEsQDNQDSTATSTqniGTEDDDEEFRRIL 574
Cdd:PRK02224 217 ELDEEIERYEEQREQARETRDEADEVLEEH-----------EERREELETLE-AEIEDLRETIA---ETEREREELAEEV 281

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 410084749 575 EESQRQA-EIDQRRTPVSHE------------------DDDDEELRRALEQSRLEQQEPEQRATT 620
Cdd:PRK02224 282 RDLRERLeELEEERDDLLAEaglddadaeavearreelEDRDEELRDRLEECRVAAQAHNEEAES 346

F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called FBX11, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 410084749  26 LPAEILINIFSNLNEQDLNTLKTVSNHFNSLITDEELWKNL 66
Cdd:cd22091    4 LPDEVLLKIFSYLLEQDLCRAAQVCKRFNTLANDPELWKRL 44

DNA double-strand break repair Rad50 ATPase;

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410084749 495 TLNSQLEIYDEQEESLAQQRRQNERLLQIYgghttndedvdEELQLRIALLEsQDNQDSTATSTqniGTEDDDEEFRRIL 574
Cdd:PRK02224 217 ELDEEIERYEEQREQARETRDEADEVLEEH-----------EERREELETLE-AEIEDLRETIA---ETEREREELAEEV 281

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 410084749 575 EESQRQA-EIDQRRTPVSHE------------------DDDDEELRRALEQSRLEQQEPEQRATT 620
Cdd:PRK02224 282 RDLRERLeELEEERDDLLAEaglddadaeavearreelEDRDEELRDRLEECRVAAQAHNEEAES 346

F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called FBX11, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 410084749  26 LPAEILINIFSNLNEQDLNTLKTVSNHFNSLITDEELWKNL 66
Cdd:cd22091    4 LPDEVLLKIFSYLLEQDLCRAAQVCKRFNTLANDPELWKRL 44

F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 410084749  23 LELLPAEILINIFSNLNEQDLNTLKTVSNHFNSLITDEELWKNL 66
Cdd:cd22084    1 LDDLPSDPLLNILSFLDYRDLISCSQVCRRLNQLCSHDPLWKRL 44

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 410084749   23 LELLPAEILINIFSNLNEQDLNTLKTVSNHFNSLITDEELWKN 65
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43

F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also called F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, or p45SKP2-like protein, is the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 410084749  23 LELLPAEILINIFSNLNEQDLNTLKTVSNHFNSLITDEELW 63
Cdd:cd22118    1 ISSLPPEIMLKIFSYLNPQDLCRCAQVCTKWSQLARDGSLW 41

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 410084749  23 LELLPAEILINIFSNLNEQDLNTLKTVSNHFNSLITDEELWKNLL 67
Cdd:cd22147    2 LSALPVELSLKILSYLDAKSLCRAAQVSKKWRNLADDDELWKRMC 46

F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and similar proteins; DmSKP2 is a Drosophila F-box protein that regulates cell proliferation by targeting Dacapo (Dap) for ubiquitination and proteasome-mediated degradation. It plays a role in maintaining diploidy of mitotic cells during development. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 410084749  24 ELLPAEILINIFSNLNEQDLNTLKTVSNHFNSLITDEELWK 64
Cdd:cd22149    2 ERLSDEIILSIFKWLPKKTLARCARVCRRWKRLCFDESLWR 42

DNA double-strand break repair Rad50 ATPase;

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 410084749 495 TLNSQLEIYDEQEESLAQQRRQNERLLQIYgghttndedvdEELQLRIALLEsQDNQDSTATSTqniGTEDDDEEFRRIL 574
Cdd:PRK02224 217 ELDEEIERYEEQREQARETRDEADEVLEEH-----------EERREELETLE-AEIEDLRETIA---ETEREREELAEEV 281

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 410084749 575 EESQRQA-EIDQRRTPVSHE------------------DDDDEELRRALEQSRLEQQEPEQRATT 620
Cdd:PRK02224 282 RDLRERLeELEEERDDLLAEaglddadaeavearreelEDRDEELRDRLEECRVAAQAHNEEAES 346

F-box domain found in F-box only protein 8 (FBXO8) and similar proteins; FBXO8, also called FBX8, or F-box/SEC7 protein FBS, is a novel component of F-box proteins which contains an F-box domain and a putative Sec7 domain. FBX8 was originally identified as a Skp1-binding protein. It is involved in the ubiquitin-dependent proteolytic pathway. It acts as a metastasis suppressor that functions through mTOR signaling pathway. FBXO8 may promote the activation of ADP-ribosylation factor (ARF) through replacement of GDP with GTP. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 410084749  23 LELLPAEILINIFSNLNEQDLNTLKTVsnhFNSLITDEELWKNL 66
Cdd:cd22088    4 LEELPPELSLTVLSHLNATDLCLASCV---WQDLANDELLWQGL 44

F-box domain found in Saccharomyces cerevisiae cell division control protein 4 (ScCDC4) and similar proteins; ScCDC4 is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It is essential for initiation of DNA replication and separation of the spindle pole bodies to form the poles of the mitotic spindle. It also plays a role in bud development, fusion of zygotic nuclei after conjugation and various aspects of sporulation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 410084749  26 LPAEILINIFSNLNEQDLNTLKTVSNHFNSLITDEELWKNLLIS 69
Cdd:cd22141    4 LPFEISLKIFNYLQFEDLLNSLGVSKKWNKIIRNTALWKKLLIS 47

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 31 (AtSKIP31) and similar proteins; AtSKIP31, also called F-box protein SKIP31, is a component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 410084749  26 LPAEILINIFSNLNEQDLNTLKTVSNHFNSLITDEELWKNL 66
Cdd:cd22166    4 LPPELFRHILKFLSPEDLTSCATVCRFLRGAASDESLWRRL 44

F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) and similar proteins; DdgacFF, also called GTPase activating factor for raC protein FF, is a Rho GTPase-activating protein involved in the signal transduction pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 410084749  23 LELLPAEILINIFSNLNEQDLNTLKTVSNHFNSLITDEELWK 64
Cdd:cd22148    2 ISLLPEHLALKILSYLSPKELLIASQVSKTWRRLASSNELWK 43

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 410084749  561 IGTeDDDEEFRRILEESQRQAEI-----DQRRTPVSHEDD-DDEELRRALEQSRLEQQEPEQRA 618
Cdd:pfam05672   4 AGT-TDAEEAARILAEKRRQAREqrereEQERLEKEEEERlRKEELRRRAEEERARREEEARRL 66

F-box domain found in F-box only protein 46 (FBXO46) and similar proteins; FBXO46, also called FBX46, or F-box only protein 34-like, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|...
gi 410084749  25 LLPAEILINIFSNLNEQDLNTLKTVSNHFNSLI 57
Cdd:cd22177    3 LLPDHILVNIFSYLPTRSLAALKCSCHHFKDII 35

F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called FBX15, has a novel dual molecular function by controlling transcriptional repression and being part of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligases, which is essential for stress response, gliotoxin production and virulence in the opportunistic human pathogen Aspergillus fumigatus. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 410084749  23 LELLPAEILINIFSNLNEQDLNTLKTVSNHFNSLITDEELWKNL 66
Cdd:cd22093    1 IERLPSEILLKILSYLDASSLLCISCVNKLFYQLANDNALWRKL 44