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Conserved domains on  [gi|1567504017|ref|XP_004012508|]
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protein unc-45 homolog B [Ovis aries]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UNC45-central pfam11701
Myosin-binding striated muscle assembly central; The UNC-45 or small muscle protein 1 of C. ...
 344-489 1.77e-34

Myosin-binding striated muscle assembly central; The UNC-45 or small muscle protein 1 of C.elegans is expressed in two forms from different genomic positions in mammals, as a general tissue protein UNC-45a and a specific form Unc-45b expressed only in striated and skeletal muscle. All members carry up to three amino-terminal tetratricopeptide repeat (TPR) domains towards their N-terminal, a UCS domain at the C-terminal that contains a number of Arm repeats pfam00514 and this central region of approximately 400 residues. Both the general form and the muscle form of UNC-45 function in myotube formation through cell fusion. Myofibril formation requires both GC and SM UNC-45, consistent with the fact that the cytoskeleton is necessary for the development and maintenance of organized myofibrils. The S. pombe Rng3p, is crucial for cell shape, normal actin cytoskeleton, and contractile ring assembly, and is essential for assembly of the myosin II-containing progenitors of the contractile ring. Widespread defects in the cytoskeleton are found in null mutants of all three fungal proteins. Mammalian Unc45 is found to act as a specific chaperone during the folding of myosin and the assembly of striated muscle by forming a stable complex with the general chaperone Hsp90. The exact function of this central region is not known.


:

Pssm-ID: 432011  Cd Length: 151  Bit Score: 128.81  E-value: 1.77e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017 344 CLPLTDNTRMLASILINKLyddlrCDPERDHFRKICEEYITGTFDPQDMDKNVIAIQTVSGILQGPFDLGNQLLGLKGVM 423
Cdd:pfam11701  11 DLRLPESVRSLALLILSKL-----LEAAKEEFEEKFSEFITSLLADGTNDDLIIAFSALAALFPVPPDVASALFLSEGFL 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1567504017 424 EMMVALCGS-ERETDQLVAVEALIHASTKLSRATFIITNGVSLLKEIYKTTKNEkIKIRALVGLCKL 489
Cdd:pfam11701  86 ESLLPLVESkKSRKVELAALELLSAACIDKACREAISKNYVDWLEELLKSSDDE-IKALAAVVLAKL 151
3a0801s09 super family cl36792
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 3-134 7.19e-12

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


The actual alignment was detected with superfamily member TIGR00990:

Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 69.24  E-value: 7.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017   3 EAEAMQLKEEGNQHFQLQDYKAATKSYSQALKLTKDkallATLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYR 82
Cdd:TIGR00990 124 KKYAAKLKEKGNKAYRNKDFNKAIKLYSKAIECKPD----PVYYSNRAACHNALGDWEKVVEDTTAALELDPDYSKALNR 199

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1567504017  83 RCQALEHLGKLDQAFKDVQRCATLEPQN--QSFQETLRRLNTSIQEKLRVQFST 134
Cdd:TIGR00990 200 RANAYDGLGKYADALLDLTASCIIDGFRneQSAQAVERLLKKFAESKAKEILET 253
INSC_LBD super family cl41917
LGN-binding domain (LBD) of protein Inscuteable (INSC) and similar proteins; Inscuteable (INSC) ...
 87-288 6.47e-03

LGN-binding domain (LBD) of protein Inscuteable (INSC) and similar proteins; Inscuteable (INSC) functions as an adapter protein linking the Par polarity complex (composed of Par3, Par6 and protein kinase C iota) to the Gpsm1/Gpsm2 complex, and is involved in cell polarity and spindle orientation during mitosis. Par3 interacts with INSC which binds directly to Pins (partner of Insc, homolog of vertebrate LGN/Gpsm2 and AGS3/Gpsm1). Pins then associates with the heterotrimeric G proteins and NuMA, which interacts directly with the cell spindle to control the orientation of the spindle and the division plane of mitotic cells. INSC may regulate cell proliferation and differentiation in the developing nervous system, may play a role in the asymmetric division of fibroblasts, and may also participate in the process of stratification of the squamous epithelium. This model corresponds to the Leu-Gly-Asn Repeat-Enriched Protein (LGN)-binding domain (LBD) of INSC. It interacts with the tetratricopeptide repeat (TPR) motifs of LGN, also called G-protein-signaling modulator 2 (Gpsm2).


The actual alignment was detected with superfamily member cd21966:

Pssm-ID: 477865 [Multi-domain]  Cd Length: 300  Bit Score: 39.55  E-value: 6.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017  87 LEHLGKLDQAFKdvqRCATLEPQNQSFQETLRRLNTSIQEKLRVQFSTDsrVQTMFEILLDRNSEADkLEKAANNLIVLS 166
Cdd:cd21966   114 LEICEELRTAAE---RSLGSKPNLEELLKLLTTLGQSFSKLVDLLLLKE--LQILVDSLEEPTSELS-LRAALSALTSLG 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017 167 REEAGAERIF-QNNGM-ALLMQLLDTKRPELMLAAVRTLSGMCsshraratailhavridriCSLMAVESEEMSLAVcnl 244
Cdd:cd21966   188 LEGPHLCRLIaKEGGVrALLIVCRDCKSSSVRALALRALATVC-------------------CVPEAIRQFEKAGGI--- 245

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1567504017 245 lQAIIDALSDEDKQEHRGKEEALVL--------DSKKDLKQITNHLLDMLVS 288
Cdd:cd21966   246 -EILSDILTDESRSEPERSEAAGVLaqitspwiDDNHHLSGLIEHMEDLVKA 296
 
Name Accession Description Interval E-value
UNC45-central pfam11701
Myosin-binding striated muscle assembly central; The UNC-45 or small muscle protein 1 of C. ...
 344-489 1.77e-34

Myosin-binding striated muscle assembly central; The UNC-45 or small muscle protein 1 of C.elegans is expressed in two forms from different genomic positions in mammals, as a general tissue protein UNC-45a and a specific form Unc-45b expressed only in striated and skeletal muscle. All members carry up to three amino-terminal tetratricopeptide repeat (TPR) domains towards their N-terminal, a UCS domain at the C-terminal that contains a number of Arm repeats pfam00514 and this central region of approximately 400 residues. Both the general form and the muscle form of UNC-45 function in myotube formation through cell fusion. Myofibril formation requires both GC and SM UNC-45, consistent with the fact that the cytoskeleton is necessary for the development and maintenance of organized myofibrils. The S. pombe Rng3p, is crucial for cell shape, normal actin cytoskeleton, and contractile ring assembly, and is essential for assembly of the myosin II-containing progenitors of the contractile ring. Widespread defects in the cytoskeleton are found in null mutants of all three fungal proteins. Mammalian Unc45 is found to act as a specific chaperone during the folding of myosin and the assembly of striated muscle by forming a stable complex with the general chaperone Hsp90. The exact function of this central region is not known.


Pssm-ID: 432011  Cd Length: 151  Bit Score: 128.81  E-value: 1.77e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017 344 CLPLTDNTRMLASILINKLyddlrCDPERDHFRKICEEYITGTFDPQDMDKNVIAIQTVSGILQGPFDLGNQLLGLKGVM 423
Cdd:pfam11701  11 DLRLPESVRSLALLILSKL-----LEAAKEEFEEKFSEFITSLLADGTNDDLIIAFSALAALFPVPPDVASALFLSEGFL 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1567504017 424 EMMVALCGS-ERETDQLVAVEALIHASTKLSRATFIITNGVSLLKEIYKTTKNEkIKIRALVGLCKL 489
Cdd:pfam11701  86 ESLLPLVESkKSRKVELAALELLSAACIDKACREAISKNYVDWLEELLKSSDDE-IKALAAVVLAKL 151
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 3-134 7.19e-12

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 69.24  E-value: 7.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017   3 EAEAMQLKEEGNQHFQLQDYKAATKSYSQALKLTKDkallATLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYR 82
Cdd:TIGR00990 124 KKYAAKLKEKGNKAYRNKDFNKAIKLYSKAIECKPD----PVYYSNRAACHNALGDWEKVVEDTTAALELDPDYSKALNR 199

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1567504017  83 RCQALEHLGKLDQAFKDVQRCATLEPQN--QSFQETLRRLNTSIQEKLRVQFST 134
Cdd:TIGR00990 200 RANAYDGLGKYADALLDLTASCIIDGFRneQSAQAVERLLKKFAESKAKEILET 253
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
5-110 5.05e-11

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 63.40  E-value: 5.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017   5 EAMQLKEEGNQHFQLQDYKAATKSYSQALKLTKDkalLATLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRC 84
Cdd:COG4785    72 LAQLYYERGVAYDSLGDYDLAIADFDQALELDPD---LAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRG 148

                          90       100
                  ....*....|....*....|....*.
gi 1567504017  85 QALEHLGKLDQAFKDVQRCATLEPQN 110
Cdd:COG4785   149 IALYYLGRYELAIADLEKALELDPND 174
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 6-126 8.82e-08

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 55.18  E-value: 8.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017   6 AMQLKEEGNQHFQLQDYKAATKSYSQALKLTKDKAllaTLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQ 85
Cdd:PLN03088    2 AKDLEDKAKEAFVDDDFALAVDLYTQAIDLDPNNA---ELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGT 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1567504017  86 ALEHLGKLDQAFKDVQRCATLEPQNQSFQETLRRLNTSIQE 126
Cdd:PLN03088   79 ACMKLEEYQTAKAALEKGASLAPGDSRFTKLIKECDEKIAE 119
INSC_LBD cd21966
LGN-binding domain (LBD) of protein Inscuteable (INSC) and similar proteins; Inscuteable (INSC) ...
 87-288 6.47e-03

LGN-binding domain (LBD) of protein Inscuteable (INSC) and similar proteins; Inscuteable (INSC) functions as an adapter protein linking the Par polarity complex (composed of Par3, Par6 and protein kinase C iota) to the Gpsm1/Gpsm2 complex, and is involved in cell polarity and spindle orientation during mitosis. Par3 interacts with INSC which binds directly to Pins (partner of Insc, homolog of vertebrate LGN/Gpsm2 and AGS3/Gpsm1). Pins then associates with the heterotrimeric G proteins and NuMA, which interacts directly with the cell spindle to control the orientation of the spindle and the division plane of mitotic cells. INSC may regulate cell proliferation and differentiation in the developing nervous system, may play a role in the asymmetric division of fibroblasts, and may also participate in the process of stratification of the squamous epithelium. This model corresponds to the Leu-Gly-Asn Repeat-Enriched Protein (LGN)-binding domain (LBD) of INSC. It interacts with the tetratricopeptide repeat (TPR) motifs of LGN, also called G-protein-signaling modulator 2 (Gpsm2).


Pssm-ID: 439320 [Multi-domain]  Cd Length: 300  Bit Score: 39.55  E-value: 6.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017  87 LEHLGKLDQAFKdvqRCATLEPQNQSFQETLRRLNTSIQEKLRVQFSTDsrVQTMFEILLDRNSEADkLEKAANNLIVLS 166
Cdd:cd21966   114 LEICEELRTAAE---RSLGSKPNLEELLKLLTTLGQSFSKLVDLLLLKE--LQILVDSLEEPTSELS-LRAALSALTSLG 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017 167 REEAGAERIF-QNNGM-ALLMQLLDTKRPELMLAAVRTLSGMCsshraratailhavridriCSLMAVESEEMSLAVcnl 244
Cdd:cd21966   188 LEGPHLCRLIaKEGGVrALLIVCRDCKSSSVRALALRALATVC-------------------CVPEAIRQFEKAGGI--- 245

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1567504017 245 lQAIIDALSDEDKQEHRGKEEALVL--------DSKKDLKQITNHLLDMLVS 288
Cdd:cd21966   246 -EILSDILTDESRSEPERSEAAGVLaqitspwiDDNHHLSGLIEHMEDLVKA 296
 
Name Accession Description Interval E-value
UNC45-central pfam11701
Myosin-binding striated muscle assembly central; The UNC-45 or small muscle protein 1 of C. ...
 344-489 1.77e-34

Myosin-binding striated muscle assembly central; The UNC-45 or small muscle protein 1 of C.elegans is expressed in two forms from different genomic positions in mammals, as a general tissue protein UNC-45a and a specific form Unc-45b expressed only in striated and skeletal muscle. All members carry up to three amino-terminal tetratricopeptide repeat (TPR) domains towards their N-terminal, a UCS domain at the C-terminal that contains a number of Arm repeats pfam00514 and this central region of approximately 400 residues. Both the general form and the muscle form of UNC-45 function in myotube formation through cell fusion. Myofibril formation requires both GC and SM UNC-45, consistent with the fact that the cytoskeleton is necessary for the development and maintenance of organized myofibrils. The S. pombe Rng3p, is crucial for cell shape, normal actin cytoskeleton, and contractile ring assembly, and is essential for assembly of the myosin II-containing progenitors of the contractile ring. Widespread defects in the cytoskeleton are found in null mutants of all three fungal proteins. Mammalian Unc45 is found to act as a specific chaperone during the folding of myosin and the assembly of striated muscle by forming a stable complex with the general chaperone Hsp90. The exact function of this central region is not known.


Pssm-ID: 432011  Cd Length: 151  Bit Score: 128.81  E-value: 1.77e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017 344 CLPLTDNTRMLASILINKLyddlrCDPERDHFRKICEEYITGTFDPQDMDKNVIAIQTVSGILQGPFDLGNQLLGLKGVM 423
Cdd:pfam11701  11 DLRLPESVRSLALLILSKL-----LEAAKEEFEEKFSEFITSLLADGTNDDLIIAFSALAALFPVPPDVASALFLSEGFL 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1567504017 424 EMMVALCGS-ERETDQLVAVEALIHASTKLSRATFIITNGVSLLKEIYKTTKNEkIKIRALVGLCKL 489
Cdd:pfam11701  86 ESLLPLVESkKSRKVELAALELLSAACIDKACREAISKNYVDWLEELLKSSDDE-IKALAAVVLAKL 151
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 3-134 7.19e-12

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 69.24  E-value: 7.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017   3 EAEAMQLKEEGNQHFQLQDYKAATKSYSQALKLTKDkallATLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYR 82
Cdd:TIGR00990 124 KKYAAKLKEKGNKAYRNKDFNKAIKLYSKAIECKPD----PVYYSNRAACHNALGDWEKVVEDTTAALELDPDYSKALNR 199

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1567504017  83 RCQALEHLGKLDQAFKDVQRCATLEPQN--QSFQETLRRLNTSIQEKLRVQFST 134
Cdd:TIGR00990 200 RANAYDGLGKYADALLDLTASCIIDGFRneQSAQAVERLLKKFAESKAKEILET 253
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
5-110 5.05e-11

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 63.40  E-value: 5.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017   5 EAMQLKEEGNQHFQLQDYKAATKSYSQALKLTKDkalLATLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRC 84
Cdd:COG4785    72 LAQLYYERGVAYDSLGDYDLAIADFDQALELDPD---LAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRG 148

                          90       100
                  ....*....|....*....|....*.
gi 1567504017  85 QALEHLGKLDQAFKDVQRCATLEPQN 110
Cdd:COG4785   149 IALYYLGRYELAIADLEKALELDPND 174
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
13-110 3.08e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 58.48  E-value: 3.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017  13 GNQHFQLQDYKAATKSYSQALKLTKDkalLATLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQALEHLGK 92
Cdd:COG0457    15 GLAYRRLGRYEEAIEDYEKALELDPD---DAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGR 91

                          90
                  ....*....|....*...
gi 1567504017  93 LDQAFKDVQRCATLEPQN 110
Cdd:COG0457    92 YEEALEDYDKALELDPDD 109
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
13-120 7.49e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 57.32  E-value: 7.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017  13 GNQHFQLQDYKAATKSYSQALKLTKDkalLATLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQALEHLGK 92
Cdd:COG0457    49 GLAYLRLGRYEEALADYEQALELDPD---DAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGR 125

                          90       100
                  ....*....|....*....|....*...
gi 1567504017  93 LDQAFKDVQRCATLEPQNQSFQETLRRL 120
Cdd:COG0457   126 YDEAIEAYERALELDPDDADALYNLGIA 153
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 2-110 1.08e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 58.85  E-value: 1.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017   2 AEAEAMQLKEEGNQHFQLQDYKAATKSYSQALKLTKDkalLATLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALY 81
Cdd:COG3914    74 LLLLAALLELAALLLQALGRYEEALALYRRALALNPD---NAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYL 150

                          90       100
                  ....*....|....*....|....*....
gi 1567504017  82 RRCQALEHLGKLDQAFKDVQRCATLEPQN 110
Cdd:COG3914   151 NLGEALRRLGRLEEAIAALRRALELDPDN 179
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 13-110 4.59e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 56.93  E-value: 4.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017  13 GNQHFQLQDYKAATKSYSQALKLTKDkalLATLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQALEHLGK 92
Cdd:COG3914   119 GNLLLALGRLEEALAALRRALALNPD---FAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGR 195

                          90
                  ....*....|....*...
gi 1567504017  93 LDQAFKDVQRCATLEPQN 110
Cdd:COG3914   196 LEEAIAAYRRALELDPDN 213
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 6-126 8.82e-08

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 55.18  E-value: 8.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017   6 AMQLKEEGNQHFQLQDYKAATKSYSQALKLTKDKAllaTLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQ 85
Cdd:PLN03088    2 AKDLEDKAKEAFVDDDFALAVDLYTQAIDLDPNNA---ELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGT 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1567504017  86 ALEHLGKLDQAFKDVQRCATLEPQNQSFQETLRRLNTSIQE 126
Cdd:PLN03088   79 ACMKLEEYQTAKAALEKGASLAPGDSRFTKLIKECDEKIAE 119
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 13-121 8.98e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 51.93  E-value: 8.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017  13 GNQHFQLQDYKAATKSYSQALKLTKDKAllaTLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQALEHLGK 92
Cdd:COG4235    24 GRAYLRLGRYDEALAAYEKALRLDPDNA---DALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGD 100

                          90       100
                  ....*....|....*....|....*....
gi 1567504017  93 LDQAFKDVQRCATLEPQNQSFQETLRRLN 121
Cdd:COG4235   101 YAEAIAAWQKLLALLPADAPARLLEASIA 129
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 3-120 2.05e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 50.96  E-value: 2.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017   3 EAEAMQLKEEGNQHFQLQDYKAATKSYSQALKLTKDKAllaTLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYR 82
Cdd:COG4783     1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNP---EAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLN 77

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1567504017  83 RCQALEHLGKLDQAFKDVQRCATLEPQNQSFQETLRRL 120
Cdd:COG4783    78 LGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARA 115
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
13-177 4.72e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.93  E-value: 4.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017  13 GNQHFQLQDYKAATKSYSQALKLTKDkalLATLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQALEHLGK 92
Cdd:COG0457    83 GLALQALGRYEEALEDYDKALELDPD---DAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGR 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017  93 LDQAFKDVQRCATLEPQNQSFQETLRRLNTSIQEKLRVQFSTDSRVQTMFEILLDRNSEADKLEKAANNLIVLSREEAGA 172
Cdd:COG0457   160 YEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALA 239


                  ....*
gi 1567504017 173 ERIFQ 177
Cdd:COG0457   240 LYQYR 244
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
16-108 1.66e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 47.09  E-value: 1.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017  16 HFQLQDYKAATKSYSQALKLTKDkalLATLYRNRAACGLKTESYVQAAsDASRAIDINSSDIKALYRRCQALEHLGKLDQ 95
Cdd:COG3063     2 YLKLGDLEEAEEYYEKALELDPD---NADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYDE 77

                          90
                  ....*....|...
gi 1567504017  96 AFKDVQRCATLEP 108
Cdd:COG3063    78 ALAYLERALELDP 90
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 2-108 4.52e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 47.65  E-value: 4.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017   2 AEAEAMQLKEEGNQHFQLQDYKAATKSYSQALKLTKDKAllaTLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALY 81
Cdd:COG5010    50 LAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNP---ELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYS 126

                          90       100
                  ....*....|....*....|....*..
gi 1567504017  82 RRCQALEHLGKLDQAFKDVQRCATLEP 108
Cdd:COG5010   127 NLAALLLSLGQDDEAKAALQRALGTSP 153
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 13-110 1.38e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.80  E-value: 1.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017  13 GNQHFQLQDYKAATKSYSQALKLTKDKA----LLATLYrnraacgLKTESYVQAASDASRAIDINSSDIKALYRRCQALE 88
Cdd:COG2956   151 AELYLEQGDYDEAIEALEKALKLDPDCArallLLAELY-------LEQGDYEEAIAALERALEQDPDYLPALPRLAELYE 223

                          90       100
                  ....*....|....*....|..
gi 1567504017  89 HLGKLDQAFKDVQRCATLEPQN 110
Cdd:COG2956   224 KLGDPEEALELLRKALELDPSD 245
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 13-110 1.55e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.87  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017  13 GNQHFQLQDYKAATKSYSQALKLTKDkalLATLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQALEHLGK 92
Cdd:COG4783    45 GEILLQLGDLDEAIVLLHEALELDPD---EPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGR 121

                          90
                  ....*....|....*...
gi 1567504017  93 LDQAFKDVQRCATLEPQN 110
Cdd:COG4783   122 PDEAIAALEKALELDPDD 139
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
42-110 1.66e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 44.23  E-value: 1.66e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1567504017  42 LATLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQALEHLGKLDQAFKDVQRCATLEPQN 110
Cdd:COG0457     7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDD 75
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 15-121 7.95e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 39.97  E-value: 7.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017  15 QHFQLQDYKAATKSYSQALKLTKDKALLATLYRNRAACGLKTESYVQAASDASRAIDINSSDIK---ALYRRCQALEHLG 91
Cdd:COG1729     2 ALLKAGDYDEAIAAFKAFLKRYPNSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKapdALLKLGLSYLELG 81

                          90       100       110
                  ....*....|....*....|....*....|
gi 1567504017  92 KLDQAFKDVQRCATLEPQNQSFQETLRRLN 121
Cdd:COG1729    82 DYDKARATLEELIKKYPDSEAAKEARARLA 111
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 1-157 1.06e-03

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 42.66  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017   1 MAEAEAMQLKEEGNQHFQLQDYKAATKSYSQALKLtkDKALLATlYRNRAACGLKTESYVQAASDASRAIDINSSDIKAL 80
Cdd:TIGR00990 326 LGEKEAIALNLRGTFKCLKGKHLEALADLSKSIEL--DPRVTQS-YIKRASMNLELGDPDKAEEDFDKALKLNSEDPDIY 402

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017  81 YRRCQALEHLGKLDQAFKDVQRCATLEPQN----------QSFQETLRRLNTSIQEKLRvQFSTDSRVQTMF-EILLDRN 149
Cdd:TIGR00990 403 YHRAQLHFIKGEFAQAGKDYQKSIDLDPDFifshiqlgvtQYKEGSIASSMATFRRCKK-NFPEAPDVYNYYgELLLDQN 481


                  ....*...
gi 1567504017 150 SEADKLEK 157
Cdd:TIGR00990 482 KFDEAIEK 489
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
21-111 1.99e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 40.67  E-value: 1.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017  21 DYKAATKSYSQALKLTKDKALLATLYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQALEHLGKLDQAFKDV 100
Cdd:COG4785    51 AALAAAALAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDF 130

                          90
                  ....*....|.
gi 1567504017 101 QRCATLEPQNQ 111
Cdd:COG4785   131 DRALELDPDYA 141
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 16-120 3.42e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.48  E-value: 3.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017  16 HFQLQDYKAATKSYSQALKLTKDKALLatlYRNRAACGLKTESYVQAASDASRAIDINSSDIKALYRRCQALEHLGKLDQ 95
Cdd:COG2956   120 YEQEGDWEKAIEVLERLLKLGPENAHA---YCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEE 196

                          90       100
                  ....*....|....*....|....*
gi 1567504017  96 AFKDVQRCATLEPQNQSFQETLRRL 120
Cdd:COG2956   197 AIAALERALEQDPDYLPALPRLAEL 221
INSC_LBD cd21966
LGN-binding domain (LBD) of protein Inscuteable (INSC) and similar proteins; Inscuteable (INSC) ...
 87-288 6.47e-03

LGN-binding domain (LBD) of protein Inscuteable (INSC) and similar proteins; Inscuteable (INSC) functions as an adapter protein linking the Par polarity complex (composed of Par3, Par6 and protein kinase C iota) to the Gpsm1/Gpsm2 complex, and is involved in cell polarity and spindle orientation during mitosis. Par3 interacts with INSC which binds directly to Pins (partner of Insc, homolog of vertebrate LGN/Gpsm2 and AGS3/Gpsm1). Pins then associates with the heterotrimeric G proteins and NuMA, which interacts directly with the cell spindle to control the orientation of the spindle and the division plane of mitotic cells. INSC may regulate cell proliferation and differentiation in the developing nervous system, may play a role in the asymmetric division of fibroblasts, and may also participate in the process of stratification of the squamous epithelium. This model corresponds to the Leu-Gly-Asn Repeat-Enriched Protein (LGN)-binding domain (LBD) of INSC. It interacts with the tetratricopeptide repeat (TPR) motifs of LGN, also called G-protein-signaling modulator 2 (Gpsm2).


Pssm-ID: 439320 [Multi-domain]  Cd Length: 300  Bit Score: 39.55  E-value: 6.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017  87 LEHLGKLDQAFKdvqRCATLEPQNQSFQETLRRLNTSIQEKLRVQFSTDsrVQTMFEILLDRNSEADkLEKAANNLIVLS 166
Cdd:cd21966   114 LEICEELRTAAE---RSLGSKPNLEELLKLLTTLGQSFSKLVDLLLLKE--LQILVDSLEEPTSELS-LRAALSALTSLG 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1567504017 167 REEAGAERIF-QNNGM-ALLMQLLDTKRPELMLAAVRTLSGMCsshraratailhavridriCSLMAVESEEMSLAVcnl 244
Cdd:cd21966   188 LEGPHLCRLIaKEGGVrALLIVCRDCKSSSVRALALRALATVC-------------------CVPEAIRQFEKAGGI--- 245

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1567504017 245 lQAIIDALSDEDKQEHRGKEEALVL--------DSKKDLKQITNHLLDMLVS 288
Cdd:cd21966   246 -EILSDILTDESRSEPERSEAAGVLaqitspwiDDNHHLSGLIEHMEDLVKA 296
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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