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Conserved domains on  [gi|470406064|ref|XP_004335911|]
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cyclin, Nterminal domain containing protein [Acanthamoeba castellanii str. Neff]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 5-169 1.03e-48

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410228  Cd Length: 150  Bit Score: 161.61  E-value: 1.03e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064   5 AQSSHCRDWLFTSEDALRKRKQECNDKAFGKVIAQIDRQAAaklaeggdasieekrqkaiSARTLSIEEEDLIKKWYATK 84
Cdd:cd20524    1 HTSTQRKHWIFSSEEELAELRAEANEKAREKLKESLKEEDA-------------------EPKFLTPEEELLLVRYYEKK 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064  85 IREF-GQLGLPEKVLGTATIYFKRFFLSNAITHHDLRHIMLASIYLAAKVEEVVLPVDNIAGPVNAKK---EDVLAMEIP 160
Cdd:cd20524   62 LLEFcRAFKLPDSVLATALTYFKRFYLKNSVMEYHPKEIMLTCLYLACKVEEFNISIDQFVGNIKESEktaEIILEYELL 141


                 ....*....
gi 470406064 161 LLEGLQFDL 169
Cdd:cd20524  142 LLQGLNFHL 150
CYCLIN_CCNH_rpt2 cd20525
second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 172-291 4.95e-33

second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410229  Cd Length: 126  Bit Score: 120.09  E-value: 4.95e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064 172 HLPYNPLHGFIIDLKE--STSPPASPEKLQGRARRHINDLLITDAPFLYPPAQLALAALRKASEEEGYPLAEYMHSRFHT 249
Cdd:cd20525    1 HHPYRPLEGFLLDLKTrlPDLKAENLEKLYKEAREFLNRSLLTDAPLLYPPSQIALAALLLAASEAGIDVEEYLSEKLPG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 470406064 250 NAG---YDQLRLNVEAIQKYIME-GGQMDVSRVKKIDRKLKKCLNP 291
Cdd:cd20525   81 SEEseeLEKLLEIIREIKKLVKKyEGPPDKEEVKALDKKLKKCRNP 126
 
Name Accession Description Interval E-value
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 5-169 1.03e-48

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 161.61  E-value: 1.03e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064   5 AQSSHCRDWLFTSEDALRKRKQECNDKAFGKVIAQIDRQAAaklaeggdasieekrqkaiSARTLSIEEEDLIKKWYATK 84
Cdd:cd20524    1 HTSTQRKHWIFSSEEELAELRAEANEKAREKLKESLKEEDA-------------------EPKFLTPEEELLLVRYYEKK 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064  85 IREF-GQLGLPEKVLGTATIYFKRFFLSNAITHHDLRHIMLASIYLAAKVEEVVLPVDNIAGPVNAKK---EDVLAMEIP 160
Cdd:cd20524   62 LLEFcRAFKLPDSVLATALTYFKRFYLKNSVMEYHPKEIMLTCLYLACKVEEFNISIDQFVGNIKESEktaEIILEYELL 141


                 ....*....
gi 470406064 161 LLEGLQFDL 169
Cdd:cd20524  142 LLQGLNFHL 150
ccl1 TIGR00569
cyclin ccl1; All proteins in this family for which functions are known are cyclins that are ...
 4-308 1.99e-48

cyclin ccl1; All proteins in this family for which functions are known are cyclins that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, StanfordUniversity). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129660 [Multi-domain]  Cd Length: 305  Bit Score: 166.16  E-value: 1.99e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064    4 FAQSSHCRDWLFTSEDALRKRKQECNDKafgkviaqidRQAAAKlaeggdasiEEKRQKAISARTLSIEEEDLIKKWYAT 83
Cdd:TIGR00569   1 YRNSSQKRHWTFTSEEQLQEKRADANAK----------FREAHE---------EEEKVLEAKPIFLTPEEELDLVKYYEK 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064   84 KIREFGQ---LGLPEKVLGTATIYFKRFFLSNAITHHDLRHIMLASIYLAAKVEEVVLPVD----NIAGPVNAKKEDVLA 156
Cdd:TIGR00569  62 RLLDFCSafkPTMPTSVVGTAIMYFKRFYLNNSVMEYHPKIIMLTCVFLACKVEEFNVSIDqfvgNLKETPLKALEQVLE 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064  157 MEIPLLEGLQFDLIVHLPYNPLHGFIIDLKESTSPPASPEKLQGRARRHINDLLITDAPFLYPPAQLALAALRKASEEEG 236
Cdd:TIGR00569 142 YELLLIQQLNFHLIVHNPYRPLEGFLIDIKTRLPGLENPEYLRKHADKFLNRTLLTDAYLLYTPSQIALAAILHTASRAG 221

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 470406064  237 YPLAEYMHSRFHTNAGYDQLRLNVEA---IQKYIMEGGQMDVSRVKKIDRKLKKCLNPEFIPGTEEYAKRREREQ 308
Cdd:TIGR00569 222 LNMESYLTEQLSVPGNREELPQLIDImreLRILVKKYEEPRSEKVAALKKKLDECHSIEENLSSVKIRKRKGYED 296
CYCLIN_CCNH_rpt2 cd20525
second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 172-291 4.95e-33

second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410229  Cd Length: 126  Bit Score: 120.09  E-value: 4.95e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064 172 HLPYNPLHGFIIDLKE--STSPPASPEKLQGRARRHINDLLITDAPFLYPPAQLALAALRKASEEEGYPLAEYMHSRFHT 249
Cdd:cd20525    1 HHPYRPLEGFLLDLKTrlPDLKAENLEKLYKEAREFLNRSLLTDAPLLYPPSQIALAALLLAASEAGIDVEEYLSEKLPG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 470406064 250 NAG---YDQLRLNVEAIQKYIME-GGQMDVSRVKKIDRKLKKCLNP 291
Cdd:cd20525   81 SEEseeLEKLLEIIREIKKLVKKyEGPPDKEEVKALDKKLKKCRNP 126
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 61-239 1.38e-27

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 110.21  E-value: 1.38e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064  61 QKAISARTLSIEEEDLIKK------WYATKIREFG-QLGLPEKVLGTATIYFKRFFLSNAITHHDLRHIMLASIYLAAKV 133
Cdd:COG5333   22 QNAIELDLLVLEPELTLEKelnlviYYLKLIMDLCtRLNLPQTVLATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKV 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064 134 EEVvlPVD-----NIAGPVNAKK-----EDVLAMEIPLLEGLQFDLIVHLPYNPLHGFIIDLKEStsppaSPEKLQGRAR 203
Cdd:COG5333  102 EDT--PRDisiesFEARDLWSEEpkssrERILEYEFELLEALDFDLHVHHPYKYLEGFLKDLQEK-----DKYKLLQIAW 174

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 470406064 204 RHINDLLITDAPFLYPPAQLALAALRKASEEEGYPL 239
Cdd:COG5333  175 KIINDALRTDLCLLYPPHIIALAALLIACEVLGMPI 210
Cyclin_C_2 pfam16899
Cyclin C-terminal domain; Cyclins contain two domains of similar all-alpha fold, this family ...
 174-257 1.15e-16

Cyclin C-terminal domain; Cyclins contain two domains of similar all-alpha fold, this family corresponds with the C-terminal domain of some cyclins including cyclin C and cyclin H.


Pssm-ID: 465303  Cd Length: 98  Bit Score: 74.88  E-value: 1.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064  174 PYNPLHGFIIDLKE-STSPPASPEKLQGRARRHINDLLITDAPFLYPPAQLALAALRKASEeegyPLAE-YMHSRFHTNA 251
Cdd:pfam16899   2 PFRPLEGFLLDLKTrPPLLEDRIESLYKRAREILKSALLTDAYFLYTPSQIALAALLLADS----PLAEfYLTEKFGLPE 77


                  ....*.
gi 470406064  252 GYDQLR 257
Cdd:pfam16899  78 DRETKL 83
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 85-163 5.37e-10

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 55.29  E-value: 5.37e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064    85 IREFG-QLGLPEKVLGTATIYFKRFFLSNAITHHDLRHIMLASIYLAAKVEEVVLPVDNIAG-PVNAKKEDVLAMEIPLL 162
Cdd:smart00385   3 LRRVCkALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHyTGYFTEEEILRMERLLL 82


                   .
gi 470406064   163 E 163
Cdd:smart00385  83 E 83
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 100-169 2.56e-06

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 46.36  E-value: 2.56e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 470406064  100 TATIYFKRFFLSNAITHHDLRHIMLASIYLAAKVEEVVLP-VDNIA-GPVNA-KKEDVLAMEIPLLEGLQFDL 169
Cdd:pfam00134  54 LAVNYLDRFLSKKSVPKNKLQLVGVTCLFIAAKYEEIYPPtVEDLVyITDNAyTREEILRMERLILETLNFDL 126
 
Name Accession Description Interval E-value
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 5-169 1.03e-48

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 161.61  E-value: 1.03e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064   5 AQSSHCRDWLFTSEDALRKRKQECNDKAFGKVIAQIDRQAAaklaeggdasieekrqkaiSARTLSIEEEDLIKKWYATK 84
Cdd:cd20524    1 HTSTQRKHWIFSSEEELAELRAEANEKAREKLKESLKEEDA-------------------EPKFLTPEEELLLVRYYEKK 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064  85 IREF-GQLGLPEKVLGTATIYFKRFFLSNAITHHDLRHIMLASIYLAAKVEEVVLPVDNIAGPVNAKK---EDVLAMEIP 160
Cdd:cd20524   62 LLEFcRAFKLPDSVLATALTYFKRFYLKNSVMEYHPKEIMLTCLYLACKVEEFNISIDQFVGNIKESEktaEIILEYELL 141


                 ....*....
gi 470406064 161 LLEGLQFDL 169
Cdd:cd20524  142 LLQGLNFHL 150
ccl1 TIGR00569
cyclin ccl1; All proteins in this family for which functions are known are cyclins that are ...
 4-308 1.99e-48

cyclin ccl1; All proteins in this family for which functions are known are cyclins that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, StanfordUniversity). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129660 [Multi-domain]  Cd Length: 305  Bit Score: 166.16  E-value: 1.99e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064    4 FAQSSHCRDWLFTSEDALRKRKQECNDKafgkviaqidRQAAAKlaeggdasiEEKRQKAISARTLSIEEEDLIKKWYAT 83
Cdd:TIGR00569   1 YRNSSQKRHWTFTSEEQLQEKRADANAK----------FREAHE---------EEEKVLEAKPIFLTPEEELDLVKYYEK 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064   84 KIREFGQ---LGLPEKVLGTATIYFKRFFLSNAITHHDLRHIMLASIYLAAKVEEVVLPVD----NIAGPVNAKKEDVLA 156
Cdd:TIGR00569  62 RLLDFCSafkPTMPTSVVGTAIMYFKRFYLNNSVMEYHPKIIMLTCVFLACKVEEFNVSIDqfvgNLKETPLKALEQVLE 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064  157 MEIPLLEGLQFDLIVHLPYNPLHGFIIDLKESTSPPASPEKLQGRARRHINDLLITDAPFLYPPAQLALAALRKASEEEG 236
Cdd:TIGR00569 142 YELLLIQQLNFHLIVHNPYRPLEGFLIDIKTRLPGLENPEYLRKHADKFLNRTLLTDAYLLYTPSQIALAAILHTASRAG 221

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 470406064  237 YPLAEYMHSRFHTNAGYDQLRLNVEA---IQKYIMEGGQMDVSRVKKIDRKLKKCLNPEFIPGTEEYAKRREREQ 308
Cdd:TIGR00569 222 LNMESYLTEQLSVPGNREELPQLIDImreLRILVKKYEEPRSEKVAALKKKLDECHSIEENLSSVKIRKRKGYED 296
CYCLIN_CCNH_rpt2 cd20525
second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 172-291 4.95e-33

second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410229  Cd Length: 126  Bit Score: 120.09  E-value: 4.95e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064 172 HLPYNPLHGFIIDLKE--STSPPASPEKLQGRARRHINDLLITDAPFLYPPAQLALAALRKASEEEGYPLAEYMHSRFHT 249
Cdd:cd20525    1 HHPYRPLEGFLLDLKTrlPDLKAENLEKLYKEAREFLNRSLLTDAPLLYPPSQIALAALLLAASEAGIDVEEYLSEKLPG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 470406064 250 NAG---YDQLRLNVEAIQKYIME-GGQMDVSRVKKIDRKLKKCLNP 291
Cdd:cd20525   81 SEEseeLEKLLEIIREIKKLVKKyEGPPDKEEVKALDKKLKKCRNP 126
CYCLIN_AcCycH_rpt1 cd20585
first cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH ...
 4-169 8.25e-31

first cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH associates with and activates the cyclin-dependent kinases, CDK-2 and CDK-3. CycH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410288  Cd Length: 170  Bit Score: 115.70  E-value: 8.25e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064   4 FAQSSHCRDWLFTSEDaLRKRKQECNDKAFGKVIAQIDRQAAAKlAEGGDASIEEKRQKAISA----RTLSIEEEDLIKK 79
Cdd:cd20585    2 FATSTHRQRWIFTPQD-LTEKREAANQRAVDALQQCGATRVEAQ-AAGSLGGGAEVGGSNGKAaklpEPLSADEELLMLK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064  80 WYATKIREF-GQLGLPEKVLGTATIYFKRFFLSNAITHHDLRHIMLASIYLAAKVEEVVLPVDNIAGPVNAKKEDVLAME 158
Cdd:cd20585   80 YYEQKIQEVcRALRLPNKIQATALLYFKRFYLQWSVMEHDPKRIMLTCIYLACKVEEYHVSAEELGKGIQQDHQLILKNE 159

                        170
                 ....*....|.
gi 470406064 159 IPLLEGLQFDL 169
Cdd:cd20585  160 LALLQGLNFDL 170
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 61-239 1.38e-27

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 110.21  E-value: 1.38e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064  61 QKAISARTLSIEEEDLIKK------WYATKIREFG-QLGLPEKVLGTATIYFKRFFLSNAITHHDLRHIMLASIYLAAKV 133
Cdd:COG5333   22 QNAIELDLLVLEPELTLEKelnlviYYLKLIMDLCtRLNLPQTVLATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKV 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064 134 EEVvlPVD-----NIAGPVNAKK-----EDVLAMEIPLLEGLQFDLIVHLPYNPLHGFIIDLKEStsppaSPEKLQGRAR 203
Cdd:COG5333  102 EDT--PRDisiesFEARDLWSEEpkssrERILEYEFELLEALDFDLHVHHPYKYLEGFLKDLQEK-----DKYKLLQIAW 174

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 470406064 204 RHINDLLITDAPFLYPPAQLALAALRKASEEEGYPL 239
Cdd:COG5333  175 KIINDALRTDLCLLYPPHIIALAALLIACEVLGMPI 210
CYCLIN_AcCycH_rpt2 cd20586
second cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; ...
 172-291 7.69e-18

second cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH associates with and activates the cyclin-dependent kinases, CDK-2 and CDK-3. CycH contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410289 [Multi-domain]  Cd Length: 132  Bit Score: 79.01  E-value: 7.69e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064 172 HLPYNPLHGFIIDLKESTSPPASPE--KLQgRARR----HINDLLITDAPFLYPPAQLALAALRKASEE------EGYpl 239
Cdd:cd20586    1 YAPYRALEGFVQDLEEFLAAGSGPDsqGLQ-ELRKaalaAVDKLMLTDAPLLYPPGQLALAALRSANKAkggvdfDRY-- 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 470406064 240 AEYMHSRFHTNAG---YDQLRLNVEAIQKYIMEGGQMDVSRVKKIDRKLKKCLNP 291
Cdd:cd20586   78 LERVAARAASKMPddpAAALTAVLDEIEYLVSEGARPEVAEVKEIDRKLKECRAP 132
Cyclin_C_2 pfam16899
Cyclin C-terminal domain; Cyclins contain two domains of similar all-alpha fold, this family ...
 174-257 1.15e-16

Cyclin C-terminal domain; Cyclins contain two domains of similar all-alpha fold, this family corresponds with the C-terminal domain of some cyclins including cyclin C and cyclin H.


Pssm-ID: 465303  Cd Length: 98  Bit Score: 74.88  E-value: 1.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064  174 PYNPLHGFIIDLKE-STSPPASPEKLQGRARRHINDLLITDAPFLYPPAQLALAALRKASEeegyPLAE-YMHSRFHTNA 251
Cdd:pfam16899   2 PFRPLEGFLLDLKTrPPLLEDRIESLYKRAREILKSALLTDAYFLYTPSQIALAALLLADS----PLAEfYLTEKFGLPE 77


                  ....*.
gi 470406064  252 GYDQLR 257
Cdd:pfam16899  78 DRETKL 83
CYCLIN_CCNC_rpt1 cd20513
first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or ...
 81-165 1.34e-14

first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or SRB11, is a component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. It mediates stress-induced mitochondrial fission and apoptosis. CCNC contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410217 [Multi-domain]  Cd Length: 101  Bit Score: 69.16  E-value: 1.34e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064  81 YATKIREFG-QLGLPEKVLGTATIYFKRFFLSNAITHHDLRHIMLASIYLAAKVEEVVLPVDNIAG-----------PVN 148
Cdd:cd20513    5 FANFIQALGeRLKLRQRVIATAIVYFKRFYARNSFKDIDPRLVAPTCLYLASKVEECPSHARLIVAeakvlktkfsyEFP 84

                         90
                 ....*....|....*..
gi 470406064 149 AKKEDVLAMEIPLLEGL 165
Cdd:cd20513   85 YRVNDILECEFYLLEAL 101
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 85-158 2.96e-11

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 58.96  E-value: 2.96e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 470406064  85 IREFGQ-LGLPEKVLGTATIYFKRFFLSNAITHHDLRHIMLASIYLAAKVEEVVLPVDNIAGPVNAKKEDVLAME 158
Cdd:cd00043    6 IRRLCSkLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPRTLKEIAKVSGVSEKELRKAE 80
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 85-163 5.37e-10

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 55.29  E-value: 5.37e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064    85 IREFG-QLGLPEKVLGTATIYFKRFFLSNAITHHDLRHIMLASIYLAAKVEEVVLPVDNIAG-PVNAKKEDVLAMEIPLL 162
Cdd:smart00385   3 LRRVCkALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHyTGYFTEEEILRMERLLL 82


                   .
gi 470406064   163 E 163
Cdd:smart00385  83 E 83
CYCLIN_CCNL_rpt1 cd20532
first cyclin box found in cyclin-L (CCNL) family; The CCNL family includes two cyclins, CCNL1 ...
 69-135 2.85e-09

first cyclin box found in cyclin-L (CCNL) family; The CCNL family includes two cyclins, CCNL1 and CCNL2. CCNL1 is involved in the regulation of RNA polymerase II (pol II) transcription. It functions in association with cyclin-dependent kinases (CDKs). CCNL2 is a novel RNA polymerase II-associated cyclin involved in pre-mRNA splicing. It may induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410235 [Multi-domain]  Cd Length: 127  Bit Score: 54.87  E-value: 2.85e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 470406064  69 LSIEEEDLIKKWYATKIREFGQ-LGLPEKVLGTATIYFKRFFLSNAITHHDLRHIMLASIYLAAKVEE 135
Cdd:cd20532    3 IDEETEIDLRIYGCELIQDAGIlLKLPQVVMATAQVLFHRFYYRKSLRKFDVKIVAMACLFLASKIEE 70
CYCLIN_CCNK_rpt1 cd20530
first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase ...
 69-168 2.30e-08

first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase II-associated C-type cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. It is a regulatory subunit of cyclin-dependent kinases that mediates the activation of these target kinases. It plays a role in transcriptional regulation by controlling the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). CCNK contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410233 [Multi-domain]  Cd Length: 115  Bit Score: 51.85  E-value: 2.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064  69 LSIEEEDLIKKWYATKIREFGQ-LGLPEKVLGTATIYFKRFFLSNAITHHDLRHIMLASIYLAAKVEE------------ 135
Cdd:cd20530    2 IDPETEARYRREGARFIQDVGTkLGLPYDTIATGIVYFHRFYMFHSFKDFDRYVTAACCLFLAGKVEEtpkkckdiikta 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 470406064 136 -VVLPVDNIAGPVNAKKEDVLAMEIPLLEGLQFD 168
Cdd:cd20530   82 rSLLNDKQFAQFGDDPKEEVMVLERILLQTIKFD 115
CYCLIN_SpCG1C-like_rpt1 cd20545
first cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1) and similar ...
 90-169 4.56e-07

first cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1) and similar proteins; Cyclin pch1 is essential for progression through the whole cell cycle. It is a homolog of cyclin T; it forms a heterodimer with its partner kinase, cyclin-dependent kinase 9 (CDK9), that can phosphorylate both the pol II C-terminal domain (CTD) and the CTD of transcription elongation factor Spt5. Yeast Cdk9/Pch1, with mRNA capping enzyme Pct1, may also form an elongation checkpoint for mRNA quality control. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410248 [Multi-domain]  Cd Length: 116  Bit Score: 48.19  E-value: 4.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064  90 QLGLPEKVLGTATIYFKRFFLSNAITHHDLRHIMLASIYLAAKVEEVVLPVDNIA---GPVNAKKED------------- 153
Cdd:cd20545   18 RLKLPQTTLFTAATYFHRFYMRNSLKKYHYYEIAATCLFLATKVEESGRKLRDIViacAKVAQKNPNlvideqskevwrw 97

                         90
                 ....*....|....*....
gi 470406064 154 ---VLAMEIPLLEGLQFDL 169
Cdd:cd20545   98 rdsILYNEEVLLETLCFDL 116
CYCLIN_ScCTK2-like_rpt1 cd20547
first cyclin box found in Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2) and similar ...
 90-137 9.27e-07

first cyclin box found in Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2) and similar proteins; CTK2, also called CTD kinase subunit beta, CTDK-I subunit beta, or CTD kinase 38 kDa subunit, is the cyclin subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. CTK2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410250 [Multi-domain]  Cd Length: 110  Bit Score: 46.96  E-value: 9.27e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 470406064  90 QLGLPEKVLGTATIYFKRFFLSNAITHHDLRHIMLASIYLAAKVEEVV 137
Cdd:cd20547   15 KLKFPRRTLGTAMLLYQRFHLFNPFTDSSNYEVALACLFLASKIEDTQ 62
CYCLIN_AtCycC_rpt1 cd20571
first cyclin box found in Arabidopsis thaliana C-type cyclins (CycCs) and similar proteins; ...
 72-167 1.45e-06

first cyclin box found in Arabidopsis thaliana C-type cyclins (CycCs) and similar proteins; Plant CycCs are the cognate cyclin partners of cyclin-dependent kinase CDK8. They may be involved in cell cycle control. CycCs contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410274 [Multi-domain]  Cd Length: 107  Bit Score: 46.39  E-value: 1.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064  72 EEEDLIKKWYATKIREFGQ-LGLPEKVLGTATIYFKRFFLSNAITHHDLRHIMLASIYLAAKVEEVVLPVDNIA------ 144
Cdd:cd20571    1 EDVKLIKIHMSNYIKKLAQhIKVRQRVVATAITYFRRVYTRKSFTEYDPRLVAPTCLYLASKAEESTVQAKLLVfymkrl 80

                         90       100
                 ....*....|....*....|....*.
gi 470406064 145 GPVNAKK---EDVLAMEIPLLEGLQF 167
Cdd:cd20571   81 YADEYHRyeiKDILEMEMKLLEALDY 106
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 100-169 2.56e-06

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 46.36  E-value: 2.56e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 470406064  100 TATIYFKRFFLSNAITHHDLRHIMLASIYLAAKVEEVVLP-VDNIA-GPVNA-KKEDVLAMEIPLLEGLQFDL 169
Cdd:pfam00134  54 LAVNYLDRFLSKKSVPKNKLQLVGVTCLFIAAKYEEIYPPtVEDLVyITDNAyTREEILRMERLILETLNFDL 126
CYCLIN_AcCycT_rpt1 cd20587
first cyclin box found in Arabidopsis thaliana T-type cyclins (CycTs) and similar proteins; ...
 69-143 5.61e-06

first cyclin box found in Arabidopsis thaliana T-type cyclins (CycTs) and similar proteins; CycTs associate with their partner cyclin-dependent kinases (CDKs) to trigger their kinase activity. CycTs show high sequence similarity with metazoan cyclin-K (CCNK). CycTs contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410290 [Multi-domain]  Cd Length: 124  Bit Score: 45.20  E-value: 5.61e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 470406064  69 LSIEEEDLIKKWYATKIREFGQ-LGLPEKVLGTATIYFKRFFLSNAITHHDLRHIMLASIYLAAKVEEVVLPVDNI 143
Cdd:cd20587    3 IDLKKETYLRKSYCTFLQDLGMrLKVPQVTIATAIVFCHRFFLRQSHAKNDRQTIATVCMFLAGKVEETPRPLKDV 78
CYCLIN_CCNL2_rpt1 cd20590
first cyclin box found in cyclin-2 (CCNL2) and similar proteins; CCNL2 is a novel RNA ...
 91-135 6.12e-06

first cyclin box found in cyclin-2 (CCNL2) and similar proteins; CCNL2 is a novel RNA polymerase II-associated cyclin that is involved in pre-mRNA splicing. It may induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. CCNL2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410293 [Multi-domain]  Cd Length: 156  Bit Score: 45.77  E-value: 6.12e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 470406064  91 LGLPEKVLGTATIYFKRFFLSNAITHHDLRHIMLASIYLAAKVEE 135
Cdd:cd20590   58 LRLPQVAMATGQVLFQRFFYTKSFVKHSMEHVSMACVHLASKIEE 102
CYCLIN_CCNM_CCNQ_rpt1 cd20534
first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ...
 85-138 9.59e-06

first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410237 [Multi-domain]  Cd Length: 110  Bit Score: 44.08  E-value: 9.59e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 470406064  85 IREFGQ-LGLPEKVLGTATIYFKRFFLSNAITHHDLRHIMLASIYLAAKVEEVVL 138
Cdd:cd20534    9 IREAGLkLELSSVTIATACVLYHRFYRELSLEDYDPYLVAMACLYLAGKAEEQPR 63
CYCLIN_CCNT_rpt1 cd20538
first cyclin box found in cyclin-T (CCNT) family; The CCNT family includes two C-type cyclins, ...
 82-135 1.29e-04

first cyclin box found in cyclin-T (CCNT) family; The CCNT family includes two C-type cyclins, cyclin-T1 (CCNT1) and cyclin-T2 (CCNT2), both of which are regulatory subunits of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410241 [Multi-domain]  Cd Length: 137  Bit Score: 41.61  E-value: 1.29e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 470406064  82 ATKIREFGQ-LGLPEKVLGTATIYFKRFFLSNAITHHDLRHIMLASIYLAAKVEE 135
Cdd:cd20538   32 ANLIQEMGQrLQVSQLCINTAIVYMHRFYMFHSFTKFHRNSIAAAALFLAAKVEE 86
CYCLIN_CCNL1_rpt1 cd20589
first cyclin box found in cyclin-L1 (CCNL1) and similar proteins; CCNL1 is an L-type cyclin ...
 91-135 3.35e-04

first cyclin box found in cyclin-L1 (CCNL1) and similar proteins; CCNL1 is an L-type cyclin involved in the regulation of RNA polymerase II (pol II) transcription. It functions in association with cyclin-dependent kinases (CDKs). CCNL1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410292 [Multi-domain]  Cd Length: 124  Bit Score: 40.11  E-value: 3.35e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 470406064  91 LGLPEKVLGTATIYFKRFFLSNAITHHDLRHIMLASIYLAAKVEE 135
Cdd:cd20589   26 LRLPQVAMATGQVLFQRFFYSKSFVKHSMEIVAMACINLASKIEE 70
CYCLIN_CCNC_rpt2 cd20514
second cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or ...
 174-232 4.98e-04

second cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or SRB11, is a component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. It mediates stress-induced mitochondrial fission and apoptosis. CCNC contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410218 [Multi-domain]  Cd Length: 92  Bit Score: 38.75  E-value: 4.98e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 470406064 174 PYNPLHGFIIDLKESTSppaspekLQGRARRHINDLLITDAPFLYPPAQLALAALRKAS 232
Cdd:cd20514    2 PYRPLTQYVQDAGLDDE-------LLPLAWRIVNDSYRTDVCLLYPPYLIALACLHMAC 53
CYCLIN_CCNT2_rpt1 cd20596
first cyclin box found in cyclin-T2 (CCNT2); CCNT2, also termed CycT2, is a regulatory subunit ...
 82-135 1.56e-03

first cyclin box found in cyclin-T2 (CCNT2); CCNT2, also termed CycT2, is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). CCNT2 contains two cyclin boxs. The model responds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410299 [Multi-domain]  Cd Length: 139  Bit Score: 38.49  E-value: 1.56e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 470406064  82 ATKIREFGQ-LGLPEKVLGTATIYFKRFFLSNAITHHDLRHIMLASIYLAAKVEE 135
Cdd:cd20596   34 ANLIQDMGQrLNVSQLTINTAIVYMHRFYMHHSFTKFHRNIISPTALFLAAKVEE 88
CYCLIN_CCNT1_rpt1 cd20595
first cyclin box found in cyclin-T1 (CCNT1); CCNT1, also termed CycT1, is a host factor ...
 58-135 2.46e-03

first cyclin box found in cyclin-T1 (CCNT1); CCNT1, also termed CycT1, is a host factor essential for HIV-1 replication in CD4 T cells and macrophages. It is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). CCNT1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410298 [Multi-domain]  Cd Length: 138  Bit Score: 38.11  E-value: 2.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064  58 EKRQKAISART-LSIEEEDLIKKWYATKIREFGQ-LGLPEKVLGTATIYFKRFFLSNAITHHDLRHIMLASIYLAAKVEE 135
Cdd:cd20595    8 EQLENSPSRRFgVDPDKELSYRQQAANLLQDMGQrLNVSQLTINTAIVYMHRFYMIQSFTQFHRNSVAPAALFLAAKVEE 87
CYCLIN_CABLES1 cd20602
cyclin box found in CDK5 and ABL1 enzyme substrate 1 (CABLES1); CABLES1, also called ...
 84-174 2.98e-03

cyclin box found in CDK5 and ABL1 enzyme substrate 1 (CABLES1); CABLES1, also called interactor with CDK3 1 (Ik3-1), is a cyclin-dependent kinase binding protein that enhances cyclin-dependent kinase tyrosine phosphorylation by non-receptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. CABLES1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410305  Cd Length: 132  Bit Score: 37.72  E-value: 2.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 470406064  84 KIREFGQ--LGLPEKVLGTATIYFKRFFLSNAITHHDLRHIMLASIYLAAKV------EEVVLPVDNIAGPVNAKKEDVL 155
Cdd:cd20602   21 EMRKLAQeeCGYEEPTVAMAFVYFEKLALKGKLNKQNRKLCAGACVLLAAKIgsdlkkHEVKHLIDKLEEKFRLNRRELI 100

                         90
                 ....*....|....*....
gi 470406064 156 AMEIPLLEGLQFDLivHLP 174
Cdd:cd20602  101 AFEFPVLVALEFAL--HLP 117
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 104-168 5.82e-03

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 36.62  E-value: 5.82e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 470406064 104 YFKRFFLSNAITHHDLRHIMLASIYLAAKVEEVVLP--------VDNiagpvNAKKEDVLAMEIPLLEGLQFD 168
Cdd:cd20562   69 YIDRFLSGNYVNRQRLQLLGVSCMLIASKYEEICAPqveefcyiTDN-----TYTKQEVLEMEIDVLNALQFE 136
CYCLIN_AcCycL_rpt1 cd20591
first cyclin box found in Arabidopsis thaliana L-type cyclins (CycL) and similar proteins; ...
 91-135 7.52e-03

first cyclin box found in Arabidopsis thaliana L-type cyclins (CycL) and similar proteins; Cyclin-L1-1 (CycL1), also called arginine-rich cyclin 1 (AtRCY1), or protein MODIFIER OF SNC1 12, is the cognate cyclin for cyclin-dependent kinase G1 (CDKG1). It is involved in regulation of DNA methylation and transcriptional silencing. It is required for synapsis and male meiosis, and for the proper splicing of specific resistance (R) genes. L-type cyclins contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410294 [Multi-domain]  Cd Length: 128  Bit Score: 36.35  E-value: 7.52e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 470406064  91 LGLPEKVLGTATIYFKRFFLSNAITHHDLRHIMLASIYLAAKVEE 135
Cdd:cd20591   29 LKLPQAVMATGQVLFQRFYCKKSFARFNVKRVAASCVWLAAKLEE 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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