NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|530408236|ref|XP_005255427|]
View 

polycystin-1 isoform X10 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 1-1713 0e+00

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 3222.97  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236     1 MNRMQGLQVSTVPAVLSPNATLALTAGVLVDSAVEVAFLWTFGDGEQALHQFQPPYNESFPVPDPSVAQVLVEHNVMHTY 80
Cdd:TIGR00864  977 LNPMQGLQVKGVPAVLPPGATLALTAGVLIDMAVEAAFLWSFGDGEQALFEFKPPYNESFPCPDPSPAQVLLEHNVMHIY 1056

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236    81 AAPGEYLLTVLASNAFENLTQQVPVSVRASLPSVAVGVSDGVLVAGRPVTFYPHPLPSPGGVLYTWDFGDGSPVLTQSQP 160
Cdd:TIGR00864 1057 AAPGEYLATVLASNAFENISQQINMSVRAILPRVAIGTEDGLLLAGKPADFEAHPLPSPGGIHYEWDFGDGSALLQGRQP 1136

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   161 AANHTYASRGTYHVRLEVNNTVSGAAAQADVRVFEELRGLSVDMSLAVEQGAPVVVSAAVQTGDNITWTFDMGDGTVLSG 240
Cdd:TIGR00864 1137 AAAHTFAKRGPFHVCLEVNNTISGAAACADMFAFEEIEGLSADMSLATELGAATTVRAALQSGDNITWTFDMGDGKSLSG 1216

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   241 PEATVEHVYLRAQNCTVTVGAASPAGHLARSLHVLVFVLEVLRVEPAACIPTQPDARLTAYVTGNPAHYLFDWTFGDGSS 320
Cdd:TIGR00864 1217 PEATVEHKYAKAGNCTVNIGAANAAGHGARIIHVEVFVFEVAGIEPAACIGEHADANFRARVSGNAAHYLFDWSFGDGSP 1296

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   321 NTTVRGCPTVTHNFTRSGTFPLALVLSSRVNRAHYFTSICVEPEVGNVTLQPERQFVQLGDEAWLVACAWPPFPYRYTWD 400
Cdd:TIGR00864 1297 NETHHGCPGISHNFRGNGTFPLALTISSGVNKAHFFTQICVEPELGKISLQAEKQFFALGDEAQFQACAEPEFNYRYEWD 1376

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   401 FGTEEAAPTRARGPEVTFIYRDPGSYLVTVTASNNISAANDSALVEVQEPVLVTSIKVNGSLG--LELQQPYLFSAVGRG 478
Cdd:TIGR00864 1377 FGGEEAAPLPAAGAEVTFIYNDPGCYLVTVAASNNISAANDSALIEVLEPVGATSFKHNGSHGnnLELGQPYLFSAFGRA 1456

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   479 RPASYLWDLGDGGWLEGPEVTHAYNSTGDFTVRVAGWNEVSRSEAWLNVTVKRRVRGLVVNASRTVVPLNGSVSFSTSLE 558
Cdd:TIGR00864 1457 RNASYLWDFGDGGLLEGPEILHAFNSPGDFNIRLAAANEVGKNEATLNVAVKARVRGLTINASLTNVPLNGSVHFEAHLD 1536

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   559 AGSDVRYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIVTAENEVGSAQDSIFVYVLQLIEGLQVVGG------------- 625
Cdd:TIGR00864 1537 AGDDVRFSWILCDHCTPIFGGNTIFYTFRSVGTFNIIVTAENDVGAAQASIFLFVLQEIEGLQILGEtaegggggvqeld 1616

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   626 GRYFPTNHTVQLQAVVRDGTNVSYSWTAWRD---RGPALAGSGKGFSLTVLEAGTYHVQLRATNMLGSAWADCTMDFVEP 702
Cdd:TIGR00864 1617 GCYFETNHTVQFHAGFKDGTNLSFSWNAILDnepDGPAFAGSGKGAKLNPLEAGPCDIFLQAANLLGQATADCTIDFLEP 1696

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   703 VGWLMVAASPNPAAVNTSVTLSAELAGGSGVVYTWSLEEGLSWETSEPFTTHSFPTPGLHLVTMTAGNPLGSANATVEVD 782
Cdd:TIGR00864 1697 AGNLMLAASDNPAAVNALINLSAELAEGSGLQYRWFLEEGDDLETSEPFMSHSFPSAGLHLVTMKAFNELGSANASEEVD 1776

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   783 VQVPVSGLSIRASEPGGS-FVAAGSSVPFWGQLATGTNVSWCWAVPGGSSKRGPHVTMVFPDAGTFSIRLNASNAVSWVS 861
Cdd:TIGR00864 1777 VQEPISGLKIRAADAGEQnFFAADSSVCFQGELATGTNVSWCWAIDGGSSKMGKHACMTFPDAGTFAIRLNASNAVSGKS 1856

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   862 ATYNLTAEEPIVGLVLWASSKVVAPGQLVHFQILLAAGSAVTFRLQVGGANPEVL-PGPRFSHSFPRVGDHVVSVRGKNH 940
Cdd:TIGR00864 1857 ASREFFAEEPIFGLELKASKKIAAIGEKVEFQILLAAGSAVNFRLQIGGAAPEVLqPGPRFSHSFPRVDDHMVNLRAKNE 1936

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   941 VSWAQAQVRIVVLEAVSGLQVPNCCEPGIATGTERNFTARVQRGSRVAYAWYFSLQKVQGDSLVILSGRDVTYTPVAAGL 1020
Cdd:TIGR00864 1937 VSCAQANLHIEVLEAVRGLQIPDCCAAGIATGEEKNFTANVQRGKPVAFAWTFDLHHLHGDSLVIHMGKDVSYTAEAAGL 2016

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1021 LEIQVRAFNALGSENRTLVLEVQDAVQYVALQSGP--CFTNRSAQFEAATSPSPRRVAYHWDFGDGSPGQDTDEPRAEHS 1098
Cdd:TIGR00864 2017 LEIQLGAFNALGAENITLQLEAQDALMDAALQAGPqdCFTNKMAQFEAATSPKPNFMACHWDFGDGSAGQDTDEPRAEHE 2096

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1099 YLRPGDYRVQVNASNLVSFFVAQATVTVQVLACREPEVDVVLPLQVLMRRSQRNYLEAHVDLRDCVTYQTEYRWEVYRTA 1178
Cdd:TIGR00864 2097 YLHPGDYRVQVNASNLVSFFSAHAEINVQVLACEEPEVDVVLALQLAIRRSQPNLLEAHVDLKDCLRYGAEYLWEILRAA 2176

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1179 SCQRPGRPARVALPG-------------VDVSRPRLVLPRLALPVGHYCFVFVVSFGDTPLTQSIQANVTVAPERLVPII 1245
Cdd:TIGR00864 2177 SCDNDGHFARGALNGatrsfpviplpaeVDVQRLQLSLPKLALAAGHYCFVFSLSFEDTPLKKAACANLGVAAARLMPII 2256

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1246 EGGSYRVWSDTRDLVLDGSESYDPNLEDGDQTPLSFHWACVASTQREAGGCALNFGPRG-SSTVTIPRERLAAGVEYTFS 1324
Cdd:TIGR00864 2257 EGGSYRVWSDTQDLQLDAEESYDPNLDDDDQSLLHFHWACQASSKGEAGCCALNFGLGGkGPTLGIPGEELAAGIEYTFK 2336

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1325 LTVWKAGRKEEATNQTVLIRSGRVPIVSLECVSCKAQAVYEVSRSSYVYLEGRCLNCSSGSKRGRWAARTFSNKTLVLDE 1404
Cdd:TIGR00864 2337 LSIGKAGMKEEATNQTVLIQSGHIPIVSLECVSCKAQALYEVSQNSYVYLEGRCLNCQSGFHRGRWAARTFQNDTLVLDE 2416

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1405 TTTSTGSAGMRLVLRRGVLRDGEGYTFTLTVLGRSGEEEGCASIRLSPNRPPLGGSCRLFPLG--------------AVH 1470
Cdd:TIGR00864 2417 SSTSTGSAGMNLVLRQGVLHDGEGYNFTLHVLDDSGDEEGAASIRLHHNMPPDGGECHLFPGGetgqehgdkedevwAIE 2496

                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1471 ALTTKVHFECTGWHDAEDAGAPLVYALLLRRCRQGHCEEFCVYKGSLSSYGAVLPPGFR-PHFEVGLAVVVQDQLGAAVV 1549
Cdd:TIGR00864 2497 ALLDKVHFECSGWHDAEDAEAPLLYALLLNRCRDDHCEEFCVYKGSLPEHGAFLPPGFRsAHFEVGLAITVEDHLGAAIR 2576

                         1610      1620      1630      1640      1650      1660      1670      1680
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1550 ALNRSLAITLPEPNGSATGLTVWLHGLTASVLPGLLRQADPQHVIEYSLALVTVLNEYERALDVAAEPKHERQHRAQIRK 1629
Cdd:TIGR00864 2577 ALNKSIAITLPDPNGEASGLPHWLHDLIASKLKGLLDQADFQHVIELSLALITVLNEYEQALDSAAEPKHERGHRAQIRK 2656

                         1690      1700      1710      1720      1730      1740      1750      1760
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1630 NITETLVSLRVHTVDDIQQIAAALAQCMGPSRELVCRSCLKQTLHKLEAMMLILQAETTAGTVTPTAIGDSILNITGDLI 1709
Cdd:TIGR00864 2657 NITEALTALDLHTVDDIQQIAAALAQCMAPSREFICEECLKQTLHKLEAMLEILQADTKAGIVTPTAIADNILNIMGDLI 2736


                   ....
gi 530408236  1710 HLAS 1713
Cdd:TIGR00864 2737 HLAS 2740
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 2103-2222 3.38e-57

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238850  Cd Length: 120  Bit Score: 194.42  E-value: 3.38e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236 2103 FKYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGD--RAFHRNSLDIFRIATPHSLGSVWKIRVWHDNKGLSPAW 2180
Cdd:cd01752     1 YLYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPekPIFERGSVDSFLLTTPFPLGELQSIRLWHDNSGLSPSW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 530408236 2181 FLQHVIVRDLQTARSAFFLVNDWLSVETEanGGLVEKEVLAA 2222
Cdd:cd01752    81 YLSRVIVRDLQTGKKWFFLCNDWLSVEEG--DGTVERTFPVA 120
Polycystin_dom super family cl48672
Polycystin domain; This domain represents the polycystin domain from group II of Transient ...
 2698-2876 1.16e-55

Polycystin domain; This domain represents the polycystin domain from group II of Transient receptor potential (TRP) channels (TRPP) including PKD1, PKD2, PKD2L and mucolipins. The polycystin domain display a sandwich-like shape with five beta-sheets in the tilted middle layer, three alpha-helices on one side and a large loop with two short antiparallel beta-sheets on the other.


The actual alignment was detected with superfamily member pfam20519:

Pssm-ID: 466668  Cd Length: 199  Bit Score: 193.02  E-value: 1.16e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  2698 AFLAITRSEELWPWMAHVLLPYVHGNQS------------SPELGPPRLRQVRLQEA--LYPDPPGPRVHTCSAAGGFST 2763
Cdd:pfam20519    1 GLLTVTDLDDIWDWLSSVLLPALHSNKTpsglpgsfiayeSLLLGVPRLRQLRVRNSscLVHDKFVREINECHAGYSPPS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  2764 SDY----DVGWESPHNGSGTW-AYSAPDLL-GAWSWGSCAVYDSGGYVQELGLSLEESRDRLRFLQLHNWLDNRSRAVFL 2837
Cdd:pfam20519   81 EDRklysALPYKPVHYGSKYWfIYTPPGLLmGYDHWGHLASYPSGGYVVLLPSSREESLKRLAYLQDNNWLDRGTRAVFV 160

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 530408236  2838 ELTRYSPAVGLHAAVTLRLEFPAAGRALAALSVRPFALR 2876
Cdd:pfam20519  161 DFTLYNADINLFCVVTLRVEFPPTGGVLPSPSVQSVKLL 199
PKD_channel super family cl37568
Polycystin cation channel; This family contains the cation channel region from group II of ...
 2877-3098 3.15e-43

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


The actual alignment was detected with superfamily member pfam08016:

Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 158.59  E-value: 3.15e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  2877 RLSAGLSLPLLT-SVCLLLFAVHFAVAEARTWHREGR------WRVLRLgawarwLLVALTAATALVRLAQLGAADRQWT 2949
Cdd:pfam08016    1 RYVTNRSLFILLcEIVFVVFFLYFVVEEILKIRKHRPsylrsvWNLLDL------AIVILSVVLIVLNIYRDFLADRLIK 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  2950 rFVRGRPRRFTSFDQVAQLSSAARGLAASLLFLLLVKAAQQLRFVRQWSVFGKTLCRALPELLGVTLGLVVLGVAYAQLA 3029
Cdd:pfam08016   75 -SVEASPVTFIDFDRVAQLDNLYRIILAFLVFLTWLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFG 153

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530408236  3030 ILLVSSCVDSLWSVAQALLVLCPgtglsTLCPAESWH--------LSPLLCVGLWALRLWGALRLGAVILRWRYHAL 3098
Cdd:pfam08016  154 YLLFGTQAPNFSNFVKSILTLFR-----TILGDFGYNeifsgnrvLGPLLFLTFVFLVIFILLNLFLAIINDSYVEV 225
GPS smart00303
G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin ...
 1996-2045 1.92e-10

G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin REJ and polycystin.


:

Pssm-ID: 197639  Cd Length: 49  Bit Score: 58.55  E-value: 1.92e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 530408236   1996 YTSLCQYFSEEDMVWRTEGLLPLEETSpRQAVCLTRHLTAFGASLFVPPS 2045
Cdd:smart00303    1 FNPICVFWDESSGEWSTRGCELLETNG-THTTCSCNHLTTFAVLMDVPPI 49
 
Name Accession Description Interval E-value
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 1-1713 0e+00

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 3222.97  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236     1 MNRMQGLQVSTVPAVLSPNATLALTAGVLVDSAVEVAFLWTFGDGEQALHQFQPPYNESFPVPDPSVAQVLVEHNVMHTY 80
Cdd:TIGR00864  977 LNPMQGLQVKGVPAVLPPGATLALTAGVLIDMAVEAAFLWSFGDGEQALFEFKPPYNESFPCPDPSPAQVLLEHNVMHIY 1056

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236    81 AAPGEYLLTVLASNAFENLTQQVPVSVRASLPSVAVGVSDGVLVAGRPVTFYPHPLPSPGGVLYTWDFGDGSPVLTQSQP 160
Cdd:TIGR00864 1057 AAPGEYLATVLASNAFENISQQINMSVRAILPRVAIGTEDGLLLAGKPADFEAHPLPSPGGIHYEWDFGDGSALLQGRQP 1136

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   161 AANHTYASRGTYHVRLEVNNTVSGAAAQADVRVFEELRGLSVDMSLAVEQGAPVVVSAAVQTGDNITWTFDMGDGTVLSG 240
Cdd:TIGR00864 1137 AAAHTFAKRGPFHVCLEVNNTISGAAACADMFAFEEIEGLSADMSLATELGAATTVRAALQSGDNITWTFDMGDGKSLSG 1216

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   241 PEATVEHVYLRAQNCTVTVGAASPAGHLARSLHVLVFVLEVLRVEPAACIPTQPDARLTAYVTGNPAHYLFDWTFGDGSS 320
Cdd:TIGR00864 1217 PEATVEHKYAKAGNCTVNIGAANAAGHGARIIHVEVFVFEVAGIEPAACIGEHADANFRARVSGNAAHYLFDWSFGDGSP 1296

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   321 NTTVRGCPTVTHNFTRSGTFPLALVLSSRVNRAHYFTSICVEPEVGNVTLQPERQFVQLGDEAWLVACAWPPFPYRYTWD 400
Cdd:TIGR00864 1297 NETHHGCPGISHNFRGNGTFPLALTISSGVNKAHFFTQICVEPELGKISLQAEKQFFALGDEAQFQACAEPEFNYRYEWD 1376

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   401 FGTEEAAPTRARGPEVTFIYRDPGSYLVTVTASNNISAANDSALVEVQEPVLVTSIKVNGSLG--LELQQPYLFSAVGRG 478
Cdd:TIGR00864 1377 FGGEEAAPLPAAGAEVTFIYNDPGCYLVTVAASNNISAANDSALIEVLEPVGATSFKHNGSHGnnLELGQPYLFSAFGRA 1456

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   479 RPASYLWDLGDGGWLEGPEVTHAYNSTGDFTVRVAGWNEVSRSEAWLNVTVKRRVRGLVVNASRTVVPLNGSVSFSTSLE 558
Cdd:TIGR00864 1457 RNASYLWDFGDGGLLEGPEILHAFNSPGDFNIRLAAANEVGKNEATLNVAVKARVRGLTINASLTNVPLNGSVHFEAHLD 1536

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   559 AGSDVRYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIVTAENEVGSAQDSIFVYVLQLIEGLQVVGG------------- 625
Cdd:TIGR00864 1537 AGDDVRFSWILCDHCTPIFGGNTIFYTFRSVGTFNIIVTAENDVGAAQASIFLFVLQEIEGLQILGEtaegggggvqeld 1616

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   626 GRYFPTNHTVQLQAVVRDGTNVSYSWTAWRD---RGPALAGSGKGFSLTVLEAGTYHVQLRATNMLGSAWADCTMDFVEP 702
Cdd:TIGR00864 1617 GCYFETNHTVQFHAGFKDGTNLSFSWNAILDnepDGPAFAGSGKGAKLNPLEAGPCDIFLQAANLLGQATADCTIDFLEP 1696

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   703 VGWLMVAASPNPAAVNTSVTLSAELAGGSGVVYTWSLEEGLSWETSEPFTTHSFPTPGLHLVTMTAGNPLGSANATVEVD 782
Cdd:TIGR00864 1697 AGNLMLAASDNPAAVNALINLSAELAEGSGLQYRWFLEEGDDLETSEPFMSHSFPSAGLHLVTMKAFNELGSANASEEVD 1776

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   783 VQVPVSGLSIRASEPGGS-FVAAGSSVPFWGQLATGTNVSWCWAVPGGSSKRGPHVTMVFPDAGTFSIRLNASNAVSWVS 861
Cdd:TIGR00864 1777 VQEPISGLKIRAADAGEQnFFAADSSVCFQGELATGTNVSWCWAIDGGSSKMGKHACMTFPDAGTFAIRLNASNAVSGKS 1856

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   862 ATYNLTAEEPIVGLVLWASSKVVAPGQLVHFQILLAAGSAVTFRLQVGGANPEVL-PGPRFSHSFPRVGDHVVSVRGKNH 940
Cdd:TIGR00864 1857 ASREFFAEEPIFGLELKASKKIAAIGEKVEFQILLAAGSAVNFRLQIGGAAPEVLqPGPRFSHSFPRVDDHMVNLRAKNE 1936

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   941 VSWAQAQVRIVVLEAVSGLQVPNCCEPGIATGTERNFTARVQRGSRVAYAWYFSLQKVQGDSLVILSGRDVTYTPVAAGL 1020
Cdd:TIGR00864 1937 VSCAQANLHIEVLEAVRGLQIPDCCAAGIATGEEKNFTANVQRGKPVAFAWTFDLHHLHGDSLVIHMGKDVSYTAEAAGL 2016

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1021 LEIQVRAFNALGSENRTLVLEVQDAVQYVALQSGP--CFTNRSAQFEAATSPSPRRVAYHWDFGDGSPGQDTDEPRAEHS 1098
Cdd:TIGR00864 2017 LEIQLGAFNALGAENITLQLEAQDALMDAALQAGPqdCFTNKMAQFEAATSPKPNFMACHWDFGDGSAGQDTDEPRAEHE 2096

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1099 YLRPGDYRVQVNASNLVSFFVAQATVTVQVLACREPEVDVVLPLQVLMRRSQRNYLEAHVDLRDCVTYQTEYRWEVYRTA 1178
Cdd:TIGR00864 2097 YLHPGDYRVQVNASNLVSFFSAHAEINVQVLACEEPEVDVVLALQLAIRRSQPNLLEAHVDLKDCLRYGAEYLWEILRAA 2176

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1179 SCQRPGRPARVALPG-------------VDVSRPRLVLPRLALPVGHYCFVFVVSFGDTPLTQSIQANVTVAPERLVPII 1245
Cdd:TIGR00864 2177 SCDNDGHFARGALNGatrsfpviplpaeVDVQRLQLSLPKLALAAGHYCFVFSLSFEDTPLKKAACANLGVAAARLMPII 2256

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1246 EGGSYRVWSDTRDLVLDGSESYDPNLEDGDQTPLSFHWACVASTQREAGGCALNFGPRG-SSTVTIPRERLAAGVEYTFS 1324
Cdd:TIGR00864 2257 EGGSYRVWSDTQDLQLDAEESYDPNLDDDDQSLLHFHWACQASSKGEAGCCALNFGLGGkGPTLGIPGEELAAGIEYTFK 2336

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1325 LTVWKAGRKEEATNQTVLIRSGRVPIVSLECVSCKAQAVYEVSRSSYVYLEGRCLNCSSGSKRGRWAARTFSNKTLVLDE 1404
Cdd:TIGR00864 2337 LSIGKAGMKEEATNQTVLIQSGHIPIVSLECVSCKAQALYEVSQNSYVYLEGRCLNCQSGFHRGRWAARTFQNDTLVLDE 2416

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1405 TTTSTGSAGMRLVLRRGVLRDGEGYTFTLTVLGRSGEEEGCASIRLSPNRPPLGGSCRLFPLG--------------AVH 1470
Cdd:TIGR00864 2417 SSTSTGSAGMNLVLRQGVLHDGEGYNFTLHVLDDSGDEEGAASIRLHHNMPPDGGECHLFPGGetgqehgdkedevwAIE 2496

                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1471 ALTTKVHFECTGWHDAEDAGAPLVYALLLRRCRQGHCEEFCVYKGSLSSYGAVLPPGFR-PHFEVGLAVVVQDQLGAAVV 1549
Cdd:TIGR00864 2497 ALLDKVHFECSGWHDAEDAEAPLLYALLLNRCRDDHCEEFCVYKGSLPEHGAFLPPGFRsAHFEVGLAITVEDHLGAAIR 2576

                         1610      1620      1630      1640      1650      1660      1670      1680
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1550 ALNRSLAITLPEPNGSATGLTVWLHGLTASVLPGLLRQADPQHVIEYSLALVTVLNEYERALDVAAEPKHERQHRAQIRK 1629
Cdd:TIGR00864 2577 ALNKSIAITLPDPNGEASGLPHWLHDLIASKLKGLLDQADFQHVIELSLALITVLNEYEQALDSAAEPKHERGHRAQIRK 2656

                         1690      1700      1710      1720      1730      1740      1750      1760
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1630 NITETLVSLRVHTVDDIQQIAAALAQCMGPSRELVCRSCLKQTLHKLEAMMLILQAETTAGTVTPTAIGDSILNITGDLI 1709
Cdd:TIGR00864 2657 NITEALTALDLHTVDDIQQIAAALAQCMAPSREFICEECLKQTLHKLEAMLEILQADTKAGIVTPTAIADNILNIMGDLI 2736


                   ....
gi 530408236  1710 HLAS 1713
Cdd:TIGR00864 2737 HLAS 2740
REJ pfam02010
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ...
 1156-1599 2.10e-132

REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.


Pssm-ID: 366875 [Multi-domain]  Cd Length: 448  Bit Score: 423.84  E-value: 2.10e-132
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1156 AHVDLRDCV-TYQTEYRWEVYRTASC---QRPGRPARVALPGVDvsrprlvLPRLALPVGHYCFVFVVSFGDTP-LTQSI 1230
Cdd:pfam02010    1 ASVELNGCFsAYTIDYLWSVFTVSSNlnlQTISSPKDLVLPQLT-------IPSGTLPYGTYVFTLTVSLSSTPsLAGTD 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1231 QANVTVAPERLVPIIEGGSYRVWSDTRDLVLDGSESYDPNLEDGDQTPLSFHWACVAST------QREAGGCA-----LN 1299
Cdd:pfam02010   74 IITVTVQPSPLVAVIDGGSSRVVGYNQDLTLDGSESYDPDVDPGSSSGLTYLWSCRRSSsgdnplLNNDPVCFsdqneGT 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1300 FGPRGSSTVTIPRERLAAGVEYTFSLTVWKAGRKEEATNQTVLIRSGRVPIVSLECVSCKAQAVYEVSRssYVYLEGRCL 1379
Cdd:pfam02010  154 LLQSTSSSLTIPASTLQANVTYTFKLTVSKGSRNSASTTQTILVVDGNPPIIILSCISNCNRKNNPVDR--LVLLASTCL 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1380 NCSSGSKRG--RWAARTFSNKTLVLD--ETTTSTGSAGMRLVLRRGVLRDGEGYTFTLTVLGRSGEEEGCASIRLSPNRP 1455
Cdd:pfam02010  232 NCSSDLSDVtyRWLSLGSENTSLVLDqlNSQTSTGRSGPYLVIKAGVLQSGVSYRFTLIVTVYPGLVSGLASISFITNAP 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1456 PLGGSCRLFPLGAvHALTTKVHFECTGWHDAEDagaPLVYALLLRRCRQGHCEEFCVYKGSLS-SYGAVLPPGFRPH-FE 1533
Cdd:pfam02010  312 PTGGTCSVTPTEG-TALETKFTVTCQGWTDDDL---PLTYQFGDISFREASEEWFLLYEGSSQiSISTFLPPGLPANdYQ 387

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530408236  1534 VGLAVVVQDQLGAAvVALNRSLAITLPEPNGSatglTVWLHGLTASVLPGLLRQADPQHVIEYSLA 1599
Cdd:pfam02010  388 VTVVVVVYDSLGAA-TSVSLTITVTPPSSSDE----LLYFLLGTTSDLSALLQSGDPQQAAQLILA 448
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 2103-2222 3.38e-57

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 194.42  E-value: 3.38e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236 2103 FKYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGD--RAFHRNSLDIFRIATPHSLGSVWKIRVWHDNKGLSPAW 2180
Cdd:cd01752     1 YLYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPekPIFERGSVDSFLLTTPFPLGELQSIRLWHDNSGLSPSW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 530408236 2181 FLQHVIVRDLQTARSAFFLVNDWLSVETEanGGLVEKEVLAA 2222
Cdd:cd01752    81 YLSRVIVRDLQTGKKWFFLCNDWLSVEEG--DGTVERTFPVA 120
Polycystin_dom pfam20519
Polycystin domain; This domain represents the polycystin domain from group II of Transient ...
 2698-2876 1.16e-55

Polycystin domain; This domain represents the polycystin domain from group II of Transient receptor potential (TRP) channels (TRPP) including PKD1, PKD2, PKD2L and mucolipins. The polycystin domain display a sandwich-like shape with five beta-sheets in the tilted middle layer, three alpha-helices on one side and a large loop with two short antiparallel beta-sheets on the other.


Pssm-ID: 466668  Cd Length: 199  Bit Score: 193.02  E-value: 1.16e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  2698 AFLAITRSEELWPWMAHVLLPYVHGNQS------------SPELGPPRLRQVRLQEA--LYPDPPGPRVHTCSAAGGFST 2763
Cdd:pfam20519    1 GLLTVTDLDDIWDWLSSVLLPALHSNKTpsglpgsfiayeSLLLGVPRLRQLRVRNSscLVHDKFVREINECHAGYSPPS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  2764 SDY----DVGWESPHNGSGTW-AYSAPDLL-GAWSWGSCAVYDSGGYVQELGLSLEESRDRLRFLQLHNWLDNRSRAVFL 2837
Cdd:pfam20519   81 EDRklysALPYKPVHYGSKYWfIYTPPGLLmGYDHWGHLASYPSGGYVVLLPSSREESLKRLAYLQDNNWLDRGTRAVFV 160

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 530408236  2838 ELTRYSPAVGLHAAVTLRLEFPAAGRALAALSVRPFALR 2876
Cdd:pfam20519  161 DFTLYNADINLFCVVTLRVEFPPTGGVLPSPSVQSVKLL 199
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
 2877-3098 3.15e-43

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 158.59  E-value: 3.15e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  2877 RLSAGLSLPLLT-SVCLLLFAVHFAVAEARTWHREGR------WRVLRLgawarwLLVALTAATALVRLAQLGAADRQWT 2949
Cdd:pfam08016    1 RYVTNRSLFILLcEIVFVVFFLYFVVEEILKIRKHRPsylrsvWNLLDL------AIVILSVVLIVLNIYRDFLADRLIK 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  2950 rFVRGRPRRFTSFDQVAQLSSAARGLAASLLFLLLVKAAQQLRFVRQWSVFGKTLCRALPELLGVTLGLVVLGVAYAQLA 3029
Cdd:pfam08016   75 -SVEASPVTFIDFDRVAQLDNLYRIILAFLVFLTWLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFG 153

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530408236  3030 ILLVSSCVDSLWSVAQALLVLCPgtglsTLCPAESWH--------LSPLLCVGLWALRLWGALRLGAVILRWRYHAL 3098
Cdd:pfam08016  154 YLLFGTQAPNFSNFVKSILTLFR-----TILGDFGYNeifsgnrvLGPLLFLTFVFLVIFILLNLFLAIINDSYVEV 225
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 2105-2208 2.16e-23

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 97.50  E-value: 2.16e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  2105 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDR-AFHRNSLDIFRIATPHSLGSVWKIRVWHDNKGLSPAWFLQ 2183
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNpDFERGAEDSFEIDTDWDVGAILKINLHWDNNGLSDEWFLK 80

                           90       100
                   ....*....|....*....|....*.
gi 530408236  2184 HVIV-RDLQTARSAFFLVNDWLSVET 2208
Cdd:pfam01477   81 SITVeVPGETGGKYTFPCNSWVYGSK 106
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
2103-2205 1.49e-19

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 86.16  E-value: 1.49e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   2103 FKYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLD--GDRAFHRNSLDIFRIATPHSLGSVWKIRVWHDNKglSPAW 2180
Cdd:smart00308    1 GKYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDylFKGIFARGSTYEFTFDVDEDFGELGAVKIKNEHR--HPEW 78

                            90       100
                    ....*....|....*....|....*
gi 530408236   2181 FLQHVIVRDLQTARSAFFLVNDWLS 2205
Cdd:smart00308   79 FLKSITVKDLPTGGKYHFPCNSWVY 103
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 113-194 1.04e-16

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 77.11  E-value: 1.04e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236    113 SVAVGVSDGVLVAGRPVTFYPHPLPSPGGVLYTWDFGDGSpvlTQSQPAANHTYASRGTYHVRLEVNNTVSGAAAQADVR 192
Cdd:smart00089    1 VADVSASPTVGVAGESVTFTATSSDDGSIVSYTWDFGDGT---SSTGPTVTHTYTKPGTYTVTLTVTNAVGSASATVTVV 77


                    ..
gi 530408236    193 VF 194
Cdd:smart00089   78 VQ 79
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 114-188 4.58e-14

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 69.83  E-value: 4.58e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530408236  114 VAVGVSDGVLV-AGRPVTFYPHPLPSPGGVLYTWDFGDGSpVLTQSQPAANHTYASRGTYHVRLEVNNTVSGAAAQ 188
Cdd:cd00146     1 PTASVSAPPVAeLGASVTFSASDSSGGSIVSYKWDFGDGE-VSSSGEPTVTHTYTKPGTYTVTLTVTNAVGSSSTK 75
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
454-760 2.12e-12

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 71.24  E-value: 2.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  454 TSIKVNGSLGLELQqpylFSAVGRGRPASYLWDLGDGGWLEGPEVTHAYNSTGDFTVRVAGWNEV-SRSEAWLNVTVKRR 532
Cdd:COG3291     2 TATPTSGCAPLTVQ----FTDTSSGNATSYEWDFGDGTTSTEANPSHTYTTPGTYTVTLTVTDAAgCSDTTTKTITVGAP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  533 VRGLVVNASRTVVPLNGSVSFSTSLEAGSDVrYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIVTAENEVGSAQDSIFVY 612
Cdd:COG3291    78 NPGVTTVTTSTTVTTLANTANGGATTVVAGS-TVGTGVATSTTTAAAPGGGGGTGTTTTTGTDTGLTGSTGTASDTATVT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  613 VLQLIEGLQVVGGGRYFPTNHTVQLQAVVRDGTNVSYSWTAWRDRGPALAGSGKGFSLTVLEAGTYHVQLRATNMLGSAW 692
Cdd:COG3291   157 TSVSTTDVTSDGTTSASTNPSVTTDTVTTLTGSYTGTIVGGSGSGTVTSGTAGVTTGATSGTSGTGSATSGVAVTDVTLT 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530408236  693 ADCTMDFVEPVGWLMVAASPNPAAVNTSVTLSAELAGGSGVVYTWSLEEGLSWETSEPFTTHSFPTPG 760
Cdd:COG3291   237 GISTGDAGTPGTNTVTTSGANTAGTSTITGGTSGVVTTSAATGTSTNGTGGLGTTTAITPGNVSTTAD 304
GPS smart00303
G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin ...
 1996-2045 1.92e-10

G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin REJ and polycystin.


Pssm-ID: 197639  Cd Length: 49  Bit Score: 58.55  E-value: 1.92e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 530408236   1996 YTSLCQYFSEEDMVWRTEGLLPLEETSpRQAVCLTRHLTAFGASLFVPPS 2045
Cdd:smart00303    1 FNPICVFWDESSGEWSTRGCELLETNG-THTTCSCNHLTTFAVLMDVPPI 49
 
Name Accession Description Interval E-value
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 1-1713 0e+00

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 3222.97  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236     1 MNRMQGLQVSTVPAVLSPNATLALTAGVLVDSAVEVAFLWTFGDGEQALHQFQPPYNESFPVPDPSVAQVLVEHNVMHTY 80
Cdd:TIGR00864  977 LNPMQGLQVKGVPAVLPPGATLALTAGVLIDMAVEAAFLWSFGDGEQALFEFKPPYNESFPCPDPSPAQVLLEHNVMHIY 1056

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236    81 AAPGEYLLTVLASNAFENLTQQVPVSVRASLPSVAVGVSDGVLVAGRPVTFYPHPLPSPGGVLYTWDFGDGSPVLTQSQP 160
Cdd:TIGR00864 1057 AAPGEYLATVLASNAFENISQQINMSVRAILPRVAIGTEDGLLLAGKPADFEAHPLPSPGGIHYEWDFGDGSALLQGRQP 1136

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   161 AANHTYASRGTYHVRLEVNNTVSGAAAQADVRVFEELRGLSVDMSLAVEQGAPVVVSAAVQTGDNITWTFDMGDGTVLSG 240
Cdd:TIGR00864 1137 AAAHTFAKRGPFHVCLEVNNTISGAAACADMFAFEEIEGLSADMSLATELGAATTVRAALQSGDNITWTFDMGDGKSLSG 1216

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   241 PEATVEHVYLRAQNCTVTVGAASPAGHLARSLHVLVFVLEVLRVEPAACIPTQPDARLTAYVTGNPAHYLFDWTFGDGSS 320
Cdd:TIGR00864 1217 PEATVEHKYAKAGNCTVNIGAANAAGHGARIIHVEVFVFEVAGIEPAACIGEHADANFRARVSGNAAHYLFDWSFGDGSP 1296

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   321 NTTVRGCPTVTHNFTRSGTFPLALVLSSRVNRAHYFTSICVEPEVGNVTLQPERQFVQLGDEAWLVACAWPPFPYRYTWD 400
Cdd:TIGR00864 1297 NETHHGCPGISHNFRGNGTFPLALTISSGVNKAHFFTQICVEPELGKISLQAEKQFFALGDEAQFQACAEPEFNYRYEWD 1376

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   401 FGTEEAAPTRARGPEVTFIYRDPGSYLVTVTASNNISAANDSALVEVQEPVLVTSIKVNGSLG--LELQQPYLFSAVGRG 478
Cdd:TIGR00864 1377 FGGEEAAPLPAAGAEVTFIYNDPGCYLVTVAASNNISAANDSALIEVLEPVGATSFKHNGSHGnnLELGQPYLFSAFGRA 1456

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   479 RPASYLWDLGDGGWLEGPEVTHAYNSTGDFTVRVAGWNEVSRSEAWLNVTVKRRVRGLVVNASRTVVPLNGSVSFSTSLE 558
Cdd:TIGR00864 1457 RNASYLWDFGDGGLLEGPEILHAFNSPGDFNIRLAAANEVGKNEATLNVAVKARVRGLTINASLTNVPLNGSVHFEAHLD 1536

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   559 AGSDVRYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIVTAENEVGSAQDSIFVYVLQLIEGLQVVGG------------- 625
Cdd:TIGR00864 1537 AGDDVRFSWILCDHCTPIFGGNTIFYTFRSVGTFNIIVTAENDVGAAQASIFLFVLQEIEGLQILGEtaegggggvqeld 1616

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   626 GRYFPTNHTVQLQAVVRDGTNVSYSWTAWRD---RGPALAGSGKGFSLTVLEAGTYHVQLRATNMLGSAWADCTMDFVEP 702
Cdd:TIGR00864 1617 GCYFETNHTVQFHAGFKDGTNLSFSWNAILDnepDGPAFAGSGKGAKLNPLEAGPCDIFLQAANLLGQATADCTIDFLEP 1696

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   703 VGWLMVAASPNPAAVNTSVTLSAELAGGSGVVYTWSLEEGLSWETSEPFTTHSFPTPGLHLVTMTAGNPLGSANATVEVD 782
Cdd:TIGR00864 1697 AGNLMLAASDNPAAVNALINLSAELAEGSGLQYRWFLEEGDDLETSEPFMSHSFPSAGLHLVTMKAFNELGSANASEEVD 1776

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   783 VQVPVSGLSIRASEPGGS-FVAAGSSVPFWGQLATGTNVSWCWAVPGGSSKRGPHVTMVFPDAGTFSIRLNASNAVSWVS 861
Cdd:TIGR00864 1777 VQEPISGLKIRAADAGEQnFFAADSSVCFQGELATGTNVSWCWAIDGGSSKMGKHACMTFPDAGTFAIRLNASNAVSGKS 1856

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   862 ATYNLTAEEPIVGLVLWASSKVVAPGQLVHFQILLAAGSAVTFRLQVGGANPEVL-PGPRFSHSFPRVGDHVVSVRGKNH 940
Cdd:TIGR00864 1857 ASREFFAEEPIFGLELKASKKIAAIGEKVEFQILLAAGSAVNFRLQIGGAAPEVLqPGPRFSHSFPRVDDHMVNLRAKNE 1936

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   941 VSWAQAQVRIVVLEAVSGLQVPNCCEPGIATGTERNFTARVQRGSRVAYAWYFSLQKVQGDSLVILSGRDVTYTPVAAGL 1020
Cdd:TIGR00864 1937 VSCAQANLHIEVLEAVRGLQIPDCCAAGIATGEEKNFTANVQRGKPVAFAWTFDLHHLHGDSLVIHMGKDVSYTAEAAGL 2016

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1021 LEIQVRAFNALGSENRTLVLEVQDAVQYVALQSGP--CFTNRSAQFEAATSPSPRRVAYHWDFGDGSPGQDTDEPRAEHS 1098
Cdd:TIGR00864 2017 LEIQLGAFNALGAENITLQLEAQDALMDAALQAGPqdCFTNKMAQFEAATSPKPNFMACHWDFGDGSAGQDTDEPRAEHE 2096

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1099 YLRPGDYRVQVNASNLVSFFVAQATVTVQVLACREPEVDVVLPLQVLMRRSQRNYLEAHVDLRDCVTYQTEYRWEVYRTA 1178
Cdd:TIGR00864 2097 YLHPGDYRVQVNASNLVSFFSAHAEINVQVLACEEPEVDVVLALQLAIRRSQPNLLEAHVDLKDCLRYGAEYLWEILRAA 2176

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1179 SCQRPGRPARVALPG-------------VDVSRPRLVLPRLALPVGHYCFVFVVSFGDTPLTQSIQANVTVAPERLVPII 1245
Cdd:TIGR00864 2177 SCDNDGHFARGALNGatrsfpviplpaeVDVQRLQLSLPKLALAAGHYCFVFSLSFEDTPLKKAACANLGVAAARLMPII 2256

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1246 EGGSYRVWSDTRDLVLDGSESYDPNLEDGDQTPLSFHWACVASTQREAGGCALNFGPRG-SSTVTIPRERLAAGVEYTFS 1324
Cdd:TIGR00864 2257 EGGSYRVWSDTQDLQLDAEESYDPNLDDDDQSLLHFHWACQASSKGEAGCCALNFGLGGkGPTLGIPGEELAAGIEYTFK 2336

                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1325 LTVWKAGRKEEATNQTVLIRSGRVPIVSLECVSCKAQAVYEVSRSSYVYLEGRCLNCSSGSKRGRWAARTFSNKTLVLDE 1404
Cdd:TIGR00864 2337 LSIGKAGMKEEATNQTVLIQSGHIPIVSLECVSCKAQALYEVSQNSYVYLEGRCLNCQSGFHRGRWAARTFQNDTLVLDE 2416

                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1405 TTTSTGSAGMRLVLRRGVLRDGEGYTFTLTVLGRSGEEEGCASIRLSPNRPPLGGSCRLFPLG--------------AVH 1470
Cdd:TIGR00864 2417 SSTSTGSAGMNLVLRQGVLHDGEGYNFTLHVLDDSGDEEGAASIRLHHNMPPDGGECHLFPGGetgqehgdkedevwAIE 2496

                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1471 ALTTKVHFECTGWHDAEDAGAPLVYALLLRRCRQGHCEEFCVYKGSLSSYGAVLPPGFR-PHFEVGLAVVVQDQLGAAVV 1549
Cdd:TIGR00864 2497 ALLDKVHFECSGWHDAEDAEAPLLYALLLNRCRDDHCEEFCVYKGSLPEHGAFLPPGFRsAHFEVGLAITVEDHLGAAIR 2576

                         1610      1620      1630      1640      1650      1660      1670      1680
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1550 ALNRSLAITLPEPNGSATGLTVWLHGLTASVLPGLLRQADPQHVIEYSLALVTVLNEYERALDVAAEPKHERQHRAQIRK 1629
Cdd:TIGR00864 2577 ALNKSIAITLPDPNGEASGLPHWLHDLIASKLKGLLDQADFQHVIELSLALITVLNEYEQALDSAAEPKHERGHRAQIRK 2656

                         1690      1700      1710      1720      1730      1740      1750      1760
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1630 NITETLVSLRVHTVDDIQQIAAALAQCMGPSRELVCRSCLKQTLHKLEAMMLILQAETTAGTVTPTAIGDSILNITGDLI 1709
Cdd:TIGR00864 2657 NITEALTALDLHTVDDIQQIAAALAQCMAPSREFICEECLKQTLHKLEAMLEILQADTKAGIVTPTAIADNILNIMGDLI 2736


                   ....
gi 530408236  1710 HLAS 1713
Cdd:TIGR00864 2737 HLAS 2740
REJ pfam02010
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ...
 1156-1599 2.10e-132

REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.


Pssm-ID: 366875 [Multi-domain]  Cd Length: 448  Bit Score: 423.84  E-value: 2.10e-132
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1156 AHVDLRDCV-TYQTEYRWEVYRTASC---QRPGRPARVALPGVDvsrprlvLPRLALPVGHYCFVFVVSFGDTP-LTQSI 1230
Cdd:pfam02010    1 ASVELNGCFsAYTIDYLWSVFTVSSNlnlQTISSPKDLVLPQLT-------IPSGTLPYGTYVFTLTVSLSSTPsLAGTD 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1231 QANVTVAPERLVPIIEGGSYRVWSDTRDLVLDGSESYDPNLEDGDQTPLSFHWACVAST------QREAGGCA-----LN 1299
Cdd:pfam02010   74 IITVTVQPSPLVAVIDGGSSRVVGYNQDLTLDGSESYDPDVDPGSSSGLTYLWSCRRSSsgdnplLNNDPVCFsdqneGT 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1300 FGPRGSSTVTIPRERLAAGVEYTFSLTVWKAGRKEEATNQTVLIRSGRVPIVSLECVSCKAQAVYEVSRssYVYLEGRCL 1379
Cdd:pfam02010  154 LLQSTSSSLTIPASTLQANVTYTFKLTVSKGSRNSASTTQTILVVDGNPPIIILSCISNCNRKNNPVDR--LVLLASTCL 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1380 NCSSGSKRG--RWAARTFSNKTLVLD--ETTTSTGSAGMRLVLRRGVLRDGEGYTFTLTVLGRSGEEEGCASIRLSPNRP 1455
Cdd:pfam02010  232 NCSSDLSDVtyRWLSLGSENTSLVLDqlNSQTSTGRSGPYLVIKAGVLQSGVSYRFTLIVTVYPGLVSGLASISFITNAP 311

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1456 PLGGSCRLFPLGAvHALTTKVHFECTGWHDAEDagaPLVYALLLRRCRQGHCEEFCVYKGSLS-SYGAVLPPGFRPH-FE 1533
Cdd:pfam02010  312 PTGGTCSVTPTEG-TALETKFTVTCQGWTDDDL---PLTYQFGDISFREASEEWFLLYEGSSQiSISTFLPPGLPANdYQ 387

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530408236  1534 VGLAVVVQDQLGAAvVALNRSLAITLPEPNGSatglTVWLHGLTASVLPGLLRQADPQHVIEYSLA 1599
Cdd:pfam02010  388 VTVVVVVYDSLGAA-TSVSLTITVTPPSSSDE----LLYFLLGTTSDLSALLQSGDPQQAAQLILA 448
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 170-1140 4.54e-61

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 234.59  E-value: 4.54e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   170 GTYHVRLEVNNTVSGAAAQADVRVFEELRGLSVDMSLA--VEQGAPVVVSAAVQTGDNITWTFDMGDGTVLSGPEATVEH 247
Cdd:TIGR00864  866 GPVQVDLMAENNASEANLSLLVQAEEPICGLRAQPHPAarVLMESLVRYSASVEAGSDMTFKWTIDDKPFFTFQNTVFNV 945

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   248 VYLRAQNCTVTVGAASPAGHLARSLHVLVFVLE-----VLRVEPAACIPTQPDARLTAYVTGNPAHYLFDWTFGDG---- 318
Cdd:TIGR00864  946 IYQHAAVFKLSLTAMNHVSNLTEDFNVTVDRLNpmqglQVKGVPAVLPPGATLALTAGVLIDMAVEAAFLWSFGDGeqal 1025

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   319 --------SSNTTVRGCP-------TVTHNFTRSGTFPLALVLSSRVNRAHYFTSICVEPEVGNVTLQPERQFVQLGDEA 383
Cdd:TIGR00864 1026 fefkppynESFPCPDPSPaqvllehNVMHIYAAPGEYLATVLASNAFENISQQINMSVRAILPRVAIGTEDGLLLAGKPA 1105

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   384 WLVACAWP-PFPYRYTWDFGTEEAAPTRARgPEVTFIYRDPGSYLVTVTASNNISAANDSALVEVQEPvlVTSIKVNGSL 462
Cdd:TIGR00864 1106 DFEAHPLPsPGGIHYEWDFGDGSALLQGRQ-PAAAHTFAKRGPFHVCLEVNNTISGAAACADMFAFEE--IEGLSADMSL 1182

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   463 GLELQQPYLFSA-VGRGRPASYLWDLGDGGWLEGPE--VTHAYNSTGDFTVRVAGWNEVsrSEAWLNVTVKRRVRGLVVN 539
Cdd:TIGR00864 1183 ATELGAATTVRAaLQSGDNITWTFDMGDGKSLSGPEatVEHKYAKAGNCTVNIGAANAA--GHGARIIHVEVFVFEVAGI 1260

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   540 ASRTVVPLNGSVSFSTSLEAG-SDVRYSWVLCDRC--TPIPGGPTISYTFRSVGTFNIIVTAENEVGSAQDSIFVYVLQL 616
Cdd:TIGR00864 1261 EPAACIGEHADANFRARVSGNaAHYLFDWSFGDGSpnETHHGCPGISHNFRGNGTFPLALTISSGVNKAHFFTQICVEPE 1340

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   617 IEGLQVVGGGRYFPTNHTVQLQAVVRDGTNVSYSWTAWRDRGPALAGSGKGFSLTVLEAGTYHVQLRATNMLGSAWADCT 696
Cdd:TIGR00864 1341 LGKISLQAEKQFFALGDEAQFQACAEPEFNYRYEWDFGGEEAAPLPAAGAEVTFIYNDPGCYLVTVAASNNISAANDSAL 1420

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   697 MDFVEPVGWLMVAASP---NPAAVNTSVTLSAeLAGGSGVVYTWSLEEGLSWETSEpfTTHSFPTPGLHLVTMTAGNPLG 773
Cdd:TIGR00864 1421 IEVLEPVGATSFKHNGshgNNLELGQPYLFSA-FGRARNASYLWDFGDGGLLEGPE--ILHAFNSPGDFNIRLAAANEVG 1497

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   774 SANATVEVDVQVPVSGLSIRASEpggSFVAAGSSVPFWGQLATGTNVSWCWAVPGGSSK--RGPHVTMVFPDAGTFSIRL 851
Cdd:TIGR00864 1498 KNEATLNVAVKARVRGLTINASL---TNVPLNGSVHFEAHLDAGDDVRFSWILCDHCTPifGGNTIFYTFRSVGTFNIIV 1574

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   852 NASNAVSWVSATYNLTAEEPIVGLVLWASSKVVAPG-------------QLVHFQILLAAGSAVTFR----LQVGGANPE 914
Cdd:TIGR00864 1575 TAENDVGAAQASIFLFVLQEIEGLQILGETAEGGGGgvqeldgcyfetnHTVQFHAGFKDGTNLSFSwnaiLDNEPDGPA 1654

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   915 V-LPGPRFSHSFPRVGDHVVSVRGKNHVSWAQAQVRIVVLEAVSGLQVPNCCEPgIATGTERNFTARVQRGSRVAYAWYF 993
Cdd:TIGR00864 1655 FaGSGKGAKLNPLEAGPCDIFLQAANLLGQATADCTIDFLEPAGNLMLAASDNP-AAVNALINLSAELAEGSGLQYRWFL 1733

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   994 SlqkvQGDSLViLSGRDVTYTPVAAGLLEIQVRAFNALGSENRTLVLEVQDAV-------------QYVALQSGPCFtnr 1060
Cdd:TIGR00864 1734 E----EGDDLE-TSEPFMSHSFPSAGLHLVTMKAFNELGSANASEEVDVQEPIsglkiraadageqNFFAADSSVCF--- 1805

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  1061 saQFEAATSPSprrVAYHWDFGDGSPGQdtdEPRAEHSYLRPGDYRVQVNASNLVSFFVAQATVTVQvlacrEPEVDVVL 1140
Cdd:TIGR00864 1806 --QGELATGTN---VSWCWAIDGGSSKM---GKHACMTFPDAGTFAIRLNASNAVSGKSASREFFAE-----EPIFGLEL 1872
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 2103-2222 3.38e-57

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 194.42  E-value: 3.38e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236 2103 FKYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGD--RAFHRNSLDIFRIATPHSLGSVWKIRVWHDNKGLSPAW 2180
Cdd:cd01752     1 YLYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPekPIFERGSVDSFLLTTPFPLGELQSIRLWHDNSGLSPSW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 530408236 2181 FLQHVIVRDLQTARSAFFLVNDWLSVETEanGGLVEKEVLAA 2222
Cdd:cd01752    81 YLSRVIVRDLQTGKKWFFLCNDWLSVEEG--DGTVERTFPVA 120
Polycystin_dom pfam20519
Polycystin domain; This domain represents the polycystin domain from group II of Transient ...
 2698-2876 1.16e-55

Polycystin domain; This domain represents the polycystin domain from group II of Transient receptor potential (TRP) channels (TRPP) including PKD1, PKD2, PKD2L and mucolipins. The polycystin domain display a sandwich-like shape with five beta-sheets in the tilted middle layer, three alpha-helices on one side and a large loop with two short antiparallel beta-sheets on the other.


Pssm-ID: 466668  Cd Length: 199  Bit Score: 193.02  E-value: 1.16e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  2698 AFLAITRSEELWPWMAHVLLPYVHGNQS------------SPELGPPRLRQVRLQEA--LYPDPPGPRVHTCSAAGGFST 2763
Cdd:pfam20519    1 GLLTVTDLDDIWDWLSSVLLPALHSNKTpsglpgsfiayeSLLLGVPRLRQLRVRNSscLVHDKFVREINECHAGYSPPS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  2764 SDY----DVGWESPHNGSGTW-AYSAPDLL-GAWSWGSCAVYDSGGYVQELGLSLEESRDRLRFLQLHNWLDNRSRAVFL 2837
Cdd:pfam20519   81 EDRklysALPYKPVHYGSKYWfIYTPPGLLmGYDHWGHLASYPSGGYVVLLPSSREESLKRLAYLQDNNWLDRGTRAVFV 160

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 530408236  2838 ELTRYSPAVGLHAAVTLRLEFPAAGRALAALSVRPFALR 2876
Cdd:pfam20519  161 DFTLYNADINLFCVVTLRVEFPPTGGVLPSPSVQSVKLL 199
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
 2877-3098 3.15e-43

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 158.59  E-value: 3.15e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  2877 RLSAGLSLPLLT-SVCLLLFAVHFAVAEARTWHREGR------WRVLRLgawarwLLVALTAATALVRLAQLGAADRQWT 2949
Cdd:pfam08016    1 RYVTNRSLFILLcEIVFVVFFLYFVVEEILKIRKHRPsylrsvWNLLDL------AIVILSVVLIVLNIYRDFLADRLIK 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  2950 rFVRGRPRRFTSFDQVAQLSSAARGLAASLLFLLLVKAAQQLRFVRQWSVFGKTLCRALPELLGVTLGLVVLGVAYAQLA 3029
Cdd:pfam08016   75 -SVEASPVTFIDFDRVAQLDNLYRIILAFLVFLTWLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFG 153

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530408236  3030 ILLVSSCVDSLWSVAQALLVLCPgtglsTLCPAESWH--------LSPLLCVGLWALRLWGALRLGAVILRWRYHAL 3098
Cdd:pfam08016  154 YLLFGTQAPNFSNFVKSILTLFR-----TILGDFGYNeifsgnrvLGPLLFLTFVFLVIFILLNLFLAIINDSYVEV 225
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 409-1130 3.54e-35

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 149.08  E-value: 3.54e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   409 TRARGPEVTFIYRDPGSYLVTVTASNNISAANDSALVEVQEPVLVTSI------------KVNGS-LGLELQQPYLFSAV 475
Cdd:TIGR00864  729 TRLLGAELNAGLPLPGLYELLAESAKGSDLHNASCSFDVLPPLAGLRVihpapqdgrlflESNGSaLLLQVDSGANAEAK 808

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   476 GRGR------------PASYLWDLGDGGWLEG--PEVTHAY-------------NSTGDFTVRVAGWNEVSRSEAWLNVT 528
Cdd:TIGR00864  809 AFWPggnssarfenvcPAEFASRLCHPSTFEGgcAEEAEDSlfavlalnwlkegEHTGPVQVDLMAENNASEANLSLLVQ 888

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   529 VKRRVRGLVVNASRTVVPLNGS-VSFSTSLEAGSDVRYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIVTAENEVGSAQD 607
Cdd:TIGR00864  889 AEEPICGLRAQPHPAARVLMESlVRYSASVEAGSDMTFKWTIDDKPFFTFQNTVFNVIYQHAAVFKLSLTAMNHVSNLTE 968

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   608 SIFVYV--LQLIEGLQVVGGGRYFPTNHTVQLQA--VVRDGTNVSYSWTaWRDRGPALAGSGKGF--SLTVLEAGTYHVQ 681
Cdd:TIGR00864  969 DFNVTVdrLNPMQGLQVKGVPAVLPPGATLALTAgvLIDMAVEAAFLWS-FGDGEQALFEFKPPYneSFPCPDPSPAQVL 1047

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   682 LR--------------ATNMLGSAWADCT----MDFVEPVGWLMVAASPNPAAVNTSVTLSAE-LAGGSGVVYTWSLEEG 742
Cdd:TIGR00864 1048 LEhnvmhiyaapgeylATVLASNAFENISqqinMSVRAILPRVAIGTEDGLLLAGKPADFEAHpLPSPGGIHYEWDFGDG 1127

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   743 LSWET-SEPFTTHSFPTPGLHLVTMTAGNPLGSANATVEVDVQVPVSGLSIRASEPggsfVAAGSSVPFWGQLATGTNVS 821
Cdd:TIGR00864 1128 SALLQgRQPAAAHTFAKRGPFHVCLEVNNTISGAAACADMFAFEEIEGLSADMSLA----TELGAATTVRAALQSGDNIT 1203

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   822 WCWAVPGGSSKRGPHVTM--VFPDAGTFSIRLNASNAVSwvSATYNLTAEEPIVGLVLWASSKVVAPGQLVHFQILLAAG 899
Cdd:TIGR00864 1204 WTFDMGDGKSLSGPEATVehKYAKAGNCTVNIGAANAAG--HGARIIHVEVFVFEVAGIEPAACIGEHADANFRARVSGN 1281

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   900 SA---VTFRLQVGGANPEVLPGPRFSHSFPRVGDHVVSVRGKNHVSWAQAQVRIVVLEAVSGLQVpNCCEPGIATGTERN 976
Cdd:TIGR00864 1282 AAhylFDWSFGDGSPNETHHGCPGISHNFRGNGTFPLALTISSGVNKAHFFTQICVEPELGKISL-QAEKQFFALGDEAQ 1360

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   977 FTARVQRGSRVAYAWYFSLQKvqgDSLVILSGRDVTYTPVAAGLLEIQVRAFNALGSENRTLVLEVQDAVQYVALQ-SGP 1055
Cdd:TIGR00864 1361 FQACAEPEFNYRYEWDFGGEE---AAPLPAAGAEVTFIYNDPGCYLVTVAASNNISAANDSALIEVLEPVGATSFKhNGS 1437

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530408236  1056 CFTNRSAQ----FEAATSPSPrrVAYHWDFGDGSPgqdTDEPRAEHSYLRPGDYRVQVNASNLVSffVAQATVTVQVLA 1130
Cdd:TIGR00864 1438 HGNNLELGqpylFSAFGRARN--ASYLWDFGDGGL---LEGPEILHAFNSPGDFNIRLAAANEVG--KNEATLNVAVKA 1509
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 2103-2222 4.76e-28

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 111.11  E-value: 4.76e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236 2103 FKYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLD---GDRAFHRNSLDIFRIATPhSLGSVWKIRVWHDNKGLSPA 2179
Cdd:cd01756     1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKksnNKNKFERGQTDKFTVEAV-DLGKLKKIRIGHDNSGLGAG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 530408236 2180 WFLQHVIVRDLQTARSAFFLVNDWLSveTEANGGLVEKEVLAA 2222
Cdd:cd01756    80 WFLDKVEIREPGTGDEYTFPCNRWLD--KDEDDGQIVRELYPS 120
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 2105-2208 2.16e-23

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 97.50  E-value: 2.16e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  2105 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDR-AFHRNSLDIFRIATPHSLGSVWKIRVWHDNKGLSPAWFLQ 2183
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNpDFERGAEDSFEIDTDWDVGAILKINLHWDNNGLSDEWFLK 80

                           90       100
                   ....*....|....*....|....*.
gi 530408236  2184 HVIV-RDLQTARSAFFLVNDWLSVET 2208
Cdd:pfam01477   81 SITVeVPGETGGKYTFPCNSWVYGSK 106
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
2103-2205 1.49e-19

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 86.16  E-value: 1.49e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   2103 FKYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLD--GDRAFHRNSLDIFRIATPHSLGSVWKIRVWHDNKglSPAW 2180
Cdd:smart00308    1 GKYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDylFKGIFARGSTYEFTFDVDEDFGELGAVKIKNEHR--HPEW 78

                            90       100
                    ....*....|....*....|....*
gi 530408236   2181 FLQHVIVRDLQTARSAFFLVNDWLS 2205
Cdd:smart00308   79 FLKSITVKDLPTGGKYHFPCNSWVY 103
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 708-777 1.24e-17

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 79.35  E-value: 1.24e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   708 VAASPNPAAVNTSVTLSAELAGGSGVVYTWSLEEGLSWETSEPFTTHSFPTPGLHLVTMTAGNPLGSANA 777
Cdd:pfam00801    1 VSASGTVVAAGQPVTFTATLADGSNVTYTWDFGDSPGTSGSGPTVTHTYLSPGTYTVTLTASNAVGSANA 70
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 113-194 1.04e-16

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 77.11  E-value: 1.04e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236    113 SVAVGVSDGVLVAGRPVTFYPHPLPSPGGVLYTWDFGDGSpvlTQSQPAANHTYASRGTYHVRLEVNNTVSGAAAQADVR 192
Cdd:smart00089    1 VADVSASPTVGVAGESVTFTATSSDDGSIVSYTWDFGDGT---SSTGPTVTHTYTKPGTYTVTLTVTNAVGSASATVTVV 77


                    ..
gi 530408236    193 VF 194
Cdd:smart00089   78 VQ 79
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 877-946 1.38e-16

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 76.66  E-value: 1.38e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   877 LWASSKVVAPGQLVHFQILLAAGSAVTFRLQVGGANPEVLPGPRFSHSFPRVGDHVVSVRGKNHVSWAQA 946
Cdd:pfam00801    1 VSASGTVVAAGQPVTFTATLADGSNVTYTWDFGDSPGTSGSGPTVTHTYLSPGTYTVTLTASNAVGSANA 70
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 2104-2205 1.69e-16

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 77.76  E-value: 1.69e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236 2104 KYEILVKTGWGRGSGTTAHVGIMLYGVD-SRSGHRHLDGDRAFHRNSLDIFRIATPHSLGSVWKIRVWHDNKGLSPAWFL 2182
Cdd:cd00113     2 RYTVTIKTGDKKGAGTDSNISLALYGENgNSSDIPILDGPGSFERGSTDTFQIDLKLDIGDITKVYLRRDGSGLSDGWYC 81

                          90       100
                  ....*....|....*....|...
gi 530408236 2183 QHVIVRDLQTARSAFFLVNDWLS 2205
Cdd:cd00113    82 ESITVQALGTKKVYTFPVNRWVL 104
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 622-693 1.94e-16

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 76.27  E-value: 1.94e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530408236   622 VVGGGRYFPTNHTVQLQAVVRDGTNVSYSWTAWRdrGPALAGSGKGFSLTVLEAGTYHVQLRATNMLGSAWA 693
Cdd:pfam00801    1 VSASGTVVAAGQPVTFTATLADGSNVTYTWDFGD--SPGTSGSGPTVTHTYLSPGTYTVTLTASNAVGSANA 70
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 538-607 2.79e-16

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 75.50  E-value: 2.79e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   538 VNASRTVVPLNGSVSFSTSLEAGSDVRYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIVTAENEVGSAQD 607
Cdd:pfam00801    1 VSASGTVVAAGQPVTFTATLADGSNVTYTWDFGDSPGTSGSGPTVTHTYLSPGTYTVTLTASNAVGSANA 70
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 1053-1120 3.81e-16

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 75.12  E-value: 3.81e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530408236  1053 SGPCFTNRSAQFEAaTSPSPRRVAYHWDFGDgSPGQDTDEPRAEHSYLRPGDYRVQVNASNLVSFFVA 1120
Cdd:pfam00801    5 GTVVAAGQPVTFTA-TLADGSNVTYTWDFGD-SPGTSGSGPTVTHTYLSPGTYTVTLTASNAVGSANA 70
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 116-187 4.49e-16

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 75.12  E-value: 4.49e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530408236   116 VGVSDGVLVAGRPVTFYPHpLPSPGGVLYTWDFGDgSPVLTQSQPAANHTYASRGTYHVRLEVNNTVSGAAA 187
Cdd:pfam00801    1 VSASGTVVAAGQPVTFTAT-LADGSNVTYTWDFGD-SPGTSGSGPTVTHTYLSPGTYTVTLTASNAVGSANA 70
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 370-441 8.98e-16

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 74.35  E-value: 8.98e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530408236   370 LQPERQFVQLGDEAWLVACAWPPFPYRYTWDFGteEAAPTRARGPEVTFIYRDPGSYLVTVTASNNISAAND 441
Cdd:pfam00801    1 VSASGTVVAAGQPVTFTATLADGSNVTYTWDFG--DSPGTSGSGPTVTHTYLSPGTYTVTLTASNAVGSANA 70
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 1045-1127 4.70e-15

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 72.48  E-value: 4.70e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   1045 AVQYVALQSGPcfTNRSAQFEAATSPSPRRVAYHWDFGDGSpgqDTDEPRAEHSYLRPGDYRVQVNASNLVSFFVAQATV 1124
Cdd:smart00089    2 ADVSASPTVGV--AGESVTFTATSSDDGSIVSYTWDFGDGT---SSTGPTVTHTYTKPGTYTVTLTVTNAVGSASATVTV 76


                    ...
gi 530408236   1125 TVQ 1127
Cdd:smart00089   77 VVQ 79
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 205-270 7.03e-15

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 71.65  E-value: 7.03e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530408236   205 SLAVEQGAPVVVSAAVQTGDNITWTFDMGDGTVLSGPEATVEHVYLRAQNCTVTVGAASPAGHLAR 270
Cdd:pfam00801    5 GTVVAAGQPVTFTATLADGSNVTYTWDFGDSPGTSGSGPTVTHTYLSPGTYTVTLTASNAVGSANA 70
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 797-862 8.21e-15

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 71.65  E-value: 8.21e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530408236   797 PGGSFVAAGSSVPFWGQLATGTNVSWCWAVPG--GSSKRGPHVTMVFPDAGTFSIRLNASNAVSWVSA 862
Cdd:pfam00801    3 ASGTVVAAGQPVTFTATLADGSNVTYTWDFGDspGTSGSGPTVTHTYLSPGTYTVTLTASNAVGSANA 70
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 114-188 4.58e-14

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 69.83  E-value: 4.58e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530408236  114 VAVGVSDGVLV-AGRPVTFYPHPLPSPGGVLYTWDFGDGSpVLTQSQPAANHTYASRGTYHVRLEVNNTVSGAAAQ 188
Cdd:cd00146     1 PTASVSAPPVAeLGASVTFSASDSSGGSIVSYKWDFGDGE-VSSSGEPTVTHTYTKPGTYTVTLTVTNAVGSSSTK 75
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 535-613 1.57e-13

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 68.25  E-value: 1.57e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236    535 GLVVNASRTVVPLNGSVSFS-TSLEAGSDVRYSWVLCDRctPIPGGPTISYTFRSVGTFNIIVTAENEVGSAQDSIFVYV 613
Cdd:smart00089    1 VADVSASPTVGVAGESVTFTaTSSDDGSIVSYTWDFGDG--TSSTGPTVTHTYTKPGTYTVTLTVTNAVGSASATVTVVV 78
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 453-530 3.93e-13

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 67.09  E-value: 3.93e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236    453 VTSIKVNGSLGLeLQQPYLFSAV--GRGRPASYLWDLGDGGWLEGPEVTHAYNSTGDFTVRVAGWNEVSRSEAWLNVTVK 530
Cdd:smart00089    1 VADVSASPTVGV-AGESVTFTATssDDGSIVSYTWDFGDGTSSTGPTVTHTYTKPGTYTVTLTVTNAVGSASATVTVVVQ 79
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
454-760 2.12e-12

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 71.24  E-value: 2.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  454 TSIKVNGSLGLELQqpylFSAVGRGRPASYLWDLGDGGWLEGPEVTHAYNSTGDFTVRVAGWNEV-SRSEAWLNVTVKRR 532
Cdd:COG3291     2 TATPTSGCAPLTVQ----FTDTSSGNATSYEWDFGDGTTSTEANPSHTYTTPGTYTVTLTVTDAAgCSDTTTKTITVGAP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  533 VRGLVVNASRTVVPLNGSVSFSTSLEAGSDVrYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIVTAENEVGSAQDSIFVY 612
Cdd:COG3291    78 NPGVTTVTTSTTVTTLANTANGGATTVVAGS-TVGTGVATSTTTAAAPGGGGGTGTTTTTGTDTGLTGSTGTASDTATVT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  613 VLQLIEGLQVVGGGRYFPTNHTVQLQAVVRDGTNVSYSWTAWRDRGPALAGSGKGFSLTVLEAGTYHVQLRATNMLGSAW 692
Cdd:COG3291   157 TSVSTTDVTSDGTTSASTNPSVTTDTVTTLTGSYTGTIVGGSGSGTVTSGTAGVTTGATSGTSGTGSATSGVAVTDVTLT 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530408236  693 ADCTMDFVEPVGWLMVAASPNPAAVNTSVTLSAELAGGSGVVYTWSLEEGLSWETSEPFTTHSFPTPG 760
Cdd:COG3291   237 GISTGDAGTPGTNTVTTSGANTAGTSTITGGTSGVVTTSAATGTSTNGTGGLGTTTAITPGNVSTTAD 304
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 458-523 2.16e-12

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 64.72  E-value: 2.16e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530408236   458 VNGSLGLELQQPYLFSA-VGRGRPASYLWDLGD--GGWLEGPEVTHAYNSTGDFTVRVAGWNEVSRSEA 523
Cdd:pfam00801    2 SASGTVVAAGQPVTFTAtLADGSNVTYTWDFGDspGTSGSGPTVTHTYLSPGTYTVTLTASNAVGSANA 70
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 710-784 3.36e-12

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 64.39  E-value: 3.36e-12
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530408236    710 ASPNPAAVNTSVTLSAELAG-GSGVVYTWSLEEGLSWetSEPFTTHSFPTPGLHLVTMTAGNPLGSANATVEVDVQ 784
Cdd:smart00089    6 ASPTVGVAGESVTFTATSSDdGSIVSYTWDFGDGTSS--TGPTVTHTYTKPGTYTVTLTVTNAVGSASATVTVVVQ 79
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 804-863 5.26e-12

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 64.01  E-value: 5.26e-12
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530408236    804 AGSSVPFWGQLAT-GTNVSWCWAVPGGSSKRGPHVTMVFPDAGTFSIRLNASNAVSWVSAT 863
Cdd:smart00089   13 AGESVTFTATSSDdGSIVSYTWDFGDGTSSTGPTVTHTYTKPGTYTVTLTVTNAVGSASAT 73
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 965-1036 1.78e-11

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 62.02  E-value: 1.78e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530408236   965 CEPGIATGTERNFTARVQRGSRVAYAWYFslqkvqGDSLV-ILSGRDVTYTPVAAGLLEIQVRAFNALGSENR 1036
Cdd:pfam00801    4 SGTVVAAGQPVTFTATLADGSNVTYTWDF------GDSPGtSGSGPTVTHTYLSPGTYTVTLTASNAVGSANA 70
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 1058-1128 2.45e-11

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 62.13  E-value: 2.45e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530408236 1058 TNRSAQFEAATSPSPRRVAYHWDFGDGSpGQDTDEPRAEHSYLRPGDYRVQVNASNLVSfFVAQATVTVQV 1128
Cdd:cd00146    13 LGASVTFSASDSSGGSIVSYKWDFGDGE-VSSSGEPTVTHTYTKPGTYTVTLTVTNAVG-SSSTKTTTVVV 81
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 537-613 6.19e-11

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 60.97  E-value: 6.19e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530408236  537 VVNASRTVVPLNGSVSFS-TSLEAGSDVRYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIVTAENEVGSAQ-DSIFVYV 613
Cdd:cd00146     3 ASVSAPPVAELGASVTFSaSDSSGGSIVSYKWDFGDGEVSSSGEPTVTHTYTKPGTYTVTLTVTNAVGSSStKTTTVVV 81
GPS smart00303
G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin ...
 1996-2045 1.92e-10

G-protein-coupled receptor proteolytic site domain; Present in latrophilin/CL-1, sea urchin REJ and polycystin.


Pssm-ID: 197639  Cd Length: 49  Bit Score: 58.55  E-value: 1.92e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 530408236   1996 YTSLCQYFSEEDMVWRTEGLLPLEETSpRQAVCLTRHLTAFGASLFVPPS 2045
Cdd:smart00303    1 FNPICVFWDESSGEWSTRGCELLETNG-THTTCSCNHLTTFAVLMDVPPI 49
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 281-362 2.72e-10

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 59.00  E-value: 2.72e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236    281 VLRVEPAACIPTQP-DARLTAYVTGNPAHYLFDWTFGDGssnTTVRGcPTVTHNFTRSGTFPLALVLSSRVNRAHYFTSI 359
Cdd:smart00089    1 VADVSASPTVGVAGeSVTFTATSSDDGSIVSYTWDFGDG---TSSTG-PTVTHTYTKPGTYTVTLTVTNAVGSASATVTV 76


                    ...
gi 530408236    360 CVE 362
Cdd:smart00089   77 VVQ 79
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 392-448 6.11e-10

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 57.85  E-value: 6.11e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 530408236    392 PFPYRYTWDFGTEeaapTRARGPEVTFIYRDPGSYLVTVTASNNISAANDSALVEVQ 448
Cdd:smart00089   27 GSIVSYTWDFGDG----TSSTGPTVTHTYTKPGTYTVTLTVTNAVGSASATVTVVVQ 79
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 630-697 4.99e-09

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 55.54  E-value: 4.99e-09
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530408236    630 PTNHTVQLQAVVR-DGTNVSYSWtawrDRGPALAGSGKGFSLTVLEAGTYHVQLRATNMLGSAWADCTM 697
Cdd:smart00089   12 VAGESVTFTATSSdDGSIVSYTW----DFGDGTSSTGPTVTHTYTKPGTYTVTLTVTNAVGSASATVTV 76
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 207-266 6.15e-09

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 55.20  E-value: 6.15e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530408236  207 AVEQGAPVVVSAAVQ-TGDNITWTFDMGDGTVLSGPEATVEHVYLRAQNCTVTVGAASPAG 266
Cdd:cd00146    10 VAELGASVTFSASDSsGGSIVSYKWDFGDGEVSSSGEPTVTHTYTKPGTYTVTLTVTNAVG 70
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 211-277 1.18e-08

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 54.38  E-value: 1.18e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530408236    211 GAPVVVSAAVQT-GDNITWTFDMGDGTVLSGPeaTVEHVYLRAQNCTVTVGAASPAGHLARSLHVLVF 277
Cdd:smart00089   14 GESVTFTATSSDdGSIVSYTWDFGDGTSSTGP--TVTHTYTKPGTYTVTLTVTNAVGSASATVTVVVQ 79
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 465-529 3.64e-08

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 52.88  E-value: 3.64e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  465 ELQQPYLFSAV--GRGRPASYLWDLGDGGWL--EGPEVTHAYNSTGDFTVRVAGWNEVSRSEA-WLNVTV 529
Cdd:cd00146    12 ELGASVTFSASdsSGGSIVSYKWDFGDGEVSssGEPTVTHTYTKPGTYTVTLTVTNAVGSSSTkTTTVVV 81
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 792-863 3.83e-08

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 52.88  E-value: 3.83e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530408236  792 IRASEPGGSFVAAGSSVPFWGQLATG---TNVSWCWAVPGGSSKRGPHVTMVFPDAGTFSIRLNASNAVSWVSAT 863
Cdd:cd00146     1 PTASVSAPPVAELGASVTFSASDSSGgsiVSYKWDFGDGEVSSSGEPTVTHTYTKPGTYTVTLTVTNAVGSSSTK 75
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
125-335 3.91e-08

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 58.14  E-value: 3.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  125 AGRPVTFYPHplpSPGGVL-YTWDFGDGSpvlTQSQPAANHTYASRGTYHVRLEVNNTV-SGAAAQADVRVFEELRGLSV 202
Cdd:COG3291    10 APLTVQFTDT---SSGNATsYEWDFGDGT---TSTEANPSHTYTTPGTYTVTLTVTDAAgCSDTTTKTITVGAPNPGVTT 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  203 DMSLAVEQGAPVVVSAAVQTGDNITWTFDMGDGTVLSGPEATVEHVYLRAQNCTVTVGAASPAGHLARSLHVLVFVLEVL 282
Cdd:COG3291    84 VTTSTTVTTLANTANGGATTVVAGSTVGTGVATSTTTAAAPGGGGGTGTTTTTGTDTGLTGSTGTASDTATVTTSVSTTD 163

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 530408236  283 RVEPAACIPTQPDARLTAYVTGNPAHYLFDWTFGDGSSNTTVRGCPTVTHNFT 335
Cdd:COG3291   164 VTSDGTTSASTNPSVTTDTVTTLTGSYTGTIVGGSGSGTVTSGTAGVTTGATS 216
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 9-101 3.98e-08

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 52.39  E-value: 3.98e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236     9 VSTVPAVLSPNATLALTAGVLvdSAVEVAFLWTFGDgeqalhqfqppynesfpvpdpSVAQVLVEHNVMHTYAAPGEYLL 88
Cdd:pfam00801    1 VSASGTVVAAGQPVTFTATLA--DGSNVTYTWDFGD---------------------SPGTSGSGPTVTHTYLSPGTYTV 57

                           90
                   ....*....|...
gi 530408236    89 TVLASNAFENLTQ 101
Cdd:pfam00801   58 TLTASNAVGSANA 70
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 708-781 9.49e-08

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 51.73  E-value: 9.49e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530408236  708 VAASPNPAA-VNTSVTLSAE-LAGGSGVVYTWSLEEGLSWETSEPFTTHSFPTPGLHLVTMTAGNPLGSAN---ATVEV 781
Cdd:cd00146     3 ASVSAPPVAeLGASVTFSASdSSGGSIVSYKWDFGDGEVSSSGEPTVTHTYTKPGTYTVTLTVTNAVGSSStktTTVVV 81
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 2105-2212 9.87e-08

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 53.31  E-value: 9.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236 2105 YEILVKTGWGRGSGTTAHVGIMLYGVDSRS---------GHRHLDGDRAFHRNSLDIFRIATPHSLGSVWKIRVWHDNKG 2175
Cdd:cd01754     3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGlrianleawGGLMGAGHDYFERGNLDRFSGRGPCLPSPPCWMNLTSDGTG 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 530408236 2176 LSPAWFLQHVIVRDL-QTARSA--FFLVNDWLSVETEANG 2212
Cdd:cd01754    83 NHPGWYVNYVEVTQAgQHAPCMqhLFAVEQWLATDESPYM 122
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 6-107 1.23e-07

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 51.30  E-value: 1.23e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236      6 GLQVSTVPAVLSPNATLALTAGVLVDSAVeVAFLWTFGDGeqalhqfqppynesfpvpdpsvaQVLVEHNVMHTYAAPGE 85
Cdd:smart00089    1 VADVSASPTVGVAGESVTFTATSSDDGSI-VSYTWDFGDG-----------------------TSSTGPTVTHTYTKPGT 56

                            90       100
                    ....*....|....*....|..
gi 530408236     86 YLLTVLASNAFENLTQQVPVSV 107
Cdd:smart00089   57 YTVTLTVTNAVGSASATVTVVV 78
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 137-193 1.58e-07

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 51.12  E-value: 1.58e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 530408236   137 PSPGGVL-YTWDFGDGSpvlTQSQPAANHTYASRGTYHVRLEVNNTVSGAAAQADVRV 193
Cdd:pfam18911   29 DPDGDILsYRWDFGDGT---TATGANVSHTYAAPGTYTVTLTVTDDSGASNSTATDTV 83
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 289-354 2.41e-07

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 50.46  E-value: 2.41e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530408236   289 CIPTQPDARLTAYV-TGNPAHYLfdWTFGDgsSNTTVRGCPTVTHNFTRSGTFPLALVLSSRVNRAH 354
Cdd:pfam00801    7 VVAAGQPVTFTATLaDGSNVTYT--WDFGD--SPGTSGSGPTVTHTYLSPGTYTVTLTASNAVGSAN 69
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 292-365 2.73e-07

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 50.57  E-value: 2.73e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530408236  292 TQPDARLTAYVTGNPAHYLFDWTFGDGssNTTVRGCPTVTHNFTRSGTFPLALVLSSRVNRAhyfTSICVEPEV 365
Cdd:cd00146    13 LGASVTFSASDSSGGSIVSYKWDFGDG--EVSSSGEPTVTHTYTKPGTYTVTLTVTNAVGSS---STKTTTVVV 81
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 873-952 4.44e-07

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 49.76  E-value: 4.44e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236    873 VGLVLWASSKVVApGQLVHFQI-LLAAGSAVTFRLQVGgaNPEVLPGPRFSHSFPRVGDHVVSVRGKNHVSWAQAQVRIV 951
Cdd:smart00089    1 VADVSASPTVGVA-GESVTFTAtSSDDGSIVSYTWDFG--DGTSSTGPTVTHTYTKPGTYTVTLTVTNAVGSASATVTVV 77


                    .
gi 530408236    952 V 952
Cdd:smart00089   78 V 78
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 394-447 1.07e-06

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 48.65  E-value: 1.07e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 530408236  394 PYRYTWDFGTEEAAPTRarGPEVTFIYRDPGSYLVTVTASNNISAAN-DSALVEV 447
Cdd:cd00146    29 IVSYKWDFGDGEVSSSG--EPTVTHTYTKPGTYTVTLTVTNAVGSSStKTTTVVV 81
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 472-512 2.00e-06

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 48.04  E-value: 2.00e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 530408236   472 FSAVGRGRPASYLWDLGDGGWLEGPEVTHAYNSTGDFTVRV 512
Cdd:pfam18911   26 ASDDPDGDILSYRWDFGDGTTATGANVSHTYAAPGTYTVTL 66
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
710-887 2.93e-06

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 52.36  E-value: 2.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  710 ASPNPAAVNTSVTLSAeLAGGSGVVYTWSLEEGLSweTSEPFTTHSFPTPGLHLVTMTAGNPLGSANA-----TVEVDVQ 784
Cdd:COG3291     3 ATPTSGCAPLTVQFTD-TSSGNATSYEWDFGDGTT--STEANPSHTYTTPGTYTVTLTVTDAAGCSDTttktiTVGAPNP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  785 VPVSGLSIRASEPGGSFVAAGSSVPFWGQLATGTNVSWCWAVPGGSSKRGPHVTMVFPDAGTFSIRLNASNAVSWVSATY 864
Cdd:COG3291    80 GVTTVTTSTTVTTLANTANGGATTVVAGSTVGTGVATSTTTAAAPGGGGGTGTTTTTGTDTGLTGSTGTASDTATVTTSV 159

                         170       180
                  ....*....|....*....|...
gi 530408236  865 NLTAEEPIVGLVLWASSKVVAPG 887
Cdd:COG3291   160 STTDVTSDGTTSASTNPSVTTDT 182
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
393-694 6.36e-06

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 51.21  E-value: 6.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  393 FPYRYTWDFGTeeaaPTRARGPEVTFIYRDPGSYLVTVTASNNI-SAANDSALVEVQEPVLVTSIKVNGSlglelqqpYL 471
Cdd:COG3291    23 NATSYEWDFGD----GTTSTEANPSHTYTTPGTYTVTLTVTDAAgCSDTTTKTITVGAPNPGVTTVTTST--------TV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  472 FSAVGRGRPASYLWDLGDGGWLEGPEVTHAYNSTGDFTVRVAGWNEVSRSEAWLNVTVKRRVRGLVVNASRTVVPLNGSV 551
Cdd:COG3291    91 TTLANTANGGATTVVAGSTVGTGVATSTTTAAAPGGGGGTGTTTTTGTDTGLTGSTGTASDTATVTTSVSTTDVTSDGTT 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  552 SFSTSLEAGSDVRYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIVTAENEVGSAQDSIFVYVLQLIEGLQVVGGGRYFPT 631
Cdd:COG3291   171 SASTNPSVTTDTVTTLTGSYTGTIVGGSGSGTVTSGTAGVTTGATSGTSGTGSATSGVAVTDVTLTGISTGDAGTPGTNT 250

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530408236  632 NHTVQLQAVVRDGTNVSYSWTAWRDRGPALAGSGKGFSLTVLEAGTYHVQLRATNMLGSAWAD 694
Cdd:COG3291   251 VTTSGANTAGTSTITGGTSGVVTTSAATGTSTNGTGGLGTTTAITPGNVSTTADVTGGTATLA 313
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 396-447 1.94e-05

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 45.34  E-value: 1.94e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 530408236   396 RYTWDFGTEeaapTRARGPEVTFIYRDPGSYLVTVTASNNISAANDSALVEV 447
Cdd:pfam18911   36 SYRWDFGDG----TTATGANVSHTYAAPGTYTVTLTVTDDSGASNSTATDTV 83
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
10-369 2.90e-05

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 49.28  E-value: 2.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   10 STVPAVLSPNATLALTAgvlVDSAVEVAFLWTFGDGEQAlhqfqppynesfpvpdpsvaqvlVEHNVMHTYAAPGEYLLT 89
Cdd:COG3291     2 TATPTSGCAPLTVQFTD---TSSGNATSYEWDFGDGTTS-----------------------TEANPSHTYTTPGTYTVT 55

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   90 VLASNAF-ENLTQQVPVSVRASLPSVAVGVSDGVLVAGRPVTFYPHPLPSPGGVLYTWDFGDGSPVLTQSQPAANHTYAS 168
Cdd:COG3291    56 LTVTDAAgCSDTTTKTITVGAPNPGVTTVTTSTTVTTLANTANGGATTVVAGSTVGTGVATSTTTAAAPGGGGGTGTTTT 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  169 RGTYHVRLEVNNTVSGAAAQADVRVFEELRGLSVDmslaveqGAPVVVSAAVQTGDNITWTFDMGDGTVLSGPEATVEHV 248
Cdd:COG3291   136 TGTDTGLTGSTGTASDTATVTTSVSTTDVTSDGTT-------SASTNPSVTTDTVTTLTGSYTGTIVGGSGSGTVTSGTA 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  249 YLRAQNCTVTVGAASPAGHLARSLHVLVFVLEVLRVEPAACIPTQPDARLTAYVTGNPAHYLFDWTFGDGSSNTTVRGCP 328
Cdd:COG3291   209 GVTTGATSGTSGTGSATSGVAVTDVTLTGISTGDAGTPGTNTVTTSGANTAGTSTITGGTSGVVTTSAATGTSTNGTGGL 288

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 530408236  329 TVTHNFTRSGTFPLALVLSSRVNRAHYFTSICVEPEVGNVT 369
Cdd:COG3291   289 GTTTAITPGNVSTTADVTGGTATLAVSSTLTTNDTTGSSST 329
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 967-1043 3.36e-05

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 44.36  E-value: 3.36e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530408236    967 PGIATGTERNFTARVQR-GSRVAYAWYFslqkvqGDSLViLSGRDVTYTPVAAGLLEIQVRAFNALGSENRTLVLEVQ 1043
Cdd:smart00089    9 TVGVAGESVTFTATSSDdGSIVSYTWDF------GDGTS-STGPTVTHTYTKPGTYTVTLTVTNAVGSASATVTVVVQ 79
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 876-952 4.01e-05

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 44.41  E-value: 4.01e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530408236  876 VLWASSKVVAPGQLVHFQI-LLAAGSAVTFRLQVGGANPEVLPGPRFSHSFPRVGDHVVSVRGKNHVSWAQAQVRIVV 952
Cdd:cd00146     3 ASVSAPPVAELGASVTFSAsDSSGGSIVSYKWDFGDGEVSSSGEPTVTHTYTKPGTYTVTLTVTNAVGSSSTKTTTVV 80
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
1061-1127 5.90e-05

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 48.13  E-value: 5.90e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530408236 1061 SAQFEAATSPSPrrVAYHWDFGDGSpgqDTDEPRAEHSYLRPGDYRVQVNASNLV-SFFVAQATVTVQ 1127
Cdd:COG3291    13 TVQFTDTSSGNA--TSYEWDFGDGT---TSTEANPSHTYTTPGTYTVTLTVTDAAgCSDTTTKTITVG 75
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 1061-1113 6.84e-05

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 43.80  E-value: 6.84e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 530408236  1061 SAQFEAATS--PSPRRVAYHWDFGDGSPGqdtDEPRAEHSYLRPGDYRVQVNASN 1113
Cdd:pfam18911   19 TVTFDASASddPDGDILSYRWDFGDGTTA---TGANVSHTYAAPGTYTVTLTVTD 70
PksD COG3321
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
 2741-3266 7.86e-05

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 48.72  E-value: 7.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236 2741 EALYPDPPGPRV--------HTCSAAGGFSTSDYDVGWESPHNGSGTWAYSAPDLLGAWSWGSCAVYDSGGYVQELGLSL 2812
Cdd:COG3321   850 SALYPGRGRRRVplptypfqREDAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALALAAAALAAL 929

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236 2813 EESRDRLRFLQLHNWLDNRSRAVFLELTRYSPAVGLHAAVTLRLEFPAAGRALAALSVRPFALRRLSAGLSLPLLTSVCL 2892
Cdd:COG3321   930 LALVALAAAAAALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAALALLAAAA 1009

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236 2893 LLFAVHFAVAEARTWHREGRWRVLRLGAWARWLLVALTAATALVRLAQLGAADRQWTRFVRGRPRRFTSFDQVAQLSSAA 2972
Cdd:COG3321  1010 LLLAAAAAAAALLALAALLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELALAAAALALAAA 1089

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236 2973 RGLAASLLFLLLVKAAQQLRFVRQWSVFGKTLCRALPELLGVTLGLVVLGVAYAQLAILLVSSCVDSLWSVAQALLVLCP 3052
Cdd:COG3321  1090 LAAAALALALAALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAALAAALAAALLA 1169

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236 3053 GTGLSTLCPAESWHLSPLLCVGLWALRLWGALRLGAVILRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGLSKVK 3132
Cdd:COG3321  1170 AAALLLALALALAAALAAALAGLAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALALLALAAAAAAVAALA 1249

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236 3133 EFRHKVRFEGMEPLPSRSSRGSKVSPDVPPPSAGSDASHPSTSSSQLDGLSVSLGRLGTRCEPEPSRLQAVFEALLTQFD 3212
Cdd:COG3321  1250 AAAAALLAALAALALLAAAAGLAALAAAAAAAAAALALAAAAAAAAAALAALLAAAAAAAAAAAAAAAAAALAAALLAAA 1329

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 530408236 3213 RLNQA-TEDVYQLEQQLHSLQGRRSSRAPAGSSRGPSPGLRPALPSRLARASRGV 3266
Cdd:COG3321  1330 LAALAaAVAAALALAAAAAAAAAAAAAAAAAAALAAAAGAAAAAAALALAALAAA 1384
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 628-700 7.57e-04

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 40.94  E-value: 7.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236  628 YFPTNHTVQLQAVVR-------DGTNVSYSWTaWRDrGPALAGSGKGFSLTVLEAGTYHVQLRATNMLGSAWADCTMDFV 700
Cdd:cd00146     4 SVSAPPVAELGASVTfsasdssGGSIVSYKWD-FGD-GEVSSSGEPTVTHTYTKPGTYTVTLTVTNAVGSSSTKTTTVVV 81
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 708-785 1.81e-03

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 39.95  E-value: 1.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530408236   708 VAASPNPAAVNTSVTLSAE---LAGGSGVVYTWSLEEGLSWETSEPftTHSFPTPGLHLVTMTAGNPLGSANATVEVDVQ 784
Cdd:pfam18911    7 DAGGDRIVAEGETVTFDASasdDPDGDILSYRWDFGDGTTATGANV--SHTYAAPGTYTVTLTVTDDSGASNSTATDTVT 84


                   .
gi 530408236   785 V 785
Cdd:pfam18911   85 V 85
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 222-259 8.44e-03

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 38.02  E-value: 8.44e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 530408236   222 TGDNITWTFDMGDGTVLSGpeATVEHVYLRAQNCTVTV 259
Cdd:pfam18911   31 DGDILSYRWDFGDGTTATG--ANVSHTYAAPGTYTVTL 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH