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Conserved domains on  [gi|530389541|ref|XP_005272381|]
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vacuolar protein sorting-associated protein 28 homolog isoform X1 [Homo sapiens]

Protein Classification

ESCRT-I complex subunit VPS28( domain architecture ID 10512640)

ESCRT-I complex subunit VPS28 (vacuolar protein sorting-associated protein 28) is a component of the endosomal sorting complex required for transport I, which is a regulator of vesicular trafficking processes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VPS28 pfam03997
VPS28 protein;
39-202 1.08e-85

VPS28 protein;


:

Pssm-ID: 427639  Cd Length: 187  Bit Score: 250.89  E-value: 1.08e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389541   39 MAELFAVVKTMQALEKAYIKDCVSPSE------------------QVQgSEISSIDEFCRKFRLDCPLAMERIKEDRPIT 100
Cdd:pfam03997   1 LAELYSIIVTLEHLEKAYIKDSITAKEytstcsrllaqyktildeLVK-DEFPDLEEFMKKYRLDCPAALERLREGVPAT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389541  101 IKD------DKGNLNRCIADVVSLFITVMDKLRLEIRAMDEIQPDLRELMETMHRMSHLPPDFEGRQTVSQWLQTLSGMS 174
Cdd:pfam03997  80 VEHsasssaDGGNSAKLVAEATQNFITLMDALKLNYRAKDQLHPLLSDLLQSLNKLSLLPPDFEGKSKLVKWLIKLNNMK 159

                         170       180
                  ....*....|....*....|....*...
gi 530389541  175 ASDELDDSQVRQMLFDLESAYNAFNRFL 202
Cdd:pfam03997 160 ASDELSEEQARQLLFDLESAYNAFYRSL 187
 
Name Accession Description Interval E-value
VPS28 pfam03997
VPS28 protein;
39-202 1.08e-85

VPS28 protein;


Pssm-ID: 427639  Cd Length: 187  Bit Score: 250.89  E-value: 1.08e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389541   39 MAELFAVVKTMQALEKAYIKDCVSPSE------------------QVQgSEISSIDEFCRKFRLDCPLAMERIKEDRPIT 100
Cdd:pfam03997   1 LAELYSIIVTLEHLEKAYIKDSITAKEytstcsrllaqyktildeLVK-DEFPDLEEFMKKYRLDCPAALERLREGVPAT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389541  101 IKD------DKGNLNRCIADVVSLFITVMDKLRLEIRAMDEIQPDLRELMETMHRMSHLPPDFEGRQTVSQWLQTLSGMS 174
Cdd:pfam03997  80 VEHsasssaDGGNSAKLVAEATQNFITLMDALKLNYRAKDQLHPLLSDLLQSLNKLSLLPPDFEGKSKLVKWLIKLNNMK 159

                         170       180
                  ....*....|....*....|....*...
gi 530389541  175 ASDELDDSQVRQMLFDLESAYNAFNRFL 202
Cdd:pfam03997 160 ASDELSEEQARQLLFDLESAYNAFYRSL 187
 
Name Accession Description Interval E-value
VPS28 pfam03997
VPS28 protein;
39-202 1.08e-85

VPS28 protein;


Pssm-ID: 427639  Cd Length: 187  Bit Score: 250.89  E-value: 1.08e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389541   39 MAELFAVVKTMQALEKAYIKDCVSPSE------------------QVQgSEISSIDEFCRKFRLDCPLAMERIKEDRPIT 100
Cdd:pfam03997   1 LAELYSIIVTLEHLEKAYIKDSITAKEytstcsrllaqyktildeLVK-DEFPDLEEFMKKYRLDCPAALERLREGVPAT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530389541  101 IKD------DKGNLNRCIADVVSLFITVMDKLRLEIRAMDEIQPDLRELMETMHRMSHLPPDFEGRQTVSQWLQTLSGMS 174
Cdd:pfam03997  80 VEHsasssaDGGNSAKLVAEATQNFITLMDALKLNYRAKDQLHPLLSDLLQSLNKLSLLPPDFEGKSKLVKWLIKLNNMK 159

                         170       180
                  ....*....|....*....|....*...
gi 530389541  175 ASDELDDSQVRQMLFDLESAYNAFNRFL 202
Cdd:pfam03997 160 ASDELSEEQARQLLFDLESAYNAFYRSL 187
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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