|
Name |
Accession |
Description |
Interval |
E-value |
| DEXXQc_Helz-like |
cd18038 |
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and ... |
494-730 |
7.07e-124 |
|
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and similar proteins. Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. All are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350796 [Multi-domain] Cd Length: 229 Bit Score: 375.42 E-value: 7.07e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 494 NEEQCRAVTHIVTGMSRPAPYLIFGPPGTGKTVTLVEAIKQVWTCFKDARILACAPSNSAADLLCQRLIKDIA-PRYIYR 572
Cdd:cd18038 3 NDEQKLAVRNIVTGTSRPPPYIIFGPPGTGKTVTLVEAILQVLRQPPEARILVCAPSNSAADLLAERLLNALVtKREILR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 573 LIASSRSYQEVPADIRPCCNWDDqQSCYVYPNKEHLGRYRILITTLVTAGRLVSANFPPGYFSHVFIDECGQAVEPESLI 652
Cdd:cd18038 83 LNAPSRDRASVPPELLPYCNSKA-EGTFRLPSLEELKKYRIVVCTLMTAGRLVQAGVPNGHFTHIFIDEAGQATEPEALI 161
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2728217431 653 AIAGLLTAmdqetnpnGGQLVLAGDPQQLGPVLRSPLAIEHGLGTSLLERLMLHNPLYKrsSGGYNPQFVTKLLWNYR 730
Cdd:cd18038 162 PLSELASK--------NTQIVLAGDPKQLGPVVRSPLARKYGLGKSLLERLMERPLYYK--DGEYNPSYITKLLKNYR 229
|
|
| SF1_C_Upf1 |
cd18808 |
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family ... |
731-938 |
5.54e-67 |
|
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350195 [Multi-domain] Cd Length: 184 Bit Score: 222.11 E-value: 5.54e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 731 SHEAILRIPNELFYDSELKPCQTDELDVRnlycaWEELPKKGFPIIFHGVCGEDRREAKSPSFFNTAEIEVLVHYLQKLL 810
Cdd:cd18808 1 MHPEISEFPSKLFYEGKLKAGVSVAARLN-----PPPLPGPSKPLVFVDVSGGEEREESGTSKSNEAEAELVVELVKYLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 811 QSRgkrgcptISPKEIGIISPYRKQVEKIRKAITSLDPVLRKLpdikllKVGSVEEFQGQERRVILISTVRSCSEYLqfd 890
Cdd:cd18808 76 KSG-------VKPSSIGVITPYRAQVALIRELLRKRGGLLEDV------EVGTVDNFQGREKDVIILSLVRSNESGG--- 139
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 2728217431 891 qtfKLGFLKNPKRLNVAITRAKALLIVVGNPAVLSKDHHWQRFLRYCK 938
Cdd:cd18808 140 ---SIGFLSDPRRLNVALTRAKRGLIIVGNPDTLSKDPLWKKLLEYLE 184
|
|
| AAA_12 |
pfam13087 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
695-921 |
3.01e-62 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 463780 [Multi-domain] Cd Length: 196 Bit Score: 209.33 E-value: 3.01e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 695 LGTSLLERLMLHNPlykrssggynpQFVTKLLWNYRSHEAILRIPNELFYDSELKPCqtDELDVRNLYCaWEELPKKGFP 774
Cdd:pfam13087 1 LDRSLFERLQELGP-----------SAVVMLDTQYRMHPEIMEFPSKLFYGGKLKDG--PSVAERPLPD-DFHLPDPLGP 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 775 IIFHGV-CGEDRREAKSPSFFNTAEIEVLVHYLQKLLQSRGKRgcptisPKEIGIISPYRKQVEKIRKAITsldpvlRKL 853
Cdd:pfam13087 67 LVFIDVdGSEEEESDGGTSYSNEAEAELVVQLVEKLIKSGPEE------PSDIGVITPYRAQVRLIRKLLK------RKL 134
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2728217431 854 PDIKLLKVGSVEEFQGQERRVILISTVRSCseylqfdQTFKLGFLKNPKRLNVAITRAKALLIVVGNP 921
Cdd:pfam13087 135 GGKLEIEVNTVDGFQGREKDVIIFSCVRSN-------EKGGIGFLSDPRRLNVALTRAKRGLIIVGNA 195
|
|
| DNA2 |
COG1112 |
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]; |
608-940 |
2.01e-61 |
|
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];
Pssm-ID: 440729 [Multi-domain] Cd Length: 819 Bit Score: 224.62 E-value: 2.01e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 608 LGRYRILITTLVTAGRLVsaNFPPGYFSHVFIDECGQAVEPESLIAIAglltamdqetnpNGGQLVLAGDPQQLGPVLRS 687
Cdd:COG1112 532 LELAPVVGMTPASVARLL--PLGEGSFDLVIIDEASQATLAEALGALA------------RAKRVVLVGDPKQLPPVVFG 597
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 688 PLAIE---HGLGTSLLERLMlhnplykrssgGYNPQFVTKLLWNYRSHEAILRIPNELFYDSELKPcqtdeldVRNlyCA 764
Cdd:COG1112 598 EEAEEvaeEGLDESLLDRLL-----------ARLPERGVMLREHYRMHPEIIAFSNRLFYDGKLVP-------LPS--PK 657
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 765 WEELPKKGFPIIFHGVCGedRREAKSPSFFNTAEIEVLVHYLQKLLQSRGKrgcptisPKEIGIISPYRKQVEKIRKAIT 844
Cdd:COG1112 658 ARRLADPDSPLVFIDVDG--VYERRGGSRTNPEEAEAVVELVRELLEDGPD-------GESIGVITPYRAQVALIRELLR 728
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 845 SLDPVLRKLpdiklLKVGSVEEFQGQERRVILISTVRSCSEylqfDQTFKLGFL-KNPKRLNVAITRAKALLIVVGNPAV 923
Cdd:COG1112 729 EALGDGLEP-----VFVGTVDRFQGDERDVIIFSLVYSNDE----DVPRNFGFLnGGPRRLNVAVSRARRKLIVVGSREL 799
|
330 340
....*....|....*....|
gi 2728217431 924 LS---KDHHWQRFLRYCKEE 940
Cdd:COG1112 800 LDsdpSTPALKRLLEYLERA 819
|
|
| TIGR00376 |
TIGR00376 |
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of ... |
482-943 |
3.11e-55 |
|
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of this family have been characterized as binding certain single-stranded G-rich DNA sequences (GGGGT and GGGCT). A number of related proteins are characterized as helicases. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273041 [Multi-domain] Cd Length: 636 Bit Score: 203.12 E-value: 3.11e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 482 FQPrwFDRKLqaNEEQCRAVTHIVtgmSRPAPYLIFGPPGTGKTVTLVEAIKQVwtCFKDARILACAPSNSAADLLCQRL 561
Cdd:TIGR00376 151 FQF--FDPNL--NESQKEAVLFAL---SSKDLFLIHGPPGTGKTRTVVELIRQL--VKRGLRVLVTAPSNIAVDNLLERL 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 562 I----------------KDIAPRYIYRLIASSRSYQEVpADIRPCC-------------------NWDDQQ--------- 597
Cdd:TIGR00376 222 AlcdqkivrlghparllKSNKQHSLDYLIENHPKYQIV-ADIREKIdelieernkktkpspqkrrGLSDIKilrkalkkr 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 598 --------------------------SCYVYPNKEHLGRyRILITTLVTAGRLVSANFPPGYFSHVFIDECGQAVEPESL 651
Cdd:TIGR00376 301 eargieslkiasmaewietnksidrlLKLLPESEERIMN-EILAESDATNSMAGSEILNGQYFDVAVIDEASQAMEPSCL 379
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 652 IAIAglltamdqetnpNGGQLVLAGDPQQLGPVLRSPLAieHGLGTSLLERLMlhnPLYkrssggynPQFVTKLLWNYRS 731
Cdd:TIGR00376 380 IPLL------------KARKLILAGDHKQLPPTILSHDA--EELSLTLFERLI---KEY--------PERSRTLNVQYRM 434
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 732 HEAILRIPNELFYDSELKPCQTdeldVRNLycAWEELPKK-----------GFPIIF---HGVCGEDRREAKSPSFFNTA 797
Cdd:TIGR00376 435 NQKIMEFPSREFYNGKLTAHES----VANI--LLRDLPKVeateseddletGIPLLFidtSGCELFELKEADSTSKYNPG 508
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 798 EIEVLVHYLQKLLqsrgKRGCPtisPKEIGIISPYRKQVEKIRKAITsldpvlRKLPDIkllKVGSVEEFQGQERRVILI 877
Cdd:TIGR00376 509 EAELVSEIIQALV----KMGVP---ANDIGVITPYDAQVDLLRQLLE------HRHIDI---EVSSVDGFQGREKEVIII 572
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2728217431 878 STVRScseylqfDQTFKLGFLKNPKRLNVAITRAKALLIVVGNPAVLSKDHHWQRFLRYCKEEGGY 943
Cdd:TIGR00376 573 SFVRS-------NRKGEVGFLKDLRRLNVALTRARRKLIVIGDSRTLSNHKFYKRLIEWCKQHGEV 631
|
|
| AAA_11 |
pfam13086 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
497-688 |
2.01e-19 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 404072 [Multi-domain] Cd Length: 248 Bit Score: 88.94 E-value: 2.01e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 497 QCRAVTHIVtgmSRPAPYLIFGPPGTGKTVTLVEAIKQ-----VWTCFKDARILACAPSNSAADLLCQRLIKDIA----- 566
Cdd:pfam13086 2 QREAIRSAL---SSSHFTLIQGPPGTGKTTTIVELIRQllsypATSAAAGPRILVCAPSNAAVDNILERLLRKGQkygpk 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 567 -------------------PRYIYRLIASSRSYQ--------------EVPADIRPCCNWDDQQSCYVYPNKEH------ 607
Cdd:pfam13086 79 ivrighpaaiseavlpvslDYLVESKLNNEEDAQivkdiskeleklakALRAFEKEIIVEKLLKSRNKDKSKLEqerrkl 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 608 ----------------------LGRYRILITTLVTAGRLVSANFPPgyFSHVFIDECGQAVEPESLIAiagLLTAmdqet 665
Cdd:pfam13086 159 rserkelrkelrrreqslereiLDEAQIVCSTLSGAGSRLLSSLAN--FDVVIIDEAAQALEPSTLIP---LLRG----- 228
|
250 260
....*....|....*....|...
gi 2728217431 666 npnGGQLVLAGDPQQLGPVLRSP 688
Cdd:pfam13086 229 ---PKKVVLVGDPKQLPPTVISK 248
|
|
| RecD |
COG0507 |
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ... |
485-684 |
8.44e-10 |
|
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440273 [Multi-domain] Cd Length: 514 Bit Score: 62.30 E-value: 8.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 485 RWFDRK-LQANEEQCRAVTHIVTGmSRPApyLIFGPPGTGKTvTLVEAIKQVWTcFKDARILACAPSNSAAdllcQRLIK 563
Cdd:COG0507 116 ALEPRAgITLSDEQREAVALALTT-RRVS--VLTGGAGTGKT-TTLRALLAALE-ALGLRVALAAPTGKAA----KRLSE 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 564 DIAPRY--IYRLIAssrsyqevpadirpccnWDDQQSCYVYPNKEHLGRYRILIttlvtagrlvsanfppgyfshvfIDE 641
Cdd:COG0507 187 STGIEArtIHRLLG-----------------LRPDSGRFRHNRDNPLTPADLLV-----------------------VDE 226
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 2728217431 642 CgqavepeSLIAIAgLLTAMDQETNPNGGQLVLAGDPQQLGPV 684
Cdd:COG0507 227 A-------SMVDTR-LMAALLEALPRAGARLILVGDPDQLPSV 261
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
497-642 |
2.93e-04 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 43.25 E-value: 2.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 497 QCRAVTHIVTGMSRpapYLIFGPPGTGKTVTLVEAIKQVWTCFKDARILACAPSNSAADLLCQRLIK---DIAPRYIYRL 573
Cdd:smart00487 13 QKEAIEALLSGLRD---VILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKlgpSLGLKVVGLY 89
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 574 IASSRSYQEvpadirpccnwddqqscyvypNKEHLGRYRILITTLVTAGRLVSAN-FPPGYFSHVFIDEC 642
Cdd:smart00487 90 GGDSKREQL---------------------RKLESGKTDILVTTPGRLLDLLENDkLSLSNVDLVILDEA 138
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DEXXQc_Helz-like |
cd18038 |
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and ... |
494-730 |
7.07e-124 |
|
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and similar proteins. Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. All are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350796 [Multi-domain] Cd Length: 229 Bit Score: 375.42 E-value: 7.07e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 494 NEEQCRAVTHIVTGMSRPAPYLIFGPPGTGKTVTLVEAIKQVWTCFKDARILACAPSNSAADLLCQRLIKDIA-PRYIYR 572
Cdd:cd18038 3 NDEQKLAVRNIVTGTSRPPPYIIFGPPGTGKTVTLVEAILQVLRQPPEARILVCAPSNSAADLLAERLLNALVtKREILR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 573 LIASSRSYQEVPADIRPCCNWDDqQSCYVYPNKEHLGRYRILITTLVTAGRLVSANFPPGYFSHVFIDECGQAVEPESLI 652
Cdd:cd18038 83 LNAPSRDRASVPPELLPYCNSKA-EGTFRLPSLEELKKYRIVVCTLMTAGRLVQAGVPNGHFTHIFIDEAGQATEPEALI 161
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2728217431 653 AIAGLLTAmdqetnpnGGQLVLAGDPQQLGPVLRSPLAIEHGLGTSLLERLMLHNPLYKrsSGGYNPQFVTKLLWNYR 730
Cdd:cd18038 162 PLSELASK--------NTQIVLAGDPKQLGPVVRSPLARKYGLGKSLLERLMERPLYYK--DGEYNPSYITKLLKNYR 229
|
|
| DEXXQc_Mov10L1 |
cd18078 |
DEXXQ-box helicase domain of Mov10L1; Moloney leukemia virus 10-like protein 1 (Mov10L1) binds ... |
494-730 |
6.56e-83 |
|
DEXXQ-box helicase domain of Mov10L1; Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. Mov10L1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350836 [Multi-domain] Cd Length: 230 Bit Score: 267.31 E-value: 6.56e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 494 NEEQCRAVTHIVTGMSRPAPYLIFGPPGTGKTVTLVEAIKQVWTCFKDARILACAPSNSAADLLCQRLI--KDIAPRYIY 571
Cdd:cd18078 3 NELQKEAVKRILGGECRPLPYILFGPPGTGKTVTIIEAILQVVYNLPRSRILVCAPSNSAADLVTSRLHesKVLKPGDMV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 572 RLIASSRSYQEVPADIRPCCNWDDQqscyvypnKEHLGRYRILITTLVTAGRLVSANFPPGYFSHVFIDECGQAVEPESL 651
Cdd:cd18078 83 RLNAVNRFESTVIDARKLYCRLGED--------LSKASRHRIVISTCSTAGLLYQMGLPVGHFTHVFVDEAGQATEPESL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 652 IAIaGLLTAmdqetnpNGGQLVLAGDPQQLGPVLRSPLAIEHGLGTSLLERLMLhNPLYKR------SSGGYNPQFVTKL 725
Cdd:cd18078 155 IPL-GLISS-------RDGQIILAGDPMQLGPVIKSRLASAYGLGVSFLERLMN-RPLYLRdpnrfgESGGYNPLLVTKL 225
|
....*
gi 2728217431 726 LWNYR 730
Cdd:cd18078 226 VDNYR 230
|
|
| SF1_C_Upf1 |
cd18808 |
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family ... |
731-938 |
5.54e-67 |
|
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350195 [Multi-domain] Cd Length: 184 Bit Score: 222.11 E-value: 5.54e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 731 SHEAILRIPNELFYDSELKPCQTDELDVRnlycaWEELPKKGFPIIFHGVCGEDRREAKSPSFFNTAEIEVLVHYLQKLL 810
Cdd:cd18808 1 MHPEISEFPSKLFYEGKLKAGVSVAARLN-----PPPLPGPSKPLVFVDVSGGEEREESGTSKSNEAEAELVVELVKYLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 811 QSRgkrgcptISPKEIGIISPYRKQVEKIRKAITSLDPVLRKLpdikllKVGSVEEFQGQERRVILISTVRSCSEYLqfd 890
Cdd:cd18808 76 KSG-------VKPSSIGVITPYRAQVALIRELLRKRGGLLEDV------EVGTVDNFQGREKDVIILSLVRSNESGG--- 139
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 2728217431 891 qtfKLGFLKNPKRLNVAITRAKALLIVVGNPAVLSKDHHWQRFLRYCK 938
Cdd:cd18808 140 ---SIGFLSDPRRLNVALTRAKRGLIIVGNPDTLSKDPLWKKLLEYLE 184
|
|
| AAA_12 |
pfam13087 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
695-921 |
3.01e-62 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 463780 [Multi-domain] Cd Length: 196 Bit Score: 209.33 E-value: 3.01e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 695 LGTSLLERLMLHNPlykrssggynpQFVTKLLWNYRSHEAILRIPNELFYDSELKPCqtDELDVRNLYCaWEELPKKGFP 774
Cdd:pfam13087 1 LDRSLFERLQELGP-----------SAVVMLDTQYRMHPEIMEFPSKLFYGGKLKDG--PSVAERPLPD-DFHLPDPLGP 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 775 IIFHGV-CGEDRREAKSPSFFNTAEIEVLVHYLQKLLQSRGKRgcptisPKEIGIISPYRKQVEKIRKAITsldpvlRKL 853
Cdd:pfam13087 67 LVFIDVdGSEEEESDGGTSYSNEAEAELVVQLVEKLIKSGPEE------PSDIGVITPYRAQVRLIRKLLK------RKL 134
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2728217431 854 PDIKLLKVGSVEEFQGQERRVILISTVRSCseylqfdQTFKLGFLKNPKRLNVAITRAKALLIVVGNP 921
Cdd:pfam13087 135 GGKLEIEVNTVDGFQGREKDVIIFSCVRSN-------EKGGIGFLSDPRRLNVALTRAKRGLIIVGNA 195
|
|
| DNA2 |
COG1112 |
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]; |
608-940 |
2.01e-61 |
|
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];
Pssm-ID: 440729 [Multi-domain] Cd Length: 819 Bit Score: 224.62 E-value: 2.01e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 608 LGRYRILITTLVTAGRLVsaNFPPGYFSHVFIDECGQAVEPESLIAIAglltamdqetnpNGGQLVLAGDPQQLGPVLRS 687
Cdd:COG1112 532 LELAPVVGMTPASVARLL--PLGEGSFDLVIIDEASQATLAEALGALA------------RAKRVVLVGDPKQLPPVVFG 597
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 688 PLAIE---HGLGTSLLERLMlhnplykrssgGYNPQFVTKLLWNYRSHEAILRIPNELFYDSELKPcqtdeldVRNlyCA 764
Cdd:COG1112 598 EEAEEvaeEGLDESLLDRLL-----------ARLPERGVMLREHYRMHPEIIAFSNRLFYDGKLVP-------LPS--PK 657
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 765 WEELPKKGFPIIFHGVCGedRREAKSPSFFNTAEIEVLVHYLQKLLQSRGKrgcptisPKEIGIISPYRKQVEKIRKAIT 844
Cdd:COG1112 658 ARRLADPDSPLVFIDVDG--VYERRGGSRTNPEEAEAVVELVRELLEDGPD-------GESIGVITPYRAQVALIRELLR 728
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 845 SLDPVLRKLpdiklLKVGSVEEFQGQERRVILISTVRSCSEylqfDQTFKLGFL-KNPKRLNVAITRAKALLIVVGNPAV 923
Cdd:COG1112 729 EALGDGLEP-----VFVGTVDRFQGDERDVIIFSLVYSNDE----DVPRNFGFLnGGPRRLNVAVSRARRKLIVVGSREL 799
|
330 340
....*....|....*....|
gi 2728217431 924 LS---KDHHWQRFLRYCKEE 940
Cdd:COG1112 800 LDsdpSTPALKRLLEYLERA 819
|
|
| TIGR00376 |
TIGR00376 |
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of ... |
482-943 |
3.11e-55 |
|
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of this family have been characterized as binding certain single-stranded G-rich DNA sequences (GGGGT and GGGCT). A number of related proteins are characterized as helicases. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273041 [Multi-domain] Cd Length: 636 Bit Score: 203.12 E-value: 3.11e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 482 FQPrwFDRKLqaNEEQCRAVTHIVtgmSRPAPYLIFGPPGTGKTVTLVEAIKQVwtCFKDARILACAPSNSAADLLCQRL 561
Cdd:TIGR00376 151 FQF--FDPNL--NESQKEAVLFAL---SSKDLFLIHGPPGTGKTRTVVELIRQL--VKRGLRVLVTAPSNIAVDNLLERL 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 562 I----------------KDIAPRYIYRLIASSRSYQEVpADIRPCC-------------------NWDDQQ--------- 597
Cdd:TIGR00376 222 AlcdqkivrlghparllKSNKQHSLDYLIENHPKYQIV-ADIREKIdelieernkktkpspqkrrGLSDIKilrkalkkr 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 598 --------------------------SCYVYPNKEHLGRyRILITTLVTAGRLVSANFPPGYFSHVFIDECGQAVEPESL 651
Cdd:TIGR00376 301 eargieslkiasmaewietnksidrlLKLLPESEERIMN-EILAESDATNSMAGSEILNGQYFDVAVIDEASQAMEPSCL 379
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 652 IAIAglltamdqetnpNGGQLVLAGDPQQLGPVLRSPLAieHGLGTSLLERLMlhnPLYkrssggynPQFVTKLLWNYRS 731
Cdd:TIGR00376 380 IPLL------------KARKLILAGDHKQLPPTILSHDA--EELSLTLFERLI---KEY--------PERSRTLNVQYRM 434
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 732 HEAILRIPNELFYDSELKPCQTdeldVRNLycAWEELPKK-----------GFPIIF---HGVCGEDRREAKSPSFFNTA 797
Cdd:TIGR00376 435 NQKIMEFPSREFYNGKLTAHES----VANI--LLRDLPKVeateseddletGIPLLFidtSGCELFELKEADSTSKYNPG 508
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 798 EIEVLVHYLQKLLqsrgKRGCPtisPKEIGIISPYRKQVEKIRKAITsldpvlRKLPDIkllKVGSVEEFQGQERRVILI 877
Cdd:TIGR00376 509 EAELVSEIIQALV----KMGVP---ANDIGVITPYDAQVDLLRQLLE------HRHIDI---EVSSVDGFQGREKEVIII 572
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2728217431 878 STVRScseylqfDQTFKLGFLKNPKRLNVAITRAKALLIVVGNPAVLSKDHHWQRFLRYCKEEGGY 943
Cdd:TIGR00376 573 SFVRS-------NRKGEVGFLKDLRRLNVALTRARRKLIVIGDSRTLSNHKFYKRLIEWCKQHGEV 631
|
|
| DEXXQc_HELZ |
cd18077 |
DEXXQ-box helicase domain of HELZ; Helicase with zinc finger (HELZ) acts as a helicase that ... |
494-708 |
6.81e-35 |
|
DEXXQ-box helicase domain of HELZ; Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. HELZ is a member of the family I class of RNA helicases of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350835 [Multi-domain] Cd Length: 226 Bit Score: 132.99 E-value: 6.81e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 494 NEEQCRAVTHIVTGMSRPAP-YLIFGPPGTGKTVTLVEAIKQVWTCfKDARILACAPSNSAADLLcqrlIKDIAPRYIY- 571
Cdd:cd18077 3 NAKQKEAVLAITTPLSIQLPpVLLIGPFGTGKTFTLAQAVKHILQQ-PETRILICTHSNSAADLY----IKEYLHPYVEt 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 572 --------RLIASSRSYQEVPADIRPCCnWDDQQSCYVYPNKEHLGRYRILITTLVTAGRLVSANFPPGYFSHVFIDECG 643
Cdd:cd18077 78 gnprarplRVYYRNRWVKTVHPVVQKYC-LIDEHGTFRMPTREDVMRHRVVVVTLSTSQYLCQLDLEPGFFTHILLDEAA 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2728217431 644 QAVEPESLIAiaglLTAMDQETnpnggQLVLAGDPQQLGPVLRSPLAIEHGLGTSLLERLMLHNP 708
Cdd:cd18077 157 QAMECEAIMP----LALATKST-----RIVLAGDHMQLSPEVYSEFARERNLHISLLERLYEHYP 212
|
|
| DEXXQc_SMUBP2 |
cd18044 |
DEXXQ-box helicase domain of SMUBP2; SMUBP2 (also called immunoglobulin mu-binding protein 2, ... |
494-712 |
2.94e-31 |
|
DEXXQ-box helicase domain of SMUBP2; SMUBP2 (also called immunoglobulin mu-binding protein 2, or IGHMBP2) is a 5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction. It is a DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence (5'-GGGCT-3') related to the immunoglobulin mu chain switch region. The IGHMBP2 gene is responsible for Charcot-Marie-Tooth disease (CMT) type 2S and spinal muscular atrophy with respiratory distress type 1 (SMARD1). It is also thought to play a role in frontotemporal dementia (FTD) with amyotrophic lateral sclerosis (ALS) and major depressive disorder (MDD). SMUBP2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350802 [Multi-domain] Cd Length: 191 Bit Score: 121.18 E-value: 2.94e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 494 NEEQCRAVThivTGMSRPAPYLIFGPPGTGKTVTLVEAIKQvwTCFKDARILACAPSNSAADLLCQRLIKDIAPryIYRL 573
Cdd:cd18044 3 NDSQKEAVK---FALSQKDVALIHGPPGTGKTTTVVEIILQ--AVKRGEKVLACAPSNIAVDNLVERLVALKVK--VVRI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 574 IASSRSYQEVpadirpccnwddQQSCYvypnkEHLGRYRILITTLVTAGRLVSAnfPPGYFSHVFIDECGQAVEPESLIA 653
Cdd:cd18044 76 GHPARLLESV------------LDHSL-----DALVAAQVVLATNTGAGSRQLL--PNELFDVVVIDEAAQALEASCWIP 136
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 654 IAGlltamdqetnpnGGQLVLAGDPQQLGPVLRSPLAIEHGLGTSLLERLM-LHNPLYKR 712
Cdd:cd18044 137 LLK------------ARRCILAGDHKQLPPTILSDKAARGGLGVTLFERLVnLYGESVVR 184
|
|
| DEXXQc_UPF1 |
cd18039 |
DEXXQ-box helicase domain of UPF1; UPF1 (also called RNA Helicase And ATPase, Regulator Of ... |
494-707 |
5.69e-28 |
|
DEXXQ-box helicase domain of UPF1; UPF1 (also called RNA Helicase And ATPase, Regulator Of Nonsense Transcripts, or ATP-Dependent Helicase RENT1) is an RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. It is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. It is recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) located downstream from the termination codon through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Diseases associated with UPF1 include juvenile amyotrophic lateral sclerosis and epidermolysis bullosa, junctional, non-Herlitz type. UPF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350797 [Multi-domain] Cd Length: 234 Bit Score: 113.11 E-value: 5.69e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 494 NEEQCRAVTHIvtgMSRPAPyLIFGPPGTGKTVTLVEAIKQVWTCFKDaRILACAPSNSAADLLCQRlIKDIAPRYIyRL 573
Cdd:cd18039 3 NHSQVDAVKTA---LQRPLS-LIQGPPGTGKTVTSATIVYHLVKQGNG-PVLVCAPSNVAVDQLTEK-IHQTGLKVV-RL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 574 IASSRSYQEVPA-------DIRPCCNWDDQQ--SCYVYPNKEHL----GRYRILI---------------TTLVTAG--R 623
Cdd:cd18039 76 CAKSREAVESPVsflalhnQVRNLDSAEKLEllKLLKLETGELSsadeKRYRKLKrkaerellrnadvicCTCVGAGdpR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 624 LVSANFPpgyfsHVFIDECGQAVEPESLIAIaglltamdqetNPNGGQLVLAGDPQQLGPVLRSPLAIEHGLGTSLLERL 703
Cdd:cd18039 156 LSKMKFR-----TVLIDEATQATEPECLIPL-----------VHGAKQVILVGDHCQLGPVVMCKKAAKAGLSQSLFERL 219
|
....
gi 2728217431 704 MLHN 707
Cdd:cd18039 220 VQLG 223
|
|
| DEXXQc_HELZ2-N |
cd18076 |
N-terminal DEXXQ-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known ... |
494-705 |
3.84e-27 |
|
N-terminal DEXXQ-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known as PPAR-alpha-interacting complex protein 285 or PRIC285 and PPAR-gamma DBD-interacting protein 1 or PDIP1) acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB, and RXRA. It belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350834 [Multi-domain] Cd Length: 230 Bit Score: 110.75 E-value: 3.84e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 494 NEEQCRAVTHIV---TGMSRPAPYLIFGPPGTGKTVTLVEAIKQVwTCFKDARILACAPSNSAADLLcqrlIKDIAPRYI 570
Cdd:cd18076 3 NNKQQLAFNFIAgkpSEARFVPPLLIYGPFGTGKTFTLAMAALEV-IREPGTKVLICTHTNSAADIY----IREYFHPYV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 571 ---------YRLIASSRSY-QEVPADIRPCCNWDDQQsCYVYPNKEHLGRYRILITTLVTAGRLVSanfPPGYFSHVFID 640
Cdd:cd18076 78 dkghpearpLRIKATDRPNaITDPDTITYCCLTKDRQ-CFRLPTRDELDFHNIVITTTAMAFNLHV---LSGFFTHIFID 153
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2728217431 641 ECGQAVEPESLIAIAglltamdqeTNPNGGQLVLAGDPQQLGPVLRSpLAIEHGLGTSLLERLML 705
Cdd:cd18076 154 EAAQMLECEALIPLS---------YAGPKTRVVLAGDHMQMTPKLFS-VADYNRANHTLLNRLFH 208
|
|
| DEXXQc_SETX |
cd18042 |
DEXXQ-box helicase domain of SETX; The RNA/DNA helicase senataxin (SETX) plays a role in ... |
494-707 |
1.32e-25 |
|
DEXXQ-box helicase domain of SETX; The RNA/DNA helicase senataxin (SETX) plays a role in transcription, neurogenesis, and antiviral response. SEXT is an R-loop-associated protein that is thought to function as an RNA/DNA helicase. R-loops consist of RNA/DNA hybrids, formed during transcription when nascent RNA hybridizes to the DNA template strand, displacing the non-template DNA strand. Mutations in SETX are linked to two neurodegenerative disorders: ataxia with oculomotor apraxia type 2 (AOA2) and amyotrophic lateral sclerosis type 4 (ALS4). S. cerevisiae homolog splicing endonuclease 1 (Sen1) is an exclusively nuclear protein, important for nucleolar organization. S. cerevisiae Sen1 and its ortholog, the Schizosaccharomyces pombe Sen1, share conserved domains and belong to the family I class of helicases. Both proteins translocate 5' to 3' and unwind both DNA and RNA duplexes and also RNA/DNA hybrids in vitro. SETX is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438712 [Multi-domain] Cd Length: 218 Bit Score: 105.76 E-value: 1.32e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 494 NEEQCRAVTHIVTGMSRPApyLIFGPPGTGKTVTLV---------------------EAIKQVWTCFKDA--RILACAPS 550
Cdd:cd18042 2 NESQLEAIASALQNSPGIT--LIQGPPGTGKTKTIVgilsvllagkyrkyyekvkkkLRKLQRNLNNKKKknRILVCAPS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 551 NSAADLLCQRLIKDIAP-----RYIYRLIASSRSyqevpaDIRpccnwddqqscyvypnKEHLGRYRILITTLVTAGRLV 625
Cdd:cd18042 80 NAAVDEIVLRLLSEGFLdgdgrSYKPNVVRVGRQ------ELR----------------ASILNEADIVCTTLSSSGSDL 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 626 SANFPPGyFSHVFIDECGQAVEPESLIAIAglltamdqetnPNGGQLVLAGDPQQLGPVLRSPLAIEHGLGTSLLERLML 705
Cdd:cd18042 138 LESLPRG-FDTVIIDEAAQAVELSTLIPLR-----------LGCKRLILVGDPKQLPATVFSKVAQKLGYDRSLFERLQL 205
|
..
gi 2728217431 706 HN 707
Cdd:cd18042 206 AG 207
|
|
| AAA_11 |
pfam13086 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
497-688 |
2.01e-19 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 404072 [Multi-domain] Cd Length: 248 Bit Score: 88.94 E-value: 2.01e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 497 QCRAVTHIVtgmSRPAPYLIFGPPGTGKTVTLVEAIKQ-----VWTCFKDARILACAPSNSAADLLCQRLIKDIA----- 566
Cdd:pfam13086 2 QREAIRSAL---SSSHFTLIQGPPGTGKTTTIVELIRQllsypATSAAAGPRILVCAPSNAAVDNILERLLRKGQkygpk 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 567 -------------------PRYIYRLIASSRSYQ--------------EVPADIRPCCNWDDQQSCYVYPNKEH------ 607
Cdd:pfam13086 79 ivrighpaaiseavlpvslDYLVESKLNNEEDAQivkdiskeleklakALRAFEKEIIVEKLLKSRNKDKSKLEqerrkl 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 608 ----------------------LGRYRILITTLVTAGRLVSANFPPgyFSHVFIDECGQAVEPESLIAiagLLTAmdqet 665
Cdd:pfam13086 159 rserkelrkelrrreqslereiLDEAQIVCSTLSGAGSRLLSSLAN--FDVVIIDEAAQALEPSTLIP---LLRG----- 228
|
250 260
....*....|....*....|...
gi 2728217431 666 npnGGQLVLAGDPQQLGPVLRSP 688
Cdd:pfam13086 229 ---PKKVVLVGDPKQLPPTVISK 248
|
|
| DEXXQc_DNA2 |
cd18041 |
DEXXQ-box helicase domain of DNA2; DNA2 (DNA Replication Helicase/Nuclease 2) possesses ... |
494-708 |
1.27e-18 |
|
DEXXQ-box helicase domain of DNA2; DNA2 (DNA Replication Helicase/Nuclease 2) possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5-3 helicase, and endonuclease activities, and is involved in DNA replication and DNA repair in the nucleus and mitochondrion. It is involved in Okazaki fragment processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. It is also involved in 5-end resection of DNA during double-strand break (DSB) repair; it is recruited by BLM and mediates the cleavage of 5-ssDNA, while the 3-ssDNA cleavage is prevented by the presence of RPA. DNA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350799 [Multi-domain] Cd Length: 203 Bit Score: 85.37 E-value: 1.27e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 494 NEEQCRAVTHIVTGMSrpapY-LIFGPPGTGKTVTLVEAIKQVWTCFKdaRILACAPSNSAADLLCQRLIKDIAPryIYR 572
Cdd:cd18041 3 NKDQRQAIKKVLNAKD----YaLILGMPGTGKTTTIAALVRILVALGK--SVLLTSYTHSAVDNILLKLKKFGVN--FLR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 573 LiasSRSYQEVPaDIRPCCNWDDQQSCyvyPNKEHLgrYRILITTLVTAGRLVSAN---FPPGYFSHVFIDECGQAVEPE 649
Cdd:cd18041 75 L---GRLKKIHP-DVQEFTLEAILKSC---KSVEEL--ESKYESVSVVATTCLGINhpiFRRRTFDYCIVDEASQITLPI 145
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 2728217431 650 SLIAIAglltamdqetnpNGGQLVLAGDPQQLGPVLRSPLAIEHGLGTSLLERLMLHNP 708
Cdd:cd18041 146 CLGPLR------------LAKKFVLVGDHYQLPPLVKSREARELGMDESLFKRLSEAHP 192
|
|
| DEXXQc_Upf1-like |
cd17934 |
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, ... |
515-730 |
4.11e-17 |
|
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), coronavirus Nsp13, and similar proteins. They belong to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438708 [Multi-domain] Cd Length: 121 Bit Score: 78.43 E-value: 4.11e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 515 LIFGPPGTGKTVTLVEAIKQVWTCFKDARILACAPSNSAADLLcqrlikdiapryiyrliassrsyqevpadirpccnwd 594
Cdd:cd17934 3 LIQGPPGTGKTTTIAAIVLQLLKGLRGKRVLVTAQSNVAVDNV------------------------------------- 45
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 595 dqqscyvypnkehlgryrilittlvtagrlvsanfppgyfSHVFIDECGQAVEPESLIAIAGlltamdqetnpnGGQLVL 674
Cdd:cd17934 46 ----------------------------------------DVVIIDEASQITEPELLIALIR------------AKKVVL 73
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 2728217431 675 AGDPQQLGPVLRS--PLAIEHGLGTSLLERLMLHNPlykrssgGYNPQFvtkLLWNYR 730
Cdd:cd17934 74 VGDPKQLPPVVQEdhAALLGLSFILSLLLLFRLLLP-------GSPKVM---LDTQYR 121
|
|
| DEXXc_HELZ2-C |
cd18040 |
C-terminal DEXX-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known ... |
494-703 |
4.73e-14 |
|
C-terminal DEXX-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known as PPAR-alpha-interacting complex protein 285 or PRIC285 and PPAR-gamma DBD-interacting protein 1 or PDIP1) acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA. It belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350798 [Multi-domain] Cd Length: 271 Bit Score: 73.33 E-value: 4.73e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 494 NEEQCRAVThivTGMSRPApYLIFGPPGTGKTVT-------LVEAIKQVWTCFKDAR----ILACAPSNSAADLLCQRL- 561
Cdd:cd18040 3 NPSQNHAVR---TALTKPF-TLIQGPPGTGKTVTgvhiaywFAKQNREIQSVSGEGDggpcVLYCGPSNKSVDVVAELLl 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 562 -IKDIAPRYIYRLIA----------SSRSYQEVPADIRPCCNWDD---------------QQSCYV--------YP-NKE 606
Cdd:cd18040 79 kVPGLKILRVYSEQIetteypipnePRHPNKKSERESKPNSELSSitlhhrirqpsnphsQQIKAFearfertqEKiTEE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 607 HLGRYRILITT------------LVTAGRLVSANF-PPGYFSHVFIDECGQAVEPESLIAIAglltamdqeTNPNGGQLV 673
Cdd:cd18040 159 DIKTYKILIWEarfeeletvdviLCTCSEAASQKMrTHANVKQCIVDECGMCTEPESLIPIV---------SAPRAEQVV 229
|
250 260 270
....*....|....*....|....*....|
gi 2728217431 674 LAGDPQQLGPVLRSPLAIEHGLGTSLLERL 703
Cdd:cd18040 230 LIGDHKQLRPVVQNKEAQKLGLGRSLFERY 259
|
|
| RecD |
COG0507 |
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ... |
485-684 |
8.44e-10 |
|
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440273 [Multi-domain] Cd Length: 514 Bit Score: 62.30 E-value: 8.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 485 RWFDRK-LQANEEQCRAVTHIVTGmSRPApyLIFGPPGTGKTvTLVEAIKQVWTcFKDARILACAPSNSAAdllcQRLIK 563
Cdd:COG0507 116 ALEPRAgITLSDEQREAVALALTT-RRVS--VLTGGAGTGKT-TTLRALLAALE-ALGLRVALAAPTGKAA----KRLSE 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 564 DIAPRY--IYRLIAssrsyqevpadirpccnWDDQQSCYVYPNKEHLGRYRILIttlvtagrlvsanfppgyfshvfIDE 641
Cdd:COG0507 187 STGIEArtIHRLLG-----------------LRPDSGRFRHNRDNPLTPADLLV-----------------------VDE 226
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 2728217431 642 CgqavepeSLIAIAgLLTAMDQETNPNGGQLVLAGDPQQLGPV 684
Cdd:COG0507 227 A-------SMVDTR-LMAALLEALPRAGARLILVGDPDQLPSV 261
|
|
| EEXXQc_AQR |
cd17935 |
EEXXQ-box helicase domain of AQR; Aquarius (AQR) is a multifunctional RNA helicase that binds ... |
504-703 |
9.74e-09 |
|
EEXXQ-box helicase domain of AQR; Aquarius (AQR) is a multifunctional RNA helicase that binds precursor-mRNA introns at a defined position and is part of a pentameric intron-binding complex (IBC). It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350693 [Multi-domain] Cd Length: 207 Bit Score: 56.67 E-value: 9.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 504 IVTGMsRPAPYLIFGPPGTGKTVTLVEAIKQVWTCFKDARILACAPSNSAADLLCQRLIK-DIAPRYIYRLIASSRsyqe 582
Cdd:cd17935 14 IRSGM-QPGLTMVVGPPGTGKTDVAVQIISNLYHNFPNQRTLIVTHSNQALNQLFEKIMAlDIDERHLLRLGHGAK---- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 583 vpadIRPCcnwddqqSCyvypnkEHLGRYRilittlvtaGRLVSANFPpgyFSHVFIDECGQAVEPESLIAiaglLTAMD 662
Cdd:cd17935 89 ----IIAM-------TC------THAALKR---------GELVELGFK---YDNILMEEAAQILEIETFIP----LLLQN 135
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 2728217431 663 QETNPNG-GQLVLAGDPQQLGPVLRSP-LAIEHGLGTSLLERL 703
Cdd:cd17935 136 PEDGPNRlKRLIMIGDHHQLPPVIKNMaFQKYSNMEQSLFTRL 178
|
|
| DEXSc_RecD-like |
cd17933 |
DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1. ... |
496-684 |
5.31e-08 |
|
DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1.11.5, Exonuclease V) complex. It is the alpha chain of the complex and functions as a 3'-5' helicase. The RecBCD enzyme is both a helicase that unwinds, or separates the strands of DNA, and a nuclease that makes single-stranded nicks in DNA. RecD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350691 [Multi-domain] Cd Length: 155 Bit Score: 52.94 E-value: 5.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 496 EQCRAVTHIVT-GMSrpapyLIFGPPGTGKTVTLVEAIKQVWTcfKDARILACAPSNSAAdllcQRL--IKDIAPRYIYR 572
Cdd:cd17933 1 EQKAAVRLVLRnRVS-----VLTGGAGTGKTTTLKALLAALEA--EGKRVVLAAPTGKAA----KRLseSTGIEASTIHR 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 573 LIassrsyqevpadirpccnWDDQQSCYVYPNKEHLGRYRILIttlvtagrlvsanfppgyfshvfIDECgqavepeSLI 652
Cdd:cd17933 70 LL------------------GINPGGGGFYYNEENPLDADLLI-----------------------VDEA-------SMV 101
|
170 180 190
....*....|....*....|....*....|....*
gi 2728217431 653 AI---AGLLTAMdqetnPNGGQLVLAGDPQQLGPV 684
Cdd:cd17933 102 DTrlmAALLSAI-----PAGARLILVGDPDQLPSV 131
|
|
| AAA_30 |
pfam13604 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
492-684 |
1.88e-07 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. There is a Walker A and Walker B.
Pssm-ID: 433343 [Multi-domain] Cd Length: 191 Bit Score: 52.18 E-value: 1.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 492 QANEEQCRAVTHIVTgmSRPAPYLIFGPPGTGKTvTLVEAIKQVWTcfkDA--RILACAPSNSAADLLCQRLikDIAPRY 569
Cdd:pfam13604 1 TLNAEQAAAVRALLT--SGDRVAVLVGPAGTGKT-TALKALREAWE---AAgyRVIGLAPTGRAAKVLGEEL--GIPADT 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 570 IYRLIassrsyqevpadirpccnwddqqscyvypnkehlgrYRILITTLVTAGRLvsanfppgyfshVFIDECGQAvepe 649
Cdd:pfam13604 73 IAKLL------------------------------------HRLGGRAGLDPGTL------------LIVDEAGMV---- 100
|
170 180 190
....*....|....*....|....*....|....*
gi 2728217431 650 SLIAIAGLLTAMDQEtnpnGGQLVLAGDPQQLGPV 684
Cdd:pfam13604 101 GTRQMARLLKLAEDA----GARVILVGDPRQLPSV 131
|
|
| SF1_C |
cd18786 |
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family ... |
825-919 |
2.61e-07 |
|
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Similar to SF2 helicases, they do not form toroidal, predominantly hexameric structures like SF3-6. SF1 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350173 [Multi-domain] Cd Length: 89 Bit Score: 49.36 E-value: 2.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 825 EIGIISPYRKQVEKIRKAITSLDpvlRKLPDIKLLKVGSVEEFQGQERRVILISTVRSCSEylqfdqtfklgflkNPKRL 904
Cdd:cd18786 12 KGVVLTPYHRDRAYLNQYLQGLS---LDEFDLQLVGAITIDSSQGLTFDVVTLYLPTANSL--------------TPRRL 74
|
90
....*....|....*
gi 2728217431 905 NVAITRAKALLIVVG 919
Cdd:cd18786 75 YVALTRARKRLVIYD 89
|
|
| EEXXEc_NFX1 |
cd17936 |
EEXXE-box helicase domain of NFX1; Human NFX1 protein was identified as a protein that ... |
494-703 |
2.83e-07 |
|
EEXXE-box helicase domain of NFX1; Human NFX1 protein was identified as a protein that represses class II MHC (major histocompatibility complex) gene expression. NFX1 binds a conserved cis-acting element, termed the X-box, in promoters of human class II MHC genes. The Cys-rich region contains several NFX1-type zinc finger domains. Frequently, a R3H domain is present in the C-terminus, and a RING finger domain and a PAM2 motif are present in the N-terminus. The lack of R3H and PAM2 motifs in the plant proteins indicates functional differences. Plant NFX1-like proteins are proposed to modulate growth and survival by coordinating reactive oxygen species, salicylic acid, further biotic stress and abscisic acid responses. A common feature of all members may be E3 ubiquitin ligase, due to the presence of a RING finger domain, as well as DNA binding. NFX1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350694 [Multi-domain] Cd Length: 178 Bit Score: 51.39 E-value: 2.83e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 494 NEEQCRAVTHIVTgmSRPApyLIFGPPGTGKT---VTLVEAIKQVWTCFKDARILACAPSNSAADLLCQRLIKDIAP--- 567
Cdd:cd17936 3 DPSQLEALKHALT--SELA--LIQGPPGTGKTflgVKLVRALLQNQDLSITGPILVVCYTNHALDQFLEGLLDFGPTkiv 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 568 RYIYRLIASSRSYqevpadirpccnwddqqscyvypnkehLGRYRILITTLvtagrlvsanfppgYFSHVFIDECGQAVE 647
Cdd:cd17936 79 RLGARVIGMTTTG---------------------------AAKYRELLQAL--------------GPKVVIVEEAAEVLE 117
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 2728217431 648 pesliaiAGLLTAMDQETNpnggQLVLAGDPQQLGPVLRSPLAIEHG--LGTSLLERL 703
Cdd:cd17936 118 -------AHILAALTPSTE----HLILIGDHKQLRPKVNVYELTAKKynLDVSLFERL 164
|
|
| DExxQc_SF1-N |
cd17914 |
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members ... |
515-605 |
4.44e-06 |
|
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Like SF2, they do not form toroidal, predominantly hexameric structures like SF3-6. Their helicase core is surrounded by C and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains or domains engaged in protein-protein interactions. SF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438706 [Multi-domain] Cd Length: 121 Bit Score: 46.71 E-value: 4.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 515 LIFGPPGTGKTVTLVEAIKQVWT--CFKDARILACAPSNSAADLLCQRLI---KDIAPRYIYRLIASSRSYQEVpadirp 589
Cdd:cd17914 3 LIQGPPGTGKTRVLVKIVAALMQnkNGEPGRILLVTPTNKAAAQLDNILVdeaAQILEPETSRLIDLALDQGRV------ 76
|
90
....*....|....*.
gi 2728217431 590 CCNWDDQQSCYVYPNK 605
Cdd:cd17914 77 ILVGDHDQLGPVWRGA 92
|
|
| AAA_19 |
pfam13245 |
AAA domain; |
504-684 |
9.45e-05 |
|
AAA domain;
Pssm-ID: 433059 [Multi-domain] Cd Length: 136 Bit Score: 43.36 E-value: 9.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 504 IVTGMSRPAPYLIFGPPGTGKTVTLVEAIKQ-VWTCFKDARILACAPSNSAADLLCQRLIKDIapRYIYRLIassrsyqe 582
Cdd:pfam13245 4 AVRTALPSKVVLLTGGPGTGKTTTIRHIVALlVALGGVSFPILLAAPTGRAAKRLSERTGLPA--STIHRLL-------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 583 vpadirpccNWDDqqscyvypnkehlgryrilittLVTAGRLVS-ANFPPGYfsHVFIDECgQAVepeSLIAIAGLLTAM 661
Cdd:pfam13245 74 ---------GFDD----------------------LEAGGFLRDeEEPLDGD--LLIVDEF-SMV---DLPLAYRLLKAL 116
|
170 180
....*....|....*....|...
gi 2728217431 662 dqetnPNGGQLVLAGDPQQLGPV 684
Cdd:pfam13245 117 -----PDGAQLLLVGDPDQLPSV 134
|
|
| CoV_Nsp13-helicase |
cd21718 |
helicase domain of coronavirus non-structural protein 13; This model represents the helicase ... |
516-918 |
9.51e-05 |
|
helicase domain of coronavirus non-structural protein 13; This model represents the helicase domain of non-structural protein 13 (Nsp13) from alpha-, beta-, gamma-, and deltacoronavirus, including pathogenic human viruses such as Severe acute respiratory syndrome coronavirus (SARS-CoV), SARS-CoV2 (also called 2019 novel CoV or 2019-nCoV), and Middle East respiratory syndrome-related (MERS) CoV. Helicases catalyze NTP-dependent unwinding of nucleic acid duplexes into single strands and are classified based on the arrangement of conserved motifs into six superfamilies. CoV Nsp13 is a member of the helicase superfamily 1 (SF1); SF1 and SF2 helicases do not form toroidal structures, while SF3-6 helicases do. Nsp13 is a component of the viral RNA synthesis replication and transcription complex (RTC). It is a multidomain protein containing a Cys/His rich zinc-binding domain (CH/ZBD), a stalk domain, a 1B domain involved in nucleic acid substrate binding, and a SF1 helicase core.
Pssm-ID: 409652 [Multi-domain] Cd Length: 341 Bit Score: 45.60 E-value: 9.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 516 IFGPPGTGKTVTLVEAIKQvwtcFKDARILACAPSNSAADLLCQRLIKDIAPRYIYRLiassrsyqeVPADIRPCCnWDD 595
Cdd:cd21718 30 VQGPPGTGKSHFAIGLALY----YPGARIVYTACSHAAVDALCEKASKWLPNDKCSRI---------VPQRARVEC-FDG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 596 qqscyvYPNKEHLGRYrilITTLVTAGRLVSANFppgyfshVFIDECGQAVEPEsliaiaglLTAMDQETNPNggQLVLA 675
Cdd:cd21718 96 ------FKVNNTNAQY---IFSTINALPECSADI-------VVVDEVSMCTNYD--------LSVVNARLKYK--HIVYV 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 676 GDPQQLgPVLRSplaiehglgtsLLERLMLhNPLYkrssggYNpqFVTKLLWN----------YRSHEAILRIPNELFYD 745
Cdd:cd21718 150 GDPAQL-PAPRT-----------LLTEGSL-EPKD------YN--VVTRLMVGsgpdvflskcYRCPKEIVDTVSKLVYD 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 746 SELKPCQTDEldvrnlycaweelpKKGFPIIFHGVCGEDrreakSPSFFNTAEIEVLVHYLqkllqSRGKRGcptispKE 825
Cdd:cd21718 209 NKLKAIKPKS--------------RQCFKTFGKGDVRHD-----NGSAINRPQLEFVKRFL-----DRNPRW------RK 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 826 IGIISPYRKQVEKIRKAITsldpvlrklpdiklLKVGSVEEFQGQErrvilistvrscSEYLQFDQTFKLGFLKNPKRLN 905
Cdd:cd21718 259 AVFISPYNAMNNRASRLLG--------------LSTQTVDSSQGSE------------YDYVIFCQTTDTAHALNINRFN 312
|
410
....*....|...
gi 2728217431 906 VAITRAKALLIVV 918
Cdd:cd21718 313 VAITRAKHGILVI 325
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
497-642 |
2.93e-04 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 43.25 E-value: 2.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 497 QCRAVTHIVTGMSRpapYLIFGPPGTGKTVTLVEAIKQVWTCFKDARILACAPSNSAADLLCQRLIK---DIAPRYIYRL 573
Cdd:smart00487 13 QKEAIEALLSGLRD---VILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKlgpSLGLKVVGLY 89
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2728217431 574 IASSRSYQEvpadirpccnwddqqscyvypNKEHLGRYRILITTLVTAGRLVSAN-FPPGYFSHVFIDEC 642
Cdd:smart00487 90 GGDSKREQL---------------------RKLESGKTDILVTTPGRLLDLLENDkLSLSNVDLVILDEA 138
|
|
| UvrD |
COG0210 |
Superfamily I DNA or RNA helicase [Replication, recombination and repair]; |
494-554 |
6.51e-04 |
|
Superfamily I DNA or RNA helicase [Replication, recombination and repair];
Pssm-ID: 439980 [Multi-domain] Cd Length: 721 Bit Score: 43.77 E-value: 6.51e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2728217431 494 NEEQCRAVTHIvtgmsrPAPYLIFGPPGTGKTVTLVEAI------KQVWtcfkDARILACAPSNSAA 554
Cdd:COG0210 8 NPEQRAAVEHP------EGPLLVLAGAGSGKTRVLTHRIayliaeGGVD----PEQILAVTFTNKAA 64
|
|
| |
