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Conserved domains on  [gi|544472714|ref|XP_005572194|]
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sialate:O-sulfotransferase 2 isoform X1 [Macaca fascicularis]

Protein Classification

WSC domain-containing protein; sulfotransferase family protein( domain architecture ID 10646090)

WSC (cell wall integrity and stress response component) domain-containing protein may bind carbohydrates; the domain contains up to eight conserved cysteine residues that may be involved in disulfide bridges| sulfotransferase family protein may catalyze the transfer of sulfate from a donor such as 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to an acceptor substrate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WSC smart00321
present in yeast cell wall integrity and stress response component proteins; Domain present in ...
 127-219 3.29e-35

present in yeast cell wall integrity and stress response component proteins; Domain present in WSC proteins, polycystin and fungal exoglucanase


:

Pssm-ID: 214616 [Multi-domain]  Cd Length: 95  Bit Score: 127.59  E-value: 3.29e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544472714   127 RAKYIGCYLDDtQSRALRGVSFFDYKKMTIFRCQDNCAERGYLYAGLEFGAECYCGHKIQATNVS---EAECDMECKGER 203
Cdd:smart00321   1 GATYVGCYSDN-SSRTLAAVSSYAYHNMSVEACSNFCFSAGYALAALENGNECYCGDSLPSTSVSasdSSQCSTTCSGYP 79

                           90
                   ....*....|....*.
gi 544472714   204 GSVCGGANRLSVYRLQ 219
Cdd:smart00321  80 AEVCGGPNRLSVYVLA 95
WSC smart00321
present in yeast cell wall integrity and stress response component proteins; Domain present in ...
 230-324 9.73e-32

present in yeast cell wall integrity and stress response component proteins; Domain present in WSC proteins, polycystin and fungal exoglucanase


:

Pssm-ID: 214616 [Multi-domain]  Cd Length: 95  Bit Score: 117.96  E-value: 9.73e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544472714   230 SAVFRGCFRRPDNLSLALPVTAAMLNMSVDKCVDFCTEKEYPLAAL-AGTACHCGFPTTRFPLHdREDEQLCAQKCSAEE 308
Cdd:smart00321   1 GATYVGCYSDNSSRTLAAVSSYAYHNMSVEACSNFCFSAGYALAALeNGNECYCGDSLPSTSVS-ASDSSQCSTTCSGYP 79

                           90
                   ....*....|....*.
gi 544472714   309 FESCGTPSYFIVYQTQ 324
Cdd:smart00321  80 AEVCGGPNRLSVYVLA 95
Sulfotransfer_1 super family cl21551
Sulfotransferase domain;
415-507 1.00e-04

Sulfotransferase domain;


The actual alignment was detected with superfamily member pfam00685:

Pssm-ID: 473908 [Multi-domain]  Cd Length: 253  Bit Score: 44.26  E-value: 1.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544472714  415 ILLIRNPYKALMAEFnrkyggHIGFAAHAHWKGKEWPEFVR-------NYAPWWaTHTLDWLKFGKK--VLVVHFEDLKQ 485
Cdd:pfam00685  96 IYLVRNPKDVAVSYY------HFFRMAKLLKAPGTPFEFVEdflngkvNCGSYF-DHVKGWWKLRPPgnILFLRYEDLKK 168

                          90       100
                  ....*....|....*....|..
gi 544472714  486 DLFIQLGRMVNLLGVAVREDRL 507
Cdd:pfam00685 169 DPRGEIKKIAEFLGIPLTEEEL 190
 
Name Accession Description Interval E-value
WSC smart00321
present in yeast cell wall integrity and stress response component proteins; Domain present in ...
 127-219 3.29e-35

present in yeast cell wall integrity and stress response component proteins; Domain present in WSC proteins, polycystin and fungal exoglucanase


Pssm-ID: 214616 [Multi-domain]  Cd Length: 95  Bit Score: 127.59  E-value: 3.29e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544472714   127 RAKYIGCYLDDtQSRALRGVSFFDYKKMTIFRCQDNCAERGYLYAGLEFGAECYCGHKIQATNVS---EAECDMECKGER 203
Cdd:smart00321   1 GATYVGCYSDN-SSRTLAAVSSYAYHNMSVEACSNFCFSAGYALAALENGNECYCGDSLPSTSVSasdSSQCSTTCSGYP 79

                           90
                   ....*....|....*.
gi 544472714   204 GSVCGGANRLSVYRLQ 219
Cdd:smart00321  80 AEVCGGPNRLSVYVLA 95
WSC smart00321
present in yeast cell wall integrity and stress response component proteins; Domain present in ...
 230-324 9.73e-32

present in yeast cell wall integrity and stress response component proteins; Domain present in WSC proteins, polycystin and fungal exoglucanase


Pssm-ID: 214616 [Multi-domain]  Cd Length: 95  Bit Score: 117.96  E-value: 9.73e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544472714   230 SAVFRGCFRRPDNLSLALPVTAAMLNMSVDKCVDFCTEKEYPLAAL-AGTACHCGFPTTRFPLHdREDEQLCAQKCSAEE 308
Cdd:smart00321   1 GATYVGCYSDNSSRTLAAVSSYAYHNMSVEACSNFCFSAGYALAALeNGNECYCGDSLPSTSVS-ASDSSQCSTTCSGYP 79

                           90
                   ....*....|....*.
gi 544472714   309 FESCGTPSYFIVYQTQ 324
Cdd:smart00321  80 AEVCGGPNRLSVYVLA 95
WSC pfam01822
WSC domain; This domain is involved in carbohydrate binding.
 130-209 5.71e-25

WSC domain; This domain is involved in carbohydrate binding.


Pssm-ID: 460348  Cd Length: 82  Bit Score: 98.69  E-value: 5.71e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544472714  130 YIGCYLDDTQSRALRGVSFFDYKKMTIFRCQDNCAERGYLYAGLEFGAECYCGHKIQATNV--SEAECDMECKGERGSVC 207
Cdd:pfam01822   1 YLGCYSDGTGGRRLLLGSSGDYDDMTPEKCIAFCSAAGYTYAGLEYGGECYCGNSLPSGSAlaDSSDCNTPCPGDSSQTC 80


                  ..
gi 544472714  208 GG 209
Cdd:pfam01822  81 GG 82
WSC pfam01822
WSC domain; This domain is involved in carbohydrate binding.
 233-313 7.80e-16

WSC domain; This domain is involved in carbohydrate binding.


Pssm-ID: 460348  Cd Length: 82  Bit Score: 72.49  E-value: 7.80e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544472714  233 FRGCFR-RPDNLSLALPVTAAMLNMSVDKCVDFCTEKEYPLAAL-AGTACHCGFPTTRFPLHDreDEQLCAQKCSAEEFE 310
Cdd:pfam01822   1 YLGCYSdGTGGRRLLLGSSGDYDDMTPEKCIAFCSAAGYTYAGLeYGGECYCGNSLPSGSALA--DSSDCNTPCPGDSSQ 78


                  ...
gi 544472714  311 SCG 313
Cdd:pfam01822  79 TCG 81
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
415-507 1.00e-04

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 44.26  E-value: 1.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544472714  415 ILLIRNPYKALMAEFnrkyggHIGFAAHAHWKGKEWPEFVR-------NYAPWWaTHTLDWLKFGKK--VLVVHFEDLKQ 485
Cdd:pfam00685  96 IYLVRNPKDVAVSYY------HFFRMAKLLKAPGTPFEFVEdflngkvNCGSYF-DHVKGWWKLRPPgnILFLRYEDLKK 168

                          90       100
                  ....*....|....*....|..
gi 544472714  486 DLFIQLGRMVNLLGVAVREDRL 507
Cdd:pfam00685 169 DPRGEIKKIAEFLGIPLTEEEL 190
 
Name Accession Description Interval E-value
WSC smart00321
present in yeast cell wall integrity and stress response component proteins; Domain present in ...
 127-219 3.29e-35

present in yeast cell wall integrity and stress response component proteins; Domain present in WSC proteins, polycystin and fungal exoglucanase


Pssm-ID: 214616 [Multi-domain]  Cd Length: 95  Bit Score: 127.59  E-value: 3.29e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544472714   127 RAKYIGCYLDDtQSRALRGVSFFDYKKMTIFRCQDNCAERGYLYAGLEFGAECYCGHKIQATNVS---EAECDMECKGER 203
Cdd:smart00321   1 GATYVGCYSDN-SSRTLAAVSSYAYHNMSVEACSNFCFSAGYALAALENGNECYCGDSLPSTSVSasdSSQCSTTCSGYP 79

                           90
                   ....*....|....*.
gi 544472714   204 GSVCGGANRLSVYRLQ 219
Cdd:smart00321  80 AEVCGGPNRLSVYVLA 95
WSC smart00321
present in yeast cell wall integrity and stress response component proteins; Domain present in ...
 230-324 9.73e-32

present in yeast cell wall integrity and stress response component proteins; Domain present in WSC proteins, polycystin and fungal exoglucanase


Pssm-ID: 214616 [Multi-domain]  Cd Length: 95  Bit Score: 117.96  E-value: 9.73e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544472714   230 SAVFRGCFRRPDNLSLALPVTAAMLNMSVDKCVDFCTEKEYPLAAL-AGTACHCGFPTTRFPLHdREDEQLCAQKCSAEE 308
Cdd:smart00321   1 GATYVGCYSDNSSRTLAAVSSYAYHNMSVEACSNFCFSAGYALAALeNGNECYCGDSLPSTSVS-ASDSSQCSTTCSGYP 79

                           90
                   ....*....|....*.
gi 544472714   309 FESCGTPSYFIVYQTQ 324
Cdd:smart00321  80 AEVCGGPNRLSVYVLA 95
WSC pfam01822
WSC domain; This domain is involved in carbohydrate binding.
 130-209 5.71e-25

WSC domain; This domain is involved in carbohydrate binding.


Pssm-ID: 460348  Cd Length: 82  Bit Score: 98.69  E-value: 5.71e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544472714  130 YIGCYLDDTQSRALRGVSFFDYKKMTIFRCQDNCAERGYLYAGLEFGAECYCGHKIQATNV--SEAECDMECKGERGSVC 207
Cdd:pfam01822   1 YLGCYSDGTGGRRLLLGSSGDYDDMTPEKCIAFCSAAGYTYAGLEYGGECYCGNSLPSGSAlaDSSDCNTPCPGDSSQTC 80


                  ..
gi 544472714  208 GG 209
Cdd:pfam01822  81 GG 82
WSC pfam01822
WSC domain; This domain is involved in carbohydrate binding.
 233-313 7.80e-16

WSC domain; This domain is involved in carbohydrate binding.


Pssm-ID: 460348  Cd Length: 82  Bit Score: 72.49  E-value: 7.80e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544472714  233 FRGCFR-RPDNLSLALPVTAAMLNMSVDKCVDFCTEKEYPLAAL-AGTACHCGFPTTRFPLHDreDEQLCAQKCSAEEFE 310
Cdd:pfam01822   1 YLGCYSdGTGGRRLLLGSSGDYDDMTPEKCIAFCSAAGYTYAGLeYGGECYCGNSLPSGSALA--DSSDCNTPCPGDSSQ 78


                  ...
gi 544472714  311 SCG 313
Cdd:pfam01822  79 TCG 81
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
415-507 1.00e-04

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 44.26  E-value: 1.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544472714  415 ILLIRNPYKALMAEFnrkyggHIGFAAHAHWKGKEWPEFVR-------NYAPWWaTHTLDWLKFGKK--VLVVHFEDLKQ 485
Cdd:pfam00685  96 IYLVRNPKDVAVSYY------HFFRMAKLLKAPGTPFEFVEdflngkvNCGSYF-DHVKGWWKLRPPgnILFLRYEDLKK 168

                          90       100
                  ....*....|....*....|..
gi 544472714  486 DLFIQLGRMVNLLGVAVREDRL 507
Cdd:pfam00685 169 DPRGEIKKIAEFLGIPLTEEEL 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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