mediator of RNA polymerase II transcription subunit 25 isoform X4 [Rattus norvegicus]
Med25_VWA and Med25 domain-containing protein( domain architecture ID 12109167)
protein containing domains Med25_VWA, Med25_SD1, Med25, and Med25_NR-box
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
Med25_VWA | pfam11265 | Mediator complex subunit 25 von Willebrand factor type A; The overall function of the ... |
73-287 | 5.55e-119 | ||||
Mediator complex subunit 25 von Willebrand factor type A; The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain which is this one, an SD2 domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This VWA or von Willebrand factor type A domain when bound to RAR and the histone acetyltransferase CBP is responsible for recruiting Med1 to the rest of the Mediator complex. : Pssm-ID: 463253 Cd Length: 213 Bit Score: 357.76 E-value: 5.55e-119
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Med25 | pfam11232 | Mediator complex subunit 25 PTOV activation and synapsin 2; Mediator is a large complex of up ... |
457-606 | 2.32e-79 | ||||
Mediator complex subunit 25 PTOV activation and synapsin 2; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species. It is arranged into four different sections, a core, a head, a tail and a kinase-active part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This family is the combined PTOV and SD2 domains. the PTOV domain being the domain through which Med25 co-operates with the histone acetyltransferase CBP, but the function of the SD2 domain is unclear. : Pssm-ID: 463243 Cd Length: 154 Bit Score: 251.88 E-value: 2.32e-79
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Med25_SD1 super family | cl25802 | Mediator complex subunit 25 synapsin 1; The overall function of the full-length Med25 is ... |
289-444 | 9.23e-43 | ||||
Mediator complex subunit 25 synapsin 1; The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA, domain, this SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This The function of the SD domains is unclear. The actual alignment was detected with superfamily member pfam11235: Pssm-ID: 463244 [Multi-domain] Cd Length: 157 Bit Score: 152.63 E-value: 9.23e-43
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Med25_NR-box | pfam11244 | Mediator complex subunit 25 C-terminal NR box-containing; The overall function of the ... |
718-806 | 1.78e-34 | ||||
Mediator complex subunit 25 C-terminal NR box-containing; The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA, domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and this C-terminal NR box-containing domain (646-650) from C69-747. The NR box of MED25 is critical for its recruitment to the promoter, probably through an interaction with pre bound RAR. : Pssm-ID: 463246 [Multi-domain] Cd Length: 89 Bit Score: 126.31 E-value: 1.78e-34
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Name | Accession | Description | Interval | E-value | ||||
Med25_VWA | pfam11265 | Mediator complex subunit 25 von Willebrand factor type A; The overall function of the ... |
73-287 | 5.55e-119 | ||||
Mediator complex subunit 25 von Willebrand factor type A; The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain which is this one, an SD2 domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This VWA or von Willebrand factor type A domain when bound to RAR and the histone acetyltransferase CBP is responsible for recruiting Med1 to the rest of the Mediator complex. Pssm-ID: 463253 Cd Length: 213 Bit Score: 357.76 E-value: 5.55e-119
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Med25 | pfam11232 | Mediator complex subunit 25 PTOV activation and synapsin 2; Mediator is a large complex of up ... |
457-606 | 2.32e-79 | ||||
Mediator complex subunit 25 PTOV activation and synapsin 2; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species. It is arranged into four different sections, a core, a head, a tail and a kinase-active part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This family is the combined PTOV and SD2 domains. the PTOV domain being the domain through which Med25 co-operates with the histone acetyltransferase CBP, but the function of the SD2 domain is unclear. Pssm-ID: 463243 Cd Length: 154 Bit Score: 251.88 E-value: 2.32e-79
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Med25_SD1 | pfam11235 | Mediator complex subunit 25 synapsin 1; The overall function of the full-length Med25 is ... |
289-444 | 9.23e-43 | ||||
Mediator complex subunit 25 synapsin 1; The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA, domain, this SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This The function of the SD domains is unclear. Pssm-ID: 463244 [Multi-domain] Cd Length: 157 Bit Score: 152.63 E-value: 9.23e-43
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Med25_NR-box | pfam11244 | Mediator complex subunit 25 C-terminal NR box-containing; The overall function of the ... |
718-806 | 1.78e-34 | ||||
Mediator complex subunit 25 C-terminal NR box-containing; The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA, domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and this C-terminal NR box-containing domain (646-650) from C69-747. The NR box of MED25 is critical for its recruitment to the promoter, probably through an interaction with pre bound RAR. Pssm-ID: 463246 [Multi-domain] Cd Length: 89 Bit Score: 126.31 E-value: 1.78e-34
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PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
258-449 | 5.32e-03 | ||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 40.69 E-value: 5.32e-03
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Name | Accession | Description | Interval | E-value | ||||
Med25_VWA | pfam11265 | Mediator complex subunit 25 von Willebrand factor type A; The overall function of the ... |
73-287 | 5.55e-119 | ||||
Mediator complex subunit 25 von Willebrand factor type A; The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain which is this one, an SD2 domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This VWA or von Willebrand factor type A domain when bound to RAR and the histone acetyltransferase CBP is responsible for recruiting Med1 to the rest of the Mediator complex. Pssm-ID: 463253 Cd Length: 213 Bit Score: 357.76 E-value: 5.55e-119
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Med25 | pfam11232 | Mediator complex subunit 25 PTOV activation and synapsin 2; Mediator is a large complex of up ... |
457-606 | 2.32e-79 | ||||
Mediator complex subunit 25 PTOV activation and synapsin 2; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species. It is arranged into four different sections, a core, a head, a tail and a kinase-active part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This family is the combined PTOV and SD2 domains. the PTOV domain being the domain through which Med25 co-operates with the histone acetyltransferase CBP, but the function of the SD2 domain is unclear. Pssm-ID: 463243 Cd Length: 154 Bit Score: 251.88 E-value: 2.32e-79
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Med25_SD1 | pfam11235 | Mediator complex subunit 25 synapsin 1; The overall function of the full-length Med25 is ... |
289-444 | 9.23e-43 | ||||
Mediator complex subunit 25 synapsin 1; The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA, domain, this SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This The function of the SD domains is unclear. Pssm-ID: 463244 [Multi-domain] Cd Length: 157 Bit Score: 152.63 E-value: 9.23e-43
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Med25_NR-box | pfam11244 | Mediator complex subunit 25 C-terminal NR box-containing; The overall function of the ... |
718-806 | 1.78e-34 | ||||
Mediator complex subunit 25 C-terminal NR box-containing; The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA, domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and this C-terminal NR box-containing domain (646-650) from C69-747. The NR box of MED25 is critical for its recruitment to the promoter, probably through an interaction with pre bound RAR. Pssm-ID: 463246 [Multi-domain] Cd Length: 89 Bit Score: 126.31 E-value: 1.78e-34
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PAT1 | pfam09770 | Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
647-795 | 3.16e-05 | ||||
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division. Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 47.72 E-value: 3.16e-05
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VWA | pfam00092 | von Willebrand factor type A domain; |
78-196 | 5.63e-04 | ||||
von Willebrand factor type A domain; Pssm-ID: 459670 [Multi-domain] Cd Length: 174 Bit Score: 41.49 E-value: 5.63e-04
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PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
258-449 | 5.32e-03 | ||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 40.69 E-value: 5.32e-03
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Blast search parameters | ||||
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