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Conserved domains on  [gi|564335246|ref|XP_006231990|]
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interleukin-6 receptor subunit beta isoform X1 [Rattus norvegicus]

Protein Classification

Lep_receptor_Ig and FN3 domain-containing protein( domain architecture ID 11162515)

protein containing domains Lep_receptor_Ig, and FN3

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 42-128 3.76e-34

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


:

Pssm-ID: 461878  Cd Length: 87  Bit Score: 125.43  E-value: 3.76e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246   42 EPCGYIYPEFPVVQRGSNFTATCVLKEKCLQVYSVNATYIVWKTNHVAVPKEQVTVINRTASSVTFTDVVFQNVQLTCNI 121
Cdd:pfam06328   1 EPCGHISPSPPVVRLGSNVTASCILKENCCSHLGVEAQIIVWKLGLELIPGSQYTVLNDTVSSVTLPNLNSTRALLTCCL 80


                  ....*..
gi 564335246  122 LSFGQIE 128
Cdd:pfam06328  81 LWGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 237-336 9.27e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.83  E-value: 9.27e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246 237 PSPPHNLSVTNSEElSSILkLAWVNSGLDSILRLKSDIQYRTKDASTWIQVplEDTVSPRTSFTVQDLKPFTEYVFRIRS 316
Cdd:cd00063    1 PSPPTNLRVTDVTS-TSVT-LSWTPPEDDGGPITGYVVEYREKGSGDWKEV--EVTPGSETSYTLTGLKPGTEYEFRVRA 76

                         90       100
                 ....*....|....*....|
gi 564335246 317 IKENGkgyWSDWSEEASGTT 336
Cdd:cd00063   77 VNGGG---ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 534-614 1.15e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.78  E-value: 1.15e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246   534 PSKGPTVRTKKVGKNEAVLEWDHLPVDVQNGFIRNYSISYRTSVGKEMVVRVDSSHTEYTLSSLSSDTLYMVHMAAYTEE 613
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   .
gi 564335246   614 G 614
Cdd:smart00060  81 G 81
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
213-450 1.76e-08

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.09  E-value: 1.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246 213 VEAENALGNVS--SEPINFDPvDKVKPSPPHNLSVTNSeeLSSILKLAWVNSgldSILRLKSDIQYRTKDAS-TWIQVpl 289
Cdd:COG3401  302 VTAVDAAGNESapSNVVSVTT-DLTPPAAPSGLTATAV--GSSSITLSWTAS---SDADVTGYNVYRSTSGGgTYTKI-- 373

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246 290 eDTVSPRTSFTVQDLKPFTEYVFRIRSIkeNGKGYWSDWSEEASGTTYEDRPSKAPSFWYKVNANHPQEYRSARLIWktl 369
Cdd:COG3401  374 -AETVTTTSYTDTGLTPGTTYYYKVTAV--DAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASA--- 447

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246 370 plSEANGKILDYEVVLTQSKSVSQTYTVNGTELIVNLTNNRYVASLAARNVVGKSPATVLTIPGSHFKASHPVVDLKAFP 449
Cdd:COG3401  448 --ASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPD 525


                 .
gi 564335246 450 K 450
Cdd:COG3401  526 G 526
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 141-230 3.75e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam09067:

Pssm-ID: 473895  Cd Length: 104  Bit Score: 43.56  E-value: 3.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246  141 PPDIPTNLSCIVNEGKNMLCQWDPGRETYLETNYTLKSEWATEKFPDCRTKHGTSS-------CMMGYTPIY-FVNIEVW 212
Cdd:pfam09067   7 LPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENETVKECPLYSTSGAnstrlfiCFFPKNDVSlFVPLHIT 86

                          90
                  ....*....|....*...
gi 564335246  213 VEAENALGNVSSEPINFD 230
Cdd:pfam09067  87 VVATNTNGTRYSRELSVE 104
 
Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 42-128 3.76e-34

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 125.43  E-value: 3.76e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246   42 EPCGYIYPEFPVVQRGSNFTATCVLKEKCLQVYSVNATYIVWKTNHVAVPKEQVTVINRTASSVTFTDVVFQNVQLTCNI 121
Cdd:pfam06328   1 EPCGHISPSPPVVRLGSNVTASCILKENCCSHLGVEAQIIVWKLGLELIPGSQYTVLNDTVSSVTLPNLNSTRALLTCCL 80


                  ....*..
gi 564335246  122 LSFGQIE 128
Cdd:pfam06328  81 LWGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 237-336 9.27e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.83  E-value: 9.27e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246 237 PSPPHNLSVTNSEElSSILkLAWVNSGLDSILRLKSDIQYRTKDASTWIQVplEDTVSPRTSFTVQDLKPFTEYVFRIRS 316
Cdd:cd00063    1 PSPPTNLRVTDVTS-TSVT-LSWTPPEDDGGPITGYVVEYREKGSGDWKEV--EVTPGSETSYTLTGLKPGTEYEFRVRA 76

                         90       100
                 ....*....|....*....|
gi 564335246 317 IKENGkgyWSDWSEEASGTT 336
Cdd:cd00063   77 VNGGG---ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 534-614 1.15e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.78  E-value: 1.15e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246   534 PSKGPTVRTKKVGKNEAVLEWDHLPVDVQNGFIRNYSISYRTSVGKEMVVRVDSSHTEYTLSSLSSDTLYMVHMAAYTEE 613
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   .
gi 564335246   614 G 614
Cdd:smart00060  81 G 81
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 534-625 1.75e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.88  E-value: 1.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246 534 PSKGPTVRTKKVGKNEAVLEWDhlPVDVQNGFIRNYSISYRTSVGKEM--VVRVDSSHTEYTLSSLSSDTLYMVHMAAYT 611
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWT--PPEDDGGPITGYVVEYREKGSGDWkeVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                         90
                 ....*....|....*
gi 564335246 612 EEG-GKDGPEFTFTT 625
Cdd:cd00063   79 GGGeSPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
213-450 1.76e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.09  E-value: 1.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246 213 VEAENALGNVS--SEPINFDPvDKVKPSPPHNLSVTNSeeLSSILKLAWVNSgldSILRLKSDIQYRTKDAS-TWIQVpl 289
Cdd:COG3401  302 VTAVDAAGNESapSNVVSVTT-DLTPPAAPSGLTATAV--GSSSITLSWTAS---SDADVTGYNVYRSTSGGgTYTKI-- 373

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246 290 eDTVSPRTSFTVQDLKPFTEYVFRIRSIkeNGKGYWSDWSEEASGTTYEDRPSKAPSFWYKVNANHPQEYRSARLIWktl 369
Cdd:COG3401  374 -AETVTTTSYTDTGLTPGTTYYYKVTAV--DAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASA--- 447

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246 370 plSEANGKILDYEVVLTQSKSVSQTYTVNGTELIVNLTNNRYVASLAARNVVGKSPATVLTIPGSHFKASHPVVDLKAFP 449
Cdd:COG3401  448 --ASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPD 525


                 .
gi 564335246 450 K 450
Cdd:COG3401  526 G 526
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 237-323 3.02e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.85  E-value: 3.02e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246   237 PSPPHNLSVTNSEelSSILKLAWVNSGLDSILRLKsdIQYRTKDASTWIQVPLEDTVSPRTSFTVQDLKPFTEYVFRIRS 316
Cdd:smart00060   1 PSPPSNLRVTDVT--STSVTLSWEPPPDDGITGYI--VGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76


                   ....*..
gi 564335246   317 IKENGKG 323
Cdd:smart00060  77 VNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
238-326 7.60e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 50.49  E-value: 7.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246  238 SPPHNLSVTNSEElSSILkLAW--VNSGLDSILRLKsdIQYRTKDAStwiQVPLEDTVSP-RTSFTVQDLKPFTEYVFRI 314
Cdd:pfam00041   1 SAPSNLTVTDVTS-TSLT-VSWtpPPDGNGPITGYE--VEYRPKNSG---EPWNEITVPGtTTSVTLTGLKPGTEYEVRV 73

                          90
                  ....*....|..
gi 564335246  315 RSIKENGKGYWS 326
Cdd:pfam00041  74 QAVNGGGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
237-346 7.52e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 49.62  E-value: 7.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246 237 PSPPHNLSVTNseELSSILKLAWVNSGLDSILRLKsdIQYRTKDASTWIQVpledTVSPRTSFTVQDLKPFTEYVFRIRS 316
Cdd:COG3401  233 PSAPTGLTATA--DTPGSVTLSWDPVTESDATGYR--VYRSNSGDGPFTKV----ATVTTTSYTDTGLTNGTTYYYRVTA 304

                         90       100       110
                 ....*....|....*....|....*....|
gi 564335246 317 IkeNGKGYWSDWSEEASGTTYEDRPSkAPS 346
Cdd:COG3401  305 V--DAAGNESAPSNVVSVTTDLTPPA-APS 331
fn3 pfam00041
Fibronectin type III domain;
545-614 1.73e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.94  E-value: 1.73e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564335246  545 VGKNEAVLEWDhlPVDVQNGFIRNYSISYRTSVGKEMV--VRVDSSHTEYTLSSLSSDTLYMVHMAAYTEEG 614
Cdd:pfam00041  11 VTSTSLTVSWT--PPPDGNGPITGYEVEYRPKNSGEPWneITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 141-230 3.75e-05

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 43.56  E-value: 3.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246  141 PPDIPTNLSCIVNEGKNMLCQWDPGRETYLETNYTLKSEWATEKFPDCRTKHGTSS-------CMMGYTPIY-FVNIEVW 212
Cdd:pfam09067   7 LPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENETVKECPLYSTSGAnstrlfiCFFPKNDVSlFVPLHIT 86

                          90
                  ....*....|....*...
gi 564335246  213 VEAENALGNVSSEPINFD 230
Cdd:pfam09067  87 VVATNTNGTRYSRELSVE 104
 
Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 42-128 3.76e-34

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 125.43  E-value: 3.76e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246   42 EPCGYIYPEFPVVQRGSNFTATCVLKEKCLQVYSVNATYIVWKTNHVAVPKEQVTVINRTASSVTFTDVVFQNVQLTCNI 121
Cdd:pfam06328   1 EPCGHISPSPPVVRLGSNVTASCILKENCCSHLGVEAQIIVWKLGLELIPGSQYTVLNDTVSSVTLPNLNSTRALLTCCL 80


                  ....*..
gi 564335246  122 LSFGQIE 128
Cdd:pfam06328  81 LWGGQLQ 87
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 237-336 9.27e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.83  E-value: 9.27e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246 237 PSPPHNLSVTNSEElSSILkLAWVNSGLDSILRLKSDIQYRTKDASTWIQVplEDTVSPRTSFTVQDLKPFTEYVFRIRS 316
Cdd:cd00063    1 PSPPTNLRVTDVTS-TSVT-LSWTPPEDDGGPITGYVVEYREKGSGDWKEV--EVTPGSETSYTLTGLKPGTEYEFRVRA 76

                         90       100
                 ....*....|....*....|
gi 564335246 317 IKENGkgyWSDWSEEASGTT 336
Cdd:cd00063   77 VNGGG---ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 534-614 1.15e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 58.78  E-value: 1.15e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246   534 PSKGPTVRTKKVGKNEAVLEWDHLPVDVQNGFIRNYSISYRTSVGKEMVVRVDSSHTEYTLSSLSSDTLYMVHMAAYTEE 613
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   .
gi 564335246   614 G 614
Cdd:smart00060  81 G 81
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 534-625 1.75e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.88  E-value: 1.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246 534 PSKGPTVRTKKVGKNEAVLEWDhlPVDVQNGFIRNYSISYRTSVGKEM--VVRVDSSHTEYTLSSLSSDTLYMVHMAAYT 611
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWT--PPEDDGGPITGYVVEYREKGSGDWkeVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                         90
                 ....*....|....*
gi 564335246 612 EEG-GKDGPEFTFTT 625
Cdd:cd00063   79 GGGeSPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
213-450 1.76e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.09  E-value: 1.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246 213 VEAENALGNVS--SEPINFDPvDKVKPSPPHNLSVTNSeeLSSILKLAWVNSgldSILRLKSDIQYRTKDAS-TWIQVpl 289
Cdd:COG3401  302 VTAVDAAGNESapSNVVSVTT-DLTPPAAPSGLTATAV--GSSSITLSWTAS---SDADVTGYNVYRSTSGGgTYTKI-- 373

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246 290 eDTVSPRTSFTVQDLKPFTEYVFRIRSIkeNGKGYWSDWSEEASGTTYEDRPSKAPSFWYKVNANHPQEYRSARLIWktl 369
Cdd:COG3401  374 -AETVTTTSYTDTGLTPGTTYYYKVTAV--DAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASA--- 447

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246 370 plSEANGKILDYEVVLTQSKSVSQTYTVNGTELIVNLTNNRYVASLAARNVVGKSPATVLTIPGSHFKASHPVVDLKAFP 449
Cdd:COG3401  448 --ASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPD 525


                 .
gi 564335246 450 K 450
Cdd:COG3401  526 G 526
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 237-323 3.02e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.85  E-value: 3.02e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246   237 PSPPHNLSVTNSEelSSILKLAWVNSGLDSILRLKsdIQYRTKDASTWIQVPLEDTVSPRTSFTVQDLKPFTEYVFRIRS 316
Cdd:smart00060   1 PSPPSNLRVTDVT--STSVTLSWEPPPDDGITGYI--VGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76


                   ....*..
gi 564335246   317 IKENGKG 323
Cdd:smart00060  77 VNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
238-326 7.60e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 50.49  E-value: 7.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246  238 SPPHNLSVTNSEElSSILkLAW--VNSGLDSILRLKsdIQYRTKDAStwiQVPLEDTVSP-RTSFTVQDLKPFTEYVFRI 314
Cdd:pfam00041   1 SAPSNLTVTDVTS-TSLT-VSWtpPPDGNGPITGYE--VEYRPKNSG---EPWNEITVPGtTTSVTLTGLKPGTEYEVRV 73

                          90
                  ....*....|..
gi 564335246  315 RSIKENGKGYWS 326
Cdd:pfam00041  74 QAVNGGGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
237-346 7.52e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 49.62  E-value: 7.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246 237 PSPPHNLSVTNseELSSILKLAWVNSGLDSILRLKsdIQYRTKDASTWIQVpledTVSPRTSFTVQDLKPFTEYVFRIRS 316
Cdd:COG3401  233 PSAPTGLTATA--DTPGSVTLSWDPVTESDATGYR--VYRSNSGDGPFTKV----ATVTTTSYTDTGLTNGTTYYYRVTA 304

                         90       100       110
                 ....*....|....*....|....*....|
gi 564335246 317 IkeNGKGYWSDWSEEASGTTYEDRPSkAPS 346
Cdd:COG3401  305 V--DAAGNESAPSNVVSVTTDLTPPA-APS 331
fn3 pfam00041
Fibronectin type III domain;
545-614 1.73e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.94  E-value: 1.73e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564335246  545 VGKNEAVLEWDhlPVDVQNGFIRNYSISYRTSVGKEMV--VRVDSSHTEYTLSSLSSDTLYMVHMAAYTEEG 614
Cdd:pfam00041  11 VTSTSLTVSWT--PPPDGNGPITGYEVEYRPKNSGEPWneITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 141-230 3.75e-05

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 43.56  E-value: 3.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246  141 PPDIPTNLSCIVNEGKNMLCQWDPGRETYLETNYTLKSEWATEKFPDCRTKHGTSS-------CMMGYTPIY-FVNIEVW 212
Cdd:pfam09067   7 LPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENETVKECPLYSTSGAnstrlfiCFFPKNDVSlFVPLHIT 86

                          90
                  ....*....|....*...
gi 564335246  213 VEAENALGNVSSEPINFD 230
Cdd:pfam09067  87 VVATNTNGTRYSRELSVE 104
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
141-339 1.05e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 43.01  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246 141 PPDIPTNLSCIVNEGKN----MLCQWDPGRETyleTNYTLK-----SEWatekfpdcRTKHGTSSCMMGYTPIYFVNIEV 211
Cdd:COG4733  533 PVNVTTSESLSVVAQGTavttLTVSWDAPAGA---VAYEVEwrrddGNW--------VSVPRTSGTSFEVPGIYAGDYEV 601

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246 212 WVEAENALGnVSSEPINFDPV----DKVKPSPPHNLSVTNSEELssiLKLAWVNS-GLDSilrLKSDIQYRTkdASTWIQ 286
Cdd:COG4733  602 RVRAINALG-VSSAWAASSETtvtgKTAPPPAPTGLTATGGLGG---ITLSWSFPvDADT---LRTEIRYST--TGDWAS 672

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 564335246 287 VPLEDTVSPRTSFTVQDLKPFTEYVFRIRSIKENGKGywSDWseEASGTTYED 339
Cdd:COG4733  673 ATVAQALYPGNTYTLAGLKAGQTYYYRARAVDRSGNV--SAW--WVSGQASAD 721
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 147-231 2.89e-03

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 37.77  E-value: 2.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564335246  147 NLSCIVNEGKNMLCQWDPGRETYLETNYTLKSEWAT-EKFPDCRTKHGTS----SCMMGYTPI-----YFVNIEVWVeaE 216
Cdd:pfam09240   1 DLTCFIHNPSNLSCEWKPGPNAPPDTNYVLYVRKSPlGPVLQCQYYIRDDgtriGCQFDDLEGlsssfHQVYICVNG--S 78

                          90
                  ....*....|....*
gi 564335246  217 NALGNVSSEPINFDP 231
Cdd:pfam09240  79 SSAGPIRSSDQTFQL 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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