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Conserved domains on  [gi|564348150|ref|XP_006237066|]
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cullin-associated NEDD8-dissociated protein 2 isoform X1 [Rattus norvegicus]

Protein Classification

HEAT_EZ and TIP120 domain-containing protein( domain architecture ID 10607804)

HEAT_EZ and TIP120 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIP120 pfam08623
TATA-binding protein interacting (TIP20); TIP120 (also known as cullin-associated and ...
 1095-1225 7.55e-72

TATA-binding protein interacting (TIP20); TIP120 (also known as cullin-associated and neddylation-dissociated protein 1) is a TATA binding protein interacting protein that enhances transcription.


:

Pssm-ID: 430111  Cd Length: 165  Bit Score: 236.65  E-value: 7.55e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348150  1095 YQETKIRRDLIREVEMGPFKHTVDDGLDVRKAAFECMYSLLESCLGQLDICEFLNHVEDGLKDHYDIRMLTFIMLARLAA 1174
Cdd:pfam08623   14 YAETKVKPELIREVQMGPFKHKVDDGLELRKAAYECLYTLLDTCLDRLDISEFLDRVIAGLSDEHDIKMLCNLMLIKLVV 93

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 564348150  1175 LCPAPVLQRVDRLIEPLRATCTAKVKAGSVKQELEKQDELKRSAMRAVAAL 1225
Cdd:pfam08623   94 LAPDEVLRRLDSLVEPLRKTLSKKLKENAVKQELEKQEELIRSVLRASAAL 144
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 188-240 7.02e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


:

Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.89  E-value: 7.02e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 564348150   188 VQLEALDILSDMLSRLGAPLGTFHASLLHCLLPQLSSPRLAVRKRTVVALGHL 240
Cdd:pfam13513    3 VREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 878-925 5.45e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


:

Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 36.19  E-value: 5.45e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 564348150   878 VLAFLSLAEVGQVAGPGPQRELKTVLLEALGSPSEDVRAAAAYALGRV 925
Cdd:pfam13513    8 ALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
 
Name Accession Description Interval E-value
TIP120 pfam08623
TATA-binding protein interacting (TIP20); TIP120 (also known as cullin-associated and ...
 1095-1225 7.55e-72

TATA-binding protein interacting (TIP20); TIP120 (also known as cullin-associated and neddylation-dissociated protein 1) is a TATA binding protein interacting protein that enhances transcription.


Pssm-ID: 430111  Cd Length: 165  Bit Score: 236.65  E-value: 7.55e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348150  1095 YQETKIRRDLIREVEMGPFKHTVDDGLDVRKAAFECMYSLLESCLGQLDICEFLNHVEDGLKDHYDIRMLTFIMLARLAA 1174
Cdd:pfam08623   14 YAETKVKPELIREVQMGPFKHKVDDGLELRKAAYECLYTLLDTCLDRLDISEFLDRVIAGLSDEHDIKMLCNLMLIKLVV 93

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 564348150  1175 LCPAPVLQRVDRLIEPLRATCTAKVKAGSVKQELEKQDELKRSAMRAVAAL 1225
Cdd:pfam08623   94 LAPDEVLRRLDSLVEPLRKTLSKKLKENAVKQELEKQEELIRSVLRASAAL 144
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 188-240 7.02e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.89  E-value: 7.02e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 564348150   188 VQLEALDILSDMLSRLGAPLGTFHASLLHCLLPQLSSPRLAVRKRTVVALGHL 240
Cdd:pfam13513    3 VREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 878-925 5.45e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 36.19  E-value: 5.45e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 564348150   878 VLAFLSLAEVGQVAGPGPQRELKTVLLEALGSPSEDVRAAAAYALGRV 925
Cdd:pfam13513    8 ALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
 
Name Accession Description Interval E-value
TIP120 pfam08623
TATA-binding protein interacting (TIP20); TIP120 (also known as cullin-associated and ...
 1095-1225 7.55e-72

TATA-binding protein interacting (TIP20); TIP120 (also known as cullin-associated and neddylation-dissociated protein 1) is a TATA binding protein interacting protein that enhances transcription.


Pssm-ID: 430111  Cd Length: 165  Bit Score: 236.65  E-value: 7.55e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348150  1095 YQETKIRRDLIREVEMGPFKHTVDDGLDVRKAAFECMYSLLESCLGQLDICEFLNHVEDGLKDHYDIRMLTFIMLARLAA 1174
Cdd:pfam08623   14 YAETKVKPELIREVQMGPFKHKVDDGLELRKAAYECLYTLLDTCLDRLDISEFLDRVIAGLSDEHDIKMLCNLMLIKLVV 93

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 564348150  1175 LCPAPVLQRVDRLIEPLRATCTAKVKAGSVKQELEKQDELKRSAMRAVAAL 1225
Cdd:pfam08623   94 LAPDEVLRRLDSLVEPLRKTLSKKLKENAVKQELEKQEELIRSVLRASAAL 144
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 188-240 7.02e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.89  E-value: 7.02e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 564348150   188 VQLEALDILSDMLSRLGAPLGTFHASLLHCLLPQLSSPRLAVRKRTVVALGHL 240
Cdd:pfam13513    3 VREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 878-925 5.45e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 36.19  E-value: 5.45e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 564348150   878 VLAFLSLAEVGQVAGPGPQRELKTVLLEALGSPSEDVRAAAAYALGRV 925
Cdd:pfam13513    8 ALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 871-956 9.84e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 36.55  E-value: 9.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564348150   871 HSSTGVKVLAFLSLAEVGQvagpgpqRELKTVLLEALGSPSEDVRAAAAYALGRVGAgnlPDFLPFL--LAQIEAQPRRQ 948
Cdd:pfam13646   11 DPDPEVRAAAIRALGRIGD-------PEAVPALLELLKDEDPAVRRAAAEALGKIGD---PEALPALleLLRDDDDDVVR 80


                   ....*...
gi 564348150   949 YLLLHALR 956
Cdd:pfam13646   81 AAAAEALA 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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